Digital Commons Network^™

Personalized And Culturally Tailored Features Of Mobile Apps For Gestational Diabetes Mellitus And Their Impact On Patient Self-Management: Scoping Review, Catherine Jones, Yi Cui, Ruth Jeminiwa, Elina Bajracharya, Katie Chang, Tony Ma

College of Pharmacy Faculty Papers

BACKGROUND: Gestational diabetes mellitus (GDM) is an increasingly common high-risk pregnancy condition requiring intensive daily self-management, placing the burden of care directly on the patient. Understanding personal and cultural differences among patients is critical for delivering optimal support for GDM self-management, particularly in high-risk populations. Although mobile apps for GDM self-management are being used, limited research has been done on the personalized and culturally tailored features of these apps and their impact on patient self-management.

OBJECTIVE: This scoping review aims to explore the extent to which published studies report the integration and effectiveness of personalized and culturally tailored features in …

Onycholysis In An Elderly Woman: Proposal For Treatment With Coix Seed Extract Administration, Yasuhiro Horiuchi

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: The exact etiology of onycholysis, which is characterized by the painless separation of the nail from the nail bed, remains unclear. Currently, there are no established effective treatments for this condition. Coix seed extract (C-S extract), a traditional Chinese medicine, is recognized for its various biological properties.

Case Illustration: This report describes a case of onycholysis affecting the left index finger of a 62-year-old female patient, with initial symptoms appearing three months prior. Despite ongoing internal administration of C-S extract, the patient experienced a recurrence of onycholysis on both the index finger and pinky finger of the left hand …

Lazarin, Burt, Caitlin Omey

Bronx Jewish History Project

Summarized by Avi Frank

Burt Lazarin was born in 1944 and grew up in the Bronx in the Highbridge and Williamsbridge neighborhoods. His family came from Eastern European Jewish backgrounds, with his father’s side immigrating from Lithuania and his mother’s from a region that later became part of Belarus. Lazarin describes growing up in a working to lower-middle-class household, first in a small apartment in Highbridge and later, in 1952, moving to a larger two-family home in Williamsbridge with his parents, brothers, and extended family. Although not religious, Lazarin recalls a strong sense of Jewish identity shaped by family traditions, …

Social Worker Experiences Providing Mental Health Therapy To Iowa Lgbtq+ Youth, Kathy Jochims

Walden Dissertations and Doctoral Studies

High rates of untreated mental health issues and suicidality among LGBTQ+ youth, exacerbated by isolation and rejection in rural areas, demonstrate an urgent necessity for preventive and responsive mental health care. However, access to these essential services remains limited in many rural areas. This study involved using a generic qualitative design to explore the experiences of social workers providing mental health therapy to LGBTQ+ youth in rural Iowa, and presence of cultural humility in social worker practices. The cultural humility theory was chosen as the theoretical framework. Semistructured interviews with 10 Iowa social workers were evaluated using thematic analysis. Study …

Preparing Clinic Staff Nurses To Implement A Newly Hired Rn Preceptorship, Eston Sumner White

Walden Dissertations and Doctoral Studies

Veterans Affairs (VA) and the Department of Defense Healthcare Facilities are among the largest collective of healthcare management systems in the United States. The VA facility in this study has a nurse residency program for new hires and new graduate nurses but lacks a stable cohort of nurse educators to facilitate integration into care for a veteran population and to mentor skills and critical thinking. The purpose of this project was to create a sustained cadre of preceptors for a robust Registered Nurse (RN) program that will prepare recently graduated nurses and new hires for the unique set of situations …

School Principals’ Perception On Their Job Satisfaction, Arti Narayan

Walden Dissertations and Doctoral Studies

The school principal’s roles have become quite complex and strenuous causing an impact on school principals’ job satisfaction. The problem that was addressed through this basic qualitative study was the low job satisfaction of school principals at a school district in California. The framework used for the study was the job demands and resource theory. The purpose of this research study was to examine the perceptions of TK-12 school principals regarding their job satisfaction based on the job demands and resource framework. Using a basic qualitative research design, data were gathered through semistructured interviews with nine school principals out of …

Preoperative Detection Of Extraprostatic Tumor Extension In Patients With Primary Prostate Cancer Utilizing [68ga]Ga-Psma-11 Pet/Mri, Clemens P Spielvogel, Jing Ning, Kilian Kluge, David Haberl, Gabriel Wasinger, Josef Yu, Holger Einspieler, Laszlo Papp, Bernhard Grubmüller, Shahrokh F Shariat, Pascal A T Baltzer, Paola Clauser, Markus Hartenbach, Lukas Kenner, Marcus Hacker, Alexander R Haug, Sazan Rasul

