Digital Commons Network^™

Multicentric Assessment Of A Multimorbidity-Adjusted Disability Score To Stratify Depression-Related Risks Using Temporal Disease Maps: Instrument Validation Study, Rubèn González-Colom, Kangkana Mitra, Emili Vela, Andras Gezsi, Teemu Paajanen, Zsófia Gál, Gabor Hullam, Hannu Mäkinen, Tamas Nagy, Mikko Kuokkanen

School of Medicine Publications

Background: Comprehensive management of multimorbidity can significantly benefit from advanced health risk assessment tools that facilitate value-based interventions, allowing for the assessment and prediction of disease progression. Our study proposes a novel methodology, the Multimorbidity-Adjusted Disability Score (MADS), which integrates disease trajectory methodologies with advanced techniques for assessing interdependencies among concurrent diseases. This approach is designed to better assess the clinical burden of clusters of interrelated diseases and enhance our ability to anticipate disease progression, thereby potentially informing targeted preventive care interventions.

Objective: This study aims to evaluate the effectiveness of the MADS in stratifying patients into clinically relevant risk …

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Executive Actions

No abstract provided.

Crystal Structure Of Trichinella Spiralis Calreticulin And The Structural Basis Of Its Complement Evasion Mechanism Involving C1q, Zhihui Jia, Wen Yu, Jingmo Li, Mingming Zhang, Bin Zhan, Liming Yan, Zhenhua Ming, Yuli Cheng, Xiaolin Tian, Shuai Shao, Jingjing Huang, Xinping Zhu

Faculty, Staff and Students Publications

Helminths produce calreticulin (CRT) to immunomodulate the host immune system as a survival strategy. However, the structure of helminth-derived CRT and the structural basis of the immune evasion process remains unclarified. Previous study found that the tissue-dwelling helminth Trichinella spiralis produces calreticulin (TsCRT), which binds C1q to inhibit activation of the complement classical pathway. Here, we used x-ray crystallography to resolve the structure of truncated TsCRT (TsCRTΔ), the first structure of helminth-derived CRT. TsCRTΔ was observed to share the same binding region on C1q with IgG based on the structure and molecular docking, which explains the inhibitory effect of TsCRT …

Changes In Patterns Of Referral For Inpatient Rehabilitation Cancer Patients Due To Covid-19: A Retrospective Study, Ekta Gupta, Amy H Ng, Aline Rozman De Moraes, Jack B Fu, Jegy M Tennison, Maaheen Ahmed, Bryan M Fellman, Eduardo Bruera

Faculty, Staff and Students Publications

There is a paucity of literature on the effect of COVID-19 on hospital processes. We hypothesized that COVID-19 was associated with decreased cancer physiatry referrals in 2020. This is a retrospective cohort study of consecutive patients from April to July 2019 and 2020 admitted at an academic quaternary cancer center. The main outcomes were number of hospital admissions, rate, and characteristics of inpatient rehabilitation admissions and change in percentage of physiatry referrals as the primary endpoint. Results showed that in 2019, there were 387 referrals from 10,274 inpatient admissions (3.8%; 95% confidence interval, 2.4-4.2), compared with 337 referrals from 7051 …

Health, Salud, : Individualizing Behavioral Needs In A Multicultural World, Madeline Rock, Dustan Watkins, Elizabeth M Vaughan, Craig A Johnston

Faculty, Staff and Students Publications

Diversity within the United States continues to increase, making it imperative that health care providers understand the impact of cultural background on health behaviors and perceptions. These practices promote trusting patient-provider relationships, improve outcomes, and increase patient satisfaction. In this article, we discuss the 3 largest ethnic or racial minority groups in the United States, Hispanics, African Americans, and Asians, and the intersection of culture and health care through the lens of these distinct communities. We also offer behavioral recommendations to increase awareness and knowledge regarding vast cultural variations within our communities while embracing cultural humility.

