Digital Commons Network^™

Bst2 Facilitates Activation Of Hematopoietic Stem Cells Through Erk Signaling, Marcus A Florez, Apoorva Thatavarty, Duy T Le, Holly A Hill, Youngjae Jeong, Brian M Ho, Pawel Kus, Trisha K Wathan, Bailee N Kain, Shixia Huang, Dongsu Park, Katherine Y King

Faculty, Staff and Students Publications

The proinflammatory cytokine interferon-gamma (IFNγ) is upregulated in a variety of infections and contributes to bone marrow failure through hematopoietic stem cell (HSC) activation and subsequent exhaustion. The cell surface protein, bone marrow stromal antigen 2 (BST2), is a key mediator of this process, as it is induced upon interferon stimulation and required for interferon-dependent HSC activation. To identify the mechanism by which BST2 promotes interferon-dependent HSC activation, we evaluated its role in niche localization, immune cell function, lipid raft formation, and intracellular signaling. Our studies indicated that knock out (KO) of BST2 in a murine model does not disrupt …

Piloting A Novel Computational Framework For Identifying Prosthesis-Specific Contributions To Gait Deviations, Jacques Ezechiel N'Guessan, Muhammad Hassaan Ahmed, Matthew Leineweber, Sachin Goyal

Faculty Research, Scholarly, and Creative Activity

This paper introduces a novel computational framework for evaluating above-knee prostheses, addressing a major challenge in gait deviation studies: distinguishing between prosthesis-specific and patient-specific contributions to gait deviations. This innovative approach utilizes three separate computational models to quantify the changes in gait dynamics necessary to achieve a set of ideal gait kinematics across different prosthesis designs. The pilot study presented here employs a simple two-dimensional swing-phase model to conceptually demonstrate how the outcomes of this three-model framework can assess the extent to which prosthesis design impacts a user's ability to replicate the dynamics of able-bodied gait. Furthermore, this framework offers …

Shared Genetic Architecture Of Non-Viral Cirrhosis With Several Pleiotropic Traits: A Nested Case-Control Study In The Uk Biobank, Jinyoung Byun, Hyun-Seok Kim, Younghun Han, Aaron P Thrift, Sabrina M Lin, Xiangjun Xiao, Hyeyeun Lim, Goo Jun, Stacia M Desantis, Hashem B El-Serag, Fasiha Kanwal, Christopher I Amos

Faculty, Staff and Students Publications

Background & aims: Cirrhosis is a leading cause of liver-related mortality and a multifactorial disease. To date, the complex genetic architecture of non-viral cirrhosis has not been fully explored. Cross-trait genetic correlations can elucidate the common genetic etiology of genetically correlated phenotypes. This study aims to identify polygenic and pleiotropic traits associated with cirrhosis using the linkage disequilibrium score regression analysis.

Methods: We conducted genome-wide association analysis of 9,622,842 imputed SNPs on 3,368 non-viral cirrhosis cases and 258,258 controls, and cross-trait analysis between non-viral cirrhosis and various polygenic and pleiotropic traits using the UK Biobank cohort study. We further performed …

Proteomic Analysis Uncovers Multiprotein Signatures Associated With Early Diabetic Kidney Disease In Youth With Type 2 Diabetes Mellitus, Laura Pyle, Ye Ji Choi, Phoom Narongkiatikhun, Kumar Sharma, Sushrut Waikar, Anita Layton, Kalie L Tommerdahl, Ian De Boer, Timothy Vigers, Robert G Nelson, Jane Lynch, Frank Brosius, Pierre J Saulnier, Jesse A Goodrich, Jeanie B Tryggestad, Elvira Isganaitis, Fida Bacha, Kristen J Nadeau, Daniel Van Raalte, Matthias Kretzler, Hiddo Heerspink, Petter Bjornstad

Faculty, Staff and Students Publications

Background: The onset of diabetic kidney disease (DKD) in youth with type 2 diabetes (T2D) mellitus often occurs early, leading to complications in young adulthood. Risk biomarkers associated with the early onset of DKD are urgently needed in youth with T2D.

