Digital Commons Network^™

Project Wars: A Serious Game To Teach Decision Making In Project Execution, Cecil Eng Huang Chua, Veda C. Storey, Linda Wallace

Business and Information Technology Faculty Research & Creative Works

Project execution (i.e., the production, delivery, and deployment of an information system project's outputs) is a difficult concept to teach effectively because of the many real-time decision-making variables facing a project manager. This paper introduces Project Wars, a web-based serious game designed to teach the project execution concepts of deferral of gratification, organizational mindfulness, and discipline in the face of adversity. Project Wars serves as both a platform to instill these concepts and as a basis for discussions on other critical concepts. The latter includes project team management and control, project leadership, the relationship between productivity, slack, and overtime, and …

Investigating Ammonium Toxicity In The Performance Of Recirculating Periphytic Algal Wastewater Treatment Systems, Oluchuku Richie Ochonogor

Theses and Dissertations

Freshwater nutrient enrichment from wastewater facilities and other sources can lead to freshwater eutrophication, a threat to global aquatic ecosystems. Mechanical and chemical ways to curb this threat are either too expensive or not sustainable, and thus, not feasible. Compared to mechanical and other methods, sustainable, inexpensive biological methods (for example, algal treatment systems) have therefore been developed for the removal of excess nutrients from wastewater. By design, secondary waste treatment facilities (WWTF) remove organics and solids and lower oxygen demanding substances; however, they may not remove enough nutrients to protect freshwater ecosystems in all cases. While algae-based biological methods …

A Phytochemical Analysis Of Secondary Metabolites In Eupatorium Serotinum, Elise Snow

Theses and Dissertations

Phytochemistry, a subset of Natural Products Chemistry, studies chemically derived products from natural substances. Advances in this field have important applications in medicinal research due to the distinctive and unique properties of natural compounds. All metabolites are produced from the metabolic cycle, which is a pathway that provides energy for the organism. These metabolic compounds vary greatly and are classified based on their function within the organism. Primary metabolites are abundant and contribute to organism growth, development, and maintenance of energy. Secondary metabolites are found in lesser quantity and correlate to natural defense mechanisms. For example, salicylic acid is a …

What Does It Mean To Be A Human In The Age Of Artificial Intelligence?, Campbell R. Eubanks

Theses and Dissertations

Campbell Eubanks’ artwork reflects ideas surrounding the ever-growing complexities of human nature in the context of our growing world. She uses ceramics to investigate human purpose in a digital world by employing artificial intelligence along with her own skills and craft. Her work aims to challenge viewers to contemplate the intricate relationship between humans and artificial intelligence. During her research, Eubanks has looked towards other artists who invite AI into their traditional practices. Sougwen Chung is one example of this. Chung has trained AI robots to learn her style and works alongside them in performances to create collaborative gestural drawings. …

The Impact Of California Law Ab 948 On Patient Outcomes In Left Ventricular Outflow Tract Obstruction, Yvette Arzaga

Bachelor of Science in Diagnostic Ultrasound Projects

This literature review will explore if patients in California with left ventricular outflow tract obstruction (LVOTO) taking a single prescription medication that exceeds $250 per 30 day supply will benefit from the passing of California Law AB 948 titled Prescription Drugs in 2023.

A comprehensive literature review on papers comparing prescription medication effectiveness for LVOTO, medication dosing, and price for hypertrophic obstructive cardiomyopathy was completed. Research papers were written by doctors who have treated hypertrophic cardiomyopathy and researchers investigating new drug treatment success. Goodrx.com was used to price suggested pharmacological agents.

Seven drugs were priced at low and high doses. …

Climate Change And Critical Agrarian Studies, Ian Scoones, Saturnino M. Borras Jr., Amita Baviskar, Marc Edelman, Nancy Peluso, Wendy Wolford

Publications and Research

Climate change is perhaps the greatest threat to humanity today and plays out as a cruel engine of myriad forms of injustice, violence and destruction. The effects of climate change from human-made emissions of greenhouse gases are devastating and accelerating; yet are uncertain and uneven both in terms of geography and socio-economic impacts. Emerging from the dynamics of capitalism since the industrial revolution — as well as industrialisation under state-led socialism — the consequences of climate change are especially profound for the countryside and its inhabitants. The book interrogates the narratives and strategies that frame climate change and examines the …

A Rule-Based Hybrid Translation Model For Context-Aware Speech To Indian Sign Language Tasks, Dania Jaison

