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The Effect Of Antibiotic Premedication On Postoperative Complications Following Dental Extractions, Jessina C. Mcgregor, Geneva M. Wilson, Gretchen Gibson, M. Marianne Jurasic, Charlesnika T. Evans, Katie J. Suda

Faculty and Staff Publications

Objectives

We aimed to evaluate the association between antibiotic prophylaxis and adverse outcomes following tooth extraction within the Veterans Affairs Healthcare System.

Methods

We conducted a retrospective cohort study of patients undergoing dental extractions in 2015–2019. The primary exposure was antibiotic prophylaxis. The primary outcome was post-extraction complication within 7 days (e.g., alveolar osteitis and surgical site infection); the secondary outcome was subsequent medical care relating to a post-extraction oral complication within 7 days. Multivariable logistic regression models assessed the independent effect of antibiotic prophylaxis on each outcome.

Results

Of 385,880 visits with a dental extraction, 122,810 (31.8%) received antibiotic …

Molecular Detection Of Pathogenic Bacteria In American Dog Ticks (Dermacentor Variabilis) In Brown County, Nebraska, Nicole Messbarger, Darby Carlson, Keith Geluso, Julie Shaffer

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

Ticks carry and transmit disease pathogens that cause many human illnesses. Many of these diseases in humans are accompanied by a wide variety of symptoms making tick-borne illnesses often difficult to diagnose. The rate of reported tick-borne illnesses in humans has increased during the past decades in the United States, alongside a rise in concern for public health and safety. In northern Nebraska, the American dog tick (Dermacentor variabilis) is the primary tick encountered by humans and domestic animals in the region. This species is a known vector for spotted fever group (SFG) rickettsioses and tularemia (Francisella …

Unilateral Facial Swelling In A Sickle Cell Patient., Rohan Akhouri, Alison L. Fowler, Colton Schwarz, Lina Patel

Manuscripts, Articles, Book Chapters and Other Papers

Acute soft head syndrome (ASHS) is a rare complication of sickle cell disease that often requires a high index of suspicion and is often a diagnosis of exclusion. We present the case of an 18-year-old male with sickle cell disease in the United States who developed acute soft head syndrome without known traumatic injury. The goal of this case presentation is to provide awareness and education regarding a rare complication of sickle cell disease and recommended management for the associated symptoms.

Impact Of Covid-19 On Hospital Expenses Of Diabetes And Obesity Patients In Rural Eastern North Carolina, Courtney Battle-Bradley

Walden Dissertations and Doctoral Studies

Multiple chronic conditions have caused a significant increase in hospital expenses. Diabetes and obesity have been identified as variables that negatively impact patient outcomes, but hospital expenses for diabetes and obesity patients who had and did not have COVID-19 had not been explored. The purpose of this quantitative correlational study was to compare the difference in hospital expenses, if any, of diabetes and obesity patients with and without COVID-19 at a North Carolina rural health care center. The study’s design was a correlational analysis using simple linear regression guided by Andersen’s behavioral model of health service utilization. The dependent variable …

Antibiotic Resistance In Livestock: A Literature Review Of Its Consequences And International Effort On Human Antimicrobial Agents Resistant Crisis, Ha Nguyen

Theses and Graduate Projects

Background: Despite their benefits, the overuse of antibiotics in livestock has resulted in negative consequences to human health and the augmenting of an antibiotic-resistant crisis. Countries worldwide have conducted analyses and confirmed the growth of bacterial strains immune to most antibiotics. The widespread use of antibiotics is shown in various sectors, including human medicine and agriculture, leading to the emergence of antibiotic-resistant bacterial strains.

