Digital Commons Network^™

Tumor-Resident Microbes: The New Kids On The Microenvironment Block, Le Li, Vidhi Chandra, Florencia Mcallister

Faculty, Staff and Student Publications

Tumor-resident microbes (TRM) are an integral component of the tumor microenvironment (TME). TRM can influence tumor growth, distant dissemination, and response to therapies by interfering with molecular pathways in tumor cells as well as with other components of the TME. Novel technologies are improving the identification and visualization of cell type-specific microbes in the TME. The mechanisms that mediate the role of TRM at the primary tumors and metastatic sites are being elucidated. This knowledge is providing novel perspectives for targeting microbes or using microbial interventions for cancer interception or therapy.

Randomized Phase 2 Trial Of Tremelimumab And Durvalumab In Combination Versus Sequentially In Recurrent Platinum-Resistant Ovarian Cancer, Emily M Hinchcliff, Anne Knisely, Naomi Adjei, Bryan Fellman, Ying Yuan, Ami Patel, Cai Xu, Shannon N Westin, Anil K Sood, Pamela T Soliman, Aaron Shafer, Nicole D Fleming, David M Gershenson, Raghunandan Vikram, Tharakeswara Bathala, David Vining, Dhakshina M Ganeshan, Karen H Lu, Charlotte C Sun, Larissa A Meyer, Amir A Jazaeri

Faculty, Staff and Student Publications

BACKGROUND: Single-agent immune checkpoint inhibitors (ICIs) have demonstrated limited responses in recurrent ovarian cancer; however, 30%-40% of patients achieve stable disease. The primary objective was to estimate progression-free survival (PFS) after sequential versus combination cytotoxic T-lymphocyte antigen 4 and programmed death ligand 1 ICIs in patients with platinum-resistant high-grade serous ovarian cancer (HGSOC).

METHODS: Patients were randomized to a sequential arm (tremelimumab followed by durvalumab on progression) or a combination arm (tremelimumab plus durvalumab, followed by durvalumab) via a Bayesian adaptive design that made it more likely for patients to be randomized to the more effective arm. The primary end …

Pulsed Electric Fields Sensitize Methicillin-Resistant Staphylococcus Aureus To Antibacterial Therapies And Stimulate Host Immune Responses, Alexandra E. Chittams-Miles

Biomedical Sciences Theses & Dissertations

This research explores the impact of nanosecond pulsed electric fields (nsPEF) on two fronts: their immune stimulatory effects and their potential as a novel strategy to enhance the sensitivity of Methicillin-resistant Staphylococcus aureus (MRSA) to clinically relevant antibiotics. While pulsed electric fields have been reported to have an immune stimulatory effect, the mechanisms responsible for these effects have yet to be determined.

Our investigation addresses the rising concern of MRSA derived skin and soft tissue infections (SSTIs). Consistent with other publications, we found that nsPEF alone cause modest inactivation of planktonic MRSA. We then investigated the effects of nsPEF in …

The Correlational Effects Of Academic And Demographic Factors On Nursing Students’ Attrition, Progression, And Completion At A University College Of Nursing, Adebusola A. Obafemi

Electronic Theses and Dissertations

High United States nursing student attrition rates have attracted political, organizational, and social interest for numerous reasons. This attrition places financial burdens on the students, results in revenue loss for the college, and exacerbates the existing nursing shortage. Students' success in a nursing program is crucial for nurses to practice nursing. The purpose of this retrospective study was to explore the effects of academic performance and demographic/categorical factors on nursing students' progression and completion at a University College of Nursing in the Southern United States. The target population consisted of students enrolled at the University College of Nursing from January …

Cattle Industry Funding Scheme Annual Report 2022/2023, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity published reports

In June 2010 the Cattle Industry Funding Scheme (IFS) was introduced to address biosecurity threats relevant to the Western Australian (WA) cattle industry. The Scheme was established under the Biosecurity and Agriculture Management Act 2007 to enable cattle producers to identify the pest and disease priorities at a whole-of-industry level and to raise funds for activities to address these priorities.

There are currently three Industry Funding Schemes in operation. In addition to the Cattle IFS, there is a Sheep and Goat IFS and a Grains, Seeds and Hay IFS. The three IFSs operate in a similar manner.

