Digital Commons Network^™

G-Quadruplex Dna And Rna In Cellular Senescence, Rocio Diaz Escarcega, Paul Marshall, Andrey S Tsvetkov

Faculty, Staff and Student Publications

Normal cells divide, are damaged, and are repaired across their lifetime. As cells age, they enter cellular senescence, characterized by a permanent state of cell-cycle arrest triggered by various stressors. The molecular mechanisms that regulate senescent phenotypes have been actively investigated over the last several decades; however, one area that has been neglected is how G-quadruplex (G4) DNA and RNA (G4-DNA and G4-RNA) mediate senescence. These non-canonical four-stranded DNA and RNA structures regulate most normative DNA and RNA-dependent processes, such as transcription, replication, and translation, as well as pathogenic mechanisms, including genomic instability and abnormal stress granule function. This review …

Clic1-Mediated Autophagy Confers Resistance To Ddp In Gastric Cancer, Zhen-Liang Nong, Kun Zhao, Ye Wang, Zhu Yu, Cong-Jun Wang, Jun-Qiang Chen

Faculty, Staff and Student Publications

Gastric cancer has been a constant concern to researchers as one of the most common malignant tumors worldwide. The treatment options for gastric cancer include surgery, chemotherapy and traditional Chinese medicine. Chemotherapy is an effective treatment for patients with advanced gastric cancer. Cisplatin (DDP) has been approved as a critical chemotherapy drug to treat various kinds of solid tumors. Although DDP is an effective chemotherapeutic agent, many patients develop drug resistance during treatment, which has become a severe problem in clinical chemotherapy. This study aims to investigate the mechanism of DDP resistance in gastric cancer. The results show that intracellular …

A Novel Assessment Of Whole-Mount Gleason Grading In Prostate Cancer To Identify Candidates For Radical Prostatectomy: A Machine Learning-Based Multiomics Study, Jing Ning, Clemens P Spielvogel, David Haberl, Karolina Trachtova, Stefan Stoiber, Sazan Rasul, Vojtech Bystry, Gabriel Wasinger, Pascal Baltzer, Elisabeth Gurnhofer, Gerald Timelthaler, Michaela Schlederer, Laszlo Papp, Helga Schachner, Thomas Helbich, Markus Hartenbach, Bernhard Grubmüller, Shahrokh F Shariat, Marcus Hacker, Alexander Haug, Lukas Kenner

Faculty, Staff and Student Publications

Purpose: This study aims to assess whole-mount Gleason grading (GG) in prostate cancer (PCa) accurately using a multiomics machine learning (ML) model and to compare its performance with biopsy-proven GG (bxGG) assessment.

Materials and Methods: A total of 146 patients with PCa recruited in a pilot study of a prospective clinical trial (NCT02659527) were retrospectively included in the side study, all of whom underwent ⁶⁸Ga-PSMA-11 integrated positron emission tomography (PET) / magnetic resonance (MR) before radical prostatectomy (RP) between May 2014 and April 2020. To establish a multiomics ML model, we quantified PET radiomics features, pathway-level genomics …

Toxicity In The Era Of Immune Checkpoint Inhibitor Therapy, Synat Keam, Naimah Turner, Fernanda G Kugeratski, Rene Rico, Jocelynn Colunga-Minutti, Rayansh Poojary, Sayan Alekseev, Anisha B Patel, Yuanteng Jeff Li, Ajay Sheshadri, Monica E Loghin, Karin Woodman, Ashley E Aaroe, Sarah Hamidi, Priyanka Chandrasekhar Iyer, Nicolas L Palaskas, Yinghong Wang, Roza Nurieva

Faculty, Staff and Student Publications

Immune checkpoint inhibitors (ICIs) reinvigorate anti-tumor immune responses by disrupting co-inhibitory immune checkpoint molecules such as programmed cell death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4). Although ICIs have had unprecedented success and have become the standard of care for many cancers, they are often accompanied by off-target inflammation that can occur in any organ system. These immune related adverse events (irAEs) often require steroid use and/or cessation of ICI therapy, which can both lead to cancer progression. Although irAEs are common, the detailed molecular and immune mechanisms underlying their development are still elusive. To further our understanding …

