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2024

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Evaluation Of Alkaloid Levels In Commercial And Wild Genotypes Of Narrow-Leafed Lupin, Tawfeek Khedr, Ling Ling Gao, Lars G. Kamphuis, Utpal Bose, Angéla Juhász, Michelle L. Colgrave Nov 2024

Evaluation Of Alkaloid Levels In Commercial And Wild Genotypes Of Narrow-Leafed Lupin, Tawfeek Khedr, Ling Ling Gao, Lars G. Kamphuis, Utpal Bose, Angéla Juhász, Michelle L. Colgrave

Research outputs 2022 to 2026

Lupins are a promising source of protein that can complement soybean-based proteins in food and animal feed. Narrow-leafed lupin (Lupinus angustifolius) is the predominant lupin species cultivated in Australia and Europe. Consumption of lupin products can lead to toxicity in both humans and animals, primarily due to the presence of naturally occurring alkaloid compounds. The aim of the present research was to examine the alkaloid content of commercial narrow-leafed lupin grown in Australia and compare this to wild accessions. Nineteen accessions of narrow-leafed lupin were grown in a growth chamber with a day/night cycle of 18 h of light and …


Mouse Mammary Tumor Virus (Mmtv) Genomic Rna (Grna) Packaging: Selective Grna Encapsidation Is Facilitated By Long-Range Interactions (Lris) That Facilitate Specific Gag Binding, Suresha G. Prabhu Nov 2024

Mouse Mammary Tumor Virus (Mmtv) Genomic Rna (Grna) Packaging: Selective Grna Encapsidation Is Facilitated By Long-Range Interactions (Lris) That Facilitate Specific Gag Binding, Suresha G. Prabhu

Dissertations

Mouse mammary tumor virus (MMTV) is a betaretrovirus that induces breast cancer and sporadically, T-cell lymphomas in mice. MMTV serves as a pertinent model for elucidating the mechanism(s) of oncogenesis and the genetics associated with the development of mammary tumors. Being a rodent retrovirus, MMTV is phylogenetically distant from human and other primate retroviruses; thus, positioning it ideally as a potential vector of choice for human gene therapy. This may circumvent safety concerns such as recombination with other related endogenous human retroviruses. In addition, MMTV is distinct from most other retroviruses, but similar to lentiviruses, in that it has the …


Pollination By Birds, Non-Flying Mammals, And European Honeybees In A Heathland Shrub, Banksia Catoglypta (Proteaceae), Stanislaw K. Wawrzyczek, Robert A. Davis, Siegfried L. Krauss, Susan E. Hoebee, Louis M. Ashton, Ryan D. Phillips Nov 2024

Pollination By Birds, Non-Flying Mammals, And European Honeybees In A Heathland Shrub, Banksia Catoglypta (Proteaceae), Stanislaw K. Wawrzyczek, Robert A. Davis, Siegfried L. Krauss, Susan E. Hoebee, Louis M. Ashton, Ryan D. Phillips

Research outputs 2022 to 2026

Vertebrate pollination has evolved in many plant lineages, with pollination by birds the most prevalent strategy. However, in Banksia (Proteaceae) many species are visited by a combination of nectarivorous birds, non-flying mammals (NFMs), and insects, though the relative importance of these pollen vectors for reproduction remains poorly understood. Here, we investigate the contribution to fruit set of birds, NFMs, and insects in Banksia catoglypta—a heathland shrub from south-west Australia. This species flowers in winter and produces large, golden-yellow inflorescences that are typically presented near the ground and consist of rigid, strongly scented flowers with a long stigma-nectary distance—suggesting pollination by …


Glymphatic Dysfunction In Multiple Sclerosis And Its Association With Disease Pathology And Disability, Ahmed Bayoumi, Khader M Hasan, Joseph A Thomas, Akram Yazdani, John A Lincoln Nov 2024

Glymphatic Dysfunction In Multiple Sclerosis And Its Association With Disease Pathology And Disability, Ahmed Bayoumi, Khader M Hasan, Joseph A Thomas, Akram Yazdani, John A Lincoln

Faculty, Staff and Student Publications

Background: The role of the glymphatic system in multiple sclerosis (MS)-related disability remains underexplored. Diffusion-tensor image analysis along the perivascular space (DTI-ALPS) offers a non-invasive method to assess glymphatic function.

