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Systemic Antibiotic Selection In Skin And Soft Tissue Infections, Shafira Anindya Purnawan, Windy Keumala Budianti, Sandra Widaty

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Antibiotics are used in daily practice. To properly select antibiotics, it is important to pay attention to the definitive diagnosis, class of antibiotic, dose, interval, route of administration, and exact duration of use.

Discussion: The World Health Organization (WHO) categorizes antibiotics into three groups: Access, Watch, and Reserve—known as the AWaRe classification—to help guide appropriate usage and combat antibiotic resistance. The Gyssens flowchart serves as a valuable tool for clinicians to qualitatively evaluate antibiotic utilization. In skin and soft tissue infections (SSTIs), treatment strategies are tailored according to the characteristics of the infection, including purulence, necrosis, and overall severity. …

Evidence-Based Strategies To Improve Retention Among Nurses In A Health Care Setting, Lilian Adamu

Walden Dissertations and Doctoral Studies

Retaining nurses is an ongoing challenge in the field of health care settings, particularly in health care environments. Because of the scarcity of nurses, health care agencies have depended on temporary and part-time nurses under short-term agreements, leading to heightened levels of stress and burnout, higher rates of employee turnover, reduced nursing income, and greater costs for the agency. The project site recognized nursing burnout and its issues, and nurse retention efforts shifted their focus to reducing burnout and stress among nurses. The literature findings emphasized the adverse effects of nurse burnout and stress in health care agencies and advocated …

Predictors Of Reported Serious Health Outcomes And Death A After Covid-19 Vaccine In The United States, Jean Amost Cadet

Walden Dissertations and Doctoral Studies

COVID-19 vaccines have been available in the United States since December 2020. However, very few studies have looked at the serious health outcomes reported by those who received a COVID-19 vaccine. Guided by the social ecological model, factors associated with reported serious health outcomes and deaths within the first 2 months after taking a COVID-19 vaccine were examined. A total of 720,210 cases from the U.S. Vaccine Adverse Event Reporting System data from December 2020 to December 2022 were analyzed using multiple logistic regression and multinomial logistic regression to determine if medical conditions predict the number of reported deaths and …

Social Worker Experiences Providing Mental Health Therapy To Iowa Lgbtq+ Youth, Kathy Jochims

Walden Dissertations and Doctoral Studies

High rates of untreated mental health issues and suicidality among LGBTQ+ youth, exacerbated by isolation and rejection in rural areas, demonstrate an urgent necessity for preventive and responsive mental health care. However, access to these essential services remains limited in many rural areas. This study involved using a generic qualitative design to explore the experiences of social workers providing mental health therapy to LGBTQ+ youth in rural Iowa, and presence of cultural humility in social worker practices. The cultural humility theory was chosen as the theoretical framework. Semistructured interviews with 10 Iowa social workers were evaluated using thematic analysis. Study …

Special Education Teachers’ Perceptions Regarding The Inclusion Of Students With Learning Disabilities In Assistive Technology, George Edward Avent

Walden Dissertations and Doctoral Studies

Special education teachers do not always include assistive technology (AT) in instructional practices to promote the academic success of students with learning disabilities. The purpose of this study was to explore the reasons special education teachers only sometimes include the use of AT in instructional practices. The conceptual framework was observational learning theory, also known as social learning theory, which focuses on human learning patterns based on observations of other human beings. A basic qualitative design with open-ended, semistructured interviews was used. The participants included 12 special education teachers from the school study site. The research questions framed the study’s …

Kenyon Collegian - December 12, 2024

The Kenyon Collegian

No abstract provided.

Novel Spatial Approaches To Dissect The Lung Cancer Immune Microenvironment, Idania Lubo, Sharia Hernandez, Ignacio I Wistuba, Luisa Maren Solis Soto

Faculty, Staff and Student Publications

Lung cancer is a deadly disease with the highest rates of mortality. Over recent decades, a better understanding of the biological mechanisms implicated in its pathogenesis has led to the development of targeted therapies and immunotherapy, resulting in improvements in patient outcomes. To better understand lung cancer tumor biology and advance towards precision oncology, a comprehensive tumor profile is necessary. In recent years, novel in situ spatial multiomics approaches have emerged offering a more detailed view of the spatial location of tumor and tumor microenvironment cells, identifying their unique composition and functional status. In this sense, novel multiomics platforms have …

