Digital Commons Network^™

Developing Mathematics Teacher Confidence Through Increasing Understanding Of Mathematics, Jennifer Holm

Education Faculty Publications

No abstract provided.

Security Of Mobile Radiological Sources: Overview Of Industry Applied Technologies, Ann M. Archer, Ashleigh Wickham

International Journal of Nuclear Security

Small radiological sources used in industrial settings recurrently require transit between job sites. Securing these sources, while stationary, can be addressed with standard security approaches and equipment. Transport of these sources increases the risk and complexity of managing and maintaining control of these sources. Implementing methodologies to securely monitor and locate sources improves response and resolution of anomalous events during transit. The Mobile Source Transit Security (MSTS) system was developed to improve security and provide situational awareness of these mobile sources throughout their job cycle. The MSTS development effort focused on creating a set of systems that could be successfully …

Creative Reading: Using Poetic Inquiry In Research And Teaching, Clancy Ratliff, Abdullah Al Musayeb, Barja Islam, Mithila Mumtaz, Rosol Otear, Simon Richard, Noah Smith, Nuzhat Tarannum, Allyssa Veney

The Journal of the Assembly for Expanded Perspectives on Learning

Creative Reading: Using Poetic Inquiry in Research and Teaching:

Essay and Poetry.

Organizational Factors Enabling Augmented Analytic And Bi 4.0 Implementation Success, Randy A. Williams, Gazi Murat Duman, Elif Kongar, Nasir J. Sheikh

Engineering and Technology Management Faculty Publications and Presentations

The implementation of modern Business Intelligence (BI) 4.0 and Augmented Analytics solutions is drastically influenced by organizational factors, which are widely recognized as significant drivers of success. Many researchers endeavor to understand critical success factors of BI implementation using various models, most all of which include Organizational components, along with others. Earlier studies have suggested components within the Organizational perspective play a critical role in driving overall BI implementation success. However, the research on organizational factors that focus on the advanced version of BI and augmented analytics is not well established. Addressing this need, the current work focuses on filling …

A Systematic Umbrella Review And Meta-Meta-Analysis Of Ehealth And Mhealth Interventions For Improving Lifestyle Behaviours, Ben Singh, Mavra Ahmed, Amanda E. Staiano, Claire Gough, Jasmine Petersen, Corneel Vandelanotte, Chelsea Kracht, Christopher Huong, Zenong Yin, Maria F. Vasiloglou, Chen Chia Pan, Camille E. Short, Matthew Mclaughlin, Lauren Von Klinggraeff, Christopher D. Pfledderer, Lisa J. Moran, Alyssa M. Button, Carol A. Maher

Population and Public Health Science Faculty Publications

The aim of this meta-meta-analysis was to systematically review randomised controlled trial (RCT) evidence examining the effectiveness of e- and m-Health interventions designed to improve physical activity, sedentary behaviour, healthy eating and sleep. Nine electronic databases were searched for eligible studies published from inception to 1 June 2023. Systematic reviews with meta-analyses of RCTs that evaluate e- and m-Health interventions designed to improve physical activity, sedentary behaviour, sleep and healthy eating in any adult population were included. Forty-seven meta-analyses were included, comprising of 507 RCTs and 206,873 participants. Interventions involved mobile apps, web-based and SMS interventions, with 14 focused on …

Multiomics Analysis To Explore Blood Metabolite Biomarkers In An Alzheimer’S Disease Neuroimaging Initiative Cohort, Takaki Oka, Yuki Matsuzawa, Momoka Tsuneyoshi, Yoshitaka Nakamura, Ken Aoshima, Hiroshi Tsugawa, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski

Clinical Research Faculty Publications

Alzheimer's disease (AD) is a neurodegenerative disease that commonly causes dementia. Identifying biomarkers for the early detection of AD is an emerging need, as brain dysfunction begins two decades before the onset of clinical symptoms. To this end, we reanalyzed untargeted metabolomic mass spectrometry data from 905 patients enrolled in the AD Neuroimaging Initiative (ADNI) cohort using MS-DIAL, with 1,304,633 spectra of 39,108 unique biomolecules. Metabolic profiles of 93 hydrophilic metabolites were determined. Additionally, we integrated targeted lipidomic data (4873 samples from 1524 patients) to explore candidate biomarkers for predicting progressive mild cognitive impairment (pMCI) in patients diagnosed with AD …