Master's Projects

In India, one of the most significant tools to communicate with the Deaf and Hard of Hearing (DHH) communities is Indian Sign Language(ISL). The issue of a scarcity of computational resources for ISL is even more pronounced when it comes to the translation of written or spoken English into ISL. This paper proposes a rule-based model for translation where the spoken english sentences are translated into ISL by focusing on the specific syntactic and grammatical differences between these two languages. ISL uses a simplified syntax unlike the nuanced sentence structures in English — we omit most of the auxiliary verbs …

Comparison Of Protein Structures Predicted By Genai Tools In A Zero-Shot Manner, Kruthi Shankar Rao

Master's Projects

Generative AI models have vast applications and one such critical application explored in this study is protein structure prediction. The 3D structures of proteins determine their function. Our study mainly focuses on using generative AI models such as ESMFold and ColabFold to predict and examine naturally occurring and mutated sequences. The workflow begins with collecting antimicrobial resistance (AMR) and toxin-antitoxin (TA) protein data. The sequences are applied over pretrained AI models to predict protein structures. Following this, models are fine-tuned with original and mutated target datasets. A comparison of models’ performances is done using metrics such as root mean square …

Facial Expression Mood Classification Using Machine Learning, Tiantong Li

Master's Projects

Facial expression classification is a powerful tool for understanding human emotions, with applications spanning human-computer interaction, healthcare, and entertainment. By analyzing facial cues, systems can interpret emotional states and adapt their responses, creating more personalized and emotionally aware experiences. One emerging application of facial expression classification is in music recommendation systems, where user emotions are integrated to suggest music that aligns with their current mood. While prior research has primarily classified facial expressions into four emotion categories, this study broadens the scope to seven emotions: angry, disgust, fear, happy, neutral, sad, and surprise. The project evaluates four machine learning techniques—CNN, …

Teaching Children Programming Concepts Through Video Games, Kayla Musleh

Master's Projects

Children have a tendency to lose focus when they are presented with something that does not entertain them or tailor to their personal interests; such as studying [1], [3], [10]. The research performed for this project focuses on studying how much more children can comprehend and focus on learning educational material if they are learning through playing a video game rather than being taught information directly in a typical classroom manner. For this study I created a computer game designed to introduce educational subjects such as mathematics and programming concepts to the child playing the game. By completing the tasks …

Is Mitigation Translocation An Effective Method For Reducing Laysan Albatross–Military Aircraft Collisions?, Brian E. Washburn, Katherine D. Rubiano, William P. Bukoski

Human–Wildlife Interactions

Wildlife–aircraft collisions (wildlife strikes) pose a serious risk to civil and military aircraft. Each year, Laysan albatrosses (Phoebastria immutabilis) attempt to establish a breeding colony on the airfield at the U.S. Navy’s Pacific Missile Range Facility (PMRF) located on the island of Kaua‘i, Hawai‘i, USA, resulting in a hazard to safe military aircraft operations at this facility. A long-term management program, with an emphasis on mitigation translocation (e.g., live-capture and translocation away from the area) of problematic individuals, has been conducted by the U.S. Department of Agriculture, Wildlife Services. However, the efficacy of mitigation translocation as a nonlethal …

Efficacy Of A Laser As A Starling Deterrent And Its Effect On Lactating Dairy Cow Behavior, Callan A. Lichtenwalter, Marcos Marcondes, Kyle R. Taylor, Craig Mcconnel, Amber Adams Progar

Human–Wildlife Interactions

European starlings (Sturnus vulgaris) cause damage (including structural damage) on dairies, eat cattle feed, and can potentially spread disease through their fecal matter. Deterring starlings from dairies without affecting cow (Bos taurus) welfare is vital, and lasers have been effective starling deterrence tools in urban roosts and in some crops. To evaluate if the use of lasers on dairies would affect starling use of freestall barns as night roosts, or lactating cow behavior, 1 laser was installed in each of the 2 freestall barns at the Knott Dairy Center at Washington State University, Pullman, Washington, USA. …

Snake Translocation Policies And Practices Within The United States, Robin E. Bedard, Megan Rottenborn, Emily Taylor

Human–Wildlife Interactions

Human–wildlife conflict with nuisance snakes (Serpentes) is rapidly increasing with human population growth and development rates. Translocation of nuisance snakes has become a widespread practice, aided by social media pages connecting people to volunteer and for-profit snake translocators. However, translocators often struggle to find information and resources from wildlife agencies about the policies required, and some may unintentionally use translocation procedures that disregard the health and survival of the snakes. The goals of this study were to (1) obtain data on policies, permitting, and training required for translocating nuisance snakes in each U.S. state that has snakes and (2) compare …

