Digital Commons Network^™

Changes In Reproductive Health Information-Seeking Behaviors After The Dobbs Decision: Systematic Search Of The Wikimedia Database, Mackenzie Lemieux, Cyrus Zhou, Caroline Cary, Jeannie Kelly

2020-Current year OA Pubs

BACKGROUND: After the US Supreme Court overturned Roe v. Wade, confusion followed regarding the legality of abortion in different states across the country. Recent studies found increased Google searches for abortion-related terms in restricted states after the Dobbsv. Jackson Women's Health Organization decision was leaked. As patients and providers use Wikipedia (Wikimedia Foundation) as a predominant medical information source, we hypothesized that changes in reproductive health information-seeking behavior could be better understood by examining Wikipedia article traffic.

OBJECTIVE: This study aimed to examine trends in Wikipedia usage for abortion and contraception information before and after the Dobbs decision.

METHODS: Page …

First-In-Human Dose-Escalation Study Of Fianlimab, An Antilymphocyte Activation Gene-3 Antibody, With Cemiplimab In Patients With Advanced Malignancies, Nehal J Lakhani, Haeseong Park, Et Al.

2020-Current year OA Pubs

PURPOSE: Preclinical data indicate that fianlimab (antilymphocyte activation gene-3) plus cemiplimab (anti-PD-1) enhances antitumor activity. Here, we report prespecified final analyses of the dose-escalation part of a first-in-human, phase 1 study (NCT03005782) of fianlimab as monotherapy and in combination with cemiplimab in patients with advanced malignancies.

PATIENTS AND METHODS: Adult patients received 1 to 40 mg/kg of fianlimab plus 350 mg of cemiplimab every 3 weeks (Q3W) across various dose-escalation schedules. Primary objectives were the rate of dose-limiting toxicities, adverse events (including immune mediated), deaths, laboratory abnormalities, and pharmacokinetics. Secondary outcomes were objective response rate, best overall response, duration of …

"He Calls His Dada Still": Nineteenth-Century English Radicalism And The Drama Of Pádraic Pearse, James Moran

Kritika Kultura

This essay explores the extent to which some of the political upheavals of twentieth-century Ireland, and their related theatrical manifestations, might reveal a series of affinities with the organised political radicalism of nineteenth-century England. Specifically, the playhouse dramas written by the executed leader of the Easter Rising of 1916, Pádraic Pearse (also known as Pádraig or Patrick) point back to the earlier Liberal reform meetings that took place in the English midlands. The key connecting figure is the revolutionary leader’s father, James Pearse, who spent his life between Birmingham and Dublin, but who has tended to be overlooked by historians …

Poems, Mary Kennan Herbert

Kritika Kultura

No abstract provided.

American Globality And The Us Prison Regime: State Violence And White Supremacy From Abu Ghraib To Stockton To Bagong Diwa, Dylan Rodriguez

Kritika Kultura

What do we make of the abiding significance of state-sanctioned human captivity and imprisonment on a massive, unprecedented scale as a primary American modality of civilization? Democracy? Modernity and (postmodern) Nation-building? The American prison intertwines as it animates two structural logics: 1) white supremacy as a historical modality of social (dis)organization, and 2) the circulation, militarization, and mobilization of allegedly local or domestic US social formations across global geographies, including and beyond the Philippines. This paper considers the formation of the United States prison industrial complex as an epochal global regime that is integral to the fabric of an incipient …

The Communality Of Creativity And The Creativity Of Community: A Comparison Of The Ethics Of Nikolai Berdyaev And Watsuji Tetsurō, Anton Luis Sevilla

Kritika Kultura

Self-fidelity is a human ethical task. But how can we be faithful to a self that is both individual and social? This paper takes up this question by comparing the basic ethical frameworks of Nikolai Berdyaev and Watsuji Tetsurō. In the first section of this paper, Berdyaev’s notion of personality and his three forms of ethics (ethics of law, ethics of redemption, and ethics of creativeness) are discussed. In the second section, Watsuji’s notion of ethics as the study of man (ningen) is explored, detailing the dual structure of ningen and the double-negation of ethics. And in the third section, …

"At A Loss For Words": Theatre, Performance And The Northern Ireland Prison Protests, Lionel Pilkington

