Digital Commons Network^™

Fabrication And Validation Of Sub-Cellular Carbon Fiber Electrodes, Yu Huan, Hillel J. Chiel

Faculty Scholarship

Multielectrode arrays for interfacing with neurons are of great interest for a wide range of medical applications. However, current electrodes cause damage over time. Ultra small carbon fibers help to address issues but controlling the electrode site geometry is difficult. Here we propose a methodology to create small, pointed fiber electrodes (SPFe). We compare the SPFe to previously made blowtorched fibers in characterization. The SPFe result in small site sizes (105.4 ± 20.8μm²) with consistently sharp points (20.8 ± 7.64°). Additionally, these electrodes were able to record and/or stimulate neurons multiple animal models including rat cortex, mouse retina, …

The Flora, Fauna, And Paleoenvironment Of The Late Middle Miocene Quebrada Honda Basin, Bolivia (Eastern Cordillera, Central Andes), Beverly Z. Saylor, Russell K. Engelman, Darin A. Croft

Faculty Scholarship

Miocene ecosystem change in the Central Andes is not well understood because of a dearth of well-dated fossil sites from the region. The late Middle Miocene (~13-12 Ma) Quebrada Honda Basin (QHB) in southern Bolivia (22° S) helps fill this gap and provide vital insights into Neotropical paleoenvironments. The site is among the best-characterized Middle Miocene terrestrial vertebrate sites of South America and has a robust temporal, spatial, and lithostratigraphic framework for analyzing its sedimentary facies, fossils, and paleoenvironment. Here, we present new plant silica (phytolith) assemblage data from the QHB as well as new analyses of QHB faunal data. …

Amazonia In Motion: Changing Politics, Development Strategies, Peoples, Landscapes And Livelihoods, Susanna Hecht, Marianne Schmink, Rebecca Neaera Abers, Eduardo Assad, Denise Bebbington, Eduardo Brodizio, Francisco De Assis Costa, Ana María Calisto Durán, Philip Fearnside, Rachael Garrett, Sebastian Heilpern, David Mcgrath, Gustavo Oliveira, Henrique Pereira, Miguel Pinedo-Vazquez

Geography

We review the often-invisible powerful processes that drive social and ecological change in Amazonia, and the diverse peoples who inhabit its landscapes. It explores large-scale development ideologies of modernization, and the policy tools that were deployed to carry them out. Outlining general periods of macro policy shifts, we show the evolution of the framework for today’s complex interactions between large-scale agroindustry, mining, and hydrocarbons, and diverse small-scale livelihoods, as well as the clandestine and illicit economies of land grabbing, gold, coca and timber, and their operation in globalized and regional economies. While Pan-Amazonian governments have oscillated between authoritarian and democratic …

The Need For More Inclusive Deliberation On Ethics And Governance In Agricultural And Food Biotechnology, Catherine Kendig, Theresa Selfa, Paul B. Thompson, Raymond Anthony, Wenda Bauchspies, Gwendolyn Blue, Ashmita Das, Rebecca Harrison, Chris Henke, Shan Jin, Jennifer Kuzma, Forbes Lipschitz, Kurt Lichter, Morgan Ruelle, Timothy Silberg, Bruno Takahashi

Sustainability and Social Justice

An inclusive and socially legitimate governance structure is absent to address concerns over new agricultural biotechnologies. Establishing an agricultural bioethics commission devoted to inclusive deliberation on ethics and governance in agricultural and food biotechnology is urgent. Highlighting the social and ethical dimensions of current agricultural bioengineering disputes in the food system, we discuss how a nationally recognized policy forum could improve decision-making and increase public understanding of the issues. We clarify ways the concepts that are used to categorize food and frame governance of food affect consumer choices, and how dissemination of information and the mode of dissemination can contribute …

Exploring Angiotensin Ii And Oxidative Stress In Radiation-Induced Cataract Formation: Potential For Therapeutic Intervention, Vidya P. Kumar, Yali Kong, Riana Dolland, Sandra R. Brown, Kan Wang, Damian Dolland, David Mu, Milton L. Brown

Department of Biomedical and Translational Sciences Faculty Publications

Radiation-induced cataracts (RICs) represent a significant public health challenge, particularly impacting individuals exposed to ionizing radiation (IR) through medical treatments, occupational settings, and environmental factors. Effective therapeutic strategies require a deep understanding of the mechanisms underlying RIC formation (RICF). This study investigates the roles of angiotensin II (Ang II) and oxidative stress in RIC development, with a focus on their combined effects on lens transparency and cellular function. Key mechanisms include the generation of reactive oxygen species (ROS) and oxidative damage to lens proteins and lipids, as well as the impact of Ang II on inflammatory responses and cellular apoptosis. …