“Continuity Without Cultivation”?: The Student Figure, Legal Education, And Writing Pedagogy In India, Diya Deviah, Ammel Sharon

Socio-Legal Review

This paper reconstructs the historical figure of the student in India through the intertwined trajectories of writing pedagogy and legal education. Moving beyond the socio-political portrayal of students as agents of resistance or nation-building, it examines how the classroom can function as a dynamic site for meaning-making. Drawing on archival materials, including syllabi, composition manuals, and legal reform reports, the paper traces the role of English language education in shaping legal pedagogy from the colonial period to the establishment of contemporary National Law Universities. Situating these developments within broader debates in writing and composition studies, the paper proposes alternative pedagogical …

Cultivating Legalism From Paper Proofs: Analysing Everyday Forms Of Claim Making By Van Gujjar Pastoralists In Uttarakhand, Mohammad Meer Hamja, Pranav Menon

Socio-Legal Review

Scholarship from South Asia has often highlighted how subaltern peoples partake in social movements as figures of resistance but rarely analyse their techniques of working the law in their favour to negotiate citizenship with the state. Such modes of articulating claims through affective gestures and vernacular legalese foster plural meanings to otherwise rigid legal categories and dogmatic bureaucratic interpretation. This paper draws upon socio-historical and ethnographic accounts of Van Gujjars to highlight how these pastoralists utilise myriad forms of paper proofs and documentary evidence to engage in claim making across the forests of Uttarakhand. Through an articulation of everyday tactics …

Editorial, Manhar Bansal

Socio-Legal Review

No abstract provided.

Full Issue, Socio-Legal Review

Socio-Legal Review

No abstract provided.

A Case Study Of The Influence Of The Teacher Librarian On Middle And High School Student Book Selection, Hilary Peyton, Lindsay Salinas, Josie Smock, Meg Tisinger

Graduate Research Papers

This study examines the influence of the teacher librarian on middle and high school student book selection through library programming that includes teacher librarian book promotion strategies, specifically book talks, book displays, and genrefication in a school library. This qualitative case study of 60 Iowa middle and high school students aims to answer two questions: 1) What strategies do middle and high school students use for selecting books for pleasure reading? 2) How do teacher librarian book promotion strategies influence student selection of books for pleasure reading? Using participant surveys and interviews the study revealed 3 major themes: 1) Most …

Teacher Librarian Book Promotion: Bringing Motivation To The Forefront: A Research Proposal, Christy Bartels, Bree Dickens, Chris Frimml, Jennifer George, Kristel Groenewold

Graduate Research Papers

No abstract provided.

Protein-Centric Omics Analysis Reveals Circulating Complements Linked To Non-Viral Liver Diseases As Potential Therapeutic Targets, Yingzhou Shi, Hang Dong, Shiwei Sun, Xiaoqin Wu, Jiansong Fang, Jianbo Zhao, Junming Han, Zongyue Li, Huixiao Wu, Luna Liu, Wanhong Wu, Yang Tian, Guandou Yuan, Xiude Fan, Chao Xu

Faculty, Staff and Student Publications

BACKGROUND/AIMS: To evaluate the causal correlation between complement components and non-viral liver diseases and their potential use as druggable targets.

METHODS: We conducted Mendelian randomization (MR) to assess the causal role of circulating complements in the risk of non-viral liver diseases. A complement-centric protein interaction network was constructed to explore biological functions and identify potential therapeutic options.

RESULTS: In the MR analysis, genetically predicted levels of complement C1q C chain (C1QC) were positively associated with the risk of autoimmune hepatitis (odds ratio 1.125, 95% confidence interval 1.018-1.244), while complement factor H-related protein 5 (CFHR5) was positively associated with the risk …

Feasible Diet And Circadian Interventions Reduce In Vivo Progression Of Flt3-Itd-Positive Acute Myeloid Leukemia, Megan Rodriguez, Baharan Fekry, Brianna Murphy, Mary Figueroa, Tiewei Cheng, Margaret Raber, Lisa Wartenberg, Donna Bell, Lisa Triche, Karla Crawford, Huaxian Ma, Kendra Allton, Ruwaida Ahmed, Jaime Tran, Christine Ranieri, Marina Konopleva, Michelle Barton, Cesar Nunez, Kristin Eckel-Mahan, Joya Chandra

Faculty, Staff and Student Publications

BACKGROUND: Acute myeloid leukemia (AML) with an internal tandem duplication in the fms-like tyrosine kinase receptor 3 gene (FLT3-ITD) is associated with poor survival, and few studies have examined the impact of modifiable behaviors, such as nutrient quality and timing, in this subset of acute leukemia.

