Digital Commons Network^™

Troglodyke's Delight: A Deep Listening Of Pauline Olivero's Troglodyte's Delight, Calum Robertson

Theses and Dissertations (Comprehensive)

Pauline Oliveros, renowned lesbian composer, left a legacy of experimental music and groundbreaking ideas about music and sound, both as maker and listener. She is best known for her concept of Deep Listening, the active engagement of listening to sound and being open to all possibilities, being receptive to the resonant currents emanating from the sounds, to go beyond hearing and to listen, to Deeply Listen, to the sounds, to experience fully those sounds. Deep Listening was inspired by an experience Oliveros had in a cistern in 1988, where beneath the earth she truly experienced listening and the sounds present …

Young Adult Stepchildren's Lived Experience Of Blended Family Adjustment During Adolescence: A Retrospective Descriptive Phenomenological Analysis, Azadeh Razbani-Tehrani

Theses and Dissertations (Comprehensive)

Abstract

Blended family adjustment is a common experience for many children and adolescents, given the commonality of blended families in our current times (Arat & Poortman, 2023; Ganong et al., 2020; George & Fernandez, 2014). The 2021 Canadian Census data showed that there were more than 500,000 blended families in Canada (Statistics Canada, 2022). Stepchildren in blended families, specifically adolescents, are members of the blended family most adversely impacted by blended family formation (Papernow, 2013; 2018). Despite the volume of valuable empirical literature on blended families and stepchildren (Ganong and Coleman, 2017; Hoffmann, 2002, 2006; Jeynes, 2007; Tillman, 2007; van …

Is Trust A Zero-Sum Game? What Happens When Institutional Sources Get It Wrong, Andrew Dawson

Theses and Dissertations (Comprehensive)

In the wake of the COVID-19 pandemic, trust in mainstream institutions is on the decline while people are increasingly turning to alternative media and conspiracy theories. Previous research has suggested that these trends may be linked, but the exact nature of the relationship is unclear. In a fractured informational environment, is trust a neutral process, where each source is judged independently, or is it in fact a zero-sum competition, where a loss for one side is a gain for the other? Across three experimental studies (N = 2,951) we examined how people react when a source makes a serious error, …

Elucidating Mechanisms Of Enhanced Dsrna-Nanophytoglycogen Innate Immune Responses In Healthy Human Cells, Nicholas Jadaa

Theses and Dissertations (Comprehensive)

Immunostimulatory nucleic acids, such as long double-stranded RNA (ds)RNA, can stimulate innate immune responses in a non-sequence specific manner. These molecules are recognized by pattern-recognition receptors in the cytoplasm, endosome, and on the cell surface. Activation leads to the production of mediators of innate immune pathways, including type I interferon and proinflammatory cytokines. Although these receptors are present in all cells, their role in non-immune cells is often overlooked due to their lower level of responsiveness. Nanocarriers can enhance these nucleic acid-mediated responses, allowing for exploration of innate immune pathways in non-immune cells. Nanoparticles as carriers of nucleic acids can …

Queer Liberation In Young Adult Fantasy: An Analysis Of Rainbow Islands, Sydney Brouillard-Coyle

Theses and Dissertations (Comprehensive)

The purpose of this study was to explore how the theme of queer liberation can be represented in young adult fantasy novels. I conducted an in-depth analysis of the novel Rainbow Islands (Devin Harnois) utilizing the lenses of queer, transgender, intersectional, and narrative theory. In the novel Rainbow Islands, Harnois presents a utopia in which queer people are able to counter their oppressive realities by building systems of community that support one another; yet, the novel ends up replicating systems of oppression. Thus, Rainbow Islands offers a complex opportunity for analysis when considering the theme of queer liberation and how …

Parental Evaluations And Choice Of Math Apps For Their Young Children: Exploring The Impact Of Individual Differences, Nicola Urquhart

Theses and Dissertations (Comprehensive)

