Digital Commons Network^™

Using Computational Thinking To Explore And Support Equity And Social Justice, Leslie Keiler, Sherone Smith-Sanchez, Zena Cooper, Natasha Cox-Magno, Lisa Dunn-Lockhart, Kara Hudon, Clare Pawson, Xin Bai

Publications and Research

Brief summary of presentation, suitable for inclusion in our conference program.

We explore the experience of teacher candidates who went to schools much like where they are preparing to teach. We investigate the implementation of Computational thinking-based (CT) learning experiences and examine the social justice implications. We investigate the impacts on their thinking about social justice and the faculty’s reflections on CT integration.

Leveraging The Power Of Storytelling To Encourage And Empower Children Towards Strong Passwords, Rizu Paudel, Mahdi Nasrullah Al-Ameen

Computer Science Student Research

With the increasing use of computer and smartphones by children, their online safety has been of major concern due to their limited security knowledge and skills. User authentication is pivotal for their security protection, where a body of work focused on children’s password practices. The insights from these studies highlight children’s lack of awareness and skills in creating a strong password. However, there is a dearth in existing literature to understand the scopes of designs for encouraging and empowering children towards strong passwords. As we begin to address this gap, we leveraged the power of storytelling to foster user attachment, …

The Importance Of Including Maternal Immune Activation In Animal Models Of Hypoxic-Ischemic Encephalopathy, Bailey Collins, Elise A. Lemanski, Elizabeth Wright-Jin

Department of Medicine Faculty Papers

Hypoxic-ischemic encephalopathy (HIE) is a perinatal brain injury that is the leading cause of cerebral palsy, developmental delay, and poor cognitive outcomes in children born at term, occurring in about 1.5 out of 1000 births. The only proven therapy for HIE is therapeutic hypothermia. However, despite this treatment, many children ultimately suffer disability, brain injury, and even death. Barriers to implementation including late diagnosis and lack of resources also lead to poorer outcomes. This demonstrates a critical need for additional treatments for HIE, and to facilitate this, we need translational models that accurately reflect risk factors and interactions present in …

Volume Cxliv, Number 7, November 8, 2024, Lawrence University

The Lawrentian

No abstract provided.

Plasma Proteome Alterations Of Laying Hens Subjected To Heat Stress And Fed A Diet Supplemented With Pequi Oil (Caryocar Brasiliense Camb.): New Insights In The Identification Of Heat Stress Biomarkers, Joyce Da Silva, Luane Andrade, Paola Rodrigues, Laís Cordeiro, Gabrieli Lima, Júlia Lopes, Elis Castillo, Renata Martins, Andrey Assunção, José Vieira, Marília Busalaf, Jiri Adamec, José Sartori, Pedro Padilha

School of Medicine Faculty Publications

Heat stress can disrupt the balance between the heat poultry release into the environment and the heat they generate. Pequi oil has antioxidant properties, which may mitigate the heat stress effects. This study aimed to investigate the response of laying hens to pequi oil supplementation under heat stress using a proteomic approach. A total of 96 Lohmann White laying hens with 26 weeks old were housed in a completely randomized design with a 2 × 2 factorial arrangement. They were housed in two climate chambers, thermal comfort temperature ± 24.04 °C with the relative humidity ± 66.35 and heat stress …

Flocs As Vectors For Microplastics In The Aquatic Environment, Nan Wu, Stuart Grieve, Andrew Manning, Kate Spencer

School of Biological and Marine Sciences

No abstract provided.

Microglia Drive Diurnal Variation In Susceptibility To Inflammatory Blood-Brain Barrier Breakdown, Jennifer H. Lawrence, Asha Patel, Melvin W. King, Collin J. Nadarajah, Richard Daneman, Erik S. Musiek

2020-Current year OA Pubs

The blood-brain barrier (BBB) is critical for maintaining brain homeostasis but is susceptible to inflammatory dysfunction. While transporter-dependent efflux of some lipophilic substrates across the BBB shows circadian variation due to rhythmic transporter expression, basal transporter-independent permeability and leakage is nonrhythmic. Whether daily timing influences BBB permeability in response to inflammation is unknown. Here, we induced systemic inflammation through repeated LPS injections either in the morning (ZT1) or evening (ZT13) under standard lighting conditions; we then examined BBB permeability to a polar molecule that is not a transporter substrate, sodium fluorescein. We observed clear diurnal variation in inflammatory BBB permeability, …

The Rna Receptor Rig-I Binding Synthetic Oligodeoxynucleotide Promotes Pneumonia Survival, Yongxing Wang, Vikram V Kulkarni, Jezreel Pantaleóngarcía, Michael K Longmire, Mathilde Lethier, Stephen Cusack, Scott E Evans

