Digital Commons Network^™

A Mini Chalk Talk Workshop For Fourth-Year Medical Students: Facilitating The Transition From Student To Resident Educator, Trevor Jamison, Zaven Sargsyan, Uma Ayyala, Stephanie Sherman, Holland Kaplan

Faculty, Staff and Students Publications

INTRODUCTION: There is increasing recognition that incoming interns benefit from formal training in teaching skills during UME. Many medical schools have capstone courses well suited for teacher-training content. Mini chalk talks (MCTs) are a common clinical teaching modality requiring a variety of teaching skills. We developed a session for our institution's capstone course in which students prepared and delivered MCTs.

METHODS: The voluntary flipped classroom session was offered virtually in 2021 and in person in 2022. Before the session, students reviewed materials on creating effective MCTs and developed and practiced their own MCT. During the 90-minute session, students presented their …

Utilizing Low-Tech Portable Caterpillar Tunnels To Increase Productivity Of Warm-Season Vegetables And Small Fruits, Bijaya Ghimire

Plant Sciences

High tunnels and greenhouses effectively extend the growing season and protect crops from adverse environmental conditions. However, production in the less expensive and portable caterpillar tunnel has not been reported. The research aimed to evaluate the phenology, yield and quality of eight paste tomato, eight bell pepper, and two cold-hardy wine grapes grown in the caterpillar tunnel compared to the open field. In 2022, tomato and bell pepper cultivars were severely affected by tomato spotted wilt virus. Caterpillar tunnels extended the growing season and accelerated the key phenological stages of all three species. The tunnel increased the yield and quality …

Targeting Histone Deacetylase In Cardiac Diseases, Jiao Lu, Sichong Qian, Zheng Sun

Faculty, Staff and Students Publications

Histone deacetylases (HDAC) catalyze the removal of acetylation modifications on histones and non-histone proteins, which regulates gene expression and other cellular processes. HDAC inhibitors (HDACi), approved anti-cancer agents, emerge as a potential new therapy for heart diseases. Cardioprotective effects of HDACi are observed in many preclinical animal models of heart diseases. Genetic mouse models have been developed to understand the role of each HDAC in cardiac functions. Some of the findings are controversial. Here, we provide an overview of how HDACi and HDAC impact cardiac functions under physiological or pathological conditions. We focus on in vivo studies of zinc-dependent classical …

High Prevalence Of A-Β+ Ketosis-Prone Diabetes In Children With Type 2 Diabetes And Diabetic Ketoacidosis At Diagnosis: Evidence From The Rare And Atypical Diabetes Network (Radiant), Elizabeth Kubota-Mishra, Xiaofan Huang, Charles G Minard, Marcela Astudillo, Ahmad Refaey, Graciela Montes, Stephanie Sisley, Nalini Ram, William E Winter, Rochelle N Naylor, Ashok Balasubramanyam, Maria J Redondo, Mustafa Tosur, Radiant Study Group

Faculty, Staff and Students Publications

BACKGROUND:A−β+ ketosis-prone diabetes (KPD) in adults is characterized by presentation with diabetic ketoacidosis (DKA), negative islet autoantibodies, and preserved β-cell function in persons with a phenotype of obesity-associated type 2 diabetes (T2D). The prevalence of KPD has not been evaluated in children. We investigated children with DKA at “T2D” onset and determined the prevalence and characteristics of pediatric A−β+ KPD within this cohort.