Purpose: This comprehensive literature review focuses on finding the connection between the usage of antibiotics in livestock, the transfer of antibiotic resistance to humans through consumption and exposure, and international efforts to find solutions to antimicrobial …

Emotional Response In Working Memory Of Individuals With Latent Toxoplasmosis, Antonella Quimbayo

All HCAS Student Capstones, Theses, and Dissertations

Toxoplasma gondii is a prevalent parasite that infects about 30% of the world population. House cats and other felids serve as definitive hosts and acquire Toxoplasma by consuming infected prey, which are intermediate hosts. This includes rats and avians, but also large mammals such as wolves and deer. Toxoplasma gondii is known to manipulate prey behavior to enhance its transmission. For example, infected rodents demonstrates attraction to and curiosity around cat urine. Wolves infected with Toxoplasma were 11 times more likely to disperse from their pack and start a new pack. The manipulation of intermediate host behavior observed in rodents …

Central Nervous System Antiviral Pharmacology, Sean N. Avedissian

Theses & Dissertations

Soon after viral infection, viruses like Human Immunodeficiency Virus (HIV) and SARS-CoV-2 can disseminate throughout the body and establish reservoirs in the central nervous system (CNS). The persistence of viruses in cells of these reservoirs is a major obstacle to virus eradication. This is due to the abundance of cells/receptors that these viruses utilize to gain entry into cells found at these various reservoir sites. Consequently, these same anatomical sites also may be pharmacologic sanctuaries, as evidenced by concentrations of antiretroviral drugs (ARVs) and antivirals (AVs) that are lower in reservoirs than those in peripheral blood; in some cases, these …

Respiratory Syncytial Virus In The United States: A Research Proposal For A Prospective Cohort Study Of Rsv Vaccines, Kenneth D. Chiu

Master's Projects and Capstones

Objective

This paper proposes a phase IV study to estimate the effectiveness of Abryvso and Arexvy in older adults against severe RSV disease. Additionally, the study aims to assess factors involved with low vaccine uptake for these RSV vaccines.

Methods

For the background literature review of this proposal, I conducted a search of the PubMed and CINAHL Ultimate databases for articles on older adults and RSV. I filtered out results within the period of 2020 to 2024 that were publicly available and focused on RSV burden, vaccinations, or knowledge in the United States.

The proposed phased IV study is a …

Dying Right: Supporting Anti-Cancer Therapy Through Immunogenic Cell Death, Elizabeth Schmitz

Theses & Dissertations

The primary goal of most anti-cancer therapy is to eradicate neoplastic cells. Simultaneously, neoplastic cell death is the first step of the cancer-immunity cycle, which starts with the release of antigens from cancer cells and ends with T-cell directed killing of cancer cells, in addition to long-standing memory to tumor antigens encountered. Immunogenic damage-associated-molecular patterns (DAMPs) are endogenous cell molecules repurposed in times of insurmountable cell stress (e.g., CALR, ATP, HMGB1) to facilitate communication between dying cells and adaptive immune cells, acting as adjuvants for the cancer-immunity cycle, in a cellular fate termed immunogenic cell death (ICD). It …

Telehealth For Healthy Aging: A Multi-Level, Multi-Methods Approach, Vaibhavi Mone

Theses & Dissertations

Telehealth, rapidly adopted during the pandemic, has shown its usefulness and limitations, yet was not designed with older adults in mind. This dissertation encompasses three interconnected studies exploring telehealth utilization for Medicare Annual Wellness Visits (AWVs) among older adults, provider perspectives on telehealth AWVs, and the impact of teleconferencing on primary care providers' knowledge and confidence in geriatric care. The objectives are to determine patient characteristics using telehealth AWV (study 1), understand provider perspectives on telehealth AWV (study 2), and evaluate the effectiveness of geriatrics education through telehealth (study 3). Study 1 investigates the changes in AWV utilization among 18,405 …

Understanding The Role Of Malondialdehyde-Acetaldehyde Adducts (Maa) In Inflammatory Bowel Disease, Megan L. Otte

Theses & Dissertations

Inflammatory Bowel Disease (IBD) comprises autoimmune diseases of the gastrointestinal tract that greatly reduce the quality of life of patients and currently afflict up to 200 individuals per 100,000 Americans. Ulcerative colitis (UC) and Crohn’s Disease (CD), the two principal diseases comprising IBD, share symptoms and risk factors, however, precise etiology remains unclear. The diagnostics and clinical management of IBD have progressed greatly in recent years especially due to immune modulating therapies and biologics, however, IBD and its specific forms are still difficult to diagnose and cannot be cured with current treatments. The overarching mechanisms of IBD pathogenesis are known …

