Digital Commons Network^™

Π-Hub: The Proteomic Navigator Of The Human Body, Fuchu He, Ruedi Aebersold, Mark S Baker, Xiuwu Bian, Xiaochen Bo, Daniel W Chan, Cheng Chang, Luonan Chen, Xiangmei Chen, Yu-Ju Chen, Heping Cheng, Ben C Collins, Fernando Corrales, Jürgen Cox, Weinan E, Jennifer E Van Eyk, Jia Fan, Pouya Faridi, Daniel Figeys, George Fu Gao, Wen Gao, Zu-Hua Gao, Keisuke Goda, Wilson Wen Bin Goh, Dongfeng Gu, Changjiang Guo, Tiannan Guo, Yuezhong He, Albert J R Heck, Henning Hermjakob, Tony Hunter, Narayanan Gopalakrishna Iyer, Ying Jiang, Connie R Jimenez, Lokesh Joshi, Neil L Kelleher, Ming Li, Yang Li, Qingsong Lin, Cui Hua Liu, Fan Liu, Guang-Hui Liu, Yansheng Liu, Zhihua Liu, Teck Yew Low, Ben Lu, Matthias Mann, Anming Meng, Robert L Moritz, Edouard Nice, Guang Ning, Gilbert S Omenn, Christopher M Overall, Giuseppe Palmisano, Yaojin Peng, Charles Pineau, Terence Chuen Wai Poon, Anthony W Purcell, Jie Qiao, Roger R Reddel, Phillip J Robinson, Paola Roncada, Chris Sander, Jiahao Sha, Erwei Song, Sanjeeva Srivastava, Aihua Sun, Siu Kwan Sze, Chao Tang, Liujun Tang, Ruijun Tian, Juan Antonio Vizcaíno, Chanjuan Wang, Chen Wang, Xiaowen Wang, Xinxing Wang, Yan Wang, Tobias Weiss, Mathias Wilhelm, Robert Winkler, Bernd Wollscheid, Limsoon Wong, Linhai Xie, Wei Xie, Tao Xu, Tianhao Xu, Liying Yan, Jing Yang, Xiao Yang, John Yates, Tao Yun, Qiwei Zhai, Bing Zhang, Hui Zhang, Lihua Zhang, Lingqiang Zhang, Pingwen Zhang, Yukui Zhang, Yu Zi Zheng, Qing Zhong, Yunping Zhu, Π-Hub Consortium

Faculty, Staff and Students Publications

The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual's body during their lifetime. Understanding the complexities of the proteome in the context of a human organism and its many potential states is a necessary requirement to understanding human biology, but these complexities can neither be predicted from the genome, nor have they been systematically measurable with available technologies. Recent advances in proteomic technology and computational sciences now provide opportunities to investigate the intricate biology of the human body …

External Validation Of The Epic Sepsis Predictive Model In 2 County Emergency Departments, Daniel G Ostermayer, Benjamin Braunheim, Amit M Mehta, Jeremy Ward, Sara Andrabi, Anwar Mohammad Sirajuddin

Faculty, Staff and Student Publications

Objective: To describe the diagnostic characteristics of the proprietary Epic sepsis predictive model best practice advisory (BPA) alert for physicians in the emergency department (ED).

Materials and methods: The Epic Sepsis Predictive Model v1.0 (ESPMv1), a proprietary algorithm, is intended to improve provider alerting of patients with a likelihood of developing sepsis. This retrospective cohort study conducted at 2 county EDs from January 1, 2023 to December 31, 2023 evaluated the predictive characteristics of the ESPMv1 for 145 885 encounters. Sepsis was defined according to the Sepsis-3 definition with the onset of sepsis defined as an increase in 2 points …

A Comparison Of The 2022 Versus 2011 National Institute Of Child Health And Human Development Web-Based Risk Estimator For Bronchopulmonary Dysplasia., Mitch Kinkor, Jake Schneider, Farhath Sulthana, Janelle R. Noel-Macdonnell Phd, Alain Cuna

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To compare the predictive accuracy of the 2022 vs 2011 National Institute of Child Health and Human Development estimator for identifying infants at high risk for bronchopulmonary dysplasia (BPD).