Design, Synthesis, And Nmr-Guided Characterization Of A Targeted Covalent Inhibitor-Like Molecule Against Ivyp1 From P. Aeruginosa, Samuel Taylor Moore

Master's Theses

Multi-drug resistance poses a serious threat to future generations and historical antibiotic pipelines; consequently, the medical and economic burdens associated with treating multidrug-resistant bacteria are substantiated. In this context, P. aeruginosa (PA) emerges as one of the most significant healthcare challenges, being a leading cause of resistance-associated mortality worldwide. Despite modern efforts to combat these poor outcomes, drug-resistant cases continue to rise, and the need for novel antibiotic treatment is apparent. To this end, we investigated relevant resistance mechanisms and past antibiotic targets within PA, and in doing so, we identified relationships between peptidoglycan biology and a periplasmic protein, Inhibitor …

Review – Insect Farming For Food And Feed In The Global South: Focus On Black Soldier Fly Production, K. B. Barragán-Fonseca, D. Gómez, C. H. Lalander, D. Dzepe, S. Y. Chia

All Peer-Reviewed Publications

Clear differences exist between the Global South and the Global North with respect to economic development. The majority of small and medium-sized insect production farms are located in Africa, Asia, and Latin America, which face challenges to food production and organic waste management in general. These regions have a long history of insect use, as well as environmental advantages, making production of insects in general - and the black soldier fly in particular - a promising option for sustainable food production and organic waste management. This study aimed to identify the current state of black soldier fly (Hermetia illucens L.) …

Sel For Well-Being And Equity In Higher Education, Colleen Conley, Deborah Donahue-Keegan

Psychology: Faculty Publications and Other Works

The understood overarching purpose of higher education is to prepare students, typically young adults, with the knowledge and skills needed to navigate, thrive in, and be contributing members of society (Hurtado, 2019). In this time of unprecedented cross-sectoral complexity and volatility on a global scale, institutions of higher education must consider a more expansive set of learning and competency outcomes (Gopalan et al., 2022). This paradigm shift is essential given the alarming rise in mental health challenges on college and university campuses, deep polarization, and an increased demand for prosocial skills in workplaces across sectors (Dermody et al., 2022; Padurean …

Increasing Documentation Compliance Of The Bedside Mobility Assessment Tool, Eric Jiang

Master's Projects and Capstones

Objective: The objective of the quality improvement project is to increase documentation compliance and assessments of the Bedside Mobility Assessment Tool (BMAT) to help promote positive health outcomes and increase early mobility, while reducing the over utilization of physical therapy (PT). This can help reduce costs from potential health complications. Aim: The goal is to increase the utilization of the BMAT by 10% from 31.3% to 41.3% across three medical-surgical units from October 9, 2024 to November 22, 2024. Methods: To increase compliance with using the BMAT at the hospital, staff education was delivered through announcements, poster boards, and reminder …

Preoperative Detection Of Extraprostatic Tumor Extension In Patients With Primary Prostate Cancer Utilizing [68ga]Ga-Psma-11 Pet/Mri, Clemens P Spielvogel, Jing Ning, Kilian Kluge, David Haberl, Gabriel Wasinger, Josef Yu, Holger Einspieler, Laszlo Papp, Bernhard Grubmüller, Shahrokh F Shariat, Pascal A T Baltzer, Paola Clauser, Markus Hartenbach, Lukas Kenner, Marcus Hacker, Alexander R Haug, Sazan Rasul

Faculty, Staff and Student Publications

Objectives: Radical prostatectomy (RP) is a common intervention in patients with localized prostate cancer (PCa), with nerve-sparing RP recommended to reduce adverse effects on patient quality of life. Accurate pre-operative detection of extraprostatic extension (EPE) remains challenging, often leading to the application of suboptimal treatment. The aim of this study was to enhance pre-operative EPE detection through multimodal data integration using explainable machine learning (ML).

Methods: Patients with newly diagnosed PCa who underwent [68Ga]Ga-PSMA-11 PET/MRI and subsequent RP were recruited retrospectively from two time ranges for training, cross-validation, and independent validation. The presence of EPE was measured from post-surgical histopathology …

The 2024 Nobel Prize In Physiology Or Medicine: Microrna Takes Center Stage, George A Calin, Florent Hubé, Michael R Ladomery, Nicholas Delihas, Manuela Ferracin, Laura Poliseno, Luca Agnelli, Suresh K Alahari, Ai-Ming Yu, Xiao-Bo Zhong

Faculty, Staff and Student Publications

The Non-coding Journal Editorial Board Members would like to congratulate Victor Ambros and Gary Ruvkun, who were jointly awarded the 2024 Nobel Prize in Physiology or Medicine for their groundbreaking discovery of microRNAs and the role of microRNAs in post-transcriptional gene regulation, uncovering a previously unknown layer of gene control in eukaryotes [...].

