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Articles 74431 - 74460 of 80343
Full-Text Articles in Entire DC Network
The Role Of Fibroblast Growth Factor Receptors In Inflammatory Airway Diseases, Molly Easter
The Role Of Fibroblast Growth Factor Receptors In Inflammatory Airway Diseases, Molly Easter
All ETDs from UAB
Chronic inflammation plays a role in the development and progression of airway diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). COPD is caused primarily by chronic cigarette smoke exposure. Conversely, CF is a single gene disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR). Although the causes of COPD and CF are different, there are common pathological features. Studies show that chronic inflammation plays a significant role in the pathogenesis of both COPD and CF. Moreover, chronic inflammation induces ageing-associated pathomechanisms like cellular senescence, which exacerbates chronic inflammation. Previous work demonstrates that …
Non-Catalytic Regulators Of The Secretory Pathway, Peyton Vanwinkle
Non-Catalytic Regulators Of The Secretory Pathway, Peyton Vanwinkle
All ETDs from UAB
This thesis focuses on two key questions: 1) how are bone development and regeneration regulated by the CREB3L1 transcription factor; and 2) what is the mechanism of action of the endoplasmic reticulum resident protein JAGN1, which when dysregulated, causes severe congenital neutropenia (SCN)? CREB3L1 regulates bone development and regeneration in mammalian models by facilitating the expression of COL1A1 and components of the secretory pathway required for collagen secretion. We generated two zebrafish models of Creb3l1 dysfunction (creb3l1ΔbZIP/ΔbZIP and creb3l1TA+/TA+). Both models showed that Creb3l1 functions in regulating col1a1a transcription and overall regenerate size are conserved in zebrafish. However, we also …
Utilization Of Romosozumab During Covid-19 Pandemic Among U.S. Medicare Beneficiaries, Ye Liu
Utilization Of Romosozumab During Covid-19 Pandemic Among U.S. Medicare Beneficiaries, Ye Liu
All ETDs from UAB
Osteoporosis is increasingly recognized as a major public health issue in the aging U.S. population. Shortly after the licensure of romosozumab, an injectable medication indi-cated for women with postmenopausal osteoporosis at high risk of fracture administered by health care provider monthly, the COVID-19 pandemic broke out, which caused ma-jor disruptions to the delivery of health care across the nation. The pandemic dispropor-tionately affected minority and economically disadvantaged communities, exacerbating many pre-existing health disparities. Romosozumab has the highest dosing frequency among common injectable osteoporosis medications in the U.S. that require an office visit for injection, making romosozumab adherence more susceptible to …
Diagnostic Imaging Approaches: Pet Imaging In Monitoring Immune Responses In Oncology And Tuberculosis, Chanelle Hunter
Diagnostic Imaging Approaches: Pet Imaging In Monitoring Immune Responses In Oncology And Tuberculosis, Chanelle Hunter
All ETDs from UAB
Positron emission tomography (PET) imaging agents play a transformative role in personalized medicine through their application in disease diagnosis and immunotherapy monitoring, focusing on chemokine receptors, TH1-activated immune cells, and tuberculosis (TB) diagnostics. In immuno-oncology, accurately assessing TH1-activated immune cells in the tumor microenvironment (TME) is vital for evaluating cancer immunotherapy efficacy. Chemokine receptors, crucial in cellular signaling and inflammatory reactions, play a significant role in TH1 responses, thus serving as a potential area of interest in elucidating these anti-tumor responses. Through our work a novel CXCR3-targeting immunoPET probe, [89Zr]DFO-αCXCR3, was developed to detect and quantify these cells. This probe …
Education Attainment And Health: Outside The Gender Binary, Brianna Patterson
Education Attainment And Health: Outside The Gender Binary, Brianna Patterson
All ETDs from UAB
Transgender and gender nonbinary individuals, hereafter referred to as trans, report worse health outcomes than trans individuals whose gender identity matches their sex assigned at birth, hereafter referred to as cisgender (Bauer, Hammond, Travers et al. 2009, Cicero, Reisner, Merwin et al. 2020). Past research has indicated that social determinants of health, such as education attainment, may be responsible for these inequities (Low 2006, The Lancet Public 2020). Education’s influence on health is well known from previous research, but the association is not distributed equally. In the United States (US) educational system, state and local governments have control, not the …