METHODS: We reviewed the records of 716 children with T2D at a large academic hospital and compared clinical characteristics of those with and without DKA at onset. In the …

Effects Of Synonymous And Nonsynonymous Cyp51 Mutations On Dmi Resistance In Cercospora Beticola, Isaac Courneya

Plant Pathology

Cercospora beticola is the most devastating foliar pathogen of sugar beet. This pathogen is primarily managed by the application of fungicides, including demethylation inhibitors (DMIs). Given the broad use of DMIs in managing Cercospora leaf spot, resistance has developed. Recently, five haplotypes of CbCyp51 have been correlated with DMI resistance. To improve our understanding of these haplotypes, this study has evaluated CbCyp51 expression across haplotypes with and without DMI exposure using RT-qPCR. Significant differences were found between haplotypes in control and difenoconazole groups, but the broader implications were unclear. This study also produced mutant C. beticola strains with replaced CbCyp51 …

Genetic Variation In Black Gram And Guar For Phenology, Physiology, Growth, And Yield Under Irrigated And Rainfed Conditions Of Northern Great Plains, Saurabha Koirala

Plant Sciences

Field trials were conducted in 2022 and 2023 to evaluate the feasibility of growing black gram (Vigna mungo) and guar (Cyamopsis tetragonoloba) and to identify superior accessions for semiarid conditions of Northern Great Plains, U.S. Significant genetic variability was observed among 21 black gram and 18 guar accessions under rainfed and irrigated conditions. Black gram accession PI425187 yielded the highest grain per plant (8.6 g) under rainfed conditions, while PI377397 and PI377406 performed best under irrigated (6.5 g). Number of pod per plant and seeds per pod were highly correlated with yield per plant. The highest guar yield per plant …

Comparison Of Complication Types In Patients Receiving Vesicant Intravenous Antimicrobials Or Vasopressors Via Midlines And Peripherally Inserted Central Catheters, Bryan Grigg, Nishant Varghese, Christi Knapp, Sabra L Shay, Geraldine Jones, James P Herlihy, Prasad Manian, Bradley Lembcke, Mayar Al Mohajer

Faculty, Staff and Students Publications

We assessed adverse events in hospitalized patients receiving selected vesicant antibiotics or vasopressors administered through midline catheters or peripherally inserted central catheters (PICC). The rates of catheter-related bloodstream infections, thrombosis, and overall events were similar across the two groups, while occlusion was higher in the PICC group.

Select Gut Microbiota Impede Rotavirus Vaccine Efficacy, Vu L Ngo, Yanling Wang, Yadong Wang, Zhenda Shi, Robert Britton, Jun Zou, Sasirekha Ramani, Baoming Jiang, Andrew T Gewirtz

Faculty, Staff and Students Publications

BACKGROUND & AIMS: The protection provided by rotavirus (RV) vaccines is highly heterogeneous among individuals. We hypothesized that microbiota composition might influence RV vaccine efficacy.

METHODS: First, we examined the potential of segmented filamentous bacteria (SFB) colonization to influence RV vaccine efficacy in mice. Next, we probed the influence of human microbiomes on RV vaccination via administering mice fecal microbial transplants (FMTs) from children with robust or minimal RV vaccine responsiveness. Post-FMT, mice were subjected to RV vaccination followed by RV challenge.

RESULTS: SFB colonization induced a phenotype that was reminiscent of RV vaccine failure (ie, failure to generate RV …

Community Detection In Censored Hypergraph, Zhao Bin

Statistics

Network, or graph, represent relationships between entities in various applications, such as social networks, biological systems, and communication networks. A common feature in network data is the presence of community structures, where groups of nodes exhibit higher connectivity within themselves than with other groups. Identifying these community structures, a task known as community detection, is essential for gaining valuable insights in diverse applications, including uncovering hidden relationships in social networks, detecting functional modules in biological systems, and identifying vulnerabilities in communication networks. However, real-world network data may have missing values, significantly impacting the network’s structural properties. Existing community detection methods …

Pik-Iii Exerts Anti-Fibrotic Effects In Activated Fibroblasts By Regulating P38 Activation, Santiago Sanchez, Aaron K Mcdowell-Sanchez, Sharaz B Al-Meerani, Juan D Cala-Garcia, Alan R Waich Cohen, Scott A Ochsner, Neil J Mckenna, Lindsay J Celada, Minghua Wu, Shervin Assassi, Ivan O Rosas, Konstantin Tsoyi

