Digital Commons Network^™

Editorial: Immunological Aspects Of Emerging And Re-Emerging Zoonoses, Wei Wang, Jingxin Li, Yuejin Liang, Wenping Gong

Faculty, Staff and Student Publications

No abstract provided.

Unicentric Castleman Disease: Illustration Of Its Morphologic Spectrum And Review Of The Differential Diagnosis, Siba El Hussein, Andrew G Evans, Hong Fang, Wei Wang, L Jeffrey Medeiros

Faculty, Staff and Student Publications

Context: Unicentric Castleman disease (UCD) is a dynamic entity with a wide spectrum of morphologic findings. UCD can be further subdivided into hyaline-vascular and mixed/plasmacytic variants. Hyaline-vascular UCD has both follicular and interfollicular (stromal) changes, and occasionally these lesions show a skewed representation of either the follicular or stromal compartments. Plasmacytosis is usually minimal in the hyaline-vascular variant. The mixed/plasmacytic variant of UCD is composed of sheets of plasma cells often associated with a variable number of follicles with regressive changes.

Objective: To illustrate the differential diagnosis of UCD, as it is quite broad and includes lymphomas, plasma cell neoplasms, …

Clinical Utility Of Plasma Microbial Cell-Free Dna Sequencing In Determining Microbiologic Etiology Of Infectious Syndromes In Solid Organ Transplant Recipients, John A Goss, Mayar Al Mohajer, Sarwat Khalil

Faculty, Staff and Students Publications

BACKGROUND: Metagenomic next-generation sequencing (mNGS) is increasingly being used for microbial detection in various infectious syndromes. However, data regarding the use of mNGS in solid organ transplant recipients (SOTR) are lacking.

OBJECTIVES: To describe and analyze real-world clinical impact of mNGS using plasma microbial cell-free DNA (mcfDNA) in SOTR.Design: Retrospectively reviewed all adult SOTR who underwent mNGS testing using plasma mcfDNA at Baylor St Luke's Medical Center from March 2017 to February 2023.

METHODS: Clinical impact (positive, neutral, and negative) was assessed using standardized objective criteria. Three Infectious Diseases physicians independently performed clinical adjudication to determine the correlation of mcfDNA …

The Impact Of The Filmarray Meningitis/Encephalitis Panel On Empiric Antibiotic Prescriptions In Patients With Suspected Community-Acquired Meningitis, Todd Lasco, Mayar Al Mohajer

Faculty, Staff and Students Publications

The BioFire® FilmArray® meningitis/encephalitis (FA/ME) panel provides rapid testing for common cerebrospinal fluid pathogens. We compared empiric antibiotic utilization between patients with suspected community-acquired meningitis with and without an FA/ME panel ordered. No significant differences in antibiotic use were found.

A Reinforcement Learning (Rl)-Motivated Simulation Framework For Evaluating Vancomycin Dosing Strategies, Bingyu Mao, Ziqian Xie, Laila Rasmy, Masayuki Nigo, Degui Zhi

Faculty, Staff and Student Publications

Achieving and maintaining the therapeutic range in vancomycin treatment is important for optimal outcomes. While guidelines and best practices based on empirical studies exist, the theoretical best dosing strategies under various conditions remain illusive. We developed an RL-based simulation framework using a deep learning two-compartment pharmacokinetic model (PK-RNN-2CM) and introduced the area under the time-concentration curve (AUC) reward score, which translates clinical guidelines into an RL reward. Ground truth time-concentration curves were generated from patient-specific data, and simulated curves were produced under different dosing strategies with optional noise perturbations to mimic real-world settings. Evaluation metrics included 24-hour AUC assessments and …

Effects Of Covid-19 On Sleep Services Use And Its Recovery, Samuel T Kuna, Javad Razjouyan

Faculty, Staff and Students Publications

PURPOSE: The COVID-19 pandemic affected the utilization of various healthcare services differentially. Sleep testing services utilization (STU), including Home Sleep Apnea Testing (HSAT) and Polysomnography (PSG), were uniquely affected. We assessed the effects of the pandemic on STU and its recovery using the Veterans Health Administration (VHA) data.

