Digital Commons Network^™

Bad To The [Jaw]Bone: How Courts Should Approach First Amendment Jawboning Challenges, Christopher Frey

Seton Hall Law Review

No abstract provided.

Neuroprotective Care And Painful Procedures, Jelda Frank

Walden Dissertations and Doctoral Studies

An inconsistent application of neuroprotective care provided by clinical staff, based on my observations, to minimize the negative effects of painful procedures that can negatively impact the neurodevelopment of neonates in the neonatal intensive care unit (NICU), was the identified practice problem for my Doctor of Nursing Practice (DNP) staff education project. Implementation of evidence-based neuroprotective and neuropromotive strategies aim to optimize outcomes for premature infants and minimize risk of potential negative effects to the neonate’s short and long term neurodevelopment. The DNP project practice-focused question addressed whether a presentation of an evidence-based educational program for NICU clinical staff would …

Indefinite Isolation: Rethinking The Relationship Between The Fourteenth Amendment And Prolonged Solitary Confinement, Katherine Farmer

Seton Hall Law Review

No abstract provided.

Attracting And Retaining Employees For A Mid-Atlantic Nonprofit Organization, Owolabi Kehinde

Walden Dissertations and Doctoral Studies

The purpose of this qualitative study was to explore the perspectives of employees at a Mid-Atlantic nonprofit regarding their satisfaction and to develop a strategic plan to address the organization's challenges. This study utilized a qualitative case study design with data collected through semistructured interviews. The research questions focused on understanding employee satisfaction, perceptions of improving quality of life, and strategies for attracting new talent. Data for this study was from 12 participants who provided in-depth insights through one-on-one interviews which were analyzed using thematic analysis. Resulting key themes were (a) employee satisfaction was high, (b) quality of life for …

Documents From The December 3, 2024 Meeting Of The Associated Students Of The University Of Montana (Asum), Associated Students Of The University Of Montana

Senate Meeting Agendas and Minutes, 2007-Present

Agenda and meeting minutes from the December 3, 2024 meeting of the Associated Students of the University of Montana (ASUM).

Correction: Nepali Oral Microbiomes Reflect A Gradient Of Lifestyles From Traditional To Industrialized, Erica P Ryu, Yoshina Gautam, Diana M Proctor, Dinesh Bhandari, Sarmila Tandukar, Meera Gupta, Guru Prasad Gautam, David A Relman, Ahmed A Shibl, Jeevan Bahadur Sherchand, Aashish R Jha, Emily R Davenport

Faculty, Staff and Student Publications

No abstract provided.

The Prospector, December 3, 2024, Utep Student Publications

The Prospector

No abstract provided.

Qatar Dental Student Perceptions Of Sirona Prep-Check Software For Learning Crown Preparations, Hanin Daas, María Arregui, Lluís Giner Tarrida, Rebecca Glanville, Kamran Ali

Peninsula Dental School

Background: Contemporary dental education requires swift assimilation of technological advancements to prepare the future generation of dentists. Integrating digital tools, such as prepCheck software in crown preparations offers a promising avenue for enhancing the learning experiences of dental students. This study aimed to evaluate the perceptions and experiences of undergraduate dental students regarding the use of PrepCheck software for learning crown preparations. Methods: An interventional study design was employed to investigate the perceptions of undergraduate dental students regarding the use of Sirona prepCheck software their learning experiences in the prosthodontics course at the College of Dental Medicine. were recruited using …

Occupational Therapy In Pain Management: An Exploration And Description Of Current Uk Practice, Rebecca Slee, Alison Warren, Miriam Noonan, Tristan Henderson

School of Health Professions

Introduction: There is a growing body of evidence regarding the contribution to the management of chronic pain by occupational therapists. However, there is limited research available regarding contemporary practice in the United Kingdom (UK). Method: An on-line questionnaire was circulated via social media, profession specific publications and specialist interest groups. Responses were requested from UK-based Health and Care Professions Council registered occupational therapists who identified working with those living with chronic pain and their friends, family and supporters. Findings: A total of 26 occupational therapists responded. Occupational therapists are working in diverse service settings, offering a range of interventions and …

What Are The Views Of Those Participating In A Trial Investigating Acute Post-Traumatic Benign Paroxysmal Positional Vertigo? A Qualitative Study, Rebecca M. Smith, Bithi Sahu, Caroline Burgess, Jenna Beattie, Abby Newdick, Vassilios Tahtis, Jonathan Marsden, Barry M. Seemungal

