Digital Commons Network^™

Modelling Tinnitus Functional Index Reduction Using Supervised Machine Learning Algorithms, Edmund F. Agyemang

School of Mathematical & Statistical Sciences Faculty Publications

This study aims to model the reduction in the Tinnitus Functional Index (TFI) utilizing supervised machine learning algorithms, focusing primarily on Ordinary Least Squares (OLS), K-Nearest Neighbor (KNN), Ridge, and Lasso regressions. Our analysis highlighted Group, ISI, and SWLS as significant predictors of TFI reduction, identified through the best subset selection and confirmed by both forward and backward selection criteria in the OLS regression. Notably, the shrinkage methods, Ridge and Lasso regressions, demonstrated superior performance compared to OLS and KNN, with the Ridge regression presenting the smallest test mean square error (MSE) of 318.30. This finding establishes the Ridge regression …

Targeting The Glutamine-Arginine-Proline Metabolism Axis In Cancer, Di Wang, Jiang-Jie Duan, Yu-Feng Guo, Jun-Jie Chen, Tian-Qing Chen, Jun Wang, Shi-Cang Yu

Faculty, Staff and Student Publications

Metabolic abnormalities are an important feature of tumours. The glutamine-arginine-proline axis is an important node of cancer metabolism and plays a major role in amino acid metabolism. This axis also acts as a scaffold for the synthesis of other nonessential amino acids and essential metabolites. In this paper, we briefly review (1) the glutamine addiction exhibited by tumour cells with accelerated glutamine transport and metabolism; (2) the methods regulating extracellular glutamine entry, intracellular glutamine synthesis and the fate of intracellular glutamine; (3) the glutamine, proline and arginine metabolic pathways and their interaction; and (4) the research progress in tumour therapy …

Private Landowner Interest In Prescribed Fire In California: Findings From Workshops In The Sierra Nevada, Kate M. Wilkin, Amanda M. Stasiewicz, Susan D. Kocher

Faculty Research, Scholarly, and Creative Activity

Background: Globally, prescribed fire political interest and practice has been rekindled following recent devastating wildfire seasons. This phenomenon was especially acute in areas with dual wildfire and forest health crises, like California. Previous research has investigated prescribed fire on public lands or on private lands in other regions, but little is known about prescribed fire practice or interest on private lands in California. Therefore, we sought to understand private land managers’ perceptions of prescribed fire compared to other land management techniques, treatment pathways, motivations, and barriers to complete these treatments in California. Results: Before workshops on prescribed fire for private …

Impact Of Prenatal Genomics On Clinical Genetics Practice, Roni Zemet, Ignatia B Van Den Veyver

Duncan NRI Faculty and Staff Publications

Genetic testing for prenatal diagnosis in the pre-genomic era primarily focused on detecting common fetal aneuploidies, using methods that combine maternal factors and imaging findings. The genomic era, ushered in by the emergence of new technologies like chromosomal microarray analysis and next-generation sequencing, has transformed prenatal diagnosis. These new tools enable screening and testing for a broad spectrum of genetic conditions, from chromosomal to monogenic disorders, and significantly enhance diagnostic precision and efficacy. This chapter reviews the transition from traditional karyotyping to comprehensive sequencing-based genomic analyses. We discuss both the clinical utility and the challenges of integrating prenatal exome and …

Developing An Roi Assessment Model For Employee Development Programs Implemented By California Transit Agencies, Tyler Reeb, Susan Gallagher

Mineta Transportation Institute

The objective of this research is to determine the extent to which transit agencies in California are implementing Return on Investment (ROI) assessments or otherwise evaluating the value and effectiveness of the employee development programs they administer, what cost and performance data they collect and track, and what resources or support are needed to support ROI assessment efforts. Transit agencies will necessarily incur expenses in efforts to improve the recruitment, retention, and morale of employees, but will struggle to solicit adequate funding unless they are able to demonstrate the value of such efforts to a broader audience. Thus, developing and …

Right Turn On Red: Energy-Saving Measure Or Unsafe Maneuver?, Bruce Appleyard, Anurag Pande, Joseph Gibbons, Shams Tanvir, Megan Honey, Nell Ahangarfabrik, Mario Carbajal, Madison Swayne

Mineta Transportation Institute

There is a growing interest in prohibiting right turn on red (RTOR) policies in the name of pedestrian and bicycle safety but there is not enough research on the subject to help agencies make informed decisions. When Congress passed the Energy Policy and Conservation Act of 1975, they included a provision requiring states to permit right turns on red lights as an energy-saving measure to receive federal assistance for mandated conservation programs. Since 1980, all states have permitted right turns on red as a general rule. More research is needed to help guide state policies that can support jurisdictions in …