METHODS: The influence of diet composition (low-sucrose and/or low-fat diets) and timing of diet were tested in tandem with anthracycline treatment in orthotopic xenograft mouse models. A pilot clinical study to test receptivity of pediatric leukemia patients to macronutrient matched foods was conducted. A role for the circadian protein, BMAL1 (brain and muscle ARNT-like …

Developing Medical Genetics In A Low-Income Country: Unveiling The Journey Of The Pakistani Society Of Medical Genetics And Genomics (Psmg), Aisha Furqan, Syed A Ahmed, Rizwan Naeem, Myla Ashfaq

Faculty, Staff and Student Publications

No abstract provided.

Human Equilibrative Nucleoside Transporter 1: Novel Biomarker And Prognostic Indicator For Patients With Gemcitabine-Treated Pancreatic Cancer, Jianchun Xiao, Fangyu Zhao, Wenhao Luo, Gang Yang, Yicheng Wang, Jiangdong Qiu, Yueze Liu, Lei You, Lianfang Zheng, Taiping Zhang

Faculty, Staff and Student Publications

AIM: This article aimed to find appropriate pancreatic cancer (PC) patients to treat with Gemcitabine with better survival outcomes by detecting hENT1 levels.

METHODS: We collected surgical pathological tissues from PC patients who received radical surgery in our hospital from September 2004 to December 2014. A total of 375 PC tissues and paired adjacent nontumor tissues were employed for the construction of 4 tissue microarrays (TMAs). The quality of the 4 TMAs was examined by HE staining. We performed immunohistochemistry analysis to evaluate hENT1 expression in the TMAs. Moreover, we detected hENT1 expression level and proved the role of hENT1 …

Mouse Models Of Chronic Lymphocytic Leukemia And Richter Transformation: What We Have Learnt And What We Are Missing, Maria Teresa Sabrina Bertilaccio, Shih-Shih Chen

Faculty, Staff and Student Publications

Although the chronic lymphocytic leukemia (CLL) treatment landscape has changed dramatically, unmet clinical needs are emerging, as CLL in many patients does not respond, becomes resistant to treatment, relapses during treatment, or transforms into Richter. In the majority of cases, transformation evolves the original leukemia clone into a diffuse large B-cell lymphoma (DLBCL). Richter transformation (RT) represents a dreadful clinical challenge with limited therapeutic opportunities and scarce preclinical tools. CLL cells are well known to highly depend on survival signals provided by the tumor microenvironment (TME). These signals enhance the frequency of immunosuppressive cells with protumor function, including regulatory CD4

A Relay Velocity Model Infers Cell-Dependent Rna Velocity, Shengyu Li, Pengzhi Zhang, Weiqing Chen, Lingqun Ye, Kristopher W Brannan, Nhat-Tu Le, Jun-Ichi Abe, John P Cooke, Guangyu Wang

Faculty, Staff and Student Publications

RNA velocity provides an approach for inferring cellular state transitions from single-cell RNA sequencing (scRNA-seq) data. Conventional RNA velocity models infer universal kinetics from all cells in an scRNA-seq experiment, resulting in unpredictable performance in experiments with multi-stage and/or multi-lineage transition of cell states where the assumption of the same kinetic rates for all cells no longer holds. Here we present cellDancer, a scalable deep neural network that locally infers velocity for each cell from its neighbors and then relays a series of local velocities to provide single-cell resolution inference of velocity kinetics. In the simulation benchmark, cellDancer shows robust …

Fc Gamma Receptors Promote Antibody-Induced Lilrb4 Internalization And Immune Regulation Of Monocytic Aml, Joshua W Morse, Xun Gui, Mi Deng, Ryan Huang, Xiaohua Ye, Peng Zhao, Xuejun Fan, Wei Xiong, Chengcheng Zhang, Ningyan Zhang, Zhiqiang An

