Digital Commons Network^™

Head-To-Head Comparison Of Aptamer- And Antibody-Based Proteomic Platforms In Human Cerebrospinal Fluid Samples From A Real-World Memory Clinic Cohort, Raquel Puerta, Amanda Cano, Pablo García-González, Fernando García-Gutiérrez, Maria Capdevila, Itziar De Rojas, Clàudia Olivé, Josep Blázquez-Folch, Oscar Sotolongo-Grau, Andrea Miguel, Laura Montrreal, Pamela Martino-Adami, Asif Khan, Adelina Orellana, Yun Ju Sung, Ruth Frikke-Schmidt, Natalie Marchant, Jean Charles Lambert, Maitée Rosende-Roca, Montserrat Alegret, Maria Victoria Fernández, Marta Marquié, Sergi Valero, Lluís Tárraga, Carlos Cruchaga, Alfredo Ramírez, Mercè Boada, Bart Smets, Alfredo Cabrera-Socorro, Agustín Ruiz

Faculty, Staff and Student Publications

High-throughput proteomic platforms are crucial to identify novel Alzheimer’s disease (AD) biomarkers and pathways. In this study, we evaluated the reproducibility and reliability of aptamer-based (SomaScan® 7k) and antibody-based (Olink® Explore 3k) proteomic platforms in cerebrospinal fluid (CSF) samples from the Ace Alzheimer Center Barcelona real-world cohort. Intra- and inter-platform reproducibility were evaluated through correlations between two independent SomaScan® assays analyzing the same samples, and between SomaScan® and Olink® results. Association analyses were performed between proteomic measures, CSF biological traits, sample demographics, and AD endophenotypes. Our 12-category metric of reproducibility combining correlation analyses identified 2428 highly reproducible SomaScan CSF measures, …

The Reel Narrative: The Portrayal And Consequent Archetypes Of Women In Selected Mainstream Philippine Romantic Cinema, Ma. Beatrice P. Pilar, Nathaniel Rey D. Ferrer

Sinaya: A Philippine Journal for Senior High School Teachers and Students

In Philippine society, media, particularly romance films, shapes and reinforces audiences’ perspectives, perpetuating preconceived notions and stereotypical beliefs. However, there is a lack of textual analysis within Filipino films, especially regarding female representation in media. Hence, our study explores the portrayal of female main characters in romance films. Textual film analysis, grounded in Carl Jung’s Jungian archetypes and Jean Shinoda Bolen’s female archetypes in media, was implemented on the six Filipino highest-grossing romance films from 2014 until 2019. This analysis, further supported by a feminist lens, aimed to identify the character portrayal and archetypes of the main female characters in …

Gender Rebellion: Gender Non-Conformity As An Act Of Resistance In The Hunger Games, Julia Koncurat

Criterion: A Journal of Literary Criticism

No abstract provided.

“Whilst In The Walrus Suit, You Must Be A Walrus”: Human-To-Animal Transformation Through Body Modification And Performance In Kevin Smith’S Tusk, Ahmet Ergün

Criterion: A Journal of Literary Criticism

No abstract provided.

What Is Deeply Rooted In The Constitution?, Thomas P. Crocker

BYU Law Review

In a series of cases stretching over a century, the Court made a right’s roots a constitutive feature of its identity. Highlighting the analytic centrality of deep roots to the recognition of rights, Dobbs v. Jackson Women’s Health withdrew prior judicial recognition of a woman’s right to reproductive choice, arguing that such a right was not properly rooted in the American legal tradition. But what does it mean for a right to have deep roots? A surprising feature of American constitutionalism is that there is no single answer to the basic analytic question of what it means for a right …

“Whoever Invents Or Discovers”: Artificial Intelligence And The Case For Joint Inventorship, Seth F. Littleford

BYU Law Review

Artificial intelligence (AI) is increasingly important in the modern world. Given its fidelity to—and, in some cases, its surpassing of—human performance, people rely upon AI in myriad settings. The AI era is already here, and the technological advancements to come are even more mind-boggling. The United States Patent and Trademark Office (USPTO) has seen a significant increase in patent applications claiming inventions pertaining to AI, but how does the patent system handle when AI invents?