Social Media Sanctuaries: A Discourse Analysis Of Indian International Students' Agency And Liminality During The Russian-Ukrainian Conflict, Bhavika Sicka, Nadiya Ungo, Dennis Gregory

Educational Leadership & Workforce Development Faculty Publications

This study used a social media discourse analysis approach to illuminate the narratives of Indian international students in Ukraine who experienced displacement and upheaval because of the Russo-Ukrainian war. We used agency and liminality as analytic lenses to highlight how this uniquely situated population used Facebook to navigate conflict, voice their demands, support each other, challenge hegemonic narratives, re/construct their diasporic identities, and re-orient their futures. Findings indicate that Indian international students in Ukraine displayed insurmountable courage and resilience during the war, enacting agency from the margins to amplify their voices and actuate desired futures. Furthermore, South Asian students in …

Global South Sisterhood In Virtual Exchange: A Critical Autoethnography, Bhavika Sicka, Arzu Atajanova

Educational Leadership & Workforce Development Faculty Publications

We are two women international students from the Global South, situated in Turkey and the U.S. respectively. In this article, we utilized collaborative autoethnography to critically reflect on our intellectual, emotional, linguistic, and cultural growth during a virtual exchange program that we participated in during the COVID-19 pandemic. Through this co-exploration, we analyzed our experiences and reflections as participants in a COIL program to consider, more broadly, the evolution and trajectory of virtual mobility in an uneven higher education landscape. Our virtual exchange emerged as a digital and transnational third space, unbounded by hegemonic epistemic, linguistic, or geographical borders. We …

Between The Entrepreneurial Impetus For Higher Profits And Consumer Rights Or Types Of Unfair And Misleading Commercial Practices: Insights From Bulgaria, Silviya Atanasova Topleva

International Journal on Consumer Law and Practice

The application of unfair misleading commercial practices affects the economic interests of consumers, threatening legal security and the achievement of market equilibrium. In response to these imbalances, the law builds a solid regulatory network for consumer protection. In the codification of the protection of consumer interests from unfair commercial practices, an important place is occupied by secondary legislation of the EU, and in particular Directive 2005/29/EC concerning unfair business-to-consumer commercial practices in the internal market. The article presents a classification of the types of unfair misleading commercial practices based on the regulatory framework at the European and national level. The …

Pa(Th)S (2024), Alejandra Espada Revuelto

Grado en Diseño de Moda

El ritmo frenético impuesto por el sistema capitalista y la consecuente sobreestimulación de los individuos conforma una creciente problemática a nivel físico y psicológico debido al empobrecimiento de nuestra relación con nosotros mismos en un estado de calma y, por ende, con el medio natural. Uno de los objetivos principales de este estudio es evaluar los efectos de una continuada exposición a estímulos de procedencia externa e interna en Personas Altamente Sensibles y la relación entre esto y la progresiva desnaturalización del ser humano en la mayoría de sociedades actuales. Se ha llevado a cabo un análisis exhaustivo de escritos …

Forum: The Russia–Ukraine War And Reactions From The Global South, Vidya Nadkarni, Paul D’Anieri, S. A. Kerr, Gulnaz Sharafutdinova, Xiaoyu Pu, Deepa M. Ollapally, Paulo Velasco, Candice Moore, Abdolrasool Divsallar

Political Science and International Relations Faculty Publications

The war between Russia and Ukraine has been a topic of interest for scholars and policymakers worldwide. Western countries have condemned and imposed sanctions on Russia, while countries in the Global South have taken varying positions. In this Forum, we will analyse the origins of the war and the responses to it of key countries in the Global South, including China, India, Brazil, South Africa, and Iran. The war has multiple causes, and identifying them has implications for understanding what is necessary to regain peace. However, reaching a consensus on its causes will not be easy. Great and middle powers …

Mechanistic Approach To Understanding Adverse Liver Outcomes Related To Pfas Exposure In Neonatal And Adult Mice, Emily Kaye

