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Investigation Of Campylobacter Concisus Gastric Epithelial Pathogenicity Using Ags Cells, Christopher Y. M. Luk, Seul A. Lee, Nicholas Naidovski, Fang Liu, Alfred C. Y. Tay, Liang Wang, Stephen Riordan, Li Zhang

Research outputs 2022 to 2026

Campylobacter concisus is an oral bacterium. Recent studies suggest that C. concisus may be involved in human gastric diseases. The mechanisms, however, by which C. concisus causes human gastric diseases have not been investigated. Here we examined the gastric epithelial pathogenicity of C. concisus using a cell culture model. Six C. concisus strains and the human gastric epithelial cell line AGS cells were used. IL-8 produced by AGS cells after incubation with C. concisus was measured using enzyme-linked immunosorbent assay (ELISA), and AGS cell apoptosis was determined by caspase 3/7 activities. The effects of C. concisus on actin arrangement in …

Metagenomic Characterisation Of The Gut Microbiome And Effect Of Complementary Feeding On Bifidobacterium Spp. In Australian Infants, Kimberley Parkin, Debra J. Palmer, Valerie Verhasselt, Nelly Amenyogbe, Matthew N. Cooper, Claus T. Christophersen, Susan L. Prescott, Desiree Silva, David Martino

Research outputs 2022 to 2026

Complementary feeding induces dramatic ecological shifts in the infant gut microbiota toward more diverse compositions and functional metabolic capacities, with potential implications for immune and metabolic health. The aim of this study was to examine whether the age at which solid foods are introduced differentially affects the microbiota in predominantly breastfed infants compared with predominantly formula-fed infants. We performed whole-genome shotgun metagenomic sequencing of infant stool samples from a cohort of six-month-old Australian infants enrolled in a nested study within the ORIGINS Project longitudinal birth cohort. Infants born preterm or those who had been administered antibiotics since birth were excluded. …

Pain Is Underestimated In Older Adults With Risk Of Falls, Mustafa Atee

Research outputs 2022 to 2026

Dear Editor, I have read with great interest the Xiao et al. study examining ret-rospectively the incidence of falls and related factors in outpatient and inpatient elderly sample (n= 451) aged 65 years and above. . . .

Pre- And Post-Harvest Elicitation With Methyl Jasmonate And Salicylic Acid Followed By Cold Storage Synergistically Improves Red Colour Development And Health-Promoting Compounds In Blood Oranges, Mekhala D. K. Vithana, Zora Singh, Mahmood Ul Hasan

Research outputs 2022 to 2026

Red blush is one of the key quality markers of blood orange fruit (Citrus sinensis L. Osbeck). Therefore, the influence of pre- (1, 2, and 3 mM) and postharvest (0.5, 1, and 1.5 mM) methyl jasmonate (MeJA) and salicylic acid (SA) (1, 2, and 3 mM) treatments on redness, colouring pigments, and health-promoting compounds in cold stored ‘Tarocco Ippolito’ blood oranges was investigated. Preharvest application of 3 mM MeJA significantly increased rind citrus colour index (CCI) by 43.3% and colorimetric coordinate a* (redness) by 3.1% and decreased h° (hue angle, 0 = red), L* (lightness), and b* (yellowness) by 13.7%, …

Professionalism In Artificial Intelligence: The Link Between Technology And Ethics, Anton Klarin, Hossein Ali Abadi, Rifat Sharmelly

Research outputs 2022 to 2026

Ethical conduct of artificial intelligence (AI) is undoubtedly becoming an ever more pressing issue considering the inevitable integration of these technologies into our lives. The literature so far discussed the responsibility domains of AI; this study asks the question of how to instil ethicality into AI technologies. Through a three-step review of the AI ethics literature, we find that (i) the literature is weak in identifying solutions in ensuring ethical conduct of AI, (ii) the role of professional conduct is underexplored, and (iii) based on the values extracted from studies about AI ethical breaches, we thus propose a conceptual framework …

Staff Perceptions On The Effectiveness Of Grip-S, A New Approach To Clinical Supervision Incorporating Safewards: An Interpretive Phenomenological Analysis, Jennifer Hamilton, Amanda Cole, Richard Bostwick, Irene Ngune

