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2024

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Plasticity In Response To Temperature Magnitude And Variation---From Life History To Thermal Tolerance And Coloration, Austin Rex Hoffman Jan 2024

Plasticity In Response To Temperature Magnitude And Variation---From Life History To Thermal Tolerance And Coloration, Austin Rex Hoffman

University of the Pacific Theses and Dissertations

Warming associated with climate change has many direct and downstream effects on animals. For example, warmer developmental temperatures can improve heat tolerance and reduce insect melanization, which is related to coloration, thermoregulation, immunity, desiccation resistance, and potentially life-history traits, such as investment into reproduction and dispersal. Increased temperature variation is also a feature of climate change, and it may have a larger impact on animals than warming. However, I lack insight into the combined effects of temperature magnitude and variability on important traits of life history, thermal tolerance, and coloration. Thus, I integrated temperature variation into thermal performance using a …


Development Of Nano Formulations Of Lipophilic Platinum Complexes Against Lung Cancer, Zizhao Xu Jan 2024

Development Of Nano Formulations Of Lipophilic Platinum Complexes Against Lung Cancer, Zizhao Xu

University of the Pacific Theses and Dissertations

Lung cancer remains a leading cause of death worldwide and urges the development of more effective and safer treatment options. Conventional platinum-based drugs like cisplatin, while effective, are associated with significant systemic toxicity, particularly nephrotoxicity. Nano formulations, such as liposomal and micellar delivery systems, represent a promising approach to enhance the anticancer activity and reduce the toxicity of platinum complexes.

This study develops and evaluates novel miriplatin-loaded nano formulations for lung cancer therapy. We prepared and screened various liposomal and micellar formulations of miriplatin by either thin-film hydration or co-solvent evaporation, which identified a number of formulations with appropriate sizes …


Transgenerational Effects Of Stress On The Plasma Proteome Of A Marine Mammal, Emily Voelkner Jan 2024

Transgenerational Effects Of Stress On The Plasma Proteome Of A Marine Mammal, Emily Voelkner

University of the Pacific Theses and Dissertations

The physiological stress response enables animals to respond to changes in their environment, and is mediated by the hypothalamic-pituitary-adrenal (HPA) axis in mammals. Increased activation of the HPA axis by repeated stress during critical life stages like reproduction could affect fitness. Information about a stressor can be communicated to offspring via hormone signals prenatally, or postnatally via milk, and affect offspring development and stress reactivity. Experimentally activating the HPA axis by adrenocorticotropic hormone (ACTH) administration results in the synthesis of the major glucocorticoid hormone cortisol, which has well-studied far-reaching effects on growth, metabolism, and immunity. Beyond cortisol levels alone, biomarkers …


Lycosidae Abundance And Diversity Across Lawn And Leaf Litter Substrate, Sage O. Lockett, Dan Albrecht-Mallinger Jan 2024

Lycosidae Abundance And Diversity Across Lawn And Leaf Litter Substrate, Sage O. Lockett, Dan Albrecht-Mallinger

UROP Posters

Significant knowledge gaps exist in how land-cover impacts ground-hunting spider populations. To fill these gaps, this study investigates a common family of ground-hunting spiders, Lycosidae, to determine differences in their abundance and diversity in deciduous leaf litter and managed turfgrass (lawn). The study was conducted within a forested ecosystem at Virginia Commonwealth University's Rice Rivers Center in Charles City County, Virginia. I placed 10 belt transects (1m x 20m) on lawn substrate and 10 identical transects in deciduous forest leaf litter substrate. I performed repeated visual census via eyeshine and manual capture of up to three individuals per transect …


Neurodevelopmental Vulnerability To Gestational Ozone Exposure, Vishnupriya Alavala, Sarah E. Brent, Christopher G. Canal, Joseph Wang, Russell P. Hunter, Matthew J. Campen, Andrew K. Ottens Jan 2024

Neurodevelopmental Vulnerability To Gestational Ozone Exposure, Vishnupriya Alavala, Sarah E. Brent, Christopher G. Canal, Joseph Wang, Russell P. Hunter, Matthew J. Campen, Andrew K. Ottens

UROP Posters

Ambient air pollution accounts for about 4.2 million premature deaths annually per the World Health Organization. Ozone (O3) is a highly reactive air pollutant found in smog and is implicated in cellular damage leading to organ dysfunction. Ambient air pollution is associated with neurodevelopmental, behavioral, and cognitive disorders though ozone’s role is unknown. Studies here look at ozone exposure shortly after implantation vs. shortly before term to evaluate differences in neurodevelopmental susceptibility over time.

To inquire on the effects of ozone on the fetal brain, pregnant Sprague-Dawley rats were exposed once to 0.3 ppm of O3 or filtered air (FA) …


A Food-Exchange Model For Achieving The Recommended Dietary Intakes For Saturated Fat In Irish Children: Analysis From The Cross-Sectional National Children's Food Survey Ii, Aileen O'Connor, Maria Buffini, Anne P. Nugent, Laura Kehoe, Albert Flynn, Janette Walton, John Kearney, Breige Mcnulty Jan 2024

A Food-Exchange Model For Achieving The Recommended Dietary Intakes For Saturated Fat In Irish Children: Analysis From The Cross-Sectional National Children's Food Survey Ii, Aileen O'Connor, Maria Buffini, Anne P. Nugent, Laura Kehoe, Albert Flynn, Janette Walton, John Kearney, Breige Mcnulty

Articles

Objective: To identify the main foods determining saturated fatty acid (SFA) intakes and model the impact of food exchanges to improve compliance with dietary fat recommendations in Irish children. Design: Estimated food and nutrient intakes were obtained from a cross-sectional study, the National Children's Food Survey II. Participants were categorised into low, medium, and high SFA consumers, and the contribution of food categories to SFA intakes were compared. A food-exchange model was developed, whereby a selected range of high SFA foods were exchanged with lower SFA or unsaturated fat alternatives. Setting: Participants were randomly selected from primary schools throughout the …


Mud Acoustics, Charles W. Holland, Stan E. Dosso, Jason D. Chaytor Jan 2024

Mud Acoustics, Charles W. Holland, Stan E. Dosso, Jason D. Chaytor

Electrical and Computer Engineering Faculty Publications and Presentations

Imaging the ocean requires an understanding of how different seafloor sediments interact with sound waves.


