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Articles 73861 - 73890 of 80367
Full-Text Articles in Entire DC Network
Beyond Heteronormativity And The Gender Binary: Inclusivity In Rape Myth Acceptance Scale Design And Sexual Violence Bystander Intervention Programming, Melanie Fierstine
Beyond Heteronormativity And The Gender Binary: Inclusivity In Rape Myth Acceptance Scale Design And Sexual Violence Bystander Intervention Programming, Melanie Fierstine
Education
Sexual violence perpetuates inequalities based on a range of factors such as gender, race/ethnicity, class, age, sexuality, and ability status. However, the study of sexual violence in these areas has been limited leading to a lack of knowledge about its role in perpetuating social inequality. Understanding bystander intervention and its effects on violence prevention is complex and unclear. Three studies were conducted to investigate the use of language in the Green Dot Violence Prevention programming and the design of a sex and gender-inclusive rape myth acceptance scale. Study 1 employs Critical Discourse Analysis to analyze the language used in the …
Potential Use Of Poultry Farms By Wild Waterfowl In California's Central Valley Varies Across Space, Times Of Day, And Species: Implications For Influenza Transmission Risk, Claire S. Teitelbaum, Michael L. Casazza, Cory T. Overton, Jeffery D. Sullivan, Elliott L. Matchett, Fiona Mcduie, Austen A. Lorenz, Joshua T. Ackerman, Susan E.W. De La Cruz, Diann J. Prosser
Potential Use Of Poultry Farms By Wild Waterfowl In California's Central Valley Varies Across Space, Times Of Day, And Species: Implications For Influenza Transmission Risk, Claire S. Teitelbaum, Michael L. Casazza, Cory T. Overton, Jeffery D. Sullivan, Elliott L. Matchett, Fiona Mcduie, Austen A. Lorenz, Joshua T. Ackerman, Susan E.W. De La Cruz, Diann J. Prosser
Faculty Research, Scholarly, and Creative Activity
Interactions between wildlife and livestock can lead to cross-species disease transmission, which incurs economic costs and threatens wildlife conservation. Wild waterfowl are natural hosts of avian influenza viruses (AIVs), are often abundant near poultry farms, and have been linked to outbreaks of AIVs in poultry. Interspecific and seasonal variation in waterfowl movement and habitat use means that the risk of disease transmission between wild birds and poultry inevitably varies across species, space, and time. Here, we used GPS telemetry data from 10 waterfowl species in and near California's Central Valley, a region where both wild waterfowl and domestic poultry are …
Modeling The Effect Of Observational Social Learning On Parental Decision-Making For Childhood Vaccination And Diseases Spread Over Household Networks, Tamer Oraby, Andras Balogh
Modeling The Effect Of Observational Social Learning On Parental Decision-Making For Childhood Vaccination And Diseases Spread Over Household Networks, Tamer Oraby, Andras Balogh
School of Mathematical & Statistical Sciences Faculty Publications
In this paper, we introduce a novel model for parental decision-making about vaccinations against a childhood disease that spreads through a contact network. This model considers a bilayer network comprising two overlapping networks, which are either Erdős–Rényi (random) networks or Barabási–Albert networks. The model also employs a Bayesian aggregation rule for observational social learning on a social network. This new model encompasses other decision models, such as voting and DeGroot models, as special cases. Using our model, we demonstrate how certain levels of social learning about vaccination preferences can converge opinions, influencing vaccine uptake and ultimately disease spread. In addition, …
Exploring International Educators' Learning About Local And Global Social Justice In A Virtual Community Of Practice, Bima Sapkota, Xuwei Luo, Muna Sapkota, Murat Akarsu, Emmanuel Deogratias, Daphne Fauber, Rose Mbewe, Fidelis Mumba, Ram Krishna Panthi, Jill Newton
Exploring International Educators' Learning About Local And Global Social Justice In A Virtual Community Of Practice, Bima Sapkota, Xuwei Luo, Muna Sapkota, Murat Akarsu, Emmanuel Deogratias, Daphne Fauber, Rose Mbewe, Fidelis Mumba, Ram Krishna Panthi, Jill Newton
School of Mathematical & Statistical Sciences Faculty Publications
