Digital Commons Network^™

Long-Term Survival Follow-Up For Tebentafusp In Previously Treated Metastatic Uveal Melanoma, Joseph Sacco, Richard Carvajal, Marcus Butler, Alexander N Shoushtari, Jessica Hassel, Alexandra Ikeguchi, Leonel Hernandez-Aya, Paul Nathan, Omid Hamid, Josep Piulats, Matthew Rioth, Douglas B Johnson, Jason Luke, Enrique Espinosa, Serge Leyvraz, Laura Collins, Chris Holland, Takami Sato

Kimmel Cancer Center Faculty Papers

BACKGROUND: Tebentafusp, a bispecific (gp100×CD3) ImmTAC, significantly improved overall survival (OS) outcomes for HLA-A*02:01+ adult patients with untreated metastatic uveal melanoma (mUM) and showed promising survival in previously treated mUM with 1-year OS of 62% in the primary analysis of study IMCgp100-102. Here we report long-term outcomes from this phase 1/2 study in pretreated mUM.

PATIENTS AND METHODS: Patients with previously treated mUM received tebentafusp weekly intravenous at 20 µg dose 1, 30 µg dose 2 and either 54, 64, 68, or 73 µg (phase 1) or 68 µg (phase 2) dose 3+. The primary objective was overall response rate. …

Romani American History: Historical Absences And Their Consequences, Ann Ostendorf

History Faculty Scholarship

American historians have created an historical absence by ignoring Romani people’s presence in evidence from the past. The origins of this “absence-ing” are multifaceted and interrelated, but fundamentally stem from the continued influence of out-of-date and unprofessional ways of thinking and knowing. Examining and understanding “absence-ing” requires a consideration of the nature of the discipline of history as well as a history of the missing historicization of Romani Americans. The consequences of the “absence-ing” of Romani people from American histories have negatively and distinctively influenced four different groups of people: historians of the Americas; historians of Romani people in Europe; …

Yang-Baxter Equations, David Lovitz

Dissertations and Theses

Multiple equations in math, physics, quantum information, and elsewhere are referred to as "the" Yang-Baxter equation, in spite of being a broad family of equations. Most of the equations are nonlinear matrix equations, where the unknown variable is a matrix. This is the case for the so called braided, algebraic, and generalized forms of "the" equation, which are the primary focus of this dissertation. Finding solutions to the various forms of these equations has been the subject of much research. The equations in all their forms are largely considered intractable in high dimensions, and only in dimension 2 have the …

Characterizing The Role Of The Complement Receptor C3ar In Regulating Inflammatory Responses And Mitochondrial Function In Activated Macrophages, Jesse Alan Corcoran

Dissertations and Theses

The complement system is an integral part of the innate immune response, and consists of a series of proteins that are mostly (although not exclusively) synthesized in the liver that circulate in the plasma as inactive precursors, as well as receptors on the surface of immune cells. In immune cells such as macrophages, recognition of pathogens by Toll-like receptors (TLRs) leads to the initiation of inflammation and triggers complement activation through a coordinated sequential enzyme cascade that results in the production of bioactive C3a, which interacts with membrane-bound receptor C3aR to regulate innate immune cell function and outcome of bacterial …

Naming And Interpretative Meanings Of Selected African Prints And Ankara Fabric Designs, Adeola Abiodun Adeoti

Journal of Art, Design and Music

Ankara fabric has colourful designs, but both the colours and the designs on the fabric have hidden meanings with proverbs and events attached to them. As much as the fact that the paper is art historical, the naming system of Ankara fabric is yet to attract scholarly interest. Therefore, the ephemerality of the fabric and the changing nature of fashion call for immediate and chronological record of the histories of the designs before it fades out of memory. The study adopts qualitative approach of analyzing data with the use of both primary and secondary sources of data collection which were …

Towards Understanding The Post-Colonial In The Development Of Irish Economics, Joseph K. Fitzgerald Dr., Brendan K. O'Rourke

Conference Papers

This conference contribution is prompted by recent work where theories used to understand the economists in countries like France, Britain, Germany, and the USA (Fourcade, 2009; Maesse, 2015) were used to study the development of Irish economics profession. Work on Ireland (FitzGerald & O’Rourke, 2023), though using these frameworks, revealed the importance of Ireland’s colonial and post-colonial experiences in the social status of economics in today’s Ireland. Escobar (2011) points to the power of economists in development discourses focussing particularly on the case of Columbia and the interaction between USA economics with its southern neighbours in the period since the …