A Review Of Current Safe Distance Calculations And The Risk Of Mild Traumatic Brain Injury, A. R. Loflin, C. E. Johnson

Mining Engineering Faculty Research & Creative Works

Explosive breaching is a tactic operational professionals use to gain rapid entry and tactical advantage. This tactic exposes individuals to repeated low-level blasts (LLB), overpressure exposure generally occurring from user-directed munitions. The experimentation described in this paper highlights the need for further research into implementing explosives in tactical situations, specifically in confined areas, and the effects on individuals exposed. While current safety calculations predict peak pressures from an open-air detonation, this study incorporates the impulse of the total explosive event in a confined space. Sixteen explosive events were conducted to measure peak overpressures of the total duration of the event …

The Mechanism And Effect Of Seismic Source Location Using Double Waves In Three-Dimensional Microseismic Monitoring, Zhigang Wang, Xiaoqing Wang, Shunlin Yin, Maochen Ge

Mining Engineering Faculty Research & Creative Works

Accurate seismic source location has always been the most important purpose of micro seismic and seismic monitoring. The location accuracy inside the existing monitoring networks is generally high, whereas the accuracy in the external area and sensor accessories area tends to be low. This scenario contributes to an overall limitation in the effective monitoring area. The seismic source location was performed in this study using P waves and S waves to improve the location accuracy outside the monitoring networks and in the adjacent area and enlarge the high-accuracy control area of the monitoring networks. Moreover, the mechanism of seismic source …

Spatiotemporal Variance Image Reconstruction For Thermographic Inspections, Logan M. Wilcox, Emily M. Johnson, Emma T. Bohannon, Catherine E. Johnson, Kristen M. Donnell

Mining Engineering Faculty Research & Creative Works

Active microwave thermography (AMT) is a nondestructive testing and evaluation (NDT&E) technique that utilizes a radiating antenna to induce a thermal increase on or within a specimen under test (SUT). The radiated power density is spatially nonuniform and therefore results in a spatially nonuniform thermal excitation, which may result in missed or false indications of defects. To this end, this work proposes a novel image reconstruction technique for nonuniform excitation/heating and is referred to as Spatiotemporal Variance Reconstruction (STVR). STVR utilizes the spatial and temporal variance of the surface thermal profile. STVR is advantageous in that it does not require …

Designing Equitable Media Literacy Interventions For Critical Youth Agency, Bobbie Foster, Paul Mihailidis, Patrick R. Johnson, Shannon Burth, Melissa Tully, Srividya Ramasubramanian, Emily Riewestahl

College of Communication Faculty Research and Publications

In recent years, young people engaged in political discourse and civic action online. U.S.-based social movements centered on equity issues, such as Black Lives Matter, Dreamers, and March for Our Lives, engaged young people in shaping and publicizing the goals of these movements through digital platforms. Increasingly in communities at the margins, young Americans need digital and media literacy skills to supplement contentious education restrictions within the United States, as with many state bills curtailing the teaching of LGBTQIA+ histories and critical race theory. With these considerations in mind, our team conducted a national study of impactful media literacy in …

Mitigating Organizational Conspiracy Beliefs Through Strategic Internal Communication And Employee–Organization Relationships (Eor) In The Workplace, Young Kim, Hyunji (Dana) Lim

College of Communication Faculty Research and Publications

The purpose of this study is to explore how strategic internal communication and the quality of employee – organization relationship (EOR) can reduce organizational conspiracy beliefs among employees and thus prevent the negative outcomes thereof in the workplace. Using a national survey (N = 810) of full-time employees in the United States, this study found that high-quality EOR based on two-way symmetrical communication with employees is likely to reduce the potential for conspiracy theories and, in turn, for turnover intentions in the workplace. This finding provides meaningful insight into how internal communication managers can mitigate negative employee outcomes that …

The Influence Of Surfactants' Ionicity On The Performance Of Coal Dust Suppression, Zidong Zhao, Ping Chang, Apurna Ghosh, Guang Xu, Yanwei Liu, Ramakrishna Morla

