Digital Commons Network^™

The Ghostly Angel In The Haunted Home: The Haunted House As A Metaphor For A Woman's Body In Crimson Peak, Andrea I. Amado-Fajardo

Theses and Dissertations

Crimson Peak (2015, dir. Guillermo del Toro), often overshadowed by del Toro's more critically acclaimed filmography, deserves to be acknowledged for its central trauma metaphor and its nuanced approach to gender. Far from being merely a horror movie fueled by disturbing sequences such as those found in contemporary supernatural horror films, Crimson Peak slowly unravels how Allerdale Hall parallels the film's female leads as they house and live with ghosts, revenants of a traumatic past. This essay explores the personification of the haunted house as a metaphor for the personified trauma that resides in a woman's body using Crimson Peak …

Development Of A Real-Time Convolution System To Simulate Speech In Different Rooms For The Study Of Vocal Strain, Bethany E. Wu

Theses and Dissertations

Due to prevalent vocal health issues in teachers, the acoustics of K-12 classrooms has become a topic of study in acoustics. One way to understand the effects of a classroom's physical space on speech is with vocal effort studies. This thesis aims to enable these studies, without the need to move a talker from room to room, by creating auralizations through real-time convolution of speech with oral binaural room impulse responses (OBRIRs). These auralizations can be used to test talkers inside an anechoic chamber as they experience speaking in different acoustical environments. A system that can successfully execute convolution in …

Toward A Broader Theocentric Environmentalism, Melvin L. Otey

Duke Environmental Law & Policy Forum

No abstract provided.

Next Steps In Online Courts: Accelerating Access Tojustice Through Court Technology, J.J. Prescott

Alaska Law Review

For more than a decade, state courts have been expanding access to justice by adopting online dispute resolution (ODR) platforms and other outward-facing communication technologies. At a deep level, these reforms aim at improving society by bolstering the rule of law. At a surface level, these innovations recognize that the justice system works better when courts and law are easier and less costly to understand and use. In important respects, these efforts have been a success. The accessibility of many state courts is considerably more robust today than it was ten years ago, at least for small-stakes cases, like traffic …

Alaska's Healthcare Markets: The Free Market Is Nota "Cure", Katie Raya

Alaska Law Review

Healthcare reform in the United States requires a nuanced approach to improve quality and access while managing costs—a challenge particularly pronounced in Alaska. Despite being the highest spender on healthcare globally, the U.S. fails to deliver commensurate health outcomes, with Alaska exemplifying these systemic issues. The state faces the highest healthcare costs in the nation yet performs poorly in quality and access metrics. This situation has prompted urgent legislative scrutiny of existing policies, such as the Certificate of Need (CON) Law and the 80th Percentile Rule. This Note critically evaluates the argument that deregulating Alaska's healthcare market will lead to …

Glacial Progress: Thawing The Path To A Law School In Alaska, Kathrine Coonjohn

Alaska Law Review

My contribution to this symposium is clear: to advocate for the establishment of an Alaskan law school. As the only state in the nation without one Alaska keenly suffers the repercussions of this absence. The resulting void creates shortages of legal professionals, reduces opportunities for continuing legal education, cultural and community disconnection, and contributes to brain drain. Further, it undermines the state's legal infrastructure and limits access to justice. Despite significant logistical and financial hurdles, including the high costs of establishment and sustainability concerns, the need for a local legal institution is undeniable, and this need will only grow more …

Disgusted Judges And Domestic Violence, Jessica Miles

Seton Hall Law Review

No abstract provided.