The U.S. Court of Appeals for the Federal Circuit recently held in Thaler v. Vidal that the Patent Act requires inventors listed on patent applications …

Biological Aging Pathways That Underlie Life Course Socioeconomic Disparities In Physical Function And Longevity, Tara Gruenewald, Naomi Podber

Psychology Faculty Articles and Research

The poorer functioning and greater morbidity and mortality risk in those with greater life course socioeconomic disadvantage has led to the search for the biological processes that underlie these associations, including accelerated cellular and system aging. Our study examines whether a DNA methylation profile of the pace of biological aging (DunedinPACE) and a multi-system index of physiological dysregulation (allostatic load (AL)) mediate associations between life course socioeconomic disadvantage (SESDIS) and both physical function (gait speed, chair stand time) and survival. Data are from the Midlife in the U.S. Study (N=1,295, age 26–86, 55.4% female, 69.0% white). Measures included a multi-indicator …

Linking Transcriptome And Morphology In Bone Cells At Cellular Resolution With Generative Ai, Lu Lu, Noriaki Ono, Joshua D Welch

Faculty, Staff and Student Publications

Recent advancements in deep learning (DL) have revolutionized the capability of artificial intelligence (AI) by enabling the analysis of large-scale, complex datasets that are difficult for humans to interpret. However, large amounts of high-quality data are required to train such generative AI models successfully. With the rapid commercialization of single-cell sequencing and spatial transcriptomics platforms, the field is increasingly producing large-scale datasets such as histological images, single-cell molecular data, and spatial transcriptomic data. These molecular and morphological datasets parallel the multimodal text and image data used to train highly successful generative AI models for natural language processing and computer vision. …

Exploratory Clinical Assessment And Treatment Of Autonomic Nervous System Dysregulation Post Concussion: A Case Study, Megan Coker, James May

Clinical Practice in Athletic Training

The physiological alterations in autonomic nervous system (ANS) function due to concussion are suggested to play a role in persistent post-concussion symptoms (PPCS). Currently, there are few objective and clinically feasible measurements to assess ANS vitality in patients experiencing PPCS. The following case study details an assessment and treatment protocol targeted towards regulating the ANS in an adolescent female suffering from PPCS one month after injury. Pre-intervention, patient-reported outcome measures (PROMs) used to assess perceived pain, anxiety, stress, and breathing function were administered as well as a physical assessment performed for breath function and vagus nerve integrity. The patient was …

Ai-Assisted Academia: Unveiling Doctoral Students' Perspectives On Dissertation In Practice Innovation, Jennifer J. Lesh, Jévaughn J. Lancaster

Faculty and Staff Publications & Presentations

This action research study explores 73 doctoral students' perceptions of using Generative Artificial Intelligence (GAI) throughout their research journey in one educational doctorate (Ed.D) program. The first phase employed surveys, while the second incorporated semi-structured focus group interviews based on the survey data from a diverse sample of students across educational disciplines currently enrolled in the university's educational leadership doctoral program. In the study's first phase, the survey quantified educators' familiarity with, attitudes towards, perceived challenges, ethical considerations, and benefits of using GAI in doctoral research. The exploration of GAI in this practitioner-inspired doctoral program has uncovered essential insights into …

“Religion’S Firm-Rooted Truths:” Richard Polwhele, Pulpit Oratory And Loyalist Romanticism In The English Province, Dafydd Moore

School of Law, Humanities and Social Sciences

This article explores the rearguard action fought by the clergyman and writer Richard Polwhele against what he saw as the threat of Anglican Evangelicalism and Methodism in Cornwall during the French Revolutionary period, highlighting the connections between religious experience, rhetorical performance and politics. Whether it be through his theorizing of pulpit oratory, his rows with those he considered Enthusiasts or his understanding of ordination oaths, Polwhele maintained that religious belief should be regulated by rhetorical distance. Explaining this stance, the article shows how Polwhele’s theological and ecclesiological opposition to the Enthusiasm he regarded as dangerously inherent in Evangelical Protestantism also …