Kritika Kultura

In plays as diverse as Brian Friel’s The Freedom of the City, Frank McGuinness’s Carthaginians and Vincent Woods’s At the Black Pig’s Dyke, there is evidence of an intemperate opposition to the idea of republicans performing protest against the state in Northern Ireland. Using Augusto Boal’s conception of theatre as a cultural weapon with a powerful emancipatory and utopian potential (“theatre as a rehearsal for revolution”) and drawing on Joseph Roach and Nicholas Argenti’s ideas of the kinesthetic imagination, this essay considers the republican prison protests that took place Ireland in the period 1978-81. “At a Loss for Words” argues …

"To Speak Your Truth": Dialogues On Political Theatre And The Troubles, Bill Mcdonell, Joe Reid

Kritika Kultura

This essay is structured in two sections: At the outset, Bill McDonnell provides an overview of the broader political and cultural context which produced Belfast Community Theatre, and other significant grass-roots Republican community theatres from the 1970s. Together, and especially in the case of Republican theatre groups, the essay argues that they constitute the only radical theatres in post-1945 Britain and Ireland to meet Erwin Piscator’s stringent criteria for a political theatre. This is followed by a series of dialogues on theatre and the war in the north of Ireland, which take up the larger part of the essay. The …

Fostering Conceptual Roles For Change: Identity And Agency In Esea Teacher Preparation, Brian Morgan

Kritika Kultura

English Changing, the theme and title of the 2009 ESEA conference held in Manila, raises specific challenges for language teacher education: To what extent do we prepare teachers to be passive recipients of the social, cultural, and economic changes that align with the global spread of English? Alternatively, how might we encourage teachers to become active participants—“agents of change”—through their mediation and implementation of language curricula and pedagogy? The author addresses such questions by first reflecting on his own personal and professional development in EFL and EAP teaching contexts. These experiences are then related to the growing research literature in …

Universal Basic Income Policy And Its Potential Impact On Welfare Reform, Adriana S. Hines, Lindsay Gietzen

Pacific Journal of Health

This systematic review synthesizes the current Universal Basic Income (UBI) research. As income inequality continues to affect health outcomes, UBI has been proposed as a strategy to reduce gaps in healthcare access, food security, housing, and overall well-being. The review examines 12 peer-reviewed articles to understand how UBI can impact the direct and indirect factors contributing to the disparities that the current welfare system may not adequately address. The findings indicate that UBI can help alleviate poverty-related stress, potentially leading to better mental and physical health outcomes through improved nutrition, more stable housing, and greater life satisfaction. Additionally, UBI has …

Preparing Spiritually Resilient Warriors In The Canadian Special Operations Forces Command, Vic Morris

Doctor of Ministry Major Applied Project

Morris, Victor E. “Preparing Spiritually Resilient Warriors in the Canadian Special Operations Forces Command.” Doctor of Ministry. Major Applied Project, Concordia Seminary, 2024. 285 pp.

The Canadian Armed Forces has outcomes and expectations for warriors to be spiritually resilient but does not have a training program that has been researched, tested, and validated to achieve this. This study investigates how chaplains can prepare spiritually resilient warriors in CANSOFCOM. A chaplain-led spiritual resilience course was created and delivered to CANSOFCOM members. The course was aligned with the holistic wellness strategy of OPF2, and designed as an inductive, experiential learning experience. An …

Horticulture Interventions Impact On Eating Disorder Symptoms, Taylor Kline

Counselor Education Capstones

Nature-based counseling offers a wide variety of options that counselors could incorporate into their session as a complementary form of counseling paired with another theory. Specifically, horticulture interventions have been found to increase clients’ self-efficacy and self-esteem, as well as reduce anxiety, which are all common symptoms of eating disorders. With the lack of research on horticulture interventions and the idea of utilizing them within the treatment of eating disorders, the contents of this paper aim to point out the variety of benefits of said interventions on common symptoms that are often related to eating disorders. Future research should focus …

Navigating Caregiving: Community Resources And Support Systems For Individuals With Severe Mental Illness Living With Aging Parents, Adam Thai

