Digital Commons Network^™

A Scoping Review Of Population Diversity In The Common Genomic Aberrations Of Clear Cell Renal Cell Carcinoma, Sean S. Kumar, Ninad Khandekar, Komal Dani, Saina R. Bhatt, Vinay Duddalwar, Anishka D'Souza

Department of Medicine Faculty Publications

Introduction: Previous literature has shown that clear cell renal cell carcinoma (ccRCC) is becoming a more prevalent diagnosis and that the incidence and mortality differ both regionally and racially. While the molecular profiles for ccRCC are studied regionally through biopsy and sequencing techniques, the genomic landscape and ccRCC diversity data are not well-studied. We conducted a review of the known genomic data on 6 of the most clinically relevant DNA biomarkers in ccRCC: Von Hippel-Landau (vHL), Polybromo-1 (PBRM1), Breast Cancer Gene 1-Associated Protein 1 (BAP1), Histone-Lysine N-Methyltransferase Domain-Containing 2 (SETD2), Mammalian Target of Rapamycin (mTOR), and Lysine-Specific Demethylase 5C (KDM5C). …

Botulinum Toxin Treatment May Improve Myoelectric Pattern Recognition In Robot-Assisted Stroke Rehabilitation, Zhiyuan Lu, Yingchun Zhang, Sheng Li, Ping Zhou

Faculty, Staff and Student Publications

No abstract provided.

Effect Of Pioglitazone On Inflammatory Response And Clinical Outcome In T2dm Patients With Covid-19: A Randomized Multicenter Double-Blind Clinical Trial, Khaled Baagar, Thamer Alessa, Mohamed Abu-Farha, Jehad Abubaker, Heba Alhumaidi, Jose Antonio Franco Ceruto, Mohammad Khair Hamad, Ali Omrani, Salma Abdelrahman, Muhammad Zaka-Ul Haq, Abdul Wajid Safi, Bassem Alhariri, Manish Barman, Alaaeldin Abdelmajid, Humberto Vidal Denis Cancio, Eman Elmekaty, Irina Al-Khairi, Preethi Cherian, Lina Jayyousi, Mohammed Ahmed, Mohammed Qaddoumi, Sulaiman Hajji, Ahmad Esmaeel, Ali Al-Andaleeb, Arshad Channanath, Sriraman Devarajan, Hamad Ali, Thangavel Alphonse Thanaraj, Salman Al-Sabah, Fahd Al-Mulla, Muhammad Abdul-Ghani, Amin Jayyousi

Faculty, Staff and Student Publications

Background: Coronavirus disease 2019 (COVID-19) caused by the coronavirus SARS-CoV-2, has emerged as a rapidly spreading contagious disease across the globe. Recent studies showed that people with diabetes mellitus, severe obesity, and cardiovascular disease are at higher risk of mortality from COVID-19. It has been suggested that the increased risk is due to the chronic inflammatory state associated with type 2 diabetes. This study aimed to evaluate the efficacy of pioglitazone, a strong insulin sensitizer with anti-inflammatory properties, in improving the clinical outcomes of patients with type 2 diabetes admitted with moderate-severe COVID-19.

Method: We enrolled 350 patients with type …

Brazilian Psychiatric Association Treatment Guidelines For Generalized Anxiety Disorder: Perspectives On Pharmacological And Psychotherapeutic Approaches, Leonardo Baldaçara, Ana Beatriz Paschoal, Aldo Felipe Pinto, Fabiano Franca Loureiro, Luiz Antonio Vesco Gaiotto Antonio, Diogo De Lacerda Veiga, Thales Marcon Almeida, Diogo Cesar Dos Santos, Leandro Fernandes Malloy-Diniz, Marcelo Feijó De Mello, Andrea Feijó De Mello, Marsal Sanches, Lucas Marques Gandarela, Márcio Antonini Bernik, Antonio E Nardi, Antônio Geraldo Da Silva, Ricardo R Uchida

Faculty, Staff and Student Publications

Generalized anxiety disorder is a highly prevalent mental disorder. Previous data indicate that more than 18 million Brazilians suffer from this condition. Traditionally, generalized anxiety disorder has been considered a mild mental health disorder, despite its links to lower life expectancy, cardiovascular disease, and suicide. The aim of this article is to combine elements of systematic and critical reviews to produce a synthesis of the best evidence about generalized anxiety disorder treatment. Systematic reviews, meta-analyses, and randomized controlled trials were included. The descriptor used in the search was "generalized anxiety disorder," which resulted in 4,860 articles and seven other studies, …