Advancing Statistical Literacy In Eye Care: A Series For Enhanced Clinical Decision-Making: Part 1: Introduction To Statistical Tools For Eye Care Research, Daniela Oehring, Pedro Miguel Serra

School of Health Professions

Purpose. Advancements in eye and vision care hinge on therigorous application of research and the precise interpretationof clinical data. However, the field of Eye and Vision Research(EVR) frequently encounters research waste attributed tomethodological flaws and improper statistical analyses, un-dermining the validity of studies and inefficiently utilisingsubstantial financial resources. This paper, the first instalmentin the series “Advancing Statistical Literacy in Eye Care: A Se-ries for Enhanced Clinical Decision-Making,” aims to addressthese challenges by enhancing the statistical literacy of eyecare professionals.Material and Methods. Through a comprehensive narrativeliterature review and the generation of simulated clinicaldatasets, this study identifies essential statistical concepts,common pitfalls, and …

Implications Of Myocardial Strain In Primary Mitral Regurgitation-A Cardiovascular Magnetic Resonance Study, Simone Romano, Danai Kitkungvan, Duc T Nguyen, Carlos El-Tallawi, Edward A Graviss, Afshin Farzaneh-Far, Dipan J Shah

Faculty, Staff and Student Publications

Aims: Chronic primary mitral regurgitation (MR) results in progressive left ventricular (LV) remodelling. Abnormal myocardial deformation (strain) can be present despite preserved ejection fraction (EF). Cardiovascular magnetic resonance (CMR) feature-tracking techniques allow assessment of global longitudinal strain (GLS) from routine cine images. The aim of this study is to evaluate the prognostic value of CMR feature tracking-derived GLS in patients with primary MR.

Methods and results: Consecutive patients undergoing CMR for chronic MR from January 2012 to June 2018 were enrolled. Patients with LVEF < 50% were excluded. The composite primary outcome aiming to detect decompensation related to MR comprised (i) referral for mitral surgery owing to symptoms or LV systolic dysfunction or (ii) cardiovascular death. The secondary outcome was all-cause death. A total of 422 patients were followed for a median of 2.7 years, and the primary endpoint was met in 93 patients (34 patients reported symptoms at baseline). At multivariable analysis, GLS≥ -16.6% was associated with primary outcome [hazard ratio (HR) 1.90, P = 0.01]. In moderate MR cohort, patients with GLS≥ -16.6% had worse event-free survival, whereas there was no significant difference in mild or severe MR groups. GLS≥ -16.0% remained associated with all-cause death after adjusting for other covariates including the MR severity (HR 2.24, P = 0.02).

Conclusion: In patients with primary MR with preserved systolic function, GLS was associated with our composite …

Acute Myocarditis Secondary To Human Metapneumovirus: A Case Series And Mini-Review, Hussam Al Hennawi, Aamna Khan, Alexander Shpilman, Jennifer A. Mazzoni

Abington Jefferson Health Papers

Among viral myocarditis, human metapneumovirus (hMPV) is a rare causative agent with associated cardiac complications. This report provides insight into the disease progression and sheds light on reported cases from the literature. We present the clinical courses of two patients, aged 68 and 58, who developed myocarditis secondary to hMPV infection. Despite the typical severity associated with viral myocarditis in older populations, both patients experienced significant improvement in their condition and ultimately survived. This report highlights the necessity of recognizing hMPV as a potential cause of myocarditis, particularly in older adults presenting with simultaneous respiratory and cardiac symptoms. The recovery …