Phytoplankton Responses To Changing Irradiance And Carbon Fertilization, Alison Siersma

Graduate Theses and Dissertations (2019 - present)

Phytoplankton play a crucial role in marine ecosystems due to their innate ability to fix carbon. As atmospheric CO2 levels continue to rise from fossil fuel combustion, the resulting increase in dissolved CO2 and the concurrent decrease in ocean pH are likely to impact the phytoplankton community. The response of phytoplankton to elevated CO2 can vary significantly among species and environmental conditions (e.g. light, temperature, nutrient availability). To address these variations, an experiment was conducted using a controlled photobioreactor system, maintaining high and low light, constant temperature, nutrient levels, and two pCO2 concentrations. This study focused on two regionally relevant …

Management Of Possible Serious Bacterial Infections In Young Infants Where Referral Is Not Possible In The Context Of Existing Health System Structure In Mbeya, Tanzania: Experience And Lessons From The End Line Assessment, Esther Ngadaya, Alexander Manu, Mary Mmweteni, Dorica Burengelo, Doreen Philbert, Gibson Kagaruki, Kahabi Isangula, Mbazi Senkoro, Godfather Kimaro, Amos Kahwa

School of Nursing & Midwifery, East Africa

Severe bacterial infections (SBIs) are a leading cause of neonatal deaths in low- and middle-income countries. World Health Organization’s (WHO’s) guideline for outpatient management of danger signs indicating possible serious bacterial infections (PSBI) when referral is not possible was adopted by three pilot district councils in Mbeya Region, in Tanzania (Busekelo, Kyela and Mbarali Districts) in 2018 (the PSBI project). This study documented changes in practice during the PSBI project, and lessons learned. A cross-sectional study was conducted using both qualitative and quantitative data collection methods between July 2021 and January 2022, post-implementation. The study participants comprised stakeholders, health workers, …

Effectiveness Of Clinical Training In Influencing The Outcome Of Visual Inspection With Acetic Acid In Selected Facilities At A County In Kenya, Evah Maina, Abednego Ongeso, Nancy Maingi

School of Nursing & Midwifery, East Africa

Background: Cervical cancer remains a major health concern in developing countries, primarily due to the presence of human papillomavirus (HPV) types 16 and 18. Visual Inspection with Acetic Acid (VIA) is a common and affordable screening method, yet its effectiveness is closely tied to the skills and competency of healthcare providers. This study aimed to assess the impact of clinical training on improving VIA screening outcomes for cervical cancer in a county in Kenya.

Methods: Seven government health facilities equipped with cryotherapy machines were selected, with two healthcare providers sampled from each. A six-day VIA training intervention was conducted, combining …

The Relationship Between Early Dysphagia Screening And Incidence Of Pneumonia Among Acute Stroke Patients, Sabreen Elsedeek Ahmed Assistant Lecturer

Nursing

Background: Post-stroke dysphagia is a common complication of acute stroke, which could increase the risk of mortality and aspiration pneumonia. Aim: This study aimed to assess the relationship between early dysphagia screening and the incidence of pneumonia among acute stroke patients. Research design: A correlational descriptive design was utilized in this study. Setting: The study was conducted at the stroke and neurology intensive care units at As-Salam International Hospital. Subject: a purposive sample of (87) adult patients newly admitted with a diagnosis of acute stroke was included in the study. Tools: Three tools were used in this …

Enhancing Home Energy Efficiency: Web And Cloud Integration For Sustainable Electricity Monitoring, Kyle Aaron Coloma, King Harold A. Recto

