Digital Commons Network^™

Clinical Evaluation Of A Fully Electronic Microfluidic White Blood Cell Analyzer, Jianye Sui, Zhongtian Lin, Shahriar Azizpour, Fei Chen, Sunanda Gaur, Kelly Keene, Farzad Soleimani, Tanaya Bhowmick, Zubaid Rafique, Mehdi Javanmard

Faculty, Staff and Students Publications

The White Blood Cell (WBC) count is one of the key parameters signaling the health of the immune system. Abnormal WBC counts often signal a systemic insult to the body such as an underlying infection or an adverse side effect to medication. Typically, the blood collected is sent to a central lab for testing, and results come back within hours, which is often inconvenient and may delay time-sensitive diagnosis or treatment. Here, we present the CytoTracker, a fully electronic, microfluidic based instant WBC analyzer with the potential to be used at point-of-care. The CytoTracker is a lightweight, portable, affordable platform …

Hepatocellular Carcinoma Incidence Threshold For Surveillance In Virologically Cured Hepatitis C Individuals, Jagpreet Chhatwal, Ali Hajjar, Peter P Mueller, Gizem Nemutlu, Neeti Kulkarni, Mary Linton B Peters, Fasiha Kanwal

Faculty, Staff and Students Publications

Background & aims: Guidelines recommend biannual surveillance for hepatocellular carcinoma (HCC) in hepatitis C individuals with cirrhosis if the HCC incidence rate is above 1.5 per 100 person-years (PY). However, the incidence threshold for surveillance in individuals who achieve a virologic cure is unknown. We estimated the HCC incidence rate above which routine HCC surveillance is cost-effective in this growing population of virologically cured hepatitis C individuals with cirrhosis or advanced fibrosis.

Methods: We developed a Markov-based microsimulation model of the natural history of HCC in individuals with hepatitis C who achieved virologic cure with oral direct-acting antivirals. We used …

Dolutegravir Induces Folr1 Expression During Brain Organoid Development, Carlo Donato Caiaffa, Gabriel Tukeman, Christian Zevallos Delgado, Yogeshwari S Ambekar, Taye T Mekonnen, Manmohan Singh, Victoria Rodriguez, Emily Ricco, Daniel Kraushaar, Salavat R Aglyamov, Giuliano Scarcelli, Kirill V Larin, Richard H Finnell, Robert M Cabrera

Faculty, Staff and Students Publications

During the first month of pregnancy, the brain and spinal cord are formed through a process called neurulation. However, this process can be altered by low serum levels of folic acid, environmental factors, or genetic predispositions. In 2018, a surveillance study in Botswana, a country with a high incidence of human immunodeficiency virus (HIV) and lacking mandatory food folate fortification programs, found that newborns whose mothers were taking dolutegravir (DTG) during the first trimester of pregnancy had an increased risk of neural tube defects (NTDs). As a result, the World Health Organization and the U.S. Food and Drug Administration have …

The 6 Degrees Of Curriculum Integration In Medical Education In The United States, Julie Youm, Jennifer Christner, Kevin Hittle, Paul Ko, Cinda Stone, Angela D Blood, Samara Ginzburg

Faculty, Staff and Students Publications

Despite explicit expectations and accreditation requirements for integrated curriculum, there needs to be more clarity around an accepted common definition, best practices for implementation, and criteria for successful curriculum integration. To address the lack of consensus surrounding integration, we reviewed the literature and herein propose a definition for curriculum integration for the medical education audience. We further believe that medical education is ready to move beyond “horizontal” (1-dimensional) and “vertical” (2-dimensional) integration and propose a model of “6 degrees of curriculum integration” to expand the 2-dimensional concept for future designs of medical education programs and best prepare learners to meet …

Understanding The Education Profiles Of Seven East And Southern African Countries, Girl Center

Adolescents and Young People

Despite significant progress in improving primary enrollment and attainment for girls in low- and middle-income countries (LMICs) in recent years, gender disparities in education persist and hinder opportunities for girls. Educational attainment for girls has plateaued in numerous countries, with only a few making significant strides in narrowing the gender gap. Moreover, attainment alone does not always translate to improved learning. Gender-related barriers such as school environments that are not conducive to learning and the experience of violence, early and forced marriage, and early childbearing, as well as a lack of support for girls’ education impede attainment and learning. The …

Understanding The Education Profiles Of Eight Latin American Countries, Girl Center