Well-designed math apps can have positive effects on young children’s math abilities (Bang et al., 2023; Griffith et al., 2019; Outhwaite et al., 2023), but research indicates that many commercially available math apps are not well designed (Dubé et al., 2019; Meyer et al., 2021). Studies also find that parents struggle to identify relevant features from app store descriptions (Montazami et al., 2022; Pearson et al., 2023). The purpose of the present research was to investigate how parents evaluate the apps themselves, and to test whether individual differences can affect parental app evaluations and decisions. In two parts of Study …

Cyberbullying: Media Construction And Framing Tactics In Pakistan, Asma Jamal

Theses and Dissertations (Comprehensive)

This thesis critically examines the portrayal of cyberbullying within Pakistan's top three newspapers, focusing on how these media outlets shape public discourse over the past five years. Employing an integrated approach using framing analysis and Fairclough’s Three-Dimensional Model, my research deconstructs how these newspapers utilize specific framing strategies to construct a narrative that not only informs but also subtly influences public perception and policy responses. The findings show that while the media highlights the roles of parents, educators, and law enforcement in combating cyberbullying, it also tends to reinforce traditional gender roles and overlook systemic solutions. I argue that the …

Language As Power: How Lgbtqia+ Gen-Z Use Language For Identity And Liberation, Kayci Resende-Abbott

Undergraduate Theses and Capstone Projects

Generation Z LGBTQIA+ individuals are tasked with challenging and overcoming generations of social and systemic oppression related to their identities. One of the primary methods they use to achieve this is through the language and labels they use in their daily lives. From the inception of new acronyms to new labels and language, this new generation of LGBTQIA+ individuals is looking to break out of the mold that was set for them by past generations. This study aims to investigate how LGBTQIA+ Gen-Z individuals utilize language in their everyday interactions to articulate and affirm their gender and sexuality. Through qualitative …

The Torch: College Of Arts & Sciences Program Newsletter, Spring 2024, College Of Arts & Sciences Honors Program

Torch Newsletter

No abstract provided.

Post-Conviction Disclosure In The Canadian Context, Alexandra Ballantyne, Tamara Levy, K.C.

All Faculty Publications

It is common knowledge that the criminal justice system is fallible and prone to human error. The most egregious of such errors is the conviction of an innocent person. While wrongful convictions have been acknowledged in Canada in the last few decades, they are mostly regarded as rare and extraordinary events.16 In response to this perception, experts have identified the challenge of determining the number of wrongful convictions and their exact causes.17 A 2019 study estimates that at least 85 people have been exonerated in Canada.18 The recent advent of the Canadian Registry of Wrongful Convictions creates a centralized location …

The Chinese Tax System: Where It Stands And How We Should Study It, Wei Cui

All Faculty Publications

This book chapter offers an overview of where China’s tax system stands, critically assesses recent scholarship on Chinese taxation, and urges researchers to attend more to normative questions of tax design (e.g., economic efficiency and redistribution). After surveying major tax instruments deployed in China today, the chapter reviews recent studies of taxation’s impact on the Chinese economy, arguing that such scholarship often falls short of providing systematic support for policy analyses, and that ignoring normative questions in tax design leads to poor conceptual framing in positive analyses. The chapter then considers some themes at the intersection between Chinese political institutions …

Evaluation Of The Physicochemical Properties And Soil Biogeochemistry Of Fire Residues, Lingqun Zeng

Electronic Theses & Dissertations (2024 - present)

Wildland fire is a main driving force in the Earth system and affects ecosystem properties and processes across spatio-temporal scales. The burning of biomass and production of solid fire residues (conventionally termed fire ash) that are a mixture of completely and incompletely burned materials (inorganic ash and pyrogenic carbon), represent the direct and prominent changes by fires. Cycling of the fire residues is an integral component of elemental cycles and can mediate other biogeochemical processes.

This dissertation aims to fill important knowledge gaps in understanding the disturbance of wildland fires to biogeochemical processes in soils. First, this work characterized and …

Ensemble Storytelling In How To Get Away With Murder, Deidre Pribram

Communications: Faculty Publications

The usually large number of scriptwriters associated with contemporary television’s dramatic serials renders the attribution of primary creative or authorial ownership particularly difficult.  The result has been to ascribe written imprimatur for a series to the head writer/showrunner.  Yet, there are other, conflicting ways to understand authorial influence or control over a TV series, for example, through producing entities.  Thus, How to Get Away with Murder (2014-2020) is a Shondaland production, part of the Shonda Rhimes collection, and readily identifiable as a significant entry in the Rhimes compendium.