An Assessment Of The Viva Callesj Event In San Jose, Richard Kos, Adam Cohen

Mineta Transportation Institute

This report evaluates the Viva CalleSJ event held in San Jose, California, on September 8, 2024. As a celebrated open-streets initiative, Viva CalleSJ temporarily transformed six miles of city streets into car-free zones to encourage active transportation, foster community engagement, and support local businesses. This assessment employed a mixed-methods approach, including participant surveys, interviews with stakeholders, and observational analysis. Key findings highlighted the event’s success in attracting a diverse audience, promoting physical activity, and driving economic benefits. Over 50% of attendees arrived by bicycle, and 77.7% planned to spend money at the event, averaging $54.23 per participant. Community-building impacts were …

Zero-Emission Buses In The Us: Understanding And Addressing Market And Policy Challenges, Leah Foecke, Zachary Karson, Thomas Tiberghien

Mineta Transportation Institute

As the US public transportation sector accelerates its shift from fossil fuels to zero-emission alternatives, transit agencies and transit bus manufacturers alike face significant uncertainty and instability. This report provides policymakers with updated insights into the US transit bus market, focusing on key industry dynamics, financial challenges with zero-emission bus (ZEB) acquisition, technological obstacles in deployment, and regulatory issues. The research relies on interviews with stakeholders, a detailed review of existing literature, and an analysis of US public transit data. Key findings reveal ongoing challenges related to costs, supply, reliability, and workforce development, all of which hinder the adoption of …

Morphological Changes Of Liver Among Post-Fontan Surgery Patients, Varatharajan Nainamalai, Håvard Bjørke Jenssen, Khadiza Tun Suha, Mostafa Rezaeitaleshmahalleh, Min Wang, Sarah Khan, Marcus Haw, Jingfeng Jiang, Joseph Vettukattil

Michigan Tech Publications

Purpose: Liver screening and longitudinal study of Fontan Associated Liver Diseases (FALD) is essential to identifying hepatomegaly and how hepatomegaly relates to various stages of liver fibrosis. In this study, we investigated longitudinal liver shape changes and liver stiffness in a cohort of patients with Fontan Associated Liver Disease. Methods: We used 170 image volumes of 40 Fontan stage 3 completion patients. We also used 65 computed tomography images of healthy individuals from three datasets for comparison. Thirteen radiomic shape features of Fontan patients and individuals with a healthy liver were extracted and analyzed longitudinally. We studied correlations among features, …

Coastal Empire Economic Monitor, 4th Quarter, 2024, Georgia Southern University Center For Business Analytics And Economic Research

Coastal Empire Economic Monitor

• Bounce-back From Hurricanes

• Savannah Metro Economy Back on Track

• U.S. Economic Growth Continues, 2025 Looks Murkey

• U.S. Economy First Quarter Preview

• Forecasting Index Falls

Increasing Safety Net Antibiotic Prescriptions For Acute Otitis Media In Urgent Care Clinics., Jennifer Mckinsey, Brian R. Lee, Donna Wyly, Holly Austin, Dinah Dosdos, Emily Murdock, Aimy Patel, Rana El Feghaly, Amanda Nedved

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To evaluate the effectiveness of multifaceted interventions in improving the use of safety net antibiotic prescriptions (SNAPs) for nonsevere acute otitis media (AOM).

STUDY DESIGN: We used quality improvement methodology to develop iterative Plan-Do-Study-Act cycles to increase the use of SNAP for nonsevere AOM in 3 pediatric urgent care centers from October 2021 to June 2023. Interventions included education, electronic health record changes, audits and feedback, and a time-limited financial incentive. We measured the percentage of eligible patients with AOM offered SNAP as our primary outcome. Our secondary outcome measured the percentage of SNAPs accepted. Our process measure evaluated …

Comparison Of Methods For Amphetamine Enantiomer Analysis Using Hplc And 1h-Nmr, Martin Mai

Student Theses

A molecule is chiral if it cannot be superimposed on its mirror image. Chiral drugs exist as these mirror image enantiomers, which can differ in their pharmacological effects. When a drug’s active molecule exists as a pair of enantiomers, the relative ratio of each enantiomer in the final product can provide information about the source of production for this drug, i.e., whether the drug was legally or illegally produced. However, typical detection methods may not differentiate between enantiomers of a chiral molecule. This thesis study compares three different methods for enantiomer detection of amphetamine, which is a drug often prescribed …

Traumatic Chylothorax Following Blunt Thoracic Trauma, Christopher Harvey, Hannah Shin, Sarah Martin, Lindsey Perea

PCOM Scholarly Works

BACKGROUND: Chylothorax occurs when chyle from the thoracic duct leaks into the pleural space. While majority of cases are iatrogenic, traumatic chylothorax can occur when rib or vertebral fractures disrupt the thoracic duct. These occurrences are exceedingly rare, particularly following blunt traumatic insult.