Methods: We conducted an in-depth analysis of 6596 proteins (SomaScan 7K) in 374 baseline plasma samples from the Treatment Options for Type 2 Diabetes in Adolescents and Youth study to identify multiprotein signatures associated with the onset of albuminuria (urine albumin-to-creatinine ratio ≥30 mg/g), a rapid decline in eGFR (annual eGFR decline >3 ml/min per 1.73 m2 and/or ≥3.3% …

Late Gadolinium Enhancement And Anomalous Coronary Aortic Origin In A Large Paediatric Cohort, Shagun Sachdeva, Lauren Ferrino, Tam T Doan, Dana Reaves-O'Neal, Stephen Dolgner, Alberto Cipriani, Cristina Basso, Massimo A Padalino, Domenico Corrado, Prakash Masand, Silvana Molossi

Faculty, Staff and Students Publications

No abstract provided.

Π-Hub: The Proteomic Navigator Of The Human Body, Fuchu He, Ruedi Aebersold, Mark S Baker, Xiuwu Bian, Xiaochen Bo, Daniel W Chan, Cheng Chang, Luonan Chen, Xiangmei Chen, Yu-Ju Chen, Heping Cheng, Ben C Collins, Fernando Corrales, Jürgen Cox, Weinan E, Jennifer E Van Eyk, Jia Fan, Pouya Faridi, Daniel Figeys, George Fu Gao, Wen Gao, Zu-Hua Gao, Keisuke Goda, Wilson Wen Bin Goh, Dongfeng Gu, Changjiang Guo, Tiannan Guo, Yuezhong He, Albert J R Heck, Henning Hermjakob, Tony Hunter, Narayanan Gopalakrishna Iyer, Ying Jiang, Connie R Jimenez, Lokesh Joshi, Neil L Kelleher, Ming Li, Yang Li, Qingsong Lin, Cui Hua Liu, Fan Liu, Guang-Hui Liu, Yansheng Liu, Zhihua Liu, Teck Yew Low, Ben Lu, Matthias Mann, Anming Meng, Robert L Moritz, Edouard Nice, Guang Ning, Gilbert S Omenn, Christopher M Overall, Giuseppe Palmisano, Yaojin Peng, Charles Pineau, Terence Chuen Wai Poon, Anthony W Purcell, Jie Qiao, Roger R Reddel, Phillip J Robinson, Paola Roncada, Chris Sander, Jiahao Sha, Erwei Song, Sanjeeva Srivastava, Aihua Sun, Siu Kwan Sze, Chao Tang, Liujun Tang, Ruijun Tian, Juan Antonio Vizcaíno, Chanjuan Wang, Chen Wang, Xiaowen Wang, Xinxing Wang, Yan Wang, Tobias Weiss, Mathias Wilhelm, Robert Winkler, Bernd Wollscheid, Limsoon Wong, Linhai Xie, Wei Xie, Tao Xu, Tianhao Xu, Liying Yan, Jing Yang, Xiao Yang, John Yates, Tao Yun, Qiwei Zhai, Bing Zhang, Hui Zhang, Lihua Zhang, Lingqiang Zhang, Pingwen Zhang, Yukui Zhang, Yu Zi Zheng, Qing Zhong, Yunping Zhu, Π-Hub Consortium

Faculty, Staff and Students Publications

The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual's body during their lifetime. Understanding the complexities of the proteome in the context of a human organism and its many potential states is a necessary requirement to understanding human biology, but these complexities can neither be predicted from the genome, nor have they been systematically measurable with available technologies. Recent advances in proteomic technology and computational sciences now provide opportunities to investigate the intricate biology of the human body …

The Role Of Porphyromonas Gingivalis In Inducing Il-6 Macrophages Expression In Ovaries Of Periodontitis Models, Agustin Ws. Dharmayanti, Ernie M. Setiawatie, Hendy Hendarto

Journal of Dentomaxillofacial Science

Objective: This study aimed to determine whether P. gingivalis induction in the gingival sulcus increased IL-6 expression by macrophages in the ovaries.

