Digital Commons Network^™

The Constitutional Case Against State-Controlled Fact-Checking: A Case Comment On Kunal Kamra V. Union Of India, Abhinav Ravi, Aravind Sundar

National Law School of India Review

The Bombay High Court in Kunal Kamra v Union of India struck down the Information Technology (Intermediary Guidelines and Digital Media Ethics Code) Amendment Rules, 2023, which had established a centralised fact-checking unit to issue takedown orders against social media posts that were identified as “fake or false or misleading”. The Rules threatened the safe harbour protection of social media intermediaries for failing to adhere to such takedown orders. The Court held that the establishment of the fact-check unit violates the rights of free speech, profession and equality under the Indian Constitution. This article explores the free speech implications of …

Enrollment Of Females In Randomized Trials For Glucagon-Like Peptide 1 Receptor Agonists: A Systematic Review, Frederick Berro Rivera, Mc John Caro Ybañez, John Vincent Magalong, Mario Prado, Eloise Arias Aguirre, Ana Patricia Ting Cañares, Janos Marc Rubia, Allyn Ralph Hiyas, Polyn Luz S. Pine, Kyla Lara-Breitinger, Francisco Lopez-Jimenez, Martha Gulati

Ateneo School of Medicine and Public Health Publications

Background

Randomized controlled trials (RCTs) of glucagon-like peptide 1 receptor agonists (GLP-1RAs) form the basis for therapeutic recommendations for both males and females. Historically, females have been significantly underrepresented in RCTs.

Objectives

The authors sought to determine the trends of representation of females in GLP-1RA RCTs from 2007 to 2024.

Methods

We reviewed eligible studies and extracted important variables. The proportion of females among the total participants was obtained per study. This was compared over time (year) of publication and over mean age of participants. This proportion was also compared between specific types of GLP-1RA received, diabetes status, indication of …

Genome-Wide Expression Profiling And Phenotypic Analysis Of Downstream Targets Identify The Fox Transcription Factor Jumeau As A Master Regulator Of Cardiac Progenitor Cell Division, M. Rezaul Hasan

Bakerman Student Research Awards

Forkhead box (Fox) transcription factors (TFs) mediate multiple conserved cardiogenic processes in both mammals and Drosophila. Our prior work identified the roles of two Drosophila Fox genes, jumeau (jumu) and Checkpoint suppressor 1-like (CHES-1-like), in cardiac progenitor cell specification and division, and in the proper positioning of cardiac cell subtypes. Fox TF binding sites are also significantly enriched in the enhancers of genes expressed in the heart, suggesting that these genes may play a core regulatory role in one or more of these cardiogenic processes. We identified downstream targets of Jumu by comparing transcriptional expression profiles of flow cytometry-sorted mesodermal …

Kinetics Of Naturally Induced Binding And Neutralising Anti-Sars-Cov-2 Antibody Levels And Potencies Among Sars-Cov-2 Infected Kenyans With Diverse Grades Of Covid-19 Severity: An Observational Study, John Kimotho, Yiakon Sein, Shahin Sayed, Reena Shah, Mansoor Saleh, Ann Karanu, Viviane Oluoch, Jasmit Shah, Julius Mutiso, Zaitun Nneka, Alfred Mburu, Peter Betti, Francis M. Ndungu

Pathology, East Africa

Background: Given the low levels of coronavirus disease 2019 (COVID-19) vaccine coverage in sub-Saharan Africa (sSA), despite high levels of natural severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) exposures, strategies for extending the breadth and longevity of naturally acquired immunity are warranted. Designing such strategies will require a good understanding of naturally acquired immunity.