Class And Class Consciousness According To E. P. Thompson, Daniel Cunningham

Philosophy Faculty Publications

In this article, I extract a theory of class from E. P. Thompson’s historical works of the 1960s and 1970s, focusing especially on his 1963 magnum opus The Making of the English Working Class, the articles later collected in the 1991 volume Customs in Common: Studies in Traditional Popular Culture, and the essays “The Peculiarities of the English” and “Eighteenth-Century English Society: Class Struggle without Class?” In the first section, I argue, following Ellen Meiksins Wood, that Thompson developed a genuinely historical materialist theory of class formation as a “structured process” that moves from class struggle to class …

Metric Schemas And Projections In Three Colombian Folk Genres, Lina S. Tabak

Dissertations, Theses, and Capstone Projects

This dissertation explores how stylistic expertise can affect metric perception, through the analysis of three Colombian folk genres—cantos de boga and currulaos from the Pacific region and joropos from the Eastern plains bordering Venezuela. Specifically, it considers the tension between metric perceptions which arise from bottom-up mechanisms for entrainment (such as projections), and those which are based on top-down mechanisms (such as schemata). This tension is at play when more and less musically enculturated listeners perceive entirely different metric structures when listening to identical music.

Taking bottom-up and top-down metric perception as a thread, this dissertation isolates three additional metric …

"Crush The Monster": Homosexuality And Moral Panic In 1950s Idaho, Ian Hadrick

University Honors Theses

On October 31, 1955, three men were arrested and accused of performing homosexual acts in the quiet, suburban community of Boise, Idaho. The arrests set off a sweeping investigation of Boise's "widespread homosexual underground" that made national news and resulted in more than one thousand police interrogations and the conviction of fifteen homosexual Boiseans. Though Boise's moral panic and the ensuing investigation are among the largest of the sex panics of the 1950s, the city's 1955 homosexuality scandal has attracted relatively little scholarly attention. An in-depth analysis of the social, economic, and political forces that combined to produce hysteria in …

Mendelian Segregation And High Recombination Rates Facilitate Genetic Analyses In Cryptosporidium Parvum, Abigail Kimball, Lisa Funkhouser-Jones, Wanyi Huang, Rui Xu, William H. Witola, L. David Sibley

2020-Current year OA Pubs

Very little is known about the process of meiosis in the apicomplexan parasite Cryptosporidium despite the essentiality of sex in its life cycle. Most cell lines only support asexual growth of Cryptosporidium parvum (C. parvum), but stem cell derived intestinal epithelial cells grown under air-liquid interface (ALI) conditions support the sexual cycle. To examine chromosomal dynamics during meiosis in C. parvum, we generated two transgenic lines of parasites that were fluorescently tagged with mCherry or GFP on chromosomes 1 or 5, respectively. Infection of ALI cultures or Ifngr1-/- mice with mCherry and GFP parasites resulted in cross-fertilization and the formation …

Connecting The Dots: Sharing Hidden Histories Of Regional Inventors’ Patents, John Schlipp, Kris Kallies

Journal of the Patent and Trademark Resource Center Association

Patent and Trademark Resource Centers (PTRCs) support inventors, entrepreneurs, and researchers with patent and trademark information. Some PTRCs share regional patent history as part of their community outreach. This article focuses on PTRCs that have developed online databases and published works documenting regional patents, thereby providing hidden historical insights for historians, genealogists, and students. It spotlights the development of Georgiavation, a historic patent database developed by the PTRC at Georgia Southern University. Finally, this article offers guidance for libraries, museums, and other institutions interested in documenting their state or regional patent histories. This can result in a more inclusive narrative …

Time Ripens On The Counter: A Literary History Of The Americas, Judah Rubin

Dissertations, Theses, and Capstone Projects

The tumultuous years of the 1970s and 1980s are generally seen as marking the ends of the New Left in the United States and the Americas at large. With shifts afoot in US policy that would see the drawdown and close of the Vietnam War, increased subversion and infiltration of Left-wing movements, these decades are often remembered as a holding pattern and, later, nadir in progressive, not to mention revolutionary, gains. The same was true, if not amplified, across the Americas where, tens of thousands were murdered, imprisoned and disappeared across the Southern Cone and into the Andes, and where …