METHODS: We conducted a single-center retrospective study of infants ≤28 weeks' gestation. Demographic and respiratory support data were used to calculate risk for BPD or death by the BPD estimators. Our outcomes of interest included (1) treatment with systemic steroids for BPD and (2) composite outcome of death or highest severity of BPD at 36 weeks' postmenstrual age. We used c-statistics and area under receiver operator characteristic curves (AUC) to …

Impact Of State-Level Family Policies On Female Labor Force Participation And Entrepreneurship, Kathryn Staczek Rudloff

Theses and Dissertations

This dissertation aims to investigate the impact of state-level family policies on women's participation in the labor force in the United States, focusing specifically on the rise of self-employment and solopreneurship among women. The research seeks to answer the following question: "How do family policies at the state level impact participation of American women in the labor force?"

The study utilized a convergent parallel mixed-methods design. A composite index of state level family policies was created to conduct cross-sectional exploratory data analysis of female labor force participation. Additionally, a qualitative phenomenological study of solopreneurs provided a deeper understanding of the …

Synthesis Of Photocleavable Molecules For Neurological Applications, Nishal Madujith Egodawaththa Arachchilage Don

Theses and Dissertations

In recent biomedical research, the precise control of molecular dynamics through light activation has emerged as a powerful tool, particularly in the field of neurobiology. This approach involves the use of photocleavable cages or photoprotective groups (PPGs) that are chemically tethered to biologically active molecules such as neurotransmitters or calcium chelators. These cages remain inert until exposed to specific wavelengths of light, typically in the visible range, triggering the release of the active compound with high spatiotemporal precision.

For neurotransmitter systems, such as glutamate (Glu), which plays a critical role in synaptic transmission and memory formation, researchers have developed novel …

Novel, Ultra-Fast Electrochemical Sensors For The Enhanced Detection Of Neurotransmitters And Toxic Heavy Metals In Aqueous Solutions, Noel Manring

Theses and Dissertations

Neurodegenerative diseases (NDDs) are a growing global health concern, affecting millions of people worldwide. NDDs arise from the progressive loss of neuronal cell function, ultimately leading to cell death. Abnormal levels of neurotransmitters, the chemical messengers in the brain, have also been linked to NDDs. Despite various treatments and medications aimed at alleviating physical and mental symptoms, there is currently no cure or means to halt disease progression. While the exact pathogenesis of NDDs remain poorly understood, cognitive decline is largely attributed to brain volume reduction, particularly in the hippocampus. Clinical studies suggest that environmental factors, such as exposure to …

Adsorption Of Harmful Algal Bloom Toxins Using Biochar, Cadianne Chambers

Theses and Dissertations

Harmful Algal Bloom (HAB) events involve the proliferation of microalgae which discharge lethal toxins into fresh and brackish water bodies due to anthropogenic and climatic activities. Common examples of HABs include causative organisms such as Cyanobacteria, Pyrodinium bahamense and more. These genera are known to release potent toxins including Microcystins, and Saxitoxins, respectively, which can seriously endanger human and marine health. Ingestion of these toxins can result in several health problems, such as nausea, vomiting, gastroenteritis, skin irritation, liver damage, paralysis, and respiratory arrest. The Great Lakes, Gulf of Maine, Florida’s coasts, Lake Erie, and Lake Okeechobee have all been …

Machine Learning Methods For Quantification Of Glacier Variations Through Satellite Imagery, Robert D. Breininger

Theses and Dissertations

Glaciers around the world have experienced a trend of recession within the past century. Quantification of glacier variations using satellite imagery is of great interest due to the importance of glaciers as freshwater resources and as indicators of climate change. The potential methods to quantify glacier variations with increasing complexity include detecting the terminus location, quantifying the glacier surface area, and measuring glacier volume. Although there are methods in literature designed purposefully for glacier area segmentation that have achieved acceptable results, they are often localized to the region where their training data were acquired and further rely on training sets …

Incorporating An Analytical Approach To Ethical Reasoning Into An Ethics Case Conference For Residents, Holland Kaplan, Alyssa Kahl, Jonathan Lim

Center for Medical Ethics and Health Policy Staff Publications

Educating residents to apply ethical principles in clinical practice is critical in achieving standards in professionalism. We implemented biweekly ethics morning report case conferences incorporating a validated analytical tool in medical ethics, the Four-Box Method, from July 2022 to June 2023 in our internal medicine residency program. In 24 ethics morning reports, over 73% of participants reported that the intervention helped them achieve each of three learning objectives in ethics education. Ninety-two percent of cases addressed > 1 ethical issue. Our intervention may be easily integrated into the morning report conference structure as an educational tool in medical ethics across internal …

The Policy And Practice Of Internationalization In The Global-South: African International Students’ Experiences In South Africa During Covid-19, Patience Mukwambo, Faith Mkwananzi, Winter Seshoka

Journal of Comparative & International Higher Education

No abstract provided.