Objective: To evaluate glymphatic function in MS patients with lower and higher disability.

Methods: This study included 118 MS patients who underwent structural, diffusion-weighted imaging, and clinical assessment. The participants were divided into lower (MS-L, n = 57) and higher disability (MS-H, n = 61) subgroups. Brain parenchymal fraction (BPF), lesion load (LL), and DTI-ALPS index were measured. Subgroup differences and correlations between DTI-ALPS index and other measures were explored. …


An Exploratory Vector Field Analysis Of Ground Reaction Force During Maximum Sprinting Efforts In Male Soccer Players And Sprinters, Daniel Kadlec, Steffi Colyer, Ryu Nagahara, Sophia Nimphius Nov 2024

An Exploratory Vector Field Analysis Of Ground Reaction Force During Maximum Sprinting Efforts In Male Soccer Players And Sprinters, Daniel Kadlec, Steffi Colyer, Ryu Nagahara, Sophia Nimphius

Research outputs 2022 to 2026

The ability to accelerate and attain high velocities is essential for both individual and team sport athletes. The purpose of this explorative study was to retrospectively analyze the ground reaction force using Statistical Parametric Mapping (SPM) vector field analysis, as traditional scalar analyses often fail to acknowledge the interdependence of force vector components. The ground reaction force vector and the scalar components (i.e., vertical and horizontal force) were analyzed for 28 male sprinters and 24 male soccer players at 8.0 and 8.5 m·s−1, and between 85%, 90%, 95%, and 100% of their maximum velocity. The ground reaction force vector differed …


The Role Of Bone In Energy Metabolism: A Focus On Osteocalcin, Cassandra Smith, Xuzhu Lin, Lewan Parker, Bu B. Yeap, Alan Hayes, Itamar Levinger Nov 2024

The Role Of Bone In Energy Metabolism: A Focus On Osteocalcin, Cassandra Smith, Xuzhu Lin, Lewan Parker, Bu B. Yeap, Alan Hayes, Itamar Levinger

Research outputs 2022 to 2026

Understanding the mechanisms involved in whole body glucose regulation is key for the discovery of new treatments for type 2 diabetes (T2D). Historically, glucose regulation was largely focused on responses to insulin and glucagon. Impacts of incretin-based therapies, and importance of muscle mass, are also highly relevant. Recently, bone was recognized as an endocrine organ, with several bone proteins, known as osteokines, implicated in glucose metabolism through their effects on the liver, skeletal muscle, and adipose tissue. Research efforts mostly focused on osteocalcin (OC) as a leading example. This review will provide an overview on this role of bone by …


Collectively Advancing Deep Learning For Animal Detection In Drone Imagery: Successes, Challenges, And Research Gaps, Daniel Axford, Ferdous Sohel, Mathew A. Vanderklift, Amanda J. Hodgson Nov 2024

Collectively Advancing Deep Learning For Animal Detection In Drone Imagery: Successes, Challenges, And Research Gaps, Daniel Axford, Ferdous Sohel, Mathew A. Vanderklift, Amanda J. Hodgson

Research outputs 2022 to 2026

Drones have emerged as a powerful tool in animal detection, significantly advancing wildlife monitoring, conservation, and management by capturing high-resolution, real-time imagery over areas often inaccessible or challenging for human observers to reach. However, manual analysis of drone imagery for animal detection is labour-intensive and time-consuming. The application of deep learning methods, particularly convolutional neural networks, in automating animal detection from drone imagery has the potential to revolutionise wildlife monitoring, conservation, and management protocols. This review provides a comprehensive overview of the increasing use and prospects of deep learning in animal detection using drone imagery. It explores successful applications of …


Prevalence Trends Of Foodborne Pathogens Bacillus Cereus, Non-Stec Escherichia Coli And Staphylococcus Aureus In Ready-To-Eat Foods Sourced From Restaurants, Cafés, Catering And Takeaway Food Premises, Nicole Foxcroft, Edmore Masaka, Jacques Oosthuizen Nov 2024

Prevalence Trends Of Foodborne Pathogens Bacillus Cereus, Non-Stec Escherichia Coli And Staphylococcus Aureus In Ready-To-Eat Foods Sourced From Restaurants, Cafés, Catering And Takeaway Food Premises, Nicole Foxcroft, Edmore Masaka, Jacques Oosthuizen

