Digital Commons Network^™

Do Duckweeds Adapt To Water And Microbes?, Ava M. Rose

Honors Theses and Capstones

Organisms in their home environment sometimes outperform transplanted individuals native to other areas, in a phenomenon termed local adaptation. While local adaptation is traditionally considered to be driven by the abiotic factors of an environment, scientists have recently increased consideration of biotic factors. Specifically, of interest to many is host-associated microbiomes, which can alter host trait expression. As the desire to commercialize microbiome treatments for agriculture and medicine grows, it is important to analyze the potential value of local microbiomes, which may be adapted to their hosts, or to which local hosts may have adapted. Using Lemna minor (duckweed) as …

A New Industry For Student- Athletes: An Analysis Of Nil Implications On Well-Being And Team Dynamics, Jamison W. White

Honors Theses and Capstones

As of June 2021, college athletes are allowed to benefit from selling their name, image, and likeness (NIL) by engaging in contracts with sponsors and businesses. Even though this law was passed to allow athletes to earn a fair pay for their hard work though utilizing their popularity and engaging with fans, its potential effect on athletes remains uncertain. This research examines the effects of NIL agreements on student-athletes’ well-being and team perceptions. More specifically, does the adoption of NIL place additional stress on student- athletes or disrupt their team dynamics? If so, what support can be granted to allow …

The Lighthouse Keepers Daughter: The Life And Work Of Celia Laighton Thaxter, Haley J. Parker

Honors Theses and Capstones

Living on the edge of the American empire, Celia Thaxter explored the dimensions of her life in ways that transcended, yet never fully abandoned traditional gender boundaries by cultivating her lifelong relationship with nature through creative expression. The lighthouse keeper's daughter constructed her identity based on the experiences that shaped her on the very edge of civilization. Coming of age on the Isles of Shoals, Celia reveled in flexibility and unrestricted freedom of her natural environment isolated from the cultural spheres on the mainland that reinforced the ideology of domestic femininity. This ideology was dominant in the 19th century in …

State Sovereign Immunity And The New Purposivism, Anthony J. Bellia Jr., Bradford R. Clark

Journal Articles

Since the Constitution was first proposed, courts and commentators have debated the extent to which it alienated the States’ preexisting sovereign immunity from suit by individuals. During the ratification period, these debates focused on the language of the citizen-state diversity provisions of Article III. After the Supreme Court read these provisions to abrogate state sovereign immunity in Chisholm v. Georgia, Congress and the States adopted the Eleventh Amendment to prohibit this construction. The Court subsequently ruled that States enjoy sovereign immunity independent of the Eleventh Amendment, which neither conferred nor diminished it. In the late twentieth-century, Congress began enacting statutes …

St. John Henry Newman's Development Of Doctrine And Law: Some Preliminary Notes And Questions, Jeffrey A. Pojanowski

Journal Articles

This essay, presented at a conference at the Catholic University of America's Columbus School of Law, considers how Newman's theory of development of church doctrine can illuminate the development of human law. The argument, which focuses primarily on constitutional law and tradition, identifies promising parallels but also offers cautionary notes about straightforward analogies between the two bodies of doctrine.

Assembling Hyperpop: Genre Formation On Wikipedia, Eliot Bates, Sophie Delphis, Romulo Moraes, Julia Santoli

Publications and Research

In this article, we analyze how a music genre is reciprocally defined online, through the crowdsourced ‘facts’ of Wikipedia. What are the traditional implicit and explicit exclusionary practices in this sort of genre formation? And how can internet-specific sociabilities create new exclusionary practices in the process of defining music? By analyzing the edit history of Wikipedia’s ‘hyperpop’ page, we locate ongoing debates, controversies, and contestations that point to shaping forces around online genre formation. These potentially have a huge impact on how hyperpop is understood both inside and outside of the music community. In locating the most active editors of …

Actionpoint: An App To Combat Cyberbullying Via The Strengthening Of Parent-Teen Relationships, Maddie Juarez, Natali Barragan, Deborah Hall, George K. Thiruvathukal, Yasin N. Silva

