Digital Commons Network^™

Dna G-Quadruplexes As Targets For Natural Product Drug Discovery, Kai-Bo Wang, Yingying Wang, Jonathan Dickerhoff, Danzhou Yang

Purdue University Libraries Open Access Publishing Fund

DNA guanine (G)-quadruplexes (G4s) are unique secondary structures formed by two or more stacked G-tetrads in G-rich DNA sequences. These structures have been found to play a crucial role in highly transcribed genes, especially in cancer-related oncogenes, making them attractive targets for cancer therapeutics. Significantly, targeting oncogene promoter G4 structures has emerged as a promising strategy to address the challenge of undruggable and drug-resistant proteins, such as MYC, BCL2, KRAS, and EGFR. Natural products have long been an important source of drug discovery, particularly in the fields of cancer and infectious diseases. Noteworthy progress has recently been made in the …

Short- And Long-Term Predicted And Witnessed Consequences Of Digital Surveillance During The Covid-19 Pandemic: Scoping Review, Leigha Comer, Lorie Donelle Phd, Rn, Fcan, Bradley Hiebert, Maxwell J. Smith, Anita Kothari, Saverio Stranges, Jason Gilliland, Jed Long, Jacquelyn Burkell, Jacob J. Shelley, Jodi Hall, James Shelley, Tommy Cooke, Marionette Ngole Dione, Danica Facca

Publications

BACKGROUND: The COVID-19 pandemic has prompted the deployment of digital technologies for public health surveillance globally. The rapid development and use of these technologies have curtailed opportunities to fully consider their potential impacts (eg, for human rights, civil liberties, privacy, and marginalization of vulnerable groups). OBJECTIVE: We conducted a scoping review of peer-reviewed and gray literature to identify the types and applications of digital technologies used for surveillance during the COVID-19 pandemic and the predicted and witnessed consequences of digital surveillance. METHODS: Our methodology was informed by the 5-stage methodological framework to guide scoping reviews: identifying the research question; identifying …

Flattening The Curve: Why Amending The International Health Regulations Is The Common-Sense Solution To Future Pandemics, Brittney Graff

BYU Law Review

The COVID-19 pandemic presented an unprecedented challenge for the World Health Organization (WHO) and international community. The outbreak and ongoing pandemic prompted States to reassess the efficacy of the International Health Regulations (IHR). In November 2021, the World Health Assembly (WHA) decided to develop a new agreement to increase international pandemic preparedness. This paper analyzes the current gaps in the IHR to present a pragmatic approach wherein the WHA would amend rather than replace the IHR. It starts by examining the purpose and history of the IHR, including past revisions. It then addresses the constitutional framework of the IHR, and …

Reversible Male Contraception By Targeted Inhibition Of Serine/Threonine Kinase 33, Angela F Ku, Kiran L Sharma, Hai Minh Ta, Courtney M Sutton, Kurt M Bohren, Yong Wang, Srinivas Chamakuri, Ruihong Chen, John M Hakenjos, Ravikumar Jimmidi, Katarzyna Kent, Feng Li, Jian-Yuan Li, Lang Ma, Chandrashekhar Madasu, Murugesan Palaniappan, Stephen S Palmer, Xuan Qin, Matthew B Robers, Banumathi Sankaran, Zhi Tan, Yasmin M Vasquez, Jian Wang, Jennifer Wilkinson, Zhifeng Yu, Qiuji Ye, Damian W Young, Mingxing Teng, Choel Kim, Martin M Matzuk

Faculty, Staff and Students Publications

Men or mice with homozygous serine/threonine kinase 33 (STK33) mutations are sterile owing to defective sperm morphology and motility. To chemically evaluate STK33 for male contraception with STK33-specific inhibitors, we screened our multibillion-compound collection of DNA-encoded chemical libraries, uncovered potent STK33-specific inhibitors, determined the STK33 kinase domain structure bound with a truncated hit CDD-2211, and generated an optimized hit CDD-2807 that demonstrates nanomolar cellular potency (half-maximal inhibitory concentration = 9.2 nanomolar) and favorable metabolic stability. In mice, CDD-2807 exhibited no toxicity, efficiently crossed the blood-testis barrier, did not accumulate in brain, and induced a reversible contraceptive effect that …

Urokinase-Type Plasminogen Activator Receptor (Upar) In Inflammation And Disease: A Unique Inflammatory Pathway Activator, Mostafa Hamada, Kyle S. Varkoly, Omer Riyadh, Roxana N. Beladi, Ganesh Munuswamy-Ramanujam, Alan Rawls, Jeanne Wilson-Rawls, Hao Chen, Grant Mcfadden, Alexandra R. Lucas