Open Access Dissertations

Per- and polyfluoroalkyl substances (PFAS) are a unique class of over 15,000 manmade chemicals that are still widely used in manufacturing and are resistant to degradation. Accumulation in the environment and general population has been associated with an array of adverse health outcomes. Perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), and perfluorohexanesulfonic acid (PFHxS) specifically have been associated with markers of liver injury, high serum cholesterol, thyroid disease, low fetal birth weight, suppressed vaccine response, and cancer. Exposure to PFAS is commonly investigated individually, however, humans are exposed to a multitude of PFAS daily. Additionally, with the pervasive nature of these …

Effects Of Western Diet Or Exercise Exposure In A Novel Rat Model Of Late-Onset Alzheimer’S Disease, Jennifer M. Mattar

Open Access Dissertations

Sporadic, late-onset Alzheimer’s disease (LOAD) accounts for a staggering 98% of cases yet does not arise from a single genetic mutation. Rather, an extensive body of research has revealed that LOAD is likely the result of complex interactions between genetics and several lifestyle factors. There exists a substantial gap in understanding the mechanisms behind LOAD development and the impacts of lifestyle on disease progression. Enhanced rodent models may help elucidate mechanisms by which LOAD develops. This longitudinal study introduces a novel rat model of LOAD (CrAβ), created using CRISPR-Cas9 gene editing technology to express humanized Aβ. The effects of a …

Design And Application Of Ph Sensitive Peptides For Fluorescence Imaging And Therapy Of Tumors, Michael Dupont

Open Access Dissertations

The most common cancer treatments are chemotherapy and radiation therapy which include an untargeted delivery of toxic molecules, resulting in systemic effects and reduction in patient comfort. This leads to research for cancer treatments that are targeted and will reduce the severity of systemic effects on patients. Tumor resection surgery also has its own complications relating to not having real time confirmation of tumor geometry and position. pHLIP peptide targets acidity which is a characteristic of most cancer lines due to the Warburg effect, along with targeting tumor associated macrophages, cancer associated fibroblasts, and myeloid derives suppresser cells that are …

Developing Effective Physical And Chemical Adjuvants For Influenza And Tumor Vaccines, Yibo Li

Open Access Dissertations

An adjuvant is a pharmacological substance added to a vaccine to enhance the intensity, breadth and endurance of the immune responses. Traditional discovery and development of vaccine adjuvants mainly based on empirical experiences have been slow, but the situation has improved in the past two decades as more molecular mechanisms of vaccine adjuvants were revealed. Now it has been widely recognized that most adjuvants activate innate immune system by targeting pattern recognition receptors (PRRs) such as toll-like receptors (TLRs) to enhance adaptive immune responses. PRRs are proteins expressed mainly on innate immune cells, such as dendritic cells (DCs) and macrophages, …

From Woke-Washing To Authentic Brand Activism: Essays On Its Impact On Consumer Identity, Brand Morality And Brand Responses, Priscilla Yamilet Peña

Open Access Dissertations

Brand activism, in which a brand publicly takes a political or social justice stance, has gained momentum, positioning brands as agents of societal change. However, accusations of inauthentic brand activism or "woke washing" present a significant challenge. Understanding the basis for these accusations and their effects on consumer identity, particularly among stigmatized groups, requires further exploration. This dissertation aims to shed light on consumers' perspectives of inauthentic brand activism and proposes effective brand messaging strategies. The first manuscript explores consumer accusations of woke-washing using the Zaltman Metaphor Elicitation Technique (ZMET), uncovering emerging themes, and assessing the damage to identity within …

Design, Simulation, And Rapid Prototyping Of Soft Robotic Actuators For Deep-Sea Applications, Alexander Yin

Open Access Dissertations

A new design and rapid prototyping approach for hydraulic soft actuators was developed and used to create bio-inspired underwater soft actuators that were tested and applied in the field. Underwater soft-bodied animals demonstrate complex approaches to move around the ocean and sophisticated methods of physically interacting with other organism and objects. Studying the functional design and kinematics of these animals can provide insight and solutions for complex tasks and locomotion, and soft robotics provides pathways to create complex actuators that imitate or are inspired by these animals. However, creating a complex soft actuator is currently an arduous and time-consuming process …

Mechanistic And Toxicokinetic Analysis Of Perfluoroalkyl Substances: Proteomics Approach And The Role Of Fatty Acid Binding (Fabp), Seyed Mohamad Sadegh Modaresi

Open Access Dissertations

Per- and polyfluoroalkyl substances (PFAS) are persistent chemicals used in many industries, known for their resilience and resistance to degradation. The extended half-lives of PFAS in the human body result in bioaccumulation, with serