Digital Commons Network^™

Tumor Integrin Targeted Theranostic Iron Oxide Nanoparticles For Delivery Of Caffeic Acid Phenethyl Ester: Preparation, Characterization, And Anti-Myeloma Activities., Barkley Smith, Yuancheng Li, Travis Fields, Michael Tucker, Anna Staskiewicz, Erica Wong, Handong Ma, Hui Mao, Xinyu Wang

PCOM Scholarly Works

Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells preferentially in the bone marrow. Currently, emerging chemotherapy drugs with improved biosafety profiles, such as immunomodulatory agents and protease inhibitors, have been used in clinics to treat MM in both initial therapy or maintenance therapy post autologous hematopoietic stem cell transplantation (ASCT). We previously discovered that caffeic acid phenethyl ester (CAPE), a water-insoluble natural compound, inhibited the growth of MM cells by inducing oxidative stress. As part of our continuous effort to pursue a less toxic yet more effective therapeutic approach for MM, the objective of this study …

Imagine If All Schools Had This! Fostering Inclusive Family Engagement Through Human-Centered Design Thinking, Tamara R. York

Education Dissertations

This ethnographic study explores the crucial role of family engagement in educational systems and the impact a human-centered design team has on students' success at an elementary school. The research addresses the historical impact of racism and colonization on student outcomes alongside the ongoing challenge of narrowing the opportunity gap. Current interventions and support services, though significant, often adopt a remedial stance and are grounded in deficit thinking rather than embracing an asset-based approach. The research proposes a shift from traditional school-initiated family engagement to a human-centered design (HCD) approach to address these challenges. The purpose of the study is …

Frequently Asked Questions: Barry Conservation Camp, Andy Schafermeyer

UNH Cooperative Extension

No abstract provided.

Regulatory Approaches To Consumer Protection In The Financial Sector And Beyond: Towards A Smart Disclosure Regime?, Nydia Remolina, Yvonne Ai-Chi Loh, David Hardoon

International Journal on Consumer Law and Practice

Consumer and data protection policies often focus on consent and information disclosure. The purpose of these regulatory strategies is the protection of consumers by reducing some contracting failures, such as asymmetries of information and a lower bargaining power, especially in transactions involving complex issues such as financial products and sensitive personal data. In the past, regulators have responded to privacy and consumer protection by adopting what this article refers to as an “imperfectly informed regime”, in which consumers do not receive full information about the risks associated with their decisions, even if they are still protected through a variety of …

Exploring The True Shade Of Green: A Critical Examination Of The Central Consumer Protection Authority’S Guidelines On Corporate Greenwashing, Sanya Darakhshan Kishwar, Vasatika Saraswat, Roshni Agarwal

International Journal on Consumer Law and Practice

The Central Consumer Protection Authority in India has recently released draft guidelines to address the issue of greenwashing by corporations. This paper closely examines these guidelines and how they might impact the deceptive environmental practices of some companies. The study contributes to the ongoing discussion about corporate responsibility in India, highlighting the role of regulations in tackling greenwashing and promoting consumer trust. The authors critically comment on the shortcomings of the guidelines, while suggesting recommendations for resolving the same.

Impact Of Social Media Influencers On Consumer Choice: A Case Study Of Reviews By Youtubers, Faisal Fasih

International Journal on Consumer Law and Practice

Consumer participation is vital for businesses, especially in online markets, because potential customers cannot physically check the product. One of the standard options is to watch the review on YouTube, a source of a host of information, including consumer-related products. However, it also provides a fertile ground for disseminating misinformation, including fake reviews of consumer goods, because the contents of the information are unverified. Fake reviews can create information asymmetry, lead to the dismissal of genuine reviews, and ultimately reduce market competition. Therefore, one would have expected that the popularity of YouTube would decrease as a source of information access. …

2024-2025 Graduate Catalog, Morehead State University. Registrar's Office.

Morehead State Catalog Archive

2024-2025 graduate catalog for Morehead State University.

2024-2025 Undergraduate Catalog, Morehead State University. Registrar's Office.

Morehead State Catalog Archive

2024-2025 undergraduate catalog for Morehead State University.