The Pursuit Of Productivity: A Marxist Analysis Of How Frederick Winslow Taylor And Dr. W. Irving Clark Revolutionized The American Factory During The Early Twentieth Century, Stephen Hood

University Honors Theses

In 1911, two events occurred that laid the framework for a revolution in factory management; Frederick Winslow Taylor published his famous work The Principles of Scientific Management; and The Norton Emery Company hired W. Irving Clark to open a first-of-its-kind medical facility. Clark's work should be understood as an extension of the scientific management that Taylor championed during the turn of the twentieth century. The factory served as a laboratory for men like Clark and Taylor to create new methods for increasing productivity while attempting to overcome contradictions inherent to the capitalist mode of production. By utilizing the work …

Abusive Abbots And Malevolent Monks: Monasteries And Violence In The Early Anglo-Norman Period, Timothy B. Smart Jr.

University Honors Theses

This investigation examines the conduct of abbots and monasteries from 1066 to 1087 in the context of violence and monasteries. It analyzes monastic chronicles and Anglo-Norman histories. The two historiographical lineages that emerge: the Norman Conquest and religious warfare. After the initial conquest in 1066, four native abbots offer insight into a range of local monastic behaviors during the early years of Norman rule. The Normans, in their combat against rebellious monasteries, developed procedures to remove local abbots in 1070. This connection between rebellions and monasteries drove the militarization of monasteries by both the Normans and the Anglo-Saxons. The militarization …

Language And The Lord Of The Rings: The Expansion Of A Universe, Thomas Beutz

The Criterion

Tommy Beutz’s essay, “Language and The Lord of the Rings: The Expansion of a Universe” explores J.R.R. Tolkien’s world-building through the lens of linguistics. Beutz argues that Tolkien’s creation of Middle-Earth, anchored in his invented languages, extends beyond the bounds of the text. Drawing on Tolkien’s background as a philologist, Beutz contends that the languages of Middle-Earth are not mere literary devices but rather the foundation of its entire mythology. By examining linguistic markers embedded in the primary text, Beutz reveals how Tolkien hints at a larger world outside the narrative. Through an analysis of historical accounts and characters’ …

“My Kingdom For A Horse!” The Development Of Equestrian Influence In Early Modern Europe, Jane Goode

Bound Away: The Liberty Journal of History

Humanity has always had a close relationship with horses, from using them for work to warfare to recreation. The era of early modern Europe is especially telling because of the transition of horsemanship underwent during that period. The horse has been used as a symbol of status and power that can be seen strongly throughout the culture of the 17th and 18th centuries with the development in breeding, the impact on different courts throughout Europe, and their elevation in art.

Lost But Not Found: Southern Appalachia, Migration Patterns, And Culinary Tourism, Ashli Q. Stokes, Wendy Atkins-Sayre

Dublin Gastronomy Symposium

Despite growing acknowledgement of the variety of cultures that developed Southern Appalachia’s cuisine, some popular food writing continues to highlight the so-called insular nature of its food, drink, and culinary festivals. Regional tourists, especially those visiting its Blue Ridge or Smoky mountains, also remain likely to experience a delimited, often problematic Scots-Irish or white-European pioneer past, including when they eat and drink. Billboards advertise the outlaw Hatfield and McCoy Dinner Show, visitors choose from moonshine tastings in dilapidated looking but new distilleries, and diners enjoy gourmet biscuits alongside gravy “flights” at trendy restaurants in Asheville, North Carolina. Appalachian Studies and …

“Praying And Eating”: The Preservation Of Jewish Food Traditions In The Wake Of Brexit Trauma, Angela Hanratty

Dublin Gastronomy Symposium

This research examines the impact that Brexit, the Northern Ireland Protocol, and the Windsor Framework have had on the food traditions of the Jewish population of Ireland, through focusing on the lived experience of the Jewish communities of Belfast and Dublin and their collective memory. While there has been much debate on the lasting effect of the UK leaving the EU on industry and agriculture, the deleterious impact on the kosher observant in Ireland has been less documented, with specific challenges for the preservation of food traditions in a community with a history “full of praying and eating” (Maurice Cohen, …

Methods To Manage Survey Error Within Economic Contribution Analysis, Madison Jane Plaisance

LSU Master's Theses

The primary objective of this research was to employ strategical methodological approaches to assess the economic value of specific sub-sectors of the green industry within Louisiana. I specifically focused on addressing errors associated with utilizing survey data as the primary data source in such analyses and utilizing approaches such as post-survey stratification and bootstrapping techniques to mitigate these errors.

