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2024

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Factors Contributing To Chronic Student Absenteeism In Low Socioeconomic Urban Elementary Schools: An Analysis Of Multiple Stakeholders’ Perspectives, Kellen D. Conaway Dec 2024

Factors Contributing To Chronic Student Absenteeism In Low Socioeconomic Urban Elementary Schools: An Analysis Of Multiple Stakeholders’ Perspectives, Kellen D. Conaway

Graduate Theses and Dissertations

The purpose of this study was to examine factors contributing to chronic student absenteeism in two lower socioeconomic urban elementary schools. This qualitative study was guided by two research questions: 1) What are stakeholders’ perspectives on chronic absenteeism at Mission and Lincoln Elementaries? and 2) What changes to practice or policy could improve attendance at Mission and Lincoln Elementaries? Research question one was answered via data collected from interviews with purposefully selected parents, teachers, administrators, social workers, and nurses. Analysis of interview data led to the identification of three themes which reflect stakeholders’ perspectives on chronic absenteeism at Mission and …


Synthesis Of Chemical Fuels And Feedstocks From Co2 For Extraterrestrial Applications, Samuel Keith Conlin Dec 2024

Synthesis Of Chemical Fuels And Feedstocks From Co2 For Extraterrestrial Applications, Samuel Keith Conlin

Graduate Theses and Dissertations

The reduction of CO2 into products for either the storage of renewable electricity or to act as a source of renewable feedstock for industry, is not economically feasible given the current costs of renewable energy. Significant amounts of work have gone into attempting to optimize both electrochemical and nonthermal plasma-based CO2 reduction systems in an attempt to reduce side reactions and improve energy efficiency in order to meet cost feasibility targets. These techniques can also be adapted for In-Situ Resource Utilization (ISRU) contexts, which are far less sensitive to the cost of renewable energy yet have more strenuous …


Multimodal Spectroscopy To Study Tumor Microenvironmental Changes In Vivo, April Mordi Dec 2024

Multimodal Spectroscopy To Study Tumor Microenvironmental Changes In Vivo, April Mordi

Graduate Theses and Dissertations

Every year there are millions of new cancer diagnoses and deaths worldwide. While great strides have been made in technologies and drugs for cancer treatment, there is still a need to understand tumor response to therapy as many patients still endure treatment failure after completing their treatment regimen. Current clinical imaging techniques for detecting response to therapy are utilized weeks to months after the course of treatment, and present limitations to measuring response during treatment. Optical spectroscopy techniques can help meet this need to determine the response of tumors to treatment as it allows for near real-time in vivo characterization …


Enhancing Smart Grid Security And Resilience Using Programmable Networks, Zheng Hu Dec 2024

Enhancing Smart Grid Security And Resilience Using Programmable Networks, Zheng Hu

Graduate Theses and Dissertations

The security and resilience of smart grids are essential to ensuring reliable and efficient energy distribution, especially as these cyber-physical systems grow more interconnected and complex. Supervisory Control and Data Acquisition (SCADA) systems play a critical role in smart grid operations by enabling essential infrastructure control and real-time monitoring. However, SCADA systems are highly vulnerable to modern cyber threats, which target weaknesses in industrial protocols and real-time data requirements.

This dissertation investigates the potential of programmable network technologies, with a focus on P4 (Programming Protocol-independent Packet Processors) switch, to deliver adaptable, in-network security solutions tailored to the needs of smart …


Exploring The Interplay Between Testosterone Levels And Gender Role Attitudes, Arial Bloshinsky Dec 2024

Exploring The Interplay Between Testosterone Levels And Gender Role Attitudes, Arial Bloshinsky