Although an executive producer for How to Get Away with Murder, but …

Gender And Nostalgia In Period Drama: The Marvelous Mrs. Maisel And Mad Men, Deidre Pribram

Communications: Faculty Publications

The Marvelous Mrs. Maisel (2017-2023) and Mad Men (2007-2015) share a common genre, location, and era.  Both are period dramas, set in New York City, as the waning 1950s transition into the 1960s.  Additionally, both television serials address changing cultural conditions, especially surrounding gender.  Yet, when analyzed through the prism of nostalgia, the two programs deviate in significant ways.  This essay uses Grainge’s (2000) distinction between nostalgia as mood and nostalgia as aesthetic style, applying it to the two television serials.  It also incorporates concepts of nostalgia as critique (Cook, 2005), as well as imagined nostalgia as the longing “for …

Plasmid-Borne Biosynthetic Gene Clusters Within A Permanently Stratified Marine Water Column, Paraskevi Mara, David Geller-Mcgrath, Elizabeth A. Suter, Gordon T. Taylor, Maria G. Pachiadaki, Virginia P. Edgcomb

BCES: Faculty Publications

Plasmids are mobile genetic elements known to carry secondary metabolic genes that affect the fitness and survival of microbes in the environment. Well-studied cases of plasmidencoded secondary metabolic genes in marine habitats include toxin/antitoxin and antibiotic biosynthesis/resistance genes. Here, we examine metagenome-assembled genomes (MAGs) from the permanently-stratified water column of the Cariaco Basin for integrated plasmids that encode biosynthetic gene clusters of secondary metabolites (smBGCs). We identify 16 plasmid-borne smBGCs in MAGs associated primarily with Planctomycetota and Pseudomonadota that encode terpenesynthesizing genes, and genes for production of ribosomal and non-ribosomal peptides. These identified genes encode for secondary metabolites that are …

Introduction (To Emotional Expressionism), E. Deidre Pribram Ph.D.

Communications: Faculty Publications

The primary purpose of Emotional Expressionism: Television Serialization, The Melodramatic Mode, and Socioemotionality is to explore the forms, functions, and nuances of emotions in popular, mediated narratives. Clearly, emotions constitute a key means by which audiences experience and make sense of narrative media, in that mediated stories make compelling arguments or take up resonant positions through their emotional methods and meanings. The value of developing an emotional template for screen media lies in generating new analytical and interpretative approaches to narrative aesthetics, especially in terms of their pains and pleasures. As this study seeks to demonstrate, emotional analysis opens up …

Education And Religion In Shaping Support For Same-Sex Relations: Considering Differences Over Time And Across Geographical Areas, Amy Adamczyk, Ashely French

Publications and Research

Across the world, attitudes about same-sex relationships have become rapidly more supportive. While education is typically viewed as a liberalizing force, religious beliefs are often seen as restricting more tolerant perspectives and contributing to more conservative attitudes in general. Focusing on the United States this study examines the roles of religion and education, as individual and group properties, for understanding disapproval of same-sex relationships. Drawing on restricted information that makes it possible to identify where General Social Survey respondents lived, we find that graduating from college is associated with more support, but has less of an effect on Evangelicals and …

Revamping Email Communications: A Review Of Five Free Email Design Platforms, Karen Okamoto

Publications and Research

This article reviews five free online email design platforms that libraries can use to create visually appealing and engaging email newsletters and other email communications. The five platforms reviewed in this article – Beefree, Mosaico, Smore, Stripo, and Tabular – are assessed according to ease of use, the availability of pre-designed templates, and other features, such as the ability to add collaborators. This review begins with a summary of the library and marketing literature on email communications, including best practices, and ends with a brief overview of email marketing platforms and services.

