Digital Commons Network^™

The "New" Drug War, Jennifer D. Oliva, Taleed El-Sabawi

Articles by Maurer Faculty

American policymakers have long waged a costly, punitive, racist, and ineffective drug war that casts certain drug use as immoral and those who engage in it as deviant criminals. The War on Drugs has been defined by a myopic focus on controlling the supply of drugs that are labeled as dangerous and addictive. The decisions as to which drugs fall within these categories have neither been made by health agencies nor based on scientific evidence. Instead, law enforcement agencies have been at the helm of the drug war advocating for and enforcing prohibition.

The drug war has been a failure …

Through Smoke And Mirrors: Excluding Malingering Expert Testimony Under The Daubert Standard, Chunlin Leonhard, Christoph Leonhard

Georgia Law Review

Because of science’s claim to objectivity, scientific testimony is persuasive and often outcome-determinative. Our adversarial system incentivizes litigants to proffer scientific evidence to support their positions. The task falls on trial judges as gatekeepers to distinguish valid scientific evidence from junk science. Drawing this line is difficult because scientific evidence covers a broad spectrum. The United States Supreme Court has set forth the standard of admissibility of scientific evidence in Daubert and its progeny (the Daubert Standard). Trial judges are supposed to admit scientific evidence only if reliable and relevant under the Daubert Standard. But three decades after Daubert, …

Tomorrow Is A Mystery: Implementing Georgia’S Psychiatric Advance Directive Act, Suah Jang

Georgia Law Review

Mental health conditions exist in many adults today. One tool available to help them prepare for potential mental health crises is the psychiatric advance directive (PAD). Similar to medical advance directives, PADs allow individuals to create a plan in advance with specific directions regarding their mental health treatment to prepare for times of incompetence. Most states allow adults to create advance directives for general medical treatment, but creating advance directives for psychiatric treatment is a recent development.

This Note analyzes the implementation of Georgia’s Psychiatric Advance Directive Act (PAD Act), adopted in 2022. First, this Note provides an explanation and …

A Systems Biology Approach Unveils A Critical Role Of Dpp4 In Upper Gastrointestinal Cancer Patient Outcomes, Sudhir Kotnala, Anupam Dhasmana, Swati Dhasmana, Shafiul Haque, Murali Yallapu, Manish Tripathi, Meena Jaggi, Subhash Chauhan

School of Medicine Publications

Gastrointestinal (GI) cancers comprise of cancers that affect the digestive system and its accessory organs. The late detection and poor prognosis of GI cancer emphasizes the importance of identifying reliable and precise biomarkers for early diagnosis and prediction of prognosis. The membrane-bound glycoprotein dipeptidyl-peptidase 4 (DPP4), also known as CD26, is ubiquitously expressed and has a wide spectrum of biological roles. The role of DPP4/CD26 in tumor progression in different types of cancers remains elusive. However, the link between DPP4 and tumor-infiltrating cells, as well as its prognostic significance in malignancies, still require further investigation. This study was intended to …

False Discovery Rate And Localizing Power, Anderson M. Winkler, Paul A. Taylor, Thomas E. Nichols, Chris Rorden

School of Medicine Publications

False discovery rate (FDR) is commonly used for correction for multiple testing in neuroimaging studies. However, when using two-tailed tests, making directional inferences about the results can lead to vastly inflated error rate, even approaching 100% in some cases. This happens because FDR only provides weak control over the error rate, meaning that the proportion of error is guaranteed only globally over all tests, not within subsets, such as among those in only one or another direction. Here we consider and evaluate different strategies for FDR control with two-tailed tests, using both synthetic and real imaging data. Approaches that separate …

Riemannian Frameworks For The Harmonization Of Resting-State Functional Mri Scans, Nicolas Honnorat, Sudha Seshadri, Ron Killiany, John Blangero, David C. Glahn, Peter T. Fox, Mohamad Habes

School of Medicine Publications

Magnetic Resonance Imaging provides unprecedented images of the brain. Unfortunately, scanners and acquisition protocols can significantly impact MRI scans. The development of statistical methods able to reduce this variability without altering the relevant information in the scans, often coined harmonization methods, has been the topic of an increasing research effort supported by the recent growth of publicly available neuroimaging data sets and new possibilities for combining them to achieve greater statistical power. In this work, we focus on the challenges specifically raised by the harmonization of resting-state functional MRI scans. We propose to harmonize resting-state fMRI scans by reducing the …

Editorial: Genome-Wide Molecular Mechanisms Of Substance Use Disorders, Ilya O. Blokhin, David M. Martinez-Garza, Dhruti Patel, Antoine B. Douaihy, Ihsan M. Salloum

School of Medicine Publications

No abstract provided.

