Digital Commons Network^™

Teaching Matters In Formula Preparation-A Measure Of Equity And Nutritional Safety, Matthew D. Di Guglielmo

Department of Pediatrics Faculty Papers

No abstract provided.

Birthday Girl, Makayla Tappin

Master's Projects

The lives of four friends plummet into chaos after a dead friend from college seemingly resurfaces – alive.

Built For Two, David Miller

Master's Projects

Built for Two is an original romantic comedy screenplay that I wrote during my time at Kennesaw State University.

Adiposity Throughout Adulthood And Risk Of Young-Onset Breast Cancer Tumor Subtypes In The Young Women's Health History Study, Lydia Marcus Post, Dorothy R. Pathak, Ann S. Hamilton, Kelly A. Hirko, Richard T. Houang, Emily H. Guseman, Dan Sanfelippo, Nicole Bohme Carnegie, L. Karl Olson, Hallgeir Rui, Ann G. Schwartz, Ellen M. Velie

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

BACKGROUND: The role of adult adiposity in young-onset breast cancer (YOBC) subtype risk is not well understood.

METHODS: In this population-based case (n = 1812)-control (n = 1,381) study of invasive YOBC (ages <50 >years), cases were identified from the Los Angeles County and Metropolitan Detroit Surveillance, Epidemiology, and End Results registries, 2010 to 2015. Area-based, frequency-matched controls were sampled from the 2010 Census. General adiposity [body mass index (BMI)] and central adiposity (waist circumference and waist-to-height ratio) across adulthood and covariates were collected from in-person interviews and measurements. ORs and 95% confidence intervals (CI) for adiposity and YOBC tumor subtypes …

Perceptions Of Parents And Guardians Regarding Home-To-School Involvement, Brie Merritt

Walden Dissertations and Doctoral Studies

The problem that was addressed through this study was the decline in home-to-school partnerships within a local, public, and ethnically diverse middle school (DMS) in the Southeastern United States. The purpose of this qualitative study was to explore parents’ perspectives on the decline in home-to-school partnerships at a DMS. Using Epstein’s six types of family involvement as a guide, a qualitative, exploratory design was used, with data collected through semi structured interviews with 12 Black mothers of eighth-grade students from DMS in the 2022–2023 school year. Braun and Clarke’s thematic analysis revealed the following four themes: communication satisfaction, parent-school engagement, …

Exploring Successful Employee Retention Strategies In The Distribution Warehouse Industry, Meriam Sunday

Walden Dissertations and Doctoral Studies

Low employee engagement often leads to employee dissatisfaction, reduced morale, and employee turnover. Frontline distribution warehouse managers who struggle to engage employees risk retention challenges. Grounded in Herzberg’s two-factor theory and Maslow’s hierarchy of needs theory, the purpose of this qualitative pragmatic inquiry was to explore employee engagement strategies frontline distribution warehouse managers use to increase retention. The participants were six frontline distribution warehouse managers who had successfully implemented employee engagement strategies and increased employee retention. Data were collected using semistructured interviews, public websites, public documents, current and archival. Using thematic analysis, four themes were identified: (a) effective leadership and …

Exploring Successful Employee Retention Strategies In The Distribution Warehouse Industry, Meriam Sunday

Walden Dissertations and Doctoral Studies

Low employee engagement often leads to employee dissatisfaction, reduced morale, and employee turnover. Frontline distribution warehouse managers who struggle to engage employees risk retention challenges. Grounded in Herzberg’s two-factor theory and Maslow’s hierarchy of needs theory, the purpose of this qualitative pragmatic inquiry was to explore employee engagement strategies frontline distribution warehouse managers use to increase retention. The participants were six frontline distribution warehouse managers who had successfully implemented employee engagement strategies and increased employee retention. Data were collected using semistructured interviews, public websites, public documents, current and archival. Using thematic analysis, four themes were identified: (a) effective leadership and …

Exploring Successful Employee Retention Strategies In The Distribution Warehouse Industry, Meriam Sunday