Putting Lipstick On A Pig: Biogas, Methane Digesters, And The Greenwashing Playbook, Randall S. Abate Jan 2024

Putting Lipstick On A Pig: Biogas, Methane Digesters, And The Greenwashing Playbook, Randall S. Abate

GW Law Faculty Publications & Other Works

Industrial animal agriculture pitches biogas and methane digesters as solutions to the outsized methane footprint of concentrated animal feeding operations (CAFOs), yet these efforts merely seek to convey to the public that CAFOs’ operations are environmentally responsible. In reality, quite the opposite is true because biogas and methane digesters more deeply entrench these facilities into the status quo of unsustainable production and disposal methods at CAFOs. This article first describes industrial animal agriculture’s impacts on climate change, with a focus on methane emissions. It then addresses biogas and methane digesters as ineffective solutions to the methane emissions from CAFOs. Next, …


Debunking Criminal Restitution, Lula Hagos Jan 2024

Debunking Criminal Restitution, Lula Hagos

GW Law Faculty Publications & Other Works

Criminal restitution—the money paid by a defendant to a victim—is often overlooked amidst growing scholarly consensus about the adverse impact of criminal court fines and fees. Restitution receives less attention because it is perceived as a fair and unobjectionable sanction with legitimate goals, while fines and fees are now widely condemned as primarily serving as a funding source for local and state governments. Consequently, the animated and extensive discourse around financial punishment largely excludes criminal restitution.

Though criminal restitution may appear to have legitimate penological purposes, it serves to perpetually punish defendants who are poor—the vast majority of those in …


Bystanders To A Public Health Crisis: The Failures Of The U.S. Multi-Agency Regulatory Approach To Food Safety In The Face Of Persistent Organic Pollutants, Katya S. Cronin Jan 2024

Bystanders To A Public Health Crisis: The Failures Of The U.S. Multi-Agency Regulatory Approach To Food Safety In The Face Of Persistent Organic Pollutants, Katya S. Cronin

GW Law Faculty Publications & Other Works

Per- and polyfluoroalkyl substances (“PFAS”) are devastating our food systems and our health. Recent studies link even small exposure to PFAS to a host of adverse health outcomes, including cancer, autoimmune diseases, thyroid disease, liver damage, childhood obesity, infertility, and birth defects.

Food consumption is a primary route of PFAS exposure. PFAS are omnipresent at dangerous levels in our marine and agricultural environments, including in water, soil, fertilizers, compost, and air. From there, they can find their way into virtually every plant, fish, animal, and animal product, and ultimately (in the greatest concentration) into the consumer. In addition, PFAS-laden food …


Copyright And The Training Of Human Authors And Generative Machines, Robert Brauneis Jan 2024

Copyright And The Training Of Human Authors And Generative Machines, Robert Brauneis

GW Law Faculty Publications & Other Works

There are many limitations on copyright of which human authors can and do take advantage as they are learning. However, there is no blanket fair use immunity for use of copyrighted works to educate human authors, even though those authors typically do not go on to create substantially similar works. Human authors typically end up paying, directly or indirectly, for most of the copyrighted works from which they learn. Should it be different when human beings use copyrighted works to train generative AI models? This article concludes that it should not, in spite of two prominent arguments to the contrary. …


Plenary Power: Teaching The Immigration Law Of The Territories, Cori Alonso-Yoder Jan 2024

Plenary Power: Teaching The Immigration Law Of The Territories, Cori Alonso-Yoder

GW Law Faculty Publications & Other Works

Immigration law dominates national headlines and policy debates while immigrant communities struggle to secure legal representation. Law students are increasingly aware of these issues, often bringing lived experiences of the immigration system into the classroom. As immigration law professors seek to engage these students with doctrinal and clinical coursework, they often struggle to incorporate policy priorities and executive actions that shift with the political winds. In this tumult, many immigration law professors fail to realize that there is an entire body of U.S. immigration law they are not teaching-the immigration law of the U.S. territories. Indeed, many professors may not …


Are "Book Bans" Unconstitutional? Reflections On Public School Libraries And The Limits Of Law, Catherine J. Ross Jan 2024

Are "Book Bans" Unconstitutional? Reflections On Public School Libraries And The Limits Of Law, Catherine J. Ross

GW Law Faculty Publications & Other Works

Since 2021, the number of demands that public school libraries remove materials from their shelves based on content has accelerated almost too quickly to track. Book removal incidents are more prevalent today than at any time since data became available, doubling between 2021 and 2022. Such “book bans” (as opponents characterize them) or “targeted book removals” (as the courts call them) arise in the context of intense political and cultural divisions and, in turn, exacerbate those conflicts. Indeed, national organizations as well as politicians at every level have played a role in the contemporary attack on library materials, which disproportionately …