Data Intensive Method For Processing Defect Detection And Mitigation For Composites, Deepak Kumar

Doctoral Dissertations and Master's Theses

Composite manufacturing without processing defects is a crucial step in satisfying the production, performance, and quality requirements of composite materials in various industries. Autoclave processing enables manufacturing of high-quality composite parts with excellent mechanical properties, whereas additive manufacturing (AM) offers adaptability to complex designs and streamlined processes. However, each method presents unique challenges; despite the benefits, autoclave processes can still result in processing defects, and AM is particularly susceptible to processing anomalies owing to the novelty of the process. Ensuring the quality and reliability of composite manufacturing is essential to fully capitalize on the advantages offered by both techniques. Artificial …

Adjustment To College Following The Covid-19 Pandemic, Neco Xyavier Johnson

Arts & Sciences Graduate Student Theses and Dissertations

ABSTRACT OF THE DISSERTATION Adjustment to College following the COVID-19 Pandemic Objective: The present study examined the relationship between college adjustment and individual differences following the COVID-19 pandemic. It compared the adjustment of students who attended college pre-pandemic (2019) and post-pandemic (2022) and investigated the role of individual difference variables in this adjustment. Method: The study involved 118 pre-pandemic and 250 post-pandemic first-time college students. Both cohorts’ adjustment was assessed at the end of their first semester. The post-pandemic cohort was also evaluated on individual difference measures like loneliness, personality, and emotion regulation. Results: Post-pandemic students exhibited poorer adjustment compared …

Acquisition Of English By Additional Language Learners In Inquiry-Based Classrooms Within International Baccalaureate Primary Years Program Schools, Valerian Goguadze

Dissertations

Many International Baccalaureate (IB) Primary Years Programme (PYP) schools provide English instruction to all students. The program has grown worldwide with a significant enrollment of students who speak a first language other than English, necessitating the need for an English as an Additional Language (EAL) curriculum. The IB’s philosophy of language acquisition is deeply integrated into its documents, school policies, and classroom practices. Consequently, all IB teachers, not just those who teach additional languages, are expected to have a basic understanding of how to teach English. Despite IB’s supportive-inclusive policies, EAL learners continue to face challenges in learning English.

There …

Re: Silver Bow Creek Butte Area Npl Site 3rd Quarter 2024 Butte Priority Soils Operable Unit Interim Site-Wide Surface Water Monitoring Data Report. Consent Decree- Civil Action No. Cv 89- 039-Bu-She, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Silver Bow Creek Butte Area Npl Site Spring Semi-Annual 2024 Butte Priority Soils Operable Unit Interim Site-Wide Groundwater Monitoring Data Report. Consent Decree- Civil Action No. Cv 89-039-Bu-She, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Blacktail Creek Groundwater Hydraulic Control System Pre-Design Investigation Evaluation Report (Dated September 16, 2024), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

New Species And Records Expand The Checklist Of Cellular Slime Molds (Dictyostelids) In Jilin Province, China, Zhaojuan Zhang, Liang He, Yuqin Sun, Zhuang Li, Yingqun Yang, Chao Zhai, Steven Lee Stephenson, Xiangrui Xie, Yu Li, Pu Liu

Biological Sciences Faculty Publications and Presentations

Dictyostelids represent a crucial element in the protist community, and their abundant presence in Jilin Province underscores their indispensable role in biodiversity conservation. In the present study, a resource survey of dictyostelids used random sampling to collect 28 soil samples from five localities in Changbai Korean Autonomous County, Jilin Province. In addition, a compilation of dictyostelid species reported from Jilin Province was developed, based on a thorough review of the literature. The survey yielded fifteen isolates of dictyostelids, comprising six species from four genera. Notably, two new species (Dictyostelium longigracilis sp. nov. and Dictyostelium macrosoriobrevipes sp. nov.) were described using …

Business Governance Strategies Needed To Reduce Corruption, Colin Milverton Jackson