Student Publications

The urokinase-type plasminogen activator receptor (uPAR) is a unique protease binding receptor, now recognized as a key regulator of inflammation. Initially, uPA/uPAR was considered thrombolytic (clot-dissolving); however, recent studies have demonstrated its predominant immunomodulatory functions in inflammation and cancer. The uPA/uPAR complex has a multifaceted central role in both normal physiological and also pathological responses. uPAR is expressed as a glycophosphatidylinositol (GPI)-linked receptor interacting with vitronectin, integrins, G protein-coupled receptors, and growth factor receptors within a large lipid raft. Through protein-to-protein interactions, cell surface uPAR modulates intracellular signaling, altering cellular adhesion and migration. The uPA/uPAR also modifies extracellular activity, activating …

Health Equity: Communicating Impaired Water Status, Emily Potter

Virginia Journal of Public Health

Introduction: Land use changes in the Rivanna River and James River Watersheds have increased the number of impaired recreational waters, and there is a disparity in the equitable communication of these impairments to different populations. Ineffective communication contributes to inequities in access to safe, accessible, and affordable water for vulnerable populations, placing public health at risk.

Methods: This study uses secondary data from the Environmental Protection Agency’s Watershed Index Online (WSIO) Indicator Data Tables, Virginia Department of Environmental Quality (DEQ), Rivanna River Association, and James River Association. Correlations, linear regression, and percent change were used to identify statistically significant trends …

Mentorship Matters: Promising Results From Vpha’S Pilot Mentorship Program, Ashley Tharpe, Stacey B. Plichta, Anna R. Robertson, Kim Baskette

Virginia Journal of Public Health

Purpose

The Virginia Public Health Association (VPHA) Pilot Mentorship Program seeks to support public health students, early career professionals, and career switchers throughout the Commonwealth of Virginia in their growth as public health professionals. The program provides opportunities for participants to gain job-seeking and professional communication skills through live webinars, to connect with each other through online networking events, to manage stress through wellness webinars, and to interact with experienced public health professionals.

Methods

VPHA formed a volunteer committee to develop and implement the program in Fall 2022. Initially, the program was envisioned as a traditional one-to-one mentoring program; however, …

Virginia Journal Of Public Health Spring 2024

Virginia Journal of Public Health

No abstract provided.

Factors Affecting Adherence To Antiretroviral Therapy Among People Living With Hiv/Aids In Antigua And Barbuda, Yuliecia Antoinette Rowe-Harris Mrs, Chirlynor Ebora Calbayan Mrs, Kepha Odiwuor Pondi Mr

Adventist Human-Subject Researchers Association

This study examined factors affecting adherence to antiretroviral therapy (ART) among people living with HIV/AIDS in Antigua and Barbuda. The findings identified multiple variables, emphasizing the dynamic components affecting ART adherence. These findings address a local gap and provide insights into the unique adherence challenges faced by a vulnerable population.

Medical School Watercooler Newsletter - May 23, 2024, Lindsey Lyle

Watercooler Newsletter

This is the May 23, 2024 edition of the Frederick P. Whiddon College of Medicine’s newsletter - Watercooler.

Contents Include

• Tuckey earns Outstanding Young Scientist Award at research symposium
• Graduate student earns national scholarship for research
• Basic medical sciences student wins Stanford BioX Award
• M3 Case Symposium set for June 7
• Pediatric patients may rate pain differently than caregivers, study finds

Efficacy Of Ferula L. Species Extracts From Tajikistan Against Influenza Viruses, Saidbeg Satorov, Sulhiy Mavlonazarova, Ahdrey P. Bogoyavlenskiy, Salomuddin D. Yusufi, Vyacheslav Dushenkov

Publications and Research

Efficacy of Ferula L. Species Extracts from Tajikistan Against Influenza Viruses One of the challenges facing both the domestic and international pharmaceutical industries is the limited selection and suboptimal efficacy of available antiviral drugs. The high mutational variability of influenza viruses contributes to rapid acquisition of drug resistance, which diminishes or nullifies the effectiveness of existing therapies, thereby necessitating the exploration for novel therapeutics. This study aimed to assess the antiviral activities of three species of the genus Ferula— indigenous to the Republic of Tajikistan—against influenza strains A/Vladivostok/2/09 (H1N1) and A/Almaty/8/98 (H3N2). The investigation revealed that phytochemical constituents—specifically, root …

Lateral Flow Devices: Applying Antigen-Antibody Interaction For Vaccine Technology, Mirna González-González, Marco Rito-Palomares

Vaccine Technology IX

Please click Additional Files below to see the full abstract.