Faculty, Staff and Students Publications

Systemic sclerosis (SSc), also known as scleroderma, is an autoimmune-driven connective tissue disorder that results in fibrosis of the skin and internal organs such as the lung. Fibroblasts are known as the main effector cells involved in the progression of SSc through the induction of extracellular matrix (ECM) proteins and myofibroblast differentiation. Here, we demonstrate that 4'-(cyclopropylmethyl)-N2-4-pyridinyl-[4,5'-bipyrimidine]-2,2'-diamine (PIK-III), known as class III phosphatidylinositol 3-kinase (PIK3C3/VPS34) inhibitor, exerts potent antifibrotic effects in human dermal fibroblasts (HDFs) by attenuating transforming growth factor-beta 1 (TGF-β1)-induced ECM expression, cell contraction and myofibroblast differentiation. Unexpectedly, neither genetic silencing of PIK3C3 nor other PIK3C3 inhibitors (e.g., …

Applying A Modern Situational Measure To Improve The Reliability, Validity, And Outcome Predictability Of Dream Assessment, Odalis Garcia

Psychology

Dreams are hallucinatory activity occurring during sleep that nearly everyone experiences. To understand and research dreams, the field needs a reliable and valid dream assessment tool. The current, most used, measure (Hall and Van de Castle measure) has presented with various reliability and validity issues since its development in 1966. I propose adapting the DIAMONDS taxonomy for situational characteristics to assess dream content. The validation process of this adapted measure has begun with foundational work informing the development of dream-specific subscales. In two preliminary studies I provide some evidence for substantive and structural validity of the adapted measure. Interim data …

Improving Nitrogen Management, Including The Use Of Cover Crops, In North Dakota Cropping Systems, Brady Goettl

Natural Resources Management

Crop production in North Dakota covers nearly 64 million ha, playing a crucial role in the state’s economy. However, wide-spread agriculture also poses environmental risks resulting from soil erosion and loss of N to ground and surface water. To address these concerns, agriculturists must adopt practices to decrease soil erosion and responsibly manage N. Between 2020 and 2024, several studies in North Dakota focused on improving N management in two-row malting barley (Hordeum vulgare L.), explored opportunities for cover crop integration, and assessed the rotational impact cover crops on crop productivity and soil factors. Research indicated N recommendations ranging from …

The Experiences Of Women College Presidents While Leading Through An Institutional Crisis: The Perceived Successes And Failures Of Crisis Communication Strategies, Madison Marie Speck

Graduate Theses, Dissertations, and Problem Reports (ETD)

This multi-site case study explored the uncommonly discussed yet organic intersection between the study of crisis communication and the study of crisis leadership and in turn, what it means in the context of a college presidency. This study has a unique focus on women presidents at small, private colleges and the ways in which they communicate with various stakeholders during a crisis environment. The research is guided by Boin’s Model of Crisis Leadership which guides and assesses crisis leadership performance; however this study introduces nuances to the framework that are suggested as a result of the findings; most of which …

Subjective Cognitive Decline: Examining The Contributions Of Adverse Childhood Experiences And Social Determinants Of Health, Amber Victoria Rusch

Graduate Theses, Dissertations, and Problem Reports (ETD)

Subjective cognitive decline is one’s awareness of their own consistent memory loss or confusion that interrupts their day-to-day activities (CDC, 2022; Roehr et al., 2017). Several risk factors for subjective cognitive decline, such as demographic social determinants of health (SDOH) and adverse childhood experiences (ACEs) have been identified through previous research (Alzheimer’s Association, 2016; Dening & Sandilyan, 2015); however, less is known about the interaction between demographic SDOH and ACEs on subjective cognitive decline. The current study sought to examine how demographic SDOH (i.e., age, sex, race, and education) (research question 1) and ACEs (i.e., physical abuse, sexual abuse, and …

