Digital Commons Network^™

Inventory Management System For Medical Stores In A Primary Health Care Centre In Jada, Adamawa State, Nigeria, Daniel Dzarma Ezra, G Delga, N Nyor, K. T Dagba, M. A Samuel

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Efficient inventory management is crucial for the success of any organization or establishment. Hence, the objective of this paper was to focus on the inventory management system by developing an optimal inventory policy for Medical Stores in a Primary Health Care Centre in Jada, Adamawa State, Nigeria using a multiitem inventory model with the assistance of Excel spreadsheets. Results obtain revealed that the Economic Order Quantity (EOQ) for the Primary Health Care centre under investigation is optimal at 0.0086. This EOQ aligns with the storage capacity of 10,287 square meters, which closely meets the original storage capacity requirement of 10,288 …

Enhanced Neonatal Screening For Sickle Cell Disease: Human-Guided Deep Learning With Cnn On Isoelectric Focusing Images, Kpangni Alex Jérémie Koua, Cheikh Talibouya Diop, Lamine Diop, Mamadou Diop

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Accurate detection of abnormal hemoglobin variations is paramount for early diagnosis of sickle cell disease (SCD) in newborns. Traditional methods using isoelectric focusing (IEF) with agarose gels are technician-dependent and face limitations like inconsistent image quality and interpretation challenges. This study proposes a groundbreaking solution using deep learning (DL) and artificial intelligence (AI) while ensuring human guidance throughout the process. The system analyzes IEF gel images with convolutional neural networks (CNNs), achieving over 98% accuracy in identifying various SCD profiles, far surpassing the limitations of traditional methods. Furthermore, the system addresses ambiguities by incorporating an “Unconfirmed” category for unclear cases …

An Android-Based Internet Of Medical Things Adaptive User Authentication And Authorization Model For The Elderly, Prudence Munyaradzi Mavhemwa, Marco Zennaro, Philibert Nsengiyumva, Frederic Nzanywayingoma

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Globally, 77% of the elderly aged 65 and above suffer from multiple chronic ailments, according to recent research. However, several barriers within the healthcare system in the developing world hinder the adoption of home-based patient management, hence the need for the IoMT, whose application raises security concerns, particularly in authentication. Several authentication techniques have been proposed; however, they lack a balance of security and usability. This paper proposes a Naive Bayes based adaptive user authentication app that calculates the risk associated with a login attempt on an Android device for elderly users, using their health conditions, risk score, and available …

Green Data Centers: Sustainable Practices For Energy-Efficient It Infrastructure, Onyinyechukwu Chidolue, Peter Efosa Ohenhen, Aniekan Akpan Umoh, Bright Ngozichukwu, Victoria Adetomilola Fafure, Kenneth Ifeanyi Ibekwe

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The digital age has led to a surge in connectivity, innovation, and information exchange, but it has also led to escalating energy consumption by data centers. Green data centers have emerged as a transformative solution, embodying a commitment to sustainability through eco-friendly practices and cutting-edge technologies. Key principles of green data centers include energyefficient hardware, renewable energy integration, advanced cooling systems, and resource optimization strategies. Energy-efficient hardware involves replacing outdated servers, storage systems, and network equipment with energy-efficient alternatives, such as virtualization technologies. This reduces power consumption and sets the stage for a more sustainable and technologically advanced data center …

Potential Of Lignocellulosic Fiber Reinforced Polymer Composites For Automobile Parts Production: Current Knowledge, Research Needs, And Future Direction, Abdulrahman Adeiza Musa, Azikiwe Peter Onwualu

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In recent years, there has been a notable surge in research focusing on the use of natural fiber-reinforced polymer composites (NFRPCs) in the automobile industry. These materials offer several advantages over their synthetic counterparts, including lightweight properties, renewability, cost-effectiveness, and environmental friendliness. This increasing research interest in NFRPCs within the automotive sector is primarily aimed at overcoming the challenges that have thus far limited their industrial applications when compared to conventional synthetic composites. This paper provides a comprehensive overview of the potential applications and sustainability of lignocellulosic-based NFRPCs in the automobile industry. It examines the current state of knowledge, identifies …

Response Of Species To The Impact Of Climate Change In The Gum Arabic Belt, Sudan: A Case Study In Acacia Senegal, Fatima Awadalla Abass Elhassan, Edouard Konan Kouassi, Haftu Abrha, Ahmed Laamarni, Ahmed Ali Hassabelkareem Siddig