Brain-Wide Functional Connectome Analysis Of 40,000 Individuals Reveals Brain Networks That Show Aging Effects In Older Adults, Yezhi Pan, Chuan Bi, Peter Kochunov, Michelle Shardell, J Carson Smith, Rozalina G Mccoy, Zhenyao Ye, Jiaao Yu, Tong Lu, Yifan Yang, Hwiyoung Lee, Song Liu, Si Gao, Yizhou Ma, Yiran Li, Chixiang Chen, Tianzhou Ma, Ze Wang, Thomas Nichols, L Elliot Hong, Shuo Chen

Faculty, Staff and Student Publications

The functional connectome changes with aging. We systematically evaluated aging-related alterations in the functional connectome using a whole-brain connectome network analysis in 39,675 participants in UK Biobank project. We used adaptive dense network discovery tools to identify networks directly associated with aging from resting-state functional magnetic resonance imaging (fMRI) data. We replicated our findings in 499 participants from the Lifespan Human Connectome Project in Aging study. The results consistently revealed two motor-related subnetworks (both with permutation test p-values < 0.001) that showed a decline in resting-state functional connectivity (rsFC) with increasing age. The first network primarily comprises sensorimotor and dorsal/ventral attention regions from precentral gyrus, postcentral gyrus, superior temporal gyrus, and insular gyrus, while the second network is exclusively composed of basal ganglia regions, namely the caudate, putamen, and globus pallidus. Path analysis indicates that white matter fractional anisotropy mediates 19.6% (p < 0.001, 95% CI [7.6% 36.0%]) and 11.5% (p < 0.001, 95% CI [6.3% 17.0%]) of the age-related decrease in both networks, respectively. The total volume of white matter hyperintensity mediates 32.1% (p < 0.001, 95% CI [16.8% 53.0%]) of the aging-related effect on rsFC in the first subnetwork.

Risk Stratification And Prediction Of Severity Of Covid-19 Infection In Patients With Preexisting Cardiovascular Disease, Stanislava Matejin, Igor D Gregoric, Rajko Radovancevic, Slobodan Paessler, Vladimir Perovic

Faculty, Staff and Student Publications

Introduction: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is a highly contagious viral disease. Cardiovascular diseases and heart failure elevate the risk of mechanical ventilation and fatal outcomes among COVID-19 patients, while COVID-19 itself increases the likelihood of adverse cardiovascular outcomes.

Methods: We collected blood samples and clinical data from hospitalized cardiovascular patients with and without proven COVID-19 infection in the time period before the vaccine became available. Statistical correlation analysis and machine learning were used to evaluate and identify individual parameters that could predict the risk of needing mechanical ventilation and patient survival.

Results: Our results confirmed that COVID-19 …

Synergistic Effects Of Β-Nafeo2 Ferrite Nanoparticles For Photocatalytic Degradation, Antibacterial, And Antioxidant Applications†, Forsad Al Hossain, M Tanjid Hasan Tonmoy, Sri Nuvvula, Brittany P Chapman, Rajesh K Gupta, Andrew A Lover, Rhoel R Dinglasan, Stephanie Carreiro, Tauhidur Rahman

Faculty, Staff and Student Publications

Syndromic surveillance is an effective tool for enabling the timely detection of infectious disease outbreaks and facilitating the implementation of effective mitigation strategies by public health authorities. While various information sources are currently utilized to collect syndromic signal data for analysis, the aggregated measurement of cough, an important symptom for many illnesses, is not widely employed as a syndromic signal. With recent advancements in ubiquitous sensing technologies, it becomes feasible to continuously measure population-level cough incidence in a contactless, unobtrusive, and automated manner. In this work, we demonstrate the utility of monitoring aggregated cough count as a syndromic indicator to …

The Uprmt Preserves Mitochondrial Import To Extend Lifespan, Jolaade Kalinowski, Elizabeth A Hintz, Chigozirim Izeogu