Faculty, Staff and Student Publications

Pneumonia is a worldwide threat to public health, demanding novel preventative and therapeutic strategies. The lung epithelium is a critical environmental interface that functions as a physical barrier to pathogen invasion while also actively sensing and responding to pathogens. We have reported that stimulating lung epithelial cells with a combination therapeutic consisting of a diacylated lipopeptide and a synthetic CpG oligodeoxynucleotide (ODN) induces synergistic pneumonia protection against a wide range of pathogens. We report here that mice deficient in TLR9, the previously described receptor for ODN, still displayed partial ODN-induced protection. This prompted us to seek an alternate ODN receptor, …

Editorial: Sustainable Aquaculture Production For Improved Food Security, Kwasi Adu Obirikorang, Kwamena Quagrainie, Jemimah Etornam Kassah, Mathis Von Ahnen

Department of Agricultural Economics Faculty Publications

No abstract provided.

Multi-Organ Gene Expression Analysis And Network Modeling Reveal Regulatory Control Cascades During The Development Of Hypertension In Female Spontaneously Hypertensive Rat, Eden Hornung, Sirisha Achanta, Alison Moss, James S. Schwaber, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Hypertension is a multifactorial disease with stage-specific gene expression changes occurring in multiple organs over time. The temporal sequence and the extent of gene regulatory network changes occurring across organs during the development of hypertension remain unresolved. In this study, female spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats were used to analyze expression patterns of 96 genes spanning inflammatory, metabolic, sympathetic, fibrotic, and renin-angiotensin (RAS) pathways in five organs, at five time points from the onset to established hypertension. We analyzed this multi-dimensional dataset containing ~15,000 data points and developed a data-driven dynamic network model that accounts for …

Modeling Antisense Oligonucleotide Therapy In Mecp2 Duplication Syndrome Human Ipsc-Derived Neurons Reveals Gene Expression Programs Responsive To Mecp2 Levels, Sameer S Bajikar, Yehezkel Sztainberg, Alexander J Trostle, Harini P Tirumala, Ying-Wooi Wan, Caroline L Harrop, Jesse D Bengtsson, Claudia M B Carvalho, Davut Pehlivan, Bernhard Suter, Jeffrey L Neul, Zhandong Liu, Paymaan Jafar-Nejad, Frank Rigo, Huda Y Zoghbi

Faculty, Staff and Students Publications

Genomic copy-number variations (CNVs) that can cause neurodevelopmental disorders often encompass many genes, which complicates our understanding of how individual genes within a CNV contribute to pathology. MECP2 duplication syndrome (MDS or MRXSL in OMIM; OMIM#300260) is one such CNV disorder caused by duplications spanning methyl CpG-binding protein 2 (MECP2) and other genes on Xq28. Using an antisense oligonucleotide (ASO) to normalize MECP2 dosage is sufficient to rescue abnormal neurological phenotypes in mouse models overexpressing MECP2 alone, implicating the importance of increased MECP2 dosage within CNVs of Xq28. However, because MDS CNVs span MECP2 and additional genes, we generated human …

Ephb4-Rasa1 Inhibition Of Piezo1 Ras Activation Drives Lymphatic Valvulogenesis, Di Chen, Yipei Tang, Philip E Lapinski, David Wiggins, Eva M Sevick, Michael J Davis, Philip D King

Faculty, Staff and Student Publications

BACKGROUND: EPHB4 (ephrin receptor B4) and the RASA1 (p120 Ras GTPase-activating protein) are necessary for the development of lymphatic vessel (LV) valves. However, precisely how EPHB4 and RASA1 regulate LV valve development is unknown. In this study, we examine the mechanisms by which EPHB4 and RASA1 regulate the development of LV valves.

METHODS: We used LV-specific inducible EPHB4-deficient mice and EPHB4 knockin mice that express a form of EPHB4 that is unable to bind RASA1 yet retains protein tyrosine kinase activity (EPHB4 2YP) to study the role of EPHB4 and RASA1 in LV valve development in the embryo and LV …

Hurp Facilitates Spindle Assembly By Stabilizing Microtubules And Working Synergistically With Tpx2, Venecia Alexandria Valdez, Meisheng Ma, Bernardo Gouveia, Rui Zhang, Sabine Petry

2020-Current year OA Pubs

In vertebrate spindles, most microtubules are formed via branching microtubule nucleation, whereby microtubules nucleate along the side of pre-existing microtubules. Hepatoma up-regulated protein (HURP) is a microtubule-associated protein that has been implicated in spindle assembly, but its mode of action is yet to be defined. In this study, we show that HURP is necessary for RanGTP-induced branching microtubule nucleation in Xenopus egg extract. Specifically, HURP stabilizes the microtubule lattice to promote microtubule formation from γ-TuRC. This function is shifted to promote branching microtubule nucleation through enhanced localization to TPX2 condensates, which form the core of the branch site on microtubules. …