Methods: We measured whole-spike immunoglobulin G (IgG) and spike-receptor binding domain (RBD) total immunoglobulins (Igs) on 585 plasma samples collected longitudinally over five successive time points within six months of COVID-19 diagnosis in 309 COVID-19 patients. We measured antibody-neutralising potency against the wild-type (Wuhan) SARS-CoV-2 …

Perceptual Hash Based Content Matching, Nicholas Daniel Chenevey

Master's Theses

The proliferation of video content and AI generated imagery has introduced a number of new challenges in content identification and verification. The ability to trace content back to its source has become a critical problem as video content increases both naturally and synthetically through AI generation. This thesis provides the design, analysis, and experimental verification for a perceptual hash based framework aimed at addressing these challenges. Perceptual hashing is a method for encoding the visual content of images into compact and easily comparable binary strings. This process is used as the foundation for content matching in videos and source verification …

The Integration And Validation Of A Class 3b Laser For Stereo Particle Imaging Velocimetry, Jensen Lam

Master's Theses

Particle Imaging Velocimetry (PIV) is a laser flow diagnostic measurement technique used to measure spatial and temporal velocity fields. In an effort to promote experimental aerodynamic research, specifically an entry point for students to learn Particle Imaging Velocimetry, an in-house Class 3B laser PIV system was developed and its experimental results were verified with a Class 4 laser. Both systems were integrated on the Cal Poly Water Tunnel Laboratory. The work emphasizes the application of lasers controlled by a micro-controller to perform microsecond-based pulses and integrating a newly-developed device with an old system consisting of software, cameras, and synchronizers. The …

Generating A Novel Legislator Organization Score, Brandon Lin

Master's Theses

Ever since the 2010 Citizens United v. FEC, corporations and organizations have been able to contribute expenditures and resources into political legislators and campaigns. It has become apparent over the years that organizations can excise significant influence in direct ways to influence campaigns across the United States. During this period, Digital Democracy has collected large amounts of data pertaining to legislative bill information, voting patterns, and donations on behalf of the California public to raise awareness. Digital Democracy has also released its own scoring system that compares the amount of aligning votes between a legislator and an organization. However, this …

Feedback For Learning From Text: What Kind And Where In The Text Is Most Effective?, Virginia Clinton-Lisell

Education, Health & Behavior Studies Faculty Publications

Etextbooks have the affordance of providing immediate feedback for review questions on the content. However, it needs to be clarified what type and placement of feedback is most effective. College and high school students (N = 390) were randomly assigned to receive either correct-answer-only feedback or elaborative feedback either in the middle-and-end of the textbook excerpt or the end only. Elaborative feedback at the end of the text had more accurate posttest scores and more efficient learning (based on time reading per correct answer) than did other conditions. Metacomprehension accuracy, based on the difference between predicted performance and actual …

Interactional Ordering: Reconstructing Lon Fuller's Theory Of Private Law, Shyamkrishna Balganesh

Faculty Scholarship

While Lon Fuller is best remembered for his contributions to the fields of general jurisprudence and contract law, his work in each has long been seen as unrelated to the other. This Article shows that in a significantly underappreciated body of work, Fuller did connect the two and, in the process, developed the outlines of a robust theory of private law, best characterized as “interactional ordering.” Driven by Fuller’s efforts to develop a jurisprudence of form that was derived from conventionalism and natural law thinking, interactional ordering sees all normativity as originating in horizontal interactions between individuals in society, seeking …

Tumor Expression Of Cd83 Reduces Glioma Progression And Is Associated With Reduced Immunosuppression, Malcolm F Mcdonald, Rachel Naomi Curry, Isabella O'Reilly, Brittney Lozzi, Alexis Cervantes, Zhung-Fu Lee, Anna Rosenbaum, Peihao He, Carrie Mohila, Arif O Harmanci, Akdes Serin Harmanci, Benjamin Deneen, Ganesh Rao

Faculty, Staff and Student Publications

Immunosuppression in malignant glioma remains a barrier to therapeutic development. CD83 overexpression in human and mouse glioma increases survival. CD83+ tumor cells promote signatures related to cytotoxic T cells, enhanced activation of CD8+ T cells, and increased proinflammatory cytokines. These findings suggest that tumor-expressed CD83 could mediate tumor-immune communications.