Decoding The Dynamics In Financial Fraud, Triana Eva Adiningsih

Jurnal Akuntansi dan Keuangan Indonesia

This empirical study examines fraud for the entire period and then compares it with the latest trends in the five years. This study utilizes extensive data sets to analyze specific aspects of fraud, including causes, types, solutions, and real-world cases. This study conducted a systematic literature review of relevant literature by taking data from Scopus-indexed journals. Vosviewer was used to identify events, and spreadsheet file information was grouped manually. Interestingly, the cheating types of ‘five-year statistics’ and ‘all-time statistics’ show slightly different frequencies. The main research topics focus on money laundering and financial crimes. To explore this further, this report …

Transcriptomic Profile Analysis Of Brain Tissue In The Absence Of Functional Trpm8 Calcium Channel, Erick B Saldes, Alexandra Erdmier, Jai Velpula, Timothy E Koeltzow, Michael X Zhu, Swapna Asuthkar

Faculty, Staff and Student Publications

Background/Objectives: Transient Receptor Potential Melastatin 8 (TRPM8) is a non-selective, Ca2+-permeable cation channel involved in thermoregulation and other physiological processes, such as basal tear secretion, cell differentiation, and insulin homeostasis. The activation and deactivation of TRPM8 occur through genetic modifications, channel interactions, and signaling cascades. Recent evidence suggests a significant role of TRPM8 in the hypothalamus and amygdala related to pain sensation and sexual behavior. Notably, TRPM8 has been implicated in neuropathic pain, migraines, and neurodegenerative diseases such as Parkinson's disease. Our laboratory has identified testosterone as a high-affinity ligand of TRPM8. TRPM8 deficiency appears to influence behavioral traits in …

Mathematical Modelling And Analysis For The Co-Infection Of Viral And Bacterial Diseases: A Systematic Review Protocol, Timothy Kiprono Yano, Ebenezer Afrifa-Yamoah, Julia Collins, Ute Mueller, Steven Richardson

Research outputs 2022 to 2026

Introduction Breaking the chain of transmission of an infectious disease pathogen is a major public health priority. The challenges of understanding, describing and predicting the transmission dynamics of infections have led to a wide range of mathematical, statistical and biological research problems. Advances in diagnostic laboratory procedures with the ability to test multiple pathogens simultaneously mean that co-infections are increasingly being detected, yet little is known about the impact of co-infections in shaping the course of an infection, infectivity, and pathogen replication rate. This is particularly true of the apparent synergistic effects of viral and bacterial co-infections, which present the …

Biostatistik In Ophthalmologie Und Optometrie: Eine Artikelserie Zur Unterstützung Evidenzbasierter Entscheidungsprozesse, Daniela Oehring, Pedro Miguel Serra

School of Health Professions

Zweck. Fortschritte in der Augen- und Sehversorgung basieren auf der Anwendung von Forschungsergebnissen und der präzisen Interpretation klinischer Daten. Dennoch treten in der Augen- und Sehforschung (EVR) häufig Forschungsverschwendungen auf, bedingt durch methodische Mängel und unangemessene statistische Analysen. Dies untergräbt die Validität von Studien und führt zu ineffizienter Nutzung erheblicher finanzieller Ressourcen. Dieser Artikel, der erste Teil der Serie „Entwicklung statistischer Kompetenzen in der Augenheilkunde: Eine Reihe zur Unterstützung evidenzbasierter Entscheidungsprozesse”, zielt darauf ab, diese Herausforderungen anzugehen, indem er die statistische Kompetenz von Fachkräften in der Augenheilkunde stärkt.Material und Methoden. Anhand einer umfassenden narrativen Literaturübersicht und der Erstellung simulierter klinischer …

Digital Inclusion - Establishing And Understanding The Problem In A Digital First Musculoskeletal Physiotherapy Service: A Practice Improvement Project, Andrew Deare

South West Clinical School Journal

#400WORDS: CHIEF NURSING OFFICER’S RESEARCH FELLOWS EVIDENCE IMPLEMENTATION PROJECTS

Research Focusing On Protective Factors: From Individual To Community And Societal Strengths, Maria Caridad H. Tarroja

Asia-Pacific Social Science Review

No abstract provided.

