Digital Commons Network^™

Market Entry Strategy For Black Garlic Supplements In Myanmar Through Partnership With Cmhl, Saw Yoon Yu Nan

Chulalongkorn University Theses and Dissertations (Chula ETD)

The COVID-19 pandemic has significantly increased the demand for supplements, vitamins, and minerals as people seek to boost their immune systems and overall wellness. Among these, black garlic has gained popularity for its unique flavor and perceived health benefits. This research explores the feasibility of entering the Myanmar market with black garlic supplements through a strategic partnership with City Mart Holdings Limited (CMHL), Myanmar's largest retail conglomerate.The study aims to assess market demand, regulatory requirements, and CMHL's distribution network to develop an effective market entry strategy. Key objectives include evaluating consumer interest, understanding regulatory hurdles, and leveraging CMHL's extensive distribution …

Exploring Market Dynamic And Strategies For Food Supplement Industry In Thailand: A Case Study Of Black Garlic, Nan Su Wai

Chulalongkorn University Theses and Dissertations (Chula ETD)

The food supplement industry in Thailand has been experiencing rapid growth due to increasing health consciousness, an aging population, rising disposable incomes, and urbanization. Within this industry, black garlic has become one of the significant products in Thailand due to its enhanced nutrient profile compared to fresh garlic. The paper aims to provide a comprehensive understanding of the current market landscape, consumer preferences and trends, and to recommend strategic approaches for the development of the black garlic sector. This paper focuses on analyzing the macro and micro-environmental factors affecting the food supplement industry, specifying the black garlic market in Thailand. …

Mediation By Fatalism Of The Association Between Symptom Burden And Self-Care Management In Patients With Heart Failure, Ashmita Thapa, Misook L. Chung, Jia-Rong Wu, Abigail Latimer, Terry A. Lennie, Gia Mudd-Martin, Chin-Yen Lin, Jessica Harman Thompson, Junghee Kang, Debra K. Moser

UK CARES Faculty Publications

Background: Clinicians and researchers often assume that symptom burden is associated with self-care management (SCM) in patients with heart failure (HF). However, that association is often not borne out in simple regression analyses and may be because another variable mediates the association. Fatalism is an appropriate candidate for mediation and is the belief that circumstances are predetermined without opportunity for control by individuals.

Objective: Our objective was to determine whether fatalism mediated the relationship of symptom burden with SCM among adults with HF.

Methods: We conducted a secondary analysis (N = 95) from a clinical trial. We used Self-care of …

Impact Of A Culturally-Grounded And Interprofessional Approach To Managing Latino/Hispanic Patients At Risk For Or Diagnosed With Type 2 Diabetes Mellitus: A Pilot Study, Jahnavi Yalamanchili

University of the Pacific Theses and Dissertations

Background: Despite significant progress in diabetes research, there remain significant health disparities between Hispanic/Latino patients in the United States, particularly those with lower socioeconomic status, compared to non-Hispanic white patients. Previous studies have identified potential reasons behind these disparities, including the need for a multifaceted approach that addresses social determinants of health (SDOH) faced by patients. Social cognitive theory (SCT) stipulates that interventions that promote self-management by improving knowledge, self-efficacy, and problem-solving skills can be successful in improving health outcomes. However, there is a paucity of studies that have evaluated an interprofessional approach to providing culturally relevant care, in particular …

Medical Expenditures And The Measurement Of Poverty In The United States, Luke Petach, David K. Wyant

Funded Scholarship

Using data from the Medical Expenditure Panel Survey (MEPS) we estimate the fraction of the US population that is health poor. A person is health poor if their income prior to paying health insurance premiums and out-of-pocket healthcare costs is above the poverty line, but their income net-of-premiums and out-of-pocket healthcare costs is below the poverty line. Because resources used to finance health insurance premiums and out-of-pocket costs are (A) lexicographically preferred and (B) cannot be used to maintain an individual’s standard of living, they should be excluded from official poverty estimates. Approximately 1% to 2% of the US population …