Adolescents and Young People

Despite significant progress in improving primary enrollment and attainment for girls in low- and middle-income countries (LMICs) in recent years, gender disparities in education persist and hinder opportunities for girls. Educational attainment for girls has plateaued in numerous countries, with only a few making significant strides in narrowing the gender gap. Moreover, attainment alone does not always translate to improved learning. Gender-related barriers such as school environments that are not conducive to learning and the experience of violence, early and forced marriage, and early childbearing, as well as a lack of support for girls’ education impede attainment and learning. The …

Support For Girls’ Education And Keeping Them In School, Population Council, Swedd

Adolescents and Young People

SWEDD Series: Best Practice Guide no. 2

This Guide is one of a series that retrospectively documents the process of implementing the interventions of the SWEDD project, and documents good practices, challenges and lessons learned. The “Sahel Women's Empowerment and Demographic Dividend” (SWEDD) project was launched in November 2015 with financial support from the World Bank, and technical support from the United Nations Population Fund (UNFPA) and the West African Health Organisation (WAHO). The research informing this Guide was led by the Population Council.

Le Développement Curriculaire Pour Les Espaces Sûrs, Population Council, Swedd

Adolescents and Young People

Série SWEDD: Guide de Bonnes Pratiques no. 3

Ce Guide fait partie d’une série qui documente d’une manière rétrospective le processus de mise en œuvre des interventions du projet SWEDD, et décrit les bonnes pratiques, les défis et les leçons apprises. Le projet “Autonomisation des Femmes et Dividende Démographique au Sahel” (SWEDD) a été lancé en novembre 2015 avec le soutien financier de la Banque mondiale, et l’appui technique du Fonds des Nations Unies pour la population (UNFPA) et de l’Organisation Ouest -Africaine pour la Santé (OOAS). Les recherches menant à ce Guide ont été dirigées par le Population …

Curriculum Development For Safe Spaces, Population Council, Swedd

Adolescents and Young People

SWEDD Series: Best Practice Guide no. 3

This Guide is one of a series that retrospectively documents the process of implementing the interventions of the SWEDD project, and documents good practices, challenges and lessons learned. The “Sahel Women's Empowerment and Demographic Dividend” (SWEDD) project was launched in November 2015 with financial support from the World Bank, and technical support from the United Nations Population Fund (UNFPA) and the West African Health Organisation (WAHO). The research informing this Guide was led by the Population Council.

Safe Spaces, Population Council, Swedd

Adolescents and Young People

SWEDD Series: Best Practice Guide no. 4

This Guide is one of a series that retrospectively documents the process of implementing the interventions of the SWEDD project, and documents good practices, challenges and lessons learned. The “Sahel Women's Empowerment and Demographic Dividend” (SWEDD) project was launched in November 2015 with financial support from the World Bank, and technical support from the United Nations Population Fund (UNFPA) and the West African Health Organisation (WAHO). The research informing this Guide was led by the Population Council.

Le Soutien À La Scolarisation Des Filles Et Leur Maintien À L’École, Population Council, Swedd

Adolescents and Young People

Série SWEDD: Guide de Bonnes Pratiques no. 2

Ce Guide fait partie d’une série qui documente d’une manière rétrospective le processus de mise en œuvre des interventions du projet SWEDD, et décrit les bonnes pratiques, les défis et les leçons apprises. Le projet “Autonomisation des Femmes et Dividende Démographique au Sahel” (SWEDD) a été lancé en novembre 2015 avec le soutien financier de la Banque mondiale, et l’appui technique du Fonds des Nations Unies pour la population (UNFPA) et de l’Organisation Ouest -Africaine pour la Santé (OOAS). Les recherches menant à ce Guide ont été dirigées par le Population …

The Role Of Group Leaders In Safe Spaces And Clubs For Husbands/Future Husbands, Population Council, Equimundo, Swedd

Adolescents and Young People

SWEDD Series: Best Practice Guide no. 6

This Guide is one of a series that retrospectively documents the process of implementing the interventions of the SWEDD project, and documents good practices, challenges and lessons learned. The “Sahel Women's Empowerment and Demographic Dividend” (SWEDD) project was launched in November 2015 with financial support from the World Bank, and technical support from the United Nations Population Fund (UNFPA) and the West African Health Organisation (WAHO). The research informing this Guide was led by the Population Council and Equimundo.