Crown Fatigue Resistance And Enamel Wear Of 3d Printed Resin Compared To Lithium Disilicate, Pranit Vasant Bora
Crown Fatigue Resistance And Enamel Wear Of 3d Printed Resin Compared To Lithium Disilicate, Pranit Vasant Bora
All ETDs from UAB
Purpose: The purpose of this study is to compare the wear characteristics and fatigue resistance of two dental crown materials: SprintRay Ceramic Crown, a 3D-printed resin material, and IPS™ e.Max CAD, a lithium disilicate material. Methods: This study evaluates wear and fatigue characteristics of dental crowns made from Ceramic Crown (SprintRay) and IPS e.max CAD LT (Ivoclar). For fatigue testing, custom fatigue devices were utilized to subject the crowns to cyclic loading, simulating occlusal forces. The specimens underwent 100,000 cycle intervals until 1.5 million cycles at a load of 40N of fatigue loading, with inspections conducted for signs of debonding, …
Phosphate Drives Pulmonary Inflammation Through Fgfr1, Erk, And Akt Signaling, Seth Bollenbecker
Phosphate Drives Pulmonary Inflammation Through Fgfr1, Erk, And Akt Signaling, Seth Bollenbecker
All ETDs from UAB
Chronic kidney disease (CKD) is characterized as irreversible progressive loss of renal function and affects over one tenth of the global population. Although CKD-associated comorbidities contribute significantly to its mortality, the lungs are often not considered. Lung diseases make up three of the top six leading causes of death worldwide and share many comorbidities with CKD. Clinical reports show that CKD patients are more likely to develop obstructive and restrictive lung diseases, but the mechanisms underlying this propensity for CKD-associated pulmonary complications are unknown. Hyperphosphatemia and associated elevations of fibroblast growth factor (FGF) 23, two of many consequences of reduced …
Screening For And Addressing Social Determinants Of Health In Hospitals Participating In Accountable Care Organizations, Heather Lee
All ETDs from UAB
There is a growing recognition among hospitals, payers, and policymakers in the United States that addressing social needs of patients is important to improving quality of care, patient outcomes, and lowering health care spending. Accountable care organizations (ACOs) may be especially incentivized to address social needs of patients to meet population health goals related to patient outcomes and costs. This cross-sectional study used data from the American Hospital Association Annual Survey to explore to explore how hospitals participating in or leading ACOs are screening for and addressing individual-level HRSNs of patients and to understand the extent to which ACOs are …
Teachers' Perspectives On The Impact Of Interactive Read Aloud Strategies For Comprehension Skills Of Saudi Kindergarten Students: A Mixed Method Study, Riham Alsultan
All ETDs from UAB
Reading comprehension is a very integral element of encouraging lifelong learning amongst kindergarten students. The main objective of this research is to investigate teachers’ perspectives on the effectiveness of interactive read-aloud (IRA) in improving reading comprehension skills amongst kindergarten students in Saudi Arabia. The study's overarching aim was to determine how interactive reading-aloud strategies employed by Saudi kindergarten teachers during interactive read-aloud time impact Saudi kindergarten students' overall comprehension skills through the perceptions of teachers regarding the effectiveness of these strategies. To achieve this objective, the researcher employed a mixed-method research design, a combination of both quantitative and qualitative strategies. …
Genotype And Sex Specific Effects Of Methionine Restriction On The Life And Healthspan Of Drosophila Melanogaster, Joshua Robert Smith
Genotype And Sex Specific Effects Of Methionine Restriction On The Life And Healthspan Of Drosophila Melanogaster, Joshua Robert Smith
All ETDs from UAB
Reduced dietary intake of the amino acid methionine has been reported to significantly extend the lifespan of common laboratory model organisms including Saccharomyces cerevisiae, Mus musculus, and Drosophila melanogaster. Methionine restriction (MR) has also been achieved via non-dietary means such as metabolite supplementation and CRISPR-Cas9 gene editing. MR along with protein and calorie restriction are known as dietary interventions capable of producing pro-longevity benefits through regulation of nutrient sensing pathways. Recent studies in model organisms have also identified beneficial effects of a low methionine diet on aging-associated phenotypes and markers of overall healthspan. However, the effects of this intervention on …
Predictive Modeling Using Clinical Data And Compositional Microbiome Data, Li Zhang
