Digital Commons Network^™

Menstrual Personal Hygiene Behavior Among Adolescents With Physical And Intellectual Disabilities, Nur Khotimah Elfiyani, Agustin Kusumayati, Caroline Endah Wuryaningsih, Kemal Nazaruddin Siregar

Kesmas

Reproductive health for adolescents with disabilities is often disregarded, and education on personal hygiene is insufficient because some people perceive menstruation as a sensitive topic and have a false belief that adolescents with disabilities have no sexual desire. This study aimed to determine the overview of personal hygiene behavior among adolescents with physical and intellectual disabilities when facing menstruation. The method used was qualitative, with case studies, in-depth interviews, and observations for data collection. The informants comprised four adolescents aged 19-21 years, two mothers, and two therapists for special needs children. This study was conducted at two growth and development …

Multifactoral Immune Modulation Potentiates Durable Remission In Multiple Models Of Aggressive Malignancy, Matthew M Halpert, Briana A Burns, Spencer R Rosario, Henry G Withers, Akshar J Trivedi, Colby J Hofferek, Benjamin D Gephart, Haotong Wang, Jonathan Vazquez-Perez, Sharon B Amanya, Sean T Hyslop, Jianhua Yang, Jan O Kemnade, Vlad C Sandulache, Vanaja Konduri, William K Decker

Faculty, Staff and Students Publications

Tumors typically lack canonical danger signals required to activate adaptive immunity and also frequently employ substantial immunomodulatory mechanisms that downregulate adaptive responses and contribute to escape from immune surveillance. Given the variety of mechanisms involved in shielding tumors from immune recognition, it is not surprising that single-agent immunomodulatory approaches have been largely unsuccessful in generating durable antitumor responses. Here we report a unique combination of immunomodulatory and cytostatic agents that recondition the tumor microenvironment and eliminate complex and/or poor-prognosis tumor types including the non-immunogenic 4T-1 model of TNBC, the aggressive MOC-2 model of HNSCC, and the high-risk MYCN-amplified model of …

Examining The Association Of Type 2 Diabetes Mellitus Risk Factors Between African Immigrants Living In The United States And African Americans Born In The United States, Philip Effiong

Walden Dissertations and Doctoral Studies

The purpose of the study was to investigate the risk factors for Type 2 diabetes mellitus (T2DM) among African immigrants and African Americans born in the United States to identify differences and similarities in their impact and prevalence. Variables considered as potential differentiators included alcohol consumption, income, educational levels, and smoking habits, age, and gender. The health belief model served as the theoretical framework. Utilizing data from the National Health and Nutrition Examination Survey 2015-2016, logistic regression analyses were used to test for significant factors affecting T2DM prevalence in these groups. Results indicated that country of origin did not predict …

Vaccine Uptake And Intentions: Insights From A Texas Survey On Factors Influencing Covid-19 Vaccination Decisions, Yordanos M Tiruneh, Paula M Cuccaro, Kimberly S Elliott, Jing Xie, Journey Martinez, Mark Owens, Christian R Alvarado, Jose-Miguel Yamal

Faculty, Staff and Student Publications

The effectiveness of COVID-19 vaccines depends on widespread vaccine uptake. Employing a telephone-administered weighted survey with 19,502 participants, we examined the determinants of COVID-19 vaccine acceptance among adults in Texas. We used multiple regression analysis with LASSO-selected variables to identify factors associated with COVID-19 vaccine uptake and intentions to receive the vaccine among the unvaccinated. The prevalence of unvaccinated individuals (22%) was higher among those aged 18-39, males, White respondents, English speakers, uninsured individuals, those facing financial challenges, and individuals expressing no concern about contracting the illness. In a fully adjusted regression model, higher odds of being unvaccinated were observed …

Depressive Symptoms And Substance Use Behaviors Among Young Adults Before And During Covid-19, Sarah Chun

Clinical Psychology Dissertations

Exposure to previous public health disasters have been found to have a significant negative impact on young adult mental health. Thus, it is important to examine the effect that COVID-19 had on young adult mental health. The current study examined differences in depressive symptoms as well as frequency and impairment of substance use in two cross-sectional samples of undergraduate students, one before COVID-19 and one during COVID-19. This study also examined the moderating effects of religiosity on the association between COVID-19 status and both depressive symptoms and substance use behaviors. Participants were 898 young adults (M_age = 19.83, …

Harvesting Justice In The Land Of The Free: A Call For Legislative Reform For Immigrant Farmworker Rights, Leah Burnett

Immigration and Human Rights Law Review

This article delves into the complex legal landscape surrounding farmworker rights, shedding light on a demographic often marginalized and overlooked within the broader scope of labor and immigration law. Despite their indispensable contributions to the agricultural industry, farmworkers frequently face a myriad of challenges, ranging from hazardous working conditions to limited access to basic labor protections. Drawing from legal analysis, empirical research, and real-life cases, this paper explores the historical context, current legal framework, and pressing issues concerning farmworker rights in the United States.