Fa4sans-Gan: A Novel Machine Learning Generative Adversarial Network To Further Understand Ophthalmic Changes In Spaceflight Associated Neuro-Ocular Syndrome (Sans), Sharif Amit Kamran, Khondker Fariha Hossain, Joshua Ong, Ethan Waisberg, Nasif Zaman, Salah A Baker, Andrew G Lee, Alireza Tavakkoli

Faculty, Staff and Student Publications

PURPOSE: To provide an automated system for synthesizing fluorescein angiography (FA) images from color fundus photographs for averting risks associated with fluorescein dye and extend its future application to spaceflight associated neuro-ocular syndrome (SANS) detection in spaceflight where resources are limited.

DESIGN: Development and validation of a novel conditional generative adversarial network (GAN) trained on limited amount of FA and color fundus images with diabetic retinopathy and control cases.

PARTICIPANTS: Color fundus and FA paired images for unique patients were collected from a publicly available study.

METHODS: FA4SANS-GAN was trained to generate FA images from color fundus photographs using 2 …

Sustained Pain And Macrophage Infiltration In A Mouse Muscle Contusion Model, Ibdanelo Cortez, Caitlyn M Gaffney, Caitlin V Crelli, Eric Lee, James M Nichols, Hoang Vu Pham, Syed Mehdi, Jelena M Janjic, Andrew J Shepherd

Faculty, Staff and Student Publications

Introduction/aims: Prior studies have emphasized the role of inflammation in the response to injury and muscle regeneration, but little emphasis has been placed on characterizing the relationship between innate inflammation, pain, and functional impairment. The aim of our study was to determine the contribution of innate immunity to prolonged pain following muscle contusion.

Methods: We developed a closed-impact mouse model of muscle contusion and a macrophage-targeted near-infrared fluorescent nanoemulsion. Closed-impact contusions were delivered to the lower left limb. Pain sensitivity, gait dysfunction, and inflammation were assessed in the days and weeks post-contusion. Macrophage accumulation was imaged in vivo by injecting …

Usp22 Overexpression Fails To Augment Tumor Formatiaon In Mmtv-Erbb2 Mice But Loss Of Function Impacts Mmtv Promoter Activity, Xianghong Kuang, Andrew Salinger, Fernando Benavides, William J Muller, Sharon Y R Dent, Evangelia Koutelou

Faculty, Staff and Student Publications

The Ubiquitin Specific Peptidase 22 (USP22), a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) histone modifying complex, is overexpressed in multiple human cancers, but how USP22 impacts tumorigenesis is not clear. We reported previously that Usp22 loss in mice impacts execution of several signaling pathways driven by growth factor receptors such as erythroblastic oncogene B b2 (ERBB2). To determine whether changes in USP22 expression affects ERBB2-driven tumorigenesis, we introduced conditional overexpression or deletion alleles of Usp22 into mice bearing the Mouse mammary tumor virus-Neu-Ires-Cre (MMTV-NIC) transgene, which drives both rat ERBB2/NEU expression and Cre recombinase activity from the MMTV promoter resulting …

Using Evidence-Based Scientific Research To Influence Dietary Behavioral Change: Taking A Look In The Mirror, Clifton P. Bueno De Mesquita, Ylenia Vimercati Molano, Lara Vimercati, P. Jacob Bueno De Mesquita

Arts & Sciences Faculty Publications

Science can provide accurate information to society to inform decision-making and behavior. One contemporary topic in which the science is very clear, yet behavioral change has lagged, is climate change mitigation. Climate change scientists use evidence-based research to advocate to the public to adopt emission-reducing behaviors in various sectors such as transportation and food. However, scientists themselves often do not change their own behaviors according to the scientific consensus. We present a case study of a group of natural sciences PhD students, who, when presented with evidence and an opportunity for a behavioral change with implications for climate change mitigation, …

A Second Look At Active Shooter Events: Expanding Our Understanding Of Key Factors, Kyle Gamache, Matt Zaitchik, Judith Platania, Cecelia Coslovi, Willem Pontbriand