Brave, El Musical (2024), Esther García Serrano Jan 2024

Brave, El Musical (2024), Esther García Serrano

Grado en Diseño de Moda

Como trasladar el vestuario de una animación a la realidad, sin perder la esencia de cada personaje y el mundo en el que se basa la película, es el principal problema que se abordará en esta investigación. Este estudio tiene como objetivo hacer una propuesta completa centrándose en el diseño de vestuario para la creación de un musical además de recrear la estética de la película. Se analizó la indumentaria escocesa y medieval con documentos escritos de expertos en historia del arte y se analizaron datos conformando el éxito de este tipo de proyectos en Madrid. La investigación proporciona información …


Teaching Dobbs To Disrupt U.S. Hegemony And Build Feminist Solidarities, Derek P. Siegel Jan 2024

Teaching Dobbs To Disrupt U.S. Hegemony And Build Feminist Solidarities, Derek P. Siegel

Sociology & Criminal Justice Faculty Publications

The Dobbs decision has created both opportunities and challenges in the classroom. On one hand, Dobbs animated student interest, increasing awareness of reproduction. On the other hand, media coverage of Dobbs primed students—particularly those who had not been exposed to reproductive justice—to think about abortion access in isolation from other topics and from an exclusively U.S. perspective. In this article, I discuss my experience teaching Politics of Reproduction in Fall 2022. Among other goals, I wanted to expose students to La Marea Verde, or the “Green Wave,” of countries expanding abortion access in Latin America. By teaching Latin American abortion …


Preclinical Study And Parallel Phase Ii Trial Evaluating Antisense Stat3 Oligonucleotide And Checkpoint Blockade For Advanced Pancreatic, Non-Small Cell Lung Cancer And Mismatch Repair-Deficient Colorectal Cancer, Chad Tang, Genevieve P Hartley, Coline Couillault, Ying Yuan, Heather Lin, Courtney Nicholas, Anupallavi Srinivasamani, James Dai, Ecaterina E Ileana Dumbrava, Siqing Fu, Daniel D Karp, Aung Naing, Sarina A Piha-Paul, Jordi Rodon Ahnert, Shubham Pant, Vivek Subbiah, Timonthy A Yap, Apostolia M Tsimberidou, Paola Guerrero, Sarah Dhebat, Theresa Proia, Michael A Curran, David S Hong Jan 2024

Preclinical Study And Parallel Phase Ii Trial Evaluating Antisense Stat3 Oligonucleotide And Checkpoint Blockade For Advanced Pancreatic, Non-Small Cell Lung Cancer And Mismatch Repair-Deficient Colorectal Cancer, Chad Tang, Genevieve P Hartley, Coline Couillault, Ying Yuan, Heather Lin, Courtney Nicholas, Anupallavi Srinivasamani, James Dai, Ecaterina E Ileana Dumbrava, Siqing Fu, Daniel D Karp, Aung Naing, Sarina A Piha-Paul, Jordi Rodon Ahnert, Shubham Pant, Vivek Subbiah, Timonthy A Yap, Apostolia M Tsimberidou, Paola Guerrero, Sarah Dhebat, Theresa Proia, Michael A Curran, David S Hong

Faculty, Staff and Student Publications

Objective: To evaluate signal transducer and activator of transcription 3 (STAT3) inhibition we conducted a co-clinical trial testing danvatirsen, a STAT3 antisense oligonucleotide (ASO) and checkpoint inhibition in conjunction with preclinical experiments.

Methods and analysis: Orthotopically implanted pancreatic cancer (pancreatic adenocarcinoma (PDAC)) was treated with STAT3 ASO with immune checkpoint inhibition. Tumour infiltrating immune cell populations were characterised via flow cytometry. In vitro experiments evaluated STAT3 inhibition in pancreatic stellate cells (PSCs) and myeloid-derived suppressor cells (MDSCs).A phase II trial employing a Simon II stage design tested the clinical efficacy of danvatirsen and durvalumab in non-small cell lung cancer (NSCLC), …


Crosstalk Between Breast Cancer-Derived Micrornas And Brain Microenvironmental Cells In Breast Cancer Brain Metastasis, Munazza S Khan, Grace L Wong, Chuling Zhuang, Mariana K Najjar, Hui-Wen Lo Jan 2024

Crosstalk Between Breast Cancer-Derived Micrornas And Brain Microenvironmental Cells In Breast Cancer Brain Metastasis, Munazza S Khan, Grace L Wong, Chuling Zhuang, Mariana K Najjar, Hui-Wen Lo

Faculty, Staff and Student Publications

Breast cancer is the most frequent malignancy in women, constituting 15.2% of all new cancers diagnosed in the United States. Distant breast cancer metastasis accounts for the majority of breast cancer-related deaths; brain metastasis is the third most common site for metastatic breast cancer but is associated with worst prognosis of approximately eight months of survival. Current treatment options for breast cancer brain metastasis (BCBM) are limited and ineffective. To help identify new and effective therapies for BCBM, it is important to investigate the mechanisms by which breast cancer cells metastasize to the brain and thrive in the brain microenvironment. …


Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study Of Before-After Data, Rossella Cannarella, Rupin Shah, Taha Abo-Almagd Abdel-Meguid Hamoda, Florence Boitrelle, Ramadan Saleh, Murat Gul, Amarnath Rambhatla, Parviz Kavoussi, Tuncay Toprak, Ahmed M Harraz, Edmund Ko, Gökhan Çeker, Damayanthi Durairajanayagam, Noora Alkahidi, Shinnosuke Kuroda, Andrea Crafa, Ralf Henkel, Gianmaria Salvio, Berk Hazir, Mahsa Darbandi, Marion Bendayan, Sara Darbandi, Marco Falcone, Nicolas Garrido, Raghavender Kosgi, Raneen Sawaid Kaiyal, Keshab Karna, Nguyen Ho Vinh Phuoc, Ponco Birowo, Giovanni M Colpi, Jean De La Rosette, Germar-Michael Pinggera, Quang Nguyen, Armand Zini, Wael Zohdy, Rajender Singh, Pallavi Saini, Sidney Glina, Haocheng Lin, Taymour Mostafa, Cesar Rojas-Cruz, Mohamed Arafa, Aldo E Calogero, Fotios Dimitriadis, Priyank Kothari, Vilvapathy Senguttuvan Karthikeyan, Keisuke Okada, Koji Chiba, Ates Kadıoglu, Baris Altay, Tahsin Turunc, Birute Zilaitiene, Fatih Gokalp, Aram Adamyan, Darren Katz, Eric Chung, Tiago Cesar Mierzwa, Daniel Suslik Zylbersztejn, Gustavo Marquesine Paul, Nikolaos Sofikitis, Ioannis Sokolakis, Vineet Malhotra, Sakti Ronggowardhana Brodjonegoro, Ricky Adriansjah, Akira Tsujimura, Toshiyasu Amano, Giancarlo Balercia, Imad Ziouziou, Isaac Ardianson Deswanto, Marlon Martinez, Hyun Jun Park, Mustafa Emre Bakırcıoglu, Erman Ceyhan, Kaan Aydos, Jonathan Ramsay, Suks Minhas, Manaf Al Hashimi, Ramy Abou Ghayda, Nicholas Tadros, Puneet Sindhwani, Christopher C K Ho, Rinaldo Indra Rachman, Marcelo Rodriguez Pena, Ahmad Motawi, Arun Karthik Ponnusamy, Satish Dipankar, Azwar Amir, Saleh Binsaleh, Ege Can Serefoglu, Ravi Banthia, Kareim Khalafalla, Ari Basukarno, Nguyen Hoai Bac, Karun Singla, Rafael F Ambar, Konstantinos Makarounis, Shivam Priyadarshi, Gede Wirya Kusuma Duarsa, Widi Atmoko, Sunil Jindal, Eko Arianto, Hamed Akhavizadegan, Haitham El Bardisi, Ohad Shoshany, Gian Maria Busetto, Mohamad Moussa, Mounir Jamali, Mohamed S Al-Marhoon, Mikhail Ruzaev, Hasan M A Farsi, Shingai Mutambirwa, Dong Sup Lee, Deniz Kulaksiz, Yu-Sheng Cheng, Abderrazak Bouzouita, Selcuk Sarikaya, Hussein Kandil, Georgios Tsampoukas, Ala'a Farkouh, Kasonde Bowa, Missy Savira, Nasser Mogharabian, Tan V Le, Maruto Harjanggi, Dang Tuan Anh, Tran Quang Tien Long, Mohammad Ayodhia Soebadi, Lukman Hakim, Marko Tanic, Umut Cagin Ari, Firuza R Parikh, Gokhan Calik, Vinod Kv, Gyem Dorji, Andri Rezano, Osvaldo Rajmil, Dung Mai Ba Tien, Yiming Yuan, Juan Francisco Lizarraga-Salas, Balantine Eze, Kay Seong Ngoo, Joe Lee, Umut Arslan, Ashok Agarwal, Global Andrology Forum Jan 2024

Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study Of Before-After Data, Rossella Cannarella, Rupin Shah, Taha Abo-Almagd Abdel-Meguid Hamoda, Florence Boitrelle, Ramadan Saleh, Murat Gul, Amarnath Rambhatla, Parviz Kavoussi, Tuncay Toprak, Ahmed M Harraz, Edmund Ko, Gökhan Çeker, Damayanthi Durairajanayagam, Noora Alkahidi, Shinnosuke Kuroda, Andrea Crafa, Ralf Henkel, Gianmaria Salvio, Berk Hazir, Mahsa Darbandi, Marion Bendayan, Sara Darbandi, Marco Falcone, Nicolas Garrido, Raghavender Kosgi, Raneen Sawaid Kaiyal, Keshab Karna, Nguyen Ho Vinh Phuoc, Ponco Birowo, Giovanni M Colpi, Jean De La Rosette, Germar-Michael Pinggera, Quang Nguyen, Armand Zini, Wael Zohdy, Rajender Singh, Pallavi Saini, Sidney Glina, Haocheng Lin, Taymour Mostafa, Cesar Rojas-Cruz, Mohamed Arafa, Aldo E Calogero, Fotios Dimitriadis, Priyank Kothari, Vilvapathy Senguttuvan Karthikeyan, Keisuke Okada, Koji Chiba, Ates Kadıoglu, Baris Altay, Tahsin Turunc, Birute Zilaitiene, Fatih Gokalp, Aram Adamyan, Darren Katz, Eric Chung, Tiago Cesar Mierzwa, Daniel Suslik Zylbersztejn, Gustavo Marquesine Paul, Nikolaos Sofikitis, Ioannis Sokolakis, Vineet Malhotra, Sakti Ronggowardhana Brodjonegoro, Ricky Adriansjah, Akira Tsujimura, Toshiyasu Amano, Giancarlo Balercia, Imad Ziouziou, Isaac Ardianson Deswanto, Marlon Martinez, Hyun Jun Park, Mustafa Emre Bakırcıoglu, Erman Ceyhan, Kaan Aydos, Jonathan Ramsay, Suks Minhas, Manaf Al Hashimi, Ramy Abou Ghayda, Nicholas Tadros, Puneet Sindhwani, Christopher C K Ho, Rinaldo Indra Rachman, Marcelo Rodriguez Pena, Ahmad Motawi, Arun Karthik Ponnusamy, Satish Dipankar, Azwar Amir, Saleh Binsaleh, Ege Can Serefoglu, Ravi Banthia, Kareim Khalafalla, Ari Basukarno, Nguyen Hoai Bac, Karun Singla, Rafael F Ambar, Konstantinos Makarounis, Shivam Priyadarshi, Gede Wirya Kusuma Duarsa, Widi Atmoko, Sunil Jindal, Eko Arianto, Hamed Akhavizadegan, Haitham El Bardisi, Ohad Shoshany, Gian Maria Busetto, Mohamad Moussa, Mounir Jamali, Mohamed S Al-Marhoon, Mikhail Ruzaev, Hasan M A Farsi, Shingai Mutambirwa, Dong Sup Lee, Deniz Kulaksiz, Yu-Sheng Cheng, Abderrazak Bouzouita, Selcuk Sarikaya, Hussein Kandil, Georgios Tsampoukas, Ala'a Farkouh, Kasonde Bowa, Missy Savira, Nasser Mogharabian, Tan V Le, Maruto Harjanggi, Dang Tuan Anh, Tran Quang Tien Long, Mohammad Ayodhia Soebadi, Lukman Hakim, Marko Tanic, Umut Cagin Ari, Firuza R Parikh, Gokhan Calik, Vinod Kv, Gyem Dorji, Andri Rezano, Osvaldo Rajmil, Dung Mai Ba Tien, Yiming Yuan, Juan Francisco Lizarraga-Salas, Balantine Eze, Kay Seong Ngoo, Joe Lee, Umut Arslan, Ashok Agarwal, Global Andrology Forum