Enhancing Graph Neural Networks By Editing Graphs, Jiayu Li

Dissertations - ALL

Graphs are pervasive in both the natural world and various domains of science and engineering. Numerous advanced classifiers, such as Graph Neural Networks (GNNs), have been developed to perform node classification on these graphs. However, as graphs become denser with an increasing number of edges, GNNs often suffer from suboptimal generalization performance due to the presence of task-irrelevant connections. These redundant connections can introduce noise, consume excessive computational resources, and degrade performance. Identifying and preserving critical connections in large-scale graphs, while pruning unnecessary ones, is crucial for enhancing the efficiency and accuracy of GNNs in node classification, particularly for GCNs. …

Peptides And Metalloproteins: Evolution, Catalysis And Material Design, Dona Imanga Upamadi Edirisinghe

Dissertations - ALL

Peptide hydrogels are an important class of biomaterials that have gained significant attention in recent years. The stimuli responsive materials change their properties in response to pH, redox, temperature and enzymes and this property allowed us to design the materials with tunable properties based on their end application. This dissertation reports the de novo design, synthesis and characterization of short chain peptide sequences and optimizations of those in order to develop them into potential candidates in wound care and drug delivery applications. The investigation of these novel peptide sequences will open up new possibilities to tailor the properties through simple …

“Others, Please Specify”: The Lived Experiences Of Non-Catholic Senior High School Students Studying In A Catholic School, Awani Obhoo, Jadon Reilly G. Garde, Rishae Aeiouffee B. Alcaraz, Andrea Charlize D. Barte, Teresa M. Camarines

Sinaya: A Philippine Journal for Senior High School Teachers and Students

“Others, please specify” is a common option in demographic questions, like when asking respondents’ religious affiliation, that provides them “a text box to self-identify.” This study focused on the said context as it indicated the minority status of non-Catholic students in a predominantly Catholic school and underscored the distinct lived experiences of these students. The relatively small representation of non-Catholic senior high school students studying in Catholic schools piqued curiosity and prompted the need for a deeper examination of their lived experiences. This study aspired to contribute to the development of religious studies in the Philippines, particularly for non-Catholic students …

Ilaw Ng Ibang Tahanan: Transnational Mothering Practices Of Overseas Filipina Domestic Workers During The Covid-19 Pandemic, Arvin John C. Ramirez

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Filipino mothers traditionally serve as primary caregivers and, at times, as the main breadwinners for their families. With limited opportunities in the Philippines, many seek employment abroad, leaving their children behind. Data from the Philippine Statistics Authority indicated that female Overseas Filipino Workers (OFWs) often engage in elementary jobs, including domestic work and caregiving. The COVID-19 pandemic added a challenge in fulfilling their maternal needs since health and safety have become everyone’s priority. This study investigates the transnational mothering practices of overseas Filipina domestic workers during the pandemic and how these practices differ from those before the health crisis. Through …

Self-Agency As A Strategy In Emergency Remote Learning Among Filipino Grade 10 Students, John Cris C. Tababa, Paul Andrei C. Apo, Golden Grace R. Gammaru, Audrey S. Manaay, Kathrin Anne N. Nadua, James Fhonzy Angelo S. Fontillo

Sinaya: A Philippine Journal for Senior High School Teachers and Students

The Coronavirus disease 2019 pandemic significantly influences students' educational attainment as they actively find and rationalize knowledge obtained from emergency remote learning. As a response, the agency or the ability to regulate one’s learning provides the students with the ability to believe in themselves. Still, it also necessitates the deliberate consideration to create a plan of action and modify it as required to achieve one's objectives. This study obtained knowledge from emergency remote learning (ERL) experiences of Filipino Grade 10 Students in their Social Studies class. The researchers employed a phenomenological approach to understand the self-agency practices of Grade 10 …

Citation Practices Of Contrasting Cultures In Q1 Journal Articles, April Rose C. Gonzales

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Citation is a distinguishing feature in research writing that every researcher must include to ensure credible ethical research. Citing sources is necessary as it provides credit to the original author, refers to previous findings, sets credibility, and enables sustainability of the topic. However, studies least consider culture as an element that influences citation beliefs and practices. Most literature holds a lack of language proficiency as the culprit for poor citation skills. Drawing from Hofstede's Cultural Dimension theory (2011) and Lewis’ (2006) Cultural Behaviour in Relation to Writing, this study explores the influence of culture on citation practices with the hope …