Faculty, Staff and Student Publications

Objectives: Radical prostatectomy (RP) is a common intervention in patients with localized prostate cancer (PCa), with nerve-sparing RP recommended to reduce adverse effects on patient quality of life. Accurate pre-operative detection of extraprostatic extension (EPE) remains challenging, often leading to the application of suboptimal treatment. The aim of this study was to enhance pre-operative EPE detection through multimodal data integration using explainable machine learning (ML).

Methods: Patients with newly diagnosed PCa who underwent [68Ga]Ga-PSMA-11 PET/MRI and subsequent RP were recruited retrospectively from two time ranges for training, cross-validation, and independent validation. The presence of EPE was measured from post-surgical histopathology …

Sulfhydryl-Containing Compounds And Iron Homeostasis: Mechanisms Of Labile Iron Pool Dysregulation And Consequences For Cellular Health, Steven Lowell Mann Christiansen

Theses and Dissertations

While iron's unique coordination chemistry and redox activity have resulted in its broad incorporation into biological systems, dysfunction in key iron-regulating mechanisms can transform these biochemical advantages into factors that contribute to several pathological conditions. This dissertation explores the complex interactions between iron and sulfhydryl-containing compounds (SCCs), with particular focus on glutathione's (GSH) role in stabilizing iron reactivity juxtaposed with homocysteine's (Hcy) ability to disrupt iron homeostasis and promote disease progression. Through rigorous biochemical analysis and experimentation, we demonstrate that Hcy disrupts iron regulation through several mechanisms: (1) Hcy competitively displaces protective iron-binding molecules in the Labile Iron Pool (LIP), …

Optimized Fabrication Of Dendritic Mesoporous Silica Nanoparticles As Efficient Delivery System For Cancer Immunotherapy, Varsha Godakhindi, Mostafa Yazdimamaghani, Sudip Kumar Dam, Farzana Ferdous, Andrew Z. Wang, Mubin Tarannum, Jonathan Serody, Juan L. Vivero-Escoto

Chemical and Biochemical Engineering Faculty Research & Creative Works

In the past decade, cancer immunotherapy has revolutionized the field of oncology. Major immunotherapy approaches such as immune checkpoint inhibitors, cancer vaccines, adoptive cell therapy, cytokines, and immunomodulators have shown great promise in preclinical and clinical settings. Among them, immunomodulatory agents including cancer vaccines are particularly appealing; however, they face limitations, notably the absence of efficient and precise targeted delivery of immune-modulatory agents to specific immune cells and the potential for off-target toxicity. Nanomaterials can play a pivotal role in addressing targeting and other challenges in cancer immunotherapy. Dendritic mesoporous silica nanoparticles (DMSNs) can enhance the efficacy of cancer vaccines …

Direct Methanol Fuel Cells Using Pure Methanol, Ryan Spragg

McKelvey School of Engineering Graduate Student Theses & Dissertations

Fuel cell technology has attained significant appeal as a form of renewable energy in recent years due to its diverse applications, various fuel types, and lower greenhouse gas emissions. Of the various fuel cell types, direct methanol fuel cells (DMFCs) hold a set of distinct advantages for stationary and small portable applications. These advantages include faster refueling compared to battery charging, high gravimetric energy density, and ease of production and use compared to hydrogen. However, the DMFC has numerous technical hurdles that prevent its widespread adoption into the commercial market. Namely, the slow reaction kinetics in the anode and the …

Adjustment To College Following The Covid-19 Pandemic, Neco Xyavier Johnson

Arts & Sciences Graduate Student Theses and Dissertations

ABSTRACT OF THE DISSERTATION Adjustment to College following the COVID-19 Pandemic Objective: The present study examined the relationship between college adjustment and individual differences following the COVID-19 pandemic. It compared the adjustment of students who attended college pre-pandemic (2019) and post-pandemic (2022) and investigated the role of individual difference variables in this adjustment. Method: The study involved 118 pre-pandemic and 250 post-pandemic first-time college students. Both cohorts’ adjustment was assessed at the end of their first semester. The post-pandemic cohort was also evaluated on individual difference measures like loneliness, personality, and emotion regulation. Results: Post-pandemic students exhibited poorer adjustment compared …