Material and Methods: This research was a laboratory experiment using a post-test-only control group design, using female white rats strain Sprague Dawley, six weeks old and in the estrous phase. They were divided into the control and treatment groups. The animal models were induced with P. gingivalis in the mesial gingival sulcus of their first right and left lower jaw molars, with 0.05 ml every three days for 19 days. On 0, 7, 14 days after bacteria induction, …

Relationship Between Risk Factors Of Dysphagia, Occlusal Tooth Contact And Oral Health-Related Quality Of Life In The Elderly, Muslita Indrasari, Lindawati S. Kusdhany, Randi Dias

Journal of Dentomaxillofacial Science

Objective: Tooth loss and changes in the swallowing mechanism in the aging process can lead to dysphagia. Individuals who are at risk of experiencing dysphagia have an impact on the health and quality of life and contribute to the cost of health care. The aim of this study to analyze the relationship between risk factors of dysphagia, occlusal tooth contact and oral health-related quality of life (OHRQoL) and find out which factors contribute the most to OHRQoL among the elderly.

Material and Methods: This cross-sectional study using consecutive sampling method from 121 respondents aged 60 years and over. The General …

Exploring Drivers Of Women’S Well-Being In Hospitals: Mapping The Landscape, Mitra Faghihi, Aliasghar Farshad, Nasim Salehi, Dean Whitehead, Masoud Motalebi Ghayen, Bahar Izadi, Morteza Mansourian

Research outputs 2022 to 2026

Background and purpose: The workplace plays a key role in impacting the health and well-being of employees at various levels, including physical, psychological, and social aspects of health. This study aims to identify the drivers of a healthy environment that promotes the well-being of women employed in hospitals. Materials & methods: This qualitative study used purposive sampling to recruit a total of 48 working women across a diverse range of participants with different job categories and socio-demographic statuses. These include clinical health (e.g., nurse, head nurse, practical nurse, supervisor, physicians); allied health (e.g., diagnostic services); public health (e.g., health promotion …

December 2024: Region 10 Emerging Special Pathogen Treatment Center (Resptc) At Providence Sacred Heart Medical Center & Children’S Hospital, Providence - Special Pathogens Program

Special Pathogens Newsletters

REGION 10 SPECIAL PATHOGENS NEWSLETTER

Exploring Treatment Burden In People With Type 2 Diabetes Mellitus: A Thematic Analysis In China's Primary Care Settings, Kai Lin, Mi Yao, Lesley Andrew, Rouyan Li, Yilin Chen, Jacques Oosthuizen, Moira Sim, Yongsong Chen

Research outputs 2022 to 2026

Background: Understanding treatment burden is a critical element to the effective management of Type 2 Diabetes Mellitus (T2DM). The current study aims to address the knowledge gap surrounding treatment burden of T2DM from the patient’s perspective in China’s primary care settings. Methods: A narrative review informed the creation of an a priori coding structure to identify aspects of T2DM treatment burden. Focus groups were conducted, employing a maximum variation sampling strategy to select participants from diverse sociodemographic backgrounds across urban, suburban, rural, and remote areas in China. Participants included adults with T2DM care in primary care settings for over a …

The Provision Of Healthcare For Older Adults In A Massachusetts Jail/House Of Correction: Perspectives From Providers, Laura Driscoll

Graduate Doctoral Dissertations

THE PROVISION OF HEALTHCARE FOR OLDER ADULTS IN A MASSACHUSETTS JAIL/HOUSE OF CORRECTION: PERSPECTIVES FROM PROVIDERS November 2024 Laura C. Driscoll, B.S., Boston University M.S.P.T., Boston University DPT, MGH Institute of Health Professions M.S., University of Massachusetts Boston Ph.D., University of Massachusetts Boston Directed by Professor Jan Mutchler The aging population in U.S. jails is growing rapidly presenting significant challenges for healthcare provision within carceral settings. Older adults in these facilities often experience complex health conditions, including chronic diseases and age-related impairments, that require specialized care. Despite this, limited research has explored the experiences of healthcare providers tasked with caring …

Introducing A Practitioner's Framework For Mobilizing Collective Action, Matthew Paul Bond