Wvoice: A Health Science Podcast, Giorgi Morrone

Graduate Student Scholarship

Marginalized groups experience health disparities and stigma from healthcare providers, which negatively impact their quality of life. Occupational injustices occur in marginalized communities due to a lack of accessible and inclusive environments and limited services and support for diverse needs. A creative way to implement interdisciplinary teamwork in healthcare may be podcasting. This study aimed to assess the feasibility of a podcast as a teaching tool for health science students and to increase knowledge related to the social determinants of health and stigma that impacted marginalized groups in West Virginia. A mixed methods approach was utilized to assess the feasibility, …

Exploration Of Educator Training Requirements And Curriculum Standards And How These Could Impact The Development Of Children Aged 3 – 4 Years In Daycare Centers: A Qualitative Study, Katie Conley, Melissa Learish, Ayric Fetty

Graduate Student Scholarship

Daycare teachers, in general, are responsible for the support and education of children as they develop skills and achieve milestones. This study aimed to investigate what training and education related to developmental delays are provided to daycare teachers, the actions taken by teachers or directors to identify developmental delays, and how daycare curricula are developed and personalized for individual needs. Researchers conducted semi-structured interviews with daycare teachers who taught three and four-year-olds as well as site directors at three different facilities in Morgantown, West Virginia. Responses were transcribed and coded into six themes. Results indicate teachers have limited training and …

Planning And Pedagogical Considerations For Teaching Children With Autism Spectrum Disorder In Physical Education, Andrew Sortwell

Medical Papers and Journal Articles

Around the world, autism spectrum disorder (ASD) is a prevalent neurodevelopmental condition. It is linked to a wide range of deficiencies across multiple domains, including restrictive and repetitive behaviors that impair interaction or engagement with others. School-aged children with ASD face challenges that make physical activity more difficult. To address challenges associated with ASD, physical education interventions need to be tailored to the child’s needs and abilities. Despite advances in research on children with ASD in physical education, adopting contemporary approaches is yet to be the norm. This review aimed to examine the literature on intervention models to improve the …

A Worldwide Overview Of The Status And Prospects Of Edible Insect Production, R. Caparros Megido, F. Francis, E. Haubruge, P. Le Gall, J. K. Tomberlin, C. D. Miranda, H. R. Jordan, C. J. Picard, M. J.M. Pino, J. Ramos-Elordy, E. Katz, K. B. Barragán-Fonseca, E. M. Costa-Neto, R. Ponce-Reyes, G. Wijffels, S. Ghosh, C. Jung, Y. S. Han, B. Conti, A. Vilcinskas, C. M. Tanga, M. O. Kababu, D. Beesigamukama, J. A. Morales Ramos, A. Van Huis

All Peer-Reviewed Publications

There has been continuous and growing interest in edible insects. Worldwide, various levels of insect farming are emerging, ranging from small domestic farms to vertical farms reaching heights of 36 meters, accommodating several million growing insects. The appeal of insects lies in their ecological benefits, as they contribute to the valorization of unde-rutilized organic residues while requiring minimal space and water. The selection of insect species is influenced not only by their biology and behavior but also by local preferences and customs, varying with the scale of production and geographi-cal location. This review article aims to provide an updated overview …

First-In-Human Phase 1 Study Of The Arginase Inhibitor Incb001158 Alone Or Combined With Pembrolizumab In Patients With Advanced Or Metastatic Solid Tumours, Aung Naing, Kyriakos P Papadopoulos, Michael J Pishvaian, Osama Rahma, Glenn J Hanna, Elena Garralda, Omar Saavedra, Sven Gogov, Howard Kallender, Lulu Cheng, Michael Smith, Xuejun Chen, Emil Kuriakose, Todd Bauer

Faculty, Staff and Student Publications

Objective: The arginase inhibitor INCB001158 was evaluated for safety (primary endpoint) in locally advanced or metastatic solid tumours; pharmacokinetics, pharmacodynamics and efficacy were also assessed.

Methods and analysis: In this non-randomised, open-label, three-part phase 1 study, INCB001158 was orally administered two times per day as monotherapy or in combination with intravenous pembrolizumab 200 mg every 3 weeks. Dose expansion was conducted in tumour-type cohorts (with or without prior anti-PD-1/PD-L1 (programmed death protein 1/programmed death ligand 1) therapy).