Le Rôle Des Leaders De Groupes Dans Les Espaces Sûrs Et Les Clubs Des Maris/Futurs Maris, Population Council, Equimundo, Swedd

Adolescents and Young People

Série SWEDD: Guide de Bonnes Pratiques no. 6

Ce Guide fait partie d’une série qui documente d’une manière rétrospective le processus de mise en œuvre des interventions du projet SWEDD, et décrit les bonnes pratiques, les défis et les leçons apprises. Le projet “Autonomisation des Femmes et Dividende Démographique au Sahel” (SWEDD) a été lancé en novembre 2015 avec le soutien financier de la Banque mondiale, et l’appui technique du Fonds des Nations Unies pour la population (UNFPA) et de l’Organisation Ouest -Africaine pour la Santé (OOAS). Les recherches menant à ce Guide ont été dirigées par le Population …

Les Espaces Sûrs, Population Council, Swedd

Adolescents and Young People

Série SWEDD: Guide de Bonnes Pratiques no. 4

Ce Guide fait partie d’une série qui documente d’une manière rétrospective le processus de mise en œuvre des interventions du projet SWEDD, et décrit les bonnes pratiques, les défis et les leçons apprises. Le projet “Autonomisation des Femmes et Dividende Démographique au Sahel” (SWEDD) a été lancé en novembre 2015 avec le soutien financier de la Banque mondiale, et l’appui technique du Fonds des Nations Unies pour la population (UNFPA) et de l’Organisation Ouest -Africaine pour la Santé (OOAS). Les recherches menant à ce Guide ont été dirigées par le Population …

Diminished Tmem100 Expression In A Newborn With Acinar Dysplasia And A Novel Tbx4 Variant: A Case Report, Przemyslaw Szafranski, Silvia Patrizi, Tomasz Gambin, Bushra Afzal, Emily Schlotterbeck, Justyna A Karolak, Gail Deutsch, Drucilla Roberts, Paweł Stankiewicz

Faculty, Staff and Students Publications

Acinar dysplasia (AcDys) of the lung is a rare lethal developmental disorder in neonates characterized by severe respiratory failure and pulmonary arterial hypertension refractory to treatment. Recently, abnormalities of TBX4-FGF10-FGFR2-TMEM100 signaling regulating lung development have been reported in patients with AcDys due to heterozygous single-nucleotide variants (SNVs) or copy-number variant (CNV) deletions involving TBX4, FGF10, or FGFR2. Here, we describe a female neonate who died at 4 hours of life due to severe respiratory distress related to AcDys diagnosed by postmortem histopathologic evaluation. Genomic analyses revealed a novel deleterious heterozygous missense variant c.728A>C (p.Asn243Thr) in TBX4 that arose …

From High-Throughput Transcriptome Characterization Of Individual Synaptosomes To Constructing The Whole-Brain Connectome, Muchun Niu, Chenghang Zong

Faculty, Staff and Students Publications

No abstract provided.

Advances In Nanoprobes For Molecular Mri Of Alzheimer’S Disease, Parag Parekh, Andrew A Badachhape, Eric A Tanifum, Ananth V Annapragada, Ketan B Ghaghada

Faculty, Staff and Students Publications

Alzheimer's disease is the most common cause of dementia and a leading cause of mortality in the elderly population. Diagnosis of Alzheimer's disease has traditionally relied on evaluation of clinical symptoms for cognitive impairment with a definitive diagnosis requiring post-mortem demonstration of neuropathology. However, advances in disease pathogenesis have revealed that patients exhibit Alzheimer's disease pathology several decades before the manifestation of clinical symptoms. Magnetic resonance imaging (MRI) plays an important role in the management of patients with Alzheimer's disease. The clinical availability of molecular MRI (mMRI) contrast agents can revolutionize the diagnosis of Alzheimer's disease. In this article, we …

Generation And Characterization Of In Vitro Transcribed Mrna, Cristina Poveda, Yi-Lin Chen, Ulrich Strych

Faculty, Staff and Students Publications

Here we describe the in vitro preparation of mRNA from DNA templates, including setting up the transcription reaction, mRNA capping, and mRNA labeling. We then describe methods used for mRNA characterization, including UV and fluorescence spectrophotometry, as well as gel electrophoresis. Moreover, characterization of the in vitro transcribed RNA using the Bioanalyzer instrument is described, allowing a higher resolution analysis of the target molecules. For the in vitro testing of the mRNA molecules, we include protocols for the transfection of various primary cell cultures and the confirmation of translation by intracellular staining and western blotting.

P2y12 Inhibitor Monotherapy Versus Long-Term Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Meta-Analysis Of Randomized Controlled Trials, Mushood Ahmed, Areeba Ahsan, Priyansha Singh, Adeel Ahmad, Hritvik Jain, Asad Rahman, Sohail Q Khan, Raheel Ahmed, Mahboob Alam, Farhan Shahid

Faculty, Staff and Students Publications

No abstract provided.

