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Ergot Alkaloid Consumption Alters Serotonin Receptor-Induced Vasoactivity In Ovine Umbilical Vasculature, James L. Klotz, Jessica L. Britt, Maslyn A. Greene, Coral Kent-Dennis, Susan K. Duckett

Animal and Food Sciences Faculty Publications

Consumption of ergot alkaloids during the second half of gestation has been shown to decrease umbilical artery vasoactivity resulting in decreased birth weights. Negative vascular effects of ergot alkaloids are mediated predominantly through serotonergic and adrenergic receptors in other tissues. Vasoactivity of serotonin (5-HT) receptors 5-HT_2A and 5-HT_1B/1D in umbilical artery and vein from ewes receiving endophyte-infected seed (E + 1.77 mg ergovaline/hd/d) or a control total mixed ration (CON; 0 mg ergovaline/hd/d) tall fescue seed at d-110 and d-133 of gestation was evaluated. Gravid reproduction tracts were collected from ewes. Two-mm sections of umbilical artery and vein …

Effect Of Chronic Cyclic Heat Stress And Supplemented Inorganic And Organic Zinc Source Levels On Grow-Finish Pig Growth Performance And Estimated Body Composition, Kayla M. Mills, Julie A. Mahoney, Alan W. Duttlinger, Sarah K. Elefson, John S. Radcliffe, Zachary J. Rambo, Brian T. Richert

Animal and Food Sciences Faculty Publications

Zinc (Zn) supplementation has proved to mitigate the effects of heat stress with varying effects evident with Zn source during acute heat events. However, the effects of Zn supplementation during long-term summer weather patterns have yet to be explored. Therefore, the objective of this study was to identify the effects of supplementation source and level of Zn to mitigate the negative effects of long-term, cyclic heat stress in finishing swine. Six hundred cross-bred pigs were housed under thermoneutral (TN) or cyclic heat (HS) conditions simulating summer heat with acute 3-d heat waves for a 70-d study. Thermoneutral conditions were 16.7 …

Effects Of Increasing Dietary Arginine Supply During The Three First Weeks After Weaning On Pig Growth Performance, Plasma Amino Acid Concentrations, And Health Status, Jorge Y. Perez-Palencia, Christian D. Ramirez-Camba, Keith Haydon, Kristine L. Urschel, Crystal L. Levesque

Animal and Food Sciences Faculty Publications

A total of 425 weaned pigs (Exp. 1: 225 pigs [5.8 ± 0.9 kg]; Exp. 2: 200 pigs [6.1 ± 1.2 kg]) were used to determine the optimal dietary standardized ileal digestible (SID) arginine (Arg) level in early nursery diets based on growth and health responses. The basal diet in Exp.1 was formulated to meet SID Arg recommendation (0.66%; NRC, 2012) and in Exp. 2, SID Arg was set to simulate current industry practices for feeding nursery pigs (1.15 %). Basal diets were supplemented with 0.3%, 0.6%, 0.9%, and 1.2% of l-arginine to provide five levels of dietary SID Arg. …

Essential Oil Supplementation Improves Insulin Sensitivity And Modulates The Plasma Metabolome Of Hyperinsulinemic Horses, Caroline M.M. Loos, Shuang Zhao, Liang Li, Janet Li, Wei Han, Eric S. Vanzant, Kyle R. Mcleod

Animal and Food Sciences Faculty Publications

The objective of this study was to investigate the effect of essential oil (EO) supplementation on insulin sensitivity (IS) and the plasma metabolome in insulin dysregulated (ID) horses. Horses were blocked by degree of IS and assigned randomly to treatment: oral daily bolus (50 mL) of either a plant derived EO supplement or carrier (CON). Mares were housed in dry lots with ad libitum access to grass hay and supplemented individually twice daily with a concentrate to meet nutrient requirements for mature horses. Before and after 6 wks of treatment, mares underwent a combined glucose-insulin tolerance test (CGIT) and an …

Ovotransferrin-Depleted Egg White Hydrolysate Reduces Blood Pressure In Spontaneously Hypertensive Rats, Fatemeh Ashkar, Hongbing Fan, Zihan Wang, Ilekuttige Priyan Shanura Fernando, Jianping Wu