Graduate Doctoral Dissertations

INTRODUCING A PRACTITIONER’S FRAMEWORK FOR MOBILIZING COLLECTIVE ACTION December, 2024 Matthew P. Bond, B.A. University of North Carolina Greensboro, M.S., University of Massachusetts Boston, M.P.A., Suffolk University, Ph.D., University of Massachusetts Boston Directed by Christian Weller Social dilemmas are situations in which individual and collective incentives are at odds, leading to suboptimal collective outcomes that make all individuals worse off. Modeling policy problems stuck in stasis as social dilemmas reveals new solution pathways that promise progressive change. The solution to a social dilemma is collective action, yet since the introduction of the collective action problem in the 1960’s, a solution …

Size Matters: The Characterization Of Telomere Function In Germ Cell Development In Danio Rerio, Jessica Macneil

Graduate Doctoral Dissertations

Infertility is a growing problem worldwide. According to the WHO, 48 million couples across the globe suffer from infertility and many couples turn to Assisted Reproductive Technology (ART) to become pregnant. One readout of gamete quality and successful ART is telomere integrity because telomeres are necessary for chromosome movements during meiosis so that the segregation of chromosomes happens correctly. Telomeres are well known for their role in aging; however, they play an important and understudied role during meiosis. In meiosis, telomeres attach to the nuclear envelope (NE) via a protein chain spanning the NE that interacts with cytoplasmic motor proteins, …

Democratizing The Early Identification Of Alzheimer's Disease And Access To Care: The Role Of Psychologists In Brief Assessment, Jacqueline S. Hogan

Graduate Doctoral Dissertations

As Alzheimer’s disease (AD) presents a growing public health challenge, accessible early detection tools are urgently needed. This study used data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (N = 1,536) to evaluate the ability of machine learning models to predict a conversion from normal cognition or mild cognitive impairment (MCI) to AD. A brief neuropsychological battery, including the Alzheimer’s Disease Assessment Scale–Cognitive Subscale (ADAS13), Mini-Mental State Examination (MMSE), Rey Auditory Verbal Learning Test (RAVLT), and Functional Activities Questionnaire (FAQ), was employed. The Gradient Boosted Trees model demonstrated superior performance, achieving an F1 score of 0.88, recall of 0.93, precision …

Removing Methane Via Soil Amendments: The Legal Framework, Korey Silverman-Roati, Romany M. Webb

Sabin Center for Climate Change Law

Rapid and sustained reductions in human-driven methane emissions are critical to limiting warming in line with the 2015 Paris Agreement. Reductions in certain methane emissions, particularly from the fossil fuel sector, can be implemented cheaply and efficiently. Other forms of methane emissions, like those from agricultural sources, are more difficult to control. This fact, coupled with concerns that climate change could unlock significant additional natural emissions from tropical wetlands and melting permafrost, has increased interest in atmospheric methane removal (“AMR”).

AMR refers to human interventions to accelerate the conversion of methane in the atmosphere to a form that causes less …

Supporting Cancer-Related Fatigue Self-Management: A Conversation Analytic Study Of Nurse Counsellor And Cancer Survivor Consultations, Oluwaseyifunmi Andi Agbejule, Stuart Ekberg, Nicolas H. Hart, Raymond J. Chan

Research outputs 2022 to 2026

Purpose: Cancer-related fatigue (CRF) is a prevalent and distressing symptom experienced by people affected by cancer. A breakdown of the clinician-patient partnership and suboptimal clinician communication has been identified as a significant barrier to implementing into clinical practice effective self-management strategies for CRF. This study examined the use and impact of communication practices employed by trained cancer nurse counsellors when providing CRF self-management support to cancer survivors.

Methods: Interactions from 41 telehealth consultations between three nurse counsellors and 23 cancer survivors in a CRF self-management support clinic in Queensland, Australia were recorded and analysed using conversation analysis methods.

Results: Analysis …

Response: Use Of The Wisci-Ii Score In Assessing Outcome Of Intensive Robot-Assisted Gait Training In Spinal Cord Injury, Dylan J. Edwards, A. Jayaraman

Research outputs 2022 to 2026

No abstract provided.