Myopia Progression Following 0.01% Atropine Cessation In Australian Children: Findings From The Western Australia – Atropine For The Treatment Of Myopia (Wa-Atom) Study, Samantha Sze Yee Lee, Vinay Kumar Nilagiri, Gareth Lingham, Magdalena Blaszkowska, Paul G. Sanfilippo, Maria Franchina, Antony Clark, David A. Mackey

Articles

Background: A rebound in myopia progression following cessation of atropine eyedrops has been reported, yet there is limited data on the effects of stopping 0.01% atropine compared to placebo control. This study tested the hypothesis that there is minimal rebound myopia progression after cessation of 0.01% atropine eyedrops, compared to a placebo. Methods: Children with myopia (n = 153) were randomised to receive 0.01% atropine eyedrops or a placebo (2:1 ratio) daily at bedtime during the 2-year treatment phase of the study. In the third year (wash-out phase), all participants ceased eyedrop instillation. Participants underwent an eye examination every 6 …

Comparison For The Effects Of Different Components Of Temperature Variability On Mortality: A Multi-Country Time-Series Study, Multi-Country Multi-City (Mcc) Collaborative Network, Patrick Goodman

Articles

Background: Temperature variability (TV) is associated with increased mortality risk. However, it is still unknown whether intra-day or inter-day TV has different effects. Objectives: We aimed to assess the association of intra-day TV and inter-day TV with all-cause, cardiovascular, and respiratory mortality. Methods: We collected data on total, cardiovascular, and respiratory mortality and meteorology from 758 locations in 47 countries or regions from 1972 to 2020. We defined inter-day TV as the standard deviation (SD) of daily mean temperatures across the lag interval, and intra-day TV as the average SD of minimum and maximum temperatures on each day. In the …

All-Cause, Cardiovascular, And Respiratory Mortality And Wildfire-Related Ozone: A Multicountry Two-Stage Time Series Analysis, Multi-Country Multi-City (Mcc) Collaborative Network, Patrick Goodman

Articles

Background: Wildfire activity is an important source of tropospheric ozone (O3) pollution. However, no study to date has systematically examined the associations of wildfire-related O3 exposure with mortality globally. Methods: We did a multicountry two-stage time series analysis. From the Multi-City Multi-Country (MCC) Collaborative Research Network, data on daily all-cause, cardiovascular, and respiratory deaths were obtained from 749 locations in 43 countries or areas, representing overlapping periods from Jan 1, 2000, to Dec 31, 2016. We estimated the daily concentration of wildfire-related O3 in study locations using a chemical transport model, and then calibrated and downscaled O3 estimates to a …

Laser-Irradiating Infrared Attenuated Total Reflection Spectroscopy Of Articular Cartilage: Potential And Challenges For Diagnosing Osteoarthritis, P. Krebs, M. Nägele, P. Fomina, V. Virtanen, E. Nippolainen, R. Shaikh, I. O. Afara, J. Töyräs, I. Usenov, T. Sakharova, V. Artyushenko, V. Tafintseva, J. H. Solheim, B. Zimmermann, A. Kohler, O. König, S. Saarakkala, B. Mizaikoff

Articles

Objective: A prototype infrared attenuated total reflection (IR-ATR) laser spectroscopic system designed for in vivo classification of human cartilage tissue according to its histological health status during arthroscopic surgery is presented. Prior to real-world in vivo applications, this so-called osteoarthritis (OA) scanner has been tested at in vitro conditions revealing the challenges associated with complex sample matrices and the accordingly obtained sparse spectral datasets. Methods: In vitro studies on human knee cartilage samples at different contact pressures (i.e., 0.2–0.5 ​MPa) allowed recording cartilage degeneration characteristic IR signatures comparable to in vivo conditions with high temporal resolution. Afterwards, the cartilage samples …

The Multi-Country Multi-City Collaborative Research Network An International Research Consortium Investigating Environment, Climate, And Health, Multi-Country Multi-City (Mcc) Collaborative Network, Patrick Goodman

Articles

Research on the health risks of environmental factors and climate change requires epidemiological evidence on associated health risks at a global scale. Multi-center studies offer an excellent framework for this purpose, but they present various methodological and logistical problems. This contribution illustrates the experience of the Multi-Country Multi-City Collaborative Research Network, an international collaboration working on a global research program on the associations between environmental stressors, climate, and health in a multi-center setting. The article illustrates the collaborative scheme based on mutual contribution and data and method sharing, describes the collection of a huge multi-location database, summarizes published research findings …