The purpose of …

Sir Fractional Order Of Covid-19 By Adams Bashforth-Moulton Method, Zubaidah Sadikin, Zaileha Md Ali, Fatin Nadira Rusly, Nuramira Husna Abu Hassan, Siti Rahimah Batcha, Noratika Nordin

Malaysian Journal of Computing (MJoC)

This study addresses a research gap by introducing fractional order derivatives into the SIR model for tracking COVID-19 in Malaysia. The Caputo sense fractional derivative and the Adams Bashforth Moulton method are employed to analyse the COVID-19 behavior and stability. By manipulating fractional order derivative values, this study investigates their impact on key SIR parameters, observing that lower values accelerate the attainment of asymptotic behavior in populations. The stability analysis reveals two equilibrium points: an unstable disease-free equilibrium and a stable endemic equilibrium within the system. This pioneering exploration of fractional order derivatives in the context of Malaysia's COVID-19 modeling …

Predicting Covid 19 Trends A Deep Dive Into Time Dependent Sirsd With Deep Learning Technique, Abdul Basit, Jasni Mohamad Zain, Abdul Kadir Jumaat, Nur’Izzati Hamdan, Hafiza Zoya Mojahid

Malaysian Journal of Computing (MJoC)

The COVID-19 pandemic, also known as Coronavirus Disease 2019, has affected over 700 million people globally, resulting in approximately 7 million deaths. Research has proposed multiple mathematical models to institute a disease transmission framework and predict the disease growth. Most of the existing mathematical disease growth prediction models are less effective due to the exclusion of the re-susceptible scenarios and overlooks their timedependent properties, which change continuously during the viral transmission process. Another popular prediction technique is deep learning approaches. However, existing methods often fail to accurately capture the dynamic trends of epidemics during their spreading phases in short-term and …

Infected Pulmonary Hydatid Cyst: A Challenging Diagnosis, Fahad M. Alrashed, Dayel A. Alshahrani

Saudi Medical Journal

ABSTRACT Echinococcosis is a parasitic infection that is distributed worldwide. Its clinical presentation depends on the size and location of the cyst. A 7-year-old was found with a superimposed infected pulmonary hydatid cyst that was initially misdiagnosed as complicated pneumonia. Our case underscores the challenges of diagnosing and managing echinococcosis, emphasizes the need for a high index of suspicion, and describes the disease’s ability to mimic other clinical entities.

Teaching Global Health Law: Preparing The Next Generation For Future Challenges, Lawrence O. Gostin, Sarah L. Bosha, Benjamin Mason Meier

Georgetown Law Faculty Publications and Other Works

Following from sweeping law reforms across the global health landscape, there is a need to prepare the next generation to advance global health law to ensure justice for a healthier world. Educational programs across disciplines have increasingly incorporated the field of global health law, with new courses examining the law and policy frameworks that apply to the new set of public health threats, non-state actors, and regulatory instruments that structure global health. Such interdisciplinary training must be expanded throughout the world to prepare future practitioners to strengthen global health law — ensuring a foundation for global health in legal studies …

Etiology, Clinical, And Laboratory Profiles Of Meningitis A Sample Of Children, Raghad Najem, Arabiya Ali, Mushriq Hussein

Iraqi Postgraduate Medical Journal

BACKGROUND:Meningitis is a significant cause of morbidity and modality in children around the world. Early diagnosis and treatment are the most important way in prevention of the complications. OBJECTIVE:To estimate the frequency and types of meningitis, to describe various clinical and laboratory parameters, and to analyze mortality and early complications of childhood meningitis. PATIENTS AND METHODS:One hundred Children aged 1 month-l5 years admitted to children Welfare Teaching Hospital with clinical suspicion of meningitis during the period from 18 September 2007 to 15 March 2008 were included in this study. They were subjected to clinical examination, blood tests, cerebrospinal fluid tests …

Analytical Challenges In Omics Research On Asthma And Allergy: A National Institute Of Allergy And Infectious Diseases Workshop, Supinda Bunyavanich, Patrice M Becker, Matthew C Altman, Jessica Lasky-Su, Carole Ober, Karsten Zengler, Evgeny Berdyshev, Richard Bonneau, Talal Chatila, Nilanjan Chatterjee, Kian Fan Chung, Colleen Cutcliffe, Wendy Davidson, Gang Dong, Gang Fang, Patricia Fulkerson, Blanca E Himes, Liming Liang, Rasika A Mathias, Shuji Ogino, Joseph Petrosino, Nathan D Price, Eric Schadt, James Schofield, Max A Seibold, Hanno Steen, Lisa Wheatley, Hongmei Zhang, Alkis Togias, Kohei Hasegawa

