Digital Commons Network^™

The Complexity And Significance Of Fibroblast Growth Factor (Fgf) Signaling For Fgf-Targeted Cancer Therapies, Anh Nguyen, Caroline Facey, Bruce Boman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Fibroblast growth factors (FGFs) have diverse functions in the regulation of cell proliferation and differentiation in development, tissue maintenance, wound repair, and angiogenesis. The goal of this review paper is to (i) deliberate on the role of FGFs and FGF receptors (FGFRs) in different cancers, (ii) present advances in FGF-targeted cancer therapies, and (iii) explore cell signaling mechanisms that explain how FGF expression becomes dysregulated during cancer development. FGF is often mutated and overexpressed in cancer and the different FGF and FGFR isoforms have unique expression patterns and distinct roles in different cancers. Among the FGF members, the FGF 15/19 …

Effectiveness Of Using Soft Exosuit In Stroke Case To Improve Walking Speed And Endurance, Aditya Denny Pratama, Rakha Shidqi Widyadhana

Jurnal Fisioterapi Terapan Indonesia

Stroke is a clinically defined syndrome of acute, focal nerve discharge caused by vascular injury (infarction, hemorrhage) of the central nervous system. Punches can cause damage to the brain and affect a person's ability to walk, balance and coordinate movements. Impaired gait is common in stroke cases, often resulting in poor recovery of mobility and inability to carry out daily activities without assistance. One of the interventions that can be used is a soft exosuit. This method can help overcome walking problems in stroke patients where soft exosuits are used to increase walking speed and walking endurance. The purpose of …

A Comprehensive Usability And Economic Analysis Of Heat-Related Wearable Technologies: Applications To Occupational Health, Ryan T. Cannady

Theses & Dissertations

The purpose of this research was to analyze the usability and economic considerations of real-time wearable technologies that are implemented in occupational settings to assess risk of heat stress and heat strain. The study population included current agriculture workers and Department of Energy (DOE), Environmental Management (EM) contractors. We employed a mixed-methods approach to comprehensively analyze the usability and economic considerations of heat-related technologies. Specifically, our approach assessed three distinct aspects the applications of these technologies in occupational settings to comprehensively address our research objective: (1) worker perceptions of heat-related wearable technologies, (2) field-based assessment of these heat-related wearable technologies, …

Brain Text And Traumatic Postmemory In Jonathan Safran Foer's Extremely Loud And Incredibly Close, Ercong Gao, Junwu Tian

Kritika Kultura

By adopting Nie Zhenzhao’s conception of brain text, this paper explicates the generation of traumatic postmemories as represented in Extremely Loud and Incredibly Close by Jonathan Safran Foer, a third-generation descendant of Holocaust witnesses. The authors argue that the traumatic effects of great catastrophic events, such as the Holocaust during the Second World War and the 9/11 terrorist attacks in 2001, can be transformed into brain texts of horror and trauma of the survivors, which, with time passing by, become the traumatic postmemories of the survivors’ descendants who have not experienced these events. As far as this novel is concerned, …

Investigation Into The Effect Of Aspartame On The Expression Of P53 And Bax In Mouse Stomach Tissue, Angelique Cheryl, Aoife Mac Cooey

SURE Journal: Science Undergraduate Research Experience Journal

Introduction: The recent reclassification of aspartame as a Group 2B hazard by the International Agency for Research on Cancer, along with studies suggesting links to cancer, has raised concerns and prompted further investigation. Evidence suggests that aspartame exposure may alter p53 and BAX gene expression, affecting apoptosis in cancer cells. This study aims to examine how aspartame exposure affects p53 and BAX gene expression in normal mouse stomach tissue, shedding light on cellular stress and apoptosis mechanisms.

Methods: Mice were sacrificed, and stomach tissue was excised and divided into control and treatment groups. RNA extraction was carried out in the …

Music Is My Language: Analyzing Autism Acceptance Within Communities, Cielo Bake

Undergraduate Honors Theses

This thesis explores the intersection of music and romanticism, drawing upon the emotional expressionism of Romantic era composers, inspired by Romantic literature, such as Frederic Chopin and Franz Liszt as a vehicle for communication. The ultimate goal was to determine a way to bridge the neurodivergent and neurotypical gaps in connection, enabling a stronger community that values every member of its locale and allows for a sense of belonging. The format for this research is through a performance, comprised of a piano recital of Romantic Era music by Frederic Chopin and Franz Liszt and improvised original music with a speech. …

Perceptions And Attitudes Of Western Michigan University Students On Antibiotic Medications, Emily Boask

Honors Theses

On a global scale, antibiotic resistance is a threat to public health. The causes of antibiotic resistance are multifaceted, including healthcare providers overprescribing antibiotics, antibiotic overuse in farming and food production, and antibiotic misuse or malpractices. The public recognizes antibiotic resistance as a significant problem but there are serious knowledge gaps regarding antibiotic resistance and antibiotic stewardship.