School of Health Professions

Objective: The purpose of this study was to explore the experiences of patients and healthcare professionals participating in a randomized feasibility trial exploring the management of acute post-traumatic benign paroxysmal positional vertigo (BPPV), and to establish the acceptability and tolerability of BPPV assessment and treatment procedures. Methods: This was a multi-center qualitative study nested within a wider randomized feasibility trial. Purposive sampling was used to gather a cohort of healthcare professionals and patients from three major trauma centres in London, UK. Data were gathered using semi-structured interviews and were analyzed using Framework analysis. Results: Fifteen healthcare professionals and 26 patients …

Investigating Current Clinical Practice In The Prevention Of Hemiplegic Shoulder Pain: A Survey Of Neuro-Therapists In The Uk, Sarah Bradfield, Lisa Bunn

School of Health Professions

IntroductionHemiplegic shoulder pain (HSP) is a common medical complication following stroke, that impacts the overall functional outcomes of the person with stroke (PWS). While prevention is key, clinical guidelines offer little guidance on how to effectively achieve this. This study aimed to investigate neuro-therapists (Occupational Therapists and Physiotherapists) current clinical practice to prevent HSP.MethodsA cross-sectional, online survey was designed, piloted and distributed through specialist interest groups, social media and encouraging sharing of the link. The survey was open for six months. Results were analysed using descriptive statistics.ResultsThe study received 137 responses. The majority of respondents (n=119, 86.7%) reported they screened …

Sustainable Eco-Friendly Packaging, Kyla Barrett

Sustainable Supply Chain Management

Plastic pollution is one of the most pressing environmental challenges today, threatening marine ecosystems and global environmental health. With 8 to 10 million metric tons of plastic entering our oceans annually, the urgency to implement sustainable practices in packaging has never been greater. This chapter explores the environmental impact of single-use plastics and highlights innovative alternatives like bioplastics and compostable materials. Lessons from global leaders, like Japan's cultural approach to waste management, the European Union's Circular Economy Action Plan, and Costco's efforts in bulk buying and sustainable design, the chapter identifies actionable strategies for industries to adopt eco-friendly practices. Concluding …

Butte Priority Soils Operable Unit (Bpsou) Final Bpsou Insufficiently Reclaimed Sites Belle Of Butte (Bres No. 8 & Ur-39) Remedial Action Work Plan (Rawp) Request For Change Ir- 2024-Ra-01, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Breaking The Yoke: A Systematic Unmasking Of Challenges To Sustainable Rural Development In South Sudan, Gai Chol Paul

Journal of Sustainable Social Impact

South Sudan, a young nation grappling with the legacy of protracted conflict, faces significant challenges in fostering sustainable rural development. While the immense potential of its vast agricultural lands remains largely untapped, the persistent triple threat of insecurity, deficient infrastructure, and the absence of robust government policy actively hinders progress. The ongoing armed conflict, characterized by inter-communal violence and sporadic attacks, casts a long shadow over rural areas in South Sudan. Thus, I developed this mixed-method multiple-case study, grounded in the sustainable livelihoods framework, to explore challenges that hinder sustainable rural development in South Sudan. I collected data through document …

Phosphorylation Of Disordered Proteins Tunes Local And Global Intramolecular Interactions, Emery T Usher, Martin J Fossat, Alex S Holehouse

2020-Current year OA Pubs

Protein post-translational modifications, such as phosphorylation, are important regulatory signals for diverse cellular functions. In particular, intrinsically disordered protein regions (IDRs) are subject to phosphorylation as a means to modulate their interactions and functions. Toward understanding the relationship between phosphorylation in IDRs and specific functional outcomes, we must consider how phosphorylation affects the IDR conformational ensemble. Various experimental techniques are suited to interrogate the features of IDR ensembles; molecular simulations can provide complementary insights and even illuminate ensemble features that may be experimentally inaccessible. Therefore, we sought to expand the tools available to study phosphorylated IDRs by all-atom Monte Carlo …

Epigenetic Modifiers: Exploring The Roles Of Histone Methyltransferases And Demethylases In Cancer And Neurodegeneration, Lauren Reed, Janak Abraham, Shay Patel, Shilpa S Dhar