Predictive Modeling Using Clinical Data And Compositional Microbiome Data, Li Zhang
All ETDs from UAB
This dissertation focuses on developing predictive modeling using data from two areas: clinical data and microbiome data. Compositional data in real life are mainly represented by relative proportions. With the advancement of next-generation sequencing (NGS) technology, researchers can now collect a large volume of metagenomic sequencing data, which is valuable for investigating associations between the microbiome and host diseases. Current methods for dealing with such data are either constrained by generalization or limited by application. In the first part, to address this, we propose Bayesian compositional generalized linear models for analyzing microbiome data (BCGLM). This model incorporates a structured regularized …
Characterizing The Reproductive System Of Avrainvillea In HawaiʻI, Brinkley Mikayla Thornton
Characterizing The Reproductive System Of Avrainvillea In HawaiʻI, Brinkley Mikayla Thornton
All ETDs from UAB
Sex has generated incredible life cycle diversity across eukaryotes. Differences in the timing of meiosis and fertilization have generated tremendous variation in the duration of haploid and diploid phases. To understand what drives eukaryotic sexual diversity, there remains a need to determine the rates of sexual and asexual reproduction in natural populations. Moreover, life cycle diversity is predicted to be correlated with the reproductive system. Yet, most studies on reproductive variation have focused on diploid or diploid dominant organisms, hindering the ability to understand sex. Macroalgae can serve as useful models to overcome this limitation via life cycle and reproductive …
The Multifaceted Role Of Neutrophil Heterogeneity In Covid-19 Pathogenesis, Marcus Darrell Davis
The Multifaceted Role Of Neutrophil Heterogeneity In Covid-19 Pathogenesis, Marcus Darrell Davis
All ETDs from UAB
COVID-19 is a respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The disease is characterized by an excessive inflammatory response and dysfunction of the immune system triggered by immunopathological mechanisms. Neutrophils are the most abundant circulating leukocytes, playing a critical role in the pathogenesis of multiple inflammatory conditions. Several studies have demonstrated that neutrophils are key contributors to COVID-19 disease pathogenesis; however, their role in disease progression remains unclear. Here, we demonstrate immune dysregulation in COVID-19 patients characterized by a significant expansion of neutrophil numbers and reduced frequency of T-cell populations. We identify an immature …
Knocking At The Door: The Life And Legacy Of Dr. James Montgomery, Haley Eloise Wells
Knocking At The Door: The Life And Legacy Of Dr. James Montgomery, Haley Eloise Wells
All ETDs from UAB
The life and work of Black Birmingham cardiologist, Dr. James T. Montgomery, demonstrates the importance of viewing the history of health activism and Birmingham civil rights history as two interconnected histories that influenced each other. Traditionally, secondary scholarship on the Birmingham civil rights movement and scholarship on the history of healthcare have been treated as two separate areas of study. Scholars such as Glenn Eskew and Diane McWhorter have written extensively on the civil rights movement in Birmingham, but their scholarship excludes any comprehensive discussion of the fight for racial justice within Birmingham’s medical field. Conversely, scholars such as Thomas …
Access To And Service Utilization Of Alabama Medicaid's Section 1115 Demonstration Waiver Program, Sarah Lee Bowler
Access To And Service Utilization Of Alabama Medicaid's Section 1115 Demonstration Waiver Program, Sarah Lee Bowler
All ETDs from UAB
Background: Much research has been done investigating health disparities in the field of publicly-funding family planning. However, no longitudinal analysis has been conducted to examine the impact of Alabama Medicaid’s Section 1115 demonstration waiver on access to care, experience of barriers reported by enrollees, and repeat utilization of services. Methods: Medicaid enrollment and visit claims data were used to answer the questions related to access and service utilization. Annual Plan First survey data were used to investigate the experience of barriers to care among enrollees. For all three research questions, descriptive statistics were calculated, and linear probability models were used …
Environmental Influences On The Physiology Of Cnidarians And Their Symbionts, Shelby Gantt
Environmental Influences On The Physiology Of Cnidarians And Their Symbionts, Shelby Gantt
All ETDs from UAB