Efficacy And Feasibility Of Intradialytic Plantar Electrical Stimulation In Patients With Diabetes: A Randomized Double-Blind Controlled Trial, Myeounggon Lee, Abdullah Hamad, Mehrnaz Azarian, Jaewon Beom, Abderrahman Ouattas, Mohammad Dehghan Rouzi, Naima Rodriguez, Nhi Quach, Rania Ibrahim, Mincy Mathew, Talal Talal, Fadwa Al-Ali, Bijan Najafi

Center on Aging Staff Publications

Objective: This study investigates the efficacy and feasibility of electrical stimulation (E-Stim) on sensory fibers of the plantar region during hemodialysis sessions, aiming to improve mobility in patients with diabetes by providing a connection between E-Stim and enhanced mobility with minimal patient effort required.

Research design and methods: Participants aged ≥18 years with diabetes undergoing hemodialysis and able to walk at least 10 m with or without aid were recruited and divided into an intervention group receiving 1-h intradialytic E-Stim three times a week and a control group using an identical nonfunctional device for 12 weeks. Gait, physical activity, patient-reported …

Spine Mobilization Vs Manipulation: Effects On Neck Pain, Alfredo Loreto

Loma Linda University Electronic Theses, Dissertations & Projects

Several studies have found an association between cervical spinal mobilization (CSMob) and cervical spinal manipulation (CSM) on pain perception, disability, and satisfaction. However, choosing the proper technique continues to be a challenge for many practitioners. The purpose of this study was to clarify the discrepant evidence regarding the efficacy of a CSMob versus a CSM intervention as compared to a control group – hands-off, and patient education (PE) in isolation. 36 subjects with acute and non-specific mechanical neck pain were randomly assigned to one of 3 groups (CSMob, CSM, or control). Outcome measures using the Neck Disability Index (NDI), Numeric …

Accelerating Heritability, Genetic Correlation, And Genome-Wide Association Imaging Genetic Analyses In Complex Pedigrees, Brian Donohue, Si Gao, Thomas E. Nichols, Bhim M. Adhikari, Yizhou Ma, Neda Jahanshad, Francis J. Mcmahon, Elizabeth M. Humphries, William Burroughs, John Blangero

School of Medicine Publications

National and international biobanking efforts led to the collection of large and inclusive imaging genetics datasets that enable examination of the contribution of genetic and environmental factors to human brains in illness and health. High-resolution neuroimaging (~104–6 voxels) and genetic (106–8 single nucleotide polymorphic [SNP] variants) data are available in statistically powerful (N = 103–5) epidemiological and disorder-focused samples. Performing imaging genetics analyses at full resolution afforded in these datasets is a formidable computational task even under the assumption of unrelatedness among the subjects. The computational complexity rises as ~N2–3 (where N is the sample size), when …

Validation Of Human Telomere Length Multi-Ancestry Meta-Analysis Association Signals Identifies Pop5 And Kbtbd6 As Human Telomere Length Regulation Genes, Rebecca Keener, Surya B. Chhetri, Carla J. Connelly, Margaret A. Taub, Matthew P. Conomos, Joshua Weinstock, Bohan Ni, Benjamin Strober, Stella Aslibekyan, John Blangero

School of Medicine Publications

Genome-wide association studies (GWAS) have become well-powered to detect loci associated with telomere length. However, no prior work has validated genes nominated by GWAS to examine their role in telomere length regulation. We conducted a multi-ancestry meta-analysis of 211,369 individuals and identified five novel association signals. Enrichment analyses of chromatin state and cell-type heritability suggested that blood/immune cells are the most relevant cell type to examine telomere length association signals. We validated specific GWAS associations by overexpressing KBTBD6 or POP5 and demonstrated that both lengthened telomeres. CRISPR/Cas9 deletion of the predicted causal regions in K562 blood cells reduced expression of …

Developing A Bilingual Health Education Program To Identify And Address Healthcare Misinformation In A Border Community, Sara Mansour, Nathan Holland, Sergio Saucedo, Amadeus Ramirez, Mariela Lane, Joshua Salisbury, Komal Marwaha, Lorena Fernandez, Jesse Allen, Ricardo Belmares