The Dissemination And Implementation Of N95 Fit Testing Capacities For Nebraska Long-Term Care Facilities: A Mixed-Methods Analysis Using The Re-Aim Framework, Anthony Blake

Theses & Dissertations

Background: Ensuring the proper fit of N95 respirators used by healthcare workers in long-term care facilities (LTCF) is essential for their safety. The Nebraska Department of Health and Human Services launched a LTCF strike team project (STP) in the summer of 2022, focused on increasing the number of staff trained in infection control and building internal capacity for LTCFs to fit test their employees. This study describes the N95 fit-testing initiative for Nebraska LTCFs.

Methods: Staff from all 19 local health departments (LHD) received “train-the-trainer” training to prepare LTCF staff to perform qualitative fit testing. LTCF administrators were requested to …

Inactivated Rabies-Based Lassa Fever Virus Vaccine Candidate Lassarab Protects Nonhuman Primates From Lethal Disease, Gabrielle Scher, Catherine Yankowski, Drishya Kurup, Nicole Josleyn, Eric Wilkinson, Jay Wells, Jesse Steffens, Ginger Lynn, Sean Vantongeren, Xiankun Zeng, Nancy Twenhafel, Kathleen Cashman, Matthias Schnell

Department of Microbiology and Immunology Faculty Papers

Lassa fever virus (LASV), a member of the Arenavirus family, is the etiological agent of Lassa fever, a severe hemorrhagic disease that causes considerable morbidity and mortality in the endemic areas of West Africa. LASV is a rodent-borne CDC Tier One biological threat agent and is on the World Health Organization's (WHO) Priority Pathogen list. Currently, no FDA-licensed vaccines or specific therapeutics are available. Here, we describe the efficacy of a deactivated rabies virus (RABV)-based vaccine encoding the glycoprotein precursor (GPC) of LASV (LASSARAB). Nonhuman primates (NHPs) were administered a two-dose regimen of LASSARAB or an irrelevant RABV-based vaccine to …

Characterization Of Population Pharmacokinetics And Associated Interindividual Variability Of Drugs Used In Mass Drug Administration Against Lymphatic Filariasis, Abdullah Alshehri

Theses & Dissertations

Lymphatic filariasis (LF) is a mosquito-borne filarial infection that affects the lymphatic system. The progression of the disease is associated with severe comorbidities and social stigma among patients. The World Health Organization has categorized the disease as a public health problem, and it has been targeted by mass drug administration (MDA) campaigns over the past two decades. Several preventive chemotherapies have been used in MDA campaigns against LF, including a combination of three anti-filarial drugs (IDA therapy): albendazole (ALB), diethylcarbamazine (DEC), and ivermectin (IVM). Other antiparasitic drugs, such as moxidectin (MOX), are still under investigation for their activity against LF. …

3d Chromatin Architecture, Brd4, And Mediator Have Distinct Roles In Regulating Genome-Wide Transcriptional Bursting And Gene Network, Pawel Trzaskoma, Seolkyoung Jung, Aleksandra Pękowska, Christopher H Bohrer, Xiang Wang, Faiza Naz, Stefania Dell'orso, Wendy D Dubois, Ana Olivera, Supriya V Vartak, Yongbing Zhao, Subhashree Nayak, Andrew Overmiller, Maria I Morasso, Vittorio Sartorelli, Daniel R Larson, Carson C Chow, Rafael Casellas, John J O'Shea