Results: A total of 107 patients received INCB001158 50-150 mg two times per day as monotherapy, and 153 patients, including 6 with moderate …

Awareness And Interest In Cannabis Use For Cancer Management Among Cancer Survivors, Ikponmwosa Osaghae, Rajesh Talluri, Onyema Greg Chido-Amajuoyi, Kimberson Tanco, Dimpy P Shah, Mala Pande, Sanjay Shete

Faculty, Staff and Student Publications

BACKGROUND: We examined the awareness, interest, and information sources relating to cannabis use for cancer management (including management of cancer symptoms and treatment-related side effects) and determined factors associated with cancer survivors' awareness and interest in learning about cannabis use for cancer management.

METHODS: This was a cross-sectional study of adult cancer survivors (N = 1886) receiving treatment at a comprehensive cancer center. Weighted prevalence and multivariable logistic regression analyses were conducted.

RESULTS: Among cancer survivors, 88% were aware and 60% were interested in learning about cannabis use for cancer management. Common sources of information to learn about cannabis use …

Scoping Review: The Effects Of Interrupted Onabotulinumtoxin A Treatment For Chronic Migraine Prevention During The Covid-19 Pandemic, Qing Zhao Ruan, Daniel J Pak, Amitabh Gulati, Moises Dominguez, Sudhir Diwan, Jamal Hasoon, Timothy R Deer, R Jason Yong, Abdulrazaq Albilali, Amanda Macone, Sait Ashina, Christopher L Robinson

Faculty, Staff and Student Publications

Objective: To systematically examine the literature on the clinical consequences of inadvertent delays in scheduled onabotulinumtoxin A (OTA) therapy for chronic migraine during the COVID-19 pandemic and assess recommendations when access to OTA is limited.

Background: The coronavirus (COVID-19) pandemic was unprecedented in its impact on the global medical community. Most healthcare institutions in the United States (US) and the world had begun significantly limiting elective procedures, undermining management of many debilitating chronic conditions. OTA injections, were similarly involuntarily postponed, leading to significant setbacks in symptom control.

Methods: A comprehensive literature search was conducted on databases of Medline and Embase …

Benign Disorders Of The Mediastinum: A Narrative Review, Saad Farooq, Sabiha Armin, Daniel Ocazionez, Rosa M Estrada-Y-Martin, Sujith V Cherian

Faculty, Staff and Student Publications

Background and objective: There are several benign processes that affect the mediastinum with considerable morbidity that may range from reactive entities to neoplastic disorders. This review article will focus on non-neoplastic benign mediastinal diseases which include large vessel vasculitis such as Takayasu and giant cell arteritis, mediastinal granulomas, fibrosing mediastinitis and mediastinal infections. These diseases can cause significant morbidity and mortality; therefore, we aim to familiarize readers with the pathophysiology, epidemiology and diagnosis of these mediastinal diseases and provide an update on the treatment options available.

Methods: We searched various databases such as PubMed and Google Scholar from August 2023 …

The Emerging Role Of Notch3 Receptor Signalling In Human Lung Diseases, Grant W Goodman, Patrick Devlin, Bryce E West, Rodney M Ritzel

Faculty, Staff and Student Publications

The recent identification of skull bone marrow as a reactive hematopoietic niche that can contribute to and direct leukocyte trafficking into the meninges and brain has transformed our view of this bone structure from a solid, protective casing to a living, dynamic tissue poised to modulate brain homeostasis and neuroinflammation. This emerging concept may be highly relevant to injuries that directly impact the skull such as in traumatic brain injury (TBI). From mild concussion to severe contusion with skull fracturing, the bone marrow response of this local myeloid cell reservoir has the potential to impact not just the acute inflammatory …

Impact Of Maternal Depressive Symptoms On Offspring Executive Functions: A Systematic Review, Júlia De Souza Rodrigues, María Pastor-Valero, Lucas R Trambaiolli, Ana Beatriz Bozzini, Alicia Matijasevich

Faculty, Staff and Student Publications

OBJECTIVE: To conduct a thorough examination of the current understanding of the effect of maternal depression exposure on the executive functions (EFs) of offspring.