Research outputs 2022 to 2026

Foodborne pathogens of Bacillus cereus (B. cereus), non-STEC Escherichia coli (non-STEC E. coli) and Staphylococcus aureus (S. aureus) are currently non-notifiable in Australia unless attributed to a food poisoning outbreak. Due to the lack of data around individual cases and isolations in foods, any changes in prevalence may go undetected. The aim of this study was to determine any changes in the prevalence of B. cereus, non-STEC E. coli and S. aureus in ready-to-eat (RTE) foods sampled from Western Australian restaurants, cafés, catering facilities and takeaway food premises from July 2009 to June 2022. A total of 21,822 microbiological test …


Connecting Community And Family Philanthropy In Latin America: Mexico, Dorothy A. Johnson Center For Philanthropy At Grand Valley State Universit, Michael D. Layton, Michael Moody Nov 2024

Connecting Community And Family Philanthropy In Latin America: Mexico, Dorothy A. Johnson Center For Philanthropy At Grand Valley State Universit, Michael D. Layton, Michael Moody

Research, Reports, and Publications

This report explores the dynamics of community philanthropy and family philanthropy in Mexico in order to inform efforts to strengthen the connection between the two. In terms of community philanthropy, our primary focus is upon Mexico’s community foundation model, which is the most institutionalized form of community philanthropy and a uniquely important actor in the philanthropic ecosystem. Wealthy families and family businesses in Mexico are known to have strong local ties and to prioritize place-based development, and Mexico has more community foundations than any other Latin American country. In terms of family philanthropy, we have cast a wider net, interviewing …


Trade-Offs In A Reef-Building Coral After Six Years Of Thermal Acclimation, Anna Roik, Marlene Wall, Melina Dobelmann, Samuel Nietzer, Anna Fiesinger, Miriam Reverter, David Brefeld, Peter J Schupp, Matthew Jackson, Marie Rutsch, Julia Strahl Nov 2024

Trade-Offs In A Reef-Building Coral After Six Years Of Thermal Acclimation, Anna Roik, Marlene Wall, Melina Dobelmann, Samuel Nietzer, Anna Fiesinger, Miriam Reverter, David Brefeld, Peter J Schupp, Matthew Jackson, Marie Rutsch, Julia Strahl

School of Biological and Marine Sciences

There is growing evidence that reef-building corals can acclimate to novel and challenging thermal conditions. However, potential trade-offs that accompany acclimation remain largely unexplored. We investigated physiological trade-offs in colonies of a globally abundant coral species (Pocillopora acuta) that were acclimated ex situ to an elevated temperature of 31 °C (i.e., 1 °C above their bleaching threshold) for six years. By comparing them to conspecifics maintained at a cooler temperature, we found that the energy storage of corals was prioritized over skeletal growth at the elevated temperature. This was associated with the formation of higher density skeletons, lower calcification rates …


Advancing Crispr-Based Solutions For Covid-19 Diagnosis And Therapeutics, Roaa Hadi, Abhishek Poddar, Shivakuma Sonnaila, Venkata Suryanarayana Murthy Bhavaraju, Shilpi Agrawal Nov 2024

Advancing Crispr-Based Solutions For Covid-19 Diagnosis And Therapeutics, Roaa Hadi, Abhishek Poddar, Shivakuma Sonnaila, Venkata Suryanarayana Murthy Bhavaraju, Shilpi Agrawal

Chemistry & Biochemistry Faculty Publications and Presentations

Since the onset of the COVID-19 pandemic, a variety of diagnostic approaches, including RT-qPCR, RAPID, and LFA, have been adopted, with RT-qPCR emerging as the gold standard. However, a significant challenge in COVID-19 diagnostics is the wide range of symptoms presented by patients, necessitating early and accurate diagnosis for effective management. Although RT-qPCR is a precise molecular technique, it is not immune to false-negative results. In contrast, CRISPR-based detection methods for SARS-CoV-2 offer several advantages: they are cost-effective, time-efficient, highly sensitive, and specific, and they do not require sophisticated instruments. These methods also show promise for scalability, enabling diagnostic tests. …


The Erosion Of Identity: A Study Of The Influence Of Racial Microaggressions On K-12 African American School Leaders, Rayfield J. Lavan Iii Nov 2024

The Erosion Of Identity: A Study Of The Influence Of Racial Microaggressions On K-12 African American School Leaders, Rayfield J. Lavan Iii