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Sustainable management strategies of trees are important for indigenous agroforestry plant species, such as Acacia. Senegal (A. Senegal), due to the impacts of rapid population growth, land use and climate change. The objective of this investigation was to predict the spatio-temporal distribution of A.senegal in the Gum Arabic belt in Sudan in current (1985–2000) and future climate scenarios (2021–2100). Bioclimatic data was used for modeling purposes utilizing Maxent, with the assessment of model precision conducted through the utilization of the Area Under the Curve (AUC) and shown a high goodness-of-it (AUC=0.905±0.003 ). Significant differences were shown in species distribution between …

Two Decades Of Land Cover Change And Anthropogenic Pressure Around Bontioli Nature Reserve In Burkina Faso, Issaka Abdou Razakou Kiribou, Kangbéni Dimobe, Lassane Yameogo, Huiyi Yang, Truly Santika, Sintayehu W. Dejene

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Protected areas (PAs) are critical for ecosystem maintenance and providing services that benefit both wildlife and people. Nevertheless, climate change and anthropogenic pressures are posing an increasing challenge. Surrounded by high human population densities, there is still a paucity of information on how the land cover in Burkina Faso's PAs is changing, and what kinds of human activities are the main drivers. In this study, we examined the change in land use and land cover (LULC) in the Bontioli Nature Reserve (NR), one of Burkina Faso's most important protected areas, and assessed anthropogenic pressure within and around. Landsat imagery (ETM+ …

Three Decades Of Research Efforts On The Uses, Conservation, And Management Of Cola Nitida (Vent.): State Of Knowledge And Prospects In Africa, Isabelle Erhudice Tachégnon Tokannou, Souleymane Sanogo, Juliano S.H Houndonougbo, Kolawolé Valère Salako, Adandé Belarmain Fandohan

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Cola nitida is a key multipurpose fruit tree species widely distributed across African countries. Several studies have investigated different aspects of the species, but there is a lack of synthesis on the current state of available literature and prospects for sustainable conservation and management of the species. Using the PRISMA approach for systematic review over the last three decades (1990–2022) in Africa, this study gathered key existing research findings on C. nitida. A total of 280 scientific publications were finally retained for this review. Several studies were focused on the socio-economic importance of the species (n = 139 …

Choice Modelling Of Ecooking Adoption By Households In Ghana, Rejoice Ntiriwaa Ossei-Bremang, Fabian Chidubem Eze, Kwame Anane-Fenin, Francis Kemausuor

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The use of electric cooking appliances, also referred to as eCooking devices, presents a practical and
sustainable solution for achieving universal access to clean cooking facilities by 2030. A choice modelling
analysis on the factors that influence the selection of an eCooker in Ghana has been conducted to facilitate
market expansion for organisations seeking to offer clean cooking services. The study utilised Analytical
Hierarchy Process (AHP), Fuzzy-TOPSIS, and Data Envelopment Analysis (DEA) methodologies to assess and
rank electric cookers based on crucial factors such as kWh consumption rate, cooking efficiency, affordability,
time-saving features, ergonomics, space utilisation capabilities, compatibility with cookware …

Microbiological Contamination Of Lettuce (Lactuca Sativa) Reared With Tilapia In Aquaponic Systems And Use Of Bacillus Strains As Probiotics To Prevent Diseases: A Systematic Review, Angelica Adiacao Jossefa, Leonildo Dos Anjo Viagem, Brunno Da Silva Cerozi, Sebastian Wilson

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Aquaponic systems are food production systems that combine aquaculture and hydroponic in a closed recirculation system where water provides nutrients to plants while plants purify water for fish. In this system, tilapia is the most commonly cultured fish and can be easily integrated with vegetable cultivation. However, tilapia host a diverse microbiota some of which are pathogenic and can infect humans. Previous studies have reported contamination of lettuce by pathogenic bacteria which can cause human diseases. Thus, there is an urgent need to employ effective methods to control those bacteria, and Bacillus strains have been successfully used in this context. …

Spatial Analysis Of Livestock Disease Data In Sub-Saharan Africa: A Scoping Review, Alfred Ngwira, Samuel Manda, Esron Daniel Karimuribo, Sharadhuli Iddi Kimera, Christopher Stanley