Electronics, Computer, and Communications Engineering Faculty Publications

This paper demonstrates how sustainability can be integrated to technology by developing a cloud-based web application that monitors the use of energy in a residential setting. In the development of the minimum viable product (MVP), frontend tools were utilized to ensure that the platform runs on most types of devices. Moreover, backend tools were also used to ascertain efficient handling of data while maintaining security for the users. The project which has guaranteed fundamental functionality and a measure of security has been deployed successfully for early users. For future improvements, it is recommended to prioritize the optimization of user interface …

Zero-G Exercise Equipment, Charisse Biglete, Jake Brajevich, James Monroe, Ethan Siahpush

Mechanical Engineering

In a micro-gravitational environment, the body undergoes less loading than that found on Earth. This leads to muscular atrophy, Osteoporosis, decreases in protein synthesis, and various other undesirable outcomes. To prevent this, astronauts undergo a strict exercise regime to maintain their health. The current exercise equipment available for spacecraft is large, heavy, complicated to use, costly, and unsafe. There is a definite need for the re-engineering of the exercise equipment to be used by astronauts while in microgravity environments to rectify these issues.

The Role Of Graphics And Packaging In Brand Protection, Charlotte Smith

Graphic Communication

This project was focused on how packaging and graphics can be utilized to help minimize the occurrence and risks of counterfeit products in the pharmaceutical industry. During this project, a brand protection plan for a fictional pharmaceutical product was formulated that focused on both developing packaging that is difficult to counterfeit and fostering consumer education. This plan involved covert, semi-covert and overt anti-counterfeiting features which were implemented in the packaging. An educational website was also created for users and distributors in order to enable the end users to identify if that product is genuine. The project objective was to better …

Examining The Relationship Between Internalizing, Externalizing, And Psychotic Psychopathology At Five Levels Of Criminal Risk, Cooper Mitchell Sparks

Theses

Though it is well established that mental illness is not a primary risk factor for criminal justice involvement, the relationship between mental illness and criminal risk with justice-involved persons with mental illness is not well understood (Bonta, et al., 1998; Morgan, et al., 2010; Skeem, et al., 2014). Specifically, psychopathology has not been understood at different levels of criminal risk. Using the Five-Level Risk and Needs System for criminal risk (Hanson, et al., 2017), the current study aimed to identify mean differences between different domains of psychopathology (i.e., internalizing, externalizing, and psychotic psychopathology) across five levels of criminal risk. Data …

A Focus On The Social Validity Of Treating Stereotypy Using Response Interruption And Redirection, Maggie Grace Ratcliff

Theses

Stereotypy refers to a class of operant repetitive motor and vocal responses with no readily apparent goal or purpose (Rapp & Vollmer, 2005; Singer, 2009; Wunderlich et al., 2023). Although most stereotypy is clinically insignificant and does not warrant treatment (i.e., nail biting, hair twirling), some stereotypy persists at a frequency or severity which interferes with skill acquisition, social interactions, and daily living skills. Stereotypy which persists at this level is considered clinically significant and is often the target of treatment (Wunderlich et al., 2023). A variety of evidence-based treatments for the reduction of stereotypy exist, though some neurodiversity advocates …

Integration Of Blockchain Technology In Industrial Applications, Sanjana Sakinala

Theses

This research explores the integration of Hyperledger Fabric., a framework of blockchain in industrial applications, particularly focusing on supply chain management. By addressing the limitations of traditional blockchains - such as high transaction latency, scalability challenges, and privacy concerns - this research demonstrates how Hyperledger fabrics overcomes them. Through simulation, we show significant enhancements in transaction speed, data privacy and scalability, making the Fabric a viable solution for industrial systems.

Using Stimulus Equivalence Procedures To Increase Police Officers' Identification Of Behavioral Functions, Caitlin Sturges

Theses

Mentalistic constructs and theories have been spouted since the dawn of mankind to explain the many behaviors of humans. These philosophies, however, leave many unanswered questions in society’s understanding of why complex behaviors (e.g., the multifaceted behaviors between police officers and citizens) occur. Society has entered an era of policing reform. Moreover, society is in search of answers as to why violent and seemingly complex behaviors are on the rise between law enforcement officials and citizens. The purpose of this study was to teach police officers the four functions of behavior utilizing equivalence-based instruction (EBI). Three active-duty law enforcement officials …