Beginning with an examination of the historical roots of farm labor exploitation, the article elucidates the …

Development Of A Multi-Target Pharmacophore-Based Virtual Screening Agent Against Covid-19, Nashwa A. Ibrahim, Ahmed M. Gouda, Hany A. M. El-Sherief

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The worldwide outbreak of the COVID-19 pandemic compelled scientists to develop new, highly effective therapeutic approaches to fight it. Multitarget drugs have been proven to be effective in managing complex disorders. But designing multitarget drugs is a great challenge. In this study, to prevent a lack of efficacy due to viral mutation escape, a multi-target agent against the COVID-19 virus was discovered. As crucial targets, RNA-dependent RNA polymerase (RdRp), COVID-19 main protease (Mpro), and SARS-CoV-2 Nsp15 were selected. A pharmacophore model was developed using the native ligands of the chosen targets. This model was used to screen the ZINC Drug …

Detecting Coral Reef Presence Using Icesat-2 Data And Machine Learning Methods, Gabrielle Trudeau, Lowell Kim

Center for Coastal and Ocean Mapping

As ocean temperatures and sea levels continue to increase and weather storms become more severe and frequent, benthic habitats such as coral reefs become more vulnerable to deadly conditions such as mass bleaching events and infectious diseases. With these ever-changing conditions, it becomes imperative that monitoring efforts are made to ensure longevity of the world’s coral reefs. Current coral reef monitoring techniques require significant manpower to collect in-situ data, such as fixed site surveys using photography and visual counts. The Ice, Cloud, and land Elevation Satellite-2 (ICESat-2), while initially intended for collecting data regarding changes in the cryosphere, utilizes a …

Black Women Dying To Give Life, Teresa Gray

Publications and Research

ABSTRACT

Maternal Mortality is a prevalent problem that impacts the overall health of the nation. This predicament has been touted by presidential candidates, political leaders, obstetrical leaders, midwifery, nursing and obstetrical organizations as an urgent problem that needs to be addressed. The United States has the worst maternal mortality among high-income countries. Although the impact of maternal mortality on other groups such as Whites, Asians and Hispanics must be recognized and acknowledged, this paper focuses on its impacts on Black women. Black women are disproportionately losing their lives due to pregnancy related complications more than any other group. The contributory …

Innovation In Bioinformatics: Recent Tools, Database And Involvement Of Artificial Intelligence, Aziz Ahmed, Mohd Shuaib, Abdulbasid Banga, Rizwan Ahmad

Indonesian Journal of Medical Chemistry and Bioinformatics

Bioinformatics has evolved in recent years into a crucial subject and a well-liked research area that is interconnected with many approaches and disciplines. The capacity of bioinformatics and its approaches to tackle challenging biological problems and promote research and development. There are various tools and database which are used in bioinformatics. AI is the capacity of a computational system to carry out various activities associated with intellectual beings and as a computer system's imitation of human intelligence processes. The bioinformatics applications with artificial intelligence have the capacity to annotate the data in the direction of logical conclusions. By combining AI …

Management Overview Of The Lung Tuberculosis Control Program At The Dki Jakarta Provincial Health Office In 2023, Mutiara Kiranti, Helen Andriani

Journal of Indonesian Health Policy and Administration

Tuberculosis is one of the infectious diseases that is fatal if not cured immediately. In 2022, the success rate of tuberculosis treatment in DKI Jakarta Province is 81%, while the national target is 90%. In the field, the number of cadres to carry out contact investigations is still insufficient, so that in 2022 the coverage of contact investigations in DKI Jakarta Province will only reach 25%, while the national target is 90%. To increase the scope of successful treatment, the government should try to overcome tuberculosis, which is needed. Proper program management is required to run effectively and efficiently for …

Island Health Crisis: Bridging Gaps In Indonesia's Healthcare Deserts, Joyce Mangoma, Wahyu Sulistiadi

