Digital Commons Network^™

Sensory Home Programming Handouts, Taylor Ann Koopmeiners

Occupational Therapy Capstones

Background: Sensory processing is the way the brain and nervous system receive sensory information (Star Institute, 2023). When there are difficulties with processing sensory information, it is called Sensory Processing Disorder (SPD). Consequently, the inability to process sensory input results in affected motor and behavioral responses (Star Institute, 2023. This creates difficulty in participating in necessary tasks such as activities of daily living (ADLs), social participation, and school (Lane et al., 2019; Star Institute, 2023). Occupational therapists address these challenges by providing sensory activities in therapeutic sessions and as part of home programming (Gabriele, 2020). The goal of this scholarly …

An Occupational Therapy Program For First Responders Facing Trauma Fatigue And Work-Related Stressors Using Equine Facilitated Approaches, Kady Locke

Occupational Therapy Capstones

The proposed program is a mental health program, targeting meaningful daily occupations for the population of first responders facing trauma fatigue and antecedents of posttraumatic stress disorder symptoms related to stress from work. For individuals who serve as first responders, there is significant prevalence for trauma exposure, leading to trauma fatigue due to events encountered on the job. Mazur and Collins (2023) found that 80% of police and first responders experience traumatic events on the job and that 25% have experienced suicidal ideation due to impacts of trauma exposure. There is a lack of professional mental health services supporting this …

Breaking The Barrier To Leisure Engagement In Long-Term Care Facilities To Enhance Residents’ Health, Well-Being, And Quality Of Life, Callie M. Kleindl

Occupational Therapy Capstones

Title: Breaking the Barrier to Leisure Engagement in Long-Term Care Facilities to Enhance Residents’ Health, Well-being, and Quality of Life

Purpose: The purpose of this scholarly project was to promote leisure engagement for residents with dementia in long-term care (LTC) facilities to enhance their overall health, well-being, and quality of life (QOL).

Methodology: A thorough literature review supported the need for increased leisure engagement in LTC facilities for residents with dementia. Chronic conditions, such as dementia, impact a resident’s ability to engage in meaningful occupations which leads to occupational deprivation. In addition, a decline in leisure engagement has been found …

Addressing Health Care Needs Of Farmers In Rural Areas Through The Lens Of Occupational Therapy, Josie Lynn Huot

Occupational Therapy Capstones

Title: Addressing Health Care Needs of Farmers in Rural Areas through the Lens of Occupational Therapy

Background: Over three million farmers and farm laborers across the United States (U.S.) perform one of the most essential careers to support human life (Hildebrand et al., 2019; USDA, 2020). Farming is considered a highly dangerous job, putting farmers at risk for numerous health concerns, with a high prevalence of musculoskeletal injuries (Fethke et al., 2015; Hildebrand et al., 2019). Low back pain is a leading source of musculoskeletal pain, closely followed by neck pain, both of which are associated with the spine (Davis …

Making Strides: An Occupational Therapy Program Developing Work Readiness Skills In Adolescents With Aces, Using Equine And Barn Tasks., Lauren Alexis Fischer

Occupational Therapy Capstones

Background: The Center of Disease Control and Prevention (CDC, 2022) defines adverse childhood experiences (ACEs) as any traumatic event that occurs from birth to 18 years. ACEs can lead to various issues in the child's future, such as health problems, mental illness, substance abuse, and challenges with education and employment (CDC, 2022). Associated barriers that inhibit at-risk youth when transitioning into the workforce include lack of work skills, habits, knowledge about labor rights, realistic job opportunities, and how to pursue employment (Ivzori et al., 2020). Increasing support in their pre-vocational skills can increase their success in employment. Rhew et al. …

Activity Levels Across The Intensity Spectrum In Athletes: A Systematic Review Protocol, Jacob J. Capin, Jena Heck Street, Alissa V. Fial, Nicola D. Ridgers, Grant R. Tomkinson

Physical Therapy Faculty Research and Publications

Physical activity (PA) promotes better cardiometabolic health, physical function, brain health and longevity. In contrast, prolonged sedentary behaviour (SB) is a risk factor for many chronic diseases and poor health. Limited research has evaluated or synthesised how competitive sports participation influences PA across the lifespan. Some evidence suggests, ironically, that former competitive athletes may be insufficiently active and current athletes may be highly sedentary away from sport. This study describes the protocol for a systematic review and meta-analysis on activity levels across the intensity spectrum in athletes, addressing the primary research question: is sports participation significantly associated with PA and/or …

Methods That Support The Validation Of Agent-Based Models: An Overview And Discussion, Andrew Collins, Matthew Koehler, Christopher Lynch