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Background

Methods

Genomic Diversity And Geographic Distribution Of Newcastle Disease Virus Genotypes In Africa: Implications For Diagnosis, Vaccination, And Regional Collaboration, Charlie Frank Arthur N'Guessan Amoia, Jean N. Hakizimana, Augustino A. Chengula, Muhammad Munir, Gerald Misinzo, James Weger-Lucarelli

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The emergence of new virulent genotypes and the continued genetic drift of Newcastle disease virus (NDV) implies that distinct genotypes of NDV are simultaneously evolving in different geographic locations across the globe, including throughout Africa, where NDV is an important veterinary pathogen. Expanding the genomic diversity of NDV increases the possibility of diagnostic and vaccine failures. In this review, we systematically analyzed the genetic diversity of NDV genotypes in Africa using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Information published between 1999 and 2022 were used to obtain the genetic background of different genotypes of NDV …

Phylogenetic Analysis Of Virulent Strains Of The Newcastle Disease Virus Isolated From Deceased Chickens In Tanzania’S Morogoro And Iringa Regions, Charlie Frank Arthur N'Guessan Amoia, Jean N. Hakizimana, Augustino A. Chengula, Mariam R. Makange, James Weger-Lucarelli, Gerald Misinzo

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Background

Newcastle disease (ND) is a viral disease affecting a wide range of bird species and has a considerable financial impact on the world's poultry market. The ND virus (NDV) strains currently circulating in poultry throughout Africa, and especially in East Africa, exhibit significant genetic variation.

Objectives

The primary objective of the present investigation was to investigate the NDV genotypes in chickens raised in backyards in Tanzania's Morogoro and Iringa districts, which were associated with ND outbreaks.

Methods

Two tissue samples from chickens taken during a suspected ND outbreak in Tanzania's Morogoro (Eastern zone) and Iringa (Southern highlands zone) were …

Seroprevalence And Risk Factors Of Brucellosis In Pastoralists And Their Livestock In Central Equatoria State, South Sudan, Emmanuel Philip Lasuba Lita, Erneo B. Ochi, Gerald Misinzo, Henriette Van Heerden, Robab Katani, Jacques Godfroid,, Coletha Mathew

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Brucellosis poses serious public health implications and substantial economic losses in pastoral rural settings in South Sudan. In humans, brucellosis is almost always originating from animals. Current literature provides scant data regarding the seroprevalence of brucellosis in South Sudan. This cross-sectional study investigates the seroprevalence of brucellosis among the pastoral community and livestock and identifies risk factors for the disease from two Counties, Terekeka and Juba in Central Equatoria State (CES), South Sudan.

Development Of Nanobodies Against The Coat Protein Of Maize Chlorotic Mottle Virus, Faith Njeri Njeru, Olivier Zwaenepoel, Geert Haesaert, Kris De Jonghe, Jan Gettemans

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Maize lethal necrosis (MLN) is a maize disease caused by the maize chlorotic mottle virus (MCMV), a potyvirus which causes yield losses of 30–100%. The present study aimed to isolate nanobodies against the MCMV coat protein (CP) for the diagnosis of MLN. MCMV CP expressed in Escherichia coli was used for llama immunization. VHH (i.e. variable heavy domain of heavy chain) gene fragments were prepared from blood drawn from the immunized llama and used to generate a library in E. coli TG1 cells. MCMV specific nanobodies were selected by three rounds of phage display and panning against MCMV CP. The …

Can High-Value Markets Ensure Households Food Security? Evidence From Avocado Producers In Sidama Region Of Ethiopia, Zerhun Zerhun Zerhun, Kehabtimer Kebede, Aneteneh Ashebir, Zerhun Ganewo, Abera Alemu, Andachew Samuel

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Linking farmers to high-value markets continue to be a viable option for breaking the food insecurity. Many studies have emphasized on factors determining smallholders’ participation in high-value markets. Previous studies have methodological limitations since they neglected the associated effects on food security. Therefore, the purpose this study was to fill a knowledge gap by investigating the factors influencing smallholder avocado farmers’ participation in high-value markets and how it impacts households’ food security in the Aleta chuko district, Ethiopia. The primary data was collected from randomly selected 389 avocado producers using a semi-structured questionnaire. Descriptive statistics, inferential statistics, and propensity score …