Graduate Theses and Dissertations

Traditional gender role attitudes align men with resource management and women with nurturing. The Challenge Hypothesis proposes that resource management is associated with higher testosterone levels, whereas nurturing is associated with lower testosterone levels. Therefore, traditional gender role attitudes may be associated with people’s testosterone levels. Furthermore, during the transition to parenthood, traditional gender role attitudes may become particularly salient, as shifting biological, social, and cultural roles during this transition make these attitudes an integral part of daily life. In this longitudinal study of expectant couples, participants completed a baseline survey and baseline session, during which they completed measures and …


Online Self-Directed Learning About Covid By Custodial Fathers In The U.S., Susan Bradley Dec 2024

Online Self-Directed Learning About Covid By Custodial Fathers In The U.S., Susan Bradley

Graduate Theses and Dissertations

The COVID pandemic was a time of unprecedented need for self-directed learning due to a conflagration of factors. These included the rapid global spread of the virus, leading to over 1.8 million deaths worldwide in 2020 alone according to the World Health Organization. In addition, traditional authorities such as the World Health Organization and U.S. Centers for Disease Control, along with individual health practitioners and institutions, failed to calm the panic due to a lack of agreement about recommended protections and treatments.

Simultaneously, due to COVID’s strain on the healthcare system, people were urged to refrain from visiting their doctors …


Black Lives Still Matter: Freedom Schools As An Embodiment Of Critical Literacy Through Reflection And Action, Elena M. Venegas, Lakia M. Scott Dec 2024

Black Lives Still Matter: Freedom Schools As An Embodiment Of Critical Literacy Through Reflection And Action, Elena M. Venegas, Lakia M. Scott

Bilingual and Literacy Studies Faculty Publications

The continuation of racial inequities in the United States has ignited the recent Black Lives Matter Movement, a protest of police brutality and gun violence. Black lives matter in public school classrooms, too—where students of color face barriers to equitable educational experiences. The Children's Defense Fund Freedom School program is a major component in developing critical literacy skills through critique, inquiry, and transformation through social justice and action. Critical literacy is enacted through identity—mainly as difference, self, consciousness, narrative, and positionality. Historical and contemporary relevance of Freedom Schools connects to the urgency of the Black Lives Matter Movement.


The Role Of Epigenetic Aberrations In The Cold Tumor Phenotype And Inflammatory Signaling In High-Risk Neuroblastoma, Pamela Morgan Watson Dec 2024

The Role Of Epigenetic Aberrations In The Cold Tumor Phenotype And Inflammatory Signaling In High-Risk Neuroblastoma, Pamela Morgan Watson

Alternative Theses and Dissertations (AETDs)

Neuroblastoma (NB) is a highly aggressive, heterogeneous disease that arises from the sympathetic nervous system (SNS) and originates from neural crest cells (NCCs) (1). NB is the most common extracranial cancer in pediatric accounts for 15% of pediatric cancer deaths (2). This high mortality rate is the result of the metastatic, immune evasive, and treatment resistant characteristics of the disease (3). It has been proposed that NB arises from blocks in differentiation during development, resulting in a mixture of two distinct cell types within the tumor: mesenchymal and adrenergic (Figure 1.1) (4,5). The adrenergic cell type is more differentiated, and …


Agchain: A Blockchain-Based Gateway For Trustworthy App Delegation From Mobile App Markets, Mengjie Chen, Xiao Yi, Daoyuan Wu, Jianliang Xu, Yingjiu Li, Debin Gao Dec 2024

Agchain: A Blockchain-Based Gateway For Trustworthy App Delegation From Mobile App Markets, Mengjie Chen, Xiao Yi, Daoyuan Wu, Jianliang Xu, Yingjiu Li, Debin Gao

Research Collection School Of Computing and Information Systems

The popularity of smartphones has led to the growth of mobile app markets, creating a need for enhanced transparency, global access, and secure downloading. This paper introduces AGChain, a blockchain-based gateway that enables trustworthy app delegation within existing markets. AGChain ensures that markets can continue providing services while users benefit from permanent, distributed, and secure app delegation. During its development, we address two key challenges: significantly reducing smart contract gas costs and enabling fully distributed IPFS-based file storage. Additionally, we tackle three system issues related to security and sustainability. We have implemented a prototype of AGChain on Ethereum and Polygon …