Faculty, Staff and Student Publications

The SARS-CoV-2 (COVID-19) pandemic introduced many challenges and nuances that have transformed medical practice and research. The uncertainty caused by COVID-19 led to inevitable challenges to patient-provider relationships. The ever-changing landscape of COVID-19 research and policy proved to be challenging for the medical community and patients. These challenges also exacerbated long-standing issues regarding patient-provider communication and trust. On the other hand, these challenges gave voice to a burgeoning patient advocacy community. Through social media, advocacy and patient organizing, patients harnessed their power and organized over challenges relating to COVID-19 fears and concerns, ramifications of "Long COVID," and much more. During …

Therapeutic Efficacy Of A Potent Anti-Venezuelan Equine Encephalitis Virus Antibody Is Contingent On Fc Effector Functionslc6a1 Variant Pathogenicity, Molecular Function And Phenotype: A Genetic And Clinical Analysis, Jennifer L Schwedler, Maxwell A Stefan, Christine E Thatcher, Peter R Mcilroy, Anupama Sinha, Ashlee M Phillips, Christopher A Sumner, Colleen M Courtney, Christina Y Kim, Dina R Weilhammer, Brooke Harmon

Faculty, Staff and Student Publications

The development of specific, safe, and potent monoclonal antibodies (Abs) has led to novel therapeutic options for infectious disease. In addition to preventing viral infection through neutralization, Abs can clear infected cells and induce immunomodulatory functions through engagement of their crystallizable fragment (Fc) with complement proteins and Fc receptors on immune cells. Little is known about the role of Fc effector functions of neutralizing Abs in the context of encephalitic alphavirus infection. To determine the role of Fc effector function in therapeutic efficacy against Venezuelan equine encephalitis virus (VEEV), we compared the potently neutralizing anti-VEEV human IgG F5 (hF5) Ab …

Healthcare Utilization And Clinical Characteristics Of Genetic Epilepsy In Electronic Health Records, Christian M Boßelmann, Alina Ivaniuk, Mark St John, Sara C Taylor, Gokul Krishnaswamy, Alex Milinovich, Costin Leu, Ajay Gupta, Elia M Pestana-Knight, Imad Najm, Dennis Lal

Faculty, Staff and Student Publications

Understanding the clinical characteristics and medical treatment of individuals affected by genetic epilepsies is instrumental in guiding selection for genetic testing, defining the phenotype range of these rare disorders, optimizing patient care pathways and pinpointing unaddressed medical need by quantifying healthcare resource utilization. To date, a matched longitudinal cohort study encompassing the entire spectrum of clinical characteristics and medical treatment from childhood through adolescence has not been performed. We identified individuals with genetic and non-genetic epilepsies and onset at ages 0–5 years by linkage across the Cleveland Clinic Health System. We used natural language processing to extract medical terms and …

Enhancing Associative Learning In Rats With A Computationally Designed Training Protocol, Xu O Zhang, Yili Zhang, Claire E Cho, Douglas S Engelke, Paul Smolen, John H Byrne, Fabricio H Do-Monte

Faculty, Staff and Student Publications

Background

Learning requires the activation of protein kinases with distinct temporal dynamics. In Aplysia, nonassociative learning can be enhanced by a computationally designed learning protocol with intertrial intervals (ITIs) that maximize the interaction between fast-activated PKA (protein kinase A) and slow-activated ERK (extracellular signal-regulated kinase). Whether a similar strategy can enhance associative learning in mammals is unknown.

Methods

We simulated 1000 training protocols with varying ITIs to predict an optimal protocol based on empirical data for PKA and ERK dynamics in rat hippocampus. Adult male rats received the optimal protocol or control protocols in auditory fear conditioning and fear …

Synaptic Vesicle Dynamics In Mouse Rod Bipolar Cells, Sara S Patterson, Rebecca J Girresch, Marcus A Mazzaferri, Andrea S Bordt, Wendy L Piñon-Teal, Brett D Jesse, Dinukie-Chantal W Perera, Melanie A Schlepphorst, James A Kuchenbecker, Alice Z Chuang, Jay Neitz, David W Marshak, Judith Mosinger Ogilvie

Faculty, Staff and Student Publications

Considerable progress has been made in studying the receptive fields of the most common primate retinal ganglion cell (RGC) types, such as parasol RGCs. Much less is known about the rarer primate RGC types and the circuitry that gives rise to noncanonical receptive field structures. The goal of this study was to analyze synaptic inputs to smooth monostratified RGCs to determine the origins of their complex spatial receptive fields, which contain isolated regions of high sensitivity called "hotspots." Interestingly, smooth monostratified RGCs co-stratify with the well-studied parasol RGCs and are thus constrained to receiving input from bipolar and amacrine cells …