University students are a particularly important subpopulation of the public to understand appropriate antibiotic use because many of these individuals are navigating their health concerns on their own for the first time. Many individuals believe that antibiotics can improve cold symptoms, upper respiratory …

December 4, 2024 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Deliberate Cold Exposure As Augmentation For Diabetic Management, Joel Graham, Michael Graham, Patrick Clyde, Michael Racine, Jason Brumitt

Doctor of Medical Science (DMSc)

CE has received attention during the past decade as a modality to decrease inflammation, improve mood, increase mental resiliency, and to facilitate physical exercise recovery. This “treatment” has been in use for centuries having been mentioned in ancient Greek texts. CE is also a common cultural practice of Nordic countries, with its traditional uses centering on the therapeutic effects improved health and recovery. These effects are predominantly moderated through the activation of the sympathetic nervous system (SNS) by changes in skin temperature, which subsequently induces the release of catecholamines to conserve body heat and prevent the onset of hypothermia. The …

(R2111) Effect Of Stenotic-Aneurysmal Arterial Regime On Unsteady Magnetohydrodynamic Non-Newtonian Blood Flow With Heat Radiation, Babatunde A. Joseph, Dada M. Sunday, Bello A.J. Funsho, Akeem B. Disu, Alamu-Awoniran F., Danas James Y.

Applications and Applied Mathematics: An International Journal (AAM)

The study aims to investigate the effect of magneto-hydrodynamic on a non-Newtonian unsteady blood flow with internal heat energy in the presence of blood ironic properties characterized by stenosis. The formulated mathematical equations resulted in differential forms and were solved analytically by Differential Transform Method. The obtained solutions were displayed by graphs showing different flow physiognomies like blood velocity, temperature profile, Nusselt number, wall shear stress and stream function.

The results indicated that velocity profile increases as magnetic field, Darcy number and aneurysmal artery rise, while it decreases as heat radiation, Reynold number, and Casson parameter speedup. The temperature profile …

The Mutant Mouse Resource And Research Center (Mmrrc) Consortium: The Us-Based Public Mouse Repository System., Yuksel Agca, James Amos-Landgraf, Renee Araiza, Jennifer Brennan, Charisse Carlson, Dominic Ciavatta, Dave Clary, Craig Franklin, Ian Korf, Cathleen Lutz, Terry Magnuson, Fernando Pardo-Manuel De Villena, Oleg Mirochnitchenko, Samit Patel, Dan Port, Laura G Reinholdt, K C Kent Lloyd

Faculty Research 2024

Now in its 25th year, the Mutant Mouse Resource and Research Center (MMRRC) consortium continues to serve the United States and international biomedical scientific community as a public repository and distribution archive of laboratory mouse models of human disease for research. Supported by the National Institutes of Health (NIH), the MMRRC consists of 4 regionally distributed and dedicated vivaria, offices, and specialized laboratory facilities and an Informatics Coordination and Service Center (ICSC). The overarching purpose of the MMRRC is to facilitate groundbreaking biomedical research by offering an extensive repertoire of mutant mice that are essential for advancing the understanding of …

Exploring The Interactive Effects Of Officer, Subject, And Encounter Factors On Police Use Of Force Outcomes, Jeremy David Barnum

UNLV Theses, Dissertations, Professional Papers, and Capstones

Police use of force incidents are highly complex events that can be characterized by factors pertaining to the officers, subjects, and immediate encounter. These factors and the dynamic interrelationships between them encompass the situational context of use of force and have been widely studied in the criminological literature (Bolger, 2015). However, extant research has almost exclusively focused on identifying the main effects of situational factors on use of force with little consideration of how effects may vary across specific situational contexts. This limits our understanding of police use of force and complicates efforts to develop policy or training that ensures …

Feasibility Study On Microwave Glucose Level Monitoring, Ricardo Cepeda

Theses and Dissertations

Diabetes management heavily relies on regular blood glucose monitoring, which traditionally involves invasive techniques. In recent years, significant research has been directed towards developing non-invasive glucose monitoring methods, particularly using electromagnetic waves. This study explores the feasibility of detecting blood glucose levels non-invasively by measuring the resonant frequency shifts of an antenna, influenced by the dielectric properties of blood. Microwave measurement techniques have garnered attention due to their ability to safely penetrate human tissue and detect biochemical markers like glucose. While previous studies have established a link between glucose concentration and dielectric properties, many techniques suffer from poor sensitivity or …