Research outputs 2022 to 2026

This study explored the impact of an innovative approach to clinical supervision for mental health nurses which integrates Safewards, named Group Reflective integrated Practice with Safewards–GRiP-S. Qualitative data was collected through 10 individual semi-structured interviews with nursing staff who had participated within the clinical supervision approach. Interviews provided insights into the nursing staff’s perception and experience of the clinical supervision approach. Through interpretive phenomenological analysis six themes emerged (i) illuminating embodied practice of Safewards, (ii) building confidence through empowering connections, (iii) creating a culture of positive change, (iv) identifying internal motivation for and external barriers to supervision engagement, (v) navigating …

Does Intrauterine Exposure To Diabetes Impact Mental And Motor Skills? A Meta-Analysis Of The Bayley Scales Of Infant Development, Diana Arabiat, Mahammad Al Jabery, Lisa Whitehead

Research outputs 2022 to 2026

Background: Attempts to conduct meta-analyses of the association between child development and diabetes have been limited by the wide range of tools and definitions of developmental outcomes used in the literature. We aim to meta-analyze a widely used measure of child development, the Bayley Scales of Infant Development, with respect to exposure to diabetes and developmental scores. Methods: PsycINFO, MEDLINE/PubMed, EMBASE, Emcare, and Google Scholar databases were searched. Two independent reviewers screened, extracted, and quality-appraised the studies using JBI SUMARI software. Forest plots were created with the standardized mean difference using the random-effects model, and heterogeneity was assessed using I2. …

The Report Of Access And Engagement With Digital Health Interventions Among Children And Young People: Systematic Review, Lisa Whitehead, Suzanne Robinson, Diana Arabiat, Mark Jenkins, Evalotte Morelius

Research outputs 2022 to 2026

Background: Digital health interventions are increasingly used to deliver health-related interventions for children and young people to change health behaviors and improve health outcomes. Digital health interventions have the potential to enhance access to and engagement with children and young people; however, they may also increase the divide between those who can access technology and are supported to engage and those who are not. This review included studies that reported on the access to or engagement with digital health interventions among children and young people. Objective: This review aims to identify and report on access and engagement in studies involving …

A Maturity Model For Micro-Credentialing And Shorter Forms Of Learning Practice In Australasian Universities, Ratna M. Selvaratnam, Steven Warburton, Dominique Parrish, Suzanne Crew

Research outputs 2022 to 2026

As education and training providers grapple with increasing demand for micro-credentials, guidance on how to improve providers’ capacity and capability to deliver a high standard of learning along with profitable outcomes is needed. This study sought to develop a maturity model that could assist higher education providers in distinguishing their stage of development for delivering micro-credentials and provide guidance on activities to advance micro-credential maturity. A survey of Australasian higher education providers validated the developed model and provided an indicator of the sector’s maturity and ability to meet the increasing demand for micro-credentials. The model’s domains of quality, resourcing, standards …

A Systematic Review Of Dementia Research Priorities, Manonita Ghosh, Pelden Chejor, Melanie Baker, Davina Porock

Research outputs 2022 to 2026

Introduction: Patient involvement is a critical component of dementia research priority-setting exercises to ensure that research benefits are relevant and acceptable to those who need the most. This systematic review synthesises research priorities and preferences identified by people living with dementia and their caregivers. Methods: Guided by Joanna Briggs Institute methodology, and Preferred Reporting Items for Systematic Reviews and Meta-Analyses framework, we conducted a systematic search in five electronic databases: CINAHL, Medline, PsycINFO, Web of Science and Scopus. The reference lists of the included studies were also manually searched. We combined quantitative and qualitative data for synthesis and descriptive thematic …

Assessing Alexithymia In Adolescents: Psychometric Properties Of The Perth Alexithymia Questionnaire In High School Students, Annette C. Trimble, Ken Robinson, David A. Preece

Research outputs 2022 to 2026

Conceptually, alexithymia is a key transdiagnostic risk factor for the development of numerous psychopathologies across the lifespan. However, to date, most alexithymia research has focused on adults, with adolescent work limited by a lack of validated age-appropriate assessment tools. Recently, the Perth Alexithymia Questionnaire (PAQ) was introduced to enhance the comprehensiveness of alexithymia assessments, but its psychometric properties have only been tested in adults. In this study, we address this by examining the psychometric properties of the PAQ in a sample of English-speaking high school students (N = 225, aged 11 to 18), and use the PAQ to further establish …