METHODS: Following the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) statement, a comprehensive search for peer-reviewed cohort studies was performed on the MEDLINE (via PubMed), ScienceDirect, LILACS, PsycINFO, and SciELO databases. Study quality was assessed using the National Heart, Lung, and Blood Institute (NHLBI) Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. The evidence was evaluated using the Grading of Recommendation, Assessment, Development, and Evaluation framework.

RESULTS: Thirty-three cohort studies from different countries, …

Diet-Stimulated Marrow Adiposity Fails To Worsen Early, Age-Related Bone Loss, Cody Mcgrath, Sarah E Little-Letsinger, Gabriel M Pagnotti, Buer Sen, Zhihui Xie, Gunes Uzer, Guniz B Uzer, Xiaopeng Zong, Martin A Styner, Janet Rubin, Maya Styner

Faculty, Staff and Student Publications

Introduction: Longitudinal effect of diet-induced obesity on bone is uncertain. Prior work showed both no effect and a decrement in bone density or quality when obesity begins prior to skeletal maturity. We aimed to quantify long-term effects of obesity on bone and bone marrow adipose tissue (BMAT) in adulthood.

Methods: Skeletally mature, female C57BL/6 mice (n = 70) aged 12 weeks were randomly allocated to low-fat diet (LFD; 10% kcal fat; n = 30) or high-fat diet (HFD; 60% kcal fat; n = 30), with analyses at 12, 15, 18, and 24 weeks (n = 10/group). Tibial microarchitecture was analyzed …

Cardiovascular Risk Factors In Sheehan's Syndrome: A Case-Control Study, Mayur Agrawal, Subhash C Yadav, Swish K Singh, Sheo Kumar, Krishnarpan Chatterjee, Naveen K Garg

Faculty, Staff and Student Publications

INTRODUCTION: Obesity, dyslipidaemia and insulin resistance are associated with hypopituitarism. The association between these conditions and Sheehan's syndrome (SS) caused by post-partum pituitary gland necrosis is poorly understood. This study aimed to assess cardiovascular risk surrogate markers in SS patients, and we compared clinical, biochemical and radiological testing with healthy controls.

METHODS: In this cross-sectional study, we studied 45 patients with SS on standard replacement therapy and compared them with healthy controls. All subjects underwent anthropometric, inflammatory marker and hormonal measurement (adrenocorticotropic hormone (ACTH), stimulated cortisol, insulin-like growth factor-1 (IGF-1), thyroxine (T4), follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol (E2), …

Screening For Food And Nutrition Insecurity In The Healthcare Setting: A Cross-Sectional Survey Of Non-Medicaid Insured Adults In An Integrated Healthcare Delivery System, Carmen Byker Shanks, Nancy P Gordon

Faculty, Staff and Student Publications

OBJECTIVES: Healthcare screening identifies factors that impact patient health and well-being. Hunger as a Vital Sign (HVS) is widely applied as a screening tool to assess food security. However, there are no common practice screening questions to identify patients who are nutrition insecure or acquire free food from community-based organizations. This study used self-reported survey data from a non-Medicaid insured adult population approximately one year after the start of the COVID-19 pandemic (2021). The survey examined the extent to which the HVS measure might have under-estimated population-level food insecurity and/or nutrition insecurity, as well as under-identified food and nutrition insecurity …

From Mitochondria To Tumor Suppression: Acat1’S Crucial Role In Gastric Cancer, Wei He, Yanfang Li, Song-Bai Liu, Ying Chang, Shiyuan Han, Xingyu Han, Zixin Ma, Hesham M Amin, Yao-Hua Song, Jin Zhou

Faculty, Staff and Student Publications

Acetyl CoA acetyltransferase 1 (ACAT1), a mitochondrial enzyme, is mainly involved in the formation and decomposition of ketones, isoleucine, and fatty acids. Previous clinical studies showed that mutations in the ACAT1 gene lead to ketoacidosis, Notably the role of ACAT1 in human cancer' pathogenesis varies depending on cancer type, and its specific role in gastric cancer remains largely unknown. In the current study, we found that the expression of ACAT1 in primary late-stage gastric cancer tumor tissues was significantly lower than in early-stage tumors. This observation was further confirmed in high-grade gastric cancer cell line MKN45. The expression of CD44 …