A Pthrp Gradient Drives Mandibular Condylar Chondrogenesis Via Runx2, C Tsutsumi-Arai, Y Arai, A Tran, M Salinas, Y Nakai, S Orikasa, W Ono, N Ono

Faculty, Staff and Student Publications

The mandibular condylar cartilage (MCC) is an essential component of the temporomandibular joint, which orchestrates the vertical growth of the mandibular ramus through endochondral ossification with distinctive modes of cell differentiation. Parathyroid hormone–related protein (PTHrP) is a master regulator of chondrogenesis; in the long bone epiphyseal growth plate, PTHrP expressed by resting zone chondrocytes promotes chondrocyte proliferation in the adjacent layer. However, how PTHrP regulates chondrogenesis in the MCC remains largely unclear. In this study, we used a Pthrp-mCherry knock-in reporter strain to map the localization of PTHrP+ cells in the MCC and define the function of PTHrP in the …

Independent Regulation Of Piezo1 Activity By Principal And Intercalated Cells Of The Collecting Duct, Kyrylo Pyrshev, Anna Atamanchuk-Stavniichuk, Mariya Kordysh, Oleg Zaika, Viktor N Tomilin, Oleh Pochynyuk

Faculty, Staff and Student Publications

The renal collecting duct is continuously exposed to a wide spectrum of fluid flow rates and osmotic gradients. Expression of a mechanoactivated Piezo1 channel is the most prominent in the collecting duct. However, the status and regulation of Piezo1 in functionally distinct principal and intercalated cells (PCs and ICs) of the collecting duct remain to be determined. We used pharmacological Piezo1 activation to quantify Piezo1-mediated [Ca2+]i influx and single-channel activity separately in PCs and ICs of freshly isolated collecting ducts with fluorescence imaging and electrophysiological tools. We also employed a variety of systemic treatments to examine their consequences on Piezo1 …

Rare Genomic Copy Number Variants Implicate New Candidate Genes For Bicuspid Aortic Valve, Steven G Carlisle, Hasan Albasha, Hector I Michelena, Anna Sabate-Rotes, Lisa Bianco, Julie De Backer, Laura Muiño Mosquera, Anji T Yetman, Malenka M Bissell, Maria Grazia Andreassi, Ilenia Foffa, Dawn S Hui, Anthony Caffarelli, Yuli Y Kim, Dongchuan Guo, Rodolfo Citro, Margot De Marco, Justin T Tretter, Kim L Mcbride, Dianna M Milewicz, Simon C Body, Siddharth K Prakash, Ebav Investigators, Bavcon Investigators

Faculty, Staff and Student Publications

Bicuspid aortic valve (BAV), the most common congenital heart defect, is a major cause of aortic valve disease requiring valve interventions and thoracic aortic aneurysms predisposing to acute aortic dissections. The spectrum of BAV ranges from early onset valve and aortic complications (EBAV) to sporadic late onset disease. Rare genomic copy number variants (CNVs) have previously been implicated in the development of BAV and thoracic aortic aneurysms. We determined the frequency and gene content of rare CNVs in EBAV probands (n = 272) using genome-wide SNP microarray analysis and three complementary CNV detection algorithms (cnvPartition, PennCNV, and QuantiSNP). Unselected control …

The Immunobiology Of Myelodysplastic Neoplasms: A Mini-Review, Shruthi Kannan, Rolando A Vedia, Jeffrey J Molldrem

Faculty, Staff and Student Publications

This mini review summarizes the immunobiology of myelodysplastic syndromes, specifically focusing on the interactions between immune cells, cytokines, and dysplastic cells within the tumor microenvironment in the bone marrow. We elucidate in detail how immune dysregulation and evasion influence the initiation and progression of myelodysplastic syndromes, as well as resistance to therapy and progression to AML. In addition, we highlight a range of therapeutic strategies, including the most recent breakthroughs and experimental therapies for treating MDS. Finally, we address the existing knowledge gaps in the understanding of the immunobiology of MDS and propose future research directions, promising advancements toward enhancing …