Mining Engineering Faculty Research & Creative Works

Coal dust is a significant health hazard for coal workers, as prolonged inhalation can lead to severe diseases such as Coal Workers' Pneumoconiosis. Water spray with surfactants is commonly used as a pre-control strategy to control coal dust in underground mines. The zeta potential test is a widely used static test to evaluate surfactants with different ionicities. However, there are still some arguments about the evaluation criteria of zeta potential on surfactant performance between different researchers. Moreover, whether zeta potential can be used as an index to evaluate the surfactant suppression performance is inconclusive. To address these problems, this study …

Necessity Entrepreneurship: An Examination Of Control Beliefs, Suwakitti Amornpan, Leon Schjoedt, Krittaya Sangboon

Marketing Faculty Publications

In the context of necessity entrepreneurship, control beliefs (that is, entrepreneurial locus of control and entrepreneurial self-efficacy) are examined as individual moderators and as simultaneous moderators of the effect perceived economic uncertainty has on entrepreneurial intention. Using recognized measures and an online questionnaire, data from a sample of 285 undergraduate business students are used to test a series of hypotheses. While confirming past findings, the results also provide surprising findings. The findings provide potential explanations for why previous research varies regarding locus of control, while the results are consistent with past entrepreneurship research on self-efficacy. Importantly, the results show that …

Numerical Investigation For The Effect Of Joint Persistence On Rock Slope Stability Using A Lattice Spring-Based Synthetic Rock Mass Model, Mariam Al-E'Bayat, Dogukan Guner, Taghi Sherizadeh, Mostafa Asadizadeh

Mining Engineering Faculty Research & Creative Works

This study underscores the profound influence of rock joints, both persistent and non-persistent with rock bridges, on the stability and behavior of rock masses—a critical consideration for sustainable engineering and natural structures, especially in rock slope stability. Leveraging the lattice spring-based synthetic rock mass (LS-SRM) modeling approach, this research aims to understand the impact of persistent and non-persistent joint parameters on rock slope stability. The Slope Model, a Synthetic Rock Mass (SRM) approach-based code, is used to investigate the joint parameters such as dip angle, spacing, rock bridge length, and trace overlapping. The results show that the mobilizing zones in …

Comparative Analysis Of Different Cfd Turbulence Models For A Diesel Pool Combustion Event In An Underground Mine: A Case Study, Ashish Ranjan Kumar, Oluwafemi Salami, Nana A. Amoah, Guang Xu

Mining Engineering Faculty Research & Creative Works

Underground Mine Fires Are Dangerous, Consume Resources, and Emit Pollutants. Therefore, Acquiring In-Mine Data for Fire Research is Hazardous and Expensive Due to Unsteady Temperature Changes and Toxic Gas Emissions. Computational Fluid Dynamics (CFD) Models Are Often Developed to Mimic Airflows and Combustion-Associated Heat Transfer. However, Research on the Performance Evaluation of the CFD Turbulence Models to Mimic Fire Events is Limited. This Paper Summarises the Modelling Results for a Diesel Pool Fire Event in an Experimental Underground Mine that Uses an Exhaust Ventilation System. a Fire Dynamics Simulator (FDS) Model Was Developed to Show the Spatio-Temporal Temperature Evolution. Reynolds-Averaged …

Investigation Into Helmet–Head Shock Wave Interactions At Low Overpressures Through Free-Field Blasts And Schlieren Imagery, C. J.H. Thomas, Catherine E. Johnson

Mining Engineering Faculty Research & Creative Works

Brain Injuries in Warfighters Due to Low-Level Blasts, Even While Wearing a Helmet, Are Common. Understanding How the Form of a Shock Wave Changes When Impacting a Head Donning a Helmet May Present Solutions to Reducing Shock Loading on the Head, Thereby Reducing the Prevalence of Blast-Induced Traumatic Brain Injury. a Manikin with PCB Piezoelectric Transducers throughout the Head Was Exposed to Low-Pressure Free-Field Blasts using an RDX-Based Explosive Charge Designed to Output a Side-On overpressure of 4 Pounds Per Square Inch (Psi) [27.5 Kilopascals (KPa)] with and Without a Helmet. Orientations of 0, 45, 90, 135, and 180 Degrees …