Animal and Food Sciences Faculty Publications

Egg whites contain a variety of biologically active proteins and are a good source of bioactive peptides. Egg white hydrolysate prepared by thermoase (EWH) possesses antihypertensive effects. Our recent study showed that egg white proteins, after depleting ovotransferrin, also contained many angiotensin-converting enzyme (ACE)-inhibitory peptides after hydrolysis using thermoase. In the present study, we aimed to explore the antihypertensive effect of the ovotransferrin-depleted egg white hydrolysate prepared by thermoase (OD-EWH) in spontaneously hypertensive rats, using EWH as the reference. The animals were orally administered with either hydrolysate at a dose of 1 g/kg body weight/d over 9 d. OD-EWH treatment …

Effects Of A Second Iron-Dextran Injection Administered To Piglets During Lactation On Differential Gene Expression In Liver And Duodenum At Weaning, James L. Pierce, J. Wesley Lyons, Tyler B. Chevalier, Merlin D. Lindemann

Animal and Food Sciences Faculty Publications

Six female littermate piglets were used in an experiment to evaluate the mRNA expression in tissues from piglets given one or two 1 mL injections of iron dextran (200 mg Fe/mL). All piglets in the litter were administered the first 1 mL injection < 24 h after birth. On day 7, piglets were paired by weight (mean body weight = 1.72 ± 0.13 kg) and one piglet from each pair was randomly selected as control (CON) and the other received a second injection (+Fe). At weaning on day 22, each piglet was anesthetized, and samples of liver and duodenum were taken from the anesthetized piglets and preserved until mRNA extraction. differential gene expression data were analyzed with a fold change cutoff (FC) of |1.2| P < 0.05. Pathway analysis was conducted with Z-score cutoff of P < 0.05. In the duodenum 435 genes were significantly changed with a FC ≥ |1.2| P < 0.05. In the duodenum, Claudin 1 and Claudin 2 were inversely affected by + Fe. Claudin 1 (CLDN1) plays a key role in cell-to-cell adhesion in the epithelial cell sheets and was upregulated (FC = 4.48, P = 0.0423). Claudin 2 (CLDN2) is expressed in cation leaky epithelia, especially during disease or inflammation and was downregulated (FC = -1.41, P = 0.0097). In the liver, 362 genes were expressed with a FC ≥ |1.2| P < 0.05. The gene most affected by a second dose of 200 mg Fe was hepcidin antimicrobial peptide (HAMP) with a FC of 40.8. HAMP is a liver-produced hormone that is the main circulating regulator of Fe absorption and distribution across tissues. It also controls the major flows of Fe into plasma by promoting endocytosis and degradation of ferroportin (SLC4A1). This leads to the retention of Fe in Fe-exporting cells and decreased flow of Fe into plasma. Gene expression related to metabolic pathway changes in the duodenum and liver provides evidence for the improved feed conversion and growth rates in piglets given two iron injections preweaning with contemporary pigs in a companion study. In the duodenum, there is a downregulation of gene clusters associated with gluconeogenesis (P < 0.05). Concurrently, there was a decrease in the mRNA expression of genes for enzymes required for urea production in the liver (P < 0.05). These observations suggest that there may be less need for gluconeogenesis, and possibly less urea production from deaminated amino acids. The genomic and pathway analyses provided empirical evidence linking gene expression with phenotypic observations of piglet health and growth improvements.

Role Of Ε-Poly-Lysine In Mixed Surimi Gel, Zhaorui Li, Guangcan Liang, Yungang Cao, Fang Yuan, Miaomiao Liu, Zelong Liu, Youling L. Xiong

Animal and Food Sciences Faculty Publications

The effects of different concentrations of ε-Poly-lysine (ε-PL: 0.005%, 0.01%, 0.02%, 0.04%, and 0.06%) on the marine fish-egg white protein compound gels, treated with 0.4% TGase induced cross-linking were systematically investigated under low salt and phosphorus-free conditions (0.5% NaCl). The results showed the combination of ε-PL and TGase had a synergistic effect on improving sectional gel properties of composite surimi samples. Wherein the rheological, LF-NMR, and SEM results confirmed that the addition of ε-PL based on 0.4% TGase significantly improved the gel strength (to the highest value: 781.63 g·cm), apparent viscosity, and G 'value of the composite surimi sample, as …