Regional Variation In The Role Of Humidity On City-Level Heat-Related Mortality, Multi-Country Multi-City (Mcc) Collaborative Network, Patrick Goodman

Articles

The rising humid heat is regarded as a severe threat to human survivability, but the proper integration of humid heat into heat-health alerts is still being explored. Using state-of-the-art epidemiological and climatological datasets, we examined the association between multiple heat stress indicators (HSIs) and daily human mortality in 739 cities worldwide. Notable differences were observed in the long-term trends and timing of heat events detected by HSIs. Air temperature (Tair) predicts heat-related mortality well in cities with a robust negative Tair-relative humidity correlation (CT-RH). However, in cities with near-zero or weak positive CT-RH, HSIs considering humidity provide enhanced predictive power …

Impact Of Population Aging On Future Temperature-Related Mortality At Different Global Warming Levels, Multi-Country Multi-City (Mcc) Collaborative Network, Patrick Goodman

Articles

Older adults are generally amongst the most vulnerable to heat and cold. While temperature-related health impacts are projected to increase with global warming, the influence of population aging on these trends remains unclear. Here we show that at 1.5 °C, 2 °C, and 3 °C of global warming, heat-related mortality in 800 locations across 50 countries/areas will increase by 0.5%, 1.0%, and 2.5%, respectively; among which 1 in 5 to 1 in 4 heat-related deaths can be attributed to population aging. Despite a projected decrease in cold-related mortality due to progressive warming alone, population aging will mostly counteract this trend, …

Global, Regional, And National Burden Of Mortality Associated With Cold Spells During 2000–19: A Three-Stage Modelling Study, Multi-Country Multi-City (Mcc) Collaborative Network, Patrick Goodman

Articles

Background: Exposure to cold spells is associated with mortality. However, little is known about the global mortality burden of cold spells. Methods: A three-stage meta-analytical method was used to estimate the global mortality burden associated with cold spells by means of a time series dataset of 1960 locations across 59 countries (or regions). First, we fitted the location-specific, cold spell-related mortality associations using a quasi-Poisson regression with a distributed lag non-linear model with a lag period of up to 21 days. Second, we built a multivariate meta-regression model between location-specific associations and seven predictors. Finally, we predicted the global grid-specific …

If You Build It, They Will Come: The Rise Of Public-Private Partnerships And Its Implications On The United States Infrastructure System, Matthew Hahn

Fordham Urban Law Journal Online

No abstract provided.

Access To Civil Justice For Parents In The U.S. Child Welfare System, Caitlin Rubin

Fordham Urban Law Journal Online

No abstract provided.

Rock Hill Chapter Of The American Red Cross - Accession 466, American Red Cross, Rock Hill Chapter

Manuscript Collection

The Rock Hill Chapter of the American Red Cross Records consist of correspondence, memoranda, minutes, reports, bylaws, financial records, lists of workers, newsletters, scrapbooks, newspaper clippings, and photographs relating to the work of the Rock Hill Chapter, Fort Mill Branch, and Winthrop group. Subjects include disaster relief, volunteers, courses of instruction, aid and services to soldiers and veterans of World War II and Vietnam, Junior Red Cross, blood donation, Suzanne Johnson (Daughter of David B. Johnson), and the Sunshine Club for the visually impaired. Also included are uniforms and caps. Much of the collection consists of American National Red Cross …

Presbyterian Church Of The United States Coalition On Health Records - Accession 465, Coalition On Health, Presbyterian Church Of The United States

Manuscript Collection

The Presbyterian Church of the United States Coalition on Health was “an advisory group of Presbyterians whose primary function was to: (1) to advise the General Assembly Mission Board in the areas of health care; (2) to define the nature of the health ministry of the P.C.U.S; and (3) to assist local churches in responding to health concerns.” The collection includes correspondence, speeches, minutes of the Coalition on Health from the years 1977-1979 and the 1974, Conference at Montreat, reference materials and papers relating to national health care, insurance, separation of church and state, international health, and interest groups, a …