Arts & Sciences Faculty Publications

In the current study, we investigate active shooter events (ASEs) with emphasis on expanding our understanding of key factors involved in these events. The impetus for this study is a 2015 exploration (Gamache et al., 2015) that highlighted common perpetrator and event characteristics in ASEs occurring in the US prior to 2014. Since the 2015 study, mass-shooting events have moved from tragic, isolated incidents, to a phenomenon that is widely discussed in the media and highly politicized. Our goal was to investigate continued trends, if any exist, and to compare our current sample of ASEs to the sample utilized in …

Awareness And Interest In Cannabis Use For Cancer Management Among Cancer Survivors, Ikponmwosa Osaghae, Rajesh Talluri, Onyema Greg Chido-Amajuoyi, Kimberson Tanco, Dimpy P Shah, Mala Pande, Sanjay Shete

Faculty, Staff and Student Publications

BACKGROUND: We examined the awareness, interest, and information sources relating to cannabis use for cancer management (including management of cancer symptoms and treatment-related side effects) and determined factors associated with cancer survivors' awareness and interest in learning about cannabis use for cancer management.

METHODS: This was a cross-sectional study of adult cancer survivors (N = 1886) receiving treatment at a comprehensive cancer center. Weighted prevalence and multivariable logistic regression analyses were conducted.

RESULTS: Among cancer survivors, 88% were aware and 60% were interested in learning about cannabis use for cancer management. Common sources of information to learn about cannabis use …

Multiple Unfolded Protein Response Pathways Cooperate To Link Cytosolic Dsdna Release To Stimulator Of Interferon Gene Activation, Tiancheng Hu, Yiping Liu, Jeremy Fleck, Cason King, Elaine Schalk, Zhenyu Zhang, Andrew Mehle, Judith A Smith

Faculty, Staff and Student Publications

The double-stranded DNA (dsDNA) sensor STING has been increasingly implicated in responses to "sterile" endogenous threats and pathogens without nominal DNA or cyclic di-nucleotide stimuli. Previous work showed an endoplasmic reticulum (ER) stress response, known as the unfolded protein response (UPR), activates STING. Herein, we sought to determine if ER stress generated a STING ligand, and to identify the UPR pathways involved. Induction of IFN-β expression following stimulation with the UPR inducer thapsigargin (TPG) or oxygen glucose deprivation required both STING and the dsDNA-sensing cyclic GMP-AMP synthase (cGAS). Furthermore, TPG increased cytosolic mitochondrial DNA, and immunofluorescence visualized dsDNA punctae in …

Development And Initial Validation Of A Hospital Stress Questionnaire, Daniel M Ford, Rebecca Lawton, Elizabeth Travis, Elizabeth A Teale, Daryl B O'Connor

Faculty, Staff and Student Publications

BACKGROUND: Hospitalisation can be a traumatic experience, where inpatients are exposed to an abundance of physical and psychological stressors. Evidence suggests that these hospital-related stressors negatively impact health: a phenomenon known as post-hospital syndrome. The current study aimed to identify hospital-related stressors, and to develop and provide initial validation for a new measure of in-hospital stress.

METHODS: Measure development occurred in three stages: (i) semi-structured interviews, (ii) item generation, and (iii) pilot testing. Twenty-one patients were interviewed regarding their recent hospital experiences, and a list of hospital-related stressors was produced. These stressors were compiled into a questionnaire and piloted on …

Image-Guided Deployment And Monitoring Of A Novel Tungsten Nanoparticle-Infused Radiopaque Absorbable Inferior Vena Cava Filter In A Swine Model, Erin Marie San Valentin, Jossana A Damasco, Marvin Bernardino, Karem A Court, Biana Godin, Gino Martin Canlas, Adam Melancon, Gouthami Chintalapani, Megan C Jacobsen, William Norton, Rick R Layman, Natalie Fowlkes, Stephen R Chen, Steven Y Huang, Marites P Melancon

Faculty, Staff and Student Publications

PURPOSE: To improve radiopacity of radiolucent absorbable poly-p-dioxanone (PPDO) inferior vena cava filters (IVCFs) and demostrate their effectiveness in clot-trapping ability.