Faculty, Staff and Student Publications

Purpose: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles.

Materials and methods: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: …


Technical Aspects And Clinical Limitations Of Sperm Dna Fragmentation Testing In Male Infertility: A Global Survey, Current Guidelines, And Expert Recommendations, Ashok Agarwal, Ala'a Farkouh, Ramadan Saleh, Taha Abo-Almagd Abdel-Meguid Hamoda, Gianmaria Salvio, Florence Boitrelle, Ahmed M Harraz, Ramy Abou Ghayda, Parviz Kavoussi, Murat Gül, Tuncay Toprak, Giorgio Ivan Russo, Damayanthi Durairajanayagam, Amarnath Rambhatla, Ponco Birowo, Rossella Cannarella, Nguyen Ho Vinh Phuoc, Armand Zini, Mohamed Arafa, Christine Wyns, Kelton Tremellen, Selçuk Sarıkaya, Sheena Lewis, Donald P Evenson, Edmund Ko, Aldo E Calogero, Fahmi Bahar, Marlon Martínez, Rafael F Ambar, Giovanni M Colpi, Mustafa Emre Bakircioglu, Ralf Henkel, Hussein Kandil, Ege Can Serefoglu, Abdullah Alfakhri, Akira Tsujimura, Alireza Kheradmand, Angelo Marino, Aram Adamyan, Birute Zilaitiene, Cevahir Ozer, Edoardo Pescatori, Paraskevi Vogiatzi, Gian Maria Busetto, Giancarlo Balercia, Haitham Elbardisi, Hamed Akhavizadegan, Hesamoddin Sajadi, Hisanori Taniguchi, Hyun Jun Park, Israel Maldonado Rosas, Mohamed Al-Marhoon, Mohammad Ali Sadighi Gilani, Naif Alhathal, Nguyen Quang, Germar-Michael Pinggera, Priyank Kothari, Sava Micic, Sheryl Homa, Tran Quang Tien Long, Wael Zohdy, Widi Atmoko, Wael Ibrahim, Marjan Sabbaghian, Saad Mohammed Abumelha, Eric Chung, Muhammet Rasit Ugur, Mehmet Serkan Ozkent, Osama Selim, Mahsa Darbandi, Shinichiro Fukuhara, Mounir Jamali, Jean De La Rosette, Shinnosuke Kuroda, Ryan P Smith, Aykut Baser, Arif Kalkanli, Nicholas N Tadros, Kaan Aydos, Tiago Cesar Mierzwa, Kareim Khalafalla, Vineet Malhotra, Mohamad Moussa, Federica Finocchi, Rinaldo Indra Rachman, Carlo Giulioni, Tomer Avidor-Reiss, Oguzhan Kahraman, Gökhan Çeker, Cătălina Zenoaga-Barbăroșie, Trenton L Barrett, Mehmet Yilmaz, Ates Kadioglu, Sunil Jindal, Huda Omran, Kadir Bocu, Vilvapathy Senguttuvan Karthikeyan, Giorgio Franco, Jesús Fernando Solorzano, Ranjit B Vishwakarma, Eko Arianto, Nicolas Garrido, Divyanu Jain, Nazim Gherabi, Ioannis Sokolakis, Ayad Palani, Gokhan Calik, Deniz Kulaksiz, Vaida Simanaviciene, Mara Simopoulou, Nur Dokuzeylül Güngör, Gideon Blecher, Marco Falcone, Davor Jezek, Mirko Preto, Edouard Amar, Tan V Le, Sun Tae Ahn, Andri Rezano, Keerti Singh, Lucia Rocco, Missy Savira, Osvaldo Rajmil, Sara Darbandi, Emrullah Sogutdelen, Luca Boeri, Guadalupe Hernández, Lukman Hakim, Yoshiharu Morimoto, Andrian Japari, Nikolaos Sofikitis, Baris Altay, Asli Metin Mahmutoglu, Manaf Al Hashimi, Imad Ziouziou, Christina Anagnostopoulou, Haocheng Lin, Rupin Shah Jan 2024

Technical Aspects And Clinical Limitations Of Sperm Dna Fragmentation Testing In Male Infertility: A Global Survey, Current Guidelines, And Expert Recommendations, Ashok Agarwal, Ala'a Farkouh, Ramadan Saleh, Taha Abo-Almagd Abdel-Meguid Hamoda, Gianmaria Salvio, Florence Boitrelle, Ahmed M Harraz, Ramy Abou Ghayda, Parviz Kavoussi, Murat Gül, Tuncay Toprak, Giorgio Ivan Russo, Damayanthi Durairajanayagam, Amarnath Rambhatla, Ponco Birowo, Rossella Cannarella, Nguyen Ho Vinh Phuoc, Armand Zini, Mohamed Arafa, Christine Wyns, Kelton Tremellen, Selçuk Sarıkaya, Sheena Lewis, Donald P Evenson, Edmund Ko, Aldo E Calogero, Fahmi Bahar, Marlon Martínez, Rafael F Ambar, Giovanni M Colpi, Mustafa Emre Bakircioglu, Ralf Henkel, Hussein Kandil, Ege Can Serefoglu, Abdullah Alfakhri, Akira Tsujimura, Alireza Kheradmand, Angelo Marino, Aram Adamyan, Birute Zilaitiene, Cevahir Ozer, Edoardo Pescatori, Paraskevi Vogiatzi, Gian Maria Busetto, Giancarlo Balercia, Haitham Elbardisi, Hamed Akhavizadegan, Hesamoddin Sajadi, Hisanori Taniguchi, Hyun Jun Park, Israel Maldonado Rosas, Mohamed Al-Marhoon, Mohammad Ali Sadighi Gilani, Naif Alhathal, Nguyen Quang, Germar-Michael Pinggera, Priyank Kothari, Sava Micic, Sheryl Homa, Tran Quang Tien Long, Wael Zohdy, Widi Atmoko, Wael Ibrahim, Marjan Sabbaghian, Saad Mohammed Abumelha, Eric Chung, Muhammet Rasit Ugur, Mehmet Serkan Ozkent, Osama Selim, Mahsa Darbandi, Shinichiro Fukuhara, Mounir Jamali, Jean De La Rosette, Shinnosuke Kuroda, Ryan P Smith, Aykut Baser, Arif Kalkanli, Nicholas N Tadros, Kaan Aydos, Tiago Cesar Mierzwa, Kareim Khalafalla, Vineet Malhotra, Mohamad Moussa, Federica Finocchi, Rinaldo Indra Rachman, Carlo Giulioni, Tomer Avidor-Reiss, Oguzhan Kahraman, Gökhan Çeker, Cătălina Zenoaga-Barbăroșie, Trenton L Barrett, Mehmet Yilmaz, Ates Kadioglu, Sunil Jindal, Huda Omran, Kadir Bocu, Vilvapathy Senguttuvan Karthikeyan, Giorgio Franco, Jesús Fernando Solorzano, Ranjit B Vishwakarma, Eko Arianto, Nicolas Garrido, Divyanu Jain, Nazim Gherabi, Ioannis Sokolakis, Ayad Palani, Gokhan Calik, Deniz Kulaksiz, Vaida Simanaviciene, Mara Simopoulou, Nur Dokuzeylül Güngör, Gideon Blecher, Marco Falcone, Davor Jezek, Mirko Preto, Edouard Amar, Tan V Le, Sun Tae Ahn, Andri Rezano, Keerti Singh, Lucia Rocco, Missy Savira, Osvaldo Rajmil, Sara Darbandi, Emrullah Sogutdelen, Luca Boeri, Guadalupe Hernández, Lukman Hakim, Yoshiharu Morimoto, Andrian Japari, Nikolaos Sofikitis, Baris Altay, Asli Metin Mahmutoglu, Manaf Al Hashimi, Imad Ziouziou, Christina Anagnostopoulou, Haocheng Lin, Rupin Shah

Faculty, Staff and Student Publications

Purpose: Sperm DNA fragmentation (SDF) is a functional sperm abnormality that can impact reproductive potential, for which four assays have been described in the recently published sixth edition of the WHO laboratory manual for the examination and processing of human semen. The purpose of this study was to examine the global practices related to the use of SDF assays and investigate the barriers and limitations that clinicians face in incorporating these tests into their practice.

Materials and methods: Clinicians managing male infertility were invited to complete an online survey on practices related to SDF diagnostic and treatment approaches. Their responses …


Configuring Thermal Ablation Volumes For Treatment Of Distinct Tumor Shapes: A Repeatability Study Using A Robotic Approach, Milica Bulatović, Jan Hermann, Pascale Tinguely, Iwan Paolucci, Stefan Weber Jan 2024

Configuring Thermal Ablation Volumes For Treatment Of Distinct Tumor Shapes: A Repeatability Study Using A Robotic Approach, Milica Bulatović, Jan Hermann, Pascale Tinguely, Iwan Paolucci, Stefan Weber

Faculty, Staff and Student Publications

Objectives: In the current clinical practice of thermal ablation treatment for liver tumors, achieving consistent and effective clinical outcomes across tumors of varying shapes, sizes and locations remains challenging. The aim of this study was to evaluate the repeatability of a novel robotic approach for configurable ablation of distinct tumor shapes and compare it to the standard ablation technique for creating ellipsoidal ablation volumes.