Computer Science: Faculty Publications and Other Works

Due to the increased prevalence of cyberbullying and the detrimental impact it can have on adolescents, there is a critical need for tools to help combat cyberbullying. This paper introduces the ActionPoint app, a mobile application based on empirical work highlighting the importance of strong parent-teen relationships for reducing cyberbullying risk. The app is designed to help families improve their communication skills, set healthy boundaries for social media use, identify instances of cyberbullying and cyberbullying risk, and, ultimately, decrease the negative outcomes associated with cyberbullying. The app guides parents and teens through a series of interactive modules that engage them …

Intermittent Theta Burst Stimulation And Functional Connectivity In People Living With Hiv/Aids Who Smoke Tobacco Cigarettes: A Preliminary Pilot Study, Gopalkumar Rakesh, Thomas G Adams, Rajendra A Morey, Joseph L Alcorn, Rebika Khanal, Amanda E Su, Seth S Himelhoch, Craig R Rush

Faculty, Staff and Student Publications

BACKGROUND: People living with HIV (PLWHA) smoke at three times the rate of the general population and respond poorly to cessation strategies. Previous studies examined repetitive transcranial magnetic stimulation (rTMS) over left dorsolateral prefrontal cortex (L. dlPFC) to reduce craving, but no studies have explored rTMS among PLWHA who smoke. The current pilot study compared the effects of active and sham intermittent theta-burst stimulation (iTBS) on resting state functional connectivity (rsFC), cigarette cue attentional bias, and cigarette craving in PLWHA who smoke.

METHODS: Eight PLWHA were recruited (single-blind, within-subject design) to receive one session of iTBS (n=8) over the L. …

Case Report: The Effect Of Automated Manual Lymphatic Drainage Therapy On Lymphatic Contractility In 4 Distinct Cases, Melissa B Aldrich, John C Rasmussen, Ron J Karni, Caroline E Fife, Frank Aviles, Kristen A Eckert, M Mark Melin

Faculty, Staff and Student Publications

INTRODUCTION: Automated manual lymphatic drainage therapy (AMLDT) is available for home use in the form of a pneumatic mat of 16 pressurized air channels that inflate and deflate to mimic the stretch and release action of manual lymphatic drainage therapy. Four cases (a patient with complex regional pain syndrome and lymphedema, a healthy patient, a breast cancer survivor with chronic pain, and a patient with a history of abdominal surgery) underwent near-infrared fluorescence lymphatic imaging (NIRFLI) with AMLDT to evaluate the effect of AMLDT on lymphatic pumping and pain.

METHODS: Each patient received 32-36 injections of 25 μg indocyanine green …

New-Onset Diabetes Is A Predictive Risk Factor For Pancreatic Lesions In High-Risk Individuals: An Observational Cohort Study, Seyda Baydogan, Chirayu Mohindroo, Merve Hasanov, Maria F Montiel, Pompeyo Quesada, Irina M Cazacu, Adrianna A Luzuriaga Chavez, Maureen E Mork, Wenli Dong, Lei Feng, Y Nancy You, Banu Arun, Eduardo Vilar, Powel Brown, Matthew H G Katz, Suresh T Chari, Anirban Maitra, Eric P Tamm, Michael P Kim, Manoop S Bhutani, Florencia Mcallister

Faculty, Staff and Student Publications

BACKGROUND AND OBJECTIVES: Pancreatic cancer (PC) is the third cause of cancer-related deaths. Early detection and interception of premalignant pancreatic lesions represent a promising strategy to improve outcomes. We evaluated risk factors of focal pancreatic lesions (FPLs) in asymptomatic individuals at hereditary high risk for PC.

METHODS: This is an observational single-institution cohort study conducted over a period of 5 years. Surveillance was performed through imaging studies (EUS or magnetic resonance imaging/magnetic resonance cholangiopancreatography) and serum biomarkers. We collected demographic characteristics and used univariate and multivariate logistic regression models to evaluate associations between potential risk factors and odd ratios (ORs) …

Systemic Treatment Of Patients With Metastatic Breast Cancer: Asco Resource-Stratified Guideline Q And A, Sana Al Sukhun, Bogda Koczwara, Sarah Temin, Banu K Arun

Faculty, Staff and Student Publications

The Systemic Treatment of Patients with Metastatic Breast Cancer: @ASCO Resource-Stratified Guideline Q and A presents takeways, rationale, and key recommendations based on #JCOGO full guideline for patients by menopausal and marker status.