Engineering Management & Systems Engineering Faculty Publications

Validation is the process of determining if a model adequately represents the system under study for the model’s intended purpose. Validation is a critical component in building the credibility of a simulation model with its end-users. Effectively conducting validation can be a daunting task for both novice and experienced simulation developers. Further compounding the difficult task of conducting validation is that there is no universally accepted approach for assessing a simulation. These challenges are particularly relevant to the paradigm of Agent-Based Modeling and Simulation (ABMS) because of the complexity found in these models’ mechanisms and in the real-world situations they …

Nanosecond Pulsed Electric Fields Increase Antibiotic Susceptibility In Methicillin-Resistant Staphylococcus Aureus, Alexandra E. Chittams-Miles, Areej Malik, Erin B. Purcell, Claudia Muratori

Bioelectrics Publications

Staphylococcus aureus is the leading cause of skin and soft-tissue infections (SSTIs). SSTIs caused by bacteria resistant to antimicrobials, such as methicillin-resistant S. aureus (MRSA), are increasing in incidence and have led to higher rates of hospitalization. In this study, we measured MRSA inactivation by nanosecond pulsed electric fields (nsPEF), a promising new cell ablation technology. Our results show that treatment with 120 pulses of 600 ns duration (28 kV/cm, 1 Hz), caused modest inactivation, indicating cellular damage. We anticipated that the perturbation created by nsPEF could increase antibiotic efficacy if nsPEF were applied as a co-treatment. To test this …

Intersectionality Matters In Food And Drug Law, Colleen Campbell

University of Colorado Law Review

Feminist scholars critique food and drug law as a site of gender bias and regulatory neglect. The historical exclusion of women from clinical trials by the FDA prioritized male bodies as the object of clinical research and therapies. Likewise, the FDA’s prior restriction on access to contraceptive birth control illustrates how patriarchal and paternalistic attitudes within the Agency can harm women’s reproductive health. However, there is little analysis of how race and gender intersect in this domain. This Article uses the regulation of skin-lightening cosmetics products to illustrate why and how intersectionality matters in food and drug law. While the …

Immigration Detention Abolition And The Violence Of Digital Cages, Sarah Sherman-Stokes

University of Colorado Law Review

The United States has a long history of pernicious immigration enforcement and surveillance. Today, in addition to more than 34,000 people held in immigration detention, Immigration and Customs Enforcement (ICE) shackles and surveils an astounding 376,000 people under its “Alternatives to Detention” (“ATD”) program. The number of people subjected to this surveillance has grown dramatically in the last two decades, from just about 1,700 in 2005. ICE’s rapidly expanding Alternatives to Detention program is a “digital cage,” consisting of GPS-outfitted ankle shackles and invasive phone and location tracking. Government officials and some immigrant advocates have characterized these digital cages as …

A First Amendment Failure: Surrendering To Science Misinformation For Bioengineered Foods, Casey J. Nelson

University of Colorado Law Review

Government-compelled commercial disclosures are not unfamiliar to consumers. Common labels include nutrition facts and ingredient information. The National Bioengineered Food Disclosure Standard, which took full force at the start of 2022, is of a different nature. The new law requires all manufacturers, all importers, and certain retailers of bioengineered foods to disclose on the food’s packaging that it has been produced with bioengineering technology. Even so, a large swath of the public is ignorant of “bioengineering’s” true meaning and bioengineering technology’s true quality. The politically charged and fact-lacking debate on bioengineered foods renders this standard an impermissible coercion of speech …

Front Matter

Lewis & Clark Law Review

Front Matter includes table of contents, masthead, and faculty for Lewis & Clark Law Review Volume 27, Number 4, 2024.

Renewing Study Into The Oldest Hatred: Introduction To The Law Vs. Antisemitism Symposium, David Schraub

Lewis & Clark Law Review

This short essay provides an introduction to the Lewis & Clark Law Review's "Law vs. Antisemitism" symposium, which grew out of the conference by the same name hosted at Lewis & Clark in the spring of 2023. In addition to overviewing the contributions to the symposium, the introduction provides some background on the relative paucity of legal scholarship that has addressed antisemitism, and the importance of including antisemitism in the otherwise robust legal academic conversation occurring around other forms of oppression and social discrimination.

Skin In The Game Revisited, Eric K. Ward

Lewis & Clark Law Review

No abstract provided.

Front Matter

Lewis & Clark Law Review

Front Matter includes Masthead, Table of Contents, and Lewis & Clark Law School Faculty for Lewis & Clark Law Review Volume 28, Issue 2.

