Digital Commons Network^™

Role Of Nf2 Mutation In The Development Of Eleven Different Cancers, Shervin Hosseingholi Nouri, Vijay Nitturi, Elizabeth Ledbetter, Collin W English, Sean Lau, Tiemo J Klisch, Akash J Patel

Faculty, Staff and Students Publications

Background/Objectives: With the rise in prevalence of diagnostic genetic techniques like RNA sequencing and whole exome sequencing (WES), as well as biological treatment regiments for cancer therapy, several genes have been implicated in carcinogenesis. This review aims to update our understanding of the Neurofibromatosis 2 (NF2) gene and its role in the pathogenesis of various cancers. Methods: A comprehensive search of five online databases yielded 43 studies that highlighted the effect of sporadic NF2 mutations on several cancers, including sporadic meningioma, ependymoma, schwannoma, mesothelioma, breast cancer, hepatocellular carcinoma, prostate cancer, glioblastoma, thyroid cancer, and melanoma. Of note were key biological …

Vaccines Targeting P53 Mutants Elicit Anti-Tumor Immunity, Dafei Chai, Xu Wang, Chunmei Fan, Junhao Wang, Jing Ming Lim, Xinfang Yu, Ken H Young, Yong Li

Faculty, Staff and Students Publications

The p53 tumor suppressor is commonly mutated in cancer; however, there are no effective treatments targeting p53 mutants. A DNA vaccine gWIZ-S237G targeting the p53 S237G mutant, which is highly expressed in A20 murine tumor cells, was developed and administered intramuscularly via electroporation, either alone or in combination with PD1 blockade. The anti-p53-S237G immunization elicited a robust protective response against subcutaneous A20 tumors and facilitated the infiltration of immune cells including CD8+ T cells, NK cells, and DCs. The vaccine enhanced the induction and maturation of CD11c+, CD103+CD11c+, and CD8+CD11c+ cells, which in turn promoted tumor-specific antibody production, as well …

Chiropterophagy By The Siberian Weasel (Mustela Sibirica): The First Record In The Russian Far East, Valeriya E. Omelko, Mikhail P. Tiunov

International Journal of Speleology

Chiropterophagy is a widespread phenomenon, but only one case of bat consumption by sable has been documented in the Russian Far East. This study presents the first recorded instance of chiropterophagy by the Siberian weasel (Mustela sibirica) in the southern Russian Far East, based on excrement collected from the Solyanik Cave in the southern Sikhote-Alin Mountains in 2007. The excrement included bones from three bat species (Murina hilgendorfi, Myotis bombinus, Plecotus ognevi) and one vole species (Myodes rutilus). Our findings suggest that the Siberian weasel visits caves during the cold season, although …

The Enactive Nature Of The Relationship Between Criticism And Aesthetics: From Practice To Theory To Pedagogy, Ivan Magrin-Chagnolleau

Presidential Fellows Articles and Research

This article delves into the intricate relationship between criticism and aesthetics, emphasizing its enactive nature. It explores how this relationship informs pedagogy and has culminated in the creation of an innovative undergraduate aesthetics course centered around the practice of writing critiques. Moreover, it illustrates the dynamic process through which practice gives rise to theory, subsequently influencing pedagogical approaches, and, intriguingly, circling back to practice. To elucidate this flow of ideas across the realms of practice, theory, and pedagogy, we introduce several key concepts. These include the paradigm of creation research, also known as practice as research, which forms the foundation …

Hauntings Of Publication Deaths, Possibilities For Our Academic Present, Kathleen (Kaye) A. Hare, Amber Moore

Journal of Feminist Scholarship

In this paper, we use a feminist dialogue to query publication deaths that haunt us. We ruminate on respective past publications that remain unread and uncited, despite encapsulating defining events in our development as scholars. For Author Kaye Hare this was an affective narrative that troubled a seemingly ideal moment of public scholarship; for Author Amber Moore, this was a hard-fought analysis of precarious intersectional feminist resistance in popular culture. Inspired by the horror-film genre “spectral incognizance,” we methodologically deploy a multivocal dialogical structure based on multiple revisitings that attenuate anxieties of metaphorical publication death, before revealing that this death …

Using Gis To Visualize Daily Routines At The Neighborhood And Household Scales: A Feminist Approach Using A Nineteenth-Century Diary, Sterling D. Quinn