School of Medicine Publications

El Paso Health Education and Awareness Team (EP-HEAT®) is a bilingual program focused on increasing health awareness and dispelling health-related misinformation in the U.S.-Mexico border region. EP-HEAT® consists of students, faculty, staff, and Promotoras. The primary objective of EP-HEAT® is to empower the community with healthcare resources in a culturally acceptable way. EP-HEAT® established the bilingual “In the Hot Seat with EP-HEAT®: Dispelling Myths in Healthcare” series commonly referred to as Myth Busters events. Community members were surveyed following the events. Our results showed the majority of EP-HEAT® event attendees identified as Hispanic and were older than 46 years …

Downtown Hattiesburg: In History And Memory, Joseph Reosti

Honors Theses

This paper explores how public memory of Downtown Hattiesburg has been shaped by race, class, and historical change, drawing primarily on oral history interviews conducted by the author. Once the heart of the city, Downtown Hattiesburg experienced significant decline from the 1970s onward due to suburbanization, white flight, and demographic shifts. In response, the 1970s saw the emergence of a historic preservation movement focused on revitalizing memories of the city's early 20th-century prosperity (1910-1929), often idealized as a period of economic success even despite racial segregation. Many interviewees identified this era as the city’s "golden age," despite its deeply inequitable …

Understanding Mental Health Awareness And Knowledge Of Flight Instructors, Eric Michael Buteau

Theses and Dissertations

Mental health has become an increasing concern in the aviation industry, with pilots often withholding health information for fear of losing their medical certification. Certified Flight Instructors (CFIs), who interact closely with students, are in a unique position to recognize and address mental health crises but lack sufficient training in this area. This study examines CFIs' awareness, knowledge, comfort, and willingness to engage with mental health issues in aviation. A survey was distributed to CFIs at a large aviation university. Survey results revealed no significant correlation between years of experience and knowledge or comfort with mental health topics. However, a …

Parp1 Modulates Gata3-Mediated Gene Regulation In Breast Cancer, Mikhala Cooper

Theses and Dissertations

In eukaryotic cells, chromatin acts as a physical barrier for many transcription factors, preventing them from efficiently binding to their recognition sequences within the nucleosome. Pioneer factors are a class of transcription factors that bind to nucleosomes and activate silent chromatin. Pioneer factors are frequently involved in various immune cell pathways, tissue development, and homeostasis, thereby underscoring their important roles in development and disease. Previous research found that pioneer factors have at least three fundamental properties: 1) they can interact with their cognate recognition sequences before transcription activation, 2) they can increase local chromatin accessibility, and 3) they have integral …

The Nursing Human Capital Value Model, Olga Yakusheva, Kathryn A. Lee, Marianne Weiss

College of Nursing Faculty Research and Publications

Nursing's economic value is presently framed within the dominant “outcomes-over-cost” value framework. Within this context, organizations employing nurses often use nursing budget reductions as a cost-minimization strategy, with the intent of retaining high quality outcomes. However, persistent issues such as nurse understaffing, burnout, and turnover threaten healthcare systems' capacity to deliver the quality, equitable, affordable patient care that the public requires. In this paper, we propose a new conceptual model and definition of nursing's economic value. The model development is guided by the convergence of three classic economic frameworks: human capital theory, production theory, and value theory. Grounded in these …

Metacognition Across The Curriculum, Amber Young-Brice

College of Nursing Faculty Research and Publications

For nursing students to succeed, they must reflect on their learning, think critically, and develop skills to adequately retrieve pertinent information relevant to patient care (Waryold et al., 2021). We often hear, “Just tell me what I need to know,” and witness students struggling to think deeply, reflect on if they are making the right decisions for the right reasons, and gain self-awareness of what they know and what they do not know. What can we do about this?

Student Use Of Electronic Health Records To Inform Decision-Making: A Pilot Study, Sarah Marie Calonder, Aimee A. Woda

College of Nursing Faculty Research and Publications

Background

As health care continues to evolve, the electronic medical record (EHR) has emerged as an important decision-making tool. To ensure that nursing students work toward competency with the EHR, this study sought to gather information regarding how students use the EHR.

Method

Students in a direct-entry, prelicensure program were observed using the EHR during a simulation-based experience (SBE). Focus groups gathered qualitative student perceptions of EHR use.