Fluid Biomarkers In Cerebral Amyloid Angiopathy, Seyed M. Savar, Bin Ma, Eugene Hone, Farzana Jahan, Shaun Markovic, Steve Pedrini, Soudabeh Shemehsavar, Vandhana Easwaran, Kevin Taddei, Samantha Gardener, Jasmeer P. Chhatwal, Ellis S. Van Etten, Matthias J. P. Van Osch, Daniel Clarke, Anastazija Gnjec, Mark A. Van Buchem, Marieke J. H. Wermer, Graeme J. Hankey, Steven M. Greenberg, Ralph N. Martins, Hamid R. Sohrabi

Research outputs 2022 to 2026

Cerebral amyloid angiopathy (CAA) is a type of cerebrovascular disorder characterised by the accumulation of amyloid within the leptomeninges and small/medium-sized cerebral blood vessels. Typically, cerebral haemorrhages are one of the first clinical manifestations of CAA, posing a considerable challenge to the timely diagnosis of CAA as the bleedings only occur during the later disease stages. Fluid biomarkers may change prior to imaging biomarkers, and therefore, they could be the future of CAA diagnosis. Additionally, they can be used as primary outcome markers in prospective clinical trials. Among fluid biomarkers, blood-based biomarkers offer a distinct advantage over cerebrospinal fluid biomarkers …

Exercise Professional Education, Qualifications, And Certifications: A Content Analysis Of Job Postings In The United States, Rachele Pojednic, Devin P. O’Neill, Molly G. Flanagan, Alexis Bartlett, Byron L. G. Carter, Mary A. Kennedy

Research outputs 2022 to 2026

Introduction: Growth in the field of clinical exercise science and the potential impacts on overall health and wellbeing have driven the need for qualified, clinically trained, exercise professionals. And yet, it is not well understood what specific credentials employers are seeking when hiring exercise professionals. Purpose: The purpose of the study was to examine the qualification requirements for professionals seeking employment in exercise science, exercise physiology, kinesiology or equivalent fields. Methods: Search platforms Indeed.com and USAJobs.gov were examined within a two week period in 2022. Search terms included “Exercise Physiology”, “Exercise Science”, “Exercise Professional”, “Exercise Prescription”, “Exercise Specialist”, and “Kinesiology”. …

Reduction And Recovery Of Self-Sustained Muscle Activity After Fatiguing Plantar Flexor Contractions, Anthony J. Blazevich, Ricardo N. O. Mesquita, Ronei S. Pinto, Timothy Pulverenti, Sébastien Ratel

Research outputs 2022 to 2026

Purpose: Persistent inward calcium and sodium currents (PICs) are crucial for initiation and maintenance of motoneuron firing, and thus muscular force. However, there is a lack of data describing the effects of fatiguing exercise on PIC activity in humans. We simultaneously applied tendon vibration and neuromuscular electrical stimulation (VibStim) before and after fatiguing exercise. VibStim induces self-sustained muscle activity that is proposed to result from PIC activation. Methods: Twelve men performed 5-s maximal isometric plantar flexor contractions (MVC) with 5-s rests until joint torque was reduced to 70%MVC. VibStim trials consisted of five 2-s trains of neuromuscular electrical stimulation (20 …

Overview Of Aboriginal And Torres Strait Islander Health Status 2023, Australian Indigenous Healthinfonet

Research outputs 2022 to 2026

The main purpose of the Overview of Aboriginal and Torres Strait Islander health status (Overview) is to provide a comprehensive summary of the most recent indicators of the health and current health status of Australia’s Aboriginal and Torres Strait Islander people. The Overview has been prepared by HealthInfoNet staff as part of our contribution to supporting those who work in the Aboriginal and Torres Strait Islander health sector. The Overview is a key indicator of the HealthInfoNet’s commitment to authentic and engaged knowledge development and exchange.