Journal of Feminist Scholarship

Feminist scholars in the discipline of geography have noted the ways that routine activities at the household and neighborhood scales contribute to power relations and identity formation. Geographic information systems (GIS), with their ability to create multiple visual representations of people’s experiences in space at any scale, hold great potential for revealing these local processes and patterns that are often lost or invisible in broader historical narratives, especially when they pertain to women and children. This article contributes an example by using GIS to encode and map everyday events in a diary kept by Elisabeth Koren, a nineteenth-century Norwegian immigrant …

"They Don't Get It": Marginalized Mothers And Their Experiences With Social Support", Zuleida Herba

Counseling and Psychology Dissertations

Maternal caregivers of children with developmental disabilities (DD) experience a significant burden of care and increased parenting stress, making social support crucial to family well-being. This qualitative study used a feminist, intersectional framework to examine how marginalized mothers of children with DD, who have been less extensively studied than majority mothers (Stober & Franzese, 2018), perceive and experience social support from extended family, friends and community members. It also examined how social supports impact the mother’s quality of life, understanding that the caregiver's well-being is a determining factor for the child's well-being. The study investigated, from mothers’ perspectives, what kind …

From Vacant Lots To Paved Roads: Exploring West Whittier- Los Nietos, Marianne Edith Vazquez-Ochoa

Whittier City & College Historical Research

West Whittier- Los Neitos history of Latino in neighborhood like Jimtown in Whittier California

Real-World Safety Profile Of Therapy With Ibrutinib Or Acalabrutinib In Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Ramsay Hafer, Francesco Iadevaia, Thomas Z. Rohan, Teresa Duong, Maria Poluch, Gina Keiffer, Michael Li, Andres Ferber, Luca Laurenti, Alan Khoo, Pierluigi Porcu

Department of Medical Oncology Faculty Papers

No abstract provided.

Extracorporeal Shock Wave Therapy For Children And Adolescents Diagnosed With Osgood Schlatter Disease To Reduce Knee Pain: Systematic Review, Mohammad Tamboosi, Mohammad Tamboosi, Hashim Alharthi, Abdulaziz Bukhari Bukhari, Abdulrahman Alsulami, Waleed Hawari, Yazeed Alahmadi, Rayan Alshahrani, Rayan Alshamrani

Journal of Medical Rehabilitation Science

Aim: The current systematic review aimed to investigate the effectiveness of ESWT on children and adolescents diagnosed with OSD to reduce their knee pain. Method: An electronic search for studies about ESWT on patients with OSD that were published in English in different databases (CINAHL, PubMed, MEDLINE, Scopus, and PEDro). National Heart, Lung, and Blood Institute’s Quality assessment tool was used to evaluate the included studies. Results: According to the search strategy, from 2807 articles, only 2 studies (retrospective cohort and RCT) were selected for the current review, with a total of 34 subjects (20 Males and 14 Females) diagnosed …

Synergic Efficiency Of Organophosphonates In The Synthesis And Corrosion Inhibition Of Zinc Complexonates, Shoyunus Botir Ugli Obidov, Xusniddin Nurboboyevich Raximov, Xasan Irgashevich Kadirov, Satridin Maxamatdinovich Turabdjanov

Technical science and innovation

In this article, the processes of metal complex synthesis are studied in detail. Zinc OEDF+NTF complexation reactions were carried out in the presence of polyhydric alcohols, ethylene glycol, glycerol, and citric acid. For the first time, the synergistic efficiency of a mixture of zinc OEDF+NTF complexes with methyldiethanolamine, used as an inhibitor of mineral salt accumulation, was studied. It was found that when selecting the components in equivalent amounts, the inhibition efficiency of the composition is at least 90%. The high efficiency of inhibiting mineral salt accumulation in the composition is due to the presence of methyldiethanolamine, alkylimidazoline, and their …

Energy-Efficient Technologies For Drying Mulberry Silkworm Cocoons Using Infrared Radiation, Doston Ishmukhammat Ugli Samandarov

Technical science and innovation

The article presents the results of theoretical and experimental studies on drying of mulberry silkworm cocoons. Based on the analysis of drying efficiency and silk quality, the use of infrared radiation (IR) at a temperature of 70 °C was found to be optimal. The experimental data were tested on six mathematical models, among which the Midilli model most accurately described the drying process. The effective moisture diffusion coefficient was found to vary in the range of 1.847×10^-⁹-4.339×10^-⁹ m²/s, and the drying rate was found to be 0.32-0.79 kg of water/hour. IR radiation promotes accelerated evaporation of …

Bаsing Thе Sресifiс Сhаrасtеristiсs Оf Sаlinе Sоils Оn Thе Bаsis Оf Buildings Аnd Struсturеs In Thе Соnditiоns Оf Uzbеkistаn (Аs Аn Еxаmрlе Оf Thе Mirzасhоl Рlаins), Аbdubaki Djalilovich Kауumоv, Murad Kаmbаrоv, Olmos Zafarov, Zukhriddin Muradov, Islom Ilhom Ugli Ro‘Ziyev

Technical science and innovation

This article comprehensively examines the physical-mechanical and chemical properties of saline soils and their changes under the influence of moisture, as well as the impact of these changes on the foundations of buildings and structures. The study analyzes the variation of salinity levels over time due to prolonged water exposure and its effects on the stability and safety of structures, highlighting critical issues observed in regions of our country where saline soils are prevalent. Based on engineering-geological and hydrogeological research, solutions to minimize the consequences of salinity, determine soil deformation and strength characteristics, and ensure the safety of structures are …

Joint Assessment Of Characteristics Of Object Parameters And Statistical Characteristics Of Disturbing Influences, Yulduz Mukhtarkhodzhaevna Abdurakhmanova

Technical science and innovation

The paper considers the problem of joint estimation of object parameters and statistical characteristics of random disturbances based on data from independent experiments. It is indicated that the use of the method of moments for the problem under consideration gives estimates that are not effective in the Rao-Kramer sense and the most common asymptotically effective estimation method, in this sense, is the maximum likelihood method(ML). However, in the case of objects with several disturbances that have distribution densities of a general form, the implementation of the ML method is difficult, since to find the values of the distribution density it …

Mathematical Model Of Control Of A Pumping Unit Used In The Technological Process Of Wastewater Treatment, Nodira Batirdjanovna Alimova Dsc, Professor, Aziza Ruzimamamovna Khaitova

Technical science and innovation

Strict environmental and health regulations, as well as the cost-effectiveness of wastewater treatment processes, have made control technology an important priority in the wastewater treatment industry. Control strategies operate on input variables (setpoint values) by choosing the values they should take to influence the evolution of state variables so that output variables (controllable variables) achieve desired values. The object is a pumping unit used in wastewater treatment technology, and its mathematical model is a set of structures reflecting the characteristics of the simulated processes. The main parameters in mathematical models are temperature and vibration level during pump operation, coordinates of …

Enhancing Dynamic Impact Mechanical Properties Of Ultra-High-Performance Concrete With Steel Fiber Reinforcement, Oybek Valijonovich Tuyboyov, Sultonmurod Bekpulatovich Normatov

Technical science and innovation

This study investigates the dynamic impact mechanical properties of Ultra-High-Performance Concrete (UHPC) with high-content and directional reinforced steel fiber. The research explores the influence of directional distributed steel fiber on the dynamic impact properties of UHPC specimens prepared with varying fiber contents. Through experimental analysis using the split-Hopkinson pressure bar (SHPB) method, stress-strain curves, stress peaks, dynamic increase factor (DIF), and ductile energy absorption properties of the specimens at different strain rates were obtained. The results demonstrate that oriented steel fiber significantly enhances the dynamic properties of UHPC, with notable improvements in peak strain, peak stress, and energy absorption capacity. …

Development Of An Effective Container Design That Reliably Provides Isolation Of Water Inflow And Elimination Of Well Flooding, Tolib Olimovich Komilov Suffix, Sherali Hallokovich Umedov, Anvarkhoja Akbarkhodjayevich Rakhimov

Technical science and innovation

Currently, the hydrocarbon extraction industry is one of the most high-tech and rapidly developing sectors globally. The primary priority of this industry is to improve the technical and economic indicators of drilling and well operation. A particularly pressing issue is reducing well waterlogging and effectively isolating water flows, which contributes to optimizing hydrocarbon resource development. The introduction of modern equipment into production processes increases the demand for hydrocarbon resources, further complicating the challenges faced by the industry. This article highlights the relevance of applying innovative technologies to address well complications. Specifically, a new technology for isolating water flows and eliminating …

Development Of The Principles Of Forming A Database For Geoinformation Mapping Of Tourism (As An Example Of Bostanlyk District Of Tashkent Region), Lola Xoji-Akbarovna Gulyamova, Risolat Raximjon Qizi Nizomova