Exploring Student Engagement In A Blended And Gamified Statistics And Probability: Designed With Learning Styles And Player Types, Reymund R. Gonowon

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Educators are called to contribute towards achieving SDG 4: Quality Education. A major determinant in achieving this goal is providing learners with essential skills such as analyzing and interpreting data, making inferences, and driving evidence-based decisions which are the expected competencies in Statistics and Probability (STATPRO), one of the core subjects of the senior high school curriculum in the Philippines. To progress towards SDG 4, achieving the learning competencies of STATPRO is vital, however engaging students in a blended learning environment may be challenging. This study aims to explore the behavioral engagement of students in a gamified STATPRO class through …

Defining The Social Licence Of Large Language Models In Healthcare, Robin L. Pierce, Jack Gallifant, Ashley Cordes, Amelia Fiske, Matilda Dorotic, Mataroria Lyndon, Shrey Jain, Joe Zhang, Judy Gichoya, Leo Anthony Celi

Seattle Journal of Technology, Environmental, & Innovation Law

As Large Language Models (LLMs) continue to grow and evolve, the ethical, social, and legal challenges they present, especially in terms of data use and sharing, come sharply into focus. Particularly in high-risk domains like healthcare, where the sensitivity of data is pronounced, and the ramifications of data leakages or misuse are profound. These licenses, envisioned to address the complexities introduced by LLMs, still grapple with barriers that hinder their full potential: notably, the absence of authoritative regulatory bodies, ambiguities in defining what constitutes 'sufficient public benefit', issues of data sovereignty, and dilemmas surrounding responsibility and liability. Herein, we delve …

Protocol For Culturing Patient-Derived Organoids Of Cervical Cancer, Rui Wang, Timothy Harris, Dalissa Negrón-Figueroa, David Lo, Allison Judge, D'Shaunique Walters, Bo Jiang, Lauren E Colbert

Faculty, Staff and Student Publications

Herein, we present a protocol for culturing patient-derived organoids (PDOs) of cervical cancer that includes workflows for tumor biopsy/resection tissue and cytobrush-sampled cells. We describe steps for PDO culture initiation, including rinsing, gentle dissociation, Lymphoprep separation, and cell assessment, as well as seeding cells from surgical and cytobrush tissue digestion. We then provide guidance on PDO maintenance and passage and techniques for producing conditioned medium. Overall, this protocol serves as a valuable guide for establishing and maintaining cervical cancer PDOs. For complete details on the use and execution of this protocol, please refer to Colbert et al.

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Final Bpsou Insufficiently Reclaimed Sites Belle Of Butte (Bres No. 8 & Ur-39) Remedial Action Work Plan (Rawp) Request For Change Ir-2024-Ra-02 (Dated December 19, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Graduate Competencies Under The Thai Qualifications Framework For Higher Education In Educational Administration, Sumet Ngamkanok

Journal of Education Studies

This research aimed to 1) study graduate competencies under the Thai Qualifications Framework for higher education in educational administration; 2) develop indicators for developing graduate competency for higher education in educational administration, 3) create a competency development manual for graduates under the Thai qualifications framework for higher education in educational administration. Research instruments included a semi-structured interview form for collecting data and experts interview conclusions to develop indicators and create the questionnaire for evaluation and focus group. There were three stages of the research procedures: 1) studying competency components of graduates under the Thai Qualifications Framework in educational administration; 2) …

The Needs For Developing High-Efficiency Learning Management In The Digital Era, Kanchit Pimjai, Duangkamol Traiwichitkhun

Journal of Education Studies

This research aims to 1) study the conceptual framework for high-efficiency learning management in the digital era, and 2) investigate the needs for developing high-efficiency learning management in the digital era. The study employs a mixed-methods research design divided into two phases. Phase 1 involves qualitative research to address the conceptual framework for high-efficiency learning management in the digital era, with data collected from four selected experts using purposive sampling. The research tool was an interview guide, and the qualitative data was analyzed through content analysis, categorization, and summarization of findings. Phase 2 involves quantitative research to address the needs …