Investigating The Effect Of Metal Site Of The Leaf And Branch Compost Cutinase Through Molecular Dynamics Simulations, Ryan James Molitor

Theses

The petroleum-based polyethylene terephthalate (PET) is a versatile and synthetic polymer that plays a pivotal role in the economy, including packaging, textiles, 3D printers, and even medical-related applications. There is a need for plastic waste management. Biological up-cycling of PET is a promising method for a clean and sustainable future. In 2012, a group of researchers, Tournier et. al., performed experiments and molecular dynamics simulations on the Leaf-branch Compost Cutinase, LCC (PDB Code: 4EB0), which outperformed the PET hydrolysis activity compared to three other PET hydrolyzing enzymes. The LCC and PET depolymerization rate of wildtype LCC was reported to be …

Redistribution With Political Constraints: Legal Rules Compared To Taxes And Transfers, David Weisbach

Penn State Law Review (2003 - Present)

No abstract provided.

The Lesser Of Two Evils: Whether The United States Is Legally Justified In Its Decision To Send Cluster Munitions To Ukraine, Drew Weglarz

Penn State Law Review (2003 - Present)

No abstract provided.

Investigating The Impacts Of Ai Integration On Workplace Well-Being, An Exploratory Case Study, Anezka Viskova-Robertson

Dissertations

In an era characterized by rapid technological advancement, organizations are grappling with the profound changes brought by the integration of artificial intelligence (AI). This study examines the impact of AI integration on workplace well-being, conceptualized as a key indicator of the health of an organization’s socio-technical system. Conducted over a four-month period, this research utilized an exploratory case study approach, collecting data from 35 participants across four distinct organizations. By employing a socio-technical systems perspective and the tripartite model of attitudes, the study investigates the intricate interactions between AI technologies and human factors within organizational contexts. The findings reveal that …

文德 : 中國文論尚德精神的理論基石, Xinglu Zhou

嶺南學報 Lingnan Journal of Chinese Studies

“文德”是中國文論之作家論的基點，貫穿數千年中國文論史，形成了尚德的中國文學傳统。“文人”在社會治理與文明傳承中擔任著重要的任務，因此對“文人”的道德品質有嚴格的要求，而文藝創作天然地崇尚超越規矩、擺脱束縛的精神自由，二者之間構成内在的衛突，於是衍生出“文人無行”的命題。傳统文學批評從正面强調“文德”，德爲主，文爲輔，主次鮮明。面對不同的社會文化現狀，基於不同的思想立場，對“文德”的理解不盡相同。或提倡士先器識而後文藝，或强調士人“不俗”的品格，或主張“性情之正”，以理正情，對情感的抒泄加以疏導和匡正。至明清時期標尚“志士”之詩文，心憂天下，關懷民瘼，個人情懷緊緊聯繫著社會苦難和時代劇變，傳统的“文德”論的内涵因時因地而發展變化，當前中國文論應該有新時代的“文德”論。

Literary Virtue is the basic point of the writer’s theory in Chinese literary theory. It runs through the history of Chinese literary theory for thousands of years and forms a Chinese literary tradition that advocates virtue. Literati played an important role in social governance and civilization inheritance. Therefore, there are particularly strict requirements for the moral quality of literati. Literary and artistic creation naturally advocates spiritual freedom that transcends rules and gets rid of constraints. The two constitute an inner conflict gave rise to the proposition that “literati lack morals”. Traditional literary criticism emphasizes Literary Virtue from the front, …

Correction To: Genotype-Stratified Treatment For Monogenic Insulin Resistance: A Systematic Review (Communications Medicine, (2023), 3, 1, (134), 10.1038/S43856-023-00368-9), Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs, Nestoras Mathioudakis, Chantal Mathieu, Ronald C.W. Ma, Ruth J.F. Loos, Siew S. Lim, Lori M. Laffel

Clinical Research Faculty Publications

Correction to: Communications Medicinehttps://doi.org/10.1038/s43856-023-00368-9, published online 05 October 2023 The file Supplementary Data 3 was missing when this article was published. It has now been added and can be accessed via the Supplementary information section in the online version of the article. Citations to Supplementary Data 3 in the article remain unchanged.