Novel Method Of Isolating Nuclei Of Human Oligodendrocyte Precursor Cells Reveals Substantial Developmental Changes In Gene Expression And H3k27ac Histone Modification, Alexey Kozlenkov, Ramu Vadukapuram, Ping Zhou, Peter Fam, Michael Wegner, Stella Dracheva

School of Medicine Publications

Oligodendrocyte precursor cells (OPCs) generate differentiated mature oligodendrocytes (MOs) during development. In adult brain, OPCs replenish MOs in adaptive plasticity, neurodegenerative disorders, and after trauma. The ability of OPCs to differentiate to MOs decreases with age and is compromised in disease. Here we explored the cell specific and age-dependent differences in gene expression and H3K27ac histone mark in these two cell types. H3K27ac is indicative of active promoters and enhancers. We developed a novel flow-cytometry-based approach to isolate OPC and MO nuclei from human postmortem brain and profiled gene expression and H3K27ac in adult and infant OPCs and MOs genome-wide. …

The Power Of The Story, Rogelio Paquini

Journal of Adventist Youth and Young Adult Ministries

When most people ignore the story of Scripture, there needs to be a different approach to reach them for Jesus regarding knowledge of the biblical narrative. The evangelistic system to reach this generation needs to change. The Next BIG Thing in youth ministry is returning to the power of storytelling. To reach this generation it is imperative to practice storytelling, especially the story of the Bible. Our identity as Seventh-day Adventists depends on the strength of our story in connection with prophetic and historical narratives. We get to tell a story of hope, not of disappointment; a story of cooperation …

Cognitive, Behavioral, And Circadian Rhythm Interventions For Insomnia Alter Emotional Brain Responses, Jeanne Leerssen, Moji Aghajani, Tom Bresser, Lara Rösler, Anderson M. Winkler, Jessica C. Foster-Dingley, Eus J.W. Van Someren

School of Medicine Publications

Background

Methods

A Grounded Theory Investigation Of Basic Psychological Needs Theory As A Framework For Effective Mental Health Referrals In Collegiate Sport, Luna Ugrenović

Graduate Theses, Dissertations, and Problem Reports (ETD)

Using a grounded theory approach, this study explored collegiate athletes’ mental health referral experiences and identified mechanisms explaining those experiences based upon perceptions of psychological need fulfillment and thwarting according to Basic Psychological Needs Theory (BPNT). Interviews were conducted with a purposive, maximum variation sample of 14 current and former collegiate athletes who were referred to mental health services by support personnel or other athletes. Analyses yielded three overarching theoretical categories/properties: pre-referral factors, proactive and reactive referral conversations, and referral outcomes. Referral is often understood as an isolated conversation in which athletes are provided mental health resources in response to …

From Trails To Triumph: Documenting Two Decades Of Impact With Adventure Wv, Sean Lowdermilk

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research paper and accompanying short film (https://youtu.be/gTnXbvkX0MA) examines the impact of experiential learning through the lens of Adventure WV, an outdoor orientation program at West Virginia University. Using Kolb's Experiential Learning Theory as a foundation for the research, this study explores how outdoor and expeditionary learning fosters personal and professional growth, builds a community, and deepens students' connection to the state and the institution. Through interviews with the program's founder, as well as current students and administration paired with archival footage and modern video, the research highlights Adventure WV's role in student retention, professional development, and student …

Efficient Classification Of Very High Resolution Images, Mohammad I. Nouyed

Graduate Theses, Dissertations, and Problem Reports (ETD)