DNP Qualifying Manuscripts

People with severe mental illness (SMI) who are cared for by aging parents are a growing concern within the community, due to their potential high utilization on healthcare facilities and community infrastructure. Many utilize hospitals and emergency departments to seek behavioral, social, and housing support instead of outpatient behavioral healthcare. There is a disconnect in finding social support that is a result of learned reliance and dependence on their aging parents for financial and caregiving support. Healthcare providers should be mindful of the long-term issues this population faces once they are without parental support, such as increased risks for criminality …

The Burden Mothers Bear: Using The Health Belief Model To Understand How U.S. Mothers’ Intersectional Identities Shape Health Decision-Making During Covid-19, Sydney O'Shay, Kaitlin E. Phillips, Marissa J. Sáez

Publications

The disproportionate impact of COVID-19 on people of color and the burden placed on mothers created a need to better understand how mothers of color made health decisions for their families and communicated these decisions with others during the pandemic. This study investigated how this populations’ intersectional identities played a role in their health decision-making processes and overall experiences during COVID-19. Using the health belief model as a sensitizing concept, we conducted qualitative in-depth interviews with mothers of color across the United States about their lived experiences during the pandemic. Our findings suggest a need for health communicators to address …

Influence Of Internalizing And Externalizing Traits On Cognitive Performance In Typically Developing Children, Carlie Sivils

Psychology ETDs

This study investigates the relationship between emotional traits—internalizing (INT) and externalizing (EXT) subclinical characteristics—and cognitive performance in typically developing children (TDC). INT and EXT measures from the Strengths and Difficulties Questionnaire (SDQ) and cognitive task performance in various cognitive domains, including in verbal comprehension, perceptual reasoning, memory, and cognitive inhibitory control, using standardized neuropsychological test battery (NIH Toolbox, WASI) were examined. Regression analyses, ordinary least squares and robust regression models, were used to explore associations between INT and EXT traits and cognitive task performance, controlling demographic factors such as gender, socioeconomic status (SES), and ethnicity. Results indicate INT and EXT …

Coastal Marine Heatwaves In The Santa Barbara Channel: Decadal Trends And Ecological Implications, Kit Yu Karen Chan, L. Kui, A. M. Mcdonald, A. L. Ritger, G. E. Hofmann

Biology Faculty Works

Marine heatwaves (MHWs) are of increasing concern due to the emerging ecological and socioeconomic impacts on coastal ecosystems. Leveraging the data of the Santa Barbara Coastal Long-Term Ecological Research project, we analyzed the MHW event metrics observed in the kelp forest ecosystem and across Santa Barbara Channel, CA, USA. Not only was there a significant positive trend in the number of MHWs recorded, their duration and intensity were also increasing over time. MHWs were detected year-round, suggesting that marine organisms have exposure risks regardless of their phenology. Exposure at one life history stage could have a legacy effect on the …

Trade Openness, Human Capital, And Economic Resilience In Saarc Countries: A Post-Covid-19 Analysis, Sumra Khalid, Khalid Mahmood Mughal, Bushra F. Malik

Accounting, Business Analytics, Economics, and Finance Department Faculty Articles

The present study analyzes the interrelationship between trade openness, labor force participation, human capital, and economic growth in the SAARC countries, with particular attention to the implications of the COVID-19 pandemic on these linkages. In this paper, an attempt has been made to gauge both the short-run and long-run impacts that have resulted in the facilitation of economic growth through trade openness by increased market access, technology transfers, and competitive efficiency. However, the pandemic distorted trade flows and lost labor to more labor-intensive industries, generally hitting the low-income and marginal groups harder while underlining vulnerabilities in the trade-dependent economies. These …

Tnf Prevents Establishment Of Anti-Tumor Immunity And Elucidates Toxicities Following Myxoma Virus Based Oncolytic Virotherapy, Miriam Beatriz Valenzuela Cardenas

Biomedical Sciences ETDs

Tumor Necrosis Factor Alpha (TNF) can lead to tumor regression through its direct cytolytic activity, yet it has also been implicated to facilitate tumor progression. This scenario complicates the efficacy and applicability of TNF based therapeutics as treatment for malignancies. In the context of oncolytic virotherapy (OV) which uses replicating viruses to treat tumors and acts by triggering production of pro-inflammatory cytokines, exploring such mechanisms is vital. Here we show that a Myxoma based oncolytic virus (vPD1/IL12) can induce large amounts TNF. The presence of TNF in the context of vPD1/IL12 plays a detrimental role both for tumor regression by …