Demonstrating Feasibility Of Ultrasound-Sensitive Microbubbles Delivery To Treat Disruptions In The Blood Brain Barrier Endothelium, Rubens Jourdain

Theses and Dissertations

Vascular cognitive impairment and dementia (VCID) is one of the main causes of dementia. VCID is caused by age and other genetic factors that lead to disruptions in the blood brain barrier (BBB) and allow blood components to enter the brain. The currently available treatments of VCID include opening the BBB with high-frequency-ultrasound to deliver drugs to the brain. However, this only treats the already developed disease. Consequently, we developed a new drug delivery system whose goal is to restore the brain capillary endothelial cells (BCEC) lining the blood vessel. The objective of this study was to demonstrate the feasibility …

The Effects Of Multiple Acute Turkesterone Doses On Indirect Measures Of Hypertrophy And Metabolic Measures: A Preliminary Investigation, Dillon R. Harris, Tomas Chapman-Lopez, Steven B. Machek, Jeffery S. Forsse, Tracey Sulak, Leslee K. Funderburk

Kinesiology Faculty Publications and Presentations

Turkesterone is a naturally occurring plant steroid touted for its medicinal, pharmacological, and biological properties with no reported adverse side effects compared with traditional anabolic androgenic steroids (AAS). However, this ostensible enhancement to increase muscle protein synthesis and facilitate augmented thermogenesis remains undescribed despite uninformed and potentially haphazard consumption. To investigate whether turkesterone enhances insulin-like growth factor-1 (IGF-1) and resting metabolic rate (RMR), eleven apparently healthy males (23.3 ± 2.2) volunteered to participate in the present study with samples collected pre-, 3H post-, and 24H post-ingestion. Subsequent analyses failed to reveal any significant main condition, time, or interaction main effects …

Study Of Temperature Effects Of Glucose And Microwave Dielectric Dispersion Model, Ethan Grant Boone

Theses and Dissertations

In this study, the temperature effect of dielectric properties in various aqueous solutions containing glucose are examined. A design for a new testing chamber is introduced to provide improved conditions for testing to ensure accurate and precise measurements. A N-SMA Adaptor is used when obtaining dielectric characteristics of glucose solutions ranging 100-300mg/dl. Dielectric parameters are obtained adopting a modified Debye dispersion model. MATLAB is used to confirm coaxial dimensions are suitable fabrication designs using fixed dielectric parameters of air and water. Simulations and design models were implemented utilizing ANSYS High Frequency Structure Simulator and 3-D Modeler software to develop the …

Testosterone Acts Through The Membrane Protein Gprc6a To Cause Cardiac Edema In Zebrafish Embryos, Vahid Zadmajid, Shayan Shahriar, Daniel A Gorelick

Faculty, Staff and Students Publications

Androgens are classically thought to act through intracellular androgen receptors (AR/NR3C4), but they can also trigger non-genomic effects via membrane proteins. Although several membrane androgen receptors have been characterized in vitro, their functions in vivo remain unclear. Using a chemical-genetic screen in zebrafish, we found that GPRC6A, a G-protein-coupled receptor, mediates non-genomic androgen actions during embryonic development. Exposure to androgens (androstanedione, DHT and testosterone) caused cardiac edema or tail curvature in wild-type embryos, as well as in ar mutants, suggesting AR-independent pathways. We then mutated putative membrane androgen receptors [gprc6a, hcar1-4 and zip9 (slc39a9)] and found that only gprc6a mutants …

How To Love In Easy Steps: Heteronormativity, Queer Love, And Foucault's Counter-Conduct, Hannah Jane S. Carpiso, Ninotchka Mumtaj B. Albano

Budhi: A Journal of Ideas and Culture

Love is one of the most pervasive human experiences, yet its definition remains elusive to this day. Attempts to describe love have led to the institutionalization and privileging of heterosexual identities, relationships, and ways of loving. Michael Warner refers to this phenomenon as “heteronormativity,” which rigidifies subjectivities and relationalities into fixed, heterosexist structures. However, queer love unfolds in ways different from this relational structure. It invents and re-invents love, relationalities, and subjectivities by moving beyond the dichotomies of heteronormativity. The inventive characteristic of queer love is found in what is known as the “gay mode of life,” an instance of …