Social Networks As Predictors Of Musculoskeletal Injury In U.S. Army Soldiers (Snap-Mski), Kristen L. Zosel

Theses and Dissertations

INTRODUCTION: Musculoskeletal injuries (MSKIs) are the leading cause of medical non-readiness among U.S. Army Soldiers, costing the Military Health System an estimated $4.7 billion annually in direct and indirect costs. Current MSKI mitigation efforts focus on individual attributes such as body mass index and gender. However, emerging research highlights the significance of social ties on health outcomes and behaviors. This study examined the patterns of MSKI within military social networks and how social interactions, along with health behaviors such as sleep, physical activity (PA), and diet, co-occur in Soldiers with and without MSKI. METHODS: Phase 1 involved a cross-sectional sociocentric …

California Carbon Sequestration And Carbon Dioxide Pipeline Regulation In An Era Of Climate Change: Technology And Policy, Robert A. Mason

Master's Projects

This report serves primary purpose of finding prospective policies that could be useful in CARB’s new carbon sequestration program as mandated by S. B. 905. The bill states program goals and provides several objectives that direct the California Natural Resources Agency (CNRA), the California Air Resource Board (CARB), and the California Geological Survey (CGS, or just Survey) with various responsibilities. Curiously, S.B. 905 does not mention the Office of State Fire Marshal (OSFM or CalFire), although it has primary responsibility for issuing permits for hazardous pipelines as an agent of the federal Pipelines and Hazardous Materials Safety Administration (PHMSA).

Pipelines …

Adaptive Metric-Driven Load Balancing For Specialized Clusters Using Nginx, Juhi Raju Malkani

Master's Projects

Adaptive Metric-Driven Load Balancer is an innovative two-tier load-balancing system that uses NGINX and Prometheus to optimize resource allocation in specialized cloud clusters. This framework is built to give great performance and flexibility and runs on Google Kubernetes Engine (GKE), but it may also be deployed on local cloud environments for added security. The first tier of our system uses an NGINX-based load balancer to route incoming requests based on content type, sending traffic to hardware-optimized clusters for processing requests through specialized hardware. In our algorithm, the second tier dynamically modifies load distribution throughout each cluster by calculating pod weights …

Embracing Mindfulness-Based Professional Development In Early Childhood Education, Drew Giles

Dissertations

There is a growing need for school districts to identify additional strategies to support the work-related stress and emotional labor ingrained in an early educator’s career. By orienting early childhood education (ECE) staff to mindfulness practices, education leaders may identify new approaches to assist early childhood educators’ well-being, building healthy work atmospheres, and activities to shift the culture in early childhood settings. This study employs a qualitative exploratory research design, specifically video documentary methodology to better understand how early childhood educators experience a mindfulness-based professional development (MBPD) program designed for ECE staff, explore what they say education leaders should know …

Neural Hyperactivity During Value-Based Decision-Making In People With Daily/Near Daily Cannabis Use, Miranda Ramirez

Theses and Dissertations--Psychology

Value-based decision-making involves the coordinated effort of multiple brain regions to guide future choices based on past experiences. These processes are disrupted in cannabis use disorder, where individuals continue to use cannabis despite negative consequences. Reinforcement learning (RL) paradigms can be used to capture changes in the value of available options and may inform how the brain is impacted by frequent cannabis use. This study combined fMRI with behavioral modeling of probabilistic choice task data to compare value-based choices between young adults reporting daily/near daily cannabis use (CAN) and controls (CTRL). Participants selected one of two options reinforced ($0.25) at …

Effect Of A Brief Coping Intervention On Activity Of Target Organs Of The Sympathetic And Parasympathetic Nervous Systems During Stress, Kyle P. Rawn

Theses and Dissertations--Psychology

Stress is a critical aspect of the human experience and how an individual responds to stress can shape future outcomes, such as physical and mental health, as well as shape the patterns of stress responding that persist throughout one’s lifespan. Coping is a central element of stress responding and can strongly influence the outcome of the stress process. Successful coping can alleviate stress, but ineffective coping may lead to less-than-optimal responding. For example, aspects of the biological stress response, such as activity of target organs for the sympathetic and parasympathetic nervous systems, have important implications for future susceptibility to health …

