Digital Commons Network^™

Diastereoselective Synthesis Of The Hiv Protease Inhibitor Darunavir And Related Derivatives Via A Titanium Tetrachloride-Mediated Asymmetric Glycolate Aldol Addition Reaction, Jordan M. Witte, Emmanuel Ayim, Christopher J. Sams, Jasmine B. Service, Caitlyn C. Kant, Lillian Bambalas, Daniel Wright, Austin Carter, Kelly Moran, Isabella G. Rohrig, Gregory M. Ferrence, Shawn R. Hitchcock

Faculty Publications – Chemistry

Darunavir is a potent HIV protease inhibitor that has been established as an effective tool in the fight against the progression of HIV/AIDS in the global community. The successful application of this drug has spurred the development of derivatives wherein strategic regions (e.g., P1, P1’, P2, and P2’) of the darunavir framework have been structurally modified. An alternate route for the synthesis of darunavir and three related P1 and P1’ derivatives has been developed. This synthetic pathway involves the use of a Crimmins titanium tetrachloride-mediated oxazolidine-2-thione-guided asymmetric glycolate aldol addition reaction. The resultant aldol adduct introduces the P1 fragment of …

Feasibility Of Influencing Clinician Perceived Knowledge And Competence Of Human Trafficking Via A Continuing Education Workshop, Rachel Wakefield

College of Graduate Studies: Theses & Dissertations

Previous research has examined the complex mental and social health deficits of those who were trafficked that clinicians have to treat therapeutically (Litam, 2017; Pascual-Leone et al., 2017). Other research has explored how continuing education workshops often change the knowledge, competence, and attitudes of attendees to use more effective and evidenced techniques and skills (Neimeyer et al., 2009; Raghavan et al., 2008). However, there is a lack of understanding about how a complex topic, specifically treatment considerations of those who were trafficked, changes the knowledge and competence of continuing education workshop attendees. The purpose of the current study is to …

Life After Discharge: Predicting Longitudinal Trajectories Of Community Integration And Global Functioning In Black Individual With Traumatic Brain Injury, Chimdindu Ohayagha

Theses and Dissertations

The onset of traumatic brain injury (TBI) begins a chronic health pathway that contributes to various impairments and comorbidities across the lifespan. Common consequences of TBI include mental health issues, cognitive impairments, and reduced functional independence, all of which impact how an individual integrates into their community. Community integration is a primary goal for rehabilitation after TBI. Studies show that racially/ethnically minoritized individuals have a higher incidence of TBI, higher rates of mortality, and report poorer functional and community integration outcomes. Limited studies have explored longitudinal outcomes of community integration in a Black-only sample of individuals with TBI. Additionally, no …

Postoperative Antibiotics For Diabetic Patients With Complicated Appendicitis, Bill D. Pope Iii, Alejandro J. Candil

MEDI 9331 Scholarly Activities Clinical Years

This retrospective study, conducted at Valley Baptist Medical Center from March 14, 2020, to December 3, 2023, explores the impact of postoperative antibiotics on diabetic patients with complicated appendicitis. Out of 494 appendectomy patients, 17 diabetic patients with complicated appendicitis were analyzed. Of these, 15 received postoperative antibiotics, with 2 developing infections (13%), while the 2 did not receive postoperative antibiotics and remained infection-free. The study acknowledges limitations in sample size and the subjective nature of defining complicated appendicitis. These findings contribute to ongoing discussions on postoperative antibiotic practices, particularly in diabetic patients with complicated appendicitis.

Medical Students Attending Schools Along The Us-Mexico Border: Experiences From Bilingual And Monolingual Students, Roger Banda Jr, Aaron Silva, Ney Alliey Rodriguez

MEDI 9331 Scholarly Activities Clinical Years

We present a study that aims to capture experiences of bilingual and monolingual medical students exposed to patient populations with limited English proficiency along the US-Mexico border. The study surveyed US-Medical students at The University of Texas Rio Grande Valley in the clerkship years of medical education. A total of 121 medical students were surveyed consisting of both bilingual and monolingual students of which 32 responded (26%). Of the students surveyed, 0% reported being certified as medical language interpreters. 24% reported feeling somewhat uncomfortable and 10% extremely uncomfortable while interpreting, 48% reported sometimes making errors in translation, and 33% reported …