Center for Medical Ethics and Health Policy Staff Publications

Studies of asthma and allergy are generating increasing volumes of omics data for analysis and interpretation. The National Institute of Allergy and Infectious Diseases (NIAID) assembled a workshop comprising investigators studying asthma and allergic diseases using omics approaches, omics investigators from outside the field, and NIAID medical and scientific officers to discuss the following areas in asthma and allergy research: genomics, epigenomics, transcriptomics, microbiomics, metabolomics, proteomics, lipidomics, integrative omics, systems biology, and causal inference. Current states of the art, present challenges, novel and emerging strategies, and priorities for progress were presented and discussed for each area. This workshop report summarizes …

Rocscholar Annual Report 2023, Lisa M. Buda

Rochester Regional Health authored publications and proceedings

RocScholar is the institutional repository (IR) for Rochester Regional Health (RRH) and is managed by the Libraries at RRH. It provides storage and access for RRH’s research and scholarly activity. This report highlights the repository’s third year of implementation.

Severity Of Respiratory Syncytial Virus Vs Covid-19 And Influenza Among Hospitalized Us Adults, Diya Surie, Jennie H Kwon, Et Al.

2020-Current year OA Pubs

IMPORTANCE: On June 21, 2023, the Centers for Disease Control and Prevention recommended the first respiratory syncytial virus (RSV) vaccines for adults aged 60 years and older using shared clinical decision-making. Understanding the severity of RSV disease in adults can help guide this clinical decision-making.

OBJECTIVE: To describe disease severity among adults hospitalized with RSV and compare it with the severity of COVID-19 and influenza disease by vaccination status.

DESIGN, SETTING, AND PARTICIPANTS: In this cohort study, adults aged 18 years and older admitted to the hospital with acute respiratory illness and laboratory-confirmed RSV, SARS-CoV-2, or influenza infection were prospectively …

Who's Essential Medicines And Aware: Recommendations On First- And Second-Choice Antibiotics For Empiric Treatment Of Clinical Infections, Lorenzo Moja, Sumanth Gandra, Et Al.

2020-Current year OA Pubs

The WHO Model List of Essential Medicines (EML) prioritizes medicines that have significant global public health value. The EML can also deliver important messages on appropriate medicine use. Since 2017, in response to the growing challenge of antimicrobial resistance, antibiotics on the EML have been reviewed and categorized into three groups: Access, Watch, and Reserve, leading to a new categorization called AWaRe. These categories were developed taking into account the impact of different antibiotics and classes on antimicrobial resistance and the implications for their appropriate use. The 2023 AWaRe classification provides empirical guidance on 41 essential antibiotics for over 30 …

Optimizing Malaria Control: Granular And Cost-Effective Mosquito Habitat Index In Endemic Areas Through Satellite Imagery, Nur Ainun Daulay, Salwa Rizqina Putri, Arie Wahyu Wijayanto, Ika Yuni Wulansari

Knowledge Engineering and Data Science

Malaria, classified as a tropical disease under the Sustainable Development Goals (SDGs) indicator 3.3, remains a significant global health challenge. In this study, by taking advantage of multiple spectral composite indexes of multisource satellite imagery to capture various geospatial features relevant to the suitability of marsh mosquito habitat, we introduced the Mosquito Habitat Suitability Index (MHSI) to assess potential Anopheles mosquito breeding sites in terms of the vegetation density, water bodies, environment temperature, and humidity in any particular areas. The MHSI integrates the publicly accessible granular level of the normalized difference vegetation index, water index, land surface temperature, and moisture …

Relevance Of Lymphocyte Proliferation To Pha In Severe Combined Immunodeficiency (Scid) And T Cell Lymphopenia, Roshini S Abraham, Amrita Basu, Jennifer R Heimall, Elizabeth Dunn, Alison Yip, Malika Kapadia, Neena Kapoor, Lisa Forbes Satter, Rebecca Buckley, Richard O'Reilly, Geoffrey D E Cuvelier, Sharat Chandra, Jeffrey Bednarski, Sonali Chaudhury, Theodore B Moore, Hilary Haines, Blachy J Dávila Saldaña, Deepakbabu Chellapandian, Ahmad Rayes, Karin Chen, Emi Caywood, Shanmuganathan Chandrakasan, Mark Thomas Vander Lugt, Christen Ebens, Pierre Teira, Evan Shereck, Holly Miller, Victor Aquino, Hesham Eissa, Lolie C Yu, Alfred Gillio, Lisa Madden, Alan Knutsen, Ami J Shah, Kenneth Desantes, Jessie Barnum, Larisa Broglie, Avni Y Joshi, Gary Kleiner, Jasmeen Dara, Susan Prockop, Caridad Martinez, Talal Mousallem, Joseph Oved, Lauri Burroughs, Rebecca Marsh, Troy R Torgerson, Jennifer W Leiding, Sung Yun Pai, Donald B Kohn, Michael A Pulsipher, Linda M Griffith, Luigi D Notarangelo, Morton J Cowan, Jennifer Puck, Christopher C Dvorak, Elie Haddad