Faculty, Staff and Student Publications

Discontinuous transcription is evolutionarily conserved and a fundamental feature of gene regulation; yet, the exact mechanisms underlying transcriptional bursting are unresolved. Analyses of bursting transcriptome-wide have focused on the role of cis-regulatory elements, but other factors that regulate this process remain elusive. We applied mathematical modeling to single-cell RNA sequencing data to infer bursting dynamics transcriptome-wide under multiple conditions to identify possible molecular mechanisms. We found that Mediator complex subunit 26 (MED26) primarily regulates frequency, MYC regulates burst size, while cohesin and Bromodomain-containing protein 4 (BRD4) can modulate both. Despite comparable effects on RNA levels among these perturbations, acute depletion …

A Hermeneutic Phenomenological Study Of First-Year Christian Student Success In Theological Studies During The Pandemic, Philip Lamar Nash

Doctoral Dissertations and Projects

This study examined the journeys of first-year undergraduate theological students during the coronavirus (COVID-19) pandemic to figure out what, if anything, aided the students in completing their coursework with passing grades. COVID-19 has impacted organizations and individuals around the world, prompting changes to ensure that things kept moving forward safely. The research was conducted to discover what, if anything, brought about achievement for students in a COVID-19 collegiate environment. The research was guided through a hermeneutic phenomenological qualitative approach by conducting interviews with students about their first year in a residential secondary educational setting that moved to being online because …

The Impact Of Social Media Use On Maternal Vaccination Decisions, Natalie Raquel Flynn

Doctoral Dissertations and Projects

This quantitative study aimed to explore the impact of social networking sites (SNS) on maternal vaccination decisions. Utilizing purposive sampling, the study ensured a representative sample of mothers or expectant mothers over 18 years old, with at least one child under 18, residing in the United States. Participants completed a composite survey consisting of three individual surveys assessing social media usage, vaccination decisions, and information-seeking behaviors. Descriptive statistics were employed for comprehensive analysis, investigating the influence of accessing social media platforms on maternal COVID-19 vaccination decisions. The Shapiro-Wilk test assessed the normality of age, while frequencies, percentages, median, and interquartile …

The Experience Of Middle School Special Education Teachers In New Jersey Teaching Virtually During Covid-19, Yolanda Henderson

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study is to describe the experiences of middle school special education teachers working remotely in New Jersey during the COVID-19 pandemic. The conceptual framework that guided this study was Schlossberg’s Transition Theory. Schlossberg's Transition Theory refers to events that result in a change of relationships, routines, assumptions, or roles. This theory allowed me to see the various phases such as moving in, through, and out of the COVID-19 pandemic. Recognizing how the pandemic affected the relationships, routines, and roles of teachers made it easy to understand how this theory related directly to the pandemic. …

Put The Vanc Down, Flip It And Reverse It: Comparison Of Vancomycin And Daptomycin Health Care Utilization And Cost In Outpatient Parenteral Antimicrobial Therapy, Amber C. Streifel, Katie Luis, Monark Nakrani, Diana Yu, Monica K. Sikka, Cara D. Varley, Alyse Douglass, Heather Mayer, Kathleen Young, James S. Lewis Ii

OHSU-PSU School of Public Health Faculty Publications and Presentations

Vancomycin and daptomycin are frequently used in outpatient parenteral antimicrobial therapy (OPAT). We analyze health care utilization and cost to the health care system for vancomycin vs daptomycin in the outpatient setting and find that vancomycin results in significantly higher health care utilization and similar cost per course compared with daptomycin in OPAT.

Differences In Stress Among Healthcare Workers In Rural And Urban Healthcare Settings--The Role Of Spirituality, Lisa Yancey

Doctoral Dissertations and Projects

In recent years, stress has become an unspoken epidemic that has affected many working adults. Many adults spend much of their waking hours working, contributing to their stress. This quantitative study examined the relationship between spirituality and stress among rural and urban healthcare workers. The data for this study was collected through social media platforms, email, and word of mouth. An online survey consisting of ten demographic questions, twenty questions from the Spiritual Well-Being Scale, and ten questions from the Perceived Stress Scale was administered to healthcare workers at least 18 years old through an anonymous survey. Pearson correlations were …