METHODS: We performed a retrospective review of a case of chylothorax following blunt trauma. Data was extracted from the electronic medical record.

CASE: A 60-year-old female presented to the trauma bay after a motor vehicle crash as a restrained driver with bilateral chest pain. Of note, patient had three left rib fractures from fall five days prior. …

Using Nano-Ities For Detection Of Metal Ions In Complex Aqueous Solutions, Mohammed Muzammil Nishar Ahmed

Theses and Dissertations

Recent urbanization has induced a rapid increase in heavy metal exposure to humans. The exploitation of heavy metals for economic gains coupled with poor and economically infeasible recycling methods have led to poor management of heavy metal wastes, which has opened up several pathways for heavy metals to enter the human body. Such heavy metals target many vital organs, but the early symptoms are common and difficult to diagnose. Severe symptoms appear in later stages and are very expensive to treat and the damage caused to the health are not typically reversable in such later stages. To counter this issue, …

Ecological And Pathological Applications Of The Heat Shock Response, Taylor Rae Stanley

Theses and Dissertations

The heat shock response (HSR) is a cytoprotective stress response pathway that regulates cellular proteostasis. The HSR is an evolutionarily conserved pathway that is essential for normal cellular functioning. Here, we explore the broad ecological and pathological impacts of the HSR. In an ecological context, we perform gene level analysis of the transcriptomes of two closely related sunfish. We found that the more invasive bluegill sunfish has gene expansions in two HSR gene families, the HSP70 family and the HSP90 family compared to the redear sunfish. These gene expansions were also observed in several other teleost fish species and were …

Tac-It An Affective Computing User Interface Design, Andrew Biron

Theses and Dissertations

TAC-IT affective computing user-interface design is an independent computer peripheral that is a tool to be utilized to obtain a user’s self-reported emotional state in real-time. Doctor Rosalind Picard first coined and used the term affective computing in her paper Affective Computing [Picard, R. (1995)]. Affective Computing is defined as the study and development of systems and devices that can recognize, interpret, process, and simulate human affects. It is an interdisciplinary field spanning computer science, psychology, and cognitive science. Since that time, areas of research have expanded exponentially, and areas of interest include how to trigger emotions in a test …

Investigation Of Reproductive Inhibition During Chronic Heat Stress In C. Elegans, Macy Makenna Nielander

Theses and Dissertations

Nearly all organisms experience heterogeneity in environmental conditions that can negatively impact fitness. A common adaptive strategy to reduce the impact of this stress is called facultative diapause, where development and reproduction are temporarily arrested to promote survival. Facultative diapause is characterized by three major criteria, the arrest must be (i) induced by an unfavorable environmental condition, (ii) reversible, and (iii) driven by genetically regulated mechanisms. The aim of this thesis was to determine whether chronic heat-induced inhibition of egg laying in Caenorhabditis elegans represents a novel form of facultative diapause. It was found that the inhibition of egg-laying is …

Immediate Effect Of Local Vibration On Motor Unit Firing Behavior And Muscle Strength In Healthy Young Adult Males, Yuichi Nishikawa, Aleš Holobar, Kohei Watanabe, Toshihiko Komatsuzaki, Takanori Chihara, Jiro Sakamoto, Takashi Kawagoe, Hidetaka Nagayasu, Kyoko Mori, Kenji Kawano, Noriaki Maeda, Shinobu Tanaka, Allison S. Hyngstrom

Physical Therapy Faculty Research and Publications

Purpose

The aim of this study was to examine the effect of vibration on motor unit (MU) firing behavior and physical performance of antagonist muscles in healthy young adult males.

Methods

Fourteen males (age = 24.3 ± 3.6 years) were included in this study. There were two conditions, one in which participants received 80 Hz vibration in the distal tendon of the hamstring for 30 s and the control condition (no vibration). High-density surface electromyography (HD-SEMG) signals and maximal voluntary contraction (MVC) of knee extensor muscles were evaluated before and after the respective conditions and recorded from the vastus lateralis …

Assessing Prescribing Trends And Pharmacist Role In Optimization Of Iv Iron Sucrose, Katherine Fernandez, Erika Dittmar, Heidi Clarke, Stephanie Palma, Jonathan Kline

