Digital Commons Network^™

Regular Nonsteroidal Anti-Inflammatory Drug Use Increases Stress Fracture Risk In The General Population: A Retrospective Case-Control Study, Alexandra Ciuciu, Chris Mulholland, Michael A. Bozzi, Chris C. Frymoyer, Leonardo Cavinatto, David Yaron, Marc I. Harwood, Jeremy D. Close, Christopher J. Mehallo, Ryan E. Tomlinson

Department of Orthopaedic Surgery Faculty Papers

Previous studies have shown that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with increased stress fracture risk. This phenomenon has been studied predominantly in high-activity individuals, so data regarding the general population are limited despite the substantial economic and resource burden of stress fracture injuries within the general US population. Furthermore, our preclinical studies demonstrate that regular use of NSAIDs also diminishes the intrinsic ability of bone to resist fracture. To determine the association of regular NSAID use with stress fractures in the general population, we surveyed subjects presenting with either stress fracture or uncomplicated ankle sprain to …

Pain After Licorice Or Sugar-Water Gargling In Patients Recovering From Oropharyngeal Surgery-A Randomized, Double-Blind Trial, Marita Windpassinger, Michal Prusak, Jana Gemeiner, Olga Plattner, Stefan Janik, Gerold Besser, Wolfgang Gstoettner, Pu Xuan, Daniel I Sessler, Kurt Ruetzler

Faculty, Staff and Student Publications

Background: Glycyrrhiza glabrata (licorice) is used in traditional medicine and herbal remedies and reduces sore throats consequent to intubation, but whether it is protective for more intense pain after oropharyngeal surgery remains unclear. We thus tested the joint hypothesis that gargling with licorice, which has anti-inflammatory and antioxidant properties, reduces postoperative pain and morphine consumption.

Methods: We enrolled patients having elective oropharyngeal surgery. Participants were randomly allocated to gargle with either 1 g licorice or a sugar placebo before and for up to three days after surgery. A numerical rating scale (NRS) for pain along with morphine consumption was evaluated …

Interleukin-1 Receptor-Associated Kinase 1 In Cancer Metastasis And Therapeutic Resistance: Mechanistic Insights And Translational Advances., Mariana K Najjar, Munazza S Khan, Chuling Zhuang, Ankush Chandra, Hui-Wen Lo

Faculty, Staff and Student Publications

Interleukin-1 Receptor Associated Kinase 1 (IRAK1) is a serine/threonine kinase that plays a critical role as a signaling transducer of the activated Toll-like receptor (TLR)/Interleukin-1 receptor (IL-1R) signaling pathway in both immune cells and cancer cells. Upon hyperphosphorylation by IRAK4, IRAK1 forms a complex with TRAF6, which results in the eventual activation of the NF-κB and MAPK pathways. IRAK1 can translocate to the nucleus where it phosphorylates STAT3 transcription factor, leading to enhanced IL-10 gene expression. In immune cells, activated IRAK1 coordinates innate immunity against pathogens and mediates inflammatory responses. In cancer cells, IRAK1 is frequently activated, and the activation …

A Proteomics Approach To Study Mouse Long Bones: Examining Baseline Differences And Mechanical Loading-Induced Bone Formation In Young-Adult And Old Mice, Christopher J Chermside-Scabbo, John T Shuster, Petra Erdmann-Gilmore, Eric Tycksen, Qiang Zhang, R Reid Townsend, Matthew J Silva

2020-Current year OA Pubs

With aging, bone mass declines and the anabolic effects of skeletal loading diminish. While much research has focused on gene transcription, how bone ages and loses its mechanoresponsiveness at the protein level remains unclear. We developed a novel proteomics approach and performed a paired mass spectrometry and RNA-seq analysis on tibias from young-adult (5-month) and old (22-month) mice. We report the first correlation estimate between the bone proteome and transcriptome (Spearman

Vol. 33, No. 12 / Vol. 34, No. 1 - Whole No. 178, Bernadette Bosky

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 33, No. 9-11 - Whole No. 177, Bernadette Bosky

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 33, No. 4-7 - Whole No. 175, Bernadette Bosky

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Crypto & The Climate: Will Local & National Environmental Regulation Save Or Stifle The Cryptocurrency Boom?