Walden Dissertations and Doctoral Studies

Low employee engagement often leads to employee dissatisfaction, reduced morale, and employee turnover. Frontline distribution warehouse managers who struggle to engage employees risk retention challenges. Grounded in Herzberg’s two-factor theory and Maslow’s hierarchy of needs theory, the purpose of this qualitative pragmatic inquiry was to explore employee engagement strategies frontline distribution warehouse managers use to increase retention. The participants were six frontline distribution warehouse managers who had successfully implemented employee engagement strategies and increased employee retention. Data were collected using semistructured interviews, public websites, public documents, current and archival. Using thematic analysis, four themes were identified: (a) effective leadership and …

Comparative Analysis Of Indices For Social Determinants Of Health In Pediatric Surgical Populations, Caroline Q Stephens, Ava Yap, Lan Vu, Jacqueline M Saito, Dwight Barry, Amy M Shui, Hannah Cockrell, Sarah Cairo, Derek Wakeman, Loren Berman, Sarah Greenberg, Allison F Linden, Jonathan Kohler, Kuojen Tsao, Nicole A Wilson

Faculty, Staff and Student Publications

Importance: Conclusions vary substantially among studies examining associations between area-based social determinants of health (SDOH) and pediatric health disparities based on the selected patient population and SDOH index. Most national studies use zip codes, which encompass a wide distribution of communities, limiting the generalizability of findings.

Objectives: To characterize the distributions of composite SDOH indices for pediatric surgical patients within a national sample of academic children's hospitals and to assess SDOH index precision in classifying patients at similar levels of disadvantage.

Design, setting, and participants: This multicenter retrospective cohort study included patients younger than 18 years who underwent surgery from …

Game Of Chance, Lily Kate Anthony

Electronic Theses and Dissertations Archive

“Game of Chance” features a purportedly psychic protagonist, Lucy Cartwright, who works as a tarot card reader online and in public forums. After a series of toxic relationships and a lifetime of watching her mother’s relationships fail, Lucy is initiated into the world of tarot and Twin Flames by a fraudulent psychic named Christine. While romantic pressure from her culture and peers mounts, Lucy resorts to spellwork to manifest her Twin and then meets Chance, an optometry student and amateur gambler who falls for her quickly. The fragility of their connection is revealed when Lucy panics at contradictions in the …

Negation As Cue During Semantic Learning, David Aaron Heath

Electronic Theses and Dissertations Archive

Word learning begins by mapping novel words to referents in the world. Over time, this mapping becomes a reliable semantic representation with semantic relationships to other words. A major contributor to the strength of semantic relationships is context. We explored the extent to which purely linguistic context can influence semantic relationships. We used an artificial language learning task combined with the visual world paradigm to assess the degree of coactivation between yoked items. Participants learned novel words for familiar images in yoked pairs. We manipulated the linguistic context during training trials by presenting the novel words with a negation or …

Passion Plays And Their Touristic Utilisation: Authenticity Or Commercialisation?, Dimitrios Mylonopoulos, Polyxeni Moira, Elli Terzoglou

International Journal of Religious Tourism and Pilgrimage

Tourism development and the economic benefits that come from tourism have led to the increase and revival of religious celebrations and festivals in the form of events and performances, especially during the Holy Week. Many events such as Passion Plays of Jesus, due to their enduring existence in time, ‘authenticity’, particularities, originality and the emotions they evoke, capture the attention of both religious people and tourists. These Passion Plays are specific religious-cultural events that consist of depictions of scenes from Jesus Christ’s passion, following the biblical narrations (e.g. the Teaching, the Passion, the Crucifixion, the Resurrection). According to UNESCO (2014), …

Impact Analysis Of Religious Events: Medjugorje As A Pilgrimage Destination, Igor Stamenkovic, Ivan Dodig, Dajana Vukojević

International Journal of Religious Tourism and Pilgrimage

Medjugorje is one of the most well-known and attractive pilgrimage sites for Roman Catholics. The phenomenon of Medjugorje is linked to the apparitions of the Blessed Virgin Mary to six children, which, according to the children’s claims, began in June 1981, after which this town has become one of the most visited destinations in the whole of Bosnia and Herzegovina. Tens of thousands of pilgrims attend the International Youth Festival “Mladifest”, a religious gathering that has been going on for more than thirty years. The purpose of this paper is to research and explain how this religious event impacts a …