Design And Exploration Of Virtual Multi-Scene Classroom Based On Xr Technology, He Shuang

Journal of Education Studies

With the advent of the global post-epidemic era, the online and offline hybrid teaching mode and virtual learning environment will become the development trend of curriculum teaching and future teaching space. This virtual reality technology has many application cases in the design and business fields, which shows that the multi-scene application based on XR virtual technology is relatively mature and feasible. This study designs experiments for the on-spot teaching space that integrates virtual and reality. The author conducts multi-scene design simulation through the 3D multi-scene software, with the construction of the physical environment, and the recording and tracking of offline …

Fda Approval Of Zuranolone: A Breakthrough Treatment For Postpartum Depression, Connor Dains, Makayla Eversole, Kiley Devoll, Daniella Egbujor, Marisa Petrunich, Madilyn Paphanchith, Joshua Honaker, Samantha Mccord, Manoranjan D'Souza

Pharmacy and Wellness Review

Postpartum depression (PPD) is a serious medical condition that increases the risk of postpartum mortality and affects the ability of a postpartum individual to take care of their newborn. Until 2023, intravenously-administered brexanolone was the only Food and Drug Administration (FDA)-approved medication for PPD. Brexanolone’s route of administration poses significant barriers to accessibility and convenience. Other treatment options, such as psychotherapy and antidepressants, often require long-term commitment and may not provide rapid relief for severe symptoms. In August 2023, the FDA approved zuranolone as an oral medication for PPD, which enhances treatment accessibility and offers patients a more flexible, outpatient …

Beyond Bindis, Bhajis, Bangles And Bhangra: Promoting Multiculturalism In Primary Schools In Predominantly White British Places, Suparna Bagchi

School of Law, Humanities and Social Sciences

Twenty-first-century education as a powerful means of knowledge will possibly be shaped by the emphasis it places on having classrooms that are race-conscious and multicultural. The present article is based on a doctoral study that explores an under-researched area: experiences and understanding of multiculturalism in mainstream primary schools situated in the predominantly White places of Southwest England. The study was underpinned by a sociocultural theoretical framework; data were collected through semi-structured interviews with the adult participants, students’ classroom activities, and documentary analysis of school displays. The article focuses on the data generated from the students’ classroom activities. Findings show differences …

Engineering Biomaterial Interfaces For Microbial Control, Yikang Xu

Dissertations - ALL

Since its inception as early as ancient Chinese placing bamboo pegs in place of missing teeth over 4,000 years ago, biomaterials have been an indispensable component of medical tools at human’s disposal. While early implants rely solely on the material properties themselves, modern devices have become much more than just materials. Topographic features, coatings, surface energy, and even embedded electronics have all added dimensions to the complexity of biomaterials and medical devices. Interaction between these materials and host cells and tissues, as well as microbes that can cause infections. Although well recognized for its significance, controlling biomaterial associated infections is …

Privacy Protection In Machine Learning Via Exploitation Of Constrained Adversarial Evasion, Brian Testa

Dissertations - ALL

Deep neural networks are extensively applied to real-world tasks. In many cases, the data feeding these tasks are human generated content, which emphasizes the criticality of privacy and data protection. The diverse modalities of this user data provide fertile ground for 3rd parties to monetize a user’s data. This work considers two such modalities: user speech when interacting with smart speaker voice assistants (VAs) and images shared with online service providers. In these cases, the user would like to support some form of machine learning (ML) inference without allowing others. A user interacting with a smart speaker would like the …

Estranged Bodies, Race, And Sectarianism: An Historical Bioarchaeology Of Ottoman And French Beirut, Tony John Chamoun

Dissertations - ALL

Modern imperial formations involve a violent reconfiguring of difference that is inseparable from the everyday. Modern-world archaeology as a project that studies interlocking vicissitudes of modernity globally has done much to elucidate the varied social orders and politics of knowledge through which such reshuffling occurs. Yet largely missing from this conversation is the bioarchaeology of the Middle East and North Africa region; as such, the very bodies who shaped and were shaped by modern conditions in a major world circuit are also missing. To advance a more global and grounded investigation of modernity, I turn to the port city of …