In this chapter, the authors report themes that emerged when a cross-cultural team of researchers involved in a virtual international community of practice (Global Social Justice in Education-GSJE) investigated reflections on activities focused on social justice in local and global contexts. The findings suggested that the activities elicited GSJE community members' understandings of the complexities of social justice associated with naming practices, privilege, and the arts within their own and across contexts. The authors discuss implications of the activities to advance diverse educators' understanding of social justice in global and local contexts. They also unpack the opportunities and challenges that …
Assessing Concepts, Procedures, And Cognitive Demand Of Chatgpt-Generated Mathematical Tasks, Bima Sapkota, Liza Bondurant
Assessing Concepts, Procedures, And Cognitive Demand Of Chatgpt-Generated Mathematical Tasks, Bima Sapkota, Liza Bondurant
School of Mathematical & Statistical Sciences Faculty Publications
In November 2022, ChatGPT, an Artificial Intelligence (AI) large language model (LLM) capable of generating human-like responses, was launched. ChatGPT has a variety of promising applications in education, such as using it as thought-partner in generating curricular resources. However, scholars also recognize that the use of ChatGPT raises concerns, such as outputs that are inaccurate, nonsensical, or vague. We, two mathematics teacher educators, engaged in a collaborative self-study using qualitative descriptive approaches to investigate the procedures, concepts, and cognitive demand of ChatGPT-generated mathematical tasks focused on fraction multiplication using the area model approach. We found that the ChatGPT-generated tasks were …
Impact Of Successful Recanalization And Clinical Outcomes Of Patients With Acute Ischemic Stroke With 5 Or More Thrombectomy Passes, Kazutaka Uchida, Mohammad-Mahdi Sowlat, Hidetoshi Matsukawa, Sameh Samir Elawady, Ali Alawieh, Conor Cunningham, Sami Al Kasab, Ilko Maier, Pascal Jabbour, Joon-Tae Kim, Stacey Quintero Wolfe, Ansaar Rai, Robert M Starke, Marios-Nikos Psychogios, Amir Shaban, Adam Arthur, Hugo Cuellar, Jonathan A Grossberg, Daniele G Romano, Omar Tanweer, Justin Mascitelli, Isabel Fragata, Adam Polifka, Joshua Osbun, Roberto Crosa, Charles Matouk, Min S Park, Michael R Levitt, Waleed Brinjikji, Mark Moss, Richard Williamson, Pedro Navia, Peter Kan, Reade De Leacy, Shakeel Chowdhry, Mohamad Ezzeldin, Shinichi Yoshimura, Alejandro M Spiotta, Stroke Thrombectomy And Aneurysm Registry (Star) Collaborators
Impact Of Successful Recanalization And Clinical Outcomes Of Patients With Acute Ischemic Stroke With 5 Or More Thrombectomy Passes, Kazutaka Uchida, Mohammad-Mahdi Sowlat, Hidetoshi Matsukawa, Sameh Samir Elawady, Ali Alawieh, Conor Cunningham, Sami Al Kasab, Ilko Maier, Pascal Jabbour, Joon-Tae Kim, Stacey Quintero Wolfe, Ansaar Rai, Robert M Starke, Marios-Nikos Psychogios, Amir Shaban, Adam Arthur, Hugo Cuellar, Jonathan A Grossberg, Daniele G Romano, Omar Tanweer, Justin Mascitelli, Isabel Fragata, Adam Polifka, Joshua Osbun, Roberto Crosa, Charles Matouk, Min S Park, Michael R Levitt, Waleed Brinjikji, Mark Moss, Richard Williamson, Pedro Navia, Peter Kan, Reade De Leacy, Shakeel Chowdhry, Mohamad Ezzeldin, Shinichi Yoshimura, Alejandro M Spiotta, Stroke Thrombectomy And Aneurysm Registry (Star) Collaborators
Faculty, Staff and Students Publications
Background: As the number of thrombectomy passes increases during endovascular therapy (EVT) for acute stroke, neurointerventionalists must weigh the risks of potential complications against the risk of failing to recanalize the affected vessel. Thus, we investigated the effectiveness and safety of EVT for patients with acute stroke in which ≥5 EVT passes were performed.
Methods: This retrospective cohort study from January 2013 to December 2022 included 31 thrombectomy-capable centers. Patients in whom ≥5 EVT passes were made were included in the analysis. The patients with successful recanalization defined as modified Thrombolysis in Cerebral Infarction ≥2b at 5, 6, 7, or …
Ivermectin, Colleen Aldous, Eleftherios Gkioulekas, Philip Oldfield
Ivermectin, Colleen Aldous, Eleftherios Gkioulekas, Philip Oldfield
School of Mathematical & Statistical Sciences Faculty Publications
No abstract provided.