The Oral-Microbiome-Brain Axis: A Thorough Review On The Relationship Between Periodontitis And Alzheimer’S Disease And A Proposed Innovative Application Of Biomagnetism As A Means Of Alternative Therapy., Taha Al Hassan, Noah Al-Hassan, Maria Quiñones-Peña, Juan Lopez-Alvarenga, Seratna Guadarrama-Beltran

MEDI 9331 Scholarly Activities Clinical Years

The relationship between periodontitis and Alzheimer's disease (AD) has garnered significant attention due to the potential influence of chronic oral inflammation on neurodegenerative processes. Our hypothesis is supported by the oral-microbiome-brain axis and highlights the possibility that chronic periodontitis contributes to cognitive decline by promoting systemic inflammation and neuroinflammation, mediated by specific pathogenic microorganisms within the oral microbiome. Our findings reveal a strong association between elevated levels of Porphyromonas gingivalis and Treponema denticola, red complex bacteria, and markers of systemic inflammation, such as C-reactive protein (CRP) and pro-inflammatory cytokines. Additionally studies have demonstrated that beta amyloid plaque in rat …

Colorful Lizards And The Conflict Of Collection, Colin M. Goodman, Natalie M. Claunch, Zachary T. Steele, Diane J. E. Sturgeon, Christina M. Romagosa

Human–Wildlife Interactions

Invasive species threaten biodiversity, and their management is economically burdensome. Research on the indirect effects of introduced species are often focused on indirect ecological effects, with little focus on the more difficult to capture but critically important societal impacts. Often understated are the social costs of invasive species such as conflicts between invasive species managers and public stakeholders. Chameleons (Chamaeleonidae) are popular in the pet trade and have been introduced throughout Florida, USA, and their presence often attracts private collectors. After locating a population of panther chameleons (Furcifer pardalis) within a suburban neighborhood in central Florida, we administered …

Grazing Management For Livestock, Free-Roaming Horses And Burros, And Resilience, Sherman R. Swanson

Human–Wildlife Interactions

Grazing management avoids overgrazing by allocating forage for livestock on the basis of animal unit months and managing wild and free-roaming horses (Equus caballus) and burros (E. asinus) to achieve and maintain an appropriate management level (AML) for each herd. Riparian green forage and water attracts cattle (Bos taurus) and equids when upland forage is brown. Key species that focus management for resilience to weather variation, fire, and floods are preferred forage plants for cattle and horses. They include riparian stabilizers such as densely rooted sedges and deep-rooted perennial grasses in sagebrush (Artemisia …

Special Topic: Pest And Beneficial Bird Management, Breanna Martinico, Shannon Skalos

Human–Wildlife Interactions

This is the call for papers for the special issue on Pest and Beneficial Bird Management.

"Shut Down And Closed Off": A Routine Activity Approach To Investigating The Relationship Between Covid-19 School Closures And Child Sexual Abuse Report Characteristics In Georgia, Spencer E. Riner

College of Graduate Studies: Theses & Dissertations

The COVID-19 pandemic of 2020 created a public health crisis that led to an unprecedented number of school closures. A major concern raised by child advocates, law enforcement, and social service providers was the possible increase in undetected child abuse and maltreatment. Undergirding this concern was the belief that this mitigation effort might place child abuse victims and offenders within proximity for extended periods of time. While this was a significant concern, it has rarely been analyzed empirically. To address this gap in the literature, this thesis investigates how school closures impacted the characteristics of child sexual abuse (CSA) reports …

Multi-Year Effectiveness Of Pzp-22 In Free-Roaming Suburban White-Tailed Deer, Allen T. Rutberg, Kali M. Pereira, Kayla A. Grams, John W. Turner Jr.

Human–Wildlife Interactions

To address the challenge that is posed to the use of fertility control to mitigate human–deer (Cervidae) conflicts by the need to regularly re-inoculate free-roaming animals, we captured, ear-tagged, and hand-injected 68 individual adult female white-tailed deer (Odocoileus virginianus) with the PZP-22 immunocontraceptive vaccine from February through April, 2014 to 2017, in the Village of Hastings-on-Hudson, New York, USA. Approximately 2.5 years after initial treatments, we booster-darted 29 of the previously treated females with either PZP-22 or native PZP (ZonaStat-D). We observed fawn production between 2014 and 2021. The combination of initial PZP-22 hand-treatments followed by single dart-delivered PZP …

Spatial Predictors Of Human–Black Bear Interactions In Nova Scotia, Canada, Jason I. Airst, Tricia B. Fleming