Nasal Bots Carry Relevant Titers Of Cwd Prions In Naturally Infected White-Tailed Deer, Paulina Soto, Francisca Bravo-Risi, Carlos Kramm, Nazaret Gamez, Rebeca Benavente, Denise L Bonilla, J Hunter Reed, Mitch Lockwood, Terry R Spraker, Tracy Nichols, Rodrigo Morales

Faculty, Staff and Student Publications

Chronic wasting disease (CWD) is a prion disease affecting farmed and free-ranging cervids. CWD is rapidly expanding across North America and its mechanisms of transmission are not completely understood. Considering that cervids are commonly afflicted by nasal bot flies, we tested the potential of these parasites to transmit CWD. Parasites collected from naturally infected white-tailed deer were evaluated for their prion content using the protein misfolding cyclic amplification (PMCA) technology and bioassays. Here, we describe PMCA seeding activity in nasal bot larvae collected from naturally infected, nonclinical deer. These parasites efficiently infect CWD-susceptible mice in ways suggestive of high infectivity …

Have You Been To Orlando?: In Relation To The Regulation Of Self-Preferencing In Antitrust Law, Eunkwang Ha

South Carolina Journal of International Law and Business

As a mother of two and a South Korean professional studying abroad in the United States, one of my top priorities for our family's time here was to visit Orlando. My children had endured quite a bit of disruption as I pursued my professional goals, and I felt visiting Disney World and Universal Studios would be a bit of recompense. Although I wanted to use a package deal from a Korean travel agency, it was not a good choice because I needed to stay at hotels connected to Disney World and Universal Studios.

Due to the self-preferencing of Disney World …

Lidar From The Sky: Uav Integration And Fusion Techniques For Advanced Traffic Monitoring, Baya Cherif, Hakim Ghazzai, Ahmad Alsharoa

Electrical and Computer Engineering Faculty Research & Creative Works

Light detection and ranging (LiDAR) technology's expansion within the autonomous vehicles industry has rapidly motivated its application in numerous growing areas, such as smart cities, agriculture, and renewable energy. In this article, we propose an innovative approach for enhancing aerial traffic monitoring solutions through the application of LiDAR technology. The objective is to achieve precise and real-time object detection and tracking from aerial perspectives by integrating unmanned aerial vehicles with LiDAR sensors, thereby creating a potent Aerial LiDAR (A-LiD) solution for traffic monitoring. First, we develop a novel deep learning algorithm based on pointvoxel-region-based convolutional neural network (RCNN) to conduct …

Baker's Novelty Plays, Script, Boston, Massachusetts, 1894

Documents

Baker's Novelty Plays script for "The District School at Blueberry Corners, A Farcical Entertainment in Three Scenes" by Laura M. Parsons, 22 pages, Walter H. Baker Company, Boston, Massachusetts, 1894. Signed by Walter H. Baker.

St. James Theatre, Playbill, New York, New York, 1937

Documents

St. James Theatre, playbill for "King Richard II." by William Shakespeare, starring Maurice Evans and Ian Keith, staged by Margaret Webster, New York, New York, beginning 1937 March 8.

Theatre Memphis, Program, Memphis, Tennessee, 1989

Documents

Theatre Memphis, program for "Big River, The Adventure of Huckleberry Finn," music and lyrics by Roger Miller, book by William Hauptman, directed by Sherwood Lohrey, Memphis, Tennessee, 70th Anniversary Mainstage Season, 1989 September 7-24.

Magazine Article, "Beale Street Sings The Blues No More," From The Downtowner, Memphis, Tn, November 1993

Documents

Magazine article, "Beale Street Sings The Blues No More," by Paul Gerald, The Downtowner, Memphis, TN, Vol. 3, Issue 10, November 1993.

The Oswald Review Of Undergraduate Research And Criticism In The Discipline Of English: Volume 26, 2024, Douglas Higbee

The Oswald Review: An International Journal of Undergraduate Research and Criticism in the Discipline of English

No abstract provided.