Materials and methods: The repeatability was evaluated in terms of width variability in created ablation volumes. Using a robotic navigation platform, custom ablation profiles configured with power, time, and distance parameters were designed to create four …


Transcriptomics Analysis Reveals Potential Mechanisms Underlying Mitochondrial Dysfunction And T Cell Exhaustion In Astronauts’ Blood Cells In Space, Maria Moreno-Villanueva, Luis E Jimenez-Chavez, Stephanie Krieger, Liang-Hao Ding, Ye Zhang, Adriana Babiak-Vazquez, Mark Berres, Sandra Splinter, Kristen E Pauken, Brian C Schaefer, Brian E Crucian, Honglu Wu Jan 2024

Transcriptomics Analysis Reveals Potential Mechanisms Underlying Mitochondrial Dysfunction And T Cell Exhaustion In Astronauts’ Blood Cells In Space, Maria Moreno-Villanueva, Luis E Jimenez-Chavez, Stephanie Krieger, Liang-Hao Ding, Ye Zhang, Adriana Babiak-Vazquez, Mark Berres, Sandra Splinter, Kristen E Pauken, Brian C Schaefer, Brian E Crucian, Honglu Wu

Faculty, Staff and Student Publications

Introduction: The impact of spaceflight on the immune system and mitochondria has been investigated for decades. However, the molecular mechanisms underlying spaceflight-induced immune dysregulations are still unclear.

Methods: In this study, blood from eleven crewmembers was collected before and during International Space Station (ISS) missions. Transcriptomic analysis was performed in isolated peripheral blood mononuclear cells (PBMCs) using RNA-sequencing. Differentially expresses genes (DEG) in space were determined by comparing of the inflight to the preflight samples. Pathways and statistical analyses of these DEG were performed using the Ingenuity Pathway Analysis (IPA) tool.

Results: In comparison to pre-flight, a total of 2030 …


Integrating Christian Beliefs And Scientific Psychology: Honoring John Carter, Rodger K. Bufford Jan 2024

Integrating Christian Beliefs And Scientific Psychology: Honoring John Carter, Rodger K. Bufford

Faculty Publications - Doctor of Psychology (PsyD) Program

John Carter had a profound role in shaping the thinking of generations of students and scholars in our understanding of the relationship of Christian beliefs and modern psychol- ogy. That Carter and Narramore’s (1979) volume remains in print and in use after more than four decades is a testimony to that influence. Here, I briefly explore the ways of knowing in general and elaborate on scientific knowing as a unique and powerful approach to appre- hending what our senses and instruments reveal. Scientific knowing is premised on several essential assumptions, employs a time-tested array of strategies to systematically gath- er …


Exposure To Metal Accumulation In Chicken Giblets And Human Health Risk In Lokoja, Nigeria, Jude Ehwevwerhere Emurotu, Lami Habib, Ephraim Musa Dallatu, Adamu Shuaibu Onakpa, Aloysius Akaangee Pam Jan 2024

Exposure To Metal Accumulation In Chicken Giblets And Human Health Risk In Lokoja, Nigeria, Jude Ehwevwerhere Emurotu, Lami Habib, Ephraim Musa Dallatu, Adamu Shuaibu Onakpa, Aloysius Akaangee Pam

Applied Environmental Research

When consumed, the toxic heavy metals in chicken giblets pose a grave risk to humans. An inductively coupled plasma optical emission spectrometer (ICP-OES) was used to measure the concentrations of metals (Al, Cd, Co, Cr, Ni, Mn, and Pb) in the liver, gizzard, and kidney of chickens from the Lokoja poultry market. Except for lead, which slightly exceeded the FAO/WHO limit of 0.1 mg kg-1, the metal concentrations found were all within the threshold limit. The estimated daily intake (EDI), hazard quotient (HQ), hazard index (HI), and cancer risk (CR) were used to assess the risks that humans would face …


Minimization The Chemical Oxygen Demand (Cod) Content In Tannery Wastewater Using Activated Carbon From Spent Tea Leaves, Kanish Fatama, Nasifa Akter, Badhan Saha, Nur -E- Alam Md., Shimul Chakma Jan 2024

Minimization The Chemical Oxygen Demand (Cod) Content In Tannery Wastewater Using Activated Carbon From Spent Tea Leaves, Kanish Fatama, Nasifa Akter, Badhan Saha, Nur -E- Alam Md., Shimul Chakma

Applied Environmental Research

Water pollution from tannery wastewater is a serious environmental issue. This study aimed to investigate the potential of spent tea leaves as activated carbon (AC) to minimize chemical oxygen demand (COD) of tannery effluent. To determine the best conditions for minimizing COD, a batch adsorption process was conducted, involving various factors such as different adsorbent dosages (ranging from 1 to 11 gm L-1), contact time (30 to150 min), and pH values (ranging from 3 to 11). The characterization was done by Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM). The outcomes of this study demonstrated that using 1.5 M …


Outlooks And Challenges For Urban Green Space Development: A Review Case Study In Thailand, Kanawat Paoin, Chanathip Pharino Jan 2024

Outlooks And Challenges For Urban Green Space Development: A Review Case Study In Thailand, Kanawat Paoin, Chanathip Pharino

Applied Environmental Research

Even though prior studies have provided ample proof of the benefits of urban green space, Thailand's development and exploitation of urban green space remain insufficiently efficient. To assess the prospects for urban green space development in Thailand, our review study highlighted gaps and challenges related to these areas. This review study discussed the rationale for urban green space, its definitions, as well as its benefits and co-benefits (i.e., economic, social, health, and environmental). The review research additionally discussed Thailand's current urban green space issues, associated challenges (such as difficulties valuing and using urban green space, budgetary limitations, low priority for …