Nursing & Health Sciences Research Journal

Background: Iron deficiency can occur in the presence or absence of anemia and is defined as ferritin less than 15–30 μg/L or transferrin saturation less than 20% per the American Society of Hematology guidelines. Intravenous (IV) iron is used to treat iron deficiency when oral iron supplements are ineffective or not tolerated due to gastrointestinal issues or inability to take medications orally. Intravenous iron allows for more rapid replenishment of iron stores, especially in cases where absorption is compromised. There is no significant difference in efficacy between IV iron formulations, making cost-effectiveness a crucial consideration in product selection. Our health …

Evaluation Of A Non-Metallic Dual-Port Expander For Intensity Modulated Proton Therapy, Kristen Mcconnell, Zachary Fellows, James Kraus, Mauricio Acosta, Joseph Panoff, Eduardo Pons, Alonso Gutierrez, Andrew Wroe

All Publications

Purpose: To provide a methodology for characterization of the technical properties of a newly developed non-metallic tissue expander for intensity modulated proton therapy.

Methods: Three tissue expanders (AlloX2-Pro: plastic-dual port, AlloX2: metal-dual port, and Dermaspan: metal-single port) were deconstructed, CT-scanned, and modeled in RayStation12A. A 165 MeV single spot was used to create RayStation dose planes, and the integrated depth dose profiles were calculated and the DR90 extracted to predict water equivalent thickness (WET). These predictions were compared to measurements taken with an IBA Giraffe MLIC. Native, water, and fully modelled overrides were compared for the AlloX2 Pro to quantify …

A Comparison Of The 2022 Versus 2011 National Institute Of Child Health And Human Development Web-Based Risk Estimator For Bronchopulmonary Dysplasia, Mitchell Kinkor, Jake Schneider, Farhath Sulthana, Janelle Noel-Macdonnell, Alain Cuna

Student Publications

Objective

To compare the predictive accuracy of the 2022 vs 2011 National Institute of Child Health and Human Development estimator for identifying infants at high risk for bronchopulmonary dysplasia (BPD).

Methods

We conducted a single-center retrospective study of infants ≤28 weeks' gestation. Demographic and respiratory support data were used to calculate risk for BPD or death by the BPD estimators. Our outcomes of interest included (1) treatment with systemic steroids for BPD and (2) composite outcome of death or highest severity of BPD at 36 weeks’ postmenstrual age. We used c-statistics and area under receiver operator characteristic curves (AUC) to …

Ectopic Dental Canal: A Case Report Highlighting A Unique Bifid Mandibular Canal Variant, Kevin W. Yu, Manal Hamdan, Stephanie J. Sidow

School of Dentistry Faculty Research and Publications

Bifid mandibular canals are common anatomical findings with variations based on direction and location of branching, which carry significant clinical implications for endodontic and surgical dental procedures. This case report describes a previously unreported ectopic dental canal that branches off the superior border of the mandibular canal, enters the apex of a mandibular second molar, traverses through the root, anastomoses with the root canal system, and subsequently exits through the lingual aspect of the root. The anastomosis of this ectopic dental canal with the mesial lingual canal led to significant bleeding during rotary instrumentation. This unique anatomical variation demonstrates the …

Mesoporous Silica Administration As A New Strategy In The Management Of Warfarin Toxicity: An In-Vitro And In-Vivo Study, Fatemeh Farjadian, Fatemeh Parsi, Reza Heidari, Khatereh Zarkesh, Hamid Reza Mohammadi, Soliman Mohammadi-Samani, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Purpose:

Warfarin is one of the most widely used anticoagulants that functions by inhibiting vitamin K epoxide reductase. Warfarin overdose, whether intentional or unintentional, can cause life-threatening bleeding. Here, we present a novel warfarin adsorbent based on mesoporous silica that could serve as an antidote to warfarin toxicity.

Methods:

Amino-functionalized mesoporous silica (MS-NH2) was synthesized based on the co-condensation method through a soft template technique followed by template removal. The prepared structure and functional group were studied by Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) checked the morphology. The …

Families’ Experiences Accessing Care After Genomic Sequencing In The Pediatric Cancer Context: “It’S Just Been A Big Juggle”, Blake Vuocolo, Amanda M Gutierrez, Jill O Robinson, Alva M Recinos, Lauren R Desrosiers, Mary A Majumder, Juan Carlos Bernini, Jonathan Gill, Timothy Griffin, Gail E Tomlinson, Kelly Vallance, Amy L Mcguire, D Williams Parsons, Sharon E Plon, Sarah Scollon