Anesthetized Animal Experiments For Neuroscience Research, Shin Nagayama, Sanae Hasegawa-Ishii, Shu Kikuta

Faculty, Staff and Student Publications

Brain research has progressed with anesthetized animal experiments for a long time. Recent progress in research techniques allows us to measure neuronal activity in awake animals combined with behavioral tasks. The trends became more prominent in the last decade. This new research style triggers the paradigm shift in the research of brain science, and new insights into brain function have been revealed. It is reasonable to consider that awake animal experiments are more ideal for understanding naturalistic brain function than anesthetized ones. However, the anesthetized animal experiment still has advantages in some experiments. To take advantage of the anesthetized animal …

Structures Of Channelrhodopsin Paralogs In Peptidiscs Explain Their Contrasting K+ And Na+ Selectivities, Shu Kikuta, Shin Nagayama, Sanae Hasegawa-Ishii

Faculty, Staff and Student Publications

The olfactory epithelium (OE) is directly exposed to environmental agents entering the nasal cavity, leaving OSNs prone to injury and degeneration. The causes of olfactory dysfunction are diverse and include head trauma, neurodegenerative diseases, and aging, but the main causes are chronic rhinosinusitis (CRS) and viral infections. In CRS and viral infections, reduced airflow due to local inflammation, inflammatory cytokine production, release of degranulated proteins from eosinophils, and cell injury lead to decreased olfactory function. It is well known that injury-induced loss of mature OSNs in the adult OE causes massive regeneration of new OSNs within a few months through …

Role Of A Pdlim5:Palmd Complex In Directing Dendrite Morphology, Yogesh Srivastava, Maxsam Donta, Lydia L Mireles, Adriana Paulucci-Holthauzen, M Neal Waxham, Pierre D Mccrea

Faculty, Staff and Student Publications

Neuronal connectivity is regulated during normal brain development with the arrangement of spines and synapses being dependent on the morphology of dendrites. Further, in multiple neurodevelopmental and aging disorders, disruptions of dendrite formation or shaping is associated with atypical neuronal connectivity. We showed previously that Pdlim5 binds delta-catenin and promotes dendrite branching. We report here that Pdlim5 interacts with PalmD, a protein previously suggested by others to interact with the cytoskeleton (e.g.,

Anticancer Effects Of Wild Baicalin On Hepatocellular Carcinoma: Downregulation Of Akr1b10 And Pi3k/Akt Signaling Pathways, Longjun Sun, Wenjuan Chen, Peixi Zhao, Bin Zhao, Guangyan Lei, Le Han, Yili Zhang

Faculty, Staff and Student Publications

ntroduction

Hepatocellular carcinoma (HCC) is a common and deadly malignancy. Traditional Chinese medicine, such as the compound Astragalus (wild Baicalin), has shown promise in improving outcomes for HCC patients. This study aimed to investigate the effects of wild Baicalin on the human hepatoma cell line HepG2 and elucidate the underlying mechanisms, particularly the role of the AKR1B10 and PI3K/AKT signaling pathways.

Methods

HepG2 cells were treated with varying concentrations of wild Baicalin. Cell proliferation, apoptosis, migration, invasion, and cell cycle were evaluated using CCK-8, flow cytometry, scratch, Transwell, and clonogenic assays, respectively. Transcriptome sequencing was performed to analyze gene expression …

Rectifying Harm Through Care-Based Practices: How Journalists Might Tend To Disengaged Communities, Sue Robinson, Patrick R. Johnson

College of Communication Faculty Research and Publications

Journalists struggle to engage with disengaged communities, especially conservative and BIPOC groups. In this research, we suggest that an ethic of care, born from developmental psychology, can be a strategy for trust building. Using a multi-phased, multi-method approach through interviews, surveys, and a focus group, we found that community members believe journalists must be more careful and intentional with cultural and political language relating to ideology, racial identity, and sexual orientation. This study shows that journalists must address harm by contending with negative news experiences, nuancing labels and language associated with their communities, and adopting a combination of five care-based …