Quantitative Proteomic Profiling In Brain Subregions Of Mice Exposed To Open-Field Low-Intensity Blast Reveals Position-Dependent Blast Effects, M. Jackson, S. Chen, P. Liu, M. Langenderfer, C. Li, H. R. Siedhoff, A. Balderrama, R. Li, Catherine E. Johnson, C. M. Greenlief, I. Cernak, R. G. Depalma, J. Cui

Mining Engineering Faculty Research & Creative Works

The Neurological Consequences of Combat Blast-Induced Neurotrauma (BINT) Pose Important Clinical Concerns for Military Service Members and Veterans. Previous Studies Have Shown that Low-Intensity Blast (LIB) Results in BINT with Multifaceted Characteristics in Mice Exposed to Open-Field Blast in Prone Position. Although the Prone Position is Natural for Rodents, Experimental Models of Blast using This Position Do Not Represent Common Scenarios of Human Standing While Being Exposed to Blast during Deployment or Military Training. in This Study, We Used Our Previously Developed BINT Mouse Model of Open-Field LIB with Mice in an Upright Position and Then Used Quantitative Proteomics and …

Twenty Years Of Epithelial-Mesenchymal Transition: A State Of The Field From Temtia X, Pierre Savagner, Thomas Brabletz, Chonghui Cheng, Christine Gilles, Tian Hong, Myriam Polette, Guojun Sheng, Marc P Stemmler, Erik W Thompson

Faculty, Staff and Students Publications

This report summarizes the 10th biennial meeting of The Epithelial Mesenchymal Transition International Association (TEMTIA), that took place in Paris on November 7-10, 2022. It provides a short but comprehensive introduction to the presentations and discussions that took place during the 3-day meeting. Similarly to previous TEMTIA meetings, TEMTIA X reviewed the most recent aspects of the epithelial-mesenchymal transition (EMT), a cellular process involved during distinct stages of development but also during wound healing and fibrosis to some degree. EMT has also been associated at various levels during tumor cell progression and metastasis. The meeting emphasized the intermediate stages of …

Immunohistochemical Analysis Of Dentigerous Cysts And Odontogenic Keratocysts Associated With Impacted Third Molars—A Systematic Review, Luis Eduardo Almeida, David Lloyd, Daniel Boettcher, Olivia Kraft, Samuel Zammuto

School of Dentistry Faculty Research and Publications

Objective: This systematic review investigates the diagnostic, prognostic, and therapeutic implications of immunohistochemical markers in dentigerous cysts (DCs) and odontogenic keratocysts (OKCs) associated with impacted third molars.

Materials and Methods: A comprehensive search strategy was employed across major databases including MEDLINE/PubMed, EMBASE, and Web of Science, from the inception of the databases to March 2024. Keywords and Medical Subject Heading (MeSH) terms such as “dentigerous cysts”, “odontogenic keratocysts”, “immunohistochemistry”, “Ki-67”, and “p53” were used. The PRISMA 2020 guidelines were followed to ensure methodological rigor. Inclusion criteria encompassed studies on humans and animals providing definitive diagnoses or specific signs and symptoms …

Evaluating Surgical Approaches For Hemimandibular Hyperplasia Associated With Osteochondroma: A Systematic Literature Review, Luis Eduardo Almeida, Samuel Zammuto, Diego Fernando Lopez