Developing Medical Genetics In A Low-Income Country: Unveiling The Journey Of The Pakistani Society Of Medical Genetics And Genomics (Psmg), Aisha Furqan, Syed A Ahmed, Rizwan Naeem, Myla Ashfaq

Faculty, Staff and Student Publications

No abstract provided.

Cancel Carte Blanche For The Information Industries: Federalizing U.C.C. Article 2., Michael L. Rustad

Missouri Law Review

Warranty disclaimers, caps on damages, predispute mandatory arbitration, and anti-class action waivers constitute what I call, “no responsibility” or “rights foreclosure clauses” in computer contracts. This is the first empirical study of how the information industries, which include the 100 largest software companies and the 100 largest digital companies, deploy one-sided warranty disclaimers, caps on damages, and predispute mandatory arbitration clauses coupled with class action waivers to shift responsibility for defective software to the user communities. This gives the information industries carte blanche to release dangerously defective software without consequences. In their standard form contracts, the industries do whatever they …

Usp22 Overexpression Fails To Augment Tumor Formatiaon In Mmtv-Erbb2 Mice But Loss Of Function Impacts Mmtv Promoter Activity, Xianghong Kuang, Andrew Salinger, Fernando Benavides, William J Muller, Sharon Y R Dent, Evangelia Koutelou

Faculty, Staff and Student Publications

The Ubiquitin Specific Peptidase 22 (USP22), a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) histone modifying complex, is overexpressed in multiple human cancers, but how USP22 impacts tumorigenesis is not clear. We reported previously that Usp22 loss in mice impacts execution of several signaling pathways driven by growth factor receptors such as erythroblastic oncogene B b2 (ERBB2). To determine whether changes in USP22 expression affects ERBB2-driven tumorigenesis, we introduced conditional overexpression or deletion alleles of Usp22 into mice bearing the Mouse mammary tumor virus-Neu-Ires-Cre (MMTV-NIC) transgene, which drives both rat ERBB2/NEU expression and Cre recombinase activity from the MMTV promoter resulting …

Mouse Models Of Chronic Lymphocytic Leukemia And Richter Transformation: What We Have Learnt And What We Are Missing, Maria Teresa Sabrina Bertilaccio, Shih-Shih Chen

Faculty, Staff and Student Publications

Although the chronic lymphocytic leukemia (CLL) treatment landscape has changed dramatically, unmet clinical needs are emerging, as CLL in many patients does not respond, becomes resistant to treatment, relapses during treatment, or transforms into Richter. In the majority of cases, transformation evolves the original leukemia clone into a diffuse large B-cell lymphoma (DLBCL). Richter transformation (RT) represents a dreadful clinical challenge with limited therapeutic opportunities and scarce preclinical tools. CLL cells are well known to highly depend on survival signals provided by the tumor microenvironment (TME). These signals enhance the frequency of immunosuppressive cells with protumor function, including regulatory CD4

Judging Our New Judges: Why We Must Remove Artificial Intelligence From Our Courtrooms Now, Kieran Duffy Newcomb

Honors Theses and Capstones

In this paper, I explore some of the ways in which artificial intelligence might enhance the sentencing process through recidivism prediction technology. Notably, this technology can increase the accuracy of risk predictions and the speed with which sentencing decisions are reached. I then show, however, that the recidivism prediction technology is likely to turn into what data scientist Cathy O’Neil calls a Weapon of Math Destruction. The potential harmfulness of this technology is due not to the inherent nature of the technology, but the symbiotic relationship it will have with our already harmful criminal justice system. I argue that the …

Artificial Intelligence And The Entertainment Industry, Caroline Rae Mccarthy

Honors Theses and Capstones

Artificial intelligence is a fast-growing technology that is quickly taking over many industries, such as the entertainment industry. Artificial intelligence has the capability to replicate voices, create fake videos and photos, called deepfakes, of just about anything, and can practically bring people back to life. This technology, as it stands now, is similar to the wild west because in the vast majority of places, it’s lawless. Artificial intelligence is growing so rapidly that lawmakers haven’t had a chance to keep up. This paper explains more of what AI does in everyday life, and how its abilities can impact the entertainment …