In Vitro Studies Of The Antimicrobial Properties And Qualitative Phytochemical Analysis Of Selected Chadian Medicinal Plants, Hissein Hassan Abdel-Razakh, Gaymary George Bakari, Cheol-Ho Pan, Abubakar Shaaban Hoza

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The aim of this study was to evaluate the antimicrobial potential and perform the phytochemical screening of ethanolic (70%) leaf extracts of Bauhinia rufescens and Ocimum basilicum and root extracts of Salvadora persica, three plants used for the treatment of numerous diseases in Chad. The extraction of the plants was made in a ratio of 70% volume of ethanol against 30% volume of distilled water. The yields obtained in the extraction of the leaves of Bauhinia rufescens, Ocimum basilicum, and Salvadora persica roots were respectively 20, 17, and 8.8%. With the disc diffusion method, the results of the antimicrobial assessment …

Trypanocide Use And Molecular Characterization Of Trypanosomes Resistant To Diminazene Aceturate In Cattle In Northern Côte D’Ivoire, Jean-Yves Ekra, Eliakunda Mi Michael Mafie, Henri Sonan, Michael Kanh, Biégo Guillaume Gragnon, Edouard K. N’Goran, Jagan Srinivasan

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The resistance of trypanosomes to the doses of trypanocide administered by farmers to theiranimals acts as a real brake on efforts to control to combat African trypanosomiasis. Thus, in-depthknowledge of the use of these different molecules and their resistance profiles will be necessary toestablish an integrated strategy to combat African trypanosomiasis. To achieve these objectives, aparticipatory survey among farmers and a resistance diagnosis of trypanosome strains identifiedin three regions of northern Côte d’Ivoire (Bagoué, Poro and Tchologo) was carried out using thePCR-RFLP technique, followed by sequencing of genes of interest. This study made it possible toidentify three molecules that are …

Determinants Of The Share Of The Economy Contributed By The Forestry Industry In Ghana From 1975 To 2023, Kwabena Asomanin Anaman, Samuel Ampomah, Joseph Manzvera

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The macroeconomic determinants of the share of the economy contributed by the forestry industry in Ghana were examined over the period from 1975 to 2023, based on the development of time-series cointegration and error correction models. The analysis indicated that the share of the forestry industry was positively influenced by the real value of the cocoa industry, the exchange rate, and the real interest rate. The relationship between the forestry industry's share and per capita real gross domestic product (GDP) was found to be curvilinear: at low levels of per capita income, the share of the forestry industry in the …

Effect Of Soybean And Seaweed-Based Diets On Growth Performance, Feed Utilization, And Gut Microbiota Of Tilapia: A Systematic Review And Meta-Analysis, Leonildo Dos Anjo Viagem, Jean Nepomuscene Hakizimana, Cyrus Rumisha, Brunno Da Silva Cerozi, Gerald Misinzo

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Tilapia, a significant aquaculture species globally, relies heavily on feed for its production. While numerous studies have investigated the impact of soybean and seaweed-based diets on tilapia, a comprehensive understanding remains elusive. This review aimed at evaluating and synthesizing the existing literature on these diets’ effects, focusing on growth performance, feed utilization, and gut microbiota. A systematic search of databases was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and a total of 57 studies were included in the qualitative analysis and 24 in the meta-analysis. The results indicated that soybean-based diets, at a 59.4% inclusion …

Analysis Of Mushroom Consumption And Its Determinants In Ghana, Saani Nassam Iddrisu, Akwasi Akwasi Mensah-Bonsu, Irene Susana Egyir

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Mushroom cultivation in Ghana has gained some modest success due to increased consumption especially by urban dwellers. However, commercial cultivation is still low in the country. The conception of this study is that higher levels of mushroom consumption will boost production in the country. The study analysed mushroom consumption and its influencing factors in Ghana. A multi stage sampling technique was used to collect data from 550 households. The data was collected using a well-structured questionnaire. Descriptive statistics and ordered probit model were used to analyze the frequency of mushroom consumption and the determinants of mushroom consumption respectively. The results …

Enhancing Sustainable Crop Production Through Integrated Nutrient Management: A Focus On Vermicompost, Bio-Enriched Rock Phosphate, And Inorganic Fertilisers – A Systematic Review, Tamara Jose Sande, Hamis J. Tindwa, Alessandra Mayumi Tokura Alovisi, Johnson M. Semoka