Not-So-Special Solicitude, Katherine Mims Crocker

Faculty Scholarship

In a high-profile case last term about state standing to sue in federal court, Justice Gorsuch deemed it “hard not to wonder why” the majority said “nothing about ‘special solicitude.’” The silence was indeed surprising, for in a landmark decision several years earlier, the Supreme Court had declared that states were “entitled to special solicitude”—presumably meaning some sort of preferential treatment—“in [the] standing analysis.” And since then, commentators had depicted the concept as permitting opportunistic states to wage ideological crusades in courts across the country, especially through administrative-law attacks on federal-government defendants.

But what if “special solicitude” is not so …

Book Review: Transformative Negotiation: Strategies For Everyday Change And Equitable Futures, Peter R. Reilly

Faculty Scholarship

This volume makes an immense contribution to the field of negotiation and to dispute resolution more generally. The book covers a vast amount of ground, effectively connecting theory to practice and harnessing large amounts of research to support its arguments and advice. Perhaps most importantly, this reviewer found reading the book to be—as the title suggests—a transformative experience.

Section 1: Defining Arbitration And Addressing Structural Bias, Nancy A. Welsh

Faculty Scholarship

The Supreme Court’s jurisprudence pursuant to the Federal Arbitration Act (FAA) has successfully encouraged the use of arbitration to resolve disputes of all types, including those arising out of contracts of adhesion. Meanwhile, with one very limited exception, neither Congress nor the Supreme Court has done anything to assure those bound by adhesive contracts that the required arbitration process will be fair, impartial, and consistent with due process principles. The FAA does not even include a definition of arbitration to guide arbitration providers and individual arbitrators. This chapter proposes the addition of a definition of arbitration to the FAA to …

Introduction To Intellectual Property, Innovation And Economic Inequality, Daniel Benoliel, Peter K. Yu

Faculty Scholarship

This chapter provides an introduction to Intellectual Property, Innovation and Economic Inequality. It begins by discussing the problem of economic inequality, including the scale of that problem, types of economic inequality, and extant research on such inequality. The chapter then outlines the structure of this volume, which is divided into three parts: (1) theoretical, empirical, and policy issues; (2) intellectual property and national inequality; and (3) intellectual property and global inequality.

Intellectual Property, Innovation And Economic Inequality, Daniel Benoliel, Peter K. Yu, Francis Gurry, Keun Lee

Faculty Scholarship

While growing disparities in wealth and income are well-documented across the globe, the role of intellectual property rights is often overlooked. This volume brings together leading commentators from around the world to interrogate the interrelationship between intellectual property and economic inequality. Interdisciplinary and globally oriented by design, the book features economists, legal scholars, policy analysts, and other experts. Chapters address the impact of intellectual property rights on economic inequality, the effect of economic inequality on the protection and enforcement of these rights, and the potential use of innovation law and policy to help reduce economic inequality. The volume also tackles …

Reshaping Intellectual Property Scholarship From Within, Peter K. Yu

Faculty Scholarship

Written for the Symposium collecting papers from the Race + IP 23 Conference, this article explores intellectual property scholarship that has been either overlooked or marginalized. Because scholars of color are often outsiders looking in, the article identifies opportunities to reshape intellectual property scholarship from within. Even though the focus of this article was chosen with readers of this Symposium in mind, its insights will be relevant to all scholars.

This article begins by calling on scholars to develop a deeper appreciation of the intrinsic motivations of authors and inventors. It then discusses the oft-overlooked inequalities of creativity and innovation …

Reframing A Data Sharing Mechanism For The Riparian Nations Of Helmand River Basin: Theory Of Planned Behavior Is Revisited, Najibullah Loodin, Gabriel Eckstein, Vijay P. Singh, Rosario Sanchez

Faculty Scholarship

Data and information exchange plays a crucial role in fostering water cooperation between the riparian nations of a shared watercourse. Taking an integrated approach combining Discourse Analysis and Document Analysis, this research aims at elucidating the challenges and the potential opportunities of data and information exchange on the Helmand River, a drought-stricken river basin shared between upstream Afghanistan and downstream Iran. Drawing on the Theory of Planned Behavior (TPB), we offer nuanced perspectives on the data exchange model developed by Wehn. We argue that there are other underlying and essential elements that hinder the meaningful engagement of the riparian nations …