Faculty, Staff and Students Publications

Access to genomic sequencing (GS) and resulting recommendations have not been well described in pediatric oncology. GS results may provide a cancer predisposition syndrome (CPS) diagnosis that warrants screening and specialist visits beyond cancer treatment, including testing or surveillance for family members. The Texas KidsCanSeq (KCS) Study evaluated implementation of GS in a diverse pediatric oncology population. We conducted semi-structured interviews (n = 20) to explore experiences of KCS patients' families around learning about a CPS diagnosis and following up on recommended care. We used qualitative content analysis to develop themes and subthemes across families' descriptions of their experiences accessing …

Metacognition Across The Curriculum, Amber Young-Brice

College of Nursing Faculty Research and Publications

For nursing students to succeed, they must reflect on their learning, think critically, and develop skills to adequately retrieve pertinent information relevant to patient care (Waryold et al., 2021). We often hear, “Just tell me what I need to know,” and witness students struggling to think deeply, reflect on if they are making the right decisions for the right reasons, and gain self-awareness of what they know and what they do not know. What can we do about this?

Intensive Postpartum Antihypertensive Treatment (Ipat) And Healthy Lifestyle Education: Study Protocol For A Pilot Randomized Controlled Trial For Patients With Hypertensive Disorders Of Pregnancy, Anna Palatnik, Nadine Sunji, Zaira Peterson, Jennifer M. Ohlendorf, Amy Y. Pan, Jacquelyn Kulinski

College of Nursing Faculty Research and Publications

Background

Hypertensive disorders of pregnancy (HDP) complicate about 10% of pregnancies and lead to postpartum hospital readmissions and cardiovascular complications. Following HDP, vascular dysfunction could persist and accelerate the trajectory of cardiovascular disease risk. The benefits of intensive blood pressure (BP) control following HDP have not been adequately investigated. Therefore, no standard guidelines exist to guide the management of mild-to-moderate hypertension in the postpartum period, leading to a wide variation in clinical practice. The present study will investigate the effect of intensive BP control and healthy lifestyle education on maternal cardiovascular health (CVH) and vascular function following HDP.

Methods

The …

The Role Of Leadership In Embedding Social Emotional Learning For Systematic Change In Chicago’S Elementary Schools, Alexandra K. Dakessian

Dissertations

Students within Chicago Public Schools (CPS) are experiencing an unprecedented level of trauma and displaying an immense need for social emotional support. This work evaluated the implementation of social-emotional learning (SEL) programming in CPS by exploring the roles of stakeholders in implementing SEL support in the district and in individual schools, identifying the barriers to effective implementation, and recommending measures to enhance SEL practices at the local and state levels. Data for the study were collected in 2023 and 2024 through interviews with school leaders and revealed both the progress in SEL integration as well as the significant disparities that …

The Effectiveness Of Mbsr On The Occupational Stress Of Correctional Officers, Nikolas Kerr

Dissertations

This dissertation looks at the negative effects of the work environment and other factors related to correctional officers lived experience. The intervention concentrates on the effect of mindfulness-based stress reduction on the occupational stress of correctional officers. Correctional officers have always dealt with difficult work conditions, but over the last 30 years the increase in the number of incarcerated people, the lack of retention among correctional officers, and the proliferation of inmates with complex mental health issues and gang affiliations have all created a much more complex and dangerous work environment. Combine this with the new understanding of the effects …

Protective Play: The Impact Of A Before-School Play Program On Sixth-Grade Students’ Social-Emotional Well-Being, Luleta Dardovski

Dissertations

This mixed-methods study explored the impact of a daily thirty-minute before-school play program on sixth-grade students' social and emotional well-being, using the five CASEL core competencies and S.A.F.E. (Sequenced, Active, Focused, Explicit) framework as guiding principles. The study addressed the central research question: How does unstructured play before school influence students’ social-emotional learning (SEL) skills and well-being? Data was collected through student surveys, interviews with teachers, and observations to explore how play fosters SEL skill development. Play was found to offer an authentic environment for sixth grade students to actively practice SEL skills, fostering benefits in self-esteem, social connectedness, emotional …

Incorporating Meditation, Yoga, And Reiki Interventions To Reduce Stress, Anxiety, And Mood Symptoms Among The College Population, Kelly Wills

Dissertations

The purpose of this clinical research project is to examine the efficacy of mindfulness techniques and alternative therapeutic practices, specifically, meditation, yoga, and Reiki, in decreasing symptoms of anxiety among college students. The increasing prevalence of anxiety disorders among the college population warrants the need for identifying effective interventions for enhancing mental health outcomes. This review integrates findings from published studies that focus on the impact of these practices on anxiety-related symptoms within college settings. Reviewing these studies reveals consistent evidence to support the effectiveness of mindfulness meditation as it relates to anxiety reduction as well as improvements in emotional …