Influence Of Oral Contraceptives On Alcohol Use In Young Adult Women, Ashley Strzelecki

Theses and Dissertations--Psychology

Rates of heavy drinking and Alcohol Use Disorder are rising dramatically in young adult women, making it important to better understand female-specific risks for problematic drinking. Circulating levels of ovarian hormones are one potential mechanism influencing alcohol use in women. Many young adult women use oral contraceptives (OCs) that alter endogenous hormone levels, and little is known about how OCs and the synthetic hormones they contain may influence alcohol use. This dissertation consists of three studies that investigated alcohol consumption in women using OCs and explored potential mechanisms through which OCs may influence alcohol use. Study 1 compared self-reported alcohol …

It Takes A Village: Impact Of Lgbtq+ Community On The Relationship Between Parenting Stress, Parent Mental Health, And Child Adjustment, Kevin Mcaweeney

Theses and Dissertations--Psychology

While LGBTQ+ parented families are largely the same as their cis-het parent counterparts, they still experience unique factors exclusive to them. One such factor is access to the LGBTQ+ community. While research has emphasized the importance of community within the family system, the role the LGBTQ+ community can play for LGBTQ+ parented families is largely unexplored. Additionally, LGBTQ+ research examining parents of adolescents is similarly lacking. Utilizing a sample of LGBTQ+ parents with adolescent children, and informed by ecological systems theory, self-determination theory, and the parenting stress model, I examine the influence parent’s sense of LGBTQ+ community has on the …

Relationship Of Criterion A Level Of Personality Functioning With Borderline Personality Disorder Over The Course Of Brief Treatment, Michelle M. Smith

Theses and Dissertations--Psychology

The Alternative Model of Personality Disorders (AMPD) housed within DSM-5 Section III posits that impairments in personality functioning, operationalized by the Level of Personality Functioning Scale (LPFS) “constitute the core of personality psychopathology” (APA, 2013, p. 762). If this is the case, there should be strong associations between LPFS and DSM personality disorders, including borderline personality disorder (BPD). BPD Compass is a comprehensive CBT-based treatment for BPD which aims to reduce BPD symptoms over the course of 18 weekly sessions. This study examined if a) LPFS would be associated with changes in BPD symptoms, b) whether LPFS has incremental validity …

Factors That Contribute To Perceptions Of Police-Civilian Interactions, Shelby Wynne

Theses and Dissertations--Psychology

Perceptions of police-civilian interactions have been found to be impacted by the perspective in which they are viewed, with first-person perspectives eliciting negative perceptions of civilians and positive perceptions of police. However, the nature of the relationship between race and camera-perspective has not been fully explored. Black people are more likely to harmed by police at a disproportionate rate compared to White people, and consequently, have more negative perceptions of police. Three studies investigated what factors informed perceptions of police encounters, particularly when camera perspectives differed. Results showed partial support for my prediction that Black people are as not susceptible …

The Experience And Regulation Of Posttraumatic Shame Among Women With Interpersonal Trauma Histories, Jordyn M. Tipsword

Theses and Dissertations--Psychology

Posttraumatic shame – an emotion stemming from harsh attitudes about the self after trauma – is central to PTSD for many women following physical or sexual assault or abuse (interpersonal trauma [IPT]). However, knowledge of the frequency, intensity, and stability of shame in the daily lives of women post-IPT is lacking. Additionally, while some work has explored shame-specific emotion regulation (ER), or processes aimed at changing emotional responses, it remains unclear which ER strategies are effective in reducing shame, and the role of PTSD severity in shame regulation also remains unexplored. This project explored daily experiences and regulation of posttraumatic …

Development Of The Trait Response To Emotion Dimensional Measure For Use In Minoritized Populations, Anita Adams

Theses and Dissertations--Psychology

Trait responses to emotion (TREs) are personality traits that develop from how one consistently responds to and copes with emotions. TRE development is influenced by demographic factors, such as age, gender, and early life adversity, and TREs can influence how one copes with a variety of stressors. TRE theory and measurement is relatively new, and although TREs have been validated in majority race samples, TRE theory and measurement have not been validated in minority race samples, particularly in African American populations. This dissertation is taking the first preliminary steps for the development of a cross-cultural trait response to emotion dimensional …