Knowledge Commons Past, Present, And Future, Michael J. Madison

Lewis & Clark Law Review

The project now known as Governing Knowledge Commons, or GKC, was launched more than 15 years ago on the intuition that skepticism of intellectual property law and information exclusivity was grounded in anecdote and ideology rather than in empiricism. Structured, systematic, empirical research on mechanisms of knowledge sharing was needed. GKC aimed to help scholars produce it. Over multiple books, case studies, and other work, the scope of GKC has expanded considerably, from innovation to governance; from invention and creativity to data, privacy, and markets; and from social dilemmas focused on things to governance strategies directed to communities and collectives. …

A Systematic Qualitative Review: Improving Perinatal Health Outcomes In Communities Of Color, Amelia Abiem

Educational and Organizational Learning and Leadership Dissertations

This systematic qualitative review explored existing literature to understand the strategies community-based perinatal organizations employ to address perinatal morbidity and maternal mortality within communities of color and how cultural congruence healthcare workers may improve the perinatal health outcomes of these communities. This study explored 20 studies published within the United States between 2014 and 2024 focused on strategies employed by perinatal organizations serving marginalized communities and how leveraging cultural congruence may be instrumental in reducing perinatal healthcare inequalities within communities of color.

After a thorough review of these 20 studies, it was determined that key strategies exist for addressing perinatal …

Association Between Glucagon-Like Peptide-1 Receptor Agonists Use And Change In Alcohol Consumption: A Systematic Review, Mohsan Subhani, Ashwin Dhanda, James A. King, Fiona C. Warren, Siobhan Creanor, Melanie J. Davies, Sally Eldeghaidy, Stephen Bawden, Penny A. Gowland, Ramon Bataller, Justin Greenwood, Stephen Kaar, Neeraj Bhala, Guruprasad P. Aithal

Peninsula Medical School

Background: Despite the availability of various pharmacological and behavioural interventions, alcohol-related mortality is rising. This systematic review aimed to critically evaluate the existing literature on the association between glucagon-like peptide-1 receptor agonists use (GLP-1 RAs) and alcohol consumption. Methods: Electronic searches were conducted on Ovid Medline, EMBASE, PsycINFO, clintrials.gov, and ProQuest until the end of March 2024. An updated search was done on 7th of August 2024. The primary outcome was to explore the association between GLP-1 RAs use and change in alcohol consumption. Secondary outcomes included evaluating the impact of GLP-1 RAs on occurrences of alcohol-related events, healthcare utilisation, …

Identification Of Druggable Regulators Of Cell Secretion Via A Kinome-Wide Screen And High-Throughput Immunomagnetic Cell Sorting, Mahmoud Labib, Zongjie Wang, Yunhye Kim, Sichun Lin, Abdalla Abdrabou, Hanie Yousefi, Pei Ying Lo, Stéphane Angers, Edward H. Sargent, Shana O. Kelley

Peninsula Medical School

The identification of genetic regulators of cell secretions is challenging because it requires the sorting of a large number of cells according to their secretion patterns. Here we report the development and applicability of a high-throughput microfluidic method for the analysis of the secretion levels of large populations of immune cells. The method is linked with a kinome-wide loss-of-function CRISPR screen, immunomagnetically sorting the cells according to their secretion levels, and the sequencing of their genomes to identify key genetic modifiers of cell secretion. We used the method, which we validated against flow cytometry for cytokines secreted from primary mouse …

Preliminary Results Of A Study Using Dynamic Angiography In Predicting Progression Or Regression Of Moderate Severity Lesions, Thach Nguyen, Marco Zuin, Pham Tv Le, Vinh Sieu Lam, Hien Q. Nguyen, Hung V. Dang, Huyen K. Huynh, Duc Khiem Ngo, Thinh T. Nguyen, Imran Mihas

School of Medicine Publications

Background: Many patients with stable angina (SA) having moderate 50% lesions could deteriorate or stay stable for a long time. No present techniques nor test could accurately predict the progression to acute coronary syndrome (ACS) or stabilization of these moderate lesions. Based on the fluid dynamic methodology research, could turbulent flow further damage the plaque and rupture its cap? In contrast, could laminar flow delay the progression of the plaque and keep patients stable for a long period of time?

Methods: Patients with stable angina (SA) were admitted to the intermediate care unit and underwent coronary angiography. Patients were selected …

Peripartum Cardiomyopathy; Understanding And Improving Outcomes-A Systematic Review, Shakirat Ganiyu, Taiwo Akeem Lawal, Sarah Petrie

School of Medicine Publications

Background: Peripartum cardiomyopathy (PPCM) presents a significant global health challenge, contributing substantially to maternal morbidity and mortality worldwide. Despite ongoing research efforts, the multifaceted nature of PPCM, encompassing genetic, environmental, and clinical factors, necessitates a comprehensive understanding to improve patient outcomes effectively.