The initial sections of this Overview provide information about the context of Aboriginal and …

Summary Of Aboriginal And Torres Strait Islander Health Status - Selected Topics 2023, Australian Indigenous Healthinfonet

Research outputs 2022 to 2026

Aboriginal and Torres Strait Islander people have lived on their traditional lands across Australia, including the Torres Strait Islands, for upwards of 50,000 years and their continuity, history and cultural traditions are unrivalled in the world [1,2] . Before colonisation, Aboriginal and Torres Strait Islander people lived in family and community groups, and moved across the land following seasonal changes [1] . Aboriginal and Torres Strait Islander people developed complex societies, trading systems and agricultural activities that were celebrated and recorded in dance, song and stories [2] . The Aboriginal and Torres Strait Islander concept of health is not just …

Empowering Pro-Environmental Potential Among Hotel Employees: Insights From Self-Determination Theory, Ataul K. Patwary, S. M. Rasoolimanesh, Mohd H. Hanafiah, Roslizawati C. Aziz, Ahmad E. Mohamed, Muhammad U. Ashraf, Nor R. A. N. Azam

Research outputs 2022 to 2026

Purpose: This research examines the role of green, inclusive leadership, corporate social responsibility, and pro-environmental attitudes on proactive pro-environmental behaviour among hotel employees. It further examines the indirect effects of pro-environmental attitudes between green inclusive leadership, corporate social responsibility, and proactive pro-environmental behaviour, as well as the moderating role of psychological contract breach between pro-environmental attitudes and proactive pro-environmental behaviour.

Design/methodology/approach: The participants of this cross-sectional study were employees in the Malaysian hotel industry, and 374 usable questionnaires were used for data analysis. The data were analysed using Partial Least Squares – Structural Equation Modelling.

Findings: This study found that …

Opportunities And Challenges Posed By Disruptive And Converging Information Technologies For Australia's Future Defence Capabilities: A Horizon Scan, Pi-Shen Seet, Anton Klarin, Janice Jones, Mike Johnstone, Helen Cripps, Jalleh Sharafizad, Violetta Wilk, David Suter, Tony Marceddo

Research outputs 2022 to 2026

Introduction: The research project's objective was to conduct a comprehensive horizon scan of Network Centric Warfare (NCW) technologies-specifically, Cyber, IoT/IoBT, AI, and Autonomous Systems. Recognised as pivotal force multipliers, these technologies are critical to reshaping the mission, design, structure, and operations of the Australian Defence Force (ADF), aligning with the Department of Defence (Defence)’s offset strategies and ensuring technological advantage, especially in the Indo-Pacific's competitive landscape.

Research process: Employing a two-pronged research approach, the study first leveraged scientometric analysis, utilising informetric mapping software (VOSviewer) to evaluate emerging trends and their implications on defence capabilities. This approach facilitated a broader understanding …

Glycan Clock Of Ageing—Analytical Precision And Time-Dependent Inter- And I-Individual Variability, Borna Rapčan, Manshu Song, Azra Frkatović-Hodžić, Tea Pribić, Jakov Vuk, Anđelo Beletić, Maja Hanić, Julija Jurić, Petra Tominac, Josip Milas, Vedrana Ivić, Sven Viland, Sara Bonet, Branko Šego, Marija Heffer, Wei Wang, Michael P. Snyder, Gordan Lauc

Research outputs 2022 to 2026

Ageing is a complex biological process with variations among individuals, leading to the development of ageing clocks to estimate biological age. Glycans, particularly in immunoglobulin G (IgG), have emerged as potential biomarkers of ageing, with changes in glycosylation patterns correlating with chronological age. For precision analysis, three different plasma pools were analysed over 26 days in tetraplicates, 312 samples in total. In short-term variability analysis, two cohorts were analysed: AstraZeneca MFO cohort of 26 healthy individuals (median age 20) and a cohort of 70 premenopausal Chinese women (median age 22.5) cohort monitored over 3 months. Long-term variability analysis involved two …

Good Manufacturing Practice In Low- And Middle-Income Countries: Challenges And Solutions For Compliance, Pelden Chejor, Thinley Dorji, Ngawang Dema, Andrew Stafford