Global Perspectives On Healthcare Waste Management And Bibliographic Mapping During The Crises Of Covid-19, Vasudeo Zambare, Bhushan Bhusare, Lew Christopher, Mohanadoss Ponraj, Nabin Narayan Munankarmi, Mohd Fadhil Md. Din Jan 2024

Global Perspectives On Healthcare Waste Management And Bibliographic Mapping During The Crises Of Covid-19, Vasudeo Zambare, Bhushan Bhusare, Lew Christopher, Mohanadoss Ponraj, Nabin Narayan Munankarmi, Mohd Fadhil Md. Din

Applied Environmental Research

The lack of proper waste management of health care facilities can have a significant negative health impact on the global population. This study provides a critical view on the current state of the existing healthcare waste management practices used in healthcare facilities around the world during the Coronavirus disease 2019 (COVID-19) pandemic outbreak. The increasing amount of COVID-related healthcare waste was analyzed and classified to provide justification for the urgent need to develop waste management standards that ensure safe containment and diversion of hazardous and non-hazardous wastes through recycling, reuse and repurposing. The waste handling, treatment, and disposal management of …


Assessment Of Total Petroleum Carbon And Heavy Metals Of Some Selected Plants Grown In Crude Oil Polluted Soils Using Gc-Fid, Pius O. Adah, Ndem E. Edu, Reagan B. Agbor, Henry B. Kogbara Jan 2024

Assessment Of Total Petroleum Carbon And Heavy Metals Of Some Selected Plants Grown In Crude Oil Polluted Soils Using Gc-Fid, Pius O. Adah, Ndem E. Edu, Reagan B. Agbor, Henry B. Kogbara

Applied Environmental Research

This study was focused on assessing the phytoremediation potentials of some selected plant species on crude oil contaminated soils. Five plant species were cultivated in soils polluted with crude oil at 10, 50, 100, 150 and 200 mg kg-1. The results revealed that there were significant reduction in THC contents of soil ameliorated with the various plants species compared to the control group increases with increasing concentration of crude oil pollutant in soil. THC was 62.24 mg kg-1, 1,120 mg kg-1, 208.67 mg kg-1, 257.87 mg kg-1 and 2,762.79 mg kg-1 for R. simplex, P. balfouriana, K. pinnata …


Food Waste From Catering Services In Thai Hotels: A Composition Analysis And Practical Guidelines For Effective Utilization, Patranit Srijuntrapun, Patinya Sukwong Jan 2024

Food Waste From Catering Services In Thai Hotels: A Composition Analysis And Practical Guidelines For Effective Utilization, Patranit Srijuntrapun, Patinya Sukwong

Applied Environmental Research

Food waste from the hotel sector is a significant contributor to the overall volume of food waste, particularly in restaurants and food services through various processes. However, precise data on food waste generated by the hotel industry is lacking. This study aims to quantify and characterize the food waste generated during the preparation and serving processes in hotel catering, with the goal of finding efficient solutions to reduce food waste that are appropriate for the hotel and catering sectors. The study presents novel findings that among the different types of catering, dinner-style buffets (DB) generate the highest amount of food …


Determinants Of Physicochemical Composition Of Palm Oil Mill Effluent - Implications On Environment And Bio-Digester Treatment Design, E.B. Tambe, A.U. Okonkwo, I.E. Mbuka-Nwosu, C.O. Cookey, E. Agbe, S.C. Onwusa, I.N. Ekpe, U.F. Evuen, J. Okpoghono Jan 2024

Determinants Of Physicochemical Composition Of Palm Oil Mill Effluent - Implications On Environment And Bio-Digester Treatment Design, E.B. Tambe, A.U. Okonkwo, I.E. Mbuka-Nwosu, C.O. Cookey, E. Agbe, S.C. Onwusa, I.N. Ekpe, U.F. Evuen, J. Okpoghono

Applied Environmental Research

Growing need for renewable energy and addressing challenges associated with indiscriminate wastes disposal has necessitated harnessing wastes to wealth. The study investigated parameters determining the physicochemical composition of palm oil mill effluent (POME) generated at Agricultural Development Authority Palm (ADAPALM) and palm oil mills in its catchment communities, located at Ohaji/ Egbema Local Government Area of Imo State, Nigeria and their implications on environmental health and treatment approaches required. Survey research design was used. From a randomly sampled small-scaled mill in each community, and for the lone medium and large-scaled mills, four homogenous samples of POME were collected from sampled …


Removal Of Chromium From Aqueous System Using Nanocellulose Prepared From Defoliated Terminalia Catappa Leaves, Lopamudra Digal, Jayashree Mohanty Jan 2024

Removal Of Chromium From Aqueous System Using Nanocellulose Prepared From Defoliated Terminalia Catappa Leaves, Lopamudra Digal, Jayashree Mohanty

Applied Environmental Research

Nanocellulose is considered as a sustainable and renewable nanomaterial due to its abundant availability, biodegradability and biocompatibility characteristics. The study demonstrates the synthesis of nanocellulose from defoliated leaves of the Tropical Almond (Terminalia catappa) plant, abundantly available residual plant biomass and its subsequent use in eliminating Cr(VI) from the water system. The study demonstrates the preparation of nanocellulose by chemical means, employing NaOH and H2SO4 as chemical agents. Characterization techniques like FTIR, SEM, and XRD were used to study the chemical composition and morphology of the resulting nanocellulose. The characterization studies confirm the formation of nanocellulose from the plant biomass. …