Developing A Gender Diverse Stimulus Set For Emotion Expressions, Amir Robertson

Honors Theses and Capstones

Much past research has demonstrated that gender plays an important role in emotion perception, such that gendered stereotypes about emotion seem to shape how we perceive and interpret the emotion expressions of men and women. However, the stimulus sets that are typically used in the vast majority of this research have been based on binary ideas of gender, and purposefully limit common elements of gender presentation, with models posing with limited accessories or personal aesthetic choices. In everyday life, however, individuals’ gender and gender presentation are not limited in these ways and likely contribute in important ways to how we …

Implementation Of Stronger Community Resilience In The United States Before Natural Disasters Strike, Andrew J. Widdekind

Honors Theses and Capstones

Since 2000, the United States has not sustained viable mitigation and preparedness solutions to combat the frequent and intense onset of natural disasters; more must be done on how communities can adapt and withstand them. Instead, environmental and human-induced factors have exacerbated the likelihood of these threats, which has caused billion-dollar weather events to occur more often. This paper focuses on how congressional policymakers would have to incorporate new mitigation/preparedness approaches into current emergency management methodology by creating a new federal statute known as the National Resiliency Act (or similar). A policy like this would strengthen the overall resilience of …

An Updated Outline For Clearing And Staining Of Preserved Specimens, Sadie E. Smith

Honors Theses and Capstones

This protocol outlines a enhanced clearing and staining procedure for persevered specimens, focusing on the visualization of cartilage and bone in small taxa. With origins from O. Shultze's diaphonization methodology in 1897, the process of clearing and staining improves the clarity and contrast of intricate tissues. It is essential for studies in developmental biology, histology and anatomy. This protocol covers the key steps of the process while detailing the materials, solutions and estimated timeline for each step pertaining to specific taxa. The aim of the protocol is to standardize and provide guidance for procedures in the Biological Sciences department at …

Creating A Positive Learning Environment: Preliminary Results, Kien H. Lim, Hilda Y. Sotelo

Departmental Papers (Math)

No abstract provided.

Death, Bankruptcy, And The Public Hospital, Michael A. Francus

Journal Articles

From the Article

This Article expands the purview of bankruptcy scholarship to those government businesses, assessing how Chapter 9 operates for them. It does so by taking public hospitals as a case study, offering a comprehensive look at every public-hospital bankruptcy between 1988 and 2021.

Integration Of Osteopathic Manipulative Treatment For Patients With Chronic Pain, Sharon Gustowski, Turner Slicho, D'Angeleau Newsome

Faculty and Staff Publications

The Five Models of Osteopathic Medicine offers guidance on creating a treatment plan that includes OMT for patients with chronic pain. Using OMT on one body region or system has numerous downstream effects and can influence multiple models. This paper describes this therapeutic modality.

Morphometry Of The Superior Ophthalmic Vein Unaffected By Dilating Factors, Farida Mehrhoff, Melissa Zolnierz, Alla Barry, Shelby Kuhnert, Mary Kilmer, Dmitry E. Tsyplakov, Robert Hillard

Faculty and Staff Publications

Context:
Data on the superior ophthalmic vein (SOV) dilation captivate the attention of neurologists as an early sign of several neurovascular disease manifestations, but measurements vary widely in publications.

Aims:
This study attempts to shed light on disparate data and develop more stringent criteria for determining the dilation of these veins.

Settings and Design:
To this end, 44 orbits of 25 formalin-embalmed human cadavers without risk factors for SOV dilation were dissected.

Materials and Methods:
The SOV branching pattern and length were photographed, and multiple segments were analyzed microscopically, histologically, and statistically.