Gc-Ms Analysis And Evaluation Of Antioxidant, Anticancer, Cytotoxicity, And Hypoglycemic Properties Of The Libyan Moringa Oleifera Leaf Extract On Alloxan-Induced Diabetes In Mice, Osama Abdel-Hafeez Mohammed Al-Bedak, Ahlam Rashed, Seham T.M. Oskandali, Nouri Kushlaf, Amal Eishebani, Samira A. Alacrouk, Fadia T.M. Oshkandale, Manal Eisheli, Zahur R. Almesai, Ameerah Shaeroun, Steven L. Stephenson, Fuad Ameen

Biological Sciences Faculty Publications and Presentations

Libyan Moringa oleifera leaves were extracted using methanol, and the bioactive components' antibacterial, antioxidant, anti-inflammatory, and anticancer characteristics were assessed using gas chromatography mass spectrometry analysis (GC-MS). Moringa oleifera exhibited antioxidant activity, with an IC50 of 11.53 µg/mL. Wi38 cell line's viability decreased with increasing M. oleifera extract concentration, while its cytotoxicity increased with an IC50 of 393.41±7.77 μg/mL. Alloxan-induced diabetes model in Swiss albino mice was implemented. Three different doses (100, 200, or 300 mg/kg of mice body weight) of M. oleifera’s extract were evaluated for their effects on blood sugar concentration and the histology of the pancreatic islets. …

Examining Aid Fragmentation And Collaboration Opportunities In Cambodia’S Health Sector, Suyeon Lee, Eunice Y. Park

Department of Public Health Scholarship and Creative Works

Background: Cambodia’s health sector faces significant challenges exacerbated by aid fragmentation, where development aid is dispersed among numerous small, uncoordinated projects. This study examines the distribution of health sector aid among Cambodia’s principal donors to identify priorities, overlaps, and potential collaboration opportunities, addressing the urgent need for aid efficiency and alignment with national health priorities. Methods: Utilizing OECD datasets and the Herfindahl-Hirschman Index (HHI) for the years 2010–2021, this study quantifies aid fragmentation within Cambodia’s health sector. It analyzes aid allocations from the top five donors—United States, Australia, South Korea, Japan, and Germany—across various health projects and initiatives, evaluating the …

Breastfeeding Among Women Employed In Mexico’S Informal Sector: Strategies To Overcome Key Barriers, Julia M. Goodman, Vania Lara-Mejía, Sonia Hernández-Cordero, Mireya Vilar-Compte

Department of Public Health Scholarship and Creative Works

Background: Rates of exclusive breastfeeding fall below recommended levels, particularly among women in paid employment. In Mexico, more than half of women are in informal employment, meaning they lack many of the protections that may support breastfeeding. Methods: In-depth interviews with 15 key informants representing government agencies (n = 6 organizations), NGOs (n = 4), international organizations (n = 2), and academia (n = 2) in Mexico. Interviews were conducted between March and June 2023. To understand and describe barriers to breastfeeding among informally employed women in Mexico according to key informants and the current and potential policies to address …

Commercial Milk Formula Marketing Entry Points: Setting The Course Of Infant And Young Child Feeding Trajectories, Mireya Vilar-Compte, Sonia Hernández-Cordero, Rafael Pérez-Escamilla, Cecília Tomori

Department of Public Health Scholarship and Creative Works

Background: There is a limited understanding of the dynamic influences that shape infant and young child feeding (IYCF) decisions over time. We conducted an innovative qualitative study to reconstruct IYCF trajectories across early life course phases, in the context of the socioecological model (SEM) and the commercial determinants of IYCF. Methods: Women of different socioeconomic status were interviewed in two large metropolitan areas in Mexico. Our specific goal was to allow us to better understand if and how the commercial milk formula (CMF) marketing influenced breastfeeding decisions in a complex dynamic way involving the individual, relational, community and societal levels. …

Vol 69 #6, Melanie Argo

MPLA Newsletter

No abstract provided.