Evaluating The Effectiveness Of Personalized Wet Lab Training On Phacoemulsification Surgery Learning Curve, Karen L. Christopher, Jennifer L. Patnaik, Cara E Capitena Young, Jeffrey R Soohoo, Michael J. Taravella, Mina B. Pantcheva

Journal of Academic Ophthalmology

Purpose To assess the impact of individualized one-on-one wet lab training on the learning curve of phacoemulsification cataract surgery among ophthalmology residents. Methods This prospective study involved 15 ophthalmology residents at a single institution between 2016 and 2019. Each resident participated in tailored training sessions focusing on phacoemulsification surgical steps, guided by an experienced cataract surgeon. Proficiency across 11 procedural steps was evaluated using a 5-level ordinal scale, and data on complications, case times, and proficiency scores were collected and analyzed using multiple regression models. Competency was defined as resident trainee performance of a surgical case without complication and level …

Dynamic Pricing System For Recommerce Transaction, Madhusudan St

Defensive Publications Series

The present disclosure related to a technique for real-time dynamic pricing recommendations. The technique includes fetching historical data and transactional information related to the plurality of products and corresponding similar products based on queries. The technique further include calculating optimal pricing recommendations based on the fetched historical data and transactional information. Subsequently, the technique include distributing price recommendations for recommerce transaction to the plurality of merchants

“No Te Voy A Dejar Nunca”: Culture And Second Language Acquisition For Survival In Fear The Walking Dead, Sharon M. Nuruddin

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Popular culture reinforces and shapes the beliefs and values of the individual, the community, and the masses. It can also transmit hidden messages about aspects of human behavior that are reiterated in scholarly research. In the field of education, particularly in world language teacher education, film and television can be used as an effective tool for examining how we acquire a second language. Using a symbolic convergence theory perspective (SCT) (Bormann, 1972), I employ Sellnow’s (2014) three-step process for the rhetorical analyses of mediated popular culture texts to reveal “covert messages” (p. 9) within the popular American Movie Channel (AMC) …

Criminals As Heroes: Problems And Pedagogy In Popular Culture [Dialogue: The Interdisciplinary Journal Of Popular Culture And Pedagogy Volume 6, Issue 2 (August 2019)], Anna S. Cohenmiller, Kelli Bippert

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Criminals as Heroes: Problems and Pedagogy in Popular Culture [Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy Volume 6, Issue 2 (August 2019)]

Editorial

Critically Evaluating the Fictional World through Popular Culture, Kelly Bippert and Anna CohenMiller

Guest Editorial

What Hot Criminals, Anti-Heroes, and Bob Dylan Can Teach Us, Kathryn (“Kate”) Lane and Roxie James

Articles

If Androids Dream, Are They More Than Sheep?: Westworld, Robots and Legal Rights, Amanda DiPaolo

Nature vs. Nurture in Albuquerque: What Breaking Bad and Better Call Saul Teach Us About How We Talk about Criminals, Max Romanowski

Breaking the Rules: Playing Criminally in …

Breaking The Rules: Playing Criminally In Video Games, James Tregonning

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Video games have long courted controversy for their frequent valorisation of criminality. However, in this article, I consider heroic criminals in video games from a different perspective. I focus on two games – Lucas Pope’s Papers, Please (2013) and Osmotic Studio’s Orwell (2016) – that position the player as a low-level government operative in a fictional authoritarian regime. Players are expected to process information for their governments, although they are also given opportunities to undermine or subvert the regime. Thus, the trope of heroic criminal is used to comment on the function and role of the state. It becomes …

Nature Vs. Nurture In Albuquerque: What Breaking Bad And Better Call Saul Teach Us About How We Talk About Criminals, Max Romanowski

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Breaking Bad and Better Call Saul focus on the criminal transformation of their two main characters, Walter White (Bryan Cranston) and Jimmy McGill (Bob Odenkirk). While quite similar on the surface, Walter and Jimmy’s narratives represent two different criminal transitions, evoking the classic nature vs nurture conversation. Both of these shows bring the conversation to the idea of inevitability. The nature vs. nurture argument is a popular one because it acts as a teaching tool for how we think and talk about criminal behavior. At first, it follows that since criminality was in Walter White’s nature the whole time, his …

If Androids Dream, Are They More Than Sheep?: Westworld, Robots And Legal Rights, Amanda J. Dipaolo