Developing A Community Engaged Covid-19 Education Campaign, L. Lynette Parker, Martha I. Arrieta Phd
Developing A Community Engaged Covid-19 Education Campaign, L. Lynette Parker, Martha I. Arrieta Phd
Community Engagement Posters
Purpose: We sought to define, evaluate, and disseminate a set of essential COVID health literacy messages to help community members wisely navigate COVID-19 exposures, risks, and diagnoses as COVID-19 enters its endemic phase.
Design Methods: Key Informant interviews with medical professionals and Focus Groups (FG) with community members identified critical COVID-19 health education areas. Evidence-based initial messages were developed for each educational area. Another round of community member FGs evaluated the messages for relevance, value, and clarity. Community surveys are being deployed to gauge broad knowledge of the messages prior to implementation of a tailored dissemination campaign.
Results/Expected Results …
Systemic Complications Of Aicardi Goutières Syndrome Using Real-World Data, Isabella Peixoto De Barcelos, Amanda K Jan, Nicholson Modesti, Sarah Woidill, Francesco Gavazzi, David Isaacs, Russell D'Aiello, Anjana Sevagamoorthy, Lauren Charlton, Amy Pizzino, Johanna Schmidt, Keith Van Haren, Stephanie Keller, Florian Eichler, Lisa T Emrick, Jamie L Fraser, Justine Shults, Adeline Vanderver, Laura A Adang
Systemic Complications Of Aicardi Goutières Syndrome Using Real-World Data, Isabella Peixoto De Barcelos, Amanda K Jan, Nicholson Modesti, Sarah Woidill, Francesco Gavazzi, David Isaacs, Russell D'Aiello, Anjana Sevagamoorthy, Lauren Charlton, Amy Pizzino, Johanna Schmidt, Keith Van Haren, Stephanie Keller, Florian Eichler, Lisa T Emrick, Jamie L Fraser, Justine Shults, Adeline Vanderver, Laura A Adang
Faculty, Staff and Students Publications
Objective: Aicardi Goutières Syndrome (AGS) is a rare genetic interferonopathy associated with diverse multisystemic complications. A critical gap exists in our understanding of its longitudinal, systemic disease burden, complicated by delayed diagnosis. To address this need, real-world data extracted from existing medical records were used to characterize the longitudinal disease burden.
Methods: All subjects (n = 167) with genetically confirmed AGS enrolled in the Myelin Disorders Biorepository Project (MDBP) were included. As available in medical records, information was collected on subject demographics, age of onset, and disease complications. Information from published cases of AGS (2007-2022; n = 129) with individual-level …
Diagnostic Accuracy Of Urinary N Terminal Pro-B Type Natriuretic Peptides For Hemodynamically Significant-Patent Ductus Arteriosus In Preterm Infants, Srirupa Hari Gopal, Ganga Gokulakrishnan, Madhulika Kulkarni, Caraciolo J Fernandes, Mohan Pammi
Diagnostic Accuracy Of Urinary N Terminal Pro-B Type Natriuretic Peptides For Hemodynamically Significant-Patent Ductus Arteriosus In Preterm Infants, Srirupa Hari Gopal, Ganga Gokulakrishnan, Madhulika Kulkarni, Caraciolo J Fernandes, Mohan Pammi
Faculty, Staff and Students Publications
Background: Echocardiography is the gold standard for the diagnosis hemodynamically significant-patent ductus arteriosus (hs-PDA). It requires trained personnel and is not readily available. Urinary biomarkers can be used as an adjunct.
Objective: The objective of this study was to systematically review the diagnostic accuracy of urinary N terminal pro-B type natriuretic peptides (NT-proBNP) for hs-PDA in preterm neonates.
Methods: We included studies that evaluated urinary NT-proBNP and urinary NT-proBNP/creatinine ratio (index tests) in preterm neonates with hs-PDA (participants) in comparison with echocardiogram (reference standard). Methodological quality and certainty of evidence were assessed using Quality Assessment of Diagnostic-Accuracy Studies (QUADAS-2) and …
Examining The Utility Of The Early Childhood Development Index (Ecdi) Among 3- To 4-Year-Olds In The Nigeria Context, Ngozi V. Enelamah, Smitha Rao, Margaret Lombe, Mansoo Yu, Chrisann Newransky, Melissa L. Villodas, Andrew Foell, Von Nebbitt
Examining The Utility Of The Early Childhood Development Index (Ecdi) Among 3- To 4-Year-Olds In The Nigeria Context, Ngozi V. Enelamah, Smitha Rao, Margaret Lombe, Mansoo Yu, Chrisann Newransky, Melissa L. Villodas, Andrew Foell, Von Nebbitt
Faculty Publications
An estimated six million of over 31 million children under five years old are at risk of not reaching their full developmental potential in Nigeria. There is a need for culturally appropriate and context-specific measures to track child development and facilitate intervention planning. This study assessed the utility of the Early Childhood Development Index (ECDI), see Table 1, used in the 2016/2017 round of the Multiple Indicator Cluster Survey (MICS) to track development among 3- to 4-year-old children (n=11,073; 3-year-old, 51%; female, 49%).
Emulating A Randomized Clinical Trial With Real-World Data To Evaluate The Effect Of Antidepressant Use In Ptsd Patients With High Suicide Risk, Oshin Miranda, Xiguang Qi, M Daniel Brannock, Ryan Whitworth, Thomas Kosten, Neal David Ryan, Gretchen L Haas, Levent Kirisci, Lirong Wang
Emulating A Randomized Clinical Trial With Real-World Data To Evaluate The Effect Of Antidepressant Use In Ptsd Patients With High Suicide Risk, Oshin Miranda, Xiguang Qi, M Daniel Brannock, Ryan Whitworth, Thomas Kosten, Neal David Ryan, Gretchen L Haas, Levent Kirisci, Lirong Wang
Faculty, Staff and Students Publications
INTRODUCTION: Post-Traumatic Stress Disorder (PTSD) entails behavioral changes with increased risk of suicide, and there is no consensus on the preferred antidepressants for treatment of those PTSD patients who are at elevated risk for suicide.
METHODS: We conducted a clinical trial emulation study comparing suicide-related events (SREs) among those patients' initiating antidepressants within 60 days after a qualifying SRE. Patients were followed from initiation of antidepressant until any of the following: treatment cessation, switching, death, or loss to follow-up. The outcome is a new onset of an SRE.
RESULTS: Citalopram exhibited a significantly fewer case with new SREs compared to …
The Intersection Of Gender, Caregiving, And Research Productivity During The Covid-19 Pandemic: A Multi-Method Study, Elizabeth A. Moschella-Smith, Sharyn J. Potter
The Intersection Of Gender, Caregiving, And Research Productivity During The Covid-19 Pandemic: A Multi-Method Study, Elizabeth A. Moschella-Smith, Sharyn J. Potter
Faculty Publications
The COVID-19 pandemic differentially impacted the productivity of women researchers with children compared to men, with and without children. The purpose of the present study was to examine the relationship between gender, caregiving responsibilities, and research productivity before and during the pandemic. We quantitatively and qualitatively analyzed survey (n=227) and follow-up interview data (n=44) collected from faculty and staff at a Carnegie Classification Research 1 public university. Findings suggest that women researchers with children faced increased caregiving demands and diminished research productivity during the pandemic, compared to men with children and researchers without children. As illustrated by the qualitative data, …
Group-Based Interventions In Lifestyle Medicine, Viet T Tran, Elizabeth M Vaughan, Stephanie Kim, Craig A Johnston
Group-Based Interventions In Lifestyle Medicine, Viet T Tran, Elizabeth M Vaughan, Stephanie Kim, Craig A Johnston
Faculty, Staff and Students Publications
Group-based interventions in health care have demonstrated a positive influence on patient outcomes by strengthening patient-healthcare professional relationships and providing an avenue for patient empowerment through shared experiences and belongingness. Groups have been shown to enhance social and psychological support, improve self-management behaviors, and encourage peer-support. However group settings also present challenges, such as discomforts in sharing within a group context and managing diverse group dynamics. We outline the efficacy and dynamics of group-based activities in health care settings. This includes key behavioral components of groups, such as creating a safe, supportive, and cohesive environment in group activities where confidentiality …
Reproductive Factors And Their Association With Physical And Comprehensive Frailty In Middle-Aged And Older Women: A Large-Scale Population-Based Study, Wenting Hao, Qi Wang, Ruihong Yu, Shiva Raj Mishra, Salim S Virani, Nipun Shrestha, Chunying Fu, Dongshan Zhu
Reproductive Factors And Their Association With Physical And Comprehensive Frailty In Middle-Aged And Older Women: A Large-Scale Population-Based Study, Wenting Hao, Qi Wang, Ruihong Yu, Shiva Raj Mishra, Salim S Virani, Nipun Shrestha, Chunying Fu, Dongshan Zhu
Faculty, Staff and Students Publications
Study question: Are women's reproductive factors associated with physical frailty and comprehensive frailty in middle-age and later life?