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Securing a consistent food supply remains a pressing global challenge, particularly for small-scale farmers grappling with obstacles in enhancing agricultural yields, especially in tropical soils. Integrated Nutrient Management (INM) techniques, employing organic manures like vermicompost and bioenriched rock phosphate, emerge as recommended solutions. Vermicompost is lauded for its nutrient richness and positive soil health impacts. At the same time, bio-enriched rock phosphate serves as a sustainable alternative to conventional phosphorus fertilisers, specifically tailored for tropical soil conditions. Despite individual studies assessing the effects of vermicompost, bio-enriched rock phosphate, and soluble fertilisers on plant growth, a comprehensive overview of their combined …

Insights On The Microbiology Of Ethiopian Fermented Milk Products: A Review, Tiruha Habte Karssa

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Fermented milk products play a vital role in the diets of Ethiopians. They are produced from either spontaneous fermentation or back-slopping methods at the household level, in which lactic acid bacteria (LAB) and yeasts predominate. As a result, the processing steps are not standardized and overall safety is still of public health relevance. Therefore, quality and safety improvement, standardization of traditional manufacturing practices, and commercialization of products to a wider market are important. Hence, this systematic review aimed to provide a comprehensive overview of the microbiology of traditional Ethiopian fermented milk products, including ergo (spontaneously fermented whole milk), dhanaan (fermented …

Rapid Detection Of Mutations In Csf-Cftna With The Genexus Integrated Sequencer, Srividya Arjuna, Mauli Shah, Antonio Dono, Luis Nunez-Rubiano, Pavel S Pichardo-Rojas, Jay-Jiguang Zhu, Roy F Riascos, Rajyalakshmi Luthra, Sinchita Roy-Chowdhuri, Dzifa Duose, Daniel H Wang, Frederick F Lang, Yoshua Esquenazi, Leomar Y Ballester

Faculty, Staff and Student Publications

PURPOSE: Genomic alterations are fundamental for molecular-guided therapy in patients with breast and lung cancer. However, the turn-around time of standard next-generation sequencing assays is a limiting factor in the timely delivery of genomic information for clinical decision-making.

METHODS: In this study, we evaluated genomic alterations in 54 cerebrospinal fluid samples from 33 patients with metastatic lung cancer and metastatic breast cancer to the brain using the Oncomine Precision Assay on the Genexus sequencer. There were nine patients with samples collected at multiple time points.

RESULTS: Cell-free total nucleic acids (cfTNA) were extracted from CSF (0.1-11.2 ng/μl). Median base coverage …

Gut Microbiome And Hepatic Transcriptomic Determinants Of Hcc Development In Mice With Metabolic Dysfunction-Associated Steatohepatitis, Lillian I Dolapchiev, Kristyn A Gonzales, Lorenzo R Cruz, Mihai Gagea, Heather L Stevenson, Suet-Ying Kwan, Laura Beretta

Faculty, Staff and Student Publications

Purpose: Hepatocellular carcinoma (HCC) related to metabolic dysfunction-associated steatotic liver disease (MASLD) is often diagnosed at a late stage, and its incidence is increasing. Predictive biomarkers are therefore needed to identify individuals at high risk of HCC. We aimed to characterize the gut microbiome and hepatic transcriptome associated with HCC development in female mice with hepatocyte-deletion of Pten (HepPten -). These mice present with large variations in HCC development, making them a powerful model for biomarker discovery.

Methods & results: Sequencing of stool 16S and hepatic RNA was performed on a first set of mice. Among all liver histology …

Usp22 Overexpression Fails To Augment Tumor Formation In Mmtv-Erbb2 Mice But Loss Of Function Impacts Mmtv Promoter Activity, Xianghong Kuang, Andrew Salinger, Fernando Benavides, William J Muller, Sharon Y R Dent, Evangelia Koutelou

Faculty, Staff and Student Publications

The Ubiquitin Specific Peptidase 22 (USP22), a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) histone modifying complex, is overexpressed in multiple human cancers, but how USP22 impacts tumorigenesis is not clear. We reported previously that Usp22 loss in mice impacts execution of several signaling pathways driven by growth factor receptors such as erythroblastic oncogene B b2 (ERBB2). To determine whether changes in USP22 expression affects ERBB2-driven tumorigenesis, we introduced conditional overexpression or deletion alleles of Usp22 into mice bearing the Mouse mammary tumor virus-Neu-Ires-Cre (MMTV-NIC) transgene, which drives both rat ERBB2/NEU expression and Cre recombinase activity from the MMTV promoter resulting …