An Assessment Of Barriers To Nurse Practitioners’ Utilizing Pharmacogenetic Testing For Depression, Sierra Entzel

Nursing

As a leading cause of disability worldwide, depression is considered a chronic disease. Medication management is the first-line treatment for moderate to severe major depressive disorder. Medications are selected based on provider experience and preference with a trial-and- error” approach. These medications may take several weeks to reach therapeutic dosing. If it is not tolerated or ineffective for treating the disease, then the medication regimen is changed, requiring a minimum of 4-6 weeks to determine efficacy. This trial-and-error approach to depression treatment can lead to patients living with persistently debilitating depressive symptoms for months, increased healthcare costs due to continued …

The Relationship Between Moral Thought-Action Fusion And Scrupulosity Across Judaism, Christianity, And Islam, Kelsey Evey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Scrupulosity is a subtype of obsessive-compulsive disorder (OCD) where individuals are upset by intrusive thoughts related to religious or moral issues. Current research suggests that scrupulosity occurs across the major world religions—including the Abrahamic religions (i.e., Judaism, Christianity, and Islam). Some research suggests that moral thought-action fusion (moral TAF), a dysfunctional belief that thinking something is equal to doing it, may only be pathological under certain circumstances (e.g., if it is not culturally normative). If this is true, the current cognitive model of scrupulosity may need to be amended to reflect how cultural differences impact the role of moral TAF …

Implementation Of The Academic Autistic Spectrum Partnership In Research And Education (Aaspire)-Based Guidelines To Improve Perioperative Care Of Patients With Autism Spectrum Disorder, Kayleigh Brink

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Implementation of the Academic Autistic Spectrum Partnership in Research and Education (AASPIRE)-based Guidelines to Improve Perioperative Care of Patients with Autism Spectrum Disorder

Kayleigh Brink

Introduction: Autism Spectrum Disorder (ASD) is becoming more prevalent with an increasing need to identify and eliminate barriers to care. Healthcare Providers (HCP) have shown limited knowledge and confidence when managing patients with ASD. The inability to provide specialized care and recognize symptoms of pain or discomfort could result in behavioral difficulties.

Purpose: The purpose of this project was to improve confidence among HCPs to identify ASD characteristics and to improve the use of …

Advance Care Planning: Implementing Online Education For Rural Primary Care Providers, Jessica Kurtz

Nursing

Advance care planning (ACP) can assist patients and their families in navigating personal and medical choices at the end-of-life; however, these conversations often transpire too late. Primary care providers (PCPs) frequently develop extended relationships with their patients, especially those with chronic disease, and possess opportunities throughout a patient’s lifespan to assess when ACP conversations could be initiated. Unfortunately, many PCPs lack confidence in leading ACP conversations, although they are willing to facilitate them. Despite the alarming number of people living with chronic disease and documented benefits of ACP, advance directive completion remains low. According to previous research, online ACP education …

Emergency Provider Education For Management Of Patients With Suicidal Ideation In Rural Minnesota, Stephanie Slivnik

Nursing

This dissertation investigated the efficacy of an educational intervention aimed at enhancing the management of patients with suicidal ideation in a rural emergency department. Employing a quasi-experimental mixed-method design, the study involved an educational session, administration of online pre-, post-, and post three-month surveys, and an electronic health record review. The data was then compared to determine if provider confidence was impacted by education. The educational session, guided by the ICAR²E mnemonic developed by Wilson et al. (2020), encompassed components focused on identifying suicide risk, effective communication with patients, assessment for life-threatening conditions, risk assessment, strategies to reduce suicide risk, …

The Function Of Protein Glutamylation In Vision, Rawaa Aljammal

Graduate Theses, Dissertations, and Problem Reports (ETD)

Posttranslational glutamylation of protein has emerged as a novel candidate for cellular integrity. In a dynamic process, Tubulin Tyrosine Ligase Like proteins (TTLLs) introduce glutamate groups to their substrates, while Cytosolic Carboxypeptidases members (CCP1-CCP6) remove these glutamate groups. The outcome of this interplay is a wide range of substrates; each is glutamylated to a level crucial for its function.