Summary answer: Early menarche at < 13 years, age at menopause < 45 years, surgical menopause, experiencing miscarriage and a shorter reproductive period of < 35 years were associated with increased odds of frailty, while having two or three children was related to decreased likelihood of frailty.
What is known already: Evidence has shown that women are frailer than men in all age groups and across different populations, although women have longer lifespans. Female-specific reproductive factors may be related to risk of frailty in women.
Study design size duration: A population-based cross-sectional study involved 189 898 women from the UK Biobank.
Participants/materials setting methods: Frailty phenotype and frailty index were used to assess physical frailty and comprehensive frailty (assessed using 38 health indicators for …
Understanding Prescribing Practices And Patient Experiences With Renin Angiotensin System Inhibitors Use In Chronic Kidney Disease: A Qualitative Study, Jennifer Arney, L Parker Gregg, Sheena Wydermyer, Michael A Herrera, Peter A Richardson, Michael E Matheny, Julia M Akeroyd, Glenn T Gobbel, Adriana Hung, Salim S Virani, Sankar D Navaneethan
Understanding Prescribing Practices And Patient Experiences With Renin Angiotensin System Inhibitors Use In Chronic Kidney Disease: A Qualitative Study, Jennifer Arney, L Parker Gregg, Sheena Wydermyer, Michael A Herrera, Peter A Richardson, Michael E Matheny, Julia M Akeroyd, Glenn T Gobbel, Adriana Hung, Salim S Virani, Sankar D Navaneethan
Faculty, Staff and Students Publications
Introduction: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) improve outcomes but are underutilized in patients with chronic kidney disease (CKD). Little is known about reasons for discontinuation and lack of reinitiating these medications. We aimed to explore clinicians' and patients' experiences and perceptions of ACEI/ARB use in CKD.
Methods: A multi-profession sample of health care clinicians and patients with documented ACEI/ARB-associated side effects in the past 6 months. Participants were recruited from 2 Veterans Affairs healthcare systems in Texas and Tennessee. A total of 15 clinicians and 10 patients completed interviews. We used inductive and deductive qualitative data …
Understanding Primary Care Physician Perspectives On The Diagnosis And Management Of Non-Alcoholic Fatty Liver Disease: A Qualitative Study, Natalia I Heredia, Jemima C John, Sonia Singh, Jessica P Hwang, Larkin L Strong, Maya Balakrishnan, Lorna H Mcneill
Understanding Primary Care Physician Perspectives On The Diagnosis And Management Of Non-Alcoholic Fatty Liver Disease: A Qualitative Study, Natalia I Heredia, Jemima C John, Sonia Singh, Jessica P Hwang, Larkin L Strong, Maya Balakrishnan, Lorna H Mcneill
Faculty, Staff and Students Publications
Primary care physicians (PCPs) are well suited to manage patients with non-alcoholic fatty liver disease (NAFLD), but the limited, existing research suggests inadequate knowledge about the natural history, diagnostic methods, and management of NAFLD. The purpose of this qualitative study is to further understand the knowledge and practices for the diagnosis and management of NAFLD among PCPs. We conducted in-depth interviews with PCPs in the Greater Houston area, addressing current clinical practices used for diagnosing and managing NAFLD, as well as the perceptions of the PCPs regarding the burden of NAFLD on patients. We recorded interviews, transcribed them, coded transcripts, …
Characteristics And Contributing Factors Of Diagnostic Error In Surgery: Analysis Of Closed Medico-Legal Cases And Complaints In Canada, Janice L Kwan, Lisa A Calder, Cara L Bowman, Anna Macintyre, Richard Mimeault, Liisa Honey, Cynthia Dunn, Gary Garber, Hardeep Singh
Characteristics And Contributing Factors Of Diagnostic Error In Surgery: Analysis Of Closed Medico-Legal Cases And Complaints In Canada, Janice L Kwan, Lisa A Calder, Cara L Bowman, Anna Macintyre, Richard Mimeault, Liisa Honey, Cynthia Dunn, Gary Garber, Hardeep Singh
Faculty, Staff and Students Publications
Background: Diagnostic errors lead to patient harm; however, most research has been conducted in nonsurgical disciplines. We sought to characterize diagnostic error in the pre-, intra-, and postoperative surgical phases, describe their contributing factors, and quantify their impact related to patient harm.