Investigating Tumor Growth And Regulation In Supratentorial Ependymomas; The Impact Of Dlk1 And Egr1 Knockout, Om Sinojia

Honors Scholar Theses

Ependymomas (EPNs) are primary brain tumors that often arise from radial glial cells lining the ventricular system. Supratentorial ependymomas (ST-EPNs) are particularly aggressive, and understanding the molecular factors driving their growth is critical for developing targeted therapies. This study investigates the roles of DLK1 and EGR1, key regulators in cellular differentiation and tumorigenesis, in the development of ST-EPNs. We utilized genetically engineered mouse models to induce postnatal knockouts of DLK1 and EGR1 and evaluated tumor growth using histological and imaging techniques. Tumor area was quantified across multiple brain sections from both male and female mice. DLK1 knockout brains exhibited consistent …

5-Fluorouracil Induced Oxidative Stress Is Variable Across Triple Negative Breast Cancer Cell Lines, Rachel L. Walker

Departmental Honors & Graduate Capstone Projects

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with treatment limited to chemotherapy. However, not all patient tumors respond to chemotherapy. The variable cytotoxic effects of chemotherapies may be due to how cancer cells regulate reactive oxygen species (ROS). In this study, we examined two mouse breast cancer cell lines: 4T1 and EO771, vary when treated with hydrogen peroxide (H2O2) and 5-Fluorouracil (5FU), known ROS-inducing substances. In 4T1 cells H2O2 increased oxidized DNA but caused minimal cell death. While in EO771 cells that same amount of H2O2 caused complete apoptosis. Cell number, ROS, and cell death showed …

Evaluation Of Electrode Configurations For (0,2) Piezoelectric Ultrasound Transducers, Abdul Qayoum Popal

Mechanical Engineering ETDs

Piezoelectric micro ultrasound transducers (PMUT array) are pivotal in MEMS applications. They typically operate in the fundamental (0,1) acoustic mode and are not significantly researched for higher modes (0,2) and (0,3). Similarly, vibrating mesh atomizers (VMAs) demand the second (0,2) mode and third mode (0,3) for effective aerosol generation, highlighting the need for optimized electrode configurations—a relatively unexplored area. This study presents the first comprehensive analysis of how electrode designs influence PMUT performance in the (0,2) mode for VMA applications.

Utilizing COMSOL multiphysics finite element modeling (FEM) with residual stress considerations alongside experimental validation, we demonstrate that optimized electrode configurations …

Corneal Transplants And Their Impact, Bianca Estrada

Honors Capstones

A corneal transplant, also called keratoplasty or corneal grafting, is a type of surgery where damaged or diseased corneal tissue is replaced by a healthy donor cornea. The first successful corneal transplant was performed in 1905 by Dr. Eduard Zirm, but since then, surgical advancements have developed greatly, leading to more beneficial outcomes. Corneal blindness is a major form of reversible blindness that is manageable with healthy donor cornea transplantation. Other recipients or possible candidates for corneal transplantation include those with keratoconus, Fuchs’ dystrophy, eye infections, or eye injuries. This remarkable surgery is now one of the most common transplant …

Effects Of Modification In Limonene And Geraniol On The Properties Of Thermal Cured Polyurethane Films, Sauravkumar Rajeshbhai Patel

Electronic Theses & Dissertations

The increasing demand for green materials has inspired in-depth research into biobased polymers; among these polymers, polyurethanes stand out because of their widest range of applications: coatings, adhesives, and biomedical devices. The subject of this paper is the preparation of bio-based polyurethane films based on the polyols synthesized from renewable feedstocks such as limonene, geraniol, and soybean oil. Limonene and geraniol were chemically modified from natural sources such as citrus fruits and essential oils to high-functionality polyols. Characterization of such polyols showed that geraniol had the highest hydroxyl (OH) value and thus geraniol-based polyurethane films were highly influencing in reactivity …