Increasing The Attractiveness Of Hungarian Religious Pilgrimage Routes, The Case Of Rurallure, Ákos Lencsés, Ildikó Kádárné Kelemen, Ildikó Csepregi, Zsófia Galgócziné Szabó

International Journal of Religious Tourism and Pilgrimage

The paper discusses the regional variations and attractiveness of pilgrimage routes in Europe, focusing on the Way of Mary. The Horizon Europe project rurAllure aims to use innovative techniques, such as narrative techniques of cultural heritage and mapping non-religious points of interests, to expand the area around the route and attract younger and spiritually-seeking pilgrims. The study introduces the selection criteria, workflow, and technologies used to enhance the tourism experience along the route, exploring alternative route variants and narrative creating techniques. For this, we describe and analyse the data of Points of Interest (POIs), narratives, and recommended trips generated as …

A Review On Ethnomedical Use Of Tephrosia Vogelii Hook.F. And Its Potentiality Towards The Development Of Antimicrobial Agents And Pesticides, Stephano Hanolo Mlozi, Juma Mmongoyo, Musa Chacha

Tanzania Journal of Science

Fish bean, Tephrosia vogelii Hook.f is among of potential medicinal plant species in the genus Tephrosia. It has been traditionally used to cure human and animal ailments including fungal and bacterial diseases though not exhaustively scientifically reported. Similarly, its extracts have been locally used to control vectors and pests in small scale farming though the drug development from its extracts and phytochemicals is not reported. Thus, this review focused to unveil its ethnomedical and pharmaceutical potentiality with emphasis towards development of antimicrobial agents and pesticides. Data collection for the review was based on the published paper searched globally in several …

Perceptions Of Teachers Regarding The Low Biliteracy Scores Of Fifth Grade Emergent Bilinguals In A Dual Language Program, Maria Ines Trevino

Walden Dissertations and Doctoral Studies

The problem addressed in this study was that at Nepantla Independent School District (pseudonym) bilingual fifth grade students have not attained biliteracy goals in their dual language program. The purpose of this qualitative study was to analyze the dual language teachers’ perceptions regarding fifth grade emergent bilingual students’ low levels of biliteracy proficiency and the challenges seen as hindering students’ opportunities to master the dual language program's biliteracy goals. The framework encompassed Krashen, Cummins, Thomas and Collier’s theories which explore language acquisition, learning and bilingual education. The research questions explored the extent to which dual language instructors perceived the inadequate …

Excess Mortality In Persons With Concurrent Hiv And Cancer Diagnoses: A Retrospective Cohort Study, Kamaria L Lee, Varada Sarovar, Jennifer O Lam, Wendy A Leyden, Stacey E Alexeeff, Alexandra N Lea, Rulin C Hechter, Haihong Hu, Julia L Marcus, Qing Yuan, Jennifer R Kramer, Lilie L Lin, Elizabeth Y Chiao, William J Towner, Michael A Horberg, Michael J Silverberg

Center for Medical Ethics and Health Policy Staff Publications

Background: With extended lifespans for people with human immunodeficiency virus (PWH), there is a corresponding increased burden of chronic illnesses, including cancer. Our objective was to estimate the excess mortality among PWH with cancer compared with people without HIV (PWoH), accounting for the higher background mortality in the general PWH population.

Methods: We identified 39,000 PWH and 387,767 demographically matched PWoH in three integrated healthcare systems from 2000 to 2016. We estimated excess mortality among PWH with cancer, computed as the cancer mortality rate difference-in-difference comparing PWH and PWoH. We evaluated five cancer groups: any cancer; virus-, human papillomavirus-, and …

Individualized Functional Magnetic Resonance Imaging Neuromodulation Enhances Visuospatial Perception: A Proof-Of-Concept Study, Anthony Allam, Vincent Allam, Sandy Reddy, Eric M Rohren, Sameer A Sheth, Emmanouil Froudarakis, T Dorina Papageorgiou

Duncan NRI Faculty and Staff Publications

This proof-of-concept study uses individualized functional magnetic resonance imaging neuromodulation (iNM) to explore the mechanisms that enhance BOLD signals in visuospatial perception (VP) networks that are crucial for navigation. Healthy participants (n = 8) performed a VP up- and down-direction discrimination task at full and subthreshold coherence through peripheral vision, and superimposed direction through visual imagery (VI) at central space under iNM and control conditions. iNM targets individualized anatomical and functional middle- and medial-superior temporal (MST) networks that control VP. We found that iNM engaged selective exteroceptive and interoceptive attention (SEIA) and motor planning (MP) networks. Specifically, iNM increased …

Improving Prognostication In Hypoxic-Ischemic Encephalopathy, Daniel G Calame, Kristen S Fisher

Faculty, Staff and Students Publications

No abstract provided.

Pediatric Covid-19 Vaccine Hesitancy Among Pregnant And Post-Partum Women: A Mixed-Method Study, Tasmiah Nuzhath, Brian Colwell, Timothy Callaghan, Peter Hotez, Sabrina Mousum, Ummul Wara Masud, Annette K Regan

Faculty, Staff and Students Publications

Background: This study aims to understand factors contributing to pediatric COVID-19 vaccine hesitancy among pregnant and postpartum adults.

Method: The study used targeted intercept advertising on Facebook, Twitter, and Instagram to recruit a panel of 3600 pregnant and postpartum US adults. Data were collected between December 2021 and April 2022 (i.e., before the introduction of pediatric COVID-19 vaccines in the U.S.). We used logistic regression to understand factors associated with pregnant and postpartum women's hesitancy towards getting children < 5 vaccinated against COVID-19. Poststratification weights were applied to analyses to promote the representativeness of the sample. We also conducted a qualitative thematic analysis to determine the reasons for pediatric vaccine hesitancy.

Results: Nearly half (45.6 %) of pregnant or postpartum women were hesitant to vaccinate their child against COVID-19. Vaccine hesitancy was lower …

Chlorthalidone Vs Hydrochlorothiazide And Kidney Outcomes In Patients With Hypertension: A Secondary Analysis Of A Randomized Clinical Trial, Areef Ishani, Cynthia Hau, Srihari Raju, Jessica K Wise, Peter A Glassman, Addison A Taylor, Ryan E Ferguson, William C Cushman, Sarah M Leatherman

Faculty, Staff and Students Publications

Importance: Hypertension is a risk factor for the development and progression of chronic kidney disease (CKD). It is unclear whether different thiazide diuretics have a differential impact on kidney outcomes.

Objective: To compare kidney outcomes in patients with hypertension taking chlorthalidone and hydrochlorothiazide.

Design, setting, and participants: This prespecified secondary analysis of the Diuretic Comparison Project, a randomized clinical trial comparing chlorthalidone and hydrochlorothiazide for the treatment of hypertension, was conducted between June 1, 2016, and June 1, 2022, through Veterans Affairs facilities nationwide. This analysis extended follow-up to December 31, 2023. Veterans 65 years or older with hypertension who …

Onset And Progression Of Disease In Nonhuman Primates With Pde6c Cone Disorder, Monica Ardon, Lily Nguyen, Rui Chen, Jeffrey Rogers, Tim Stout, Sara Thomasy, Ala Moshiri

Faculty, Staff and Students Publications

PURPOSE: The California National Primate Research Center contains a colony of rhesus macaques with a homozygous missense mutation in PDE6C (R565Q) which causes a cone disorder similar to PDE6C achromatopsia in humans. The purposes of this study are to characterize the phenotype in PDE6C macaques in detail to determine the onset of the cone phenotype, the degree to which the phenotype progresses, if heterozygote animals have an intermediate phenotype, and if rod photoreceptor function declines over time.

METHODS: We analyzed spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), and electroretinography (ERG) data from 102 eyes of 51 macaques (aged 0.25 …

Urinary Metal Levels, Cognitive Test Performance, And Dementia In The Multi-Ethnic Study Of Atherosclerosis, Arce Domingo-Relloso, Katlyn E Mcgraw, Susan R Heckbert, Jose A Luchsinger, Kathrin Schilling, Ronald A Glabonjat, Irene Martinez-Morata, Melanie Mayer, Yongmei Liu, Alexis C Wood, Jeff Goldsmith, Kathleen M Hayden, Mohamad Habes, Ilya M Nasrallah, R Nick Bryan, Tanweer Rashid, Wendy S Post, Jerome I Rotter, Priya Palta, Linda Valeri, Timothy M Hughes, Ana Navas-Acien

Faculty, Staff and Students Publications

IMPORTANCE: Metals are established neurotoxicants, but evidence of their association with cognitive performance at low chronic exposure levels is limited.

OBJECTIVE: To investigate the association of urinary metal levels, individually and as a mixture, with cognitive tests and dementia diagnosis, including effect modification by apolipoprotein ε4 allele (APOE4).

DESIGN, SETTING, AND PARTICIPANTS: The multicenter prospective cohort Multi-Ethnic Study of Atherosclerosis (MESA) was started from July 2000 to August 2002, with follow-up through 2018. A total of 6303 MESA participants were included. Data analysis was performed from October 12, 2023, to June 13, 2024.

EXPOSURE: Urine samples were collected at baseline …

Neurofeedback: New Territories And Neurocognitive Mechanisms Of Endogenous Neuromodulation, James Sulzer, T Dorina Papageorgiou, Rainer Goebel, Talma Hendler

Faculty, Staff and Students Publications

Neurofeedback (NF) is endogenous neuromodulation of circumscribed brain circuitry. While its use of real-time brain activity in a closed-loop system is similar to brain-computer interfaces, instead of controlling an external device like the latter, the goal of NF is to change a targeted brain function. In this special issue on NF, we present current and future methods for extracting and manipulating neural function, how these methods may reveal new insights about brain function, applications, and rarely discussed ethical considerations of guiding and interpreting the brain activity of others. Together, the articles in this issue outline the possibilities of NF use …

Extreme Wrinkling Of The Nuclear Lamina Is A Morphological Marker Of Cancer, Ting-Ching Wang, Christina R Dollahon, Sneha Mishra, Hailee Patel, Samere Abolghasemzade, Ishita Singh, Vilmos Thomazy, Daniel G Rosen, Vlad C Sandulache, Saptarshi Chakraborty, Tanmay P Lele

Faculty, Staff and Students Publications

Nuclear atypia is a hallmark of cancer. A recent model posits that excess surface area, visible as folds/wrinkles in the lamina of a rounded nucleus, allows the nucleus to take on diverse shapes with little mechanical resistance. Whether this model is applicable to normal and cancer nuclei in human tissues is unclear. We image nuclear lamins in patient tissues and find: (a) nuclear laminar wrinkles are present in control and cancer tissue but are obscured in hematoxylin and eosin (H&E) images, (b) nuclei rarely have a smooth lamina, and (c) wrinkled nuclei assume diverse shapes. Deep learning reveals the presence …

The Study Of The Epidemiology Of Pediatric Hypertension Registry (Superhero): Rationale And Methods, Andrew M South, Victoria C Giammattei, Kiri W Bagley, Christine Y Bakhoum, William H Beasley, Morgan B Bily, Shupti Biswas, Aaron M Bridges, Rushelle L Byfield, Jessica Fallon Campbell, Rahul Chanchlani, Ashton Chen, Lucy D'Agostino Mcgowan, Stephen M Downs, Gina M Fergeson, Jason H Greenberg, Taylor A Hill-Horowitz, Elizabeth T Jensen, Mahmoud Kallash, Margret Kamel, Stefan G Kiessling, David M Kline, John R Laisure, Gang Liu, Jackson Londeree, Caroline B Lucas, Sai Sudha Mannemuddhu, Kuo-Rei Mao, Jason M Misurac, Margaret O Murphy, James T Nugent, Elizabeth A Onugha, Ashna Pudupakkam, Kathy M Redmond, Sandeep Riar, Christine B Sethna, Sahar Siddiqui, Ashley L Thumann, Stephen R Uss, Carol L Vincent, Irina V Viviano, Michael J Walsh, Blanche D White, Robert P Woroniecki, Michael Wu, Ikuyo Yamaguchi, Emily Yun, Donald J Weaver

Faculty, Staff and Students Publications

Despite increasing prevalence of hypertension in youth and high adult cardiovascular mortality rates, the long-term consequences of youth-onset hypertension remain unknown. This is due to limitations of prior research, such as small sample sizes, reliance on manual record review, and limited analytic methods, that did not address major biases. The Study of the Epidemiology of Pediatric Hypertension (SUPERHERO) is a multisite, retrospective registry of youth evaluated by subspecialists for hypertension disorders. Sites obtain harmonized electronic health record data using standardized biomedical informatics scripts validated with randomized manual record review. Inclusion criteria are index visit for International Classification of Diseases, 10th …

Inherited Retinal Degenerations And Non-Neovascular Age-Related Macular Degeneration: Progress And Unmet Needs, Jacque L Duncan, Angela Bowman, Amy Laster, Claire Gelfman, David G Birch, Shannon E Boye, Stephen P Daiger, Lucian Del Priore, Donald J Zack, James T Handa

Faculty, Staff and Student Publications

Inherited retinal degeneration (IRD) disease and age-related macular degeneration (AMD) are leading causes of irreversible vision loss and blindness. Although significant progress has advanced the field in the past 5 years, significant challenges remain. The current article reviews the accomplishments and research advances that have fueled the development of treatments for patients with IRD and AMD, including the first approved gene-augmentation treatment for RPE65-related retinal degeneration and complement inhibition therapies to slow progression of geographic atrophy (GA) in AMD. The article outlines opportunities to address gaps and unmet needs that should lead to additional progress toward the development of treatments …

Systemic Administration Of A Site-Targeted Complement Inhibitor Attenuates Chronic Stress-Induced Social Behavior Deficits And Neuroinflammation In Mice, Amit Kumar Madeshiya, Brandi Quintanilla, Carl Whitehead, Stephen Tomlinson, Anilkumar Pillai

Faculty, Staff and Student Publications

Chronic stress, a risk factor for many neuropsychiatric conditions, causes dysregulation in the immune system in both humans and animal models. Additionally, inflammation and synapse loss have been associated with deficits in social behavior. The complement system, a key player of innate immunity, has been linked to social behavior impairments caused by chronic stress. However, it is not known whether complement inhibition can help prevent neuroinflammation and behavioral deficits caused by chronic stress. In this study, we investigated the potential of a site-targeted complement inhibitor to ameliorate chronic stress-induced changes in social behavior and inflammatory markers in the prefrontal cortex …

Artificial Intelligence (Ai)-Powered Bibliometric Analysis Of Global Trends In Mesenchymal Stem Cells (Mscs)-Derived Exosome Research: 2014-2023, Shih-Chang Tsai, Bing-Han Wan, Fuu-Jen Tsai, Jai-Sing Yang

BioMedicine

Introduction: In recent years, significant progress has been made in regenerative medicine, specifically in using mesenchymal stem cells (MSCs) due to their regenerative and differentiating abilities. An exciting development in this area is the utilization of exosomes derived from MSCs, which have shown promise in tissue restoration, immune system modulation, and cancer treatment.

Objectives: This study aims to analyze global research trends and the academic impact of MSCs-derived exosomes from 2014 to 2023, providing a comprehensive overview of this emerging field.

Materials and Methods: The Web of Science database selected 948 relevant publications from 2014 to 2023. Artificial intelligence …

Restorative Pedagogy To Build Community In The Classroom: Autoethnographic Reflections From Faculty, Sheila M. Mcmahon, Zahra Ahmed, Michelle Bemiller

International Journal of Teaching and Learning in Higher Education

Restorative justice (RJ) is a philosophy and set of practices that center harms and needs. Within a classroom setting, an RJ pedagogical approach invites a process of shared learning that attends to critical issues of equity, power, and voice. Utilizing an autoethnographic approach, this manuscript includes critical reflections from three faculty members from diverse disciplines and positionalities about the use of RJ approaches to teaching in our respective classrooms. This paper includes discussion about the intersection of RJ with critical pedagogy, power differentials, and pragmatic issues of classroom structure learning design.