The Impact Of Elder Abuse Training On Subacute Health Providers And Older Adults: Study Protocol For A Randomized Control Trial, Marina G. Cavuoto, Simona Markusevska, Catriona Stevens, Patricia Reyes, Gianna Renshaw, Micah D.J. Peters, Briony Dow, Peter Feldman, Andrew Gilbert, Elizabeth Manias, Duncan Mortimer, Joanne Enticott, Claudia Cooper, Josefine Antoniades, Brenda Appleton, Sigrid Nakrem, Meghan O’Brien, Joan Ostaszkiewicz, Marion Eckert, Cheryl Durston, Bianca Brijnath

Research outputs 2022 to 2026

Background: Elder abuse often goes unreported and undetected. Older people may be ashamed, fearful, or otherwise reticent to disclose abuse, and many health providers are not confident in asking about it. In the No More Shame study, we will evaluate a co-designed, multi-component intervention that aims to improve health providers’ recognition, response, and referral of elder abuse. Methods: This is a single-blinded, pragmatic, cluster randomised controlled trial. Ten subacute hospital sites (i.e. clusters) across Australia will be allocated 1:1, stratified by state to a multi-component intervention comprising a training programme for health providers, implementation of a screening tool and use …

A Hybrid Approach Of Vision Transformers And Cnns For Detection Of Ulcerative Colitis, Syed Abdullah Shah, Imran Taj, Syed Muhammad Usman, Syed Nehal Hassan Shah, Ali Shariq Imran, Shehzad Khalid

All Works

Ulcerative Colitis is an Inflammatory Bowel disease caused by a variety of factors that lead to a serious impact on the quality of life of the patients if left untreated. Due to complexities in the identification procedures of this disease, the treatment timeline and quality can be severely affected, leading to further consequences for the sufferer. The difficulties in identification are due to high patients to healthcare professionals ratio. Researchers have proposed variety of machine/deep learning methods for automated detection of ulcerative colitis, however, several challenges exists including class imbalance problem, comprehensive feature extraction and accurate classification. We propose a …

Recent Advances In Transition Metal-Based Photocatalytic Heterojunctions For Algal Inhibition And Water Disinfection: A Review, Yaksha Verma, Gaurav Sharma, Jibran Iqbal, Mu Naushad, Chin Wei Lai, Amit Kumar, Pooja Dhiman, Ackmez Mudhoo

All Works

Sustainable energy production and effective water pollution control are critical global priorities. Harmful algal blooms (HABs) and waterborne pathogens pose significant threats to water quality and public health, necessitating efficient and eco-friendly treatment methods. Transition metal-based photocatalytic heterojunctions offer promising solutions by leveraging the unique properties of transition metals to enhance photocatalytic efficiency. This review examines recent advances in these heterojunctions employed for algal inhibition and water disinfection, discussing various heterojunction type (including conventional, p-n, Z-scheme, S-scheme, and Schottky heterojunctions), and their synthesis methods. We elucidate the mechanisms involved, highlighting improved electron transfer, reduced recombination rates, and broadened light absorption. …

Human Vs. Ai Counseling: College Students' Perspectives, Mohammad Amin Kuhail, Nazik Alturki, Justin Thomas, Amal K. Alkhalifa

All Works

Transitioning to college life while navigating the complexities of emerging adulthood can be stressful. In some instances, it may even lead to the onset of mental health problems or the exacerbation of existing issues. While therapeutic resources are typically available in tertiary educational contexts, social stigma may lead to service underutilization. Additionally, high student-to-therapist ratios can create bottlenecks to access when such services are sought. Offering an adjunct to traditional campus counseling services, AI chatbots can potentially address such issues. Chatbots can provide flexible, accessible, anonymous, and cost-effective first-line support, improving access and extending traditional treatment methodologies. This study evaluates …

Cognitive Behavioral Therapy-Enhanced Through Videoconferencing For Night Eating Syndrome, Binge-Eating Disorder And Comorbid Insomnia: A Case Report, Bernou Melisse, Teresa Arora

All Works

Background: Both night-eating syndrome and binge-eating disorder are characterized by episodes of excessive food consumption, significant distress, and functional impairment related to maladaptive eating behaviors. Both types of eating disorders are associated with poorer sleep quality. Cognitive behavioral therapy has demonstrated good outcomes for binge-eating disorder; however, it is unknown if it is effective for night-eating syndrome and comorbid insomnia. Case presentation: The current paper presents a case report of a Dutch woman in her 40’s receiving cognitive behavioral therapy-enhanced for night-eating syndrome, as well as binge-eating disorder. However, to tailor the intervention to her specific needs, throughout the course …

United States Environmental Protection Agency Response To The Ofiice Of Science And Technology Policy Memo, 2022: Public Access Plan (December 2024)

Copyright, Fair Use, Scholarly Communication, etc.