MATERIALS AND METHODS: Tungsten nanoparticles (WNPs) were incorporated along with polyhydroxybutyrate (PHB), polycaprolactone (PCL), and polyvinylpyrrolidone (PVP) polymers to increase the surface adsorption of WNPs. The physicochemical and in vitro and in vivo imaging properties of PPDO IVCFs with WNPs with single-polymer PHB (W-P) were compared with those of WNPs with polymer blends consisting of PHB, PCL, and PVP (W-PB).

RESULTS: In vitro analyses using PPDO sutures showed enhanced radiopacity with either W-P or W-PB coating, without compromising the …

Cardiovascular Risk Factors In Sheehan's Syndrome: A Case-Control Study, Mayur Agrawal, Subhash C Yadav, Swish K Singh, Sheo Kumar, Krishnarpan Chatterjee, Naveen K Garg

Faculty, Staff and Student Publications

INTRODUCTION: Obesity, dyslipidaemia and insulin resistance are associated with hypopituitarism. The association between these conditions and Sheehan's syndrome (SS) caused by post-partum pituitary gland necrosis is poorly understood. This study aimed to assess cardiovascular risk surrogate markers in SS patients, and we compared clinical, biochemical and radiological testing with healthy controls.

METHODS: In this cross-sectional study, we studied 45 patients with SS on standard replacement therapy and compared them with healthy controls. All subjects underwent anthropometric, inflammatory marker and hormonal measurement (adrenocorticotropic hormone (ACTH), stimulated cortisol, insulin-like growth factor-1 (IGF-1), thyroxine (T4), follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol (E2), …

Single-Cell Rna Sequencing Analysis Identifies Acute Changes In The Tumor Microenvironment Induced By Interferon Α Gene Therapy In A Murine Bladder Cancer Model, Alexis R Steinmetz, Morgan Pierce, Alberto Martini, Come Tholomier, Ganiraju Manyam, Yan Chen, Akshay Sood, Jonathan J Duplisea, Burles A Johnson, Bogdan A Czerniak, Byron H Lee, Chinnaswamy Jagannath, Seppo Yla-Herttuala, Nigel R Parker, David J Mcconkey, Colin P Dinney, Sharada Mokkapati

Faculty, Staff and Student Publications

Introduction: Nadofaragene firadenovec (Ad-IFNα/Syn3) is now approved for BCG-unresponsive bladder cancer (BLCA). IFNα is a pleiotropic cytokine that causes direct tumor cell killing via TRAIL-mediated apoptosis, angiogenesis inhibition, and activation of the innate and adaptive immune system. We established an immunocompetent murine BLCA model to study the effects of murine adenoviral IFNα (muAd-Ifnα) gene therapy on cancer cells and the tumor microenvironment using a novel murine equivalent of Nadofaragene firadenovec (muAd-Ifnα).

Methods: Tumors were induced by instilling MB49 cells into the bladders of mice; luciferase imaging confirmed tumor development. Mice were treated with adenovirus control (Ad-Ctrl; empty vector), or muAd-Ifnα …

Gene Expression Of Kynurenine Pathway Enzymes In Depression And Following Electroconvulsive Therapy, Karen M. Ryan, Myles Corrigan, Therese M. Murphy, Declan M. Mcloughlin, Andrew Harkin

Articles

Objective: This study aimed to investigate changes in mRNA expression of the kynurenine pathway (KP) enzymes tryptophan 2, 3-dioxygenase (TDO), indoleamine 2, 3-dioxygenase 1 and 2 (IDO1, IDO2), kynurenine aminotransferase 1 and 2 (KAT1, KAT2), kynurenine monooxygenase (KMO) and kynureninase (KYNU) in medicated patients with depression (n = 74) compared to age- and sex-matched healthy controls (n = 55) and in patients with depression after electroconvulsive therapy (ECT). Associations with mood score (24-item Hamilton Depression Rating Scale, HAM-D24), plasma KP metabolites and selected glucocorticoid and inflammatory immune markers known to regulate KP enzyme expression were also explored. Methods: HAM-D24 was …