In recent decades, deep learning approaches have shown significant improvement in various image understanding tasks. However, analysis of high-resolution images remains a major challenge. In this work, we address the challenge of very high-resolution histopathological image (VHRHI) classification using a new information-theoretic discriminative patch selection approach. We show results on a high-resolution image dataset, namely, gigapixel whole slide tissue images for cancer tumors. Then we address how to efficiently classify challenging histopathology images, such as gigapixel whole-slide images for cancer diagnostics with image-level annotation. These ``weak labels'' are applied throughout the image but describe tumor regions of variable sizes and …

Exploring Long-Term Patterns: Black Bass Tournament Fishery And Population Trends In West Virginia's Navigable Rivers, Alex J. Benecke

Graduate Theses, Dissertations, and Problem Reports (ETD)

Black bass Micropterus spp. are popular sport fish in West Virginia’s navigable rivers. In recent years, anglers have expressed concerns about a potential decline in fishery quality. To investigate these claims, we evaluated whether fishery quality has declined compared to earlier periods and whether population trends correspond to angler catch rates. Specifically, we aimed to (1) examine changes in species catch over time and during key periods, such as tournament and spawning seasons; (2) describe the distribution of black bass species across pools and habitat types; and (3) assess the outcomes of previous stocking efforts. To address these objectives, we …

Investigating Critical Mineral Recovery And Carbon Mineralization Potential In Coal Fly Ash, Syabilla Cardosh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Coal fly ash (CFA), a byproduct of coal combustion, represents an innovative opportunity to address the rising demand for critical minerals and the need to reduce CO2 emissions due to its significant concentrations of calcium and magnesium. By providing insights and preliminary data, this study aims to contribute to the foundational understanding necessary for future development.

A multidisciplinary approach was employed to assess CFA’s potential, including detailed chemical and mineralogical characterization using X-ray fluorescence (XRF), inductively coupled plasma mass spectrometry (ICP-MS), X-ray diffraction (XRD), and scanning electron microscopy (SEM). XRD analysis revealed crystalline phases in the CFA samples. At the …

Three Essays On Externalities Of Energy And Agricultural Production, Taiwo Foluso Akinyemi

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation consists of three essays exploring the externalities that arise from energy production and development in a developing country, Nigeria, and agricultural production in a developed nation, the United States (US). The research examines the benefits of energy development in terms of its impact on local wealth and the associated costs, including the health effects on communities living near energy production sites. Additionally, the dissertation analyzes the opportunity costs of policies aimed at preventing the relocation of nutrients, particularly nitrogen fertilizers, within the agricultural sector and their impact on the producer and consumer surplus.

The first essay examines the …

Effect Of Specific Data Variations On Automated Speaker Recognition, Ethan David Meighen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Speaker recognition is not a new biometric modality but there are still many obstacles in the way in order for it to become as used as fingerprint recognition, facial recognition, and iris recognition. Many real-world environmental conditions, hardware device variations, and human behavior present serious challenges to the use of opportunistic voice or speaker samples for identification purposes. Non-idealities, identified as nuisance factors, include environmental noise, input device quality, length of utterance, sample rate variation, and unscripted data are common nuisance factors that can impact speaker recognition match score performance. The impact of the nuisance factors listed above were evaluated …

A Multimodal Physical Fatigue Assessment Method Using A Biomarker And Accelerometer-Embedded Wearable Wristband, Md Hadisur Rahman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Physically demanding tasks pose significant challenges to worker health, safety, and productivity across various industrial sectors in the United States. The construction industry is particularly affected due to the labor-intensive nature of its tasks and harsh environmental conditions. The industry suffers from unsatisfactory occupational health and safety records, with physical fatigue being a major contributor. Physical fatigue not only affects individual well-being and workplace safety but also influences productivity and the United States’ economy. Given the high incidence of injuries and accidents in the construction industry, assessing physical fatigue has become critical for improving worker safety and productivity. To address …

Development Of An Order Set To Improve Consistency Of Blood Glucose Monitoring For Hospitalized Patients On Enteral Feeding, Kristen Calebaugh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Development of an Order set to Improve Consistency of Blood Glucose Monitoring for Adult Hospitalized Patients on Enteral Feeding