Editorial For The Special Issue Of The Metaverse, Fiona Fui-Hoon Nah, Gert-Jan De Vreede, Lakshmi Goel, Eric Lim, Shu Schiller, Chee-Wee Tan Dec 2024

Editorial For The Special Issue Of The Metaverse, Fiona Fui-Hoon Nah, Gert-Jan De Vreede, Lakshmi Goel, Eric Lim, Shu Schiller, Chee-Wee Tan

Research Collection School Of Computing and Information Systems

The metaverse is laying the groundwork for more accessible and immersive experiences by blending the physical and virtual worlds into a unified space where people can interact, create, and connect in entirely new ways. It holds the potential to revolutionize how we work, socialize, and learn, which in turn gives rise to unprecedented opportunities for innovation. In this special issue, we present four articles that depict the current state of research in metaverse, the key themes and theoretical underpinnings within this space, as well as emerging directions for future work. This special issue delivers valuable insights for both researchers and …


Virtual Conferencing Fatigue: Look‑Alike Avatar And Facial Attractiveness, Yuxin Liu, Keng Siau, Xueqing Wang, Yang Yang Dec 2024

Virtual Conferencing Fatigue: Look‑Alike Avatar And Facial Attractiveness, Yuxin Liu, Keng Siau, Xueqing Wang, Yang Yang

Research Collection School Of Computing and Information Systems

The rapid evolution of avatar-related technologies provides extensive opportunities for diverse avatar applications in various areas. This study aims to investigate the innovative use of avatars to mitigate virtual conferencing fatigue, which refers to the physical and mental exhaustion from the inappropriate use of virtual conferencing applications. Grounded in Self-Awareness Theory, the research compares the impact of using real faces and user-look-alike avatars on virtual conferencing fatigue, delving into its underlying factors. In addition, the study examines the role of facial attractiveness enhancement on virtual conferencing fatigue. Laboratory experiments with a 2-by-2 between-subject design are employed to test hypotheses. The …


Generating A Reflexive Ai-Assisted Workflow For Academic Writing, Corey W. Johnson, Trena M. Paulus Dec 2024

Generating A Reflexive Ai-Assisted Workflow For Academic Writing, Corey W. Johnson, Trena M. Paulus

The Qualitative Report

Digital research workflows are study designs that intentionally consider the use of technology in meaningful and reflexive ways. While most scholars use digital tools and spaces in their research process, doing so has consequences that are infrequently considered in an intentional way. Especially in this age of generative AI, technology integration into research studies will have an even greater impact and consequences on study outcomes. This paper documents one digital research workflow, the academic writing process, to demonstrate how inviting generative AI to be a writing partner can be done in a reflexive manner. Drawing on Paulus and Lester’s (2023) …


Determinants Of Child Care Subsidy Policies In The American States: A Mixed-Method Investigation In The Era Of Covid-19, Hailey Heinz Dec 2024

Determinants Of Child Care Subsidy Policies In The American States: A Mixed-Method Investigation In The Era Of Covid-19, Hailey Heinz

Political Science ETDs

This mixed-method dissertation investigates policy variation in states’ administration of the federal child care subsidy program (CCDF). The quantitative chapters draw on a 50-state, ten-year dataset to examine associations between state characteristics and CCDF policy outcomes. These analyses conclude that state-level drivers of CCDF policy are distinct from drivers identified in the cash welfare literature, and that drivers vary across dimensions of CCDF policy. The qualitative chapters report results from a comparative case study examining CCDF policy in New Mexico and Nevada from 2010 to 2022. These analyses conclude that the departmental placement of the CCDF program within state government …


A Report Summarizing Hsc Faculty Participants: Ithaka S+R Coordinated Study Making Ai Generative For Higher Education, Laura J. Hall, Robyn Gleasner Dec 2024