Faculty, Staff and Students Publications

Severe combined immunodeficiency (SCID) is characterized by a severe deficiency in T cell numbers. We analyzed data collected (n = 307) for PHA-based T cell proliferation from the PIDTC SCID protocol 6901, using either a radioactive or flow cytometry method. In comparing the two groups, a smaller number of the patients tested by flow cytometry had < 10% of the lower limit of normal proliferation as compared to the radioactive method (p = 0.02). Further, in patients with CD3+ T cell counts between 51 and 300 cells/μL, there was a higher proliferative response with the PHA flow assay compared to the 3H-T assay (p < 0.0001), suggesting that the method of analysis influences the resolution and interpretation of PHA results. Importantly, we observed many SCID patients with profound T cell lymphopenia having normal T cell proliferation when assessed by flow cytometry. We recommend this test be considered only as supportive in the diagnosis of typical SCID.

Hand Hygiene Practices Among Nurses In South Sulawesi Hospitals, Muhammad Rizky Asfarada, Rini Rachmawaty, Andina Setyawati, Gulzar Malik

Media Kesehatan Masyarakat Indonesia

Healthcare professionals’ adherence to hand hygiene protocols is paramount to prevent Healthcare-Associated Infections (HAIs) and ensure patient safety. This study evaluates compliance with the World Health Organization's (WHO) "Five-Moment Hand Hygiene" protocol among nurses in two Indonesian hospitals: Regional General Hospital X in Makassar City and Provincial General Hospital Y in South Sulawesi Province. A total of 60 nurses participated, with demographic analysis revealing significant differences between the hospitals. Utilizing a comprehensive observation tool provided by the WHO, data analysis indicated variations in hand hygiene practices, particularly after touching patient surroundings. Despite these differences, the data followed a normal distribution, …

Covid-19 Cases And Factors Associated With 11 Indonesian Provinces, 2021, Mugi Wahidin, Wawan Ridwan, Doni Lasut, Aan Kurniawan, Yurika Fauzia Wardhani

Media Kesehatan Masyarakat Indonesia

In collaboration with other stakeholders, National Task Force of COVID-19 Control conducted massive detection of the cases, followed by contact tracing. The study aimed to overview COVID-19 cases from 58 districts of 11 provinces in Indonesia and its associated factors. A cross-sectional study design used secondary data from The National Task Force of COVID-19 Control. COVID-19 cases and other variables were collected in 58 districts in 11 provinces of Indonesia year 2021. The study incorporated descriptive, correlation, and multiple linear regression analysis with the district as an analysis unit. The median of COVID-19 cases was 804 per district, traced cases …

Did Covid-19 Disrupt The Stock Market Return And Volatility? A Meta-Analytic Approach, Masagus M. Ridhwan, Solikin M. Juhro, Affandi Ismail, Peter Nijkamp, Kelvin Ramadhan Hidayat

Bulletin of Monetary Economics and Banking

We provide a quantitative synthesis of the literature utilizing meta-regression analysis on the measurable effect of the combined health and economic crisis due to the COVID-19 pandemic on stock market returns and volatility. This study is conducted based on 104 studies published during the period 2020 to 2022. We find strong evidence of a negative publication bias for COVID-19 impacts on stock market returns and a positive bias on volatility. We document that COVID-19 has a moderate negative effect on stock market returns. Estimates based on intraday stock returns show a greater effect compared to those using daily returns, whereas …

An Abnormal Presentation Of Rocky Mountain Spotted Fever: A Case Report, Joshua J. Nelson, Kaedon Buchmiller, Michael J. Valentine, Kirthika Lakshmanan, Ankur Kayastha, Jagjot S. Dhingra, Riley G. Fisher, Connor A. Parry, Annie K. Konrad, Arman Mughal, Carol E. Kirila

Student Publications

The intracellular coccobacilli Rickettsia rickettsii causes Rocky Mountain Spotted Fever, a potentially fatal illness. This bacterium is transmitted to humans through a tick vector. Patients classically present with a triad of symptoms, including fever, headache, and a rash that begins on the extremities and spreads proximally to the trunk. Diagnosis of this disease can prove difficult when patients have unusual symptoms, such as hypertensive crisis. In this case report, we present a 29-year-old male who arrived at the emergency room with altered mental status and a hypertensive crisis after his family reported one week of changes in his behavior. The …

Covid-19 Vaccine Effectiveness Among People Living With And Without Hiv In South Carolina, Usa: Protocol Of A Population-Based Cohort Study, Xueying Yang, Jiajia Zhang Ph.D., Bankole Olatosi, Sharon Weissman, Xiaoming Li Ph.D.