Results

Minimal use of the EHR during SBE was identified. Students reported using the EHR for information gathering, validating findings, and nursing tasks.

Conclusion

This study highlights the need for more robust …

Reflecting On Diagnosis: The Metacognitive Diagnostic Reasoning Model©, Sarah L. Beebe, Angela M. Mcnelis, Majeda El-Banna, Kristina Thomas Dreifuerst

College of Nursing Faculty Research and Publications

Background:

Diagnostic reasoning is a complex cognitive process that requires intuitive, heuristic processing from knowledge and experience, as well as deliberate and reflective thinking. Evidence on interventions to improve diagnostic reasoning is inconsistent, in part because different terms and models are used to guide research.

Purpose:

To present a model of the factors of diagnostic reasoning in Advanced Practice Registered Nurses (APRNs), based on a review of the literature supporting the Metacognitive Diagnostic Reasoning (MDR) Model^©.

Methodology:

A review of the literature through systematic database search, historical articles, texts, and documents was conducted from inception through August 2023 …

Law And Equity On Appeal, Aaron-Andrew P. Bruhl

Faculty Publications

Most lawyers know that the Federal Rules of Civil Procedure merged the divergent trial procedures of the common law and of equity, but fewer are familiar with the development of federal appellate procedure. Here too there is a story of the merger of two distinct systems. At common law, a reviewing court examined the record for errors of law after the final trial judgment. In the equity tradition, an appeal was a rehearing of the law and the facts that aimed at achieving justice and did not need to await a final judgment. Unlike the story of federal trial procedure, …

Experiences In Providing A Community Educational Resource For The All Of Us Researcher Workbench, Deborah I Ritter, Jinyoung Byun, Jun Wang, Stephen Richards, Pamela N Luna, Laterrica Williams, Julie R Coleman, Jasmine N Baker, Shamika Ketkar, Ashley M Butler, Latanya Hammonds-Odie, Elizabeth G Atkinson, Kim C Worley, Debra D Murray, Brendan Lee, Steven E Scherer

Faculty, Staff and Students Publications

OBJECTIVE: Educational offerings to fill the bioinformatics knowledge gap are a key component to enhancing access and use of health data from the All of Us Research Program. We developed a Train the Trainer-based, innovative training series including project-based learning, modular on-demand demonstrations, and unstructured tutorial time as a model for educational engagement in the All of Us community.

MATERIALS AND METHODS: We highlight our training modules and content, with training survey data informing cycles of development in the creation of a 6-module training series with modular demonstrations.

RESULTS: We have conducted 2 public iterations of the Train the Trainer …

Association Of Common And Rare Variants With Alzheimer’S Disease In More Than 13,000 Diverse Individuals With Whole-Genome Sequencing From The Alzheimer’S Disease Sequencing Project, Wan-Ping Lee, Seung Hoan Choi, Margaret G Shea, Po-Liang Cheng, Beth A Dombroski, Achilleas N Pitsillides, Nancy L Heard-Costa, Hui Wang, Katia Bulekova, Amanda B Kuzma, Yuk Yee Leung, John J Farrell, Honghuang Lin, Brian W Kunkle, Adam Naj, Elizabeth E Blue, Frederick Nusetor, Dongyu Wang, Eric Boerwinkle, William S Bush, Xiaoling Zhang, Philip L De Jager, Josée Dupuis, Lindsay A Farrer, Myriam Fornage, Eden Martin, Margaret Pericak-Vance, Sudha Seshadri, Ellen M Wijsman, Li-San Wang, Alzheimer's Disease Sequencing Project, Gerard D Schellenberg, Anita L Destefano, Jonathan L Haines, Gina M Peloso

Center for Medical Ethics and Health Policy Staff Publications

Introduction: Alzheimer's disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous.

Methods: We investigated the association of AD with both common variants and aggregates of rare coding and non-coding variants in 13,371 individuals of diverse ancestry with whole genome sequencing (WGS) data.