A Report Summarizing Hsc Faculty Participants: Ithaka S+R Coordinated Study Making Ai Generative For Higher Education, Laura J. Hall, Robyn Gleasner

Publications

This report presents findings from the University of New Mexico Health Sciences Center’s (HSC) participation in the ITHAKA S+R study Making AI Generative for Higher Education. Seven faculty members from HSC disciplines including internal medicine, pathology, psychiatry, nursing, radiology, and population health were interviewed to explore their perspectives on generative AI (GenAI) in teaching and learning, research and scholarship, and institutional support. A unique theme of “practice” emerged, reflecting how GenAI is influencing clinical care, bench-to-bedside translation, and the preparation of students for future professional practice. The report highlights faculty experiences, ethical concerns, and support needs, offering insight into how …


University ‘Pay-For-Grades’: The Bait And Switch Search Engine Optimization Strategies Of Contract Cheating Websites In The United States, Timothy M. Daly, James C. Ryan Dec 2024

University ‘Pay-For-Grades’: The Bait And Switch Search Engine Optimization Strategies Of Contract Cheating Websites In The United States, Timothy M. Daly, James C. Ryan

All Works

This paper presents the first systematic investigation into the search engine optimization practices of major contract cheating websites in the United States. From a business perspective, visibility in organic search engine results is considered one of the top client recruitment tools. The current understanding of student recruitment strategies by these companies remains largely unexplored in both academic literature and popular press. Replicating the business research practices used in the search engine optimization industry, comprehensive search engine ranking and traffic data was obtained for the 38 largest contract cheating websites in the US. The overall objective was to illuminate the strategies …


Identity And Inequality Misperceptions, Demographic Determinants And Efficacy Of Corrective Measures, K. Peren Arin, Deni Mazrekaj, Marcel Thum, Juan A. Lacomba, Francisco Lagos Dec 2024

Identity And Inequality Misperceptions, Demographic Determinants And Efficacy Of Corrective Measures, K. Peren Arin, Deni Mazrekaj, Marcel Thum, Juan A. Lacomba, Francisco Lagos

All Works

By conducting two waves of large-scale surveys in the United Kingdom and Germany, we investigate the determinants of identity and inequality misperceptions. We first show that people substantially overestimate the share of immigrants, Muslims, people under the poverty line, and the income share of the richest. Moreover, women, lower-income, and lower-educated respondents generally have higher misperceptions. Only income share misperceptions are associated more with people who place themselves on the left of the political spectrum. In contrast, the other three misperceptions are more prevalent among those who place themselves to the right. We then attempt to correct misperceptions by conducting …


Toward A Globally Lunar Calendar: A Machine Learning-Driven Approach For Crescent Moon Visibility Prediction, Samia Loucif, Murad Al-Rajab, Raed Abu Zitar, Mahmoud Rezk Dec 2024

Toward A Globally Lunar Calendar: A Machine Learning-Driven Approach For Crescent Moon Visibility Prediction, Samia Loucif, Murad Al-Rajab, Raed Abu Zitar, Mahmoud Rezk

All Works

This paper presents a comprehensive approach to harmonizing lunar calendars across different global regions, addressing the long-standing challenge of variations in new crescent Moon sightings that mark the beginning of lunar months. We propose a machine learning (ML)-based framework to predict the visibility of the new crescent Moon, representing a significant advancement toward a globally unified lunar calendar. Our study utilized a dataset covering various countries globally, making it the first to analyze all 12 lunar months over a span of 13 years. We applied a wide array of ML algorithms and techniques. These techniques included feature selection, hyperparameter tuning, …


2022 Carroll County Advisory Council Minutes And Agendas, Mikayla Cerney Dec 2024

2022 Carroll County Advisory Council Minutes And Agendas, Mikayla Cerney

UNH Cooperative Extension

No abstract provided.