Constance Myers Papers - Accession 725, Constance Ashton Smith Myers

Manuscript Collection

This collection consists of letters, lesson plans, examination, photographs, student papers written, course syllabi, newspaper articles, excerpts of written material for class handouts. Constance Ashton Myers was a historian, author, and professor born in 1927 affectionately known to her family and friends as Connie. During the 1970s, Myers traveled around the United States and interviewed Suffragettes and other women and recorded their interviews. She participated actively in the women’s liberation movement throughout her years giving speeches, writing books, and interviewing women. Dr. Myers attended and taught at Sacramento State College, University of South Carolina at Aiken, and Augusta College as …

Alice Mccarter Pursley Papers - Accession 701, Alice Mccarter Pursley

Manuscript Collection

The Alice McCarter Pursley Papers consists of material collected by Alice McCarter Pursley (1902-1987) during her college career at Winthrop College and during her extensive teaching career. This includes college transcripts and grade reports, correspondence, teacher certification documentation, journals, programs, teacher’s attendance registers, newspaper and magazine clippings, student information, and other memorabilia. This collection consists of records including attendance records from her time at Lugoff Elementary School in Kershaw County, S.C., Sutton Springs School, Cotton Belt School, and York Elementary School in York County, SC.

Rev. Cecil A. Ivory Papers - Accession 1730, Cecil Augustus Ivory

Manuscript Collection

The Rev. Cecil Augustus Ivory Papers document the personal, academic, religious, and civil rights activities of Rev. Cecil Augustus Ivory (1921–1961), a prominent Rock Hill, South Carolina minister and civil rights leader. The materials span from the late nineteenth century to the late twentieth century, with the bulk dating from the 1940s through the early 1960s.

The collection includes personal and professional correspondence, academic papers, newspaper clippings, church records, organizational records, scrapbook materials, artifacts, and a personal book collection. Personal correspondence includes letters, postcards, and a telegram exchanged between Ivory and his family, including correspondence with his future wife, Emily …

Williams Family Winthrop Collection - Accession 1784, Williams Family, Winthrop College, Isadora Williams, Una Williams Johnson, Laura Mae Williams Griffith, Betsy Griffith Rabon

Manuscript Collection

The Williams Family Winthrop Collection consists of Tatlers, photographs, letters, notes, patches, newspaper clippings, and scrapbooks belonging to three generations of the Williams family. Records all pertain to Winthrop. This material offers a great snapshot into the lives of a Winthrop student through several generations of the Williams and Griffith family. The members of the Williams family include Winthrop Class of 1908, Isadora Williams (1884-1976), Winthrop Class of 1926, Una Williams Johnson (1903-1999), Winthrop Class of 1942 and niece of Isadora and Una, Laura Williams Griffith (1922-2002), and Winthrop Class of 1975 and daughter of Laura, Betsy Griffith Rabon.

Short-Term Effects Of Cyclopentolate And Tropicamide Eye Drops On Macular Choroidal Thickness In Myopic Children, Emmanuel Kobia-Acquah, Daniel Ian Flitcroft, Gareth Lingham, Eoin Kerin, James Loughman

Articles

Background: To investigate the short-term effects of cyclopentolate and tropicamide eyedrops on choroidal thickness (ChT) in myopic children using placebo or low-dose atropine eyedrops. Methods: The analysis included 242 myopic individuals (7–19 years) enrolled in two randomised placebo-controlled clinical trials of low-dose atropine eyedrops. Cycloplegia was induced using either one drop of 1% cyclopentolate (n = 161), two drops of 1% cyclopentolate (n = 32) or two drops of 1% tropicamide (n = 49). ChT measurements were taken using swept-source optical coherence tomography before and 30 min after administering the cycloplegic eye drops. A subset of 51 participants underwent test–retest …

A Comparative Study On Feature Extraction Techniques For The Discrimination Of Frontotemporal Dementia And Alzheimer's Disease With Electroencephalography In Resting-State Adults, Utkarsh Lal, Arjun Vinayak Chikkankod, Luca Longo