School of Dentistry Faculty Research and Publications

Background/Objectives: Hemimandibular hyperplasia (HH) associated with osteochondroma presents complex challenges in maxillofacial surgery, including facial asymmetry, occlusal instability, and temporomandibular joint (TMJ) dysfunction. Surgical interventions vary widely in approach and outcomes, underscoring the need for a systematic evaluation of effectiveness. This systematic review assesses the effectiveness of surgical approaches for managing HH associated with osteochondroma, focusing on techniques including condylectomy, orthognathic surgery, distraction osteogenesis, total joint replacement (TJR), and genioplasty. Methods: Following PRISMA 2020 guidelines, a comprehensive search was conducted in PubMed, Scopus, and Web of Science for studies published from 2000 to 2023. Eligibility criteria were based on the …

Bayesian Rare Variant Analysis Identifies Novel Schizophrenia Putative Risk Genes, Shengtong Han

School of Dentistry Faculty Research and Publications

The genetics of schizophrenia is so complex that it involves both common variants and rare variants. Rare variant association studies of schizophrenia are challenging because statistical methods for rare variant analysis are under-powered due to the rarity of rare variants. The recent Schizophrenia Exome meta-analysis (SCHEMA) consortium, the largest consortium in this field to date, has successfully identified 10 schizophrenia risk genes from ultra-rare variants by burden test, while more risk genes remain to be discovered by more powerful rare variant association test methods. In this study, we use a recently developed Bayesian rare variant association method that is powerful …

Association Between Periodontal Health Status And Quality Of Life: A Cross-Sectional Study, Kinan M. Al-Bitar, Jeffery M. Garcia, Shengtong Han, Arndt Guentsch

School of Dentistry Faculty Research and Publications

Introduction: Attachment loss due to periodontal diseases is associated with functional limitations as well as physical pain and psychological discomfort, which may lead to a reduced quality of life. The purpose of this study is to determine if the oral health status, specifically the periodontal status, influences oral health–related quality of life.

Materials and methods: Survey data were collected in a US dental school clinical setting in a cross-sectional study. Quality of life related to oral health was assessed with the Oral Health Impact Profile-49 (OHIP-49). In addition, DMFT index, periodontal status, and health literacy scores (dental and medical health …

Becoming A Good Creature (2020) By Sy Montgomery, Samantha Piede

Picture Books

Becoming a Good Creature outlines moral lessons Sy Montgomery has learned from interactions with animals, both domestic and wild, such as “Love Little Lives,” “Don’t Be Afraid,” and “Make Your Own Family.” Our willingness to be attentive to other creatures – not just the ones like us with “two legs,” but also “four or even eight” – opens up the possibility of finding something ethically significant in these encounters. She tells us that “all have taught me something important about how to be a good creature in the world.”

Structure And Funding Of Clinical Informatics Fellowships: A National Survey Of Program Directors, Tushar N Patel, Aaron J Chaise, John J Hanna, Kunal P Patel, Karl M Kochendorfer, Richard J Medford, Dara E Mize, Edward R Melnick, Jonathan D Hron, Kenneth Youens, Deepti Pandita, Michael G Leu, Gregory A Ator, Feliciano Yu, Nicholas Genes, Carrie K Baker, Douglas S Bell, Joshua M Pevnick, Steven A Conrad, Aarti R Chandawarkar, Kendall M Rogers, David C Kaelber, Ila R Singh, Bruce P Levy, John T Finnell, Joseph Kannry, Natalie M Pageler, Vishnu Mohan, Christoph U Lehmann

Faculty, Staff and Students Publications

BACKGROUND: In 2011, the American Board of Medical Specialties established clinical informatics (CI) as a subspecialty in medicine, jointly administered by the American Board of Pathology and the American Board of Preventive Medicine. Subsequently, many institutions created CI fellowship training programs to meet the growing need for informaticists. Although many programs share similar features, there is considerable variation in program funding and administrative structures.

OBJECTIVES: The aim of our study was to characterize CI fellowship program features, including governance structures, funding sources, and expenses.