Electronic Theses and Dissertations

This qualitative study explored the experiences of African American educational leaders in navigating racial microaggressions in the workplace, specifically within K-12 educational settings. Using Taxonomy of Racial Microaggressions and emotion regulation theory as frameworks, this research examines how these leaders manage, respond to, and cope with various forms of racial bias while maintaining their professional identities. Data were collected through in-depth interviews with African American leaders, and thematic analysis was used to identify recurring patterns of microaggressions and corresponding emotion regulation strategies. Key findings reveal that participants frequently encounter microaggressions such as assumption of inferiority, criminality, and second-class citizenship, with …


Dispositional Optimism, Sleep, And Trait Affective Mediators: A Latent Variable Approach, Nicole Ruiying Chen, Nadyanna Binte Mohamed Majeed, Adalia Yin Hui Goh, Paye Shin Koh, Jonathan Louis Jie Sheng Chia, Andree Hartanto Nov 2024

Dispositional Optimism, Sleep, And Trait Affective Mediators: A Latent Variable Approach, Nicole Ruiying Chen, Nadyanna Binte Mohamed Majeed, Adalia Yin Hui Goh, Paye Shin Koh, Jonathan Louis Jie Sheng Chia, Andree Hartanto

Research Collection School of Social Sciences

Dispositional optimism has been shown to be associated with better sleep. However, most existing studies rely on subjective assessments of sleep, which may not align with objective assessments of sleep. Additionally, research investigating the mechanisms underlying the association between optimism and sleep is lacking. Moreover, the confounding role of possible content overlap in measures relevant to the constructs of interest has been neglected. To address these gaps, we utilised latent variable analysis and investigated the mediating role of depression and trait anxiety across two large-scale studies (total N = 2312), with objective sleep measures included in Study 2. In Study …


From Sustainable Agriculture To Sustainable Agrifood Systems: A Comparative Review Of Alternative Models, Qian Forrest Zhang Nov 2024

From Sustainable Agriculture To Sustainable Agrifood Systems: A Comparative Review Of Alternative Models, Qian Forrest Zhang

Research Collection School of Social Sciences

This paper reviews, compares, and critically evaluates two broad groups of sustainable agriculture models: “sustainable agriculture” and “sustainable agrifood systems”. The “sustainable agriculture” models—comprising organic farming, regenerative agriculture, climate-smart agriculture, carbon-capture agriculture, and nature-based solutions—focus primarily on improving ecological sustainability through farm-level practices. These models emphasize reducing external, industrial inputs, enhancing biodiversity, and promoting climate resilience, relying on technological and market-based solutions to address environmental concerns. On the other hand, the “sustainable agrifood systems” models—agroecology, alternative food networks, and permaculture—offer more ambitious visions of systemic transformation. These approaches not only seek to implement environmentally sound practices but also aim to …


Bacillus Licheniformis Suppresses Clostridium Perfringens Infection Via Modulating Inflammatory Response, Antioxidant Status, Inflammasome Activation And Microbial Homeostasis In Broilers, Xiao Xiao, Songke Qin, Tiantian Cui, Jinsong Liu, Yanping Wu, Yifan Zhong, Caimei Yang Nov 2024

Bacillus Licheniformis Suppresses Clostridium Perfringens Infection Via Modulating Inflammatory Response, Antioxidant Status, Inflammasome Activation And Microbial Homeostasis In Broilers, Xiao Xiao, Songke Qin, Tiantian Cui, Jinsong Liu, Yanping Wu, Yifan Zhong, Caimei Yang