Technical science and innovation

When creating tourist assessment maps for the purpose of tourist mapping, special attention is paid to determining the criteria for the formation of a database. To assess tourism opportunities in terms of natural conditions, ecology and socio-economic factors, data collection, their characteristics and requirements for them were studied. In order to improve the quality of sources of tourist assessment maps, parables of working with the internet and real-time removable data, creating a map based on social network data were considered. Proposals were made to create, manage and maintain a big data base. The ArcGIS program analyzed the possibilities of describing …

Energy Saving Technology For Drying Garlic (Allium Sativum), Jasur Esirgapovich Safarov, Shakhnoza Abduvaxitovna Sultanova, А M. Mirkomilov

Technical science and innovation

Food drying is a widely used preservation method aimed at reducing water content to extend shelf life, decrease weight, and enhance storage efficiency. This process, particularly in garlic, involves rapid initial moisture loss followed by a slower phase due to the increasing difficulty of extracting residual water. Drying methods include natural solar drying and advanced mechanical techniques such as hot air and vacuum drying, each influencing product quality, drying efficiency, and economic feasibility. Dehydrated garlic exhibits specific sensory, physico-chemical, and microbiological characteristics, making it suitable for various applications, including powder production. Advanced drying equipment optimizes air volume, temperature, and material …

Qualitative Analysis Of The Circuits Of Autonomous Inverters With Shut-Off Valves, Shukhrat Badreddinovich Umarov

Technical science and innovation

The article presents the results of a qualitative analysis of circuits of autonomous current and voltage inverters with cut-off valves; the influence of the charge value of the switching capacitor in parallel and series equivalent circuits on the restoration of the switching properties of the thyristors of the inverter power circuit is studied. It is shown that due to the energy periodically accumulated in the inductive elements of the load, the voltage on the switching capacitor in the cut-off state is greater than in a conventional parallel autonomous current inverter. This circumstance ensures an increase in the switching stability of …

Application Of Satellite Interferometry To Tailings Damages To Determine Their Stability, Mukhlisa Khasanovna Rakhimova

Technical science and innovation

In our country and abroad, the construction of special alluvial hydraulic structures - tailings storage facilities - is being carried out on a large scale for storing waste from the mineral enrichment process, the operation of which requires ensuring and observing strict technological control, failure of which leads to serious accidents and even disasters. Tailings dams play a critical role in the mining and metallurgy industry by providing safe storage of production waste. However, their stability and safety are a constant concern. Satellite interferometry (InSAR) is an innovative technology that can effectively monitor deformations and changes in the condition of …

Determination Of Techno-Economic Indicators Of Pumped Storage Power Plants Under The Operational Conditions Of The Tuyamuyun Hydro Complex, Kurbon Salikhdjanovich Dzhuraev, Abdurauf Abduaziz Uulu, Fotima Tulkunovna Shadibekova

Technical science and innovation

The article presents the results of research on the analysis of the state of the electric power system of the Republic of Uzbekistan, taking into account the operating modes of hydraulic and thermal power plants with the study of the sharp-peak nature of the electric load in the winter and summer periods of the year and the problems of covering daily load schedules due to a lack of maneuverable capacities. The use of pumped storage power plants is proposed to cover and smooth daily load schedules across months and seasons. The necessity of utilizing the capacity of pumped storage power …

On Resource Testing Of Straight-Bevel Gears In Drive Mechanisms Of Cotton Machines, Shoraxmat Asqarovich Shaabidov, Umid Mamazokir Ugli Mamasobirov, Azizbek G‘Ulom O‘G‘Li Xusanbayev

Technical science and innovation

This article is dedicated to endurance testing of straight-tooth bevel gear reducers used in various machines, including cotton farming machinery. The choice of the test object is due to the fact that many machines require bevel gear transmissions for spatial arrangement of components. These gears enable the transmission of rotational motion between intersecting shaft axes within compact external dimensions. Additionally, bevel gear transmissions are the most common type of gear mechanisms after cylindrical ones.

For several objective reasons, straight-tooth bevel gears have gained wide use. Unlike cylindrical gears, they are more sensitive to manufacturing and assembly errors as well as …

Method For Calculating Characteristic Frequency Ab (Rechargeable Batteries), Alisher Ganisher Ugli Bozorov

Technical science and innovation

A method for calculating the characteristic frequency is proposed, based on automatic interpolation of the frequency dependence of the reactance and subsequent calculation of the characteristic frequency as one of the roots of the interpolation function. The developed algorithm allows you to calculate the characteristic frequency from only 4 points of the frequency dependence of the reactance. In this case, the error in calculating the resonant frequency parameter does not exceed ~2 Hz.