Culturally Responsive Social-Emotional Training And Supplemental Resources For Early Childhood Teachers, Danielle Johnson

Masters Projects

Black students are overrepresented in discipline and behavior referrals in the early childhood setting. Given the increasing need for young black children to learn social emotional skills, how can teachers effectively support them with inadequate curriculum? There is significant research that shows the possible reasons why there is an over representation of black students being labeled as a behavior problem in early childhood educational settings. These reasons can create a negative cycle for black students causing much harm to their education and their views of school. Teachers can attempt to resolve this issue by implementing a culturally responsive Social-Emotional Learning …

Tag-Based Security In C: Writing And Specifying Flexible Protection, Sean Noble Anderson

Dissertations and Theses

The C language is ubiquitous and insecure. Tag-based security policies offer a flexible toolkit for runtime protection, including policies that mitigate the effects of undetected programming bugs and those that enforce security properties of the program logic. But tag policies can be difficult to define, and the protection that they offer can be difficult to specify and to prove.

This dissertation builds from an assembly-level specification of stack safety, encompassing the essential control-flow structure of C and other high level languages, to a C source-level policy definition framework called Tagged C. Tagged C includes a variant C semantics parameterized by …

Investigating Student Expectations, Buy-In, And Engagement In Lower Division Undergraduate Chemistry Labs, Elizabeth Blanche Vaughan

Dissertations and Theses

Laboratory courses constitute an integral aspect of chemistry education at the undergraduate level. Despite their prominence, a growing number of researchers have begun to think more critically about the value of laboratory learning experiences. As pedagogical decisions should be based on evidence, it is necessary for chemistry education researchers and practitioners to investigate the claim that teaching laboratories are a valuable part of science education. Therefore, the aim of this dissertation was to address one small section of this gap in the literature by obtaining a more robust understanding of students' expectations, buy-in, and engagement in lower division, undergraduate, chemistry …

Ire1Α Silences Dsrna To Prevent Taxane-Induced Pyroptosis In Triple-Negative Breast Cancer, Longyong Xu, Fanglue Peng, Qin Luo, Yao Ding, Fei Yuan, Liting Zheng, Wei He, Sophie S Zhang, Xin Fu, Jin Liu, Ayse Sena Mutlu, Shuyue Wang, Ralf Bernd Nehring, Xingyu Li, Qianzi Tang, Catherine Li, Xiangdong Lv, Lacey E Dobrolecki, Weijie Zhang, Dong Han, Na Zhao, Eric Jaehnig, Jingyi Wang, Weiche Wu, Davis A Graham, Yumei Li, Rui Chen, Weiyi Peng, Yiwen Chen, Andre Catic, Zhibin Zhang, Bing Zhang, Anthony M Mustoe, Albert C Koong, George Miles, Michael T Lewis, Meng C Wang, Susan M Rosenberg, Bert W O'Malley, Thomas F Westbrook, Han Xu, Xiang H-F Zhang, C Kent Osborne, Jin Billy Li, Matthew J Ellis, Mothaffar F Rimawi, Jeffrey M Rosen, Xi Chen

Faculty, Staff and Students Publications

Chemotherapy is often combined with immune checkpoint inhibitor (ICI) to enhance immunotherapy responses. Despite the approval of chemo-immunotherapy in multiple human cancers, many immunologically cold tumors remain unresponsive. The mechanisms determining the immunogenicity of chemotherapy are elusive. Here, we identify the ER stress sensor IRE1α as a critical checkpoint that restricts the immunostimulatory effects of taxane-chemotherapy and prevents the innate immune recognition of immunologically cold triple-negative breast cancer (TNBC). IRE1α RNase silences taxane-induced dsRNA through RIDD (Regulated IRE1-Dependent Decay) to prevent NLRP3 inflammasome–dependent pyroptosis. Inhibition of IRE1α in Trp53−/− TNBC allows taxane to induce extensive dsRNAs that are sensed …

The Rise, Fall, And Resurgence Of Phage Therapy For Urinary Tract Infection, Jacob J Zulk, Kathryn A Patras, Anthony W Maresso

Faculty, Staff and Students Publications

In the face of rising antimicrobial resistance, bacteriophage therapy, also known as phage therapy, is seeing a resurgence as a potential treatment for bacterial infections including urinary tract infection (UTI). Primarily caused by uropathogenic Escherichia coli, the 400 million UTI cases annually are major global healthcare burdens and a primary cause of antibiotic prescriptions in the outpatient setting. Phage therapy has several potential advantages over antibiotics including the ability to disrupt bacterial biofilms and synergize with antimicrobial treatments with minimal side effects or impacts on the microbiota. Phage therapy for UTI treatment has shown generally favorable results in recent …