Journal of Indonesian Health Policy and Administration

This narrative literature review examines critical healthcare challenges in Indonesia's island communities, focusing on workforce shortages, inadequate health infrastructure, and the profound impact of geographical and socioeconomic factors. Drawing from eight studies published between January 2000 and December 2023, the discussion highlights both the strengths and weaknesses of existing research. The studies were selected based on their relevance to healthcare issues in island communities, rigorous methodological approaches, and significant insights into healthcare challenges and solutions. This time frame was chosen to encompass a comprehensive evolution of healthcare challenges and responses, particularly considering the effects of the COVID-19 pandemic. Grounded in …

Immune Responses Of Neonatal (14-Day Old) And Adult (6 Weeks Old) Mice Lung And Spleen Cells To Gamma-Irradiated Mycobacterium Tuberculosis Stimulation, Oyinkansola F. Adeyemi

Biotechnology Theses

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is a global health challenge, especially in vulnerable populations like neonates, whose immune systems are still developing. Understanding the immune responses to Mtb in neonates is critical for the development of better vaccine and treatment strategies. Building upon previous research from our laboratory, which demonstrated that γMtb stimulated neonatal mice (0, 3, and 7 days old) lung cells displayed distinct cytokine profiles and increased expansion of myeloid-derived suppressor cell subpopulations than adult mice lung cells. In the current study, we investigated age-dependent immune responses in 14-day-old (neonates) and 6-week-old (adults) mice. We found …

Generation And Characterization Of Lipid Nanoparticles For Dna Plasmid Delivery And Pharmacological Characterization, Sahana John

Biotechnology Theses

Lipid nanoparticles (LNPs) have shown promise for delivering nucleic acids like DNA plasmids, but packaging large plasmids remains challenging. The findings and experimental work detailed in this thesis are geared towards providing a proof of concept and providing preliminary confirmation of the guiding principle.

We synthesized LNPs containing cationic lipids (D-Lin-MC3) to encapsulate the large pLVX-ZsGreen and psiCHECK (luciferase) plasmids (~10-14kb) using a microfluidic system. Characterization included size, charge, morphology, plasmid encapsulation efficiency and in vitro/in vivo studies. The LNP-pDNA particles were ~100nm in size with high encapsulation efficiency. The LNPs efficiently transfected 293T cells with low cytotoxicity, enabling strong …

Mitigating Burnout In Primary School Teachers Since The Covid-19 Pandemic, Janine Celeste Adrian

Walden Dissertations and Doctoral Studies

Although teacher burnout has been experienced for decades, teachers faced additional stressors with the onset of COVID-19. Teachers faced newfound stressors due to lockdowns and restrictions on gathering face-to-face and instruction becoming virtual. Even the youngest students (kindergarten to fifth grade) had to be taught according to the virtual learning mandates. As a result, primary school teachers began to experience burnout differently. The purpose of this study was to explore the support primary school teachers needed to help mitigate the burnout they experienced due to the COVID-19 pandemic. This study explored what interpersonal, intrapersonal, or educational support helps mitigate burnout …

Perceptions Of Pre-Service Teachers About Natural Disasters: Coronavirus, Earthquake, Fire, And Flood, Pınar Bozca, Eylem Yalçınkaya Önder

Journal of Educational Research and Practice

This research explores the perceptions of preservice teachers in Turkey in terms of their preparedness for various disasters, including epidemics, earthquakes, fires, and floods, all of which have profound social and economic impacts on education. Using a descriptive survey model, the study examined the responses of 512 preservice teachers at a single university across all levels of their educational program. The survey, conducted digitally due to the pandemic, consisted of 70 questions. Findings reveal inconsistent levels of confidence and readiness across different types of disasters. For instance, while most preservice teachers understand the severity of the coronavirus and are concerned …

Crisis Management: Unveiling Information And Communication Technologies’ Revamped Role Through The Lens Of Sub-Saharan African Countries During Covid-19, Ruthbetha Kateule, Egidius Kamanyi, Mahadia Tunga

The African Journal of Information Systems

The management of COVID-19 pandemic has revealed inefficiencies in coordinating global response, particularly in African countries. Therefore, creating an urgent need to examine the literature on Information and Communication Technologies (ICT) in crisis management to appreciate its contextual role. Employing a systematic review, using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), this paper critically assessed the extent of the use of ICT in crisis management in Africa’s response to COVID-19 to reconstruct its resilience against future crises. Findings indicate that while countries with limited ICT infrastructure faced considerable challenges in utilizing ICT solutions in COVID-19 management, countries …