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

The robot protagonists in HBO’s Westworld open the door to several philosophical and ethical questions, perhaps the most complex being: should androids be granted similar legal protections as people? Westworld offers its own exploration of what it means to be a person and places emphasis on one’s ability to feel and understand pain. With scientists and corporations actively working toward a future that includes robots that can display emotion in a way that can convincingly pass as that of a person’s, what happens when androids pass the Turing test, feel empathy, gain consciousness, are sentient, or develop free will? The …

Vol. 35, No. 12 - Whole No. 201, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 35, No. 9 - Whole No. 198, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 35, No. 7 - Whole No. 196, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 35, No. 6 - Whole No. 195, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Studying Silence In Popular Culture, Kathy Merlock Jackson, Terry Lindvall

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

This article explains the impetus for and execution of a team-taught, interdisciplinary class in silence using popular culture materials and practices, such as silent film, music, meditation, and mime. The course identifies individuals as possessing characteristics of introversion and extraversion and explores the role of silence in the modern world, incorporating the following: (1) Foundations for the Study of Silence, (2) The History of Silence, (3) The Role of Silence in Spirituality, Creativity and Reflection, (4) Silence in Communication Study, (5) Silent Film and Silence in Film, (6) The Role of Silence in a Highly Technological, Mediated World, and (7) …

Making The Case For Teaching Character Change In Complex Tv: The Closer And Major Crimes, Emily C. Hoffman

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Jason Mittel’s 2015 book Complex TV: The Poetics of Contemporary Television Storytelling offers enough material to sustain a semester-long undergraduate course. Because of its approachability and students’ interest in discussing characters, his chapter devoted to viewers’ parasocial relationships and characters’ potential for change is among the most teachable. However, teaching complex television that relies on intensely serialized story elements can make choosing televisual texts for study and discussion challenging. Therefore, series that skew episodic yet still incorporate serial elements, like police procedurals, can prove to be a practical alternative for classroom study. This article describes how using the interrelated …

“Every Time I Write A Rhyme / These People Think It’S A Crime”: Persona Problems In Catullus And Eminem, Jesse Weiner

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

This essay interprets Eminem’s song, “Criminal” (2000, The Marshall Mathers LP, Track 18), as a Catullan project in establishing distance between the poet and poetic persona, accomplished through Catullan invective. Drawing upon pedagogical experience, I argue that Catullus (a Roman poet of the 1st Century BCE) and Eminem use analogous rhetorical tactics and structures to challenge accusations (real or imagined) of poor character stemming from their poetry. Catullus and Eminem vociferously articulate a separation of art from artist, using common transgressive poetics. Each poet disavows his own self-constructed stance of authenticity with similar threats of violence and postures of …

Using A Rabbit Model To Understand The Impact Of Oral Versus Intravenous Transmission Of Epstein-Barr Virus, Meera Mohammed Al Ameri

Thesis/ Dissertation Defenses

The isolation of Epstein-Barr Virus (EBV) in 1964 from a case of Burkitt lymphoma prompted a surge in research on the biology of this oncogenic virus and its role in the pathogenesis of associated malignancies. Over half a century later, a number of pertinent questions on the dynamics of EBV and the cellular targets of primary infection remain poorly defined. One major obstacle in EBV research has been the lack of a suitable small animal model. EBV is a highly human tropic virus. We have recently established a novel rabbit model of EBV infection that appears to mimic natural infection …

We All Have Jobs Here: Teaching And Learning With Multiple Intelligences In The Walking Dead, Lizabeth Gartley

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

With the rise of cultural studies, positivism and formalism fell out of favor. But in recent years, altered versions of these methodologies have been suggested as solutions to the deficiencies of the ideological approach dominating the field. Where the ideological approach looks at the content of texts to determine their meaning, the aesthetic approach adopted by media scholars in recent years returns to the close textual readings of formalism (while abandoning its assertion that meaning resides in the text alone). Similarly, where the ideological approach tends to use textual analysis devoid of sociological empiricism, the use of “big data” in …

Where Do Gorillas Get Their Protein? Plant-Based Diet For A Healthier Lifestyle, Cheryl Track

International Journal of Faith Community Nursing

After watching what they thought to be an interesting and educational documentary on nutrition, my friends, Sharon and Scott, felt inspired to challenge themselves by undertaking some dietary changes apart from their regular eating habits. What started out as a short “trial run” to explore plant-based dieting, Sharon and Scott quickly realized this alternative eating style proved beneficial. In a short period of time, two individuals with their own fitness and wellness goals saw noticeable changes in lab results and experienced positive changes to their overall health – enough evidence leaving them convinced the “trial run” with plant-based dieting should …