Trajectories Of Offending Over 9 Years After Youths' First Arrest: What Predicts Who Desists And Who Continues To Offend?, Elizabeth Cauffman, Jordan Beardslee, Colleen Sbeglia, Paul J. Frick, Laurence Steinberg

Faculty Publications

Antisocial and illegal behavior generally declines as youth approach adulthood, but there is significant individual variation in the timing of the peak and decline of offending from adolescence to young adulthood. There are two primary research questions in the present study. First, are there subgroups of youth who follow similar patterns of offending over the nine years after their first arrest? Second, what baseline factors predict which youth will follow each pattern of offending? Data were drawn from the Crossroads study, which includes a sample of racially and ethnically diverse boys who were interviewed regularly for 9 years following their …

Estrogen Signaling In The Dorsal Raphe Regulates Binge-Like Drinking In Mice, Valeria C. Torres Irizarry, Bing Feng, Xiaohua Yang, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Hui Ye, Pei Luo, Leslie Carrillo-Sáenz, Penghua Lai, Maya Kota, Devin Dixit, Chunmei Wang, Amy W. Lasek, Yanlin He, Pingwen Xu

Division of Basic Science Faculty Publications

Estrogens promote binge alcohol drinking and contribute to sex differences in alcohol use disorder. However, the mechanisms are largely unknown. This study aims to test if estrogens act on 5-hydroxytryptamine neurons in the dorsal raphe nucleus (5-HTDRN) to promote binge drinking. We found that female mice drank more alcohol than male mice in chronic drinking in the dark (DID) tests. This sex difference was associated with distinct alterations in mRNA expression of estrogen receptor α (ERα) and 5-HT-related genes in the DRN, suggesting a potential role of estrogen/ERs/5-HT signaling. In supporting this view, 5-HTDRN neurons from naïve male mice had …

Exercise Therapy Rescues Skeletal Muscle Dysfunction And Exercise Intolerance In Cardiometabolic Hfpef, Heather Quiriarte, Robert C. Noland, James E. Stampley, Gregory Davis, Zhen Li, Eunhan Cho, Youyoung Kim, Jake Doiron, Guillaume Spielmann, Sujoy Ghosh, Sanjiv J. Shah, Brian A. Irving, David J. Lefer, Timothy D. Allerton

Division of Basic Science Faculty Publications

Exercise intolerance, a hallmark of heart failure with preserved ejection fraction (HFpEF) exacerbated by obesity, involves unclear mechanisms related to skeletal muscle metabolism. In a “2-hit” model of HFpEF, we investigated the ability of exercise therapy (voluntary wheel running) to reverse skeletal muscle dysfunction and exercise intolerance. Using state-of-the-art metabolic cages and a multiomic approach, we demonstrate exercise can rescue dysfunctional skeletal muscle lipid and branched-chain amino acid oxidation and restore exercise capacity in mice with cardiometabolic HFpEF. These results underscore the importance of skeletal muscle metabolism to improve exercise intolerance in HFpEF.

The Impact Of Exercise On Gene Regulation In Association With Complex Trait Genetics, Nikolai G. Vetr, Nicole R. Gay, Joshua N. Adkins, Brent G. Albertson, David Amar, Mary Anne S. Amper, Jose Juan Almagro Armenteros, Euan Ashley, Julian Avila-Pacheco, Dam Bae, Ali Tugrul Balci, Marcas Bamman, Nasim Bararpour, Elisabeth R. Barton, Pierre M. Jean Beltran, Bryan C. Bergman, Daniel H. Bessesen, Sue C. Bodine, Frank W. Booth, Brian Bouverat, Thomas W. Buford, Charles F. Burant, Tiziana Caputo, Steven Carr, Toby L. Chambers, Clarisa Chavez, Maria Chikina, Roxanne Chiu, Michael Cicha, Clary B. Clish, Paul M. Coen, Dan Cooper, Elaine Cornell, Gary Cutter