Corals and other cnidarians maintain complex symbioses that include photosynthetic endosymbiotic dinoflagellates (Symbiodiniaceae), protozoans, fungi, bacteria, archaea, and other metazoans, collectively known as the holobiont. The stability of these associations is crucial for holobiont resilience and adaptation to environmental conditions and are the results of long-term ecological and evolutionary processes. Environmental factors such as light availability, seasonal environmental fluctuations, and warmer, more acidic conditions can disrupt these symbiotic associations and alter holobiont functioning. To understand the influence of different environments on cnidarian host and symbiont physiology, two framework coral species (Acropora palmata and Orbicella faveolata) from nursery-raised and wild populations …
Exploring The Associations Between Cognitive Training, Social Determinants Of Health, And Driving Behaviors: A Longitudinal Analysis Of The Active Study, Katie Wheeler
All ETDs from UAB
As the average lifespan increases, older adults are remaining independent into older ages than before. The ability to drive a vehicle is an essential part of daily living that helps older adults maintain independence. Cognitive training, specifically speed of processing training (SOPT), is an intervention that has consistently shown to benefit older adult’s driving abilities and driving behaviors. This dissertation examined the longitudinal association between cognitive training and primary driving location on crash risk across 20 years (Paper 1), investigated the effects of cognitive training and dosage on driving mobility across 10 years (Paper 2), and explored social determinants of …
The Prescription Drug Monitoring Program And Its Effect On Drug Overdose Mortalities, Charles Lee
The Prescription Drug Monitoring Program And Its Effect On Drug Overdose Mortalities, Charles Lee
All ETDs from UAB
The opioid epidemic is a growing concern, and the health and economic impacts on rural and urban counties are increasing. Between 1999 and 2019, approximately 841,000 people died from drug overdoses involving heroin, synthetic opioids, and prescribed opioids with 71,000 dying in 2019. This study examined the relationship between drug overdose mortalities and three independent variables, (a) Medicaid expansion, (b) Years PDMP active, and (c) Academic detailing engagement. Results of this study will contribute to the literature by determining if the Medicaid expansion, years prescription drug monitoring programs active, and academic detailing engagement decrease drug overdose mortalities. This study includes …
Unmasking Molecular Mechanisms Of Multiple Maladies Through Multiomic Methodologies, Luke Potter
Unmasking Molecular Mechanisms Of Multiple Maladies Through Multiomic Methodologies, Luke Potter
All ETDs from UAB
Much modern biomedical research is invested in determining causative molecular mechanisms and identifying potential therapeutics within human disease or injury. Traditional experiments such as over-expressing or “knocking out” the level of a gene’s abundance can determine the specific contribution of a single gene to a pathology and are a vital component of scientific research. However, taking a big picture approach through the application of ‘omics technologies can lead to a broader overall understanding of a pathology and can potentially generate numerous specific hypotheses to be tested using the more traditional molecular approaches. In this dissertation, transcriptomic and epigenomic technologies, measuring …
Using Hope To Cope: Chronic Stress, Religious Coping, And Masked Hypertension In African American Adults: The Jackson Heart Study, Miriam Miles
All ETDs from UAB
USING HOPE TO COPE: CHRONIC STRESS, RELIGIOUS COPING, AND MASKED HYPERTENSION IN AFRICAN AMERICAN ADULTS: THE JACKSON HEART STUDY ABSTRACT Chronic stress experienced at home or work has been associated with acute increases in blood pressure (BP) measured in the doctor’s office. Few data are available on the association of chronic stress with BP measured outside of the office setting. Religious coping, applying religious beliefs to adapt to stressful situations, and functional and structural social support may protect against MHT by promoting active coping behaviors and increasing emotional well-being. High levels of religious involvement and high social support have been …
Effect Bioactive Material Have On Tooth Demineralization, Taillk Gomes
Effect Bioactive Material Have On Tooth Demineralization, Taillk Gomes
All ETDs from UAB
The objective of this in vitro study is to compare the inhibition of demineralization of root dentin caused by the presence of different restorative materials using Vickers Hardness (HV) test (microhardness) test and polarized light microscopy (PLM).
Using The Social Ecological Model To Assess The Correlates Of Unprotected Sex Among African American Emerging Adults, Shirlacia S. Gray
Using The Social Ecological Model To Assess The Correlates Of Unprotected Sex Among African American Emerging Adults, Shirlacia S. Gray
All ETDs from UAB
USING THE SOCIAL ECOLOGICAL MODEL TO ASSESS THE CORRELATES OF UNPROTECTED SEX AMONG AFRICAN AMERICAN EMERGING ADULTS SHIRLACIA S. GRAY DEVELOPMENTAL PSYCHOLOGY ABSTRACT Background: The Centers for Disease Control and Prevention (CDC) reported that HIV diagnoses for Black/African American men and women are 8x and 15x higher than white individuals, respectively. While the social determinants of health largely influence HIV transmission rates, reducing risky behaviors can lower the risk for HIV. This current study used the Social Ecological Model to investigate correlates of unprotected sex. Methods: Participants were recruited through respondent-driven sampling. Participant's demographics (age, gender, years of education, financial …
Predicting Maximum Concentric And Eccentric Squat Strength From Maximum Isometric Squat Strength, Michael A. Dunn
Predicting Maximum Concentric And Eccentric Squat Strength From Maximum Isometric Squat Strength, Michael A. Dunn
All ETDs from UAB
Resistive squat exercise is a well-established technique to enhance the strength of muscles and bone of the back in humans. Such type of exercise could prove highly beneficial for individuals with pathological condition of the back such as osteoporosis. Notably, the rehabilitation programs aimed at strengthening the muscles and bone of the back require the knowledge of the patient’s one repetition maximum (1RM). Finding the 1RM squat value could lead to injury due to the higher weights involved. In addition, testing for 1RM could be not feasible in older populations or young population with chronic back conditions The isometric squat …
The Impact Of O-Glcnac Signaling On Dna Hydroxymethylation In Temporal Lobe Epilepsy, Rudhab Bahabry
The Impact Of O-Glcnac Signaling On Dna Hydroxymethylation In Temporal Lobe Epilepsy, Rudhab Bahabry
All ETDs from UAB
Temporal Lobe Epilepsy (TLE) is the most prevalent form of focal epilepsy and the most treatment-resistant type. This condition is characterized by recurrent, unprovoked seizures typically originating in the hippocampus. Epigenetic modifications such as DNAme changes have been implicated in brain functions such as synaptic plasticity, learning and, memory, and cognition. The oxidation of DNA 5-methylcytosine (5-mC) and its oxidized form, 5-hydroxymethylcytosine (5-hmC) catalyzed by Ten-Eleven Translocation (TET) family of dioxygenases and linked to epilepsy's hyperexcitable state. Post‐translational modifications (PTMs) of proteins, such as O-GlcNAcylation, facilitate cells' immediate responses to intracellular or extracellular environmental stimuli by modifying the functions of …
A Thematic Analysis Of Health Literacy And Education Disparities Regarding Medical Needs For Transgender Individuals, Rachel Mcmullen
A Thematic Analysis Of Health Literacy And Education Disparities Regarding Medical Needs For Transgender Individuals, Rachel Mcmullen
All ETDs from UAB
Transgender individuals experience many challenges within the healthcare system including discrimination, socioeconomic struggles, financial strains, a lack of educated healthcare providers, and a health system framework that makes it even more challenging for them to receive their medical needs (Korpaisarn and Safer). One contributing factor to this lack of education is that on average medical schools in the United States only spend approximately five hours total on the health needs related to lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals (Miller et al.). Another contributing factor is the stigma around LGBTQ individuals within the medical community. The stigma is concerning …
3d Microtissue Model Of The Aged Ovarian Tumor Microenvironment, Peyton Clark
3d Microtissue Model Of The Aged Ovarian Tumor Microenvironment, Peyton Clark
All ETDs from UAB