The Transition From In Person Sessions To Telemental Health Sessions For College Counseling Center Counselors, Katherine L. Karimian

Doctoral Dissertations

This study was conducted by applying Interpretative Phenomenological Analysis (IPA) to explore the lived experiences of college counseling center (CCC) counselors during their rapid switch from in person to online services as a result of university and colleges moving to remote education during the peak of the COVID-19 pandemic (~March 2020 - August 2021). Six participants from different regions of the United States were interviewed via Zoom and analyzed through IPA. There were five themes that emerged:Blurred work/home boundaries, interpersonal relationships within work setting, adapting to teletherapy, impact of teletherapy on services, and preferring remote work. Emergent subthemes were parenting, …

Exploring Leadership Characteristics And Their Effects On Sustaining Federally Qualified Health Centers, Eleace E. Sawyers

Walden Dissertations and Doctoral Studies

An argument can be made for the continued existence of Federally Qualified Health Centers (FQHCs) because of the level of importance of the service they provide to society. The problem addressed in this research is that despite the millions of people in need of affordable health care, the leaders of many FQHCs are fighting to keep facilities open amidst financial struggles. The purpose of this research was to identify leadership characteristics that promote FQHCs’ success by assessing effective leadership styles. This study applied a quantitative, descriptive non-experimental approach. Probability sampling was used to select the sample size and the Multifactor …

Experiences With Therapeutic Adherence Among Hiv Positive Older Adults In Puerto Rico, Isaida Cabrera-Montero

Walden Dissertations and Doctoral Studies

HIV/AIDS infection, which originally was a fatal disease, is now a treatable, chronic disease with which people can live to reach 70 years of age or older if they comply with treatment. HIV treatment requires adherence to medications, but there is a lack of evidence on therapeutic adherence among older adults in Puerto Rico. The purpose of this descriptive phenomenology study, guided by the health belief model, was to provide a better understanding of HIV therapy adherence among older adults living in Puerto Rico. Semi structured interviews were conducted with 10 HIV-positive adults aged 65 years or older who were …

Partnering Across Professions: Public Health And Collaborative Courts Partnership To Increase Recovery Capital, Mikayla Aubry

Master's Projects and Capstones

Substance use disorder (SUD) has been steadily increasing over the past decade. The prevalence of SUD in the United States hit an all-time high of 48.7 million people struggling with SUD in 2022 (Tomko et al., 2022; United States (U.S.), 2023). State and federal policies have led to the criminalization of drug use, the dismantling of behavioral health systems, and mass incarceration of people with SUD. These policies have also created a cyclical cycle of failure and recidivism for people struggling with SUD. One intervention that has strived to rectify the mass incarceration of those struggling with SUD is the …

Effects Of Misinformation And Disinformation On Vaccine Hesitancy And Routine Vaccine Uptake, Cindy Chen

Master's Projects and Capstones

This literature review was conducted to identify the role misinformation and disinformation plays on the rates of vaccine hesitancy and vaccine uptake for routine immunization among the child and adult populations of the United States. Fifteen articles between 2018-2024 were extracted from PubMed and Google Scholar databases. As shelter-in-place and social distancing protocol wanes, the risk of common vaccine preventable diseases (VPDs) reemerges, especially in populations that have not kept up with routine immunization schedules. Current efforts to restore mass vaccination campaigns are underway, but do not provide the necessary modifications to include social, behavioral, and cultural factors that influence …

Waste Management Process And Malaria-Induced Child Mortality In Côte D’Ivoire., Kouame N'Guessan

Walden Dissertations and Doctoral Studies

Malaria-induced child mortality is a Sub-Saharan African phenomenon, and Côte d'Ivoire, in West Africa, has one of the highest rates. This general qualitative study investigates waste management as a potential factor of malaria-induced child mortality to inform policy changes and fill a gap in the body of knowledge. The study is grounded in Skocpol's policy feedback theoretical framework. The research question explored aspects of waste management in Côte d'Ivoire which contribute to the high rate of malaria-induced child mortality. Eighteen participants, equally divided into three groups, were purposely recruited via email and WhatsApp messages for semi-structured interviews using a smartphone …