Engaging Families In School-Based Physical Activity Promotion, Veronica Becerra

Dissertations

This dissertation explored how schools promote and engage families in physical activity (PA) opportunities through two studies conducted in a Mountain West state. Study one explored strategies schools used to engage families in PA. Study two examined how a purposefully selected K-8 school developed family-school partnerships to support PA engagement through Epstein’s (2010) Six Types of Involvement framework.

Study one used a collective case study design guided by the following research questions:

• Q1.1 What strategies do schools implement to promote and engage families in physical activity programming?
• Q1.1a What tactics do schools use to implement these strategies?
• Q1.2 What are …

Study Of Yoga Intervention To Reduce Secondary Traumatic Stress Among Public School Educators, Leslie Marie Hillen

Dissertations

A problem in education was the great amount of stress teachers were under. Secondary Traumatic Stress “is the emotional duress that results when an individual hears about the first-hand trauma experiences of another” (The National Child Traumatic Stress Network, n.d.). When teachers feel they cannot work or are overwhelmed with the demands of education, this can be attributed to Secondary Traumatic Stress (STS) (Caringi et al., 2015). Many teachers felt there was not enough support from the administration, as they not only deliver curriculum, but they also worried about the students’ mental health, home lives, hunger, and how to support …

University Students With Attention-Deficit/Hyperactivity Disorder: Sex Differences In Identification And Diagnosis, Lisa Mickelson

Dissertations

University students with attention-deficit/hyperactivity disorder (ADHD) face several risk factors and challenges compared to peers without ADHD that can impede their academic success and graduation. It is important to identify and diagnose ADHD prior to entering postsecondary settings to provide students with the best academic trajectory. This is particularly true as the number of students enrolled at universities with ADHD increases. Historically, ADHD has been considered a disorder with a childhood onset. However, past research primarily focused on males. More recent studies suggest females have a different ADHD etiological presentation than males, and that onset is more likely to occur …

Patterns Of Cannabis Use And Impacts On Communication And Relationship Satisfaction, Johni Mitchell

Dissertations

This dissertation looked at patterns of cannabis use and impacts on communication and relationship satisfaction in couples that have been co-habitating for at least a year. A sample of 299 individual participants aged 21-69 were split into groups to look at concordant (where both partners either used or abstained from cannabis use) and discordant (where one partner used and the other abstained) relationship dynamics. The research revealed significant differences in communication and relationship satisfaction across these groups. Individuals in concordantabstaining partnerships reported higher levels of communication and relationship satisfaction compared to concordant-using couples. The lowest satisfaction levels were observed in …

Exploring The Motivations And Aspirations Of High School Senior Latinas: A Phenomenological Constructivist Study Of Advancement Via Individual Determination And Non-Advancement Via Individual Determination Student Experiences, Marina Rodriguez

Dissertations

While student support programs aim to offer guidance on college information and resources, not all student support programs offer a class curriculum targeted toward college and career readiness. The Advancement Via Individual Determination (AVID) program offers AVID as an elective class in a student’s academic schedule. Similar programs that support students include the Migrant Education Program, TRIO, and Gaining Early Awareness and Readiness for Undergraduate Programs. The purpose of this study was to establish a greater understanding of the motives and aspirations to attend a higher education institution of Latina high school seniors who have participated in an AVID program …

After The Bullets: Managing A Mass Shooting Resource Center Explored Through Autoethnography, Karen Allene Schweihs

Dissertations

The rate of mass shootings has more than doubled over the past 10 years in the United States (Gun Violence Archive, 2024). The focus of this study was a thorough exploration of my personal experiences in designing a response center after a mass shooting occurred in Boulder, Colorado. This study utilized a qualitative narrative inquiry form of research methodology called autoethnography. Autoethnography has been utilized to capture more than the raw data collected, but to offer a more expansive and detailed description of a unique experience. The following research questions were studied:

• Q1 What might I learn about my own …

The Fields Of Care Project: Diabetes Education For Agricultural Laborers Of Stockton, California, Matthew Medel, Juan Fernando Rosero, Valerie Visochin, Antonella Winer

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

No abstract provided.