Aims: This systematic review aims to synthesise current knowledge on PPCM aetiology, risk factors, diagnosis, therapeutic interventions, and prognostic indicators, highlighting recent advancements and potential avenues for future research and clinical management. By addressing key aspects such as genetic predispositions, environmental influences, diagnostic strategies, therapeutic modalities, and global disparities, this review seeks to provide insights that can inform …

Protein Subunit Vaccines: Promising Frontiers Against Covid-19, Vivek P. Chavda, Eswara Naga Hanuma Kumar Ghali, Pankti C. Balar, Subhash Chauhan, Nikita Tiwari, Somanshi Shukla, Mansi Athalye, Vandana Bharat Patravale, Vasso Apostolopoulos, Murali Yallapu

School of Medicine Publications

The emergence of COVID-19 has posed an unprecedented global health crisis, challenging the healthcare systems worldwide. Amidst the rapid development of several vaccine formulations, protein subunit vaccines have emerged as a promising approach. This article provides an in-depth evaluation of the role of protein subunit vaccines in the management of COVID-19. Leveraging viral protein fragments, particularly the spike protein from SARS-CoV-2, these vaccines elicit a targeted immune response without the risk of inducing disease. Notably, the robust safety profile of protein subunit vaccines makes them a compelling candidate in the management of COVID-19. Various innovative approaches, including reverse vaccinology, virus …

Stress Biology: Complexity And Multifariousness In Health And Disease, Emily M. Sontag

Biological Sciences Faculty Research and Publications

Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. …

Synthesis And Evaluation Of 1,3-Disubstituted Imidazolidine-2,4,5-Triones As Inhibitors Of Pyruvate Carboxylase, Nicholas O. Schneider, Keandra Gilreath, Niel M. Henriksen, William A. Donaldson, Subhabrata Chaudhury, Martin St. Maurice

Biological Sciences Faculty Research and Publications

Substituted imidazolidinetriones (IZTs) have been identified as potent inhibitors of pyruvate carboxylase (PC) through an in silico screening approach. Alkyl 2-(2,4,5-trioxo-3-substituted imidazolidin-1-yl)acetates (6i–6r) are the most potent of the series, with IC50 values between 3 and 12 μM, and several IZTs demonstrate high passive permeability across an artificial membrane. IZTs are mixed-type inhibitors with respect to pyruvate and noncompetitive with respect to ATP. This class of inhibitors appears to be selective for PC. Inhibitors in the IZT series do not inhibit the metalloenzymes human carbonic anhydrase II and matrix metalloprotease-12, and they do not inhibit the related biotin-dependent enzyme, guanidine …

Ableist Microaggressions, Disability Characteristics, And Nondominant Identities, Melissa Deroche, Lee Za Ong, Jennifer M. Cook

College of Education Faculty Research and Publications

Microaggressions are commonplace overt and covert forms of discrimination that convey disparaging messages to individuals who hold marginalized identities, including people with disabilities (PWD). Although PWD are a prevalent nondominant identity group in the United States, little is known about the occurrence of ableist microaggressions in this culturally diverse community, including how ableist microaggressions are experienced based on disability characteristics and other nondominant identities. A sample consisting of 201 PWD completed an electronic survey that examined the occurrence of ableist microaggressions based on visibility of disability, type of disability, and nondominant sociocultural identities. We found that PWD have a moderate …

Dual Suppression Of Glossina Pallidipes Using Entomopathogenic Fungal-Based Biopesticides And Sterile Insect Technique, Fidelis L.O. Ombura, Adly M.M. Abd-Alla, Komivi S. Akutse, Steven Runo, Paul O. Mireji, Rosemary Bateta, Joseck E. Otiwi, Inusa J. Ajene, Fathiya M. Khamis