PATIENTS AND METHODS: A retrospective cohort study from the VHA between 01/2019 and 10/2023 of veterans with age ≥ 50. We extracted STU data using Current Procedural Terminology codes for five periods based on STU and vaccination status: pre-pandemic (Pre-Pan), pandemic sleep test moratorium (Pan-Mor), and pandemic pre-vaccination (Pan-Pre-Vax), vaccination (Pan-Vax), and …

Law Enforcement Use Of Genetic Genealogy Databases In Criminal Investigations: Nomenclature, Definition And Scope, Oliver M Tuazon, Ray A Wickenheiser, Ricky Ansell, Christi J Guerrini, Gerrit-Jan Zwenne, Bart Custers

Center for Medical Ethics and Health Policy Staff Publications

Although law enforcement use of commercial genetic genealogy databases has gained prominence since the arrest of the Golden State Killer in 2018, and it has been used in hundreds of cases in the United States and more recently in Europe and Australia, it does not have a standard nomenclature and scope. We analyzed the more common terms currently being used and propose a common nomenclature: investigative forensic genetic genealogy (iFGG). We define iFGG as the use by law enforcement of genetic genealogy combined with traditional genealogy to generate suspect investigational leads from forensic samples in criminal investigations. We describe iFGG …

The Determinants Of Nonprofit Hospital Ceo Compensation, Derek Jenkins, Marah N Short, Vivian Ho

Center for Medical Ethics and Health Policy Staff Publications

Hospital CEO salaries have grown quickly over the past two decades. We investigate correlates of rising nonprofit hospital CEO pay between 2012 and 2019 by merging compensation data from Candid's IRS 990 forms with hospital data from the National Academy for State Health Policy Hospital Cost Tool. Almost half of the measured increase in CEO compensation (44.5%) accrued to a "base case" CEO, who was leading a non-teaching hospital system or independent hospital with fewer than 100 beds that earned 0 profits and provided no charity care. Another 28.5% of the measured salary increase resulted from changes in the generosity …

Tfeb-Vacuolar Atpase Signaling Regulates Lysosomal Function And Microglial Activation In Tauopathy, Baiping Wang, Heidi Martini-Stoica, Chuangye Qi, Tzu-Chiao Lu, Shuo Wang, Wen Xiong, Yanyan Qi, Yin Xu, Marco Sardiello, Hongjie Li, Hui Zheng

Center on Aging Staff Publications

Transcription factor EB (TFEB) mediates gene expression through binding to the coordinated lysosome expression and regulation (CLEAR) sequence. TFEB targets include subunits of the vacuolar ATPase (v-ATPase), which are essential for lysosome acidification. Single-nucleus RNA sequencing of wild-type and PS19 (Tau) transgenic mice expressing the P301S mutant tau identified three unique microglia subclusters in Tau mice that were associated with heightened lysosome and immune pathway genes. To explore the lysosome-immune relationship, we specifically disrupted the TFEB-v-ATPase signaling by creating a knock-in mouse line in which the CLEAR sequence of one of the v-ATPase subunits, Atp6v1h, was mutated. CLEAR mutant exhibited …

Mapping Kinnikinnick And Assessing Habitat Factors For Brown Elfin Butterfly At The North Ma-Le’L Dunes, California, Harper Lacey, Elizabeth Mcguire, Sienna Tubridy, Mark Mckenna

Undergraduate Scholarship

Climate change, caused by anthropogenic influence, has resulted in rising temperatures across the globe. This has contributed to sea level rise which has negatively impacted coastal endangered species. Rising temperatures threaten habitat conditions through fragmentation and encroachment of invasive species. Habitat fragmentation and the spread of invasive species have already been worsened by European colonialistic ideas of exploiting the environment for its natural resources, which makes sea level rise an additional issue. California has been affected by sea level rise in various ways and dune ecosystems are experiencing many of those impacts. In Humboldt County, our project site borders the …

Did January 6 Defendants (Including Donald Trump) “Otherwise Obstruct An Official Proceeding”? Linguistic Analysis For The Fischer Case Before The Supreme Court, Clark Cunningham, Ute Römer-Barron

Faculty Publications By Year

When judges, skilled and sophisticated users of the English language, come to opposing conclusions about the “plain” or “ordinary” meaning of a phrase, how can such a conflict be resolved in an objective way? Traditionally courts have resorted to citing dictionary definitions, but in recent years an alternative approach has been gaining attention and respect: the use of corpus linguistics. The supreme courts of Michigan, Idaho, Utah, Vermont have used made use of corpus-based research in their decisions as has the U.S. Court of Appeals for the Third Circuit. Both the Sixth Circuit and the Ninth Circuit have requested that …

Pregnancy-Related Factors Responsible For Delivering Low Birth Weight Babies: An Institutional-Based Cross-Sectional Study, Jamnagar, Gujarat, Dipesh V Parmar

Faculty, Staff and Student Publications

BACKGROUND: The WHO defines LBW as "Birth weight less than 2500 grams" regardless of gestational age. Being born with a low birth weight also incurs enormous economic costs, including higher medical expenditures and social service expenses, and decreased productivity in adulthood.