Extracellular Free Water As An Imaging Biomarker Of Neuroinflammation, Cristina N. Pinheiro

Theses and Dissertations--Psychology

Older adults experience a chronic state of heightened immune response referred to as “inflammaging” which can be observed by detecting levels of proinflammatory cytokines in blood serum. These proinflammatory cytokines are secreted in the central nervous system and may also enter the brain through the blood brain barrier. Previous literature has suggested that extracellular free water, a magnetic resonance imaging metric, may allow us to detect alterations in the extracellular space which are thought to correlate with inflammation in the central nervous system. This study examined the correlation between two proinflammatory cytokines, IL-6 and TNFα, collected longitudinally and cross-sectionally imaged …

Hormonal Effects On Adhd Symptoms In Adolescents Across The Menstrual Cycle, Ashley G. Eng

Theses and Dissertations--Psychology

Background: Females with attention-deficit/hyperactivity disorder (ADHD) become particularly impaired during adolescence, experiencing increased rates of depression and anxiety, as well as important public and personal health outcomes like increased suicide attempts, risky sexual behavior, and substance use. However, female-specific risk factors for ADHD have been vastly understudied despite this increased impairment and comorbidity. One particularly understudied risk factor is the dramatically rising and fluctuating levels of ovarian hormones during late puberty that begin cycling monthly. In adult women, rapid decreases in estrogen levels increase risk for ADHD symptoms across the menstrual cycle, particularly for those with high trait impulsivity. Preliminary …

The Effect Of Cytomegalovirus Infection On Daily Stress Processes In Early Adulthood, Elana Gloger

Theses and Dissertations--Psychology

Chronic stress increases risk for disease, poor health, and early mortality. Cytomegalovirus (CMV), a common latent herpes virus, may promote neurological changes that increase vulnerability to chronic stress by way of self-regulatory deficits, though this has yet to be directly tested. Investigating CMV at younger ages is crucial to understand the effect of CMV across the lifespan and identify modifiable health-factors for future anti-aging interventions. The present study aimed to investigate how, and for whom, CMV associates with daily stress processes in early adulthood.

Participants (N = 108, M_age = 19.7, 83.3% female, 72% White) completed an in-person lab …

A Mixed-Methods Study Exploring Free Nicotine Replacement Therapy As A Strategy To Promote Tobacco Treatment Equity At Cancer Center Cessation Initiative Sites, Marguerite A. Webster

Theses and Dissertations--Psychology

Nicotine replacement therapy (NRT) is a safe, efficacious smoking cessation treatment for cancer patients; however, equitable access is limited due to insurance gaps. Offering free NRT to patients with cancer has potential to increase tobacco treatment engagement and promote equity. This mixed-methods study aims to describe how some Cancer Center Cessation Initiative (C3I) sites implemented free NRT within their tobacco treatment programs (TTPs) to inform future development of equitable TTPs. Participating sites’ (N=9) TTP and patient population characteristics were assessed via survey and analyzed with descriptive statistics. Semi-structured interviews were conducted with 16 individuals and analyzed using directed …

Fluctuations In Alcohol Impairment Of Working Memory Across The Menstrual Cycle, William Mcgarrigle

Theses and Dissertations--Psychology

Behavioral endocrinology studies in women suggest that higher circulating levels of the ovarian sex hormone estradiol (E2) may be linked to better working memory performance, especially under conditions of cognitive impairment (e.g., age-related cognitive decline). Phases of the menstrual cycle characterized by different levels of E2 may therefore influence the degree to which women are vulnerable to alcohol impairment of working memory. The current thesis used a within-subjects design to test the hypothesis that women are less sensitive to acute alcohol-induced impairment of working memory when E2 is elevated during the menstrual cycle. A sample of 75 premenopausal women completed …

Disinhibition And Bac Estimation As Predictors Of Risky Driving Behavior While Intoxicated, Sarah Heymsfeld