Faculty, Staff and Student Publications

Pathogenic bacteria infection, especially Clostridium perfringens (C. perfringens), markedly threatened the health of animals, and further caused huge economic loss. In this study, Bacillus licheniformis HJ0135 (BL) was used. Oxford cup bacteriostatic test and inhibitory rate test were conducted to evaluate the antibacterial ability of BL. Results showed the strongest inhibitory role of BL on C. perfringens (P < 0.05). Afterwards, 540 one-day-old yellow-feather broilers (32.7 ± 0.2 g) were randomly allocated into 3 groups, including CON group (basal diet), CP group (basal diet + 1 × 109 CFU C. perfringens in gavage), and BL + CP group (basal diet containing 7.5 × 106 CFU/g BL + 1 × 109 CFU C. perfringens in gavage). At d 70, broilers in the CP and BL + CP groups were treated with C. perfringens by continuously oral administration for 5 d. The experiment lasted for 75 d. The serum, immune organs, jejunal mucosa, and cecal contents were collected for analysis. In vivo experiment showed that BL supplementation markedly improved (P < 0.05) BW, ADG, thymus index, serum immunoglobins and antioxidases, reduced feed conversion ratio (FCR) and serum pro-inflammatory cytokines of C. perfringens-infected broilers. Furthermore, the increased jejunal injury and levels of pro-inflammatory cytokines, decreased gene expressions of tight junction proteins in the jejunal mucosa were significantly alleviated (P < 0.05) by BL. More importantly, the activation of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome was inhibited (P < 0.05) by BL to further attenuate jejunal damage. Besides, BL supplementation markedly increased (P < 0.05) the cecal isobutyric acid and isovaleric acid. Microbial analysis showed that BL changed the composition and relative abundances of microbiota in the cecal contents (P < 0.05), especially the short chain fatty acids (SCFAs)-producing bacteria including Eubacterium_coprostanoligenes_group, Megamonas, Faecalibacterium, and Lactobacillus, which further protected against C. perfringens-induced jejunal inflammation in broilers. Our study laid a theoretical basis for the application of probiotics in lessening C. perfringens-related diseases in poultry farming.


Hu8f4-Car T Cells With Mutated Fc Spacer Segment Improve Target Specificity And Mediate Anti-Leukemia Activity In Vivo, Hong He, Rolando A Vedia, Sijie Lu, Qiaochuan Li, Kathryn R Cox, Lisa St John, Anna Sergeeva, Karen Clise-Dwyer, Gheath Alatrash, Elizabeth J Shpall, Qing Ma, Jeffrey J Molldrem Nov 2024

Hu8f4-Car T Cells With Mutated Fc Spacer Segment Improve Target Specificity And Mediate Anti-Leukemia Activity In Vivo, Hong He, Rolando A Vedia, Sijie Lu, Qiaochuan Li, Kathryn R Cox, Lisa St John, Anna Sergeeva, Karen Clise-Dwyer, Gheath Alatrash, Elizabeth J Shpall, Qing Ma, Jeffrey J Molldrem

Faculty, Staff and Student Publications

Background aims: Hu8F4 is a T-cell receptor-like antibody with high affinity for the leukemia-associated antigen PR1/HLA-A2 epitope. Adapted into a chimeric antigen receptor (CAR) format, Hu8F4-CAR is composed of the Hu8F4 single-chain variable fragment, the human IgG1 CH2CH3 extracellular spacer domain, a human CD28 costimulatory domain and the human CD3ζ signaling domain. We have demonstrated high efficacy of Hu8F4-CAR-T cells against PR1/HLA-A2-expressing cell lines and leukemic blasts from patients with acute myeloid leukemia in vitro. Previous studies have shown that modification of the Fc domains of IgG4 CH2CH3 spacer regions can eliminate activation-induced cell death and off-target killing mediated by …


Uterine-Conserving Treatment Options For Atypical Endometrial Hyperplasia And Early Endometrial Cancer, Naomi N Adjei, Mikayla Borthwick Bowen, Roni Nitecki Wilke, Melinda S Yates, Shannon N Westin Nov 2024

Uterine-Conserving Treatment Options For Atypical Endometrial Hyperplasia And Early Endometrial Cancer, Naomi N Adjei, Mikayla Borthwick Bowen, Roni Nitecki Wilke, Melinda S Yates, Shannon N Westin

Faculty, Staff and Student Publications

Purpose of review: This review aims to synthesize available literature on uterine-conserving treatment options for atypical endometrial hyperplasia and grade 1 endometrial carcinoma while highlighting remaining unanswered questions.