Recombinant Interleukins As Vaccine Adjuvants Against Livestock Diseases, Berenice Calderón-Pérez, Leandro Alberto Nuñez-Muñoz, Ana María Cortés-López, Pedro Ricardo Rodríguez-Farrera, Roberto Ruiz-Medrano, Beatriz Xoconostle-Cázares, Areli Margarita Martínez-Morales

Vaccine Technology IX

Please click Additional Files below to see the full abstract.

Acheviements Of A Vaccine Development Unit Within Lmics; Biotechnology Development Unit, Institut Pasteur De Tunis, Tunisia, Samia Rourou, Amani Chaabene, Said Salhi, Samy Majoul, Khaled Trabelsi, Hana Askri, Hela Kallel

Vaccine Technology IX

Please click Additional Files below to see the full abstract.

Advances In Alternative Routes Of Vaccine Administration, And Continued Challenges, Tanima Sinha

Vaccine Technology IX

Please click Additional Files below to see the full abstract.

Break Through The Mold: Hyper-Ige Syndrome As A Vehicle For Invasive Aspergillosis, Stephen Smetana Do, Joseph Nordin Do, Rachel Johnson Md, Angela Gableman Md, Nicholas Nassif Md, Ms

Scientific Day

No abstract provided.

Mycobacterium Avium Complex Vertebral Osteomyelitis And Retroperitoneal Abscess In An Immunocompetent Patient: A Case Report, Jacob Nelson Md, Kazi Khan Md, William Macdonald Md

Scientific Day

No abstract provided.

Peripheral Mononeuropathy In A Pediatric Patient Following Episode Of Severe Diabetic Ketoacidosis: A Case Report, Kelly Fahey Dpm, Andrew Silman Dpm, Eyad Xoubi Dpm, Patrick Sanchez Dpm

Scientific Day

No abstract provided.

May 22, 2024 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

No abstract provided.

A Fur Family Protein Bosr Is A Novel Rna-Binding Protein That Controls Rpos Rna Stability In The Lyme Disease Pathogen, Sajith Raghunandanan, Raj Priya, Fuad Alanazi, Meghan C. Lybecker, Paula Schlax, X. Frank Yang

All Faculty Scholarship

The σ54-σS sigma factor cascade plays a central role in regulating differential gene expression during the enzootic cycle of Borreliella burgdorferi, the Lyme disease pathogen. In this pathway, the primary transcription of rpoS (which encodes σS) is under the control of σ54 which is activated by a bacterial enhancer-binding protein (EBP), Rrp2. The σ54-dependent activation in B. burgdorferi has long been thought to be unique, requiring an additional factor, BosR, a homologue of classical Fur/PerR repressor/activator. However, how BosR is involved in this σ54-dependent activation remains unclear and perplexing. In this study, we demonstrate that BosR does not function as …

Sink Your Teeth Into A Curious Case Of Non-Infectious Mandibular Osteomyelitis, Kathryn Brady Do, Kelci Butler Do, Michael Tekippe Md, Phd

Scientific Day

No abstract provided.

Covid-19 Tort Reform, Clayton J. Masterman

Journal Articles

In 2020 and 2021, 44 states and Washington, D.C. passed laws that limited tort liability related to COVID-19. The most common reforms immunized health care providers from malpractice or similar liability. A second category is limited liability to individuals or businesses for exposing others to the novel coronavirus. And a third category protected manufacturers of supplies used to detect and prevent COVID- 19 from products liability suits. The goals of these reforms included protecting health care providers from uncertainty in providing care for a novel disease, limiting the macroeconomic consequences of the pandemic, and encouraging the distribution of critical supplies …

Sjogren’S Induced Splenic Atrophy Leading To Overwhelming S. Pneumoniae Bacteremia And Purpura Fulminans, Daniel Jabr Do, Navedeep Kaur Do, Hector Roman-Perez Md, Daniel Strama Do, Daniel Grahf Md

Scientific Day

No abstract provided.

A Local Rebound In Adult Invasive Group A Streptococcus (Igas) After Recent Pediatric Igas Outbreak, Nikolina Madjer Md, Daniel Rowan Do, Leon Eydelman Md, Valerie Em Griffeth Md, Phd

Scientific Day

No abstract provided.