Human–Wildlife Interactions

The increased global frequency of human–wildlife conflict with large, wild carnivores and omnivores negatively impacts human, wildlife, and ecosystem health. The goal of this study was to determine what landscape characteristics best predicted where human–black bear (Ursus americanus) interactions occurred in Nova Scotia, Canada, to support management efforts. We compared the location of 3,278 human–bear conflict reports and 867 non-conflict reports collected between 2017 and 2021 to 12,000 randomly generated locations. Data were analyzed using logistic additive mixed models. We found that interactions (conflict and non-conflict reports) occurred near roads and farther from forests and surface water features. …

The Effects Of Cultural Responsiveness And Therapy Duration On Black Americans’ Therapy Preference, Katilyn M. Ashley Treem

College of Graduate Studies: Theses & Dissertations

Marginalized groups are less likely to seek out mental health services than non-marginalized groups. There are various reasons why marginalized groups, such as Black Americans, are less likely to seek out mental health services, one of which is the cultural barriers between a clinician and client. Research suggests that Black Americans feel that clinicians struggle to overcome these cultural barriers. Therefore, it is important for clinicians to actively receive training on how to serve clients with diverse backgrounds. Cultural responsiveness, an extension from cultural competence, is the active application of the knowledge and skills obtained in training. Examining people’s therapy …

Efficacy Of A Laser As A Starling Deterrent And Its Effect On Lactating Dairy Cow Behavior, Callan A. Lichtenwalter, Marcos Marcondes, Kyle R. Taylor, Craig Mcconnel, Amber Adams Progar

Human–Wildlife Interactions

European starlings (Sturnus vulgaris) cause damage (including structural damage) on dairies, eat cattle feed, and can potentially spread disease through their fecal matter. Deterring starlings from dairies without affecting cow (Bos taurus) welfare is vital, and lasers have been effective starling deterrence tools in urban roosts and in some crops. To evaluate if the use of lasers on dairies would affect starling use of freestall barns as night roosts, or lactating cow behavior, 1 laser was installed in each of the 2 freestall barns at the Knott Dairy Center at Washington State University, Pullman, Washington, USA. …

The Relation Between Disordered Eating And Perceived Stress, Tori E. Byars

College of Graduate Studies: Theses & Dissertations

Disordered eating behavior encompasses a spectrum of maladaptive eating patterns, including emotional eating, binging, restricting, and other similar behaviors. Perceived stress is the extent that an individual perceives their demands exceed their ability to cope. Existing research has demonstrated a positive relation between high ratings of perceived stress and disordered eating behaviors (King et al., 2009; Skead et al., 2018). The current study aimed to expand this research by examining the relation between disordered eating and stress in students, workers, and those who partake in both commitments. Utilizing a single survey, participants completed assessments including the Perceived Stress Scale, the …

Examining The Relationship Between Puberty And Trauma Symptomatology, Justina M. Harsche

College of Graduate Studies: Theses & Dissertations

This study sought to examine the relation between puberty and trauma symptomatology in young adults. More specifically, does it matter what developmental period one is in when trauma occurs? Additionally, geographical region was examined as it relates to receiving and reporting mental health services and later trauma symptoms. Using data from 362 students at Georgia Southern University, multiple analyses were conducted. A Moderation Analysis where adverse events served as the predictor, trauma symptomatology as the outcome variable, and the developmental period in which the trauma occurred as the moderator was conducted. The interactions for this hypothesis were not significant. However, …

Self-Authorship Among First-Generation Learners: A Qualitative Study, Issac C. Taylor

College of Graduate Studies: Theses & Dissertations

In the realm of higher education, an increasingly important concern is the intellectual capacity of first-generation learners. To improve their cognitive, intrapersonal, and interpersonal development in contemporary society, it is essential for institutions to gain a comprehensive understanding of these students' unique challenges. The existing body of literature on first-generation students has predominantly centered on the personal challenges and institutional barriers that impede their pursuit of higher education. However, promoting self-authorship among this student population presents a unique opportunity for faculty, staff, and administrators to facilitate and reinforce the developmental needs of students who are the first in their families …

Chronic Training Load And Dorsiflexion Range Of Motion Throughout A Season In Professional American Soccer, Tristan L. Young

College of Graduate Studies: Theses & Dissertations

Soccer has an incredibly complex movement profile. Players experience various types of strains on their body from the requirement to land in awkward positions while maintaining the ability to quickly accelerate and decelerate. Dorsiflexion range of motion (DFROM) is of concern due to the movement profile and ball control that requires constant eccentric and concentric actions at the talocrural joint. With an American soccer season spanning across nine months these demands can contribute to overuse, which has been linked to restricted range of motion. Restricted DFROM and asymmetries have been identified as injury predictors, but their relationship to performance has …