Faculty, Staff and Student Publications

Histone methyltransferases (HMTs) and histone demethylases (HDMs) are critical enzymes that regulate chromatin dynamics and gene expression through the addition and removal of methyl groups on histone proteins. HMTs, such as PRC2 and SETD2, are involved in the trimethylation of histone H3 at lysine 27 and lysine 36, influencing gene silencing and activation. Dysregulation of these enzymes often leads to abnormal gene expression and contributes to tumorigenesis. In contrast, HDMs including KDM7A and KDM2A reverse these methylation marks, and their dysfunction can drive disease progression. In cancer, the aberrant activity of specific HMTs and HDMs can lead to the silencing …

Arousal Effects On Oscillatory Dynamics In The Non-Human Primate Brain, Shashank A Anand, Fatih Sogukpinar, Ilya E Monosov

2020-Current year OA Pubs

Arousal states are thought to influence many aspects of cognition and behavior by broadly modulating neural activity. Many studies have observed arousal-related modulations of alpha (~8 to 15 Hz) and gamma (~30 to 50 Hz) power and coherence in local field potentials across relatively small groups of brain regions. However, the global pattern of arousal-related oscillatory modulation in local field potentials is yet to be fully elucidated. We simultaneously recorded local field potentials in numerous cortical and subcortical regions in the primate brain and assessed oscillatory activity and inter-regional coherence associated with arousal state. In high arousal states, we found …

Molecular Insights Into The Interaction Between A Disordered Protein And A Folded Rna, Rishav Mitra, Emery T Usher, Selin Dedeoğlu, Matthew J Crotteau, Olivia A Fraser, Neela H Yennawar, Varun V Gadkari, Brandon T Ruotolo, Alex S Holehouse, Loïc Salmon, Scott A Showalter, James C A Bardwell

2020-Current year OA Pubs

Intrinsically disordered protein regions (IDRs) are well established as contributors to intermolecular interactions and the formation of biomolecular condensates. In particular, RNA-binding proteins (RBPs) often harbor IDRs in addition to folded RNA-binding domains that contribute to RBP function. To understand the dynamic interactions of an IDR-RNA complex, we characterized the RNA-binding features of a small (68 residues), positively charged IDR-containing protein, Small ERDK-Rich Factor (SERF). At high concentrations, SERF and RNA undergo charge-driven associative phase separation to form a protein- and RNA-rich dense phase. A key advantage of this model system is that this threshold for demixing is sufficiently high …

Assessing The Prevalence Of Malnutrition In St. Jude Children's Hospital: A Quality Improvement Study, Maria Jose Urbina Turcios

Electronic Theses and Dissertations Archive

Introduction: Malnutrition is a worldwide problem that affects the patient’s overall health. Malnutrition often goes undiagnosed, especially when it comes to over nutrition. According to The World Health Organization (WHO), malnutrition refers to the deficiencies, excesses or imbalances in a person’s intake of energy and/or nutrients.1 Methods: A quality improvement (QI) study was conducted between November 1st 2023 to March 15th 2024 at St. Jude Children’s Research Hospital. QI consisted of a detailed list of the outpatient clinic patients seen within this time frame. A report, called St Jude Nutrition Risk Report, was created through EPIC database and the IT …

Mechanical Degradation Of Plastics: An Implication For Agricultural Soil Health, Linkon Bhattacharjee

Electronic Theses and Dissertations Archive

The growing public awareness of plastic pollution and its harmful environmental impacts on public health and ecological safety has raised multiple questions regarding the rate of its accumulation, long-term fate, and transport within the environment. However, the extent of plastic release into the terrestrial environment, such as farmlands, remains inadequately understood, though it is expected to exceed that of the ocean. Therefore, this dissertation focuses on investigating the mechanical degradation of plastics that leads to the generation of microplastics through fragmentation in agricultural farmlands. This dissertation addresses several knowledge gaps regarding the influence of environmental conditions on the mechanical degradation …

On The Logistic Polynomials And Logistic Kernels With Applications In Machine Learning, Alexander Saint Jefferson

Electronic Theses and Dissertations Archive

Orthogonal polynomials have had vast historical applications in applied mathematics, particularly in differential equations and numerical analysis. In recent years, they have become instrumental as a natural basis for constructing kernel systems in machine learning (ML). In this thesis, we orthogonalize a set of polynomials, the Logistic Polynomials, first developed by George and Rousseau, using the Gram-Schmidt process. We show that this new Logistic Orthogonal Polynomial System (LOPS) satisfies the hypergeometric differential equation and we relate the system to the Legendre polynomials. The connection to the Legendre polynomials has motivated this study to explore applications of the LOPS in ML, …