Simultaneous Submission Of Seven Ctsa Proposals: Um1, K12, R25, T32-Predoctoral, T32-Postdoctoral, And Rc2: Strategies, Evaluation, And Lessons Learned, Carolina Lema, Kwai Wa Cheng, Delanderia M Anderson, Charles C Miller, Daniel D Karp, David D Mcpherson, Satya Sree N Kolar

Faculty, Staff and Student Publications

Translation is the process of turning observations in the research laboratory, clinic, and community into interventions that improve people's health. The Clinical and Translational Science Awards (CTSA) program is a National Center for Advancing Translational Sciences (NCATS) initiative to advance translational science and research. Currently, 64 "CTSA hubs" exist across the nation. Since 2006, the Houston-based Center for Clinical Translational Sciences (CCTS) has assembled a well-integrated, high-impact hub in Texas that includes six partner institutions within the state, encompassing ∼23,000 sq. miles and over 16 million residents. To achieve the NCATS goal of "more treatments for all people more quickly," …

“Just Holding That Space”: Using Culturally Relevant Pedagogy To Create Counterspaces For Black College Students In Aanapisi/Hsi Classrooms, Nicholas B. Lacy, Yea-Wen Chen, Damariyé L. Smith

Journal of Communication Pedagogy

Black college students continue to face the specter of anti-Blackness which creates additional barriers to success and flourishing in higher education. This study investigates how instructors in higher education can provide racial equity to Black students in AANAPISI/HSI classrooms through counterspaces. We use culturally relevant pedagogy to investigate the experiences of 21 Black college students at an AANAPISI/HSI to understand better how higher education instructors can utilize counterspaces, places where Black college students can challenge dominant discourses and create a collegial learning environment. We identified three counterspace themes: (1) Mitigate Eurocentric Pedagogy, (2) Employ Black and Critical Scholarship, and (3) …

You Don’T Have To Be Their Best Friend: Complicating The Instructor-Student Relationship Through A Mixed-Method Typology, Jessalyn I. Vallade, Kyle Rudick

Journal of Communication Pedagogy

The purpose of this study was to explore the nuances of instructor-student relationships with a nationally representative sample of students. Participants were randomly assigned to describe relationships with their best, worst, and/or last instructor and rate their satisfaction with each relationship, and the level of closeness with the instructor. Coding of student descriptions revealed 13 themes, organized into six pairs of constructive/destructive relationship anchors and one neutral category (Professional Relationship). Importantly, professional relationships were not as close as constructive relationships but were equally satisfying, indicating the closeness in instructor-student relationships has diminishing returns. Results are discussed in the context of …

Ethics In Literature: A Case Study Of Hades And Persephone, Mckenzie A. Howard

College of Graduate Studies: Theses & Dissertations

The increased ethical scrutiny on art in the modern era places an emphasis on how those art forms are being taught in the classroom. This thesis seeks to answer the question: how do we teach ethics, if we should at all, when we teach literature to a modern audience? This thesis explores this question by looking at how modern adaptations of an ancient text, the “Hymn to Demeter,” change the ethical issues in the original text, to show the relevance of these issues in the source text and the modern adaptations. Through an argument that the ethical concerns are often …

Encapsulating Scars, Ashley Smith

College of Graduate Studies: Theses & Dissertations

My work explores scars through encapsulation, a desire to enclose and express the emotional scars of memories or physical scars of the body. Life’s experiences impact the living, leaving behind scars that we feel the need to understand. Through the mediums of metal and mixed-media photography, I utilize found and created imagery, as well as a triality of text in order to preserve and remember these scars.

Religious Iconography, Expressionist Lighting, And The Antihero's Spiritual Journey In Marvel's Daredevil, Savannah L. Pruett

College of Graduate Studies: Theses & Dissertations

In Marvel’s Daredevil (2015), Matthew Murdock undergoes different phases of an antiheroic spiritual journey as his faith in the judicial system and his Maker is tested by evil in Hell’s Kitchen, New York City. This thesis will dig deeper to reveal how the Daredevil series uses purposefully designed religious iconography and expressionist lighting to tell the story of Matthew Murdock’s antiheroic spiritual journey across three seasons. This thesis aims to prove that Daredevil is a complex and thought-provoking franchise that analyzes what it means to be an antihero, including the moral and ethical lines one is willing to cross to …