Faculty Publications

Introduction Despite the effectiveness of COVID-19 vaccines in preventing severe COVID-19 outcomes, a small percentage of fully vaccinated persons will develop symptomatic or asymptomatic infections with SARSCoV-2, which is referred to as ‘breakthrough COVID-19’. People living with HIV (PLWH) appear to have an elevated risk of severe COVID-19 outcomes, yet the effectiveness of the COVID-19 vaccine in this population remains unclear due to the limited research efforts in this population in the real world. This study aims to characterise and compare the breakthrough COVID-19 (eg, prevalence and disease severity) between PLWH and non-PLWH and then examine whether HIV markers play …

Assessing The Effectiveness Of Copper Oxide Nanoparticles (Cuo-Nps) As Larvicidal Agents Against Aedes Aegypti Larvae In A Laboratory Setup, Muhammad Ahsan Riaz, Ayesha Riaz, Muhammad Asif Mahmood, Muhammad Uzair Mukhtar, Waseem Akram, Ehtisham Arshad, Zaib Un Nisa, Beenish Ijaz, Muhammad Shahid Rasool

Journal of Bioresource Management

The control of Aedes aegypti (A. aegypti), the primary vector for dengue virus, requires effective larvicidal agents to target larvae breeding in various water sources. This study aimed to assess the effectiveness of Copper Oxide Nanoparticles (CuO-NPs) as larvicidal agents against A. aegypti larvae in a laboratory setup. Larvae were exposed to CuO-NPs at five contrasting concentrations (0, 5, 10, 20, and 30 mg/l). Twenty-five fourth instar larvae were subjected to each concentration with three replicates and one control with the same number (n=25) of larvae under optimum laboratory conditions. The larval mortality was calculated after 24 hours. …

A Review On Trichomonas Vaginalis And The Impact Of Some Demographic Variables On The Prevalence In Iraq, Wesam Jasim Hansh

Maaen Journal for Medical Sciences

Trichomoniasis is a parasitic disease that infects the genitourinary system in humans and is caused by Trichomonas vaginalis. This disease has a high classification among non-viral sexually transmitted diseases in the world comprising Iraq. The Data in the present review about prevalence of T. vaginalis in Iraq were collected using databases such as (Iraqi Academic scientific Journals, Google scholar, Medline and pubMed) based on the recent studies. The current review exhibited that the highest infection rate by this parasite in females was 75.22%, 62% in Maysan and Tikrit provinces respectively, and the lowest infection rate was 1.6% and 1.66% …

The Impact Of Essential Amino Acids On The Gut Microbiota Of Broiler Chickens, Thyneice Taylor-Bowden, Sarayu Bhogoju, Collins N. Khwatenge, Samuel N. Nahashon

Agricultural and Environmental Sciences Faculty Research

The research involving the beneficial aspects of amino acids being added to poultry feed pertaining to performance, growth, feed intake, and feed conversion ratio is extensive. Yet currently the effects of amino acids on the gut microbiota aren’t fully understood nor have there been many studies executed in poultry to explain the relationship between amino acids and the gut microbiota. The overall outcome of health has been linked to bird gut health due to the functionality of gastrointestinal tract (GIT) for digestion/absorption of nutrients as well as immune response. These essential functions of the GI are greatly driven by the …

Authentication Of Cybernetic Avatars And Legal System Challenges; With A View To The Trial Concept Of New Dimensional Domain Jurisprudence (Ai, Robot, And Avatar Law), Fumio Shimpo

Japanese Society and Culture

This article aims to illustrate the basis for the development of authentication, which will be the foundation of future cybernetic-avatar (CA) infrastructures, enabling the safe and secure use of CA’s. This will be realised by the authentication of CA operators (User Authentication Technology), identification and authentication of CA’s (CA Authentication), and ensuring connectivity and existence between operators (User Entities) and the CA’s themselves (CA Notarisation). An ELSI (Ethical, Legal, Social Implications) research platform will be established, to develop a new dimension of the legal field, that is, AI, Robot, and Avatar Law to solve the social issues and realise an …

A New Federalist Approach To Reducing Gun Violence: Model State Policy For Medicaid-Funded, Hospital-Based Violence Intervention Programs, Racquel Bozzelli

Buffalo Law Review

No abstract provided.