The Impacts Of Co-Occurring Developmental Language Disorder On The Academic, Interpersonal, And Behavioral Profiles Of Children With Adhd, Kirsten M. Hannig Russell, Sean M. Redmond

Faculty Publications

Purpose: Attention-deficit/hyperactivity disorder (ADHD) is a multifactorial disorder that has been linked to increased risk for behavioral, academic, and interpersonal problems. Developmental language disorder (DLD) has also been linked to poor outcomes in these areas. The presence of co-occurring disorders in children’s profiles is generally associated with poorer outcomes relative to profiles consisting of only one disorder. This study investigated the extent to which co-occurring DLD in children already identified with ADHD presented increased risk for severity of their primary ADHD symptoms, the presence of secondary behavioral problems, and/or increased problems in the tertiary areas of academic performance and interpersonal …

Using The Lehmer Mean To Assess Business Data Protection: Statistical Disclosure Control And The Truncated Moment Problem, Mark Stander, Julian Stander

School of Engineering, Computing and Mathematics

Confidential business data needs protection against disclosure. Often this data is protected by releasing sample means, variances and higher power moments. Motivated by statistical disclosure control obligations and the need to publish business data safely, we explain how calculating the Lehmer mean from released power moments can lead to the unwanted disclosure of the largest data value. We explain how similar disclosure can apply to smaller data values and provide an approximate solution to the Truncated Moment Problem. We briefly discuss the Gini mean and the relationship between sample central and raw moments.

Pragmatist-Critical Realism As A Development Studies Research Paradigm, Richard Heeks, P. J. Wall, Mark Graham

Research Outputs: 2025-Present

No abstract provided.

Cardiac Output-Guided Haemodynamic Therapy For Patients Undergoing Major Gastrointestinal Surgery: Optimise Ii Randomised Clinical Trial, Optimise Ii Trial Group, Mark R. Edwards, Mark R. Edwards, Rupert M. Pearse, Brennan C. Kahan, Thomas Hamborg, Garima Priyadarshini, Neil Macdonald, Borislava Mihaylova, Vladimir Gordeev, Esubalew Assefa, Priyanthi Dias, Ann Thomson, Michael P.W. Grocott, Monty G. Mythen, Michael A. Gillies, Michael Sander, Tuong Phan, Lisbeth Evered, Duminda N. Wijeysundera, Stuart A. Mccluskey, Andrew D. Shaw, Mitchell Weinstein, Cesar Aldecoa, Javier Ripollés-Melchor, Christoph K. Hofer, Hussein Abu Khudair, Wojciech Szczeklik, Ioana Grigoras

Peninsula Medical School

OBJECTIVES To evaluate the clinical effectiveness and safety of a perioperative algorithm for cardiac output-guided haemodynamic therapy in patients undergoing major gastrointestinal surgery. DESIGN Multicentre randomised controlled trial. SETTING Surgical services of 55 hospitals worldwide. PARTICIPANTS 2498 adults aged ≥65 years with an American Society of Anesthesiologists physical status classification of II or greater and undergoing major elective gastrointestinal surgery, recruited between January 2017 and September 2022. INTERVENTIONS Participants were assigned to minimally invasive cardiac output-guided intravenous fluid therapy with low dose inotrope infusion during and four hours after surgery, or to usual care without cardiac output monitoring. MAIN OUTCOME …

Loss Of Trace Elements From Agricultural Soil, S. D.W. Comber, R. J. Schindler, M. S.A. Blackwell, T. Darch

School of Geography, Earth and Environmental Sciences

Soil erosion is a world-wide issue driven by land management and climate change. Research has focussed on soil loss rates from agricultural land. However, the loss of trace elements essential for soil and plant health, or potentially toxic elements that occur as impurities in fertilisers and manures, is poorly understood. This study reports on the loads and forms of copper, cadmium, manganese, nickel, selenium and zinc lost from three types of agricultural systems at Rothamsted Research’s North Wyke Farm Platform over five individual storm events. Loads reflected a combination of concentrations in the soil, annual additions from fertilisers, the ability …

Nutritional Potential And Antioxidant Activity Of Dioscorea Spp. Tubers From Mtwara Rural District, Tanzania, Tumsifu S. Mwanjala, Washa B. Washa, Stephen I. Nnungu