Fordham Environmental Law Review

As cryptocurrencies continue to gain traction among mainstream investors and consumers, regulators and lobbyists are increasingly taking note of the potential environmental impacts of the industry. At its core, the process of mining new currency for virtual wallets is energy intensive, which can place strains on electrical grids and accelerate the impacts of climate change. However, these effects are felt very differently depending on what source of electricity the mining operation utilizes and the methodology behind the specific currency. These variable factors are on the minds of legislators and regulators as public pressure to better understand and regulate the industry …

A Shifting Focus: How Algal Turf Scrubbers (Ats) In Natural Waterways Can Prevent Toxic Blooms And Could Save The Algae Energy Industry

Fordham Environmental Law Review

Biofuels have generated global interest among oil companies and governments. In particular, algal biofuels are slated to be more promising than traditional biofuel feedstocks, like corn and sugarcane, which are simultaneously cultivated as food products. However, the drawbacks of harvesting algae on a large industrial scale has led to intense criticism. Most critics focus on issues of sustainability, scalability of production, and the legal and ethical concerns of genetically modified crops. New research in cyanobacteria, however, illustrates algae’s potential to produce clean electricity in addition to oil, ethanol, and gasoline. Moreover, using Algal Turf Scrubbers (“ATS”) in natural waterways offers …

Why We Need A Constitutional Right To Healthy Environment In Canada

Fordham Environmental Law Review

The increasing demand for constitutional recognition of the right to a healthy environment (‘RTHE’) has been a matter of public concern and debate in many countries, including Canada.2 This paper asks, will a constitutional RTHE within the Canadian Constitution add any value when statutes already exist to protect the environment (and thereby health)? The present environmental statutes work towards protecting the environment, and by protecting the environment, public health can be protected.3 Together, both of them form a ‘healthy environment’, ie., an environment that fosters a healthy life.4 This paper will argue that there is additional value in recognizing a …

The Cost Of Training A Machine: Lighting The Way For A Climate-Aware Policy Framework That Addresses Artificial Intelligence's Carbon Footprint Problem

Fordham Environmental Law Review

While artificial intelligence (AI) has been a subject of great debate in spaces such as due process, discrimination, and privacy, an area that is lacking in legal scholarship is the technology’s environmental impact. AI promises to be a silver bullet in the increasingly urgent fight against climate change, yet it comes with a considerable cost to our planet. Current industry trends involve AI models being trained on increasingly larger datasets and training methodologies that prioritize brute-force over efficiency. Thus, as AI models increase in complexity and size, so too does the computing power—and energy—required to train and deploy them. Every …

The Voice Of Azerbaijan: Experiencing Recordings Of Hajibaba Huseynov And Post-Soviet Muslim Musical Identities, Polina Dessiatnitchenko

Yale Journal of Music & Religion

Singer and poet Hajibaba Huseynov (1919–1993), revered by some as the “voice of Azerbaijan” is one of the most popular stars featured in recordings of classical devotional ghazal poetry. Curiously enough, video or audio recordings of his recitations seem to be especially moving, often becoming the focal point for audiences of musicians and poets at public live performances, private meetings, lessons, and virtual contexts. While fans of the ghazal genre are found at every turn, I limit my analysis to the subculture of poets, musicians, experts, and especially ardent fans of traditional Azerbaijani arts. Relying on ethnographic data gathered in …

Comparative Outcomes Of Transcatheter Versus Surgical Aortic Valve Replacement In Elderly Patients With Severe Symptomatic Aortic Stenosis: A Systematic Review, Omar Hamodat, Saif Almuzainy, Salma Nizar

Journal of the Saudi Heart Association

Objectives: Aortic stenosis is the most common valvular heart disease globally; while transcatheter aortic valve replacement (TAVR) has proven to be a competitive alternative to surgical aortic valve replacement (SAVR) and revolutionized treatment, its safety and efficacy has yet to be comprehensively assessed against SAVR for certain subsets of aortic stenosis patients; therefore, this study aims to systematically analyze all the available clinical evidence from randomized clinical trials on TAVR versus SAVR among intermediate and low-risk patients with severe symptomatic aortic stenosis.

Methodology: We performed a systematic review of the randomized controlled trials (RCT), studies comparing TAVR and …

Kk 44 Full Issue, Kritika Kultura

Kritika Kultura

No abstract provided.