Using Dematel, Clustering, And Fuzzy Logic For Supply Chain Evaluation Of Electric Vehicles: A Scor Model, Mehrbakhsh Nilashi, Rabab Ali Abumalloh, Hossein Ahmadi, Mesfer Alrizq, Hamad Abosaq, Abdullah Alghamdi, Murtaza Farooque, Syed Salman Mahmood

School of Nursing and Midwifery

The transportation sector is considered among the major sources of greenhouse gas emissions. Given advancements in transportation technology, customers’ willingness to reduce carbon footprints, as well as policy incentives, Electric Vehicles (EVs) are becoming an increasingly important part of the passenger vehicle industry. Evaluation of Supply Chain (SC) performance in the EV industry seems to contribute significantly to the enhancement of the operational consequences across the supply chain tiers. The SCOR (Supply Chain Operations Reference) model was designed to help businesses optimize their supply chain operations, reduce costs, and improve customer satisfaction. Although many performance measurement models have been developed …

Non-Thermal Plasma Reduces Hsv-1 Infection Of And Replication In Hacat Keratinocytes In Vitro, Julia Sutter, Jascha Brettschneider, Brian Wigdahl, Peter Bruggeman, Fred Krebs, Vandana Miller

Kimmel Cancer Center Faculty Papers

Herpes simplex virus type 1 (HSV-1) is a lifelong pathogen characterized by asymptomatic latent infection in the trigeminal ganglia (TG), with periodic outbreaks of cold sores caused by virus reactivation in the TG and subsequent replication in the oral mucosa. While antiviral therapies can provide relief from cold sores, they are unable to eliminate HSV-1. We provide experimental results that highlight non-thermal plasma (NTP) as a new alternative therapy for HSV-1 infection that would resolve cold sores faster and reduce the establishment of latent infection in the TG. Additionally, this study is the first to explore the use of NTP …

Antitumor Efficacy And Safety Of Unedited Autologous Cd5car T Cells In Relapsed/Refractory Mature T-Cell Lymphomas, Laquisa C Hill, Rayne H Rouce, Mengfen J Wu, Tao Wang, Royce Ma, Huimin Zhang, Birju Mehta, Natalia Lapteva, Zhuyong Mei, Tyler S Smith, Lina Yang, Madhuwanti Srinivasan, Phillip M Burkhardt, Carlos A Ramos, Premal Lulla, Martha Arredondo, Bambi Grilley, Helen E Heslop, Malcolm K Brenner, Maksim Mamonkin

Center for Medical Ethics and Health Policy Staff Publications

Despite newer targeted therapies, patients with primary refractory or relapsed (r/r) T-cell lymphoma have a poor prognosis. The development of chimeric antigen receptor (CAR) T-cell platforms to treat T-cell malignancies often requires additional gene modifications to overcome fratricide because of shared T-cell antigens on normal and malignant T cells. We developed a CD5-directed CAR that produces minimal fratricide by downmodulating CD5 protein levels in transduced T cells while retaining strong cytotoxicity against CD5⁺ malignant cells. In our first-in-human phase 1 study (NCT0308190), second-generation autologous CD5.CAR T cells were manufactured from patients with r/r T-cell malignancies. Here, we report safety …

Association Of Nightly Fasting, Meal Frequency, And Skipping Meals With Metabolic Syndrome Among Kuwaiti Adults, Fatema Alkhulaifi, Suad Al-Hooti, Sameer Al-Zenki, Husam Alomirah, Qian Xiao, Wenyaw Chan, Fuqing Wu, Charles Darkoh

Faculty, Staff and Student Publications

Mounting evidence suggests that meal timing and frequency are associated with cardiometabolic health by influencing circadian rhythms. However, the evidence is inconsistent and limited, especially in non-Western cultures. This cross-sectional study aims to investigate the association between temporal habits of dietary intake, such as nightly fasting duration and meal frequency, and metabolic syndrome among Kuwaiti adults. A 24-hour recall was used to assess temporal habits of dietary intake. Meal frequency was defined as the number of daily eating episodes. The study included a total of 757 adults aged 20 years and older. The participants' mean age was 37.8 ± 12.3 …