Mental Health Prevention And Treatment Programs For Infants Experiencing Homelessness: A Systematic Review, Megan M Hare, Taylor D Landis, Melissa Hernandez, Paulo A Graziano

Faculty, Staff and Student Publications

Experiencing homelessness in infancy has been linked to negative physical and mental health outcomes. Parental well-being and the parent-infant relationship can also be negatively impacted by experiencing homelessness. While numerous parent-based infant mental health programs have been identified by a recent review, the goal of this study was to further determine the extent to which these existing programs were developed and/or examined with at-risk populations such as families experiencing homelessness. Out of 60 programs identified by Hare et al., in press, only three had been implemented specifically in shelter settings with infants 0-12 months (Parent-Infant Psychotherapy, New Beginnings, and My …

Effect Of Plant Based Nutritional Education On A1c Levels In Type 2 Diabetic Adults, Candice Kim

Master of Science in Nursing Family Nurse Practitioner

Type 2 diabetic adults are those with a condition that prevents production of enough insulin and are also resistant to the effects of insulin itself (American Diabetes Association, 2018). According to the U.S. Department of Health and Human Services, “diabetes mellitus affects an estimated 29.1 million people in the United States, and is the 7th leading cause of death,” (Office of Disease Prevention and Health Promotion, 2022, section 3). Risk factors that affect type 2 diabetic adults include being overweight, aged 45 or older, high blood pressure, and high level of triglycerides (National Institute of Diabetes and Digestive and Kidney …

The Effects Of Aerobic Exercise To Improve Depression In Overweight Adults, Curtis Lura

Master of Science in Nursing Family Nurse Practitioner

Overweight/obese adults are at an increased risk for both physical and mental comorbidities (CDC, 2019). Depression is a common comorbidity in those that are obese (CDC, 2019) and the standard of care currently to treat depression may increase the risk of physical comorbidities because weight gain is a common side effect of antidepressants (Hall-Flavin, 2018). The aim of this capstone research paper is to present evidence that an aerobic exercise regimen can be a valid treatment option for depression.

Effectiveness Of An Inclusive, Small-Group Adapted Aquatics Program On Increasing Vo2max In Children With Autism Spectrum Disorder, Peggy Manuelita Scarborough

Cal Poly Humboldt theses and projects

There is a need to examine the effectiveness of interventions, such as swimming, that are aimed at increasing physical health and developing psychomotor skills in an inclusive setting for children with ASD. The purpose of this study was to examine the effectiveness of an inclusive, small-group adapted aquatics program on increasing VO₂max in children with ASD. Participants included two 11-year-old children diagnosed with ASD. The study took place over eight weeks and included a six-week Small-Group Adapted Aquatics (SGAA) program. Participants were assessed for VO₂max using the 20m PACER test during week one and week eight …

The Nature And Extent Of Algal Symbiosis In Three North American Ranids, Zachary T. Vegso

Cal Poly Humboldt theses and projects

The symbiotic relationship between the chlamydomonad green alga Oophila amblystomatis and embryos of certain amphibian species is often presumed to be mutualistic. However, the existence of a mutualism has only been experimentally tested and established in two closely related ambystomatid salamanders. These experiments showed a positive correlation between intracapsular algal density and embryonic growth, survival, hatching synchrony, and hatchling body size. Oophila has been documented within egg capsules of a growing number of amphibian species, including several frogs in the family Ranidae. However, the nature and extent of this relationship remains unclear. Ranid eggs are better oxygenated than ambystomatid eggs, …

Scale And Habitat Effects On Measurement Of Streptomyces Biogeography And Biodiversity, Terilyn A. Stoflet