“The People Deserve Better Governance”: Examining The Letters Of Filipino High School Students To The Next President Of The Philippines, Ma. Glenda Lopez Wui, Jessica Sandra R. Claudio, Rosselle Trishia M. Reyes, Carl Russel R. Reyes, Jie Zhang, Enrique Niño P. Leviste

Asia-Pacific Social Science Review

The study examined the results of the civic writing project “Letter to the Next President of the Philippines,” where grades 9-10 students were asked to write a letter to the next president about social problems that they wanted their future leader to resolve and why. The study analyzed the students’ letter topics according to their school type and location, gender, and the students’ sources of information for their civic writing. The letters (N=322) were written by students from urban and rural, and public and private schools across the country in March-May 2022 before the Philippine presidential election. The quantitative analysis …

Development And Validation Of The Malaysia Cybervictimization Scale For Adolescents In Malay And Chinese Version, Poh Chua Siah, Xiang Yi Tee, Chee-Seng Tan, Joanna Tjin Ai Tan, Komathi Lokithasan, Sew Kim Low, Chin Choo Yap

Asia-Pacific Social Science Review

The increasing rate of cybervictimization has been documented in various countries, including Malaysia. However, there is a dearth of measurement tools with sound psychometric properties suitable for the Malaysian context. To address this methodological gap, the Malaysia Cybervictimization Scale for Adolescents (MyCVS-A) was developed based on qualitative inputs from adolescents in Malaysia. It was subsequently translated into Malay (MyCVS-A-M) and Chinese (MyCVS-A-C). Two studies were conducted to examine the psychometric properties of these two translated versions. In Study 1, 281 secondary school students completed the MyCVS-A-M, the Malay version of the cybervictimization subscale of the European Cyberbullying Intervention Project Questionnaire …

Disruption Of Distal Appendage Protein Cep164 Causes Skeletal Malformation In Mice, Hiroyuki Yamaguchi, Megumi Kitami, Margaret Li, Sowmya Swaminathan, Radbod Darabi, Ken-Ichi Takemaru, Yoshihiro Komatsu

Faculty, Staff and Student Publications

The primary cilium is a cellular antenna to orchestrate cell growth and differentiation. Deficient or dysfunctional cilia are frequently linked to skeletal abnormalities. Previous research demonstrated that ciliary proteins regulating axoneme elongation are essential for skeletogenesis. However, the role of the ciliary proteins responsible for initiating cilium assembly in skeletal development remains unknown. Here, we investigate the function of centrosomal protein of 164 kDa (CEP164), a key ciliogenesis regulator that localizes at the distal appendages of the mother centriole, during skeletal development in mice. Interestingly, the mesodermal cell-specific Cep164 deletion resulted in severe bone defects and osteoblast-specific deletion of Cep164 …

Ethnic Differences In Ascending Aorta Dimensions And Dilatation Rates: A Systematic Review, Ayub Ansari, Kazi A. Syed, Mirza Baig, Yazan Tanbour, Abdullah Baghdadi, Aisha Ansari, Ayman Nada

Student Publications

Ethnic differences may substantially influence the morphological characteristics of the ascending aorta, with potential implications for clinical assessment and management of aortic dilatation. This systematic review evaluated the impact of ethnicity on ascending aorta diameter and dilatation rates, highlighting the need for more tailored, ethnicity-specific care in cardiovascular practice. We identified 11 studies that measured ascending aorta dimensions using transthoracic echocardiography (TTE), computed tomography (CT), or magnetic resonance imaging (MRI). Most investigations focused on Asian, Caucasian, African American, and Hispanic populations. Data extraction revealed notable variability in baseline aortic diameters across ethnic groups. Some studies found no significant differences between …

Front Matter

The Writing Center Journal

Front matter for The Writing Center Journal 42:3 (2024).