Recent findings: The need for uterine-conserving treatment options for atypical endometrial hyperplasia and grade 1 endometrial carcinoma is growing with the increasing number of cases in younger patients or those who cannot undergo surgery. We reviewed the oncological and reproductive outcomes associated with endocrine therapies used for atypical endometrial hyperplasia and grade 1 endometrial carcinoma. The rising prevalence of delayed childbearing, obesity, and diabetes in reproductive-age individuals and of medical comorbidities associated …


Calcineurin Inhibition Enhances Caenorhabditis Elegans Lifespan By Defecation Defects-Mediated Calorie Restriction And Nuclear Hormone Signaling, Priyanka Das, Alejandro Aballay, Jogender Singh Nov 2024

Calcineurin Inhibition Enhances Caenorhabditis Elegans Lifespan By Defecation Defects-Mediated Calorie Restriction And Nuclear Hormone Signaling, Priyanka Das, Alejandro Aballay, Jogender Singh

Faculty, Staff and Student Publications

Calcineurin is a highly conserved calcium/calmodulin-dependent serine/threonine protein phosphatase with diverse functions. Inhibition of calcineurin is known to enhance the lifespan of Caenorhabditis elegans through multiple signaling pathways. Aiming to study the role of calcineurin in regulating innate immunity, we discover that calcineurin is required for the rhythmic defecation motor program (DMP) in C. elegans. Calcineurin inhibition leads to defects in the DMP, resulting in intestinal bloating, rapid colonization of the gut by bacteria, and increased susceptibility to bacterial infection. We demonstrate that intestinal bloating caused by calcineurin inhibition mimics the effects of calorie restriction, resulting in enhanced lifespan. …


Therapeutic Targeting Of Hypoxia Inducible Factor In Acute Respiratory Distress Syndrome, Thu T Tran, Holger K Eltzschig, Xiaoyi Yuan Nov 2024

Therapeutic Targeting Of Hypoxia Inducible Factor In Acute Respiratory Distress Syndrome, Thu T Tran, Holger K Eltzschig, Xiaoyi Yuan

Faculty, Staff and Student Publications

Acute respiratory distress syndrome (ARDS) is characterized by bilateral chest infiltration and acute hypoxic respiratory failure. ARDS carries significant morbidity and mortality despite advancements in medical management, calling for the development of novel therapeutic targets. Hypoxia-inducible factor (HIF) is a heterodimeric protein involved in various essential pathways, including metabolic reprogramming, immune modulation, angiogenesis and cell cycle regulation. HIF is routinely degraded in homeostasis conditions via the prolyl hydroxylase domain/von Hippel-Lindau protein pathway. However, HIF is stabilized in ARDS via various mechanisms (oxygen-dependent and independent) as an endogenous protective pathway and plays multifaceted roles in different cell populations. This review focuses …


Concurrent Optogenetic Motor Mapping Of Multiple Limbs In Awake Mice Reveals Cortical Organization Of Coordinated Movements, Nischal Khanal, Jonah A Padawer-Curry, Trevor Voss, Kevin A Schulte, Annie R Bice, Adam Q Bauer Nov 2024

Concurrent Optogenetic Motor Mapping Of Multiple Limbs In Awake Mice Reveals Cortical Organization Of Coordinated Movements, Nischal Khanal, Jonah A Padawer-Curry, Trevor Voss, Kevin A Schulte, Annie R Bice, Adam Q Bauer

2020-Current year OA Pubs

BACKGROUND: Motor mapping allows for determining the macroscopic organization of motor circuits and corresponding motor movement representations on the cortex. Techniques such as intracortical microstimulation (ICMS) are robust, but can be time consuming and invasive, making them non-ideal for cortex-wide mapping or longitudinal studies. In contrast, optogenetic motor mapping offers a rapid and minimally invasive technique, enabling mapping with high spatiotemporal resolution. However, motor mapping has seen limited use in tracking 3-dimensonal, multi-limb movements in awake animals. This gap has left open questions regarding the underlying organizational principles of motor control of coordinated, ethologically-relevant movements involving multiple limbs.

OBJECTIVE: Our …


Evidence Of Human Bourbon Virus Infections, North Carolina, Usa, Diana L Zychowski, Gayan Bamunuarachchi, Scott P Commins, Ross M Boyce, Adrianus C M Boon Nov 2024

Evidence Of Human Bourbon Virus Infections, North Carolina, Usa, Diana L Zychowski, Gayan Bamunuarachchi, Scott P Commins, Ross M Boyce, Adrianus C M Boon

2020-Current year OA Pubs

Bourbon virus is a tickborne virus that can cause human disease. Cases have been reported in Kansas, Oklahoma, and Missouri, USA. We identified Bourbon virus-specific neutralizing antibodies in patients from North Carolina. Bourbon virus infections are likely more common than previously thought, highlighting the need for improved diagnostics and surveillance.