Ovarian cancer is the 5th leading cause of cancer deaths for women, primarily due to treatment resistant and/or recurrent disease. Most cases of ovarian cancer are not diagnosed until distant metastases have formed, which drastically reduces overall survival. The median age at diagnosis is 63 and most cases occur in patients who are peri- and post-menopausal. There is a critical gap between the clinical presentation of ovarian cancer and the preclinical models used to study the disease. Most preclinical in vivo investigations use mice who are between 6 and 12 weeks old, which corresponds to roughly a 20-year-old human. Therefore, …
Temporal And Epigenetic Mechanisms Underlying Dietary Phytochemicals In Breast Cancer Prevention, Andrew Brane
Temporal And Epigenetic Mechanisms Underlying Dietary Phytochemicals In Breast Cancer Prevention, Andrew Brane
All ETDs from UAB
Breast cancer (BC) is a widespread malignancy that, despite advancements in treatments and improvements in survival, had an estimated 297,790 new cases and 43,170 mortalities in 2023. With around 1 in every 8 women in the US expected to be diagnosed with BC at some point in their lives, the economic, societal, and healthcare burdens associated with this disease cannot be understated. Because of this, treatments and preventions that are affordable, efficacious, and easily administered are in high demand. Preventive therapies have shown great promise in reducing disease burden with relatively few serious side effects. BC prevention through the consumption …
Identification Of The Synthetic Cannabinoids Bzo-Poxizid And Mda-19 Using Gas Chromatography- Mass Spectrometry, Samantha Way
Identification Of The Synthetic Cannabinoids Bzo-Poxizid And Mda-19 Using Gas Chromatography- Mass Spectrometry, Samantha Way
All ETDs from UAB
Synthetic cannabinoids are synthetic compounds created to mimic the effects of naturally derived cannabis. They are up to 100 times more potent than natural cannabis, and due to their cannabinoid-like activity, they are considered schedule one drugs in Alabama. They are also the most common new psychoactive substance in the state of Alabama. The possible threat to public health and their schedule one status makes it necessary to develop a method for the detection of these substances. BZO-POXIZID and MDA-19 are two synthetic cannabinoids of recent interest. This study was conducted to validate a method for the detection of these …
The Association Between Cardiovascular Disease Risk And Fractures In Postmenopausal Women, Rafeka Hossain
The Association Between Cardiovascular Disease Risk And Fractures In Postmenopausal Women, Rafeka Hossain
All ETDs from UAB
Background: Fragility fractures pose a significant healthcare and economic burden in the United States. While age and bone mineral density (BMD) are the primary established risk factors for fragility fractures, the relationship between cardiovascular disease (CVD) and fractures remains underexplored. The primary objective of this analysis was to estimate the association of CVD risk with fractures in postmenopausal women. Methods: Utilizing 30 years of data from the WHI, Atherosclerotic Cardiovascular Disease (ASCVD) risk scores were computed using baseline age, race, systolic blood pressure, total cholesterol, high-density lipoprotein, diabetes, anti-hypertension medications, and smoking. Fracture outcomes encompassed any clinical fracture, major osteoporotic …
Comparative Enzymatic Analysis Of Different Isoforms Of Group A Streptococcal Bacteriophage H4489a Hyaluronidase, Urvi Prakash Rawal
Comparative Enzymatic Analysis Of Different Isoforms Of Group A Streptococcal Bacteriophage H4489a Hyaluronidase, Urvi Prakash Rawal
All ETDs from UAB
The Hyaluronate Lyase derived from Group A streptococcal bacteriophage H4489A gene (HylP) is known for cleaving the glycosidic bonds of high molecular weight hyaluronic acid (HMWHA), a substance often overexpressed in certain types of cancer cells. This enzymatic action produces HA oligosaccharides. Previous research, conducted by our team, has demonstrated that these oligosaccharides play a significant role in reducing the invasion, migration, and proliferation of breast cancer cells. This effect occurs through the disruption of Erk1/2 activation and RhoA expression. This bacteriophage hyaluronate lyase (HylP), a 40kDa protein, possesses a unique collagen-like sequence, consisting of 30 amino acids in a …