Clinical Research Faculty Publications

Endurance exercise training is known to reduce risk for a range of complex diseases. However, the molecular basis of this effect has been challenging to study and largely restricted to analyses of either few or easily biopsied tissues. Extensive transcriptome data collected across 15 tissues during exercise training in rats as part of the Molecular Transducers of Physical Activity Consortium has provided a unique opportunity to clarify how exercise can affect tissue-specific gene expression and further suggest how exercise adaptation may impact complex disease-associated genes. To build this map, we integrate this multi-tissue atlas of gene expression changes with gene-disease …

Correction To: Polygenic Effects On The Risk Of Alzheimer’S Disease In The Japanese Population (Alzheimer's Research & Therapy, (2024), 16, 1, (45), 10.1186/S13195-024-01414-X), Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, Ryozo Kuwano, Takeshi Iwatsubo, Akihiro Nakaya, Takeshi Ikeuchi, Michael W. Weiner, Sara S. Mason, Colleen S. Albers, David Knopman, Kris Johnson, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw

Clinical Research Faculty Publications

Following publication of the original article [1], the authors corrected an error in Fig. 2. (Figure presented.) The PRS.noAPOE and PRS.adjLD correlated with CSF Tau/Aβ42 ratios in the MCI. CSF tTau/Aβ42 (A, C) and pTau/Aβ42 (B, D) ratios by decile of PRS are shown in each diagnostic group. The participants were divided into ten groups based on the PRS.noAPOE, ranging from the lowest group (1st decile) to the highest group (10th decile). CN = cognitively normal; MCI = mild cognitive impairment; ADD = Alzheimer’s disease dementia Error: Figs. 2C and D are the same figures as Figs. 2A and B …

Sex Differences In Interacting Genetic And Functional Connectivity Biomarkers In Alzheimer’S Disease, Jordan N. Williamson, Shirley A. James, Sean P. Mullen, Bradley P. Sutton, Tracey Wszalek, Beni Mulyana, Peter Mukli, Andriy Yabluchanskiy, Balebail Ashok Raj, Kristin Fargher, Amanda Smith, Lisa Raudin, Gloria Chaing, Norman Relkin, Karen Elizabeth Smith, Hyungsub Shim, Laura L.Boles Ponto, Susan K. Schultz, Antero Sarrael, Raymundo Hernando, Nunzio Pomara, Dick Drost, Andrew Kertesz, John Rogers, Irina Rachinsky, Stephen Pasternak, Elizabether Finger, David Bachman, Kenneth Spicer, Jacobo Mintzer, Bruce L. Miller, Howard J. Rosen, Stephen Correia, Paul Malloy

Clinical Research Faculty Publications

As of 2023, it is estimated that 6.7 million individuals in the United States live with Alzheimer’s disease (AD). Prior research indicates that AD disproportionality affects females; females have a greater incidence rate, perform worse on a variety of neuropsychological tasks, and have greater total brain atrophy. Recent research shows that hippocampal functional connectivity differs by sex and may be related to the observed sex differences in AD, and apolipoprotein E (ApoE) ε4 carriers have reduced hippocampal functional connectivity. The purpose of this study was to determine if the ApoE genotype plays a role in the observed sex differences in …

Cerebrovascular Markers Of Wmh And Infarcts In Adni: A Historical Perspective And Future Directions, Pauline Maillard, Evan Fletcher, Owen Carmichael, Christopher Schwarz, Stephan Seiler, Charles Decarli

Clinical Research Faculty Publications

White matter hyperintensities (WMH) and infarcts found on magnetic resonance imaging (MR infarcts) are common biomarkers of cerebrovascular disease. In this review, we summarize the methods, publications, and conclusions stemming from the Alzheimer's Disease Neuroimaging Initiative (ADNI) related to these measures. We combine analysis of WMH and MR infarct data from across the three main ADNI cohorts with a review of existing literature discussing new methodologies and scientific findings derived from these data. Although ADNI inclusion criteria were designed to minimize vascular risk factors and disease, data across all the ADNI cohorts found consistent trends of increasing WMH volumes associated …