Obviously, the values of the coefficients of the equation depend on the number of resistance values X and the corresponding frequencies of the test signal. The indicated …

Aperiodic Spectral Slope Tracks The Effects Of Brain State On Saliency Responses In The Human Auditory Cortex, Madaline Mocchi, Eleonora Bartoli, John Magnotti, Jan Willem De Gee, Brian Metzger, Bailey Pascuzzi, Raissa Mathura, Suhruthaa Pulapaka, Wayne Goodman, Sameer Sheth, Matthew J Mcginley, Kelly Bijanki

Faculty, Staff and Students Publications

Alteration of responses to salient stimuli occurs in a wide range of brain disorders and may be rooted in pathophysiological brain state dynamics. Specifically, tonic and phasic modes of activity in the reticular activating system (RAS) influence, and are influenced by, salient stimuli, respectively. The RAS influences the spectral characteristics of activity in the neocortex, shifting the balance between low- and high-frequency fluctuations. Aperiodic '1/f slope' has emerged as a promising composite measure of these brain state dynamics. However, the relationship of 1/f slope to state-dependent processes, such as saliency, is less explored, particularly intracranially in humans. Here, we record …

Front Matter

Texas A&M Law Review

Front Matter.

Post-Pandemic Obstacles Of Clinical Trial Participation In Covid-19 Studies, Tri Nguyen, Lindsay Gietzen

Pacific Journal of Health

The COVID-19 pandemic has created unique challenges for clinical trials, especially in participant recruitment and retention. As the pandemic subsides, post-pandemic trials continue to face barriers to participation. This study investigates obstacles encountered by participants in a Long COVID and COVID Recovered clinical trial conducted between January and August 2024. A Google Form survey was distributed to participants enrolled in the study, which was used to gather data on both demographic information and perceived obstacles to participation. Key obstacles identified included logistical issues such as childcare (33.3%), work flexibility (16.7%), and transportation/lodging (8.3%). In addition, participants indicated a lack of …

Parents Perceptions On The Efficacy Of Common Autism Interventions: A Case Study In Stockton And Lodi California, Jacqueline D. Fox, Lindsay Gietzen

Pacific Journal of Health

A neurological and developmental disability that impacts how people receive information and interact with outside stimuli is known as autism spectrum disorder (ASD). Autism can be characterized by a wide range of symptoms. For children diagnosed with autism, there are numerous therapy options available. The purpose of this study was to find out how effective parents perceived some of the most common autism interventions given to their children were. The interventions included ABA therapy, speech & language therapy, cognitive behavioral therapy, pharmacological, nutrition and educational therapies. Out of all the participants, only one reported a significant improvement in their child …

Administrators’ Perceptions Of Minoritized Students’ Underrepresentation In K-8 Gate, Vernice Verona Sharpe

Walden Dissertations and Doctoral Studies

The purpose of this qualitative study was to understand SWSD administrators’ perceptions of the practices and identification criteria that exacerbated this underrepresentation, guided by a culturally responsive school leadership framework. For this basic qualitative design, eight SWSD administrators with direct knowledge of the GATE programs participated in semistructured interviews. Data analysis involved initial and axial coding, resulting in three key themes: limited cultural awareness among administrators, the importance of incorporating community perspectives, and the need to reevaluate traditional GATE identification practices. Based on these themes, it is recommended to enhance cultural competency training, to engage community members in decision-making, and …

Factors Affecting Waiting Times To Enter Opioid Use Disorder Treatment In The United States With A Particular Focus On Potential Biological Sex Disparity, Stanley Nkemjika, Kenneth Oforeh, Connie Olwit, Olaniyi Olayinka, Terence Tumenta

Department of Psychiatry and Human Behavior Faculty Papers

AIM: Opioid use disorder (OUD) is the problematic use of licit or illicit opioids. Thus far, the literature on biological sex differences in accessing treatment is scarce. Hence, we hypothesize that biological sex has a moderating effect on OUD treatment accessibility. We aim to explore biological sex differences in treatment disparities and its role in wait time to enter OUD treatment.

METHOD: Using the 2018 Treatment Episode Data Set Discharge, the national sample representative of OUD patients in the substance use disorder treatment facilities within the 50 states of the United States was 382,547. Univariate and multivariable logistic analysis of …