Predictive Model For Listeria Monocytogenes In Rte Meats Using Exclusive Food Matrix Data, N.A. Nanje Gowda, Manjari Singh, Gijs Lommerse, Saurabh Kumar, Eelco Heintz, Jeyamkondan Subbiah Dec 2024

Predictive Model For Listeria Monocytogenes In Rte Meats Using Exclusive Food Matrix Data, N.A. Nanje Gowda, Manjari Singh, Gijs Lommerse, Saurabh Kumar, Eelco Heintz, Jeyamkondan Subbiah

Food Science Faculty Publications and Presentations

Post-processing contamination of Listeria monocytogenes has remained a major concern for the safety of ready-to-eat (RTE) meat products that are not reheated before consumption. Mathematical models are rapid and cost-effective tools to predict pathogen behavior, product shelf life, and safety. The objective of this study was to develop and validate a comprehensive model to predict the Listeria growth rate in RTE meat products as a function of temperature, pH, water activity, nitrite, acetic, lactic, and propionic acids. The Listeria growth data in RTE food matrices, including RTE beef, pork, and poultry products (731 data sets), were collected from the literature …


Using Nano-Ities For Detection Of Metal Ions In Complex Aqueous Solutions, Mohammed Muzammil Nishar Ahmed Dec 2024

Using Nano-Ities For Detection Of Metal Ions In Complex Aqueous Solutions, Mohammed Muzammil Nishar Ahmed

Theses and Dissertations

Recent urbanization has induced a rapid increase in heavy metal exposure to humans. The exploitation of heavy metals for economic gains coupled with poor and economically infeasible recycling methods have led to poor management of heavy metal wastes, which has opened up several pathways for heavy metals to enter the human body. Such heavy metals target many vital organs, but the early symptoms are common and difficult to diagnose. Severe symptoms appear in later stages and are very expensive to treat and the damage caused to the health are not typically reversable in such later stages. To counter this issue, …


Demonstrating Feasibility Of Ultrasound-Sensitive Microbubbles Delivery To Treat Disruptions In The Blood Brain Barrier Endothelium, Rubens Jourdain Dec 2024

Demonstrating Feasibility Of Ultrasound-Sensitive Microbubbles Delivery To Treat Disruptions In The Blood Brain Barrier Endothelium, Rubens Jourdain

Theses and Dissertations

Vascular cognitive impairment and dementia (VCID) is one of the main causes of dementia. VCID is caused by age and other genetic factors that lead to disruptions in the blood brain barrier (BBB) and allow blood components to enter the brain. The currently available treatments of VCID include opening the BBB with high-frequency-ultrasound to deliver drugs to the brain. However, this only treats the already developed disease. Consequently, we developed a new drug delivery system whose goal is to restore the brain capillary endothelial cells (BCEC) lining the blood vessel. The objective of this study was to demonstrate the feasibility …


Investigation Of Reproductive Inhibition During Chronic Heat Stress In C. Elegans, Macy Makenna Nielander Dec 2024

Investigation Of Reproductive Inhibition During Chronic Heat Stress In C. Elegans, Macy Makenna Nielander

Theses and Dissertations

Nearly all organisms experience heterogeneity in environmental conditions that can negatively impact fitness. A common adaptive strategy to reduce the impact of this stress is called facultative diapause, where development and reproduction are temporarily arrested to promote survival. Facultative diapause is characterized by three major criteria, the arrest must be (i) induced by an unfavorable environmental condition, (ii) reversible, and (iii) driven by genetically regulated mechanisms. The aim of this thesis was to determine whether chronic heat-induced inhibition of egg laying in Caenorhabditis elegans represents a novel form of facultative diapause. It was found that the inhibition of egg-laying is …