Walden Dissertations and Doctoral Studies

Corruption undermines businesses by distorting competition, reducing performance, and hindering economic growth. Business leaders must understand and implement strategies to address fraud and corruption in order to ensure long-term success, benefiting both their companies and the broader economy. Grounded in stewardship theory, the purpose of this multiple case study was to explore strategies that small manufacturing business leaders use to implement business governance guidelines needed to reduce corruption in international transactions. Data were collected through semistructured face-to-face interviews and a review of company documents. he participants in this study were five business leaders from two firms who implemented successful strategies …

Business Governance Strategies Needed To Reduce Corruption, Colin Milverton Jackson

Walden Dissertations and Doctoral Studies

Corruption undermines businesses by distorting competition, reducing performance, and hindering economic growth. Business leaders must understand and implement strategies to address fraud and corruption in order to ensure long-term success, benefiting both their companies and the broader economy. Grounded in stewardship theory, the purpose of this multiple case study was to explore strategies that small manufacturing business leaders use to implement business governance guidelines needed to reduce corruption in international transactions. Data were collected through semistructured face-to-face interviews and a review of company documents. he participants in this study were five business leaders from two firms who implemented successful strategies …

School Principals’ Perception On Their Job Satisfaction, Arti Narayan

Walden Dissertations and Doctoral Studies

The school principal’s roles have become quite complex and strenuous causing an impact on school principals’ job satisfaction. The problem that was addressed through this basic qualitative study was the low job satisfaction of school principals at a school district in California. The framework used for the study was the job demands and resource theory. The purpose of this research study was to examine the perceptions of TK-12 school principals regarding their job satisfaction based on the job demands and resource framework. Using a basic qualitative research design, data were gathered through semistructured interviews with nine school principals out of …

A Potent Pan-Sarbecovirus Neutralizing Antibody Resilient To Epitope Diversification, Laura E Rosen, Zhuoming Liu, Sean P J Whelan, Et Al.

2020-Current year OA Pubs

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution has resulted in viral escape from clinically authorized monoclonal antibodies (mAbs), creating a need for mAbs that are resilient to epitope diversification. Broadly neutralizing coronavirus mAbs that are sufficiently potent for clinical development and retain activity despite viral evolution remain elusive. We identified a human mAb, designated VIR-7229, which targets the viral receptor-binding motif (RBM) with unprecedented cross-reactivity to all sarbecovirus clades, including non-ACE2-utilizing bat sarbecoviruses, while potently neutralizing SARS-CoV-2 variants since 2019, including the recent EG.5, BA.2.86, and JN.1. VIR-7229 tolerates extraordinary epitope variability, partly attributed to its high binding affinity, …

Genomic Surveillance Of Sars-Cov-2 In Nepal, Binod Khadka, Kathie A Mihindukulasuriya, Lindsay Droit, Anne M Paredes, Scott A Handley, David Wang, Et Al.

2020-Current year OA Pubs

During the COVID-19 pandemic, Nepal, like other countries, faced emerging SARS-CoV-2 variants. To evaluate the circulating variants, 278 samples collected between September 2021 and March 2022 were sequenced in the country. From these, 229 high-quality genomes were obtained (82.97% Omicron and 17.03% Delta) highlighting the genomic diversity of SARS-CoV-2 in Nepal.

Economic Evaluation Of A Community Dental Care Model For People Experiencing Homelessness, Tan Minh Nguyen, Robert Witton, Lyndsey Withers, Martha Paisi

Peninsula Dental School

Aim The study aims to conduct economic evaluation of the Peninsula Dental Social Enterprise (PDSE) programme for people experiencing homelessness over an 18-month period, when compared to a hypothetical base-case scenario (‘status quo'). Methods A decision tree model was generated in TreeAge Pro Healthcare 2024. Benefit-cost analysis and cost-effectiveness analysis were performed using data informed by the literature and probabilistic sensitivity analysis (Monte Carlo simulation with 1,000 cycles). The pre-determined willingness-to-pay threshold was estimated to be £59,502 per disability-adjusted life year (DALY) averted. Costs (£) and benefits were valued in 2020 prices. Health benefits in DALYs included dental treatment for …

Climbing The Not-For-Profit Leadership Ladder In Australia: Equity, Diversity, And Inclusion, Cheng Yen Loo, Shajimon Peter, Ian Moore, Michael Grove, Loretta Baldassar