“Muchakang Pangkalawakan”: Queering Engagements With Bakla Of The Philippine Tropics, Artemio P. Millo

Sociology & Anthropology Department Faculty Publications

The performance of participants in the Miss Gay Muchakang Pangkalawan [Miss Ugly Gay Universe] in Quiapo, Manila, reflects characteristics of the flamboyant and effeminate bakla. However, these stereotypical depictions may not always be consistent with how participants view themselves. This study argues that an introspective understanding of how participants make sense of their identity work engendered by ever-turning tropes reveals slippages that can liberate them from existing oppressive stereotypes. By utilizing personal narrative and ethnographic reflexivity, this study deconstructs the participants’ performances, revealing identity-making that may reinforce or resist dominant discourses on the bakla under which these narratives are …

Best Practice Recommendations For Coaching Gymnasts To Avoid Burnout And Reframe Performance Anxiety, Clare A. Mccall

Theses: Doctorates and Masters

Gymnastics is deemed a psychologically demanding sport, with associated risk factors of burnout and performance anxiety. To date, relatively little research has explored the specific goal and perfectionistic processes of gymnasts, despite these risks. This body of work identified the specific goal-related constructs and perfectionistic orientation of young athletes and examined how these associated with burnout and performance anxiety. It comprised of two studies with a mixed methods design. The first study aimed to systematically review literature investigating how goal-related constructs and perfectionism associate with burnout and performance anxiety in young athletes. This review focused on summer and winter Olympic …

Attitudes And Perceptions Towards Privacy And Surveillance In Australia, Aleatha J. Shanley

Theses: Doctorates and Masters

Understanding attitudes towards privacy and surveillance technologies used to enhance security objectives is a complex, but crucial aspect for policy makers to consider. Historically, terrorism-related incidents justified the uptake of surveillance practices. More recently however, biosecurity concerns have motivated nation-states to adopt more intrusive surveillance measures. There is a growing body of literature that supports the public’s desire to maintain privacy despite fears of biological or physical threats.

This research set out to explore attitudes towards privacy and surveillance in an Australian context. Throughout the course of this endeavour, the COVID-19 pandemic emerged bringing with it a variety of track …

Searching For Equity In Positivity: A Two-Year Case Study Of The Effectiveness Of The Implementation Of Positive Education In A West Australian Public Secondary School Following A Year 7 Cohort To Year 8, Veronica J. Sutton

Theses: Doctorates and Masters

This research evaluated the effectiveness of explicitly teaching Positive Education to early adolescent learners transitioning into a metropolitan, secondary public school in Western Australia and to understand the source of their stress and where they felt supported. Based on teacher feedback, a model for embedding the development of social and emotional competencies (Equity in Positivity) in the Western Australian secondary metropolitan public-school context, in a sustainable and cost-effective way, was developed over a six year period and linked to the Australian Wellbeing Hub (2020).

The researcher adopted a mixed method, instrumental bounded case study methodology, longitudinally applied through the lens …

The Commonwealth Of Amnesia: A Collection Of Erasure And Cut-Up Poems Exploring The Forgotten Histories Of Croatian And Yugoslav Peoples In Australia And An Exegesis Obliteration Creates More: Examining The Wreck Of History Through Whiteout, Blackout And Cut-Up Erasure Poetry, Natalie Damjanovich-Napoleon

Theses: Doctorates and Masters

This thesis consists of two parts, a collection of poems, “The Commonwealth of Amnesia”, and an accompanying exegesis. The collection explores the forgotten histories of Croatian and Yugoslav immigrants in Australia from 1901 to 1957 through the medium of erasure and cut-up poetry, re-arranging words found in nonfiction documents to posit that forgetting can be metaphorically and visually represented through erasure while also re-narrativising a text. Erasure poetry takes a textual document and using whiteout or blackout erases portions of a text, transforming that text into a poem; cut-up poetry rearranges the words of a document in a textual version …

Preparing For End Of Life In A New Country: A Grounded Theory Study On African Migrants Living In Australia, Gertrude Gondwe Phiri

Theses: Doctorates and Masters

African migration to Australia has grown in the past 20 to 25 years with many migrants staying permanently. This has led to migrants dying away from their birthplaces where family is responsible for end-of-life care planning for the individual. Although migrating to Australia is considered a great achievement, many migrants also experienced challenges. Previous studies have explored the barriers faced by migrants in relation to end-of-life care but have not addressed the cause of those challenges. This constructivist grounded theory study examines how migrants from three African countries, Malawi, Zambia, and Zimbabwe (MZZ) prepare for end-of-life in Australia. The study …