OBJECTIVE: To study distribution of newborns' according to pregnancy related factors and its association with newborns' birth weight.

METHODS: An institutional based cross-sectional study. New-borns delivered at study institute were considered as study participants. Estimated final sample size was 500. Guardians (mothers) were face-to-face interviewed and also recorded data were collected from the case file and Mother and Child …

Dietary Practices Among Type 2 Diabetes Patients Visiting A Non-Communicable Disease (Ncd) Clinic In A District Of Western India: A Cross-Sectional Study

Faculty, Staff and Student Publications

BACKGROUND AND AIMS: Diabetes is becoming a major public health problem in the country. One of the most important lifestyle modifications necessary for diabetic patients is maintaining healthy dietary choices. These modifications in dietary practices are supposed to be followed lifelong, along with medication, for better glycemic control. Despite understanding the importance of dietary control and physical activity in the management of diabetes, adherence to these practices is poor. This study aimed to assess the dietary practices of type 2 diabetes mellitus (T2DM) patients and various factors that determine adherence to these healthy dietary practices. The secondary objective was to …

Healthcare Utilization And Clinical Characteristics Of Genetic Epilepsy In Electronic Health Records, Gokul Krishnaswamy, Elia M Pestana-Knight, Imad Najm, Dennis Lal

Faculty, Staff and Student Publications

Understanding the clinical characteristics and medical treatment of individuals affected by genetic epilepsies is instrumental in guiding selection for genetic testing, defining the phenotype range of these rare disorders, optimizing patient care pathways and pinpointing unaddressed medical need by quantifying healthcare resource utilization. To date, a matched longitudinal cohort study encompassing the entire spectrum of clinical characteristics and medical treatment from childhood through adolescence has not been performed. We identified individuals with genetic and non-genetic epilepsies and onset at ages 0–5 years by linkage across the Cleveland Clinic Health System. We used natural language processing to extract medical terms and …

Mohs Surgery For Squamoid Eccrine Ductal Carcinoma

Faculty, Staff and Student Publications

Squamous eccrine ductal carcinoma is a rare cutaneous malignancy. It has the potential to locally recur and may occasionally metastasize. It presents a diagnostic challenge given its rare nature and overlapping histopathological features with other cutaneous carcinomas.

Key Messages: An 82-year-old woman presented with a right cheek squamoid eccrine ductal carcinoma and was treated with Mohs surgery. Squamoid eccrine ductal carcinoma is a rare malignancy with potential for metastasis. It is a diagnostic challenge as it has overlapping histopathological features with squamous cell carcinoma and other eccrine malignancies.

Spinal Cord Evaluation In Multiple Sclerosis: Clinical And Radiological Associations, Present And Future, Roland G Henry, Cornelia Laule, John A Lincoln, Steven Messina, Jiwon Oh, Nico Papinutto, Seth Aaron Smith, Anthony Traboulsee

Faculty, Staff and Student Publications

Spinal cord disease is important in most people with multiple sclerosis, but assessment remains less emphasized in patient care, basic and clinical research and therapeutic trials. The North American Imaging in Multiple Sclerosis Spinal Cord Interest Group was formed to determine and present the contemporary landscape of multiple sclerosis spinal cord evaluation, further existing and advanced spinal cord imaging techniques, and foster collaborative work. Important themes arose: (i) multiple sclerosis spinal cord lesions (differential diagnosis, association with clinical course); (ii) spinal cord radiological-pathological associations; (iii) 'critical' spinal cord lesions; (iv) multiple sclerosis topographical model; (v) spinal cord atrophy; and (vi) …

Characterizing Treatment Non-Responders And Responders In Completed Alzheimer's Disease Clinical Trials, Xiaoqian Jiang

Faculty, Staff and Student Publications

Characterizing differential responses to Alzheimer's disease (AD) drugs will provide better insights into personalized treatment strategies. Our study aims to identify heterogeneous treatment effects and pre-treatment features that moderate the treatment effect of Galantamine, Bapineuzumab, and Semagacestat from completed trial data. The causal forest method can capture heterogeneity in treatment responses. We applied causal forest modeling to estimate the treatment effect and identify efficacy moderators in each trial. We found several patient's pretreatment conditions that determined treatment efficacy. For example, in Galantamine trials, whole brain volume (1092.54 vs. 1060.67 ml, P < .001) and right hippocampal volume (2.43e-3 vs. 2.79e-3, P < .001) are significantly different between responsive and non-responsive subgroups. Overall, our implementation of causal forests in AD clinical trials reveals the heterogeneous treatment effects and different moderators for AD drug responses, highlighting promising personalized treatment based on patient-specific characteristics in AD research and drug development.