Elucidating The Role Of Astrocytes In Norepinephrine Neuromodulation, Katheryn Bry Lefton

Arts & Sciences Graduate Student Theses and Dissertations

Norepinephrine, a wakefulness-associated neuromodulator, profoundly reshapes neural systems, from synaptic circuits to behavior. Through decades of research, a substantial catalogue on the effects of noradrenergic signaling on behavior and networks has been generated. How norepinephrine remodels synaptic circuitry is widely thought to underlie the larger changes in neural networks and behavior, highlighting the need for a more thorough understanding of the circuit effects of norepinephrine neuromodulation. However, the mechanistic details of the norepinephrine on synapses are still unclear. In recent decades, a large body of work has shown that norepinephrine acts not just on neurons, but on glial cells including …

Kenyon Collegian - December 12, 2024

The Kenyon Collegian

No abstract provided.

Climbing The Not-For-Profit Leadership Ladder In Australia: Equity, Diversity, And Inclusion, Cheng Yen Loo, Shajimon Peter, Ian Moore, Michael Grove, Loretta Baldassar

Research outputs 2022 to 2026

This qualitative study examines equity, diversity, and inclusion (EDI) in the leadership roles of not-for-profit organizations (NPOs) where a significant number of social workers engage in professional practice. Two focus groups—one with members of the senior management of NPOs (n = 5) and another with emerging (aspiring and less experienced) leaders of NPOs (n = 6)—were conducted to gather perspectives and opinions on EDI in their organizations’ leadership roles. Four major themes emerged from the findings for promoting EDI, which include a whole of organization commitment, multilevel consideration with recruitment, mentorship, training, and advisory board as an untapped potential. Recommendations …

A Ravelin Outwork Uncovered In The Ottoman Fortifications Of The Old City Of ‘Akko, Joppe Gosker

'Atiqot

A small salvage excavation in ‘Akko exposed the remains of a previously unknown ravelin outwork in the counterscarp of the Ottoman-period fortifications—a previously unknown military feature—which cut through earlier Crusader and Hellenistic layers. Ravelins are known components of city fortifications in Europe from the late sixteenth and seventeenth centuries, continuing in use in the nineteenth century. In ‘Akko, it seems that the construction of the ravelin was not completed.

The Elusive Fortifications Of Yafo (Jaffa), Yoav Arbel

'Atiqot

The port city of Yafo was fortified during much of its four millennia of existence. However, today, even its most recent Ottoman walls are dismantled, and only fragmentary parts of its earlier fortifications have been traced despite decades of research and salvage excavations on the mound and its environs. These limited discoveries cannot provide a comprehensive delineation of any pre-Ottoman defensive lines. Nevertheless, new discoveries, the mapping of scattered sites, comparative observations and consultation with historical sources can shed some light on Yafo’s otherwise obscure fortifications through its many phases, as well as on various related issues. Through these we …

Trebuchets Were Not Siege Guns, So Why Use Them?, Michael S. Fulton

'Atiqot

Counterweight trebuchets were the most powerful ballistic weapons of their day, but their association with later siege guns has led to misunderstandings of their destructive capabilities. This article is an attempt to correct some misguided ideas by providing a short overview of the power and value of mechanical artillery and contextualizing its use in the Levant during the twelfth and thirteenth centuries. After addressing the origin of certain theories that these engines were far more destructive than seems to have been the reality, a brief assessment of their actual power is conducted by looking at the ways sources exaggerate the …

A Methodological Framework For The Archaeology Of Conflicts In The Southern Levant, And The Battle Of Hattin (July 3–4, 1187), Rafael Y. Lewis

'Atiqot

This article presents a research framework for the Archaeology of Conflicts/Battlefield Archaeology. This work was motivated by the methodological challenge posed by the very attempt to study material evidence of events of short duration in the landscape. Such events occurred outside the boundaries of conventional archaeological sites, in the landscape, which is generally subject to more frequent changes. The theoretical model is presented through an examination of the Battle of Hattin, a decisive event that took place on July 3–4, 1187, within the days of the Latin Kingdom of Jerusalem (1099–1291). This theoretical construct can be applied to the study …