Addressing Ethical Issues In Healthcare Artificial Intelligence Using A Lifecycle-Informed Process, Benjamin X Collins, Jean-Christophe Bélisle-Pipon, Barbara J Evans, Kadija Ferryman, Xiaoqian Jiang, Camille Nebeker, Laurie Novak, Kirk Roberts, Martin Were, Zhijun Yin, Vardit Ravitsky, Joseph Coco, Rachele Hendricks-Sturrup, Ishan Williams, Ellen W Clayton, Bradley A Malin, Bridge2ai Ethics And Trustworthy Ai Working Group Dec 2024

Addressing Ethical Issues In Healthcare Artificial Intelligence Using A Lifecycle-Informed Process, Benjamin X Collins, Jean-Christophe Bélisle-Pipon, Barbara J Evans, Kadija Ferryman, Xiaoqian Jiang, Camille Nebeker, Laurie Novak, Kirk Roberts, Martin Were, Zhijun Yin, Vardit Ravitsky, Joseph Coco, Rachele Hendricks-Sturrup, Ishan Williams, Ellen W Clayton, Bradley A Malin, Bridge2ai Ethics And Trustworthy Ai Working Group

Faculty, Staff and Student Publications

OBJECTIVES: Artificial intelligence (AI) proceeds through an iterative and evaluative process of development, use, and refinement which may be characterized as a lifecycle. Within this context, stakeholders can vary in their interests and perceptions of the ethical issues associated with this rapidly evolving technology in ways that can fail to identify and avert adverse outcomes. Identifying issues throughout the AI lifecycle in a systematic manner can facilitate better-informed ethical deliberation.

MATERIALS AND METHODS: We analyzed existing lifecycles from within the current literature for ethical issues of AI in healthcare to identify themes, which we relied upon to create a lifecycle …


The Role Of Porphyromonas Gingivalis In Inducing Il-6 Macrophages Expression In Ovaries Of Periodontitis Models, Agustin Ws. Dharmayanti, Ernie M. Setiawatie, Hendy Hendarto Dec 2024

The Role Of Porphyromonas Gingivalis In Inducing Il-6 Macrophages Expression In Ovaries Of Periodontitis Models, Agustin Ws. Dharmayanti, Ernie M. Setiawatie, Hendy Hendarto

Journal of Dentomaxillofacial Science

Objective: This study aimed to determine whether P. gingivalis induction in the gingival sulcus increased IL-6 expression by macrophages in the ovaries.

Material and Methods: This research was a laboratory experiment using a post-test-only control group design, using female white rats strain Sprague Dawley, six weeks old and in the estrous phase. They were divided into the control and treatment groups. The animal models were induced with P. gingivalis in the mesial gingival sulcus of their first right and left lower jaw molars, with 0.05 ml every three days for 19 days. On 0, 7, 14 days after bacteria induction, …


Integration Of Blockchain Technology In Industrial Applications, Sanjana Sakinala Dec 2024

Integration Of Blockchain Technology In Industrial Applications, Sanjana Sakinala

Theses

This research explores the integration of Hyperledger Fabric., a framework of blockchain in industrial applications, particularly focusing on supply chain management. By addressing the limitations of traditional blockchains - such as high transaction latency, scalability challenges, and privacy concerns - this research demonstrates how Hyperledger fabrics overcomes them. Through simulation, we show significant enhancements in transaction speed, data privacy and scalability, making the Fabric a viable solution for industrial systems.


Targeting The Glutamine-Arginine-Proline Metabolism Axis In Cancer, Di Wang, Jiang-Jie Duan, Yu-Feng Guo, Jun-Jie Chen, Tian-Qing Chen, Jun Wang, Shi-Cang Yu Dec 2024

Targeting The Glutamine-Arginine-Proline Metabolism Axis In Cancer, Di Wang, Jiang-Jie Duan, Yu-Feng Guo, Jun-Jie Chen, Tian-Qing Chen, Jun Wang, Shi-Cang Yu