Snake Translocation Policies And Practices Within The United States, Robin E. Bedard, Megan Rottenborn, Emily Taylor

Human–Wildlife Interactions

Human–wildlife conflict with nuisance snakes (Serpentes) is rapidly increasing with human population growth and development rates. Translocation of nuisance snakes has become a widespread practice, aided by social media pages connecting people to volunteer and for-profit snake translocators. However, translocators often struggle to find information and resources from wildlife agencies about the policies required, and some may unintentionally use translocation procedures that disregard the health and survival of the snakes. The goals of this study were to (1) obtain data on policies, permitting, and training required for translocating nuisance snakes in each U.S. state that has snakes and (2) compare …

Impact Of Road Infrastructures On The Abundance Of Common Chameleon Populations, Pablo García-Quevedo, Francisco Díaz-Ruiz, Antonio Román Muñoz, Jesús Duarte, Adrián Martín-Taboada, José-María García-Carrasco, Miguel Ángel Farfán

Human–Wildlife Interactions

The common chameleon (Chamaeleo chamaeleon) is a threatened species in Spain. The loss and transformation of their traditional habitats are among the main causes of its decline. Linear infrastructures, such as roads and highways, cause direct habitat loss, roadkill, and fragmentation of populations by acting as an artificial barrier. In this study, we investigated the potential effect of 2 high-speed road infrastructures in southern Spain on local populations of common chameleons. A total of 34 grids of 1x1 km were sampled, differentiating between grids without road presence (n = 17) and grids with road presence (n …

Waterbird-Perceived Damage, Control Measures, And Economic Implications For Rice Production In The Brazilian Cerrado, Demetrio Luis Guadagnin, Alexandre Afonso Meyer, João Augusto Rossi Borges, Fernanda Maia Justo

Human–Wildlife Interactions

Waterbirds have the potential to inflict economic damage to crops. However, is rice (Oryza sativa) production in the Brazilian Cerrado significantly affected by waterbirds? This study aimed to assess the extent of waterbird damage on irrigated rice production in Central Brazil. We conducted surveys of waterbird populations in rice agroecosystem habitats throughout the cultivation cycle and analyzed the expenses associated with waterbird-induced yield losses and the control measures employed by farmers. The 2 most prevalent waterbird species observed were Dendrocygna viduatta and D. autumnalis, comprising 68.6% of all recorded waterbirds. These species were more frequently encountered and …

Spatial Analysis Of Socioeconomic Factors At Found Locations Of Orphaned Mammals In Champaign County, Illinois, Usa, Colleen Elzinga, Stephanie Heniff, William Sander, William Marshall Brown, Csaba Varga, Samantha Sander

Human–Wildlife Interactions

Young mammals make up a significant portion of animals brought into wildlife rehabilitation centers. Unfortunately, some of these presumed orphaned individuals are inappropriately removed from their native habitat. As such, there is a need for educational community outreach centered on the proper identification of orphaned wildlife that benefit from human intervention, while maximizing limited resources of rehabilitation facilities. This study evaluated found locations of common mammalian orphans presenting from Champaign County to the University of Illinois Wildlife Medical Clinic, Illinois, USA, between 2015 and 2020. The found locations of the orphans (99 Virginia opossums [Didelphis virginiana], 80 common …

Exploring Police K-9 Deaths, Their Causes, And Possible Remedies, John Wise

College of Graduate Studies: Theses & Dissertations

Police K-9s face daily dangers due to their work. Data collected by the Officer Down Memorial Page from 2000-2023 on K-9 deaths (N = 405) shows that of K-9s that die in the line of duty, many fall victim to heat stroke. Research was conducted comparing heat stroke to all other causes of death. Through an exploration into the history of mankind’s use of working dogs, the unique capabilities of both dogs and K-9 specific dog breeds and applying Routine Activity Theory and Lifestyle Routine Activity Theory to police K-9s, this study’s objective is to bring awareness to, and …

Monograph Available: Toolkit To Address Free-Ranging Domestic Cats On Agency Lands Managed For Native Wildlife And Ecosystem Health

Human–Wildlife Interactions

This is an announcement about the published monograph titled "Toolkit to Address Free-ranging Domestic Cats on Agency Lands Managed for Native Wildlife and Ecosystem Health." This publication, part of the HWI Monograph Series, is online and open access.