The Principia Of The Sixth Legion At Legio/Caparcotani: Ground Penetrating Radar And Excavations In A Legionary Base, Yotam Tepper, Matthew J. Adams, Eileen Ernenwein

'Atiqot

The legionary base at Legio (Legion II Trajana and Legion VI Ferrata) is the first full-scale legionary base of the Principate excavated in the Eastern Empire. The 2015–2019 excavation seasons of the Jezreel Valley Regional Project focused on the headquarters compound, the principia. While many components of the compound are typical of those of permanent legionary bases throughout the Empire, several unique features of the principia at Legio offer new research avenues concerning the function of these buildings within the Roman army administrative system and community life. This paper summarizes the results of the 2015–2019 seasons of excavation and remote …

Were There Jewish Gladiators? A Re-Evaluation Of The Available Archaeological And Textual Evidence, Haggai Olshanetsky

'Atiqot

The participation of Jews in the arena, especially as gladiators, has received relatively little attention. The few articles written on this matter suggest that Jews were both spectators and participants. The present paper relates to all previously suggested indications for the existence of Jewish gladiators and also introduces new ones. Although the possibility that Jewish gladiators were active in the first–fourth centuries CE cannot be ruled out entirely, the evidence remains inconclusive, suggesting that their number was very limited at best. It is also suggested that if Jews had participated in the games, they possibly preferred to fight beasts rather …

Evidence Of The Roman Attack On The Third Wall Of Jerusalem At The End Of The Second Temple Period, Kfir Arbiv

'Atiqot

Remains of a first-century CE wall segment and a tower base uncovered in the Russian Compound, Jerusalem, shed light on the course of the Third Wall in the west of the city and the fierce battle that took place there in the First Jewish Revolt. A concentration of ballista stones and other weapons at the site support the evidence furnished by Josephus in Jewish War, describing the battle at the Third Wall and the siege imposed by Titus on Jerusalem in 70 CE. The archaeological evidence and the historical sources enable a reconstruction of the battle between the Roman army …

The Fortifications Of Tel Burna: A Reappraisal After Twelve Seasons Of Excavations (2010–2022), Aharon Tavger, Chris Mckinny, Deborah Cassuto, Jane Gaastra, Steven Ortiz, Itzhaq Shai

'Atiqot

Tel Burna’s prominent summit, encompassed by a 70 × 70 m casemate fortification, has attracted attention since at least the nineteenth century CE. An analysis of the archaeological data collected during ongoing excavations at the tell indicates that these fortifications were built in the late tenth or early ninth century BCE. The fortification of this Judahite stronghold, located on the border with Philistia, remained in use for the next 200 years. Recently, evidence has come to light of a massive undertaking to reinforce and strengthen the western side of the casemate wall in the late eighth century BCE. The authors …

Weapons, Warrior Burials And Agency In The Intermediate Bronze Age Southern Levant: Some Theoretical Observations, Naama Walzer, Yitzhak Paz

'Atiqot

The Intermediate Bronze Age (c. 2500–2000 BCE) is known for its abundance of formal cemeteries and various other types of burial sites. These comprise a substantial number of internments that contain metal artifacts, identified as weaponry and associated with warfare, and typically defined ‘warrior burials.’ In this paper, we discuss some theoretical issues concerning the identification and role of the so-called weapons, the ideology of warriors and warriorhood, and the mutual agency of objects and society during the Intermediate Bronze Age. Reference is made to examples and research in Europe, where similar patterns have been extensively studied. Through this examination, …

Front Matter & Editorial, The Editorial Board

'Atiqot

Table of contents and Editorial

The Role Of Japan’S Labor And Social Security Attorney (Sharoushi) In Expanding Social Security Coverage; A Benchmark Model For Indonesia’S Perisai, Kader Jkn, And Agenalis", Yoshihiko Ono

Jurnal Administrasi Bisnis Terapan

This study examines the role of Japan's Labor and Social Security Attorney, known as Sharoushi, in expanding social security coverage and ensuring the effective collection of insurance premiums and providing Human Resources Consultation. The Sharoushi system, alongside Japan’s labor insurance office associations, has significantly contributed to the inclusivity and sustainability of Japan's social security framework, especially for small and medium enterprises (SMEs). The study mainly analysis Sharoushi system and compares the Sharoushi system with Indonesia's similar professions, such as Perisai, Kader JKN, and Agenalis, which were inspired by Japanese models and implemented to support informal sector workers. This comparative analysis …