Colonial Body-Logic In George Orwell's Burnese Days: A Contrapuntal Critique, Riley Mays

The Oswald Review: An International Journal of Undergraduate Research and Criticism in the Discipline of English

No abstract provided.

Controlled Substance Monitoring Database; 2024 Report To The 113th Tennessee General Assembly, Tennessee. Department Of Health.

Controlled Substance Monitoring Database Annual Report

No abstract provided.

Laboratory Evaluation Of Essential Oils Extracted From Peppermint And Eucalyptus Plants Against The Rat Flea (Xynopsylla Cheopis) And Evaluate Their Effects On Some Vital Process In Albino Rat, Rasha Ragheb Hassan, Micheal William Mikhail

Journal of Medicine in Scientific Research

The effectiveness of peppermint and eucalyptus oils was examined in the current study to the rat fleas (Xenopsylla cheopis). The constituents of each oil were identified by GC-MS. The LC50 and LC90 for each essential oil were calculated after 1 and 24 hours exposure. The effect of peppermint and eucalyptus oils on some vital process in albino rat treated with 1/10 and 1/20 of LD50 were studied for the ALT, AST, Urea and creatinine levels. TNF-α and IL-6 levels also were studied. Data indicated that peppermint essential oil had more efficacy than that of eucalyptus for 1 and 24 hours …

In Pursuit Of Equity Under Nepa: Apalachicola’S Invisibility In The Tristate Water Wars, Abigail E. Andre

University of Memphis Law Review

In the presence of significant environmental impacts, the National Environmental Policy Act (“NEPA”) requires agencies to take a hard look at community effects. However, analysis of human impacts under NEPA is generally cursory. While executive orders requiring consideration of environmental justice have raised awareness of community impacts in some instances, agency approach is inconsistent, and courts largely view such analysis as a box to be checked. Such cursory consideration of human impacts leaves historically underserved communities in a legal blind spot that perpetuates environmental and procedural inequity. Using the U.S. Army Corps of Engineers’ management of the Apalachicola, Chattahoochee, and …

Rural Health Care In The Age Of Hospital Bankruptcies, Sonal Rastogi

Emory Bankruptcy Developments Journal

In recent years, the United States has witnessed a surge in bankruptcy filings within the healthcare sector. Inflation, rising expenses, shifts in payment models, labor shortages, legislative uncertainty, and mounting pharmaceutical costs have impacted all healthcare organizations, casting a shadow over communities. This is particularly evident in rural America where hospital closures have shrunk access to healthcare services. This Comment delves into the challenges and interests at play when healthcare entities and nonprofit organizations navigate bankruptcy proceedings, paying particular attention to the challenges faced by health care business bankruptcy proceedings.

This Comment argues that the current bankruptcy framework requires adjustments …

What A Waste: Nitrogen Runoff And Rates In The Maumee River (Ohio, Usa), Ryanne Antonette Cimatu

Browse all Theses and Dissertations

Excess anthropogenic nitrogen (N), primarily from agricultural field fertilization, causes nutrient runoff that stimulates harmful algal blooms (HABs) in western Lake Erie. As a critical tributary to Lake Erie, nutrient loading from the Maumee River drives the intensity of the annual summer HABs in the western basin. Knowledge gaps around rates of N transformations in the Maumee River currently hinder the calibration of in-river parameters in Soil and Water Assessment Tool (SWAT) models for the Maumee watershed. To address these gaps, this research quantified rates of ammonium uptake, ammonium remineralization, nitrification, and bacterial respiration alongside physicochemical parameters of the river. …

Biomechanical Simulation Of Cardiovascular Implantable Electronic Device Leads With Residual Properties, Anmar Mahdi Salih

Browse all Theses and Dissertations

Implantable leads used in pacemakers, defibrillators, and cardiac resynchronization therapy are designed for in-vivo applications, yet their longevity is inevitably shaped by the conditions within the human body. The mechanical behavior of these leads can be affected over time, necessitating the evaluation of their residual properties. Two main insulators, silicone, and polyurethane are commonly used for the outer insulation of cardiac leads. Understanding the long-term performance of these insulators is crucial for ensuring the reliability and safety of cardiac implantable devices. The research aims to assess the long-term mechanical properties and performance of implantable leads utilized in cardiovascular implantable electronic …