Data Justice In Education: Toward A Research Agenda, Luci Pangrazio, Glenn Auld, Julianne Lynch, Carly Sawatzki, Gavin Duffy, Shelley Hannigan, Jo O'Mara

Articles

Educational institutions increasingly rely on digital platforms to deliver content and learning, monitor attendance, communicate with stakeholders, and evaluate institutional performance. Despite the efficiency and accessibility gains they offer, digital platforms are powered by personal data which, through a process of datafication, can be used to track, monitor, and profile staff and students. The insights drawn from this data can be used to shape educational and professional futures. This article examines how datafication has become a social justice issue in education, discussing the implications for well-being, decision-making, governance, and power in education. Using Hintz and colleagues framework for data justice, …

Enhancing Writing Quality And Self-Efficacy Beliefs Through Process-Oriented Task-Based Instruction And Multiple Feedback Forms, Samira Moussaoui

Journal of Educational and Psychological Studies

Abstract:This article presents the research findings of a quasi-experimental study seeking to enhance the writing quality and self-efficacy beliefs of Algerian undergraduate learners. The study employed task-based writing instruction within the process approach framework, and various forms of formative feedback (self-, peer-, and teacher feedback). The sample comprised 24 English as a foreign language (EFL) undergraduate learners with an intermediate level in academic writing. Data were collected through pre- and post-intervention writing tests to assess the participants’ writing quality, as well as pre- and post-intervention surveys, along with post-hoc interviews, to measure their writing self-efficacy levels. The analysis of the …

Use Of Social Media In Academic Library Services: A Case Study Of Dpsru Library, Yogita Ahuja Mrs.

Library Philosophy and Practice (e-journal)

Social media has ingrained itself into every aspect of our lives, including libraries. Social media is being used by libraries more and more to engage with users, advertise services, and foster a feeling of community. This term paper investigates how social media can be used to enhance library services, highlighting the transformative effects of social platforms on user engagement, the promotion of library resources, and the development of community. This paper will also present the examples of implementation of social media tool by DPSRU Library. Facebook, Instagram, YouTube, Research Gate have taken for representing this case study.

Protecting Feminist Culture Through Feminine Register In Speculative Fiction: Linking Curriculum And Reading For Pleasure In Nsw High Schools., Abdul Baseer

Library Philosophy and Practice (e-journal)

This paper presents a case for speculative fiction’s potential to uphold the feminist cause in our current global scenario of male violence. Young Adult (YA) and children’s speculative fiction around feminist themes should be included in high school libraries for pleasure for reading and forms of support to the current curriculum and to address contemporary social issues including patriarchy and less space for feminist agency. This writing suggests five titles in current speculative fiction built around the feminine register for inclusion in a New South Wales high school’s library collection targeting stages 5 and 6 students and linked to the …

Characterization And Individual-Level Prediction Of Cognitive State In The First Year After 'Mild' Stroke, Juan Pablo Saa, Tamara Tse, Gerald Choon-Huat Koh, Philip Yap, Carolyn M. Baum, David E. Uribe-Rivera, Saras M. Windecker, Henry Ma, Stephen M. Davis, Geoffrey A. Donnan, Leeanne M. Carey

2020-Current year OA Pubs

BACKGROUND: Mild stroke affects more than half the stroke population, yet there is limited evidence characterizing cognition over time in this population, especially with predictive approaches applicable at the individual-level. We aimed to identify patterns of recovery and the best combination of demographic, clinical, and lifestyle factors predicting individual-level cognitive state at 3- and 12-months after mild stroke.

METHODS: In this prospective cohort study, the Montreal Cognitive Assessment (MoCA) was administered at 3-7 days, 3- and 12-months post-stroke. Raw changes in MoCA and impairment rates (defined as MoCA<24 points) were compared between assessment time-points. Trajectory clusters were identified using variations of ≥1 point in MoCA scores. To further compare clusters, additional assessments administered at 3- and 12-months were included. Gamma and Quantile mixed-effects regression were used to predict individual MoCA scores over time, using baseline clinical and demographic variables. Model predictions were fitted for each stroke survivor and evaluated using model cross-validation to identify the overall best predictors of cognitive recovery.

RESULTS: Participants' (n = 119) MoCA scores improved from baseline to 3-months …