3d Game: Enhancing Game Ai With Machine Learning, Nicholas William English

Masters Projects

Machine learning (ML) and artificial intelligence (AI) are terms that are often used synonymously, but they are ever-so slightly different. Machine learning is really a subset of artificial intelligence and involves creating an algorithm so that a computer can learn patterns. Artificial intelligence extends machine learning with the goal to go beyond pattern recognition by having a computer that is capable of mimicking human intelligence. Video games often use the term AI in reference to the bots or non-playable characters (NPCs) that players may interact with. Generally, these bots do not actually implement AI, nor do they use ML, but …

Decentralized And Divided: Philadelphia’S Public Assistance System And Community-Based Initiatives, Gianna Casey, Shari Orisich

Honors Theses

Public assistance programs and community-based initiatives have aided Philadelphian’s residents in a cohesive effort to fill the gaps of community-needs. While both are inherently different in their methodologies and executions, their structures are built upon a collective foundation of legislative principles and policy-based ordinances in Philadelphia. These concepts, first began with poor laws and religious organizations in the 19th century, have turned into a complex system that has fallen tremendously short of sufficiently addressing the specialized needs of Philadelphian families. The surrounding laws for public assistance program administration (e.g. TANF and WIC), are founded within the objectives of these poor …

Gad314.1 Portfolio Example 1, Sae University College

Exemplars

An example of GAD314.1 - Portfolio of high quality and work to serve as an exemplar for future trimesters.

Targeting Myeloid Cell Iron Metabolism In Salmonella-Induced Colitis, Mariella Arcos Padilla

Biomedical Engineering ETDs

Salmonellosis is a severe infection caused by Salmonella enterica serovar Typhimurium, leading to significant global morbidity and mortality.

Previous studies have shown that mice lacking the iron storage protein ferritin heavy chain (FTH1) in myeloid cells exhibit worsened Salmonella infection. Nuclear receptor co-activator 4 (NCOA4) directs FTH1 autophagic degradation to release iron from storage during conditions of low iron. However, the role of myeloid NCOA4 in regulating bacterial infections remains unclear.

Here, we found that myeloid NCOA4 deficiency augments spleen iron levels and increases cellular iron accumulation, oxidative stress, and ferroptosis in bone marrow-derived macrophages (BMDM) cells. This deficiency also …

Partisan Rhetoric And Polarization: The Year In C-Span Archives Research, Volume 10

The Year in C-SPAN Archives Research

Partisan Rhetoric and Polarization: The Year in C-SPAN Archives Research, Volume 10 features chapters written from a variety of perspectives that address divisions in American politics. The topics range widely, including TikTok, abortion, the middle class, the January 6 riot, and partisan rhetoric in Congress. The unifying theme of the volume is that each author uses C-SPAN videos to examine how members of Congress and other elites speak and act on these issues. Two other thoughtful pieces examine Supreme Court justices speaking off the bench and emotional reactions in presidential debates. Partisan Rhetoric and Polarization provides context to understand how …

New Trends In The Study Of Haredi Culture And Society, David N. Myers, Nechumi Malovicki-Yaffe

The Jewish Role in American Life: An Annual Review

Who are Haredim? And why are they the source of both increasing attention and continuing misunderstanding? New Trends in the Study of Haredi Culture and Society draws on the innovative research of leading scholars from a variety of disciplines—including history, religious studies, demography, linguistics, and geography—to trace the growing prominence of Haredi (often called ultra-Orthodox) Jews in Jewish life. Haredi Jews are committed to preserving a measure of segregation from the rest of society consistent with the guiding principles of their forebears; yet increasingly, they are appearing more visibly and assertively in public spaces. Demographic analysis suggests that they will …

Construction Site Planning And Logistical Operations: Site-Focused Management For Builders, Second Edition, Randy R. Rapp, Bradley L. Benhart

Purdue Handbooks in Building Construction

Organizing and administering a construction site so that the right resources get to the right place in a timely fashion demands strong leadership and a well-defined, disciplined process. Good logistical operations enable profitability, and this book is the essential, muddy boots guide to such management. Written by experienced educator–practitioners, Construction Site Planning and Logistical Operations is a popular guide to the knowledge, skills, and abilities needed by project superintendents, especially, but useful to all constructors. This second edition is updated to include new technologies, resources, and details of operational planning. Leadership imperatives and management techniques remain integrated throughout. The book …