Kristen Calebaugh, BSN, RN

Background

Hospitalized patients often require artificial nutrition through either enteral feeding, placing the patient at risk for glucose alterations related to physiological responses of nutritional metabolism. Historically, there has been no standard of care or consistency aligning tube feedings times with point of care blood glucose testing. Without a standardized order set to guide blood glucose monitoring orders, patients on artificial nutrition may experience undetected hypo or hyperglycemia or inadequate glycemic control, which can cause adverse …

Polylactic Acid (Pla) Containing Talc Microparticles And Amorphous Polyhydroxyalkanoates (Aphas) For Improved Barrier And Mechanical Properties In Food Packaging, Mohammed Alfaifi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Polylactic acid (PLA) is a biobased and compostable polymer that is increasingly being used as an alternative to petroleum-based, non-biodegradable polymers for single-use food packaging due to its environmental benefits. It is also commercially available in large quantities, and it can be processed like polyethylene. However, it has a higher water-vapor permeability (WVP) as compared to polyolefins and polyethylene terephthalate that are the incumbent materials. This results in a competitive disadvantage in employing PLA for packaging baked goods since the shelf life of the food is likely to be reduced. In the past, barrier properties of PLA were improved by …

A Multidisciplinary Approach To Identify Postoperative Delirium In Geriatric Patients Using A Brain Health Screening Tool, Ashlyn Mccartney

Graduate Theses, Dissertations, and Problem Reports (ETD)

Postoperative delirium (POD) is a common occurrence, effecting nearly 61% of the surgical population recovering from anesthesia. POD increases risk of morbidity and mortality leading to prolonged hospital length of stay by 0.8 to 7.3 days and increased costs by $1,551 to $23,698 (Masharaf et al., 2022; Sethi, 2021). An academic medical center in northern West Virginia (WV) lacks a structured practice/protocol to identify high risk patients and assess POD. An evidence-based solution was developed based on the PICO question: Does a multidisciplinary approach to perianesthetic care utilizing a brain health screening tool, compared to lack of a screening tool, …

Symptoms Of Anxiety, Trauma, Depression, And Obsessive-Compulsive Disorders In A Subsequent Pregnancy Following A Previous Pregnancy Loss, Juliana Lynn Restivo Haney

Graduate Theses, Dissertations, and Problem Reports (ETD)

Pregnancy loss is a common and intense personal event that has been found to be a risk factor for increased symptoms of mood, trauma, obsessive-compulsive and anxiety disorders in subsequent pregnancies. Using a self-report online survey, the current study hypothesizes that levels of anxiety, trauma, and obsessive-compulsive symptoms will be higher in pregnant individuals who had a pregnancy loss in their most recent previous pregnancy (n= 61) when compared to pregnant individuals whose most recent previous pregnancy resulted in a live birth (n= 62). Participants responded to an online questionnaire asking about reproductive and mental health history, symptoms of perinatal …

An Examination Of The Stability Of The Remembering Self When Measuring Social Connection Derived From A Shared Leisure Experience, Camilla Hodge, Karen K. Melton, Mat D. Duerden, Mark A. Widmer, Aubrey Rushton, Alexis Kelley

Faculty Publications

Social connection has been identified as a public health priority, and is often positioned, in various forms, as an outcome of leisure experiences. In cases of assessing the hedonic quality of experiences, research has identified a relative permanence and stability in the remembering self; however, whether the same is true when measuring social connection is unknown. Therefore, this study aimed to determine whether recall of social connection after a structured, shared leisure experience changed over time. We compared assessments of social connection among a sample of 68 adults immediately following four structured, shared leisure experiences and again four weeks later. …

Artificial Intelligence And Mediation Ethics, Zachary R. Calo

Scholarly Works

No abstract provided.