Protection Against Fibrosis By A Bacterial Consortium In Metabolic Dysfunction-Associated Steatohepatitis And The Role Of Amino Acid Metabolism, Suet-Ying Kwan, Kristyn A Gonzales, Mohamed A Jamal, Heather L Stevenson, Lin Tan, Philip L Lorenzi, P Andrew Futreal, Ernest T Hawk, Joseph B Mccormick, Susan P Fisher-Hoch, Robert R Jenq, Laura Beretta

Faculty, Staff and Student Publications

The gut microbiota drives progression to liver fibrosis, the main determinant of mortality in metabolic dysfunction-associated steatohepatitis (MASH). In this study, we aimed to identify bacterial species associated with protection against liver fibrosis in a high-risk population, and test their potential to protect against liver fibrosis in vivo. Based on stool shotgun metagenomic sequencing of 340 subjects from a population cohort disproportionally affected by MASH, we identified bacterial species from the Bacteroidales and Clostridiales orders associated with reduced risk of liver fibrosis. A bacterial consortium was subsequently tested in a mouse model of MASH, which demonstrated protective effects against …

Contrastive Learning With Transformer For Adverse Endpoint Prediction In Patients On Dapt Post-Coronary Stent Implantation, Fang Li, Zenan Sun, Ahmed Abdelhameed, Tiehang Duan, Laila Rasmy, Xinyue Hu, Jianping He, Yifang Dang, Jingna Feng, Jianfu Li, Yichen Wang, Tianchen Lyu, Naomi Braun, Si Pham, Michael Gharacholou, Delisa Fairweather, Degui Zhi, Jiang Bian, Cui Tao

Faculty, Staff and Student Publications

Background: Effective management of dual antiplatelet therapy (DAPT) following drug-eluting stent (DES) implantation is crucial for preventing adverse events. Traditional prognostic tools, such as rule-based methods or Cox regression, despite their widespread use and ease, tend to yield moderate predictive accuracy within predetermined timeframes. This study introduces a new contrastive learning-based approach to enhance prediction efficacy over multiple time intervals.

Methods: We utilized retrospective, real-world data from the OneFlorida + Clinical Research Consortium. Our study focused on two primary endpoints: ischemic and bleeding events, with prediction windows of 1, 2, 3, 6, and 12 months post-DES implantation. Our approach first …

Usp22 Overexpression Fails To Augment Tumor Formation In Mmtv-Erbb2 Mice But Loss Of Function Impacts Mmtv Promoter Activity, Xianghong Kuang, Andrew Salinger, Fernando Benavides, William J Muller, Sharon Y R Dent, Evangelia Koutelou

Faculty, Staff and Student Publications

The Ubiquitin Specific Peptidase 22 (USP22), a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) histone modifying complex, is overexpressed in multiple human cancers, but how USP22 impacts tumorigenesis is not clear. We reported previously that Usp22 loss in mice impacts execution of several signaling pathways driven by growth factor receptors such as erythroblastic oncogene B b2 (ERBB2). To determine whether changes in USP22 expression affects ERBB2-driven tumorigenesis, we introduced conditional overexpression or deletion alleles of Usp22 into mice bearing the Mouse mammary tumor virus-Neu-Ires-Cre (MMTV-NIC) transgene, which drives both rat ERBB2/NEU expression and Cre recombinase activity from the MMTV promoter resulting …

Early And Rapid Development Of Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Cell Transplantation, Jacqueline S Dickey, Burton F Dickey, Amin M Alousi, Richard E Champlin, Ajay Sheshadri

Faculty, Staff and Student Publications

Bronchiolitis obliterans (BO) is a form of graft-versus-host disease (GVHD) in the lung and manifests as moderate to severe airflow obstruction after hematopoietic stem cell transplantation (HCT). New-onset airflow obstruction on spirometry is considered diagnostic of bronchiolitis obliterans syndrome (BOS). BOS affects about 5% of all HCT recipients. In general, BO is thought of as a late complication of HCT, usually occurring after day 100 post-transplantation. However, the onset of airflow obstruction can be rapid and is most often irreversible even with treatment. We describe a patient who rapidly developed severe airflow obstruction less than one month after transplantation following …