Protein glutamylation is particularly abundant in neurons and in the axoneme of cilia and flagella. This distribution, along with the correlation between imbalanced glutamylation levels and compromised cellular functions, underscores the significance of protein glutamylation in maintaining cellular viability. However, the …

Parental Socialization Of General And Domain-Specific Self-Control In Adolescents, Matty Johnston

Graduate Theses, Dissertations, and Problem Reports (ETD)

Adolescent self-control appears to be an important competency to develop. It has pervasive links with various outcomes (e.g., educational, financial, and interpersonal) both during adolescence and into adulthood (Allemand et al., 2019, Moffitt et al., 2011). Adolescents often report lower self-control compared to adults, although individual levels of self-control vary widely between adolescents (Allemand et al., 2019, Romer et al., 2010). Despite its importance, very little is known about how self-control develops. Thus, the current study aims to examine the relationship between parents’ self-control and that of their teen children. To further understand how adolescents' self-control may be socialized by …

Dermoscopy Education To Improve Provider Confidence In Skin Cancer Identification, Hayli Ova

Nursing

Skin cancer is the most common form of cancer in the United States and is becoming more prevalent each year. Patients often consult their primary care provider (PCP) for initial evaluation of skin lesions, and PCPs typically use naked-eye examination (NEE) to evaluate the lesion. Using NEE alone can yield varying results of accuracy and differential diagnosis. PCPs can utilize a dermatoscope to aid their visual inspection of suspicious lesions. Dermoscopy, a non-invasive technique for examining skin lesions, has been recognized as an invaluable tool in the early detection of skin cancer. While traditionally used by dermatologists, the need for …

Factors That Influence Plans To Have Children: An Application Of The Theory Of Planned Behavior To Fertility Decision-Making Across The Reproductive Years, Amanda Chappell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Fertility intentions include plans to have one or more children; intentions can be used to predict fertility behavior. The focus of the current study was to examine the influence of age and gender on factors involved in estimating fertility intentions (measured with 5 items), including attitudes (i.e., how one feels about becoming a parent; 13 items), norms (i.e., pressure from important others to have children; 5 items), and perceived control (beliefs about capability of becoming a parent; 4 items) in a U.S. sample. The study included a sample of N = 289 (51% men) participants (75.6% White) between the ages …

Treatment Patterns And Clinical And Economic Burden In Patients With Merkel Cell Carcinoma: Statistical And Machine Learning Approaches, Yves Mbous

Graduate Theses, Dissertations, and Problem Reports (ETD)

Although considered a rare form of nonmelanoma skin cancer, Merkel Cell Carcinoma incidence rate has increased to 0.74 per 100,000 and projections expect this number to steadily rise over the next decades and to reach an average of 3,285 cases per year in 2025. MCC incidence increases significantly with age. Among those aged 40-44, it is 0.44, it rises to 1.0/100,000 in the 60-64 age group and soars to 9.8/100,000 among those ≥85 years and above. Due to the small number of cases, MCC is often managed using institutional practices or provider preferences. Formal clinical trials that enroll early stage …

Intervention To Reduce Tobacco Use Among Prostate Cancer Patient And Informal Caregiver Dyads, Trupti Dhumal

Graduate Theses, Dissertations, and Problem Reports (ETD)

Prostate cancer is the leading cancer in men. Continued tobacco use after prostate cancer diagnosis may affect a patient’s treatment outcomes, quality of life, and mortality. Despite the potential negative outcomes, 10-20% of prostate cancer patients continue to use tobacco after their cancer diagnosis. Considering risks associated with continued tobacco use, there is a lack of evidence-based tobacco cessation strategies to address tobacco cessation specifically in prostate cancer. Given the increasing prevalence of prostate cancer, the ongoing difficulty in tobacco cessation, and the limited evidence-based tobacco cessation interventions in the literature, it is important to prioritize reducing tobacco use in …