Chatbots Mitigate Help-Seeking Avoidance, James Gaskin, Eva Blondeel, Ryan Schuetzler, Rachel Serre, Jacob Steffen, David A. Wood

Faculty Publications

This research explores the transformative role of large language model (LLM) chatbots in fostering help-seeking behaviors among introverted and underrepresented students in educational settings. Despite the importance of help-seeking for academic success, certain groups exhibit avoidance behaviors due to self-presentation concerns and stereotype threats. By integrating LLM chatbots as non-judgmental, anonymous teaching assistants in an introductory information systems course, the study demonstrates how technology can mitigate these behaviors and promote inclusivity. The chatbots provided real-time, unbiased support, significantly enhancing the students' willingness to engage in help-seeking behaviors without fear of judgment. This practical application of chatbots not only supports academic …

Tax Sentiment And Compliance: Evidence From Social Media, Andrew Belnap, Jacob Thornock, Kevin Standridge, Braden Williams

Faculty Publications

Motivations for voluntary tax compliance that fall outside of a standard, rational model can be intrinsic or extrinsic. We use social media rhetoric about taxes to create a measure of tax sentiment that reflects taxpayers’ extrinsic, behavioral motivations for voluntary compliance, and then examine the association between public tax sentiment and tax compliance. Our machinelearning based approach for measuring sentiment uses millions of tax-related tweets, which vary by time and geography. We find that tax sentiment is negatively associated with tax compliance. Our main findings and cross-sectional tests are consistent with the notion that paying one’s taxes is a way …

“Words Of Plainness” Jacob’S Apology, His Addendum, And The Competing Forms Of Nephite Worship, Dan Belnap, Rob Hernandez

Faculty Publications

Jacob’s powerful essay in Jacob chapters 4–6 ends with this statement: “I bid you farewell, until I shall meet you before the pleasing bar of God, which bar striketh the wicked with awful dread and fear. Amen” (Jacob  6:13). The essay represents Jacob’s teachings as a Nephite priest concerning the centrality of Christ in the religious and doctrinal framework of his Nephite congregation. It fits within the greater structure of the book of Jacob, which appears to be governed by Nephi1’s instructions concerning what should be included on the small plates. Recorded by Jacob in Jacob 1, the instruction suggests …

The Intellectual Structure Of Audit Committee Research: A Bibliometric Analysis (1969 – 2020), Joel Behrend, Marc Eulerich, David A. Wood

Faculty Publications

The audit committee is a widely recognized mechanism of effective corporate governance. We advance prior literature reviews by using bibliometric analysis techniques that comprehensively process large bodies of bibliometric information. We base inferences on citation patterns of 1,173 articles to identify concepts that “shine through” within the scientific understanding of audit committees. Using content analysis, we then analyze these concepts and explore existing interrelationships. We document a declining influence of audit committee research, as well as a widening gap between the quantitative and qualitative research camps. While the former is mostly derivative in nature, the latter produces innovative insights on …

Aerosol Jet Printing Of Surface Acoustic Wave Microfluidic Devices, Joseph Rich, Brian Cole, Teng Li, Brandon Lu, Hanyu Fu, Brittany N. Smith, Jianping Xia, Shujie Yang, Ruoyu Zhong, James L. Doherty, Kanji Kaneko, Hiroaki Suzuki, Zhenhua Tian, Aaron D. Franklin, Tony Jun Huang

Faculty Publications

The addition of surface acoustic wave (SAW) technologies to microfluidics has greatly advanced lab-on-a-chip applications due to their unique and powerful attributes, including high-precision manipulation, versatility, integrability, biocompatibility, contactless nature, and rapid actuation. However, the development of SAW microfluidic devices is limited by complex and time-consuming micro/nanofabrication techniques and access to cleanroom facilities for multistep photolithography and vacuum-based processing. To simplify the fabrication of SAW microfluidic devices with customizable dimensions and functions, we utilized the additive manufacturing technique of aerosol jet printing. We successfully fabricated customized SAW microfluidic devices of varying materials, including silver nanowires, graphene, and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate …

Media Conglomeration, Local News, And Capital Market Consequences, Travis Dyer, Mark Lang, Jun Oh

Faculty Publications

We examine the effect of news media consolidation on local business coverage and its consequences for firms, investors, and capital markets. Using television transcripts, we find a substantial drop in coverage of local firms following the consolidation of local television stations associated with Sinclair acquisitions. Local information search, institutional portfolio local bias, and overall retail trading decrease for firms in treated geographic areas. Results are most pronounced for small firms, for stations with higher ex ante viewership, and for stations with greater reductions in local coverage. Our results provide insight into the consequences of media consolidation for local business coverage, …