Results: Pooled-population analyses of all individuals identified genetic variants at apolipoprotein E (APOE) and BIN1 associated with AD (p < 5 × 10-8). Subgroup-specific analyses identified a haplotype on chromosome 14 including PSEN1 associated with AD in Hispanics, further supported by aggregate testing of rare coding and non-coding variants in the region. Common variants in LINC00320 were observed associated with AD in Black individuals (p = 1.9 × 10-9). Finally, we observed rare non-coding variants in the promoter of TOMM40 distinct of APOE in pooled-population analyses (p = 7.2 × 10-8).

Discussion: We observed that complementary pooled-population and subgroup-specific analyses offered unique insights into the genetic architecture of AD.

Highlights: We determine the association of genetic variants with Alzheimer's disease (AD) using …

An Analysis Of Policies, Practices, And Barriers To Create A Multi-Dimensional Approach To Renewable Energy Transition For Us Communities, Hanan Wehbi

Graduate Theses and Dissertations

The transition from fossil fuel-derived energy resources to clean, renewable, affordable, and reliable energy necessitates a comprehensive approach. This approach must incorporate an interdisciplinary contribution to ensure the sustainability, efficiency, and resilience of the energy system. In the United States, many communities and local governments are developing ambitious plans, regulations, and targets to support the renewable energy transition and enhance energy efficiency. This research builds on the principles of sustainable development planning and transition theory to develop a framework that assists communities in planning their renewable energy (RE) transition and integrate these plans in their long- and short-term development approaches. …

Perceived Barriers And Facilitators Of Behavioral-Health Modality Change Adoption During The Covid-19 Pandemic: A Systematic Review, Nicholas Sims-Rhodes, Hannah E. Cornwell, Emily Barena, Vandy C. Dubre, Kimberly S. Elliott, Eman H. Nabulsi, Nelly Yuen, Sarah Sass, Anastasia Miller, Yordanos M. Tiruneh, Karan P. Singh

Presentations and Publications

Introduction: During the Coronavirus Disease 2019 pandemic, there was a surge in demand for mental health services worldwide, presenting challenges for healthcare institutions as they navigated changes in policy and safety regulations. In the United States, this resulted in many behavioral health modality changes to remain in compliance with the Center for Disease Control guidelines. A growing body of literature has documented these, yet few explored barriers and facilitators affecting the adoption of these modality delivery changes. The researchers conducted a systematic review using the PRISMA method, focusing on service delivery changes across healthcare systems in the United States from …

Spoiling The “Fruits Of Their Own Labor”: Mole’ V. City Of Durham, Drew Alexander

North Carolina Law Review

No abstract provided.

Aged 539- Internship In Agriculture Education - Waterford High School, Jennifer Pierce

Agricultural Education: Graduate Internship Reports

This report explores the development and implementation of an agricultural education program plan aimed at enhancing student engagement, community involvement, and career readiness. Drawing from established models of program planning and needs assessment, the report focuses on the integration of instructional strategies, supervised agricultural experiences (SAEs) and FFA involvement to foster comprehensive student development. The plan outlines key goals such as increasing student enrollment, improving curriculum alignment with industry standards, and expanding partnerships with local agricultural stakeholders. Strategies include curriculum enhancement, teacher professional development, and the use of data-driven decision-making. The report also emphasizes the importance of evaluation and continuous …

Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance In Healthy Men, Chad M. Kerksick

Faculty Scholarship

Background: Choline is an essential nutrient required for proper cell functioning. Due to its status as a precursor to acetylcholine, an important neurotransmitter connected to cognition and neuromuscular function, maintaining or enhancing choline levels is of interest. Supplementation with alpha-glycerylphosphorycholine (A-GPC) can maintain choline levels, but its ability to offer support towards cognition remains an area of ongoing research. Methods: Using a randomized, double-blind, placebo-controlled, crossover approach, 20 resistance-trained males (31.3 ± 11.0 years, 178.6 ± 7.3 cm, 84.6 ± 11.4 kg, 15.4 ± 5.6% body fat) consumed either a placebo (PL), 630 mg A-GPC (HD), or 315 mg (LD) …