The Relationship Between Aim Pathways Professional Development, Teachers’ Sense Of Efficacy For Literacy Instruction, And Literacy Knowledge, Among K-3 Teachers, Shakita Bagwell

Electronic Theses and Dissertations

Teaching reading has been an ongoing challenge for many educators across the United States. Numerous studies suggest that teachers feel they were not adequately prepared to teach reading and have low efficacy in delivering literacy instruction. Teaching reading requires educators to be knowledgeable about the alphabetic principle, decoding new words, and how the brain learns to read. This exploratory study aimed to investigate the relationship between AIM Pathways Professional Development on teachers’ literacy efficacy and knowledge compared to teachers who did not receive the professional development. A survey was administered to eighty-eight teachers in Mississippi Literacy Support Schools. Multidimensional scaling …

More Than A Feeling: Materializing Sympathy In Nineteenth-Century American Literature, Kathleen Downes

Electronic Theses and Dissertations

“More than a Feeling: Materializing Sympathy in Nineteenth-Century American Literature” breaks from a long tradition of criticism that only considers the nineteenth-century belief that sympathy was a benevolent, voluntary, imaginative act of feeling that maintains moral rectitude through the identification of suffering with others. In this context, sympathy is primarily defined as identificatory sympathy. “More than a Feeling” expands the definition of sympathy in the nineteenth century as also something that could be atmospherically communicated, transmitting good or bad feeling, and thus affecting and infecting those around them. This other form of sympathy, which for this project I term “effluvial …

Mississippi's America: Late Southern Writing On National Themes, Jacob Fennell

Electronic Theses and Dissertations

This project examines three texts each from three Mississippi authors working today: Kiese Laymon, Jesmyn Ward, and Mary Miller. These authors’ literary constructions of their home state and the South as a whole serve as critical, political frames for the United States. As a result, their work is well-served by the questions and methodology of New Southern Studies, a field actively invested in conceptions of the U.S. South as nonexceptional and lodged within greater geopolitical contexts. Indeed, the original call for New Southern Studies from Houston A. Baker, Jr. and Dana Nelson speaks to a problem of a false national …

Running In The Rain: Stories, Vinh Hoang

Electronic Theses and Dissertations

A short story collection.

As Lightning, Lenna Mendoza

Electronic Theses and Dissertations

A collection of poems.

Montesquieu: The Nature Of L’Esprit Des Lois, Christian Jax Murray

Electronic Theses and Dissertations

When Baron de Montesquieu received a copy of his L’Esprit des lois, he was horrified by the total removal and reorganization of critical parts of his text, changed ideas, and an abnormal amount of printing errors in his work. While he saw these issues hindering the reception of his work, this thesis argues that the chaos of the text, in both its style and publication, made the book more popular instead of hindering it. Montesquieu, his editor, and his publisher constructed a new kind of text that was broad in its subject matter and ambiguous in its meaning where its …

Stabilized Fingolimod Nanoemulsion Ophthalmic Formulation For The Treatment Of Retinal Degeneration, Mekhala Sharad Naik

Electronic Theses and Dissertations

Fingolimod (FTY) is a sphingosine-1-phosphate receptor agonist and an inhibitor of ceramide synthase, reducing cellular ceramide levels and mitigating photoreceptor degeneration. The current research focuses on enhancing the stability of a previously reported FTY nanoemulsion (FTY-NE) topical (eyedrop) ophthalmic formulation. However, FTY undergoes oxidative and base mediated hydrolytic degradation, and the previously reported formulation, although effective, failed within 90 days storage at room temperature. This study explores various approaches, such as addition of buffer, cosolvents, steric stabilizer, viscosity enhancer, emulsifying agent, and a chelating agent in the NE system to increase shelf-life. The FTY-NE formulations (0.3% drug load) were prepared …