Faculty, Staff and Student Publications

Metabolic abnormalities are an important feature of tumours. The glutamine-arginine-proline axis is an important node of cancer metabolism and plays a major role in amino acid metabolism. This axis also acts as a scaffold for the synthesis of other nonessential amino acids and essential metabolites. In this paper, we briefly review (1) the glutamine addiction exhibited by tumour cells with accelerated glutamine transport and metabolism; (2) the methods regulating extracellular glutamine entry, intracellular glutamine synthesis and the fate of intracellular glutamine; (3) the glutamine, proline and arginine metabolic pathways and their interaction; and (4) the research progress in tumour therapy …


Take A Ballot: Can Transnational Theatre Foster Political Efficacy In Women Of Color?, Breanna Marie Bailey Dec 2024

Take A Ballot: Can Transnational Theatre Foster Political Efficacy In Women Of Color?, Breanna Marie Bailey

Undergraduate Honors Theses

This research examines whether transnational theatre fosters political efficacy in women of color. Research shows the history of disenfranchisement of women of color; even today, upper-class, white males have the greatest access to civic resources– including access to theatre–which ignite their political efficacy in the United States. The gap in research surrounds how, and if, transnational theatre can affect women of color’s political efficacy. By analyzing theatre’s role in engaging political efficacy, I offer an avenue to build a more equitable and democratic society. Using a case study analysis of two female playwrights from opposite sides of the U.S. border–Sor …


Preparing Educators To Effectively Engage With Postsecondary Stem Students With Autism, Luzconsuelo Gavaldon Dec 2024

Preparing Educators To Effectively Engage With Postsecondary Stem Students With Autism, Luzconsuelo Gavaldon

Open Access Theses & Dissertations

Autism spectrum disorder (ASD) is a lifetime mental disability (Boucher, 2009). Because the brains of people with autism work differently than their non-neurodiverse peers (Kuzminskaite et al., 2020), they tend to respond to external stimuli in a hypo- or hyper-sensory fashion. One of the primary considerations that must be accounted for when working with individuals with autism is that the brains of these persons are each neurologically distinct. In other words, there is no "one-size-fits-all" means by which individuals with ASD learn and develop and, consequently, no single way to therefore engage with said individuals (Anderson & Butt, 2017; Kuzminski …


Myofibroblast Targeted Liposomes For The Treatment Of Skin Fibrosis, Elfa Beaven Dec 2024

Myofibroblast Targeted Liposomes For The Treatment Of Skin Fibrosis, Elfa Beaven

Open Access Theses & Dissertations

Continuous overactivation of myofibroblasts leads to excessive deposition of profibrotic proteins, which in turn causes tissue stiffness and, ultimately, organ failure. One of those proteins, Cadherin-11 (CDH11), is reported to be overexpressed in the tissue of fibrotic skin, specifically on myofibroblasts. Similarly, chronic inflammation drives fibrosis progression in autoimmune-related illnesses like systemic sclerosis (SSc). Therefore, it is hypothesized that CDH11 could be a target for cell-specific delivery of antifibrotic therapies to fibrotic skin tissue. Here, a CDH11 peptide conjugated liposome loaded with Tofacitinib, a JAK inhibitor, was developed to understand the potential of targeted therapies to treat skin fibrosis. The …


Not Plato's Closet: The Dialectic Of Embodied Counterstory Through Fashion On The Us/Mexico Border, Brita M. Arrington Dec 2024

Not Plato's Closet: The Dialectic Of Embodied Counterstory Through Fashion On The Us/Mexico Border, Brita M. Arrington

Open Access Theses & Dissertations

This dissertation is best understood as a journey about identity that took place over more than eight years. The journey was an exploration that began in one frame of mind and ended in a very different place. I fully anticipated this research to reflect the racial tensions surrounding my participants who are predominantly Latine students at UTEP, a "Hispanic serving" institution on the US/Mexico border, but we ended up a place more deeply personal to them. From a sample of 2000 FYC students and their instructors, 65 participants engaged in taking a survey about their dress practices, and 4 of …