Methods: We performed a retrospective analysis of closed medico-legal cases and complaints using a database representing more than 95% of all Canadian physicians. We included cases if they involved a legal action or complaint that closed between 2014 and 2018 and involved a diagnostic error assigned by peer expert review to a surgeon.
Results: We identified 387 surgical …
Preclinical Evaluation Of A Novel Antibiotic-Eluting Bioenvelope For Cied Infection Prevention, Zerelda Esquer Garrigos, John N Catanzaro, Daniel Deegan, Ji Zhang, M Rizwan Sohail
Preclinical Evaluation Of A Novel Antibiotic-Eluting Bioenvelope For Cied Infection Prevention, Zerelda Esquer Garrigos, John N Catanzaro, Daniel Deegan, Ji Zhang, M Rizwan Sohail
Faculty, Staff and Students Publications
The risk of infection remains a significant concern with cardiovascular implantable electronic devices, necessitating the development of new strategies. This study explores the efficacy of a novel antibiotic-eluting biologic envelope designed to mitigate infection risk through localized antibiotic delivery while preserving the regenerative properties of biological matrix. Antibiotics, rifampin and minocycline, are released through polymer discs, ensuring extended drug release. Utilizing an established model of infection in a New Zealand White rabbit, the study assessed performance against Gram-positive bacterial strains, including common pathogens such as Staphylococcus aureus and S. epidermidis associated with CIED infections, and Gram-negative bacterial strains. Results demonstrated …
Dimensionality Reduction And Nearest Neighbors For Improving Out-Of-Distribution Detection In Medical Image Segmentation, Mckell Woodland, Nihil Patel, Austin Castelo, Mais Al Taie, Mohamed Eltaher, Joshua P Yung, Tucker J Netherton, Tiffany L Calderone, Jessica I Sanchez, Darrel W Cleere, Ahmed Elsaiey, Nakul Gupta, David Victor, Laura Beretta, Ankit B Patel, Kristy K Brock
Dimensionality Reduction And Nearest Neighbors For Improving Out-Of-Distribution Detection In Medical Image Segmentation, Mckell Woodland, Nihil Patel, Austin Castelo, Mais Al Taie, Mohamed Eltaher, Joshua P Yung, Tucker J Netherton, Tiffany L Calderone, Jessica I Sanchez, Darrel W Cleere, Ahmed Elsaiey, Nakul Gupta, David Victor, Laura Beretta, Ankit B Patel, Kristy K Brock
Faculty, Staff and Students Publications
Clinically deployed deep learning-based segmentation models are known to fail on data outside of their training distributions. While clinicians review the segmentations, these models tend to perform well in most instances, which could exacerbate automation bias. Therefore, detecting out-of-distribution images at inference is critical to warn the clinicians that the model likely failed. This work applied the Mahalanobis distance (MD) post hoc to the bottleneck features of four Swin UNETR and nnU-net models that segmented the liver on T1-weighted magnetic resonance imaging and computed tomography. By reducing the dimensions of the bottleneck features with either principal component analysis or uniform …
Editorial: Managing Cancer Metastasis By Tackling Anticancer Drug Resistance, Erxi Wu, Zhongzhi Wu, Chao-Yie Yang, Dan Qi, Xiaoxiao Hu, Wei Li
Editorial: Managing Cancer Metastasis By Tackling Anticancer Drug Resistance, Erxi Wu, Zhongzhi Wu, Chao-Yie Yang, Dan Qi, Xiaoxiao Hu, Wei Li
Faculty, Staff and Students Publications
No abstract provided.
Triiodothyronine Acts On Dao To Regulate Pulmonary Fibrosis Progression By Facilitating Cell Senescence Through The P53/P21 Signaling Pathway, Xiaoshu Guo, Kai Xu, Lan Wang, Linke Ding, Wenwen Li, Xinsheng Zhang, Weiming Zhao, Ningdan Wang, Gaiping Wang, Wenyu Zhao, Ivan Rosas, Guoying Yu
Triiodothyronine Acts On Dao To Regulate Pulmonary Fibrosis Progression By Facilitating Cell Senescence Through The P53/P21 Signaling Pathway, Xiaoshu Guo, Kai Xu, Lan Wang, Linke Ding, Wenwen Li, Xinsheng Zhang, Weiming Zhao, Ningdan Wang, Gaiping Wang, Wenyu Zhao, Ivan Rosas, Guoying Yu
Faculty, Staff and Students Publications
Background: Idiopathic pulmonary fibrosis (IPF) is the result of multiple cycles of epithelial cell injury and fibroblast activation; currently, there is no clear etiology. Increasing evidence suggests that protein metabolism and amino acids play a crucial role in IPF, but the role of D-amino acids is not yet clear. The aim of this study was to identify novel mediators in order to test the hypothesis that D-amino acid oxidase (DAO) plays a significant role in the pathogenesis of IPF.