To achieve this aim, a group of green industry professionals and I selected sectors for analysis based on horticultural licenses issued by the Louisiana Department of Agriculture and Forestry (LDAF). Through collaboration with advisors from the Louisiana Nursery and Landscape Association …

Youth Work For People And Planet: Integrating Insights From Ecopedagogy Into Youth Work, Trudi Cooper, Tim Corney, Jamie Gorman

Research outputs 2022 to 2026

Youth work is not unitary, has a diverse history, and draws upon differing traditions; however, the focus of all major youth work traditions has been anthropocentric. This approach is now challenged by young people themselves through the climate justice movement, and institutionally through the United Nations Agenda 2030 resolution, which has developed integrated Sustainable Development Goals, which aim to “balance” social, environmental, and economic imperatives. This article examines what insights can be gained from ecopedagogy that would enable youth work to fully integrate an ecological perspective alongside traditional anthropological concerns. The discussion focuses on the nexus and tensions between ecopedagogy …

Frequent Disturbances Enhanced The Resilience Of Past Human Populations, Philip Riris, Fabio Silva, Enrico Crema, Alessio Palmisano, Erick Robinson, Peter E. Siegel, Jennifer C. French, Erlend Kirkeng Jørgensen, Shira Yoshi Maezumi, Steinar Solheim, Jennifer Bates, Benjamin Davies, Yongje Oh, Xiaolin Ren

Department of Anthropology Faculty Scholarship and Creative Works

The record of past human adaptations provides crucial lessons for guiding responses to crises in the future^1–3. To date, there have been no systematic global comparisons of humans’ ability to absorb and recover from disturbances through time^4,5. Here we synthesized resilience across a broad sample of prehistoric population time–frequency data, spanning 30,000 years of human history. Cross-sectional and longitudinal analyses of population decline show that frequent disturbances enhance a population’s capacity to resist and recover from later downturns. Land-use patterns are important mediators of the strength of this positive association: farming and herding societies are more …

An Examination Of The Geographical And Archaeological Evidence Which Supports The Historical Reliability Of The Gospel Of John, Alan R. Peterson

Masters Theses

The question of the historical reliability of the New Testament is one of the central issues in Christian apologetics. This is an area that keeps agnostics and atheists from believing in the Bible and hence God. Few are willing to undertake an in-depth study to ferret out the truth; a simple Google internet search to confirm their secular presuppositions. For example, the top search result using Google for “historical reliability of gospel of John” brings up the following reply “The Gospel of John is a relatively late theological document containing little accurate historical information that is not found in the …

The Gothic Horror Tradition And Religious Sanctity: Terror And Faith In Midnight Mass (2021), Kalen Thomas Krantz

English Theses, Dissertations, and Student Creative Activity

Writer/director Mike Flanagan’s titular serial-television series, Midnight Mass (2021) created both critical controversy and acclaim. The television series, which aired on Netflix, employs elements of the Gothic tradition found in both literature and its later development in the film medium, especially that of the Gothic’s subgenre, horror, but its popularity is also reliant upon its originality, this resting largely on its combination of the horror genre with religious questions—ideas of the holy. Through a study of this series’ thematic and formal features, I show the vitality of the Gothic tradition by identifying elements in Midnight Mass that are either recognizably …

The Perpetual Progression In The Schleswig-Holstein Duchy: History, Politics, And Religion, 1460-1864, Christian Anthony Ahlers