METHODS: We created a cross-sectional online REDCap survey with 44 items requesting information on program administration, …

Wall Motion Assessment By Feature Tracking In Pediatric Patients With Coronary Anomalies Undergoing Dobutamine Stress Cmr, Shagun Sachdeva, Silvana Molossi, Dana Reaves-O'Neal, Prakash Masand, Tam T Doan

Faculty, Staff and Students Publications

BACKGROUND: Left ventricular (LV) wall motion assessment is an important adjunct in addition to perfusion defects in assessing ischemic changes. This study aims to investigate the feasibility and utility of performing feature tracking (FT) in pediatric patients with coronary anomalies undergoing dobutamine stress CMR to assess wall motion abnormalities (WMA) and perfusion defects.

METHOD: This is a retrospective study where 10 patients with an inducible first-pass perfusion (FPP) defect and 10 without were selected. Global LV circumferential strain/strain rate (GCS/GCSR) was measured at rest and at peak stress (systole and diastole) using a commercially available feature tracking software. Peak GCS …

Long-Term Efficacy And Safety Of Cardiac Genome Editing For Catecholaminergic Polymorphic Ventricular Tachycardia, Oliver M Moore, Yuriana Aguilar-Sanchez, Satadru K Lahiri, Mohit M Hulsurkar, J Alberto Navarro-Garcia, Tarah A Word, Joshua A Keefe, Dean Barazi, Elda M Munivez, Charles T Moore, Vaidya Parthasarathy, Jaysón Davidson, William R Lagor, So Hyun Park, Gang Bao, Christina Y Miyake, Xander H T Wehrens

Faculty, Staff and Students Publications

INTRODUCTION: Heterozygous autosomal-dominant single nucleotide variants in RYR2 account for 60% of cases of catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited arrhythmia disorder associated with high mortality rates. CRISPR/Cas9-mediated genome editing is a promising therapeutic approach that can permanently cure the disease by removing the mutant RYR2 allele. However, the safety and long-term efficacy of this strategy have not been established in a relevant disease model.

AIM: The purpose of this study was to assess whether adeno-associated virus type-9 (AAV9)-mediated somatic genome editing could prevent ventricular arrhythmias by removal of the mutant allele in mice that are heterozygous for

METHODS …

Diagnostic Value Of Soluble Urokinase-Type Plasminogen Activator Receptor In Patients With Acute Coronary Syndrome: A Systematic Review And Meta-Analysis, Michal Pruc, Iwona Jannasz, Damian Swieczkowski, Grzegorz Procyk, Aleksandra Gasecka, Zubaid Rafique, Francesco Chirico, Nicola Luigi Bragazzi, Milosz J Jaguszewski, Jaroslaw Wysocki, Lukasz Szarpak

Faculty, Staff and Students Publications

BACKGROUND: In contemporary clinical practice, there is an increasing need for new clinically relevant biomarkers potentially optimizing management strategies in patients with suspected acute coronary syndrome (ACS). This study aimed to determine the diagnostic utility of soluble urokinase-type plasminogen activator receptor (suPAR) levels in individuals with suspected ACS.

METHODS: A literature search was performed in Web of Science, PubMed, Scopus, and the Cochrane Central Register of Controlled Trials databases, for studies comparing suPAR levels among patients with and without ACS groups. The methodological quality of the included papers was assessed using the Newcastle-Ottawa Scale (NOS). A fixed-effects model was used …

Treatment Of High- And Intermediate-High-Risk Pulmonary Embolism By The Pulmonary Embolism Response Team: Focus On Catheter-Directed Therapies, Arkadiusz Pietrasik, Paweł Kurzyna, Piotr Szwed, Karolina Jasińska-Gniadzik, Aleksandra Gąsecka, Szymona Darocha, Dariusz Zieliński, Łukasz Szarpak, Janusz Kochman, Marcin Grabowski, Grzegorz Opolski, Adam Torbicki, Marcin Kurzyna

Faculty, Staff and Students Publications

BACKGROUND: Multidisciplinary Pulmonary Embolism Response Teams (PERTs) were established to individualize the treatment of high-risk (HR) and intermediate-high-risk (IHR) pulmonary embolism (PE) patients, which pose a challenge in clinical practice.