Examining The Relationship Between Puberty And Trauma Symptomatology, Justina M. Harsche

College of Graduate Studies: Theses & Dissertations

This study sought to examine the relation between puberty and trauma symptomatology in young adults. More specifically, does it matter what developmental period one is in when trauma occurs? Additionally, geographical region was examined as it relates to receiving and reporting mental health services and later trauma symptoms. Using data from 362 students at Georgia Southern University, multiple analyses were conducted. A Moderation Analysis where adverse events served as the predictor, trauma symptomatology as the outcome variable, and the developmental period in which the trauma occurred as the moderator was conducted. The interactions for this hypothesis were not significant. However, …

Computer Cravings In 20th Century Schools: From Creativity To Capitalism, Keely E. Amos

College of Graduate Studies: Theses & Dissertations

This dissertation examines the push for computers in education from the early 1980s to the early 2000s. During that time, computers were introduced into schools across America with big promises, in turn creating big dreams. Instead of the cognition, creativity, and collaboration that was envisioned with computers in the classroom, the shifting motivations regarding computers have exacerbated the datafication and standardization of our students (Cuban, 2001). The problems associated with the corporation of computers into the curriculum are widespread (Pinar et. al, 1995/2004). Following the methodology of Historiography, this paper provides a critical examination about what was promised, and by …

Chronic Training Load And Dorsiflexion Range Of Motion Throughout A Season In Professional American Soccer, Tristan L. Young

College of Graduate Studies: Theses & Dissertations

Soccer has an incredibly complex movement profile. Players experience various types of strains on their body from the requirement to land in awkward positions while maintaining the ability to quickly accelerate and decelerate. Dorsiflexion range of motion (DFROM) is of concern due to the movement profile and ball control that requires constant eccentric and concentric actions at the talocrural joint. With an American soccer season spanning across nine months these demands can contribute to overuse, which has been linked to restricted range of motion. Restricted DFROM and asymmetries have been identified as injury predictors, but their relationship to performance has …

Performing Holt-Winters Time Series Forecasting Using Neural Network Based Models, Kazeem Olanrewaju Bankole

College of Graduate Studies: Theses & Dissertations

We show how to create Artificial Neural Network based models for performing the well- known Holt-Winters time series analysis. Our work fares well compared to the well-known Holt-Winter time series prediction method while avoiding the burden of searching for the parameters of the model. We present the theoretical justification of the connection between the two models and experimental results showing the similarities of these models

Exploring Police K-9 Deaths, Their Causes, And Possible Remedies, John Wise

College of Graduate Studies: Theses & Dissertations

Police K-9s face daily dangers due to their work. Data collected by the Officer Down Memorial Page from 2000-2023 on K-9 deaths (N = 405) shows that of K-9s that die in the line of duty, many fall victim to heat stroke. Research was conducted comparing heat stroke to all other causes of death. Through an exploration into the history of mankind’s use of working dogs, the unique capabilities of both dogs and K-9 specific dog breeds and applying Routine Activity Theory and Lifestyle Routine Activity Theory to police K-9s, this study’s objective is to bring awareness to, and …

Bringing Gans To Medieval Times: Manuscript Translation Models, Tonilynn M. Holtz

College of Graduate Studies: Theses & Dissertations

The Generative Adversarial Networks (GAN) recently emerged as a powerful framework for producing new knowledge from existing knowledge. These models aim to learn patterns from input data then use that knowledge to generate output data samples that plausibly appear to belong to the same set as the input data. Medieval manuscripts study has been an important research area in the humanities field for many decades. These rare manuscripts are often times inaccessible to the general public, including students in scholars, and it is of a great interest to provide digital support (including, but not limited to translation and search) for …

The U.S. Southern Mothers Perspective On Affection, Destiny M. Rose

College of Graduate Studies: Theses & Dissertations

This qualitative research study utilizes Murray Bowen’s Family Systems Theory and Kimberlé Crenshaw’s Intersectionality Theory to examine how ten mothers residing in what is identified as the U.S. Deep South (Georgia, Alabama, and South Carolina) perceive affection shown to their children by adults outside of their nuclear family. Additionally, this study considers the influence social class plays in how parents in the Deep South navigate and negotiate social and cultural norms when it comes to affection displays shown to their children. Data was collected using thematic analysis to describe how parents in parts of the Deep South perceive affection shown …