Doctoral Dissertations and Projects

German nationalism in the Schleswig and Holstein duchies that predates the German Unification Wars of the Nineteenth Century continuously transformed in response to Danish encroachment, civic disputes regarding treaty legitimacy, and war. The Germans in the duchies fought to retain their ancestral homelands and, in doing so, embraced a pan-Germanic consciousness that is the foundation for early modern nationalism. This consciousness dates back hundreds of years. This case study examines the Germans of Schleswig and Holstein and their experiences with the consistent and pressing Danish encroachment. Despite the encroachment, the Germans remained connected with their culture, traditions, religion, and their …

The Book Of Ruth: Its Didactic Wisdom Themes, Brian Corn

Doctoral Dissertations and Projects

This dissertation proposes and argues that the Book of Ruth is better situated in Wisdom literature because of its didactic wisdom themes. Prominent wisdom themes will be analyzed and compared intertextually with the Book of Ruth, which provides Ruth’s understanding of YHWH. The research methodology evaluates the intertextuality, or inter-themes, between the Book of Ruth and the Wisdom literature (Job, Proverbs, and Ecclesiastes), the primary source. Peer-reviewed sources (scholarly commentaries, academic peer-reviewed journals, and scholarly biblical dictionaries) are used to evaluate and support the findings uncovered in the primary source. Semantic field and range studies are performed with the help …

The Impact Of Social Dance Skills On The Development Of Employee Soft Skills, Danielle May Patridge

Doctoral Dissertations and Projects

Employee soft skills are necessary in nearly every occupation for both employee and organizational success. There is a considerable body of knowledge related to the development of employee soft skills, and soft skills training is now seen in some educational curricula and organizational training programs. Yet, employers continue to report that employees and candidates are either lacking in or have underdeveloped soft skills, hampering both worker and organizational success. Soft skills cross domains and are not confined to use in the workplace; hence, they can also be developed in non-work domains. In this qualitative study, accomplished social dancers described their …

The Evidential Problem Of Assurance: Textual Approach From The Johannine Literature, Derick A. Adu

Doctoral Dissertations and Projects

Assurance of salvation is an existential issue that has occupied the center stage of theological deliberations in the Church's history. This dissertation is a quest for epistemic justification. The dissertation examines the conditions that justify and validate claims of assurance of salvation. The research is partly an epistemological quest as well as a textual inquiry. This study utilizes evidentialism, the epistemological concept that what provides epistemic justification is evidence, to reach a reasonable conclusion. The data for the analysis consists of the Johannine literature, that is, the Gospel of John, the three Epistles of John, and the book of Revelation. …

Christ’S Hallel And The Christian’S Hallelujah: A Comparative Analysis Of Jesus’ Last Supper Hymn With Contemporary Worship Songs, Maria Rica Silbol

Doctoral Dissertations and Projects

The Last Supper of Jesus Christ and his disciples is one of the most iconic events in Christendom. One of the fewer talked-about scenarios in this historical event is Matthew 26:30 and Mark 14:26, when Jesus and his disciples sang a hymn before his crucifixion. This study examines the Hallel or Psalms 113–118, which Bible scholars believe was the hymn that Jesus sang with his disciples. The primary themes and emphases of these psalms are identified and coded. The goal of this research is to provide a metric for how the teachings from the Hallel may serve as a reference …

The Stratified Leadership Model Of The First-Century Christian Church, Barton Schuyler Garratt Edsall Iv

Doctoral Dissertations and Projects

As Christianity enters its third millennium, it faces the sharpest decline in the number of people attending church congregations compared to the total population. In Romans 1:13, the Apostle Paul states that God’s people should not be ignorant that the purpose for leaders within the collective church body, beginning with himself as the example, is so the people’s lives would be fruitful–spiritually enriched and productive. Logic dictates that if the lives of those who attended Christian churches in the twenty-first century experienced and displayed such spiritual quality, attendance would not be declining but contrarily on the rise. Regarding church clergy …

Unitary Executive Theory, Audrey Espinosa

Political Analysis

Audrey Espinosa is a third year Political Science major in the 3+3 Law Program at Seton Hall University. She plans to pursue a career as a lawyer and is currently interested in researching constitutional and ideological politics. Her paper on the Unitary Executive Theory was inspired by the Constitutional Law class that she took in the Fall 2023 semester with Professor Pallitto. The topic was briefly covered in class texts and discussions, and she wanted to further explore the theory and argue against its principles with references to books, academic journals, and Supreme Court cases. She plans to pursue a …