Research outputs 2022 to 2026

This qualitative study examines equity, diversity, and inclusion (EDI) in the leadership roles of not-for-profit organizations (NPOs) where a significant number of social workers engage in professional practice. Two focus groups—one with members of the senior management of NPOs (n = 5) and another with emerging (aspiring and less experienced) leaders of NPOs (n = 6)—were conducted to gather perspectives and opinions on EDI in their organizations’ leadership roles. Four major themes emerged from the findings for promoting EDI, which include a whole of organization commitment, multilevel consideration with recruitment, mentorship, training, and advisory board as an untapped potential. Recommendations …

A Conjugate Of An Egfr-Binding Peptide And Doxorubicin Shows Selective Toxicity To Triple-Negative Breast Cancer Cells, Phi-Phung Than, Shih-Jing Yao, Emad Althagafi, Kamaljit Kaur

Pharmacy Faculty Articles and Research

Selective targeting of cancer cells via overexpressed cell-surface receptors is a promising strategy to enhance chemotherapy efficacy and minimize off-target side effects. In this study, we designed peptide 31 (YHWYGYTPERVI) to target the overexpressed epidermal growth factor receptor (EGFR) in triple-negative breast cancer (TNBC) cells. Peptide 31 is internalized by TNBC cells through EGFR-mediated endocytosis and shares sequence and structural similarities with human EGF (hEGF), a natural EGFR ligand. Unlike hEGF, peptide 31 does not induce cell migration in TNBC cells. A novel conjugate of peptide 31 with doxorubicin (Dox) retains selectivity for TNBC cells and exhibits significant toxicity comparable …

Firsthand Versus ‘Secondhand’ Perspectives Of Harm: Emphasising Teens’ Firsthand Perspectives Of Online Sexual Content, Harrison W. See, Giselle Woodley

Research outputs 2022 to 2026

This article examines interview data from 24 Australian families, exploring how teens express perceived harms associated with online Sexually Explicit Material (SEM). For many teens, an encounter with SEM occurs prior to their first partnered sexual experience, often before their first kiss (Crabbe et al. 1; Power et al. 11; Woodley et al., Teen Perspectives 2). Of relevance was how teens expressed the potential harms of online SEM. Specifically, this article examines the difference between instances of teens expressing perceptions of SEM via the perspectives of others (secondhand perspectives) in contrast with instances of teens citing their own encounters with …

Ire1Α Silences Dsrna To Prevent Taxane-Induced Pyroptosis In Triple-Negative Breast Cancer, Longyong Xu, Fanglue Peng, Qin Luo, Yao Ding, Fei Yuan, Liting Zheng, Wei He, Sophie S Zhang, Xin Fu, Jin Liu, Ayse Sena Mutlu, Shuyue Wang, Ralf Bernd Nehring, Xingyu Li, Qianzi Tang, Catherine Li, Xiangdong Lv, Lacey E Dobrolecki, Weijie Zhang, Dong Han, Na Zhao, Eric Jaehnig, Jingyi Wang, Weiche Wu, Davis A Graham, Yumei Li, Rui Chen, Weiyi Peng, Yiwen Chen, Andre Catic, Zhibin Zhang, Bing Zhang, Anthony M Mustoe, Albert C Koong, George Miles, Michael T Lewis, Meng C Wang, Susan M Rosenberg, Bert W O'Malley, Thomas F Westbrook, Han Xu, Xiang H-F Zhang, C Kent Osborne, Jin Billy Li, Matthew J Ellis, Mothaffar F Rimawi, Jeffrey M Rosen, Xi Chen

Faculty, Staff and Students Publications

Chemotherapy is often combined with immune checkpoint inhibitor (ICI) to enhance immunotherapy responses. Despite the approval of chemo-immunotherapy in multiple human cancers, many immunologically cold tumors remain unresponsive. The mechanisms determining the immunogenicity of chemotherapy are elusive. Here, we identify the ER stress sensor IRE1α as a critical checkpoint that restricts the immunostimulatory effects of taxane-chemotherapy and prevents the innate immune recognition of immunologically cold triple-negative breast cancer (TNBC). IRE1α RNase silences taxane-induced dsRNA through RIDD (Regulated IRE1-Dependent Decay) to prevent NLRP3 inflammasome–dependent pyroptosis. Inhibition of IRE1α in Trp53−/− TNBC allows taxane to induce extensive dsRNAs that are sensed …