Research outputs 2022 to 2026

Approximately 2 billion people globally have limited access to essential medicines, particularly those living in low- and middle-income countries (LMICs). In addition, there is a higher prevalence of substandard and counterfeit medicines in LMICs, which may cause antimicrobial resistance and therapeutic failure. Good manufacturing practice (GMP) is key to ensuring access to high-quality, safe and effective medicines, including active pharmaceutical ingredients and excipients used for manufacturing finished dosage forms. Compliance with GMP standards saves resources for both manufacturers (e.g. avoiding expensive product recalls) and governments (e.g. minimising compliance inspections). Concerted collaborations among different countries to harmonise GMP standards and procedures …

Enablers And Barriers Of Online Mindfulness-Based Interventions For Informal Carers: A Mixed-Methods Systematic Review, Charunya Amilani Kumarihami Rambukwella Abeysinghe Mudiyanselage, Beverley Ewens, Aisling Smyth, Joanne Dickson, Seng Giap Marcus Ang

Research outputs 2022 to 2026

Objectives: Informal carers are an integral part of any health care system. However, provision of informal care is associated with caregiver burden and decreased wellbeing. Mindfulness programs can reduce caregiving burden and improve wellbeing among informal carers, but they face challenges when participating in face-to-face programs. Studies have explored the effects of online delivery of mindfulness programs for informal carers. However, the enablers and barriers for participation are not well understood. This review aimed to synthesise the evidence and provide a comprehensive understanding of the enablers and barriers to participation in online mindfulness programs among this population. Methods: A mixed-methods …

Analgesic Potential Of The Mimosa Pudica L. Leaf Decoction Using The Primary Dysmenorrhea Mouse Model, Paula Bianca D. De Guzman, Maria Dalisay G. Maligalig

Journal Article

Primary dysmenorrhea, a common menstrual pain, is often treated with nonsteroidal anti- inflammatory drugs (NSAIDs), which may cause side effects. In contrast, herbal medicine, such as Mimosa pudica L., has been used in the Philippines due to its accessibility and reportedly fewer side effects. This study investigated the analgesic potential of an aqueous M. pudica leaf decoction in a primary dysmenorrhea mouse model. Phytochemical analysis of the extract was also conducted and results revealed the presence of alkaloids, flavonoids, saponins, tannins, sterols, triterpenoids, and glycosides. Twenty sexually mature female ICR mice (Mus musculus) were orally pretreated with estradiol valerate for …

Ficus Diversity And Structure Along The Ulot River Riparian Zones In Samar Island Natural Park, Maria Celeste N. Banaticla-Hilario, Anne Frances V. Buhay, Lailani A. Masungsong, Diana Shane A. Balindo, Edelyn O. Echapare, Noba F. Hilvano, Inocencio E. Buot Jr.

Journal Article

Ficus species are keystone components of riparian ecosystems in Southeast Asia. Hence, studying their abundance and diversity in riparian areas can provide insights on the health and functions of the ecosystem. In this study, the diversity of Ficus along the riparian zone of Ulot River in Samar Island Natural Park (SINP) was evaluated by sampling across the upstream, midstream and downstream sections and using diversity indices and descriptive statistics to analyze the data. The Ulot riparian zone supports a phylogenetically diverse Ficus flora composed of 13 species representing five of the six subgenera. Three endemic species were observed namely, Ficus …

Assessing The Happiness Of University Of The Philippines Los Baños Faculty: Insights Into Academic Well-Being, Joyce Dl. Grajo, Nancy A. Tandang, Roselle V. Collado, Reanne Len C. Arlan, Maurice C. Borromeo, Edrun R. Gayosa, John Lorenzo A. Yambot

Journal Article

Faculty happiness is a key factor influencing productivity, engagement, and institutional commitment. This study examined the level of happiness among faculty members at the University of the Philippines Los Baños using an adopted instrument designed to yield a happiness index score. The self-report survey assessed dimensions such as psychological well-being, time balance, workplace environment, and career growth opportunities. Descriptive and correlation analyses were conducted to explore associations between faculty happiness and various personal and work- related factors. Specifically, Spearman's rank-order and point-biserial correlation coefficients were used to correlate happiness score with ordinal and dichotomous factors, respectively. Findings indicate that faculty …

Initial Clinical Experience With [177lu]Lu-Pnt2002 Radioligand Therapy In Metastatic Castration-Resistant Prostate Cancer: Dosimetry, Safety, And Efficacy From The Lead-In Cohort Of The Splash Trial, Aaron R Hansen, Jeff M Michalski, Et Al.