Nutrition Recommendations For Patients On Weight Loss Drugs, Crystal M. Duque Rdn-Ldn, Toye Jackman

Department of Nutrition Student Projects

This paper provides a comprehensive, evidence-based framework for dietitians counseling patients who are using GLP-1 receptor agonists, such as Ozempic and Wegovy, for weight management. These medications are rapidly gaining popularity for their effectiveness in supporting weight loss; however, they come with unique nutritional considerations that require tailored guidance. This review outlines key aspects of GLP-1 mechanisms of action, emphasizing how these medications alter digestive processes, specifically impacting the absorption and metabolism of essential macronutrients, including proteins and dietary fibers. The paper also highlights hydration needs to support optimal health and weight loss outcomes in patients on GLP-1 therapies. Additionally, …

Roles Of The Gut Microbiota In Human Neurodevelopment And Adult Brain Disorders, Rahul Mallick, Sanjay Basak, Ranjit Kumar Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

Health & Biomedical Sciences Faculty Publications

Growing evidence demonstrates the connection between gut microbiota, neurodevelopment, and adult brain function. Microbial colonization occurs before the maturation of neural systems and its association with brain development. The early microbiome interactions with the gut-brain axis evolved to stimulate cognitive activities. Gut dysbiosis can lead to impaired brain development, growth, and function. Docosahexaenoic acid (DHA) is critically required for brain structure and function, modulates gut microbiota, and impacts brain activity. This review explores how gut microbiota influences early brain development and adult functions, encompassing the modulation of neurotransmitter activity, neuroinflammation, and blood-brain barrier integrity. In addition, it highlights processes of …

The Echo: November 18, 2024, Taylor University

2024-2025 (Volume 112)

No abstract provided.

Mitochondrial Pyruvate Transport Regulates Presynaptic Metabolism And Neurotransmission, Anupama Tiwari, Jongyun Myeong, Arsalan Hashemiaghdam, Marion I Stunault, Hao Zhang, Xiangfeng Niu, Marissa A Laramie, Jasmin Sponagel, Leah P Shriver, Gary J Patti, Vitaly A Klyachko, Ghazaleh Ashrafi

2020-Current year OA Pubs

Glucose has long been considered the primary fuel source for the brain. However, glucose levels fluctuate in the brain during sleep or circuit activity, posing major metabolic stress. Here, we demonstrate that the mammalian brain uses pyruvate as a fuel source, and pyruvate can support neuronal viability in the absence of glucose. Nerve terminals are sites of metabolic vulnerability, and we show that mitochondrial pyruvate uptake is a critical step in oxidative ATP production in hippocampal terminals. We find that the mitochondrial pyruvate carrier is post-translationally modified by lysine acetylation, which, in turn, modulates mitochondrial pyruvate uptake. Our data reveal …

Appendix 1: College Of Medicine Departmental Synoptic Histories, J. G. Reves

MUSC Faculty Bookshelf

This is a multi-contributor compilation of the histories of all the academic departments in the College of Medicine. It was edited by Philippa Newfield, MD, and J.G. Reves, MD. Each department in the College of Medicine has a history and the histories are told primarily by the chairs of the departments.

Investigating The Impact Of Ssris On Cardiovascular Risk Factors In Young Healthy Individuals: A Preliminary Study, Elena S. Shostak, Jillian M. Lang, William Quinn, Valerie Chervinskaya, Elisa Fioraso, Everett Smith, Christopher J. Kotarsky, Justin A. Deblauw, Jennifer Lloyd, Stephen J. Ives

International Journal of Exercise Science: Conference Proceedings

Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants that are commonly used to treat anxiety, depression, and other psychological disorders. The effects of SSRIs on cardiometabolic health in young and healthy populations have not been well described. PURPOSE: We evaluated the effects of SSRI useon blood pressure (BP), heart rate variability (HRV), arterial stiffness, and microvascular function, of young, otherwise healthy adults. METHODS: Fourteen healthy males and females aged 18-41 were included in this study, separated by use of SSRIs, and matched into pairs based on sex, age, height, and weight. Anthropometrics, BP, arterial stiffness, HRV, …

Acute Impacts Of A Novel Proprietary Supplement Blend On Aerobically-Focused Outcomes In Trained Crossfit Athletes: A Preliminary Analysis, Ashley Holland, Evan Hedrick, Jason Michael Cholewa, Steven Machek