Articles

Early-stage Alzheimer's disease (AD) and frontotemporal dementia (FTD) share similar symptoms, complicating their diagnosis and the development of specific treatment strategies. Our study evaluated multiple feature extraction techniques for identifying AD and FTD biomarkers from electroencephalographic (EEG) signals. We developed an optimised machine learning architecture that integrates sliding windowing, feature extraction, and supervised learning to distinguish between AD and FTD patients, as well as from healthy controls (HCs). Our model, with a 90% overlap for sliding windowing, SVD entropy for feature extraction, and K-Nearest Neighbors (KNN) for supervised learning, achieved a mean F1-score and accuracy of 93% and 91%, 92.5% …

High Amniotic Fluid Fractalkine And Mip-1Β Levels Are Associated With Intrauterine Growth Restriction: A Prospective Cohort Study, Şehmus Pala, Remzi Atilgan, Nevin İlhan

Turkish Journal of Medical Sciences

Proinflammatory chemokines have been shown to play crucial roles in implantation, spiral artery invasion, and thefetomaternal immunological response. In this context, we investigated the levels of fractalkine (CX3CL1) and chemokine CC motifligand 4 (CCL4 or MIP-1β) in maternal serum and amniotic fluids in pregnant women with intrauterine growth restriction (IUGR).Materials and methods: This prospective cohort study was carried out at Fırat University Obstetrics Clinic between January 1, 2022 andJuly 1, 2022. Group (G) 1: The control group consisted of 40 pregnant women who underwent elective cesarean section (CS) at 38–40weeks of gestation. G2: A total of 40 pregnant women with …

Evaluation Of Single-Layer Versus Double-Layer Suturing Of Low Transverse Uterine Incisions In Cesarean Section And Follow-Up Of Scars By Ultrasound: A Prospective Randomized Controlled Study, Erhan Demi̇rdağ, Hazal Kutlucan, Anil Tutal, Bi̇lge Çalişkan Keski̇nsoy, Gülşah Karakuyu, Recep Karabacak

Turkish Journal of Medical Sciences

Background/aim: Cesarean section(CS) is a widely performed operation worldwide. Data about uterine closure is lacking. We aimed to evaluate scar niches and compare the single and double-layer uterine closure after six months following CS.Materials-Methods: A prospective, randomized trial assessed 56 women undergoing single or double-layer uterine closure. None of the patients had previous uterine surgery. The CSs were elective cases. Transvaginal ultrasound was performed six months after CS to assess uterine scar by measuring the width, depth, and length of scar niche and residual myometrial thickness. An experienced sonographer was blinded to the uterine closure technique and the ultrasounds were …

Comparison Of Classical Methods For Bone Age Determination With Capitohamate Planimetry On Wrist X-Rays, Hasan Yildiz, Nadi̇re Ünver Doğan, Mehmet Öztürk, Zeli̇ha Fazlioğullari, Muslu Körez, Ahmet Karabulut

Turkish Journal of Medical Sciences

Background/aim: This study aims to compare the Greulich–Pyle (GP) and Tanner–Whitehouse 2 (TW2) methods, both used in left wrist radiography for bone age determination in the pediatric age group, with the Capitohamatum method (CH) due to the importance of determining bone age in the pediatric period.Materials and methods: Direct radiographs of 210 female and 291 male individuals between the ages of 0–15 without any pathology in the left wrist bones were obtained; 501 os capitatum and os hamatum on anterior-to-posterior direct graphic images were measured using the GP, TW2, and CH planimetry methods. The estimated age of each measurement was …

Incorporating Novel Bio-Mineral Materials Of Silicone-Arrowroot Modified Starch For Compressed Powder, Pirada Sudprasert, Ananthaya Sansawat, Piangkhwan Kruapoo

Journal of Metals, Materials and Minerals

Incorporating novel bio-mineral materials of silicone-arrowroot modified starch (SA) is an environmentally friendly technique to create compressed powder, thereby integrating biodiversity with sustainability and responding to the Bio-Circular-Green (BCG) economy. The SA had improved flowability and water resistance compared with non-modified arrowroot flour (A0), concurring with the Fourier Transform Infrared (FTIR), scanning electron microscope (SEM) analyses that indicated more hydrophobic properties. To investigate the formulated dust and compressed powder, three types of binders including magnesium stearate (Ms), isopropyl myristate (Im), and mineral oil (Mo) were examined. Powder samples of all binders at each concentration gave high water resistance with floating …