Abuse Liability Of Electronic Cigarettes In Non-Smoking Electronic Cigarette Users, Andrea Renee Milstred

Graduate Theses, Dissertations, and Problem Reports (ETD)

Electronic cigarettes (ECIGs) are devices designed to aerosolize nicotine and are increasing in popularity among both former cigarette smokers and naïve tobacco users. Extant research has shown the dependence potential of ECIGs, though there is not a consensus on the severity of nicotine dependence caused by ECIG use. As a result of becoming dependent on nicotine, individuals may experience withdrawal symptoms (i.e., irritable, craving, depressed mood) when abstaining from nicotine. The majority of previous research on ECIG use has included samples of ECIG users who are former or current smokers. The present study evaluated ECIG withdrawal suppression among a population …

Empowering Inclusive Mobility: Addressing Team Challenges And Advancing Solutions For Deaf Communities In Rural West Virginia Through Innovative Engineering And Collaborative Initiatives, Morgan Elaine Bartley

Graduate Theses, Dissertations, and Problem Reports (ETD)

This report provides an overview of the strategic initiatives, challenges, and future considerations encountered by the West Virginia University (WVU) EcoCAR Team in their mission to enhance accessibility for deaf and hard-of-hearing individuals in rural West Virginia, with a specific focus on improving the Cadillac LYRIQ's features. The report delves into the stakeholder profile, encompassing demographic characteristics and mobility challenges unique to the target population, while also highlighting the team's SMART goals, key challenges faced, and forward-looking strategies to better the team.

The WVU EcoCAR Team's mission revolves around addressing mobility barriers for the deaf and hard-of-hearing community in rural …

The Names Of All Wild Things: Field Guides And Environmental Thinking, Frank Izaguirre Phd

Graduate Theses, Dissertations, and Problem Reports (ETD)

The project first traces the earliest origins of natural history writing, surveying how natural history writing from antiquity presented and categorized the living world, and then how the rise of print culture and growing popularity of natural history writing would facilitate the rise of European empires. Values and conventions emerged that would later feed into the field guide, like the pairing of text and illustration to aid identification and the decontextualizing of plants and animals from their environments.

Near the end of the nineteenth century, the field guide genre emerged. Some wildly popular books, mostly written by women, emphasized the …

Life After Sport: A Program Development Plan For Student-Athletes, Loryn Shawn Frame

Graduate Theses, Dissertations, and Problem Reports (ETD)

College athletics stakeholders have had growing concerns regarding student-athletes’ transition out of collegiate athletics. Research specific to student-athletes following college athletics has explored mental health, role identity, and occupational participation. This program development plan addresses occupational therapy’s role in assisting student-athletes transition out of collegiate athletics. The needs assessment conducted with West Virginia University athletic staff revealed two gaps in programming: athletic identity including leisure exploration, and a program to help student-athletes who want to enter health professional programs. Life After Sport comprises two programs, one to help student-athletes transition into a health professional program, titled Athletes in Medicine (AIM), …

The Line Between Man And Monster: A Theatrical Costume Design Of Caryl Churchill's The Skriker, Katrina Anne Lundquist

Graduate Theses, Dissertations, and Problem Reports (ETD)

Produced at West Virginia University, this is a record of the costume design process for The Skriker by Caryl Churchill. As a play about vicious folkloric faerie creatures in modern day England, there was a heavy emphasis on showcasing the difference between the human and fae characters. With such a fantastical script, there is a potential to take the design down any number of creative paths. Finding a way to cohesively costume the cast while not losing the intricacies of their individual stories became a personal priority. After coming to an agreement with the director and the rest of the …