Cloaking The Front National: Marine Le Pen, Femininity, And The Evolution Of A ‘New’ European Far-Right, Taryn M. Blecher

Claremont-UC Undergraduate Research Conference on the European Union

From the Front National to the Rassemblement National, Marine Le Pen has done what was once inconceivable in bringing France’s far-right into mainstream politics. The daughter of Le Diable (the devil), Marine Le Pen has ushered in a ‘new’ European rightwing populism—far from the Männerparteien of the past—with her femonationalism and media politics. This paper aims to increase our understanding of Marine Le Pen’s iteration of French nationalism and illusions of femininity. Through a series of illustrative case studies and supporting research, I reveal how Le Pen manipulates her sexuality and womanhood in an attempt to soften the crude image …

Assessing Paths To Greenlandic Independence: Reconciling Inuit Cultural Autonomy With Danish Rule, Leo Freedman

Claremont-UC Undergraduate Research Conference on the European Union

This analytical paper seeks to understand what political, economic, and sociocultural barriers inhibit Greenlandic independence from Denmark. The concept of independence must be conceptualized from an Inuit perspective in order to analyze what sacrifices Greenland’s largest ethnic group is willing to make to achieve an independent state. The resource extraction industry offers one path towards independence by reducing dependency on Danish and EU funding. However, this paper argues that Inuit cultural values, especially an inherent connection with the physical and spiritual health of the natural environment, is of higher value than the economic benefits of investing in the resource extraction …

The Bison, October, 11, 2024

The Bison Newspapers

No abstract provided.

Ex Vivo And In Vitro Methods As A Platform For Studying Anthropogenic Effects On Marine Mammals: Four Challenges And How To Meet Them, Juan M. Vazquez, Jane I. Khudyakov, Carla B. Madelaire, Céline A. Godard-Codding, Heli Routti, Emily K. Lam, Elizabeth R. Piotrowski, Greg B. Merrill, Jillian H. Wisse, Kaitlin N. Allen, Justin Conner, Pierre Blévin, Demetri D. Spyropoulos, Anders Goksøyr, José P. Vázquez-Medina

Pacific Faculty Work

Marine mammals are integral to global biodiversity and marine health through their roles in coastal, benthic, and pelagic ecosystems. Marine mammals face escalating threats from climate change, pollution, and human activities, which perturb their oceanic environment. The diverse biology and extreme adaptations evolved by marine mammals make them important study subjects for understanding anthropogenic pressures on marine ecosystems. However, ethical and logistical constraints restrict the tractability of experimental research with live marine mammals. Additionally, studies on the effects of changing ocean environments are further complicated by intricate gene-environment interactions across populations and species. These obstacles can be overcome with a …

Genetic Knock-In Of Eif2ak3 Variants Reveals Differences In Perk Activity In Mouse Liver And Pancreas Under Endoplasmic Reticulum Stress, Shivesh Ghura, Noah R. Beratan, Xinglong Shi, Elena Alvarez-Periel, Sarah E. Bond Newton, Cagla Akay-Espinoza, Kelly L. Jordan-Sciutto

Farber Institute for Neuroscience Staff Papers and Presentations

Common single-nucleotide variants (SNVs) of eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3) slightly increase the risk of disorders in the periphery and the central nervous system. EIF2AK3 encodes protein kinase RNA-like endoplasmic reticulum kinase (PERK), a key regulator of ER stress. Three exonic EIF2AK3 SNVs form the PERK-B haplotype, which is present in 28% of the global population. Importantly, the precise impact of these SNVs on PERK activity remains elusive. In this study, we demonstrate that PERK-B SNVs do not alter PERK expression or basal activity in vitro and in the novel triple knock-in mice expressing the exonic …

Volume Cxliv, Number 3, October 11, 2024, Lawrence University

The Lawrentian

No abstract provided.

Assessing The Impact Of Land Use Change On Carbon And Soil Quality In Kashmir Himalayas, Yasir Hanif Mir, Mumtaz A. Ganie, Zahoor A. Baba, Shakeel Mir, M. Auyoub Bhat, Javid Ahmad Bhat, Aabid H. Lone, Fehim Jeelani Wani, Shuraik Kader, Lizny Jaufer, Artan Hysa, Alban Kuriqi

Turkish Journal of Agriculture and Forestry

The Kashmir Himalayas, a region of immense ecological importance, have experienced profound degradation by land-use changes, raising concerns about sustainability. This degradation carries significant global implications, including carbon loss, soil quality deterioration, habitat destruction, and loss of biodiversity. This study investigates various key land uses, including economically vital cash crops such as apples and saffron, the socially significant staple food crop rice, forest, and pasture systems. Findings reveals that forest and pasture maintain significantly better physical, chemical, microbial, and enzymes activities, and exhibit greater soil nutrient reserves and soil organic carbon (SOC) pools. Specifically, forest soils contain 20.21%, 28.22%, and …