Road Safety Assessment For Accident And Non-Accident Cases Supporting Sustainable Development Goals 2030, Brian Nararya Nugraha, Sekar Warangi Nurcahyati, Hizkia Adhikaratma, Martha Leni Siregar

Journal of Environmental Science and Sustainable Development

Halving the number of global deaths and injuries from road traffic accidents is one target of the Sustainable Development Goals 2030, which is still a challenging problem in Indonesia. However, the majority of research on this topic uses accident-based methods, which limits the safety analysis. Two road safety assessment methods are used to close the gap, with the addition of non-accident-based methods such as Road Safety Audits (RSA). The Margonda Raya Road, which is categorised as a traffic accident blackspot, was selected for the case study. For this, a field survey of the road segment is carried out. To minimise …

Sustainable Practices And Green Marketing In Healthcare Sector: Visual Trends And Future Insight, Muhammad Alfarizi, Lissa Rosdiana Noer

Journal of Environmental Science and Sustainable Development

The healthcare sector faces critical challenges, including climate change, rising healthcare demands, and resource inefficiencies, making sustainability a priority. This study investigates the integration of sustainable practices and green marketing within the healthcare sector using a bibliometric analysis of 194 journal articles published from 2015 to 2024. Key research questions explore evolving trends, thematic areas, and gaps in the literature to address sustainability issues. The study employs a rigorous five-phase bibliometric methodology, utilizing Scopus database data and tools like Bibliometrix and VOSViewer to identify key themes and relationships. The research demonstrates an annual growth rate of 56.24%, reflecting the rising …

Addressing Unprofessional Behaviors In The Clinical Learning Environment: Lessons From A Multi-Year Virtual, Intergenerational, Interdisciplinary Workshop, Stacey Rose, Anita Kusnoor, Phuong Huynh, Jocelyn Greely, Yesenia Rojas-Khalil, Doris Kung, Anne Gill, Nadia Ismail, Nital Appelbaum

Faculty, Staff and Students Publications

INTRODUCTION: Optimizing the clinical learning environment (CLE) is a medical education priority nationwide.

MATERIALS AND METHODS: We developed a virtual, one-hour workshop engaging students, housestaff and faculty in small-group discussions of five case scenarios adapted from reported unprofessional behaviors in the CLE, plus didactics regarding mistreatment, microaggressions and bystander interventions.

RESULTS: Over two sessions (2021-2022), we engaged 340 students and 73 faculty/housestaff facilitators. Post-session surveys showed significant improvement in participants' ability to recognize and respond to challenges in the CLE.

DISCUSSION: Our innovative workshop, including scenarios derived from institutional reports of unprofessional behaviors, advanced participants' knowledge and commitment to improve …

Approved Car-T Therapies Have Reproducible Efficacy And Safety In Clinical Practice, Daniel Goyco Vera, Hiral Waghela, Mohamed Nuh, Jonathan Pan, Premal Lulla

Faculty, Staff and Students Publications

CAR-T cell therapy has established itself as a highly effective treatment for hematological malignancies. There are currently six commercial CAR-T products that have been FDA approved for diseases such as B-ALL, LBCL, MCL, FL, MM, and CLL/SLL. "Real-world" studies allow us to evaluate outcomes from the general population to determine their efficacy and safety compared to those who were included in the original trials. Based on several well conducted "Real-world" studies that represent diverse populations, we report that outcomes from the original trials that led to the approval of these therapies are comparable to those in practice.

Universality, Necessity, And Progress: Marx And The Problem Of History, Amy Allen

Emancipations: A Journal of Critical Social Analysis

To offer a compelling critique of the present, critical theory needs an account of capitalism that foregrounds its interrelation with the ongoing legacies of colonialism, imperialism, and slavery. To serve as a resource for such an account, Marx’s critique of capitalism and his theory of history need to be disentangled. This analysis revisits the problems of universality, necessity, and progress in Marx’s work in order to show how Marx’s consistently dialectical and critical account of capitalist modernity can be emancipated from the historicist framework that undergirds it.