An Interactive Web Application For Exploring Systemic Lupus Erythematosus Blood Transcriptomic Diversity., Eléonore Bettacchioli, Laurent Chiche, Damien Chaussabel, Divi Cornec, Noémie Jourde-Chiche, Darawan Rinchai

Faculty Research 2024

In the field of complex autoimmune diseases such as systemic lupus erythematosus (SLE), systems immunology approaches have proven invaluable in translational research settings. Large-scale datasets of transcriptome profiling have been collected and made available to the research community in public repositories, but remain poorly accessible and usable by mainstream researchers. Enabling tools and technologies facilitating investigators' interaction with large-scale datasets such as user-friendly web applications could promote data reuse and foster knowledge discovery. Microarray blood transcriptomic data from the LUPUCE cohort (publicly available on Gene Expression Omnibus, GSE49454), which comprised 157 samples from 62 adult SLE patients, were analyzed with …

Seeking Asylum Somewhere Over The Rainbow: The Long-Term Effect Of Southern Border Restrictions Upon Lgbtq+ Asylum Seekers, London Jones

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

The Effect Of Educating Mas On Hpv Vaccination: A Pilot Project, Alexis Petersen, Karlen E. Luthy, Michael S. Robinson, Janelle L. B. Macintosh

Student Works

Background: The HPV vaccine protects patients against infection and cancers, yet it is underutilized. Medical Assistants (MAs) can play a pivotal role in vaccination and are the focus of this project.

Aim Statement: This project aims to examine whether one educational session can improve the perceptions, knowledge, and comfort level of MAs regarding HPV vaccination.

Methods: The project took place at three separate clinics of one pediatric organization in Utah.

Interventions: A 10–15-minute educational session about the HPV vaccine was presented to the MAs at each clinic, and a pre- and post-survey method was used to analyze the effect of …

Influence Of Social Media On Mothers' Decision-Making Regarding Vaccinations, Wendy M. Patterson

Dissertations

This study involved determining why mothers hesitate to vaccinate their children and where they get their information about vaccinations. This descriptive qualitative study guided by the health belief model explored the influence social media has on mothers' perceived barriers to vaccinating their children. A descriptive qualitative approach was used, and one-on-one audio interviews were conducted via Zoom or in person with 19 participants. Participants were mothers 19 or older, had children between zero and 18, made medical decisions for their children who resided in their household, and sought information about vaccinations via healthcare providers, social media platforms, friends, or family. …

T-Cell Redirecting Bispecific Antibodies: A Review Of A Novel Class Of Immuno-Oncology For Advanced Prostate Cancer, Julia Palecki, Amman Bhasin, Andrew Bernstein, Patrick Mille, William Tester, William Kelly, Kevin Zarrabi

Kimmel Cancer Center Faculty Papers

Novel T-cell immunotherapies such as bispecific T-cell engagers (BiTEs) are emerging as promising therapeutic strategies for prostate cancer. BiTEs are engineered bispecific antibodies containing two distinct binding domains that allow for concurrent binding to tumor-associated antigens (TAAs) as well as immune effector cells, thus promoting an immune response against cancer cells. Prostate cancer is rich in tumor associated antigens such as, but not limited to, PSMA, PSCA, hK2, and STEAP1 and there is strong biologic rationale for employment of T-cell redirecting BiTEs within the prostate cancer disease space. Early generation BiTE constructs employed in clinical study have demonstrated meaningful antitumor …

Reports Of Autosomal Recessive Disease And Consanguineous Mating Within The Human Population, Johnathon L. Schluter

Master's Theses

It is anecdotally evident when investigating published reports of autosomal recessive disease that a substantial number of cases are the result of related (consanguineous) mating. This research seeks to quantify the percent of manuscripts describing autosomal recessive diseases published between 2000 and 2020 in which consanguineous mating is indicated. We analyzed 602 peer-reviewed manuscripts to identify the percentage of cases presented in which consanguineous mating was indicated, the underlying genes (novel gene or new mutation) and geographical region. These papers were accessed through a specific set of parameters on the free access PubMed Central (PMC) database. A total of 552 …

Dublin Institute Of Technology (Dit) College Sites: A Fascicle Of Maps, Photographs, Images And Documents, Leonard Hynes, Phil Hanlon Dr., Anne Murphy

Level 3

No abstract provided.