Taxation’S Limits, Luís C. Calderón Gómez Nov 2024

Taxation’S Limits, Luís C. Calderón Gómez

Articles

Countless pages have been devoted to the question of why everyone should pay tax, yet its opposite has gone largely unnoticed: why should some people and organizations not pay tax? Our tax system exempts from ordinary income taxation a wide and diverse array of people and organizations engaged in significant economic activity—from parents providing childcare services for their family to consular activities and charities operating animal shelters—seemingly without a convincing explanation. Perhaps because of the dizzying diversity of tax-exempt activities, scholars and policymakers have avoided comprehensively or coherently justifying our exemption regimes.

This Article develops a novel normative theory that …


Localized Intratumoral Delivery Of Immunomodulators For Oral Cancer And Oral Potentially Malignant Disorders, Nourhan I Hussein, Andrea H Molina, Gemalene M Sunga, Moran Amit, Yu Leo Lei, Xiao Zhao, Jeffrey D Hartgerink, Andrew G Sikora, Simon Young Nov 2024

Localized Intratumoral Delivery Of Immunomodulators For Oral Cancer And Oral Potentially Malignant Disorders, Nourhan I Hussein, Andrea H Molina, Gemalene M Sunga, Moran Amit, Yu Leo Lei, Xiao Zhao, Jeffrey D Hartgerink, Andrew G Sikora, Simon Young

Faculty, Staff and Student Publications

Immunotherapy has developed into an important modality of modern cancer treatment. Unfortunately, checkpoint inhibitor immunotherapies are currently delivered systemically and require frequent administration, which can result in toxicity and severe, sometimes fatal, adverse events. Localized delivery of immunomodulators for oral cancer and oral potentially malignant disorders offers the promise of maximum therapeutic potential and reduced systemic adverse effects. This review will discuss the limitations of current standard-of-care systemic therapies and highlight research advances in localized, intratumoral delivery platforms for immunotherapy for oral cancer and oral potentially malignant disorders.


Championing Food Studies Within The Field Of Irish Studies: A Serendipitous Autoethnographic Journey, Mairtin Macconiomaire Nov 2024

Championing Food Studies Within The Field Of Irish Studies: A Serendipitous Autoethnographic Journey, Mairtin Macconiomaire

Doctoral

Food permeates every aspect of life and society, from birth to death—from the new-born’s first suckle to the food traditions associated with Irish wakes and funerals. Essential for survival, it has historically proven academically elusive, hidden in plain sight. Entangled with the domestic and the feminine, it was traditionally regarded as too mundane and too quotidian for consideration. Depending on how you define it, Irish Studies has somewhere between 50 and 100 years of history as an academic discipline. Food Studies is a more recent academic phenomenon, which has been steadily growing internationally since last decade of the twentieth century. …


Polyphenol Profiling And Bioactivities Of Date Seed: A Comparative Assessment Of Extraction Techniques In Different Date Seed Varieties, Fatima Ibrahim Albedwawi Nov 2024

Polyphenol Profiling And Bioactivities Of Date Seed: A Comparative Assessment Of Extraction Techniques In Different Date Seed Varieties, Fatima Ibrahim Albedwawi

Theses

Plant-waste-derived bioactive compounds have generated growing interest recently. In this context, this project examined the phenolic content, antioxidant capacity, antimicrobial activity, and antibiofilm capability of the seed extract of Phoenix dactylifera. Six date seed varieties (Fardh, Sukarri, Negal, Majdool, Zahidi, and Khadrawy) were studied. In this study, a novel ultrasound-assisted extraction technique is compared with the conventional extraction method (maceration using 80% ethanol), taking into account both the quality and quantity of polyphenols. Among the primary objectives, the ultrasound-assisted extraction (UAE) of polyphenols was optimized using response surface methodology (RSM), aiming for maximum TPC and DPPH radical scavenging. By …


Assessment Of Heavy Metal Concentration In Orange-Spotted Trevally (Flavocaranx Bajad) From Two Coastal Locations In Abu Dhabi, United Arab Emirates, Kholood Khaled Aljaberi Nov 2024

Assessment Of Heavy Metal Concentration In Orange-Spotted Trevally (Flavocaranx Bajad) From Two Coastal Locations In Abu Dhabi, United Arab Emirates, Kholood Khaled Aljaberi