Cefiderocol Heteroresistance Associated With Mutations In Tonb-Dependent Receptor Genes In Pseudomonas Aeruginosa Of Clinical Origin, Stephanie L Egge, Samie A Rizvi, Shelby R Simar, Manuel Alcalde, Jose R W Martinez, Blake M Hanson, An Q Dinh, Rodrigo P Baptista, Truc T Tran, Samuel A Shelburne, Jose M Munita, Cesar A Arias, Morgan Hakki, William R Miller

Faculty, Staff and Student Publications

The siderophore-cephalosporin cefiderocol (FDC) presents a promising treatment option for carbapenem-resistant (CR) P. aeruginosa (PA). FDC circumvents traditional porin and efflux-mediated resistance by utilizing TonB-dependent receptors (TBDRs) to access the periplasmic space. Emerging FDC resistance has been associated with loss of function mutations within TBDR genes or the regulatory genes controlling TBDR expression. Further, difficulties with antimicrobial susceptibility testing (AST) and unexpected negative clinical treatment outcomes have prompted concerns for heteroresistance, where a single lineage isolate contains resistant subpopulations not detectable by standard AST. This study aimed to evaluate the prevalence of TBDR mutations among clinical isolates of P. aeruginosa …

Modern Building Structures Are A Landscape-Level Driver Of Bat–Human Exposure Risk In Kenya, Tamika Lunn, Reilly T. Jackson, Paul W. Webala, Joseph G. Ogola, Kristian M. Forbes

Biological Sciences Faculty Publications and Presentations

Identifying the locations and drivers of high-risk interfaces between humans and wildlife is crucial for managing zoonotic disease risk. We suggest that continent-wide improvements to residential housing in Africa are inadvertently creating artificial roosting habitat for synanthropic free-tailed bats (family Molossidae), and that improved buildings are a rapidly accelerating exposure interface that needs urgent research attention and investment. Along a residential gradient in rural southern Kenya, we mapped building use by free-tailed bats in 1109 buildings. We show that bats often roost in human-occupied buildings, with almost one-in-ten buildings exhibiting evidence of bat occupation (9.2%) and one-in-13 found to contain …

Cellular And Molecular Basis Of Cd4+ T Cell Help At The Effector Phase During Immunotherapy Of Mhc-Ii Negative Tumors, Samuel Oche Ameh

Arts & Sciences Graduate Student Theses and Dissertations

Immune checkpoint therapies (ICT) have shown promise in treating solid tumors, providing cures and durable protection in some cases. However, only a subset of patients benefits from ICT, indicating a need for a deeper understanding of the requirements for successful therapy. In both mice and humans, αβ T cells are key mediators of spontaneous and ICT-induced anti-tumor responses. While the anti-tumor roles of CD8+ T cells are well-studied, the role of CD4+ T cells, particularly in ICT for MHC-II negative tumors, is less understood. New insights into how CD4+ T cells modulate CD8+ T cells during ICT may lead to …

Bispecific Antibodies And Autologous Chimeric Antigen Receptor T Cell Therapies For Treatment Of Hematological Malignancies, Samer Al Hadidi, Helen E Heslop, Malcolm K Brenner, Masataka Suzuki

Faculty, Staff and Students Publications

In recent years, the therapeutic landscape for hematological malignancies has markedly advanced, particularly since the inaugural approval of autologous chimeric antigen receptor T cell (CAR-T) therapy in 2017 for relapsed/refractory acute lymphoblastic leukemia (ALL). Autologous CAR-T therapy involves the genetic modification of a patient's T cells to specifically identify and attack cancer cells, while bispecific antibodies (BsAbs) function by binding to both cancer cells and immune cells simultaneously, thereby triggering an immune response against the tumor. The subsequent approval of various CAR-T therapies and BsAbs have revolutionized the treatment of multiple hematological malignancies, highlighting high response rates and a subset …