Tanzania Journal of Science

The wild yam Dioscorea hirtiflora subsp. orientalis, native to the Mtwara rural district in Tanzania, remains underutilized despite its considerable nutritional and health benefits. This study aimed to assess the nutritional composition and antioxidant properties of its tubers. Standard AOAC procedures were employed to analyze dried tuber samples, while antioxidants and antioxidant capacity were evaluated. The tuber was found to have carbohydrates content ranging from 21.02% to 23.57%, crude protein from 1.0% to 1.5%, crude lipids between 0.46% and 0.68%, and crude fiber from 11.26% to 13.52%, with an energy value of 97.26 to 101.1 Kcal/100 g. Vitamin C content …

Using Multiplexed Functional Data To Reduce Variant Classification Inequities In Underrepresented Populations, Moez Dawood, Shawn Fayer, Sriram Pendyala, Mason Post, Divya Kalra, Karynne Patterson, Eric Venner, Lara A Muffley, Douglas M Fowler, Alan F Rubin, Jennifer E Posey, Sharon E Plon, James R Lupski, Richard A Gibbs, Lea M Starita, Carla Daniela Robles-Espinoza, Willow Coyote-Maestas, Irene Gallego Romero

Faculty, Staff and Students Publications

BACKGROUND: Multiplexed Assays of Variant Effects (MAVEs) can test all possible single variants in a gene of interest. The resulting saturation-style functional data may help resolve variant classification disparities between populations, especially for Variants of Uncertain Significance (VUS).

METHODS: We analyzed clinical significance classifications in 213,663 individuals of European-like genetic ancestry versus 206,975 individuals of non-European-like genetic ancestry from All of Us and the Genome Aggregation Database. Then, we incorporated clinically calibrated MAVE data into the Clinical Genome Resource's Variant Curation Expert Panel rules to automate VUS reclassification for BRCA1, TP53, and PTEN.

RESULTS: Using two orthogonal statistical approaches, we …

Prenatal Assessment Of Brain Malformations On Neuroimaging: An Expert Panel Review, Ivana Pogledic, Kshitij Mankad, Mariasavina Severino, Tally Lerman-Sagie, Andras Jakab, Efrat Hadi, Anna C Jansen, Nadia Bahi-Buisson, Natalya Di Donato, Renske Oegema, Christian Mitter, Ivan Capo, Matthew T Whitehead, Parthiv Haldipur, Grazia Mancini, Thierry A G M Huisman, Andrea Righini, Bill Dobyns, James A Barkovich, Natasa Jovanov Milosevic, Gregor Kasprian, Maarten Lequin

Faculty, Staff and Students Publications

Brain malformations represent a heterogeneous group of abnormalities of neural morphogenesis, often associated with aberrations of neuronal connectivity and brain volume. Prenatal detection of brain malformations requires a clear understanding of embryology and developmental morphology through the various stages of gestation. This expert panel review is written with the central aim of providing an easy-to-understand road map to improve prenatal detection and characterization of structural malformations based on the current understanding of normal and aberrant brain development. For every developmental stage, the utility of each available neuroimaging modality, including prenatal multiplanar neuro sonography, anatomical MRI and advanced MRI techniques, as …

Nt-Probnp And Cardiac Troponin I, But Not Cardiac Troponin T, Are Associated With 7-Year Changes In Cardiac Structure And Function In Older Adults: The Aric Study, Peder L Myhre, Brian Claggett, Christie M Ballantyne, Ron C Hoogeveen, Elizabeth Selvin, Kunihiro Matsushita, Dalane Kitzman, Suma Konety, Thomas Mosley, Amil M Shah

Faculty, Staff and Students Publications

Background: Higher circulating concentrations of NT-proBNP (N-terminal pro-B-type natriuretic peptide) and high-sensitivity cardiac troponin T (hs-cTnT) and I (hs-cTnI) are associated with left ventricular remodeling and with incident heart failure. The associations of these cardiac biomarkers with changes in cardiac structure and function over time are uncharacterized.

Methods: Among 2006 participants in the ARIC prospective cohort study (Atherosclerosis Risk in Communities) who were free of overt cardiovascular disease and underwent echocardiography at study visits 5 (2011- 2013) and 7 (2018-2019), we assessed the associations of NT-proBNP, hs-cTnT, and hs-cTnI concentrations at visit 5 with changes in left ventricular structure and …