2020-Current year OA Pubs

INTRODUCTION: SPLASH (NCT04647526) is a multicenter phase III trial evaluating the efficacy and safety of [

METHODS: Enrolled participants had mCRPC that progressed on one prior androgen receptor pathway inhibitor (ARPI), were prostate-specific membrane antigen (PSMA) PET-positive as determined by a central reader, were chemotherapy-naïve for mCRPC, and had adequate bone marrow and end-organ reserve. Participants received up to 4 cycles of [

RESULTS: Of 34 individuals screened, 32 underwent PSMA-PET/CT; 27 met all eligibility criteria. Median (range) age was 72 (57-86) years; all participants were enrolled in North America; 40.7% initiated prior ARPI treatment without distant metastases (M0) and …

Development Of Tio2/Nh2-Mil-125 Nanocomposite For The Removal Of Ciprofloxacin Under Induced Solar Irradiation, Bilkis Mojisola Ajiwokewu

Theses

This research focuses on the development and application of Metal-Organic Frameworks (MOFs)-based nanocomposites for the photocatalytic removal of pharmaceutical contaminants, with a specific emphasis on ciprofloxacin (CIP). The photocatalytic degradation of CIP was investigated using as-synthesized photocatalysts of TiO₂ nanowires (TiO₂NWs), bare MOF of NH₂-MIL-125, TiO₂NW/NH₂-MIL-125 composite, and Lanthanum (La)-doped composite. Intriguingly, the TiO₂NW/NH₂-MIL-125 composite exhibited the highest efficiency, achieving a photodegradation rate of 0.0111 min-1, surpassing the independent performances of bare MOF of NH₂-MIL-125 and TiO₂NW. The observed efficiency was attributed to …

The Potential Effects Of Abiotic Stresses On Ziziphus And Acacia Species Grown Under Uae Climate Condition, Almaha Abdulla Alneyadi

Theses

This comprehensive thesis delves into a comparative analysis of two prominent desert plant species, namely Acacia and Ziziphus, shedding light on their distinct adaptive features in response to challenging environmental conditions. The exploration spans various facets, including the germination process, tap root development, and their reactions to water stress, ultimately revealing the superior hardiness and adaptability of Acacia over Ziziphus. In the realm of germination, Acacia stands out with its swift and efficient initiation, indicating a robust mechanism for establishing its presence in arid landscapes. The examination of tap root development further underscores the resilience of Acacia, as it demonstrates …

Study On The Chemical Composition And Antioxidant Activities Of Essential Oil Extracted From Horwoodia Dicksoniae Growing In The Uae, Salama Sari Al Mansoori

Theses

Plant-derived substances including essential oils, secondary metabolites and other chemical substances are gaining attention due to their broad spectrum use in different fields. Native medicinal plants can play a key role in the healthcare field in any country. Horwoodia dicksoniae is a native endangered plant in UAE. The current study is about the chemical composition and antioxidant properties of H. dicksoniae’s essential oil as well as the evaluation of growth of this native endangered plant under different environmental conditions. For this purpose, the first step included confirmation of the viability of seeds obtained from a seed bank following the …

New Treatment Modality For Metastatic Cancer By Targeting The Endothelin Type A Receptor (Etar), Elbara Fathelrahman Abdelmoula

Theses

Ambrisentan, an FDA-approved selective antagonist of the Endothelin Type A Receptor (ETAR) for pulmonary arterial hypertension, has shown potential in limiting cancer growth and metastasis. While effective treatment options for melanoma remain elusive, this study investigates the effects of Ambrisentan on invasive, metastatic B16F10 melanoma using a syngeneic mouse model, aiming to assess Ambrisentan’s impact on tumor growth, metastasis, and overall host survival in B16F10 melanoma, along with gaining mechanistic insights into ETAR antagonism. C57Bl/6 mice were divided into two groups, receiving either dH2O or Ambrisentan orally. Treatments commenced prior to tumor implantation and continued post-implantation. Luciferase-expressing B16F10 cells facilitated …