Cal Poly Humboldt theses and projects

Bacteria in the genus Streptomyces are detected in most soils around the world, as well as on and in seeds, plants, animals, insects and the wind. Currently, more than 700 valid species of Streptomyces have been identified worldwide. Streptomyces produce the majority of antibiotics, antivirals and antifungals, as well as important agricultural bioactive molecules due to their unique genetic capabilities. Their distinct genetic abilities allow them to produce an unlimited amount of biosynthetic gene clusters, or BGC’s. Although many compounds come from Streptomyces, scientists have not discovered the biogeographic patterns of this genus. The biogeography of Streptomyces is a …

Fueling Identities: A Study Of Ethnic And Athletic Identities On Dietary Choices, Tally Chavez

Cal Poly Humboldt theses and projects

This study examines the intersectionality of athletic and ethnic identities and their influence on food choices among college-aged active individuals. Using the Multigroup Ethnic Identity Measure (MEIM), Athletic Identity Measurement Scale (AIMS), and Athlete Food Choice Questionnaire (AFCQ), this research explores how these identities impact nutritional attributes, usual eating practices, and performance-related food choices in a sample of 109 participants (58% female, mean age = 25.02 years) from diverse ethnic backgrounds. The hypothesis that a salient athletic identity combined with a salient ethnic identity would predict food choices prioritizing nutritional attributes was supported, suggesting that individuals with both identities salient …

Simulated Effects Of Postpartum Depression On Maternal-Infant Bonding: Mediated By Reward-Related Responses To Infant Facial Cuteness, Caitlin Harp

Cal Poly Humboldt theses and projects

Infant cuteness (facial cuteness in particular) is linked to evolutionary adaptations to motivate caretaking and protective behaviors (Kringelbach et al., 2008). Previous neuroimaging work has demonstrated that infant cuteness activates reward-related regions in the brain (Glocker et al., 2009) and behavioral work suggests that the reward value of cuteness is linked to maternal tendencies (Hahn et al., 2015). It is estimated that 15% of new mothers experience postpartum depression (PPD) (Wisner et al., 2013), which impacts the mesolimbic system and is linked to anhedonia (i.e., reduced ability to experience pleasure). Based on the above literature, this study used a simulated …

Assessing Community Perspectives To Inform Kelp Forest Restoration And Management: The Case Of Mendocino Coast, California, Jocelyn Enevoldsen

Cal Poly Humboldt theses and projects

In coastal Mendocino County, California, a multi-year marine heatwave event kicked off a dramatic ecosystem transformation that led to a near-total loss of bull kelp forests. People who relied on the local kelp ecosystems were affected and facing decisions about how to respond to the kelp ecosystem transformation. Rigorous assessments that are inclusive of local perspectives, values, and preferences could inform efforts related to kelp forest ecosystem management, conservation, and restoration. My research focused on answering the following questions: (1) What are the ways that people are connected to kelp ecosystems on the Mendocino coast? (2) What are community members’ …

Interactions Between New Zealand Mud Snails (Potamopyrgus Antipodarum) And Toxic Cyanoabacteria (Anabaena) In Baduwa’T (Mad River), Humboldt County, California, Cecilia F. Kennelly

Cal Poly Humboldt theses and projects

Invasive species in freshwater systems are circulated around the globe, wreaking havoc on natural communities. The New Zealand mud snail (Potamopyrgus antipodarum) is a very successful aquatic invader that has established populations in freshwater streams, lakes, and rivers around the globe. The goal of this project was to evaluate the interactions of invasive New Zealand mud snails (NZMS) and toxic cyanobacteria Anabaena in the Mad River in Humboldt County, California. These two species of concern are found in similar habitats along the river, but their whether NZMS consume Anabaena or affect toxin production is unknown. First, I conducted …

Barn Owls Exert Top-Down Effects On The Abundance And Behavior Of Rodent Pests, Katherine C. Larson

Cal Poly Humboldt theses and projects

Predators can exert top-down effects on their prey by direct consumption, by imposing risk of predation, or a combination of both. However, empirical evidence for these effects is mixed and inconsistent. Barn owls in agriculture present a system with attributes that should, according to theory, lead to strong top-down effects, but research is limited and the distinction between effects on prey abundance and behavior remains unresolved. Understanding the top-down effect of predators on pests is a cornerstone of integrated pest management and important where barn owls may contribute to the control of rodents on farms. Vegetation can mediate the top-down …