Faculty, Staff and Student Publications

The immune checkpoint leukocyte immunoglobulin-like receptor B4 (LILRB4) is found specifically on the cell surface of acute monocytic leukemia (monocytic AML), an aggressive and common subtype of AML. We have developed a humanized monoclonal IgG1 LILRB4-blocking antibody (h128-3), which improved immune regulation but reduced cell surface expression of LILRB4 in monocytic AML models by 40–60%. Interestingly, most of this effect was neutralized by mutation of the Fc region of the antibody (h128-3/N297A), which prevents interaction with Fc gamma receptors (FcγRs). This suggested that there is FcγR-dependent antigenic modulation underlying h128-3’s effects, a mechanism known to alter the function of antibodies …

Neuromuscular Polytrauma Pain Is Resolved By Macrophage Cox-2 Nanoimmunomodulation, Ibdanelo Cortez, Caitlyn M Gaffney, Riddhi Vichare, Caitlin V Crelli, Lu Liu, Eric Lee, Jules Edralin, James M Nichols, Hoang Vu Pham, Syed Mehdi, Jelena M Janjic, Andrew J Shepherd

Faculty, Staff and Student Publications

Soft tissue injuries often involve muscle and peripheral nerves and are qualitatively distinct from single-tissue injuries. Prior research suggests that damaged innervation compromises wound healing. To test this in a traumatic injury context, we developed a novel mouse model of nerve and lower limb polytrauma, which features greater pain hypersensitivity and more sustained macrophage infiltration than either injury in isolation. We also show that macrophages are crucial mediators of pain hypersensitivity in this model by delivering macrophage-targeted nanoemulsions laden with the cyclooxygenase-2 (COX-2) inhibitor celecoxib. This treatment was more effective in males than females, and more effective when delivered 3 …

Candidate Circulating Microrna Biomarkers In Dogs With Chronic Pancreatitis, Susan K Armstrong, Robert W Hunter, Wilna Oosthyuzen, Maciej Parys, Adam G Gow, Silke Salavati Schmitz, James W Dear, Richard J Mellanby

Faculty, Staff and Student Publications

BACKGROUND: Pancreatitis is an important cause of disease and death in dogs. Available circulating biomarkers are not sufficiently sensitive and specific for a definitive diagnosis.

HYPOTHESIS: Circulating microRNAs would be differentially expressed in dogs with chronic pancreatitis and could have potential as diagnostic biomarkers.

ANIMALS: Healthy controls (n = 19) and dogs with naturally occurring pancreatitis (n = 17).

METHODS: A retrospective case-control study. Dogs with pancreatitis were included if they satisfied diagnostic criteria for pancreatitis as adjudicated by 3 experts. MicroRNA was extracted from stored serum samples and sequenced. Reads were mapped to mature microRNA sequences in the canine, …

Phospholipid Metabolic Adaptation Promotes Survival Of Idh2 Mutant Acute Myeloid Leukemia Cells, Tatsuya Morishima, Koichi Takahashi, Desmond Wai Loon Chin, Yuxin Wang, Kenji Tokunaga, Yuichiro Arima, Masao Matsuoka, Toshio Suda, Hitoshi Takizawa

Faculty, Staff and Student Publications

Genetic mutations in the isocitrate dehydrogenase (IDH) gene that result in a pathological enzymatic activity to produce oncometabolite have been detected in acute myeloid leukemia (AML) patients. While specific inhibitors that target mutant IDH enzymes and normalize intracellular oncometabolite level have been developed, refractoriness and resistance has been reported. Since acquisition of pathological enzymatic activity is accompanied by the abrogation of the crucial WT IDH enzymatic activity in IDH mutant cells, aberrant metabolism in IDH mutant cells can potentially persist even after the normalization of intracellular oncometabolite level. Comparisons of isogenic AML cell lines with and without IDH2 gene mutations …

Targeting The Renin-Angiotensin System (Ras) For Neuropsychiatric Disorders, Aline Silva De Miranda, Danielle S Macedo, Natalia P Rocha, Antonio L Teixeira

Faculty, Staff and Student Publications

BACKGROUND: Neuropsychiatric disorders, such as mood disorders, schizophrenia, and Alzheimer's disease (AD) and related dementias, are associated to significant morbidity and mortality worldwide. The pathophysiological mechanisms of neuropsychiatric disorders remain to be fully elucidated, which has hampered the development of effective therapies. The Renin Angiotensin System (RAS) is classically viewed as a key regulator of cardiovascular and renal homeostasis. The discovery that RAS components are expressed in the brain pointed out a potential role for this system in central nervous system (CNS) pathologies. The understanding of RAS involvement in the pathogenesis of neuropsychiatric disorders may contribute to identifying novel therapeutic …