International Journal of Exercise Science: Conference Proceedings

CrossFit is a high-intensity sport that requires high cardiovascular fitness but aerobically-focused supplements are sparsely investigated within this demographic PURPOSE: to examine the efficacy of a novel ergogenic supplement blend on various cardiovascular metrics in CrossFit athletes. METHODS: 11 trained CrossFit athletes (30±6y; 3M/8F) were recruited for this acute, placebo-controlled study, whereby participants visited the laboratory on a single day to assess baseline resting heart rate (RHR), blood pressure (BP), and fingertip lactate (LAC) immediately prior to being randomly assigned to ingest either 4ml of a proprietary supplement blend (SUP; containing Beetroot, Ashwagandha, Arjuna, Rhodiola, and Cayenne) …

Born High, Born Fast: Does Highland Birth Confer A Pulmonary Advantage For Sea Level Endurance?, Hunter L. Paris, Marissa N. Baranauskas, Keren Constantini, Ren Jay Shei, Peyton E. Allen, John R. Jadovitz, Chad C. Wiggins, Cooker Perkins Storm

All Faculty Open Access Publications

Less than 7% of the world's population live at an altitude above 1500 m. Yet, as many as 67% of medalists in the 2020 men's and women's Olympic marathon, and 100% of medalists in the 2020 men's and women's Olympic 5000 m track race may have been born or raised above this otherwise rare threshold. As a possible explanation, research spanning nearly a quarter of a century demonstrates that indigenous highlanders exhibit pulmonary adaptations distinct from their lowland counterparts. These adaptations may then promote endurance performance. Indeed, healthy indigenous highlanders often exhibit a larger aerobic exercise capacity compared to sea-level …

Artificial Gravity: An Effective Countermeasure For Microgravity-Induced Headward Fluid Shift?, Larry A Kramer, Khader M Hasan, Xu Zhang, Edwin Mulder, Darius A Gerlach, Karina Marshall-Goebel, Brandon R Macias, Steven S Laurie, Gary Strangman, Raj Iyer, Eric M Bershad

Faculty, Staff and Student Publications

Long-duration spaceflight is associated with pathophysiological changes in the intracranial compartment hypothetically linked to microgravity-induced headward fluid shift. This study aimed to determine whether daily artificial gravity (AG) sessions can mitigate these effects, supporting its application as a countermeasure to spaceflight. Twenty-four healthy adult volunteers (16 men) were exposed to 60 days of 6° head-down tilt bed rest (HDTBR) as a ground-based analog of chronic headward fluid shift. Subjects were divided equally into three groups: no AG (control), daily 30-min intermittent AG (iAG), and daily 30-min continuous (cAG). Internal carotid artery (ICA) stroke volume (ICASV), ICA resistive index (ICARI), ICA …

Therapeutic Targeting Of Hypoxia Inducible Factor In Acute Respiratory Distress Syndrome, Thu T Tran, Holger K Eltzschig, Xiaoyi Yuan

Faculty, Staff and Student Publications

Acute respiratory distress syndrome (ARDS) is characterized by bilateral chest infiltration and acute hypoxic respiratory failure. ARDS carries significant morbidity and mortality despite advancements in medical management, calling for the development of novel therapeutic targets. Hypoxia-inducible factor (HIF) is a heterodimeric protein involved in various essential pathways, including metabolic reprogramming, immune modulation, angiogenesis and cell cycle regulation. HIF is routinely degraded in homeostasis conditions via the prolyl hydroxylase domain/von Hippel-Lindau protein pathway. However, HIF is stabilized in ARDS via various mechanisms (oxygen-dependent and independent) as an endogenous protective pathway and plays multifaceted roles in different cell populations. This review focuses …

Stressfit: A Hybrid Wearable Physicochemical Sensor Suite For Simultaneously Measuring Electromyogram And Sweat Cortisol, Nafize Ishtiaque Hossain, Tanzila Noushin, Shawana Tabassum

Electrical Engineering Faculty Publications and Presentations

This study introduces StressFit, a novel hybrid wearable sensor system designed to simultaneously monitor electromyogram (EMG) signals and sweat cortisol levels. Our approach involves the development of a noninvasive skin patch capable of monitoring skin temperature, sweat pH, cortisol levels, and corresponding EMG signals using a combination of physical and electrochemical sensors integrated with EMG electrodes. StressFit was optimized by enhancing sensor output and mechanical resilience for practical application on curved body surfaces, ensuring accurate acquisition of cortisol, pH, body temperature, and EMG data without sensor interference. In addition, we integrated an onboard data processing unit with Internet of Things …

University Of Dayton Roadmap To The Mcat: Tracking Mcat Content In Your Natural And Behavioral Science Courses, University Of Dayton

Pre-Health Resource Center Campus Communications

No abstract provided.