METHODS: We retrospectively collected the data of all HR and IHR acute PE patients consulted by PERT CELZAT between September 2017 and October 2022. The patient population was divided into four different treatment methods: anticoagulation alone (AC), systemic thrombolysis (ST), surgical embolectomy (SE), and catheter-directed therapies (CDTx). Baseline clinical characteristics, risk stratification, PE severity parameters, and treatment outcomes were compared between the four groups.

RESULTS: Of the 110 patients with …

Meta-Analysis Of Postoperative Myocardial Injury As A Predictor Of Mortality After Living Donor Liver Transplantation, Krzysztof Jankowski, Frank W Peacock, Michal Pruc, Teresa Malecka-Massalska, Lukasz Szarpak

Faculty, Staff and Students Publications

BACKGROUND: The purpose of this study was to perform a systematic review and meta-analysis to investigate postoperative myocardial injury, as expressed by the postoperative concentration of high-sensitivity cardiac troponin I (hs-cTnI) as a predictor of mortality among living donor liver transplantation (LDLT) patients.

METHODS: PubMed, Scopus, Embase and the Cochrane Library were searched through to September 1st 2022. The primary endpoint included in-hospital mortality. Secondary endpoints were 1-year mortality and re-transplantation occurrence. Estimates are expressed as risk ratios (RRs) and 95% confidence intervals (95% CIs). Heterogeneity was assessed with the I² test.

RESULTS: During the search, 2 studies were found …

Should Targeted Temperature Management Be Used In Cardiogenic Shock Patients? Systematic Review And Meta-Analysis, Adam Nieborek, Jerzy R Ladny, Milosz J Jaguszewski, Andrea Denegri, Aleksandra Sikora, Szymon Pucylo, Aleksandra Gasecka, Michal Pruc, Ivan Savytsky, Lukasz Szarpak

Faculty, Staff and Students Publications

BACKGROUND: Therapeutic hypothermia, or targeted temperature management (TTM), is a strategy of reducing the core body temperature of survivors of sudden cardiac arrest, cardiogenic shock (CS) or stroke. Therefore, a systematic literature review and meta-analysis were performed to tackle the question about whether the implementation of TTM is actually beneficial for patients with CS.

METHODS: Study was designed as a systematic review and meta-analysis. PubMed, Cochrane Library, Web of Science and Scopus were searched from these databases inception to July 17, 2022. Eligible studies were those comparing TTM and non-TTM treatment in CS patients. Data were pooled with the Mantel-Haenszel …

The Uterine Secretome Initiates Growth Of Gynecologic Tissues In Ectopic Locations, Jan Sunde, Morgan Wasickanin, Tiffany A Katz, Laurel Gillette, Sanam Bidadi, Derek O'Neil, Ramya Masand, Richard O Burney, Kathleen A Pennington

Faculty, Staff and Students Publications

Endosalpingiosis (ES) and endometriosis (EM) refer to the growth of tubal and endometrial epithelium respectively, outside of their site of origin. We hypothesize that uterine secretome factors drive ectopic growth. To test this, we developed a mouse model of ES and EM using tdTomato (tdT) transgenic fluorescent mice as donors. To block implantation factors, progesterone knockout (PKO) tdT mice were created. Fluorescent lesions were present after oviduct implantation with and without WT endometrium. Implantation was increased (p<0.05) when tdt oviductal tissue was implanted with endometrium compared to oviductal tissue alone. Implantation was reduced (p<0.0005) in animals implanted with minced tdT oviductal tissue with PKO tdT endometrium compared to WT endometrium. Finally, oviductal tissues was incubated with and without a known implantation factor, leukemia inhibitory factor (LIF) prior to and during implantation. LIF promoted lesion implantation. In conclusion, endometrial derived implantation factors, such as LIF, are necessary to initiate ectopic tissue growth. We have developed an animal model of ectopic growth of gynecologic tissues in a WT mouse which will potentially allow for development of new prevention and treatment modalities.