Methods: We analyzed DAO gene expression in patients with IPF and mice with bleomycin (BLM)-induced lung fibrosis. We performed in vitro …
A Multi-Omics Multi-Environment Prediction In Pulse Crop, Rica Saludares
A Multi-Omics Multi-Environment Prediction In Pulse Crop, Rica Saludares
Plant Sciences
Understanding the genetic bases underlying seed yield and protein, and eventually recombining them in desired genetic backgrounds, continues to be a challenge to pulse crop breeders. Phenotypic selection for seed yield and protein in preliminary yield trials is hindered by the need to phenotype a large number of early-generation lines (>10,000) with limited seeds, resulting to trials with few replications and limited environments. In this study, we evaluated and applied a multi-trait multi-environment (MTME) and a multi-omics prediction framework to address phenotyping bottleneck and the complexities underlying negatively correlated traits, and maximize connectivity among genotypes for predicting performance of …
A Mini Chalk Talk Workshop For Fourth-Year Medical Students: Facilitating The Transition From Student To Resident Educator, Trevor Jamison, Zaven Sargsyan, Uma Ayyala, Stephanie Sherman, Holland Kaplan
A Mini Chalk Talk Workshop For Fourth-Year Medical Students: Facilitating The Transition From Student To Resident Educator, Trevor Jamison, Zaven Sargsyan, Uma Ayyala, Stephanie Sherman, Holland Kaplan
Faculty, Staff and Students Publications
INTRODUCTION: There is increasing recognition that incoming interns benefit from formal training in teaching skills during UME. Many medical schools have capstone courses well suited for teacher-training content. Mini chalk talks (MCTs) are a common clinical teaching modality requiring a variety of teaching skills. We developed a session for our institution's capstone course in which students prepared and delivered MCTs.
METHODS: The voluntary flipped classroom session was offered virtually in 2021 and in person in 2022. Before the session, students reviewed materials on creating effective MCTs and developed and practiced their own MCT. During the 90-minute session, students presented their …
Utilizing Low-Tech Portable Caterpillar Tunnels To Increase Productivity Of Warm-Season Vegetables And Small Fruits, Bijaya Ghimire
Utilizing Low-Tech Portable Caterpillar Tunnels To Increase Productivity Of Warm-Season Vegetables And Small Fruits, Bijaya Ghimire
Plant Sciences
High tunnels and greenhouses effectively extend the growing season and protect crops from adverse environmental conditions. However, production in the less expensive and portable caterpillar tunnel has not been reported. The research aimed to evaluate the phenology, yield and quality of eight paste tomato, eight bell pepper, and two cold-hardy wine grapes grown in the caterpillar tunnel compared to the open field. In 2022, tomato and bell pepper cultivars were severely affected by tomato spotted wilt virus. Caterpillar tunnels extended the growing season and accelerated the key phenological stages of all three species. The tunnel increased the yield and quality …
Targeting Histone Deacetylase In Cardiac Diseases, Jiao Lu, Sichong Qian, Zheng Sun
Targeting Histone Deacetylase In Cardiac Diseases, Jiao Lu, Sichong Qian, Zheng Sun
Faculty, Staff and Students Publications
Histone deacetylases (HDAC) catalyze the removal of acetylation modifications on histones and non-histone proteins, which regulates gene expression and other cellular processes. HDAC inhibitors (HDACi), approved anti-cancer agents, emerge as a potential new therapy for heart diseases. Cardioprotective effects of HDACi are observed in many preclinical animal models of heart diseases. Genetic mouse models have been developed to understand the role of each HDAC in cardiac functions. Some of the findings are controversial. Here, we provide an overview of how HDACi and HDAC impact cardiac functions under physiological or pathological conditions. We focus on in vivo studies of zinc-dependent classical …
High Prevalence Of A-Β+ Ketosis-Prone Diabetes In Children With Type 2 Diabetes And Diabetic Ketoacidosis At Diagnosis: Evidence From The Rare And Atypical Diabetes Network (Radiant), Elizabeth Kubota-Mishra, Xiaofan Huang, Charles G Minard, Marcela Astudillo, Ahmad Refaey, Graciela Montes, Stephanie Sisley, Nalini Ram, William E Winter, Rochelle N Naylor, Ashok Balasubramanyam, Maria J Redondo, Mustafa Tosur, Radiant Study Group
High Prevalence Of A-Β+ Ketosis-Prone Diabetes In Children With Type 2 Diabetes And Diabetic Ketoacidosis At Diagnosis: Evidence From The Rare And Atypical Diabetes Network (Radiant), Elizabeth Kubota-Mishra, Xiaofan Huang, Charles G Minard, Marcela Astudillo, Ahmad Refaey, Graciela Montes, Stephanie Sisley, Nalini Ram, William E Winter, Rochelle N Naylor, Ashok Balasubramanyam, Maria J Redondo, Mustafa Tosur, Radiant Study Group
Faculty, Staff and Students Publications
BACKGROUND:A−β+ ketosis-prone diabetes (KPD) in adults is characterized by presentation with diabetic ketoacidosis (DKA), negative islet autoantibodies, and preserved β-cell function in persons with a phenotype of obesity-associated type 2 diabetes (T2D). The prevalence of KPD has not been evaluated in children. We investigated children with DKA at “T2D” onset and determined the prevalence and characteristics of pediatric A−β+ KPD within this cohort.