The U.S. Southern Mothers Perspective On Affection, Destiny M. Rose

College of Graduate Studies: Theses & Dissertations

This qualitative research study utilizes Murray Bowen’s Family Systems Theory and Kimberlé Crenshaw’s Intersectionality Theory to examine how ten mothers residing in what is identified as the U.S. Deep South (Georgia, Alabama, and South Carolina) perceive affection shown to their children by adults outside of their nuclear family. Additionally, this study considers the influence social class plays in how parents in the Deep South navigate and negotiate social and cultural norms when it comes to affection displays shown to their children. Data was collected using thematic analysis to describe how parents in parts of the Deep South perceive affection shown …

Training Underrepresented Minority Students For Careers In Public Health Leadership – Public Health Leaders Fellowship Program, Jigsa Tola

College of Graduate Studies: Theses & Dissertations

Background: Shortage and lack of diversity in the United States public health workforce is well documented and remains a challenge to meaningfully improving the health of the population. Although the diversity of the public health workforce has implications for access, care quality, and career opportunities in low-income communities, there is no strong mechanism by which minorities are trained to replenish the workforce. Morehouse College’s Public Health Leaders Fellowship Program (MC-PHLFP) is a cooperative program with the Centers for Disease Control and Prevention (CDC) to train undergraduate students for careers in public health leadership.

Purpose: The purpose of this research is …

The Effect Of First-Person Testimonial Versus Didactic Video Interventions On Attitudes And Behavioral Intentions Toward Buprenorphine, Tristan S. Fletcher

College of Graduate Studies: Theses & Dissertations

Emerging adults exhibit disproportionately elevated levels of substance use disorders (Substance Abuse and Mental Health Services Administration [SAMHSA], 2021), opioid misuse (SAMHSA, 2021), and opioid use (Hu et al., 2017; Jones et al., 2015) compared to other age cohorts. If left untreated, opioid misuse and opioid use disorder can lead to various negative consequences, including premature death (Strang et al., 2020). Prior research indicates emerging adults have higher opioid-related mortality rates compared to other age groups in the United States (Gomes et al., 2018). Buprenorphine, an opioid partial agonist medication, is an effective intervention for opioid use disorder (Mattick et …

Social And Structural Determinants Of Health As Predictors Of Covid-19 Vaccine Hesitancy Among Older Adults In The United States, Kingsley Kalu

College of Graduate Studies: Theses & Dissertations

Background: Although vaccination is one of the greatest accomplishments in public health, some people, especially older adults, are reluctant to take vaccines. This study examined the association between the social and structural determinants of health and COVID-19 vaccine hesitancy among older adults in the United States.

Methods: Secondary data from the Health and Retirement Study (HRS) was used. The HRS participants were 65 years and older, and the sample size was 2311. Multinomial multivariable logistic regression models were conducted for this study.

Results: The study shows that social determinants of health (marital status, educational level) and structural determinants of health …

Cybercrime Victimization: Online Routine Behaviors, Guardianship, And Identity Theft Victimization In A Nationally Reflective Sample, Ifeoluwa Stella Elegbe

College of Graduate Studies: Theses & Dissertations

In this digital era, cybercrime victimization has emerged as a significant issue, with identity theft being one of the most prevalent forms. This study examines the relationship between online routine behaviors, guardianship, demographics, and identity theft victimization in a nationally representative sample of U.S. adults utilizing routine activities theory (RAT) as a conceptual

framework. The research applies statistical methods such as descriptive statistics, correlation analysis, and logistic regression models to examine theoretically oriented hypotheses. The

hypotheses suggest connections between different online habitual behaviors, steps taken to

protect oneself, demographic characteristics, and the extent to which one has been a victim …

What Does It Mean To Be The Goat: A Narrative Study On Retired White Male Elite Individual Sport Athletes?, Tyler Behrmann

College of Graduate Studies: Theses & Dissertations

The greatest of all time (GOAT) is a topic commonly discussed in sports today (Lundberg & Rosenberg, 2020). Despite this increased use of the term, there is a lack of research on the topic of the GOAT which could serve to benefit individuals in performance domains. The purpose of this qualitative exploratory study was to investigate characteristics that describe a GOAT and the impact these characteristics of the GOAT have on individuals. Two participants were included in this study. The participants were white male, retired, and individual sport athletes who competed in multiple World Championships. Participants were interviewed using semi-structured …