Statistical Analysis Used:
Simple descriptive statistics as well …

Human Platelet Derived Mitochondrial Opa-1 Isoforms And Interaction With Tdp-43 In Neurodegenerative Diseases, Su Han Lee, Duyen Pham, Edina Kosa, Abdulbaki Agbas

Faculty and Staff Publications

Optic atrophy 1 (OPA-1) is a GTPase protein that controls mitochondrial fusion, cristae integrity, and mtDNA maintenance. In neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), the mitochondrial network morphology is compromised. Studies on TAR-DNA binding protein 43 (TDP-43) has been the focus in our lab. OPA-1 and TDP-43 interaction may shed a light on how aberrant TDP-43 interacts with OPA-1, which will lead to mitochondrial dysfunction. The preliminary study tested the idea of whether OPA-1 and TDP-43 are physically interacting in human platelet derived mitochondria obtained from healthy human subjects.

Ideological Leanings In Likely Pro Bono Biglaw Amicus Briefs In The United States Supreme Court, Derek T. Muller

Journal Articles

Each term, the United States Supreme Court receives hundreds of amicus briefs filed in merits docket cases. Many of the largest law firms file amicus briefs before the United States Supreme Court. These amicus briefs are often pro bono, which means the clients do not pay for the firm to file the brief. That pro bono work can quickly total millions of dollars of legal briefing subsidized by the law firm. And pro bono work often reflects the law firm’s desire to work for its prior commitments to what it identifies as the "public good."

Controversies have arisen in recent …

Developing A Professional Identity: Lessons For Women, Bipoc, And First Generation Law Students From The Canaries In The Coalmines, Christine Venter

Journal Articles

From the Article

This Article explores the concept of professional identity formation in the law, particularly as it pertains to women and lawyers of color. The topic of professional identity formation is an understudied area in legal education, despite the ABA’s new Standard 303(b)(3), which requires law schools to provide substantial opportunities for the development of professional identity. In the legal field, professional identity is often conflated with professionalism, which leads to confusion about how law schools should best prepare their students for their professional lives, and fails to fully equip students to join the profession.

Studies from other professions …

Assessing The Completeness Of Patient-Reported Outcomes Reporting In Congestive Heart Failure Clinical Trials, Drayton Rorah, Jonathan Pollard, Corbin Walters, Will Roberts, Micah Hartwell, Christian Hemmerich, Matt Vassar

Student Publications

Objective: We aim to evaluate the quality of patient-reported outcomes included in randomized control trials for the treatment of congestive heart failure using the International Society for Quality of Life Research (ISOQOL) checklist, a validated tool for critically appraising the quality of patient-reported outcomes.

Design: We performed a cross-sectional analysis of 65 randomized control trials with patient-reported outcomes for drug intervention trials for treating congestive heart failure.

Setting: N/A.

Participants: N/A.

Main outcome measures: The primary outcome of this study was to evaluate the reporting completeness of patient-reported outcomes in congestive heart failure clinical trials with drug interventions according to …

Examining The Influence Of Secondary Math And Science Teacher Preparation Programs On Graduates' Instructional Quality And Persistence In Teaching, Danielle M. Rhemer, Will Rogers, Sherry Ann Southerland

Teaching & Learning Faculty Publications

This quantitative, non-experimental study explored the relationship between the features of math and science teachers’ preparation programs and their graduates’ instructional rigor and persistence in teaching. Five math and science teacher preparation programs from across the United States were examined. Six sets of instructional tasks were collected from forty-six recent graduates of these programs to provide insights into novices’ instructional rigor, and employment data were collected for thirty-seven of these graduates three to eight years after graduation. Regardless of the program’s features, all teachers could design and implement instruction with moderate to high rigor. However, this ability was not the …

On The Whitewashing Of Third Space In Teacher Education, Or Don’T Cite This Manuscript, Jori S. Beck

Teaching & Learning Faculty Publications

Since the 1980s, there has been a push in teacher education to increase clinical experiences and build closer relationships between school districts and colleges of education. In 2010, Zeichner introduced the theory of Third Space to school-university partnership research. This was followed by a number of other articles in which the researchers applied the same theory—including in much of the work on teacher residencies. In this theoretical critique and brief systematic literature review, I connect Third Space theory back to its postcolonial roots and attribute the scholars of color who created the theory. I unpack the theory’s original intent and …