Theses and Dissertations--Psychology

Alcohol-related driving fatalities persist as a public health problem in the United States. Recent studies have begun focusing on driver risk-taking as a factor in DUI occurrences and consequent driving fatalities. Key factors that could contribute to risky intoxicated driving are a lack of self-awareness concerning intoxication levels and consequent risk in addition to alcohol-induced increases in the driver’s impulsivity. Fifty young adult drivers received 0.65 g/kg of alcohol (target BAC = 80 mg/dl) or a placebo in a counterbalanced order on two different days and performed a simulated driving test that measured driver risk-taking as reduced distance to other …

Power Of Perception: The Role Of Perceived Caregiver Mindset Beliefs On Undergraduate Student Academic Engagement, Katherine R. Tanaka

Theses and Dissertations--Psychology

Promoting academic engagement is vital for college student success. Researchers have explored factors like growth mindset, the belief that intelligence can improve with effort, as a driver of academic engagement. Beyond personal mindset, students’ perceptions of key social influences, such as caregivers, also play a role. This study examined how undergraduate students’ own mindsets and perceptions of their caregivers’ mindsets relate to four components of academic engagement: behavioral and emotional engagement, and behavioral and emotional disaffection. Data from undergraduates (N = 1417) were analyzed using surveys, descriptive statistics, hierarchical regression, and exploratory moderation. Students generally reported both a personal …

Cognitive-Behavioral Effects And Sex Differences In Alcohol Use, Mia Radevski

Theses and Dissertations--Psychology

Addiction models (e.g., iRISA model) suggest that excessive substance use can result in behavioral consequences such as decreased response inhibition and increased salience attribution toward alcohol cues. The primary goal of this project was to explore potential sex differences in these characteristics of addiction. This dissertation is comprised of two separate but related studies. Study 1 investigated sex differences in inhibitory control and attentional bias. The central hypotheses are 1) women who reported heavy-drinking would display greater disruptions in behavioral inhibitory control following alcohol-related cues, 2) men who reported heavy-drinking would display greater attentional bias toward alcohol-related cues, and 3) …

Establishing The Feasibility Of Crowdsourcing To Study Value-Based Decision-Making In Substance Use Disorders, Thomas Shellenberg

Theses and Dissertations--Psychology

Substance use disorders (SUDs) are characterized by repeated choices to use drugs despite adverse consequences. Value-based decision-making theory posits that choices are guided by predicted values of available options which are updated based on outcomes. Computational modeling of reinforcement learning (RL) during choice tasks has shown promise for uncovering latent mechanisms of decision-making. Recruiting people with SUD is difficult, but crowdsourcing offers an alternative for accelerating data collection. However, the validity of computational modeling using online choice task data has not been well-established. This thesis aimed to use the online crowdsourcing platform Prolific to 1) compare online and in-person choice …

Menstrual Cycle Phase And Hormonal Effects On Emotional Eating In Females With Attention-Deficit/Hyperactivity Disorder, Urveesha Nirjar

Theses and Dissertations--Psychology

Previous research has shown that cyclical fluctuations in ovarian hormones can predict changes in ADHD symptoms as well as eating behaviors, particularly emotional eating across the menstrual cycle. Previous studies have so far only examined the effects of estrogen (E2), progesterone (P4) and cycle phase in predicting individual symptoms or disorders such as ADHD or eating disorders or related behaviors separately. The aim of this study is to examine how emotional eating is influenced by naturally occurring hormonal and cycle changes in a sample overrecruited for ADHD. Seventy-eight individuals (assigned female at birth) with menstrual cycles overrecruited for ADHD provided …

Terror And Time: Analyzing Homegrown Terrorism In The United States, Kyser Daniels-Baessler

Theses and Dissertations

The events of September 11th, 2001, prompted a global reckoning with the threat of international terrorism, leading to intensified awareness and policy responses worldwide. However, amidst this heightened global focus, the United States has faced a concerning rise in politically motivated violence on its soil. Against this backdrop, this thesis delves into the phenomenon of homegrown terrorism within the United States from 2000 to 2020. By employing advanced geospatial techniques, this study seeks to pinpoint areas nationwide with elevated rates of homegrown terrorist incidents. Moreover, it endeavors to uncover potential temporal correlations between these acts of violence and significant events, …