All Peer-Reviewed Publications

Tsetse flies and trypanosomosis significantly impact bovine production and human health in sub-Saharan Africa, exacerbating underdevelopment, malnutrition, and poverty. Despite various control strategies, long-term success has been limited. This study evaluates the combined use of entomopathogenic fungi (EPF) and the sterile insect technique (SIT) to combat tsetse flies. Eleven EPF isolates were tested against teneral males of Glossina pallidipes, focusing on mortality rates, radial growth, and impacts on fly fitness. Temperature effects on conidial growth, sporulation, and spore yield of SIT-compatible/tolerant strains were also assessed. The fungal isolates significantly influenced mortality rates in both unirradiated and irradiated (SIT-treated) males (p <  0.0001). Metarhizium anisopliae strains ICIPE 20, ICIPE 32, ICIPE 41, ICIPE 62, ICIPE 78, and Beauveria bassiana ICIPE 603 showed higher SIT compatibility/tolerance with LT50 values of 11–30 days, compared to other more virulent isolates with LT50 values of 4–9 days. Temperature significantly affected the radial growth of SIT-compatible EPF strains (p <  0.0001), with M. anisopliae ICIPE 78 exhibiting the fastest conidia growth at 25°C. Spore yield varied significantly across temperatures (15–40°C), and the thermal range for conidia germination of SIT-compatible strains was 8.1–45.4°C, with an optimal range of 26.7–31.1°C. Moreover, infected unirradiated females and irradiated males (donors) successfully transmitted conidia to untreated flies (receivers) without significant differences in survival rates (p = 0.6438) and no observed sex dimorphism. Our findings highlight the potential of combining EPF and SIT as a novel dual approach that could effectively and synergistically suppress tsetse fly populations.

Tissue-Specific Localization Of Tick-Borne Pathogens In Ticks Collected From Camels In Kenya: Insights Into Vector Competence, Rua Khogali, Armanda Bastos, Joel L. Bargul, Dennis Getange, James Kabii, Daniel Masiga, Jandouwe Villinger

All Peer-Reviewed Publications

Background: Tick-borne pathogen (TBP) surveillance studies often use whole-tick homogenates when inferring tick-pathogen associations. However, localized TBP infections within tick tissues (saliva, hemolymph, salivary glands, and midgut) can inform pathogen transmission mechanisms and are key to disentangling pathogen detection from vector competence. Methods: We screened 278 camel blood samples and 504 tick tissue samples derived from 126 camel ticks sampled in two Kenyan counties (Laikipia and Marsabit) for Anaplasma, Ehrlichia, Coxiella, Rickettsia, Theileria, and Babesia by PCR-HRM analysis. Results: Candidatus Anaplasma camelii infections were common in camels (91%), but absent in all samples from Rhipicephalus pulchellus, Amblyomma gemma, Hyalomma dromedarii, …

A Convolutional Neural Network With Image And Numerical Data To Improve Farming Of Edible Crickets As A Source Of Food—A Decision Support System, Henry Kyalo, Henri E.Z. Tonnang, James P. Egonyu, John Olukuru, Chrysantus M. Tanga, Kennedy Senagi

All Peer-Reviewed Publications

Crickets (Gryllus bimaculatus) produce sounds as a natural means to communicate and convey various behaviors and activities, including mating, feeding, aggression, distress, and more. These vocalizations are intricately linked to prevailing environmental conditions such as temperature and humidity. By accurately monitoring, identifying, and appropriately addressing these behaviors and activities, the farming and production of crickets can be enhanced. This research implemented a decision support system that leverages machine learning (ML) algorithms to decode and classify cricket songs, along with their associated key weather variables (temperature and humidity). Videos capturing cricket behavior and weather variables were recorded. From these videos, sound …

Ticks (Acari: Ixodidae) Infesting Cattle In Coastal Kenya Harbor A Diverse Array Of Tick-Borne Pathogens, Joseph Wang Ang A. Oundo, Shewit Kalayou, Quirine Ten Bosch, Jandouwe Villinger, Constantianus J.M. Koenraadt, Daniel Masiga

All Peer-Reviewed Publications

Ticks and the microbes they transmit have emerged in sub-Saharan Africa as a major threat to veterinary and public health. Although progress has been made in detecting and identifying tick-borne pathogens (TBPs) across vast agroecologies of Kenya, comprehensive information on tick species infesting cattle and their associated pathogens in coastal Kenya needs to be updated and expanded. Ticks infesting extensively grazed zebu cattle in 14 villages were sampled and identified based on morphology and molecular methods and tested for the presence of bacterial and protozoan TBPs using PCR with high-resolution melting analysis and gene sequencing. In total, 3,213 adult ticks …

Wto Law And Environmental Processes And Production Methods (Ppms): A Deconstruction, Irene Musselli

Indian Journal of International Economic Law

In principle, WTO members can adopt PPM measures to protect the environment, provided certain conditions are met to prevent the misuse of these measures for protectionist purposes. In practice, the judicial review of such measures in the WTO context is punctuated by practical difficulties, and is fraught with intractable uncertainty: most PPM regulations that were challenged passed on principle but failed on specific details related to the dispute at hand. This article aims to contribute to the PPM discussion by providing critical and deconstructive perspectives on trade law. It argues that the challenges in assessing WTO compliance of PPMs stem …