Global Metabolome Profiles Of Lonicera Caerulea L. And Lonicera Caerulea Ssp.Kamtschatica (Sevast.) Gladkova, Muhammad Amjad Nawaz, Mayya P. Razgonova, Elena A. Rusakova, Elena N. Petrusha, Andrey S. Sabitov, Olga A. Chunikhina, Sezai̇ Erci̇şli̇, Nadezhda G. Tikhonova, Kirill S. Golokhvast

Turkish Journal of Agriculture and Forestry

Lonicera caerulea, commonly known as honeysuckle, is widespread in the Eurasian continent. Its berries are rich in bioactive compounds. However, limited studies have explored the metabolome composition of the berries of varieties and wild accessions in different subspecies of L. caerulea. Here we studied the metabolomic compositions of four varieties of L. caerulea ssp. caerulea and one variety and five wild accessions of L. caerulea ssp. kamtschatica (Sevast.) Gladkova, by using HPLC-ESI-MS and ESI-MS/MS analyses. We report the identification of 151 compounds in the two L. caerulea subspecies. In total, 88 and 84 compounds were detected in L. caerulea and …

Change In Plant Growth And Some Bioactive Components Of The Tomato Under Water Deficit With Exogenous Chrysin Treatment, Melek Eki̇nci̇, Ertan Yildirim, Selda Örs, Meti̇n Turan, Duran Şi̇mşek, Yüsra İnci̇

Turkish Journal of Agriculture and Forestry

Drought is one of the important factors that cause a decrease in productivity and quality in plant cultivation. Stress tolerance in plants can be increased or damage can be reduced by various exogenous applications. One of them is flavonoids, which have an important role in the response to stress through changes that occur at the endogenous level in the plant due to drought stress. The effects of exogenous treatment of chrysin, a member of the flavonoid group, on tomato seedlings grown under water deficit were examined. Different doses (C0: Control with no treatment, C1: 0.1 mM, C2: 0.5 mM and …

Ventricular Interdependent Phenotype Of Mixed Cpc-Pulmonary Hypertension And Hfpef With Normal Left Atrium: Impact On Cpet Metrics And Clinical Outcome, Giovanna Zampierollo-Jaramillo, Anas Abed, Ahmed El Shaer, Mariana Garcia-Arango, Yimin Chen, Babak Tehrani, Wanxin Tu, Abdul Wahab Arif, Shannon Heffernan, Amir Esmaeeli, Aditya Sahai, James Runo, Sofia C. Masri, Farhan Raza

Division of Cardiology Faculty Papers

Among 45 CpcPH/heart failure with preserved ejection fraction participants, 11 with normal left atrium (compared to 34 with abnormal left atrium, p < 0.05 for all) had low left ventricle (LV) transmural pressure (2.9 ± 2.4 vs. 6.2 ± 2.9 mmHg), and increased right ventricle (RV):LV ratio (2.41 ± 1.09 vs. 1.46 ± 0.66) and interventricular septal angle (149 ± 8 vs. 136 ± 10), indicating exaggerated ventricular interdependence from a dilated RV

Characterization Of Bioactive Content And Aroma Compounds Of Geographical Indication İspir, Narman And Hınıs Dry Beans, Erkan Denk, Razi̇ye Kul, Nesi̇be Ebru Kafkas, Hülya Ünver, Zühal Okcu, Doğan Ergün, Tahani Awad Alahmadi, Mohammad Javed Ansari

Turkish Journal of Agriculture and Forestry

This study aimed to define the aroma components, antioxidant activity, total phenol, and sugar contents of three geographicallyindicated dry beans: İspir Dry Bean, Narman Sugar Bean, and Hınıs Bean. Significant differences were found among three different drybeans in terms of total phenolic content, total antioxidant capacity (2,2-diphenyl-1-picrylhydrazil test), sugar content, and volatilecompounds. The total phenolic content ranged from 14.09 mg gallic acid equivalents per 100 g dry bean sample in Narman to 36.73 mgin Hınıs. The highest total antioxidant activity was observed in İspir Bean with 8.38%, while the lowest was in Narman Bean with 6.02%.Additionally, the total sugar contents …