Effectively Managing Communication After A Crisis: A Phenomenographic Study On Public Health Crises In The Country Of Jamaica, Jehan Donnique Wilson

Walden Dissertations and Doctoral Studies

Effectively managing communication after a crisis is the starting point of successful public policy and administration when handling a public health crisis. Jamaica has dealt with several public health crises over the span of its existence; this study compared SARS-CoV-2 (COVID-19) and influenza, two major Jamaican public health crises during the period from 2019 to 2022. This study’s research questions addressed (a) what specific communication strategies were used by Jamaica during the influenza outbreak as compared to the COVID-19 pandemic and (b) how the specific communications strategies used during the influenza outbreak and COVID-19 pandemic contributed to the development of …

Podiatrists' Experiences With Telemedicine During Covid-19, Jeavon Inniss

Walden Dissertations and Doctoral Studies

Telemedicine was one of the most beneficial technologies to improve patient access to care during the COVID-19 pandemic. Telemedicine has been well-researched in the hospital and primary care setting. There is a paucity of research that has focused on the experiences of specialty providers such as podiatrists. The purpose of this qualitative study was to understand podiatrists’ perspectives on the value of telemedicine as a method of delivering care. The unified theory of acceptance and use of technology was used as a theoretical framework to aid in identifying which factors are necessary for acceptance and continued use of telemedicine in …

Effects Of Covid-19 On Mental Health Workers' Job Satisfaction, Employee Burnout, And Intent To Leave, Colton Jacobs

Doctoral Dissertations and Projects

The COVID-19 disease emerged in December 2019 and created a worldwide pandemic. As the COVID-19 virus spread, healthcare workers faced increased workloads and burnout due to increased stress. With a current abundance of research to better understand how the pandemic affected healthcare workers, minimal research has been conducted to investigate the effects on mental health workers. It is imperative to better understand how the consequences of the pandemic affected mental health workers due to their importance in supporting the mental well-being of our communities. This study focused on how the COVID-19 pandemic influenced job satisfaction, burnout syndrome, and intent to …

The Stratified Leadership Model Of The First-Century Christian Church, Barton Schuyler Garratt Edsall Iv

Doctoral Dissertations and Projects

As Christianity enters its third millennium, it faces the sharpest decline in the number of people attending church congregations compared to the total population. In Romans 1:13, the Apostle Paul states that God’s people should not be ignorant that the purpose for leaders within the collective church body, beginning with himself as the example, is so the people’s lives would be fruitful–spiritually enriched and productive. Logic dictates that if the lives of those who attended Christian churches in the twenty-first century experienced and displayed such spiritual quality, attendance would not be declining but contrarily on the rise. Regarding church clergy …

Twist1 Drives Cytotoxic Cd8+ T-Cell Exhaustion Through Transcriptional Activation Of Cd274 (Pd-L1) Expression In Breast Cancer Cells, Xiaobin Yu, Jianming Xu

Faculty, Staff and Students Publications

In breast cancer, epithelial-mesenchymal transition (EMT) is positively associated with programmed death ligand 1 (PD-L1) expression and immune escape, and TWIST1 silences ERα expression and induces EMT and cancer metastasis. However, how TWIST1 regulates PD-L1 and immune evasion is unknown. This study analyzed TWIST1 and PD-L1 expression in breast cancers, investigated the mechanism for TWIST1 to regulate PD-L1 transcription, and assessed the effects of TWIST1 and PD-L1 in cancer cells on cytotoxic CD8+ T cells. Interestingly, TWIST1 expression is correlated with high-level PD-L1 expression in ERα-negative breast cancer cells. The overexpression and knockdown of TWIST1 robustly upregulate and downregulate PD-L1 …

Preparing Three Southern Baptist Churches In Mason, Tennessee, As Lighthouses Of Hope In Crisis And Disaster: The Intersection Of The Firehouse And The Church House During A Global Pandemic, Brian J. Styer

Doctoral Dissertations and Projects

The Southern Baptist Disaster Relief (SBDR) ministry program faces challenges due to limited awareness among Southern Baptist pastors, leading to inadequate promotion and participation. The proposed solution involves providing targeted education, improved advertising, and encouraging local leaders to promote engagement. The project aims to prepare three churches in Mason and Stanton, TN, to serve as Disaster Relief teams through specialized training and courses like ‘Introduction to Disaster Relief.’ The goal is to increase awareness of SBDR, recruit and train new members, and inspire individuals to become endorsed SBDR and Public Safety Chaplains. The project incorporates a theological foundation to integrate …