Authoritarian Fantasies And Democratic Aspirations: The Philippines After Duterte, Athena Charanne R. Presto, Nicole Curato

Political Science Department Faculty Publications

Former Philippine President Rodrigo Duterte defied established political norms in the Philippines. Beyond his inflammatory rhetoric and authoritarian posturing, Duterte actively undermined institutions of liberal democracy including due process, gender rights, and freedom of the press. These developments may give observers the impression that democratic political norms in the Philippines have made a turn for the worse. After all, President Duterte, as his presidential term came to an end, continued to enjoy an excellent public satisfaction rating. We seek to challenge these impressions in this chapter. We argue that the President's popularity must not be conflated with public support for …

Internal And Social Sources Shape Judgments About The Mental And Physical Nature Of An Experience, Jacinth Jia Xin Tan, Alexander Karan, Dolores Albarracin

Research Collection School of Social Sciences

Although humans are intuitive dualists, little is known about whether they hold lay beliefs about the origins or sources of their intuitive perceptions of what is physical and what is mental. Drawing on theories of the sources of phenomenological experiences, we examined if people hold beliefs about the internal and social origins of judments that their experiences are physical or mental. In Study 1, participants provided physical or mental judgments about a range of personal experiences, and reported relying on both internal (i.e., examining own body and thoughts) and social (i.e., observing others) sources as information for their judgments. To …

The Future Of The International Financial System: The Emerging Cbdc Network And Its Impact On Regulation, Heng Wang, Simin Gao

Research Collection Yong Pung How School Of Law

Central bank digital currency (CBDC) is a digital form of fiat currency. CBDC has the potential to be a game challenger in the international financial system, bringing increased complexities arising from technology and regulatory considerations, as well as generating greater currency competition. As more states begin exploring CBDC, the interactions between actors may lead to the emergence of a new CBDC network. What shape would the emerging CBDC network take? What would its network effects be? What would be the impact of the CBDC network on the international financial system, or the global financial network? This article explores these questions …

Lion City Zoopolis: Urban Crittizenship In Biophilic Singapore, George Wong

Research Collection School of Social Sciences

A central theme of Singapore’s “City in Nature” vision is framed through biophilic urbanism, or efforts to harmonize biodiversity and urban development through built, social, and political design. The central discourses of Singapore’s biophilic urbanism have revolved around flora-centric paradigms, including habitat conservation, greening spaces, and access to natural capital. This paper detours from conventions of Singapore’s urban ecological futures and instead explores the governance of fauna co- existence in the city–state through the concept of “urban crittizenship.” Defined as a more-than-human denization framework that interrogates urban wildlife governance, urban crittizenship interrogates the politics of urban wildlife’s rights to the …

An Integrated Theory Of Happiness: The Yang Zhu Chapter Of The Liezi, Devin K. Joshi

Research Collection School of Social Sciences

This article examines the integrated approach to theorizing happiness in the Yang Zhu chapter of the book associated with the Daoist master Liezi. While ancient critics famously denounced Yang Zhu as an amoral, pleasure-seeking hedonist, I argue the Yang Zhu chapter offers an individually rational but socially non-conformist approach to well-being of considerable relevance to contemporary scholarship on happiness. Not only does the chapter offer an intriguing and counter-intuitive argument about what constitutes and causes well-being, but its philosophical implications address a large number of inescapably foundational conceptual questions that can serve as metrics for evaluating theories of happiness in …

Climate-Related Shareholder Activism As Corporate Democracy: A Call To Reform “Acting In Concert” Rules, Dan W. Puchniak, Umakanth Varottil

Research Collection Yong Pung How School Of Law

Climate change is an issue of global importance, which may turn out to be the issue of this century. Companies are at the core of both the problems and solutions for climate change. Given this reality, it is astounding that in virtually all jurisdictions in the world ‘acting in concert rules,’ which were designed decades ago to facilitate an efficient market for corporate control, effectively prevent shareholders who hold a majority of shares from democratically replacing boards of dirty companies. Our Article exposes this overlooked reality by undertaking the first in-depth comparative analysis of acting in concert rules with a …

Not Why, But How: Applying The Sharp Edge Of The Law In Administrative Law Judicial Review In Singapore, Tan K. B. Eugene

Research Collection Yong Pung How School Of Law

The management and control of power, and, in particular, the endeavour to strike the appropriate balance between affording governments the ability to act swiftly and decisively in the public interest while providing for adequate safeguards against governmental excess, is an intensely difficult undertaking. There is no one model that is correct for all times and all places.

Responding To Reading Difficulties: An Exploration From Different Professional Perspectives, Ezgi Unlu

School of Law, Humanities and Social Sciences Theses

The study was designed to explore educators’ perspectives on reading difficulties and their choice of teaching strategies for students with reading difficulties. The study aimed to understand how educators form their professional perspectives on reading difficulties, how this relates to their understanding of the concept of ‘dyslexia’ and how this informs their teaching methods. Furthermore, the study has explored the extent to which these chosen teaching strategies are inclusive and meet the needs of all students. A qualitative case study was used to generate data to address the research questions and achieve the aims of this study. Data were generated …

Exploring Parents’ And Teachers’ Experience Of A Novel Programme: Safe With Schools [Swis] – A Systemic Attachment-Based Approach For Caregivers Of Autistic Children, Tara Vassallo

School of Law, Humanities and Social Sciences Theses

This research explored the experience of thirty-two parents and teachers of autistic children, from nine schools in the southwest of England participating in a novel systemic attachment-based programme SAFE with Schools (SwiS). Designed as a competency-based framework with a non-blaming approach using established techniques and activities drawn from systemic family therapy, the SwiS programme was employed to engage parents and teachers experiencing autism-related difficulties. The aim was to explore their experience of SwiS and in turn how these caregivers made meaning of autism through the systemic attachment-focus of SwiS, what it revealed about the nature of the parent-teacher-child system, and …

Evidence-Based Teaching: Discourses Of Pedagogy And Positionality, Jacklyn Barry

School of Law, Humanities and Social Sciences Theses

This critical discourse analysis (CDA) addresses the gap in research about teachers’ identities in primary schools (Rushton et al., 2023: 15). It does so by drawing upon aspects of Bernstein’s theories of the pedagogic device to explore the impact of evidence-based training practices on teachers’ positionalities in primary schools in one MAT in the South West of England. Using the prompt of brain-based interventions, how the use of research evidence might affect the ongoing development of teachers’ pedagogies was explored. Through interviews with 15 stakeholders in four primary schools, and a document analysis of ten resources related to the themes …

How Does Living In A Rural Location Affect Experiences Of Acquired Vision Impairment?, Rebecca Woods

School of Law, Humanities and Social Sciences Theses

This research explores the lived experiences of adults with acquired sight loss who live in rural areas in Southwest England. There is a scarcity of published academic research with this group. Vision impaired people who live in rural locations are therefore unrecognised sources of vision impairment rehabilitation knowledge. The research is conducted in an interpretivist paradigm. The research is guided by phenomenological understanding, rooted in Merleau-Ponty’s concepts of perception, the centrality of tool-use, and human embodiment. Attention is centred on the process of adapting to sight loss in a domestic setting, placing this research in an experiential, community-based educational context. …

University Sustainability In Times Of Uncertainty: The Impact Of Brexit On Eu Staff And Students, Diane Stanley

School of Law, Humanities and Social Sciences Theses

The Brexit referendum in June 2016, which led to the UK’s decision to leave the European Union (EU), generated significant concern and anxiety within the United Kingdom's (UK) Higher Education (HE) sector. The potential impact on EU student and staff recruitment, EU research funding, and collaborations with Europe was uncertain, as many Brexit policies and procedures had not been considered by the government when the Leave outcome was announced. EU staff and students working and studying in UK Higher Education Institutions (HEIs) were left contemplating their future in the UK. This thesis examines the impact of Brexit through Charles Wright …

What Goes In And What Comes Out: A Scoping Review Of Regenerative Agricultural Practices, Rebecca Voisin, Pierre Horwitz, Stephanie Godrich, Ros Sambell, Katherine Cullerton, Amanda Devine

Research outputs 2022 to 2026

This scoping review examined peer-reviewed and gray literature to explore what a “no-to-low external input” statement means for regenerative agriculture. Five organic amendment inputs (compost extract, manure, mulch, biochar, food systems waste) and four land management processes (livestock management and integration, crop diversity, tillage reduction, comprehensive approach) were identified. Findings include “no-to-low external input” models arising from processes which function to displace external inputs (e.g., synthetic fertilizer). Organic amendment inputs and regenerative land management processes promote biology and improve nutrient cycling at soil, farm, and landscape scales. Regenerative agriculture overlaps with other farming practices including those associated with agroecology and …