The Student Movement Volume 109 Issue 4: 'Twas The Night (Market) Before Fall Break, John Roosenberg, Alyssa Caruthers, Esther Martin, Savannah Tyler, Aiko J. Ayala Rios, Addison Randall, Ember Clark, Rod Olofernes, Amelia Stefanescu, Melissa Moore, Melanie Webb, Charisse Lapuebla, Timi Olatunde, Lexie Dunham, Anna Rybachek

The Student Movement V. 109 (2024-2025)

HUMANS

AULA Brings Students Closer to Home, John Roosenberg

New Basketball Coach Jared Rusher on Returning to Andrews, Alyssa Caruthers

Dorm Pets, Esther Martin

Cardinals Enter Stage Left: An Intro to the Andrews University Theatre Wing, Interviewed by Savannah Tyler

ARTS & ENTERTAINMENT

Mozart's New Banger: Classical Music in Today's World, Aiko J. Ayala Rios

An Intro to the Music Department and How You Can Get Involved, Addison Randall

Nationalism and Warfare: A Review of Edward Hall's 'Henry V', Ember Clark

NEWS

Leadership Conference Inspires Andrews' Leaders, Rod Olofernes

Fairy Lights, Pancit, and Guaraná: Night Market at AU: Amelia Stefanescu …

Significance Of Honeybee Pollination In Increasing Seed Yield Of Trifolium Alexandrinum (Fabales: Fabaceae) And Its Impact On Economic Sustainability Of Smallholder Farmers, Muhammad Shoaib Tufail, Gaye L. Krebs, Alison Southwell, John Piltz, Peter C. Wynn, David F. Cook

Grain and Other Field Crops Research Articles

A major limitation to producing high seed yields in berseem clover (Trifolium alexandrinum L.) is failure to set seed, predominantly due to lack of pollination. Despite the importance of berseem clover as a leading forage legume, the contribution of pollinators to seed set is scarce. In Pakistan, the honeybee population is declining mainly because of the extensive use of neonicotinoid pesticides and habitat fragmentation. This, combined with the region’s harsh environment and the use of inferior, locally bred genotypes, has resulted in low seed yields. Insufficient seed availability leads to limited forage supply, resulting in poor livestock nutrition, which …

South Sudanese Females Refugees' Access And Enrolment Into U. S. Post-Secondary Education., Kual Ayai

Walden Dissertations and Doctoral Studies

South Sudanese Females Refugees’ Access and Enrolment into U.S. Post-Secondary Education There are considerable challenges experienced by female South Sudanese refugees to access post-secondary education in the United States. Although these challenges are many, but little was known about their experiences to access and enrol into US post-secondary education. There has been a significant lack of research on how South Sudanese female refugees overcome these challenges to access and enrol in US secondary education. The purpose of this phenomenological qualitative study was to gain a deeper understanding of the challenges experienced by South Sudanese female refugees to access and enrol …

Developing Accurate And Automated High-Field And Benchtop Nmr-Based Metabolomic Techniques Using Neural Networks, Hayden Johnson

Electronic Theses and Dissertations Archive

NMR-based metabolomics is an increasingly important tool for understanding organisms and biological systems; however, data processing is an often-tedious process and access to high-field NMR spectrometers is limited. Conventional data processing for metabolite profiling relies on slow, user-dependent analysis, yet modern artificial intelligence techniques have scantly been explored in quantitative NMR applications despite their industry transforming effects in many major data processing applications. This work aims to develop neural network approaches to fully automate the identification and quantification of metabolites from NMR spectra while increasing speed and throughput compared to conventional analysis. Our initial investigation implements neural networks for the …

The Occurrence And Variations Of Total Aflatoxins And Aflatoxin B1 In Different Types Of Chicken Feeds Marketed In Dar Es Salaam, Tanzania, Mambaga S. Muja, Regina P. Mtei, Kessy F. Kilulya

Tanzania Journal of Science

This paper reports on the occurrence and variation of total aflatoxins (TAF) and aflatoxin B1 (AFB1) in different types of chicken feeds collected from various locations in Dar es Salaam. A total of 63 chicken feed samples based on cotton seed hulls, sunflower seed hulls, maize bran and mixed feeds were analysed using HPLC-FLD. It was revealed that all samples were contaminated with both TAF and AFB1, varying significantly with respect to their types. Specifically, 52.9% of the cotton seed hulls and 64.7% of maize bran samples exceeded the set tolerable limit of 5 ng g−1 for AFB1. All sunflower …