EPA response to OSTP memo, 2022: Public Access Plan (December 2024)

United States Department Of Defense Response To The Office Of Science And Technology Policy Memo, 2022: Public Access Plan (December 2024)

Copyright, Fair Use, Scholarly Communication, etc.

DOD response to OSTP memo, 2022: Public Access Plan (December 2024)

Acf Response To Ostp Memo, 2022: Public Access Plan (December 2024)

Copyright, Fair Use, Scholarly Communication, etc.

ACF response to OSTP memo, 2022: Public Access Plan (December 2024)

General Sport Skills Performance Following The Combined Use Of Accentuated Eccentric Loading And Cluster Sets During A Strength-Endurance Training Phase, David Nelson

Electronic Theses and Dissertations

The purpose of this study aimed to evaluate the efficacy of resistance training with accentuated eccentric loading (AEL) and cluster sets (CS) versus traditional resistance training (TRAD) on general sports skills and power performance in recreationally trained individuals. Seventeen subjects (11 males, 6 females; mean age 23.2 ± 4.1 years; body mass 81.3 ± 22.2 kg; height 172.1 ± 10.0 cm; relative 1 RM back squat 1.5 ± 0.3) were randomly assigned to AEL (n = 9) or TRAD (n = 8) groups. After an initial familiarization and baseline testing, both groups underwent a four-week strength-endurance training regimen. The AEL …

Graduation Rates Of Students With Disabilities At A Participating Southern University, Kelly Mitchell

Electronic Theses and Dissertations

The purpose of this non-experimental, correlational quantitative study was to compare the graduation rates of first-time, full-time students with disabilities to those of first-time, full-time students in the general population at the participating university. The sample used for analysis was full-time, first-time students entering between 2015 and 2020. Using archival data from the Disability Services database and the University's Banner system, four- and six-year graduation rates were compared. The original data set consisted of 22,070 students in the starting focus cohorts. After removing entering transfer students and students who enrolled in less than 15 credits for their entering semester, 8,337 …

Self-Rated Interprofessionalism Between Allied Health Professionals, Courtney Andrews

Electronic Theses and Dissertations

Preventable deaths due to medical errors are a significant cause of death in the United States. Decreased communication and collaboration has been cited as a potential reason for these preventable medical errors. Interprofessional practice (IPP) is a service delivery method where medical professionals from different disciplines intentionally work together in order to provide collaborated and collective care for patients. Interprofessional education (IPE) training programs are becoming more common in healthcare education, and have been cited as one way to improve IPP among healthcare providers. However, gaps exist in the literature regarding how to best structure and implement these programs so …

Community College Student Success During Covid-19 Pandemic Based On Class Modality, Rebecca Aslinger

Electronic Theses and Dissertations

The purpose of this non-experimental, quantitative, comparative study was to determine whether there were significant differences in Introduction to Education grades as measured by GPA among community college students between 2018-23 with the change of class modality due to the Covid-19 pandemic.

This study examined differences in Introduction to Education grades as measured by GPA at three community colleges from 2018-23. Archival data were used for this study. The population for this study consisted of all students enrolled in the Introduction to Education course at three institutions. Both in-person and online classes were examined during the time before, during, and …

Quantifying Brain Development In The Healthy Brain And Child Development (Hbcd) Study: The Magnetic Resonance Imaging And Spectroscopy Protocol, Douglas C Dean 3rd, Chad M Sylvester, Michael P Harms, Christopher D Smyser, Et Al.

2020-Current year OA Pubs

The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The acquisition of multimodal magnetic resonance-based brain development data is central to the study's core protocol. However, application of Magnetic Resonance Imaging (MRI) methods in this population is complicated by technical challenges and difficulties of imaging in early life. Overcoming these challenges requires an innovative and harmonized approach, combining age-appropriate acquisition protocols together with specialized pediatric neuroimaging strategies. The HBCD MRI Working Group aimed to establish a core acquisition …