METHODS: We reviewed the records of 716 children with T2D at a large academic hospital and compared clinical characteristics of those with and without DKA at onset. In the …
Effects Of Synonymous And Nonsynonymous Cyp51 Mutations On Dmi Resistance In Cercospora Beticola, Isaac Courneya
Effects Of Synonymous And Nonsynonymous Cyp51 Mutations On Dmi Resistance In Cercospora Beticola, Isaac Courneya
Plant Pathology
Cercospora beticola is the most devastating foliar pathogen of sugar beet. This pathogen is primarily managed by the application of fungicides, including demethylation inhibitors (DMIs). Given the broad use of DMIs in managing Cercospora leaf spot, resistance has developed. Recently, five haplotypes of CbCyp51 have been correlated with DMI resistance. To improve our understanding of these haplotypes, this study has evaluated CbCyp51 expression across haplotypes with and without DMI exposure using RT-qPCR. Significant differences were found between haplotypes in control and difenoconazole groups, but the broader implications were unclear. This study also produced mutant C. beticola strains with replaced CbCyp51 …
Genetic Variation In Black Gram And Guar For Phenology, Physiology, Growth, And Yield Under Irrigated And Rainfed Conditions Of Northern Great Plains, Saurabha Koirala
Genetic Variation In Black Gram And Guar For Phenology, Physiology, Growth, And Yield Under Irrigated And Rainfed Conditions Of Northern Great Plains, Saurabha Koirala
Plant Sciences
Field trials were conducted in 2022 and 2023 to evaluate the feasibility of growing black gram (Vigna mungo) and guar (Cyamopsis tetragonoloba) and to identify superior accessions for semiarid conditions of Northern Great Plains, U.S. Significant genetic variability was observed among 21 black gram and 18 guar accessions under rainfed and irrigated conditions. Black gram accession PI425187 yielded the highest grain per plant (8.6 g) under rainfed conditions, while PI377397 and PI377406 performed best under irrigated (6.5 g). Number of pod per plant and seeds per pod were highly correlated with yield per plant. The highest guar yield per plant …
Comparison Of Complication Types In Patients Receiving Vesicant Intravenous Antimicrobials Or Vasopressors Via Midlines And Peripherally Inserted Central Catheters, Bryan Grigg, Nishant Varghese, Christi Knapp, Sabra L Shay, Geraldine Jones, James P Herlihy, Prasad Manian, Bradley Lembcke, Mayar Al Mohajer
Comparison Of Complication Types In Patients Receiving Vesicant Intravenous Antimicrobials Or Vasopressors Via Midlines And Peripherally Inserted Central Catheters, Bryan Grigg, Nishant Varghese, Christi Knapp, Sabra L Shay, Geraldine Jones, James P Herlihy, Prasad Manian, Bradley Lembcke, Mayar Al Mohajer
Faculty, Staff and Students Publications
We assessed adverse events in hospitalized patients receiving selected vesicant antibiotics or vasopressors administered through midline catheters or peripherally inserted central catheters (PICC). The rates of catheter-related bloodstream infections, thrombosis, and overall events were similar across the two groups, while occlusion was higher in the PICC group.