Keep Our Children Smiling: Fluoride Varnish Education In The Pediatric Primary Care Setting, Isabella Mortola

Doctor of Nursing Practice Final Manuscripts

Background: Dental caries is the most common chronic childhood disease. In early childhood, it is associated with many negative factors such as pain, loss of teeth, and impaired growth. Fluoride varnish (FV) is a protective resin coating treatment that is reimbursable by most insurances and is recommended by the American Academy of Pediatrics (AAP), United States Preventative Services Task Force (USPSTF), and the American Dental Association (ADA) due to its high efficacy in preventing dental caries. FV is a low-cost treatment that can be easily applied in 1-2 minutes during a well-child visit in the primary care setting, where children …

Federal Powers In A Pandemic, Julia Whitehead, Braden Leach

Georgia State University Law Review

This Article examines how the young federal government responded to infectious diseases to ascertain the limits of federal powers and analyzes how federal powers were used in response to the COVID-19 pandemic.

Avidity Maturation Of Humoral Response Following Primary And Booster Doses Of Bnt162b2 Mrna Vaccine Among Nursing Home Residents And Healthcare Workers, Oladayo A. Oyebanji, Nicholas Sundheimer, Vaishnavi Ragavapuram, Brigid M. Wilson, Jürgen Bosch, Christopher L. King, David H. Canaday

Faculty Scholarship

Infections, despite vaccination, can be clinically consequential for frail nursing home residents (NHR). Poor vaccine-induced antibody quality may add risk for such subsequent infections and more severe disease. We assessed antibody binding avidity, as a surrogate for antibody quality, among NHR and healthcare workers (HCW). We longitudinally sampled 112 NHR and 52 HCWs who received the BNT162b2 mRNA vaccine after each dose up to the Wuhan-BA.4/5-based Omicron bivalent boosters. We quantified anti-spike, anti-receptor binding domain (RBD), and avidity levels to the ancestral Wuhan, Delta, and Omicron BA.1 & 4/5 strains. The primary vaccination series produced substantial anti-spike and RBD levels …

Synergizing Ai, Iot, And Blockchain For Diagnosing Pandemic Diseases In Smart Cities: Challenges And Opportunities, Ibrahim Alrashdi, Ali Alqazzaz

Sustainable Machine Intelligence Journal

The advent of smart cities has paved the way for transformative advancements in healthcare, particularly in the domain of disease diagnosis. In the wake of the COVID-19 pandemic, accurate and timely identification of Pandemic diseases has become paramount. This paper explores the challenges and opportunities in synergizing Artificial Intelligence (AI), Internet of Things (IoT), and Blockchain technologies for diagnosis of Pandemic diseases in smart cities. This study provides an overview of each technology and its relevance to sustainable healthcare in smart cities, emphasizing its potential for analyzing medical data and making informed decisions. We also explore how IoT devices can …

Review Of Treatment Of Hepatitis C Among Persons Who Are Housing Insecure And Use Substances, Kate Kelley

Faculty Scholarship

With the advent of direct-acting antiviral agents (DAA), reduction of hepatitis C infection (HCV) has become a public health priority. The World Health Organization’s goal of global elimination of HCV by 2030 has brought to light the challenges in treating certain populations. This review examines the burden of HCV infection on unhoused individuals and people who use substances in the United States in the last five years, and presents best practices in patient care and treatment.

Covid-19 Vaccine Motivation And Hesitancy Among A Sample Of African American, Afro-Caribbean, And African Respondents In The United States, Shauna K. Elbers, Denise A. Vaughan, Yordanos M. Tiruneh

School of Medicine Faculty Publications and Presentations

Understanding the motivations and decisions behind COVID-19 vaccine acceptance is crucial for designing targeted public health interventions to address vaccine hesitancy. We conducted a qualitative analysis to explore COVID-19 vaccine acceptance among diverse ethnic subgroups of Black Americans in the United States. This study investigates the 2021–2022 responses of 79 African American, Afro-Caribbean, and African respondents over the age of 18 in Washington State and Texas. Respondents were asked “Do you plan to get the COVID-19 vaccination?” Qualitative responses were analyzed by content category and ethnic subgroup. Of the 79 responses, 60 expressed favorable perceptions, 16 expressed unfavorable perceptions, and …