Vimentin Inside And Outside The Cell: From Cell Spreading To Nuclear Mechanics To Covid-19, Maxx Swoger

Dissertations - ALL

Cells are constantly subjected to both external forces encountered from the extracellular environment and internal stresses generated by the cell necessary to migrate and undergo healthy cellular function. Central to the ability of cells to both generate and mediate forces is the cell cytoskeleton, which forms the muscles and bones for cells. There are three main components of the cell cytoskeleton: microtubules, actin, and intermediate filaments. The role of actin and microtubules in cell function, particularly force generation and mediation have been well studied; however, the role of intermediate filaments is less understood. Intermediate filaments represent a broad and diverse …

Formulation And Characterization Of Biologics – From Sirna To Monoclonal Antibodies, Chinmay M. Jogdeo

Theses & Dissertations

Biologics are a rapidly growing class of therapeutics, encompassing a wide range of modalities, with gene therapy products and monoclonal antibodies (mAbs) constituting the majority. Proper formulation and characterization of these complex therapeutics is crucial to ensure their safety and therapeutic efficacy.

This dissertation focuses on two main areas: the development of a novel renal-targeted siRNA delivery system and the assessment of structural and conformational stability of mAbs in a simulated subcutaneous (SC) environment.

The first part of this dissertation presents the synthesis and characterization of a novel renal-targeted polymer for selective siRNA delivery to injured kidneys. Inulin was modified …

Discrete Element Method For Mining Industrial Applications: Solving The Clumping Problem Caused By Bulk Cohesive Particles In An Iron Ore Beneficiation Process, Shuang Liu

McKelvey School of Engineering Graduate Student Theses & Dissertations

The discrete element method (DEM) is a widely used numerical approach for simulating and analyzing the behavior of granular materials in various applications. This research focuses on the iron ore beneficiation process, addressing the clumping issue in cohesive iron ores from existing crushing processes through a novel double-layered disperser design. The significance of this study lies in its potential to enhance the efficiency of the existing crushing phase and improve the linkage to subsequent purification stages that target smaller-sized iron ore pellets, thereby enhancing the overall efficiency of the ore beneficiation process and achieving significant energy savings. This research adopts …

Terpene Bioproduction From Non-Model Yeast: Omics Analysis And Metabolic Modeling For Guiding Scaleup Optimization, Alyssa Worland

McKelvey School of Engineering Graduate Student Theses & Dissertations

Sustainability efforts have driven significant advancements in synthetic biology, particularly through the development of microbial cell factories designed for waste reduction and resource conservation. This dissertation seeks to characterize a microbial biorefinery platform for the biosynthesis of terpene compounds from yeast, with an emphasis on the industrial bioconversion of waste lipids. Terpene compounds play crucial roles in various industrial applications; however, traditional methods of terpene production have sustainability and productivity challenges that could be overcome by using microbial biosynthesis. The yeast Yarrowia lipolytica is a microbial host well suited for converting waste oils into value-added terpenes due to its native …

Reimagining The Machine Vision Pipeline In Cyber Physical Systems For Trustworthiness And Efficiency, Adith Boloor

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cyber-physical systems (CPS), including autonomous vehicles, drones, and mobile robots, rely on intricate sensors, actuators, and machine learning algorithms to perceive the physical world and execute actions within their surroundings. In the context of vision-driven CPS, achieving this demands processing a substantial volume of visual data captured by on-board cameras. The data is subsequently channeled through digital processors and harnessed by deep neural networks for tasks such as image classification, object detection, and depth perception. This data-centric, machine-vision-infused CPS fosters intelligent decision-making, thereby enhancing overall system performance. Trustworthiness, encompassing the robustness of the entire machine-vision pipeline, and system-level efficiency are …