Theses

This study investigates concentration of heavy metals in the Orange-spotted Trevally (Flavocaranx bajad) from two distinct coastal areas in Abu Dhabi Emirate, Sila and Abu Dhabi. Heavy metals pollution poses a significant risk to both marine ecosystems and human health; thus it is vital to conduct comprehensive assessments of heavy metal contaminations in aquatic life. The main aim of this study is to quantify the levels of heavy metals and assess their concentrations in gill, muscle, and liver tissues of the Orange-spotted Trevally from both sites. The samples were prepared and analyzed using microwave digestion system and ICP …


Evaluation Of Opportunities For The Cultivation Of Heterotrophic Plant Root Organ Cultures As Food: Optimization Of Culture Conditions And Carbohydrate Sources, Fatima Mohammed Alkaabi Nov 2024

Evaluation Of Opportunities For The Cultivation Of Heterotrophic Plant Root Organ Cultures As Food: Optimization Of Culture Conditions And Carbohydrate Sources, Fatima Mohammed Alkaabi

Theses

All agricultural plant production requires investment of water, energy, and land, especially in the Gulf Region, where environmental conditions are not ideally suitable for crop farming. Currently, less than 40% of agricultural plant biomass production constitutes food, which greatly limits the overall feasibility of food production systems worldwide. Crop residues constitute over half of global agricultural biomass, and food waste and biomass from public parks and gardens further add to the vast pool of non-edible plant material. Existing valorization strategies for such material cannot compensate for the enormous amounts of water, energy, land, and human resources invested in their production. …


Neutrosophic Logic-Based Crop Yield Prediction And Risk Assessment Using Least Squares Regression, M. Srikanth, R.N.V. Jagan Mohan, M. Chandra Naik Nov 2024

Neutrosophic Logic-Based Crop Yield Prediction And Risk Assessment Using Least Squares Regression, M. Srikanth, R.N.V. Jagan Mohan, M. Chandra Naik

Neutrosophic Systems with Applications

Agriculture faces significant challenges due to climate change and unpredictable environmental factors, which impact crop yields and threaten food security. This study proposes a novel approach to crop yield prediction and risk assessment using neutrosophic logic and least squares regression. By integrating these methods, we aim to improve accuracy in predicting crop losses under uncertain conditions. The model classifies crops based on profitability and environmental risks, utilizing the independence test to evaluate the relationships between crop attributes. Our approach leverages deep learning techniques, such as restricted Boltzmann machines (RBM), to enhance the analysis of crop data and provide farmers with …


Product Perspective From Fuzzy To Neutrosophic Graph Extension- A Review Of Literature, G. Vetrivel, M. Mullai, G. Rajchakit Nov 2024

Product Perspective From Fuzzy To Neutrosophic Graph Extension- A Review Of Literature, G. Vetrivel, M. Mullai, G. Rajchakit

Neutrosophic Systems with Applications

This review article consolidates and tabulates research on the product operations done in fuzzy, intuitionistic fuzzy, and neutrosophic graphs. This article encompasses the previous product discussions on fuzzy graphs and their extensions. This article aims to list the origin, structural properties, applications, etc. done by the researchers and academicians using the product behavior of two graphs on the fuzzified environment. This review provides a clear understanding of enhancements of product approach on graphs from fuzzy to neutrosophic kind.


A Neutrosophic Model For Measuring Evolution, Involution, And Indeterminacy In Species: Integrating Common And Uncommon Traits In Environmental Adaptation, Antonios Paraskevas, Michael Madas Nov 2024

A Neutrosophic Model For Measuring Evolution, Involution, And Indeterminacy In Species: Integrating Common And Uncommon Traits In Environmental Adaptation, Antonios Paraskevas, Michael Madas

Neutrosophic Systems with Applications

In 2017, Professor F. Smarandache introduced the Neutrosophic Theory of Evolution, Involution, and Indeterminacy (or Neutrality) (NToEIaI). He concluded that every theory of evolution is characterized by a certain degree of truth, indeterminacy, and untruth, as in neutrosophic logic. In this perspective, he raised several open questions on evolution, neutrality, and involution that required further research effort. Very recently, in 2024, Smarandache conducted research, from a soft sciences/philosophical viewpoint, on identifying and studying common parts in uncommon things and uncommon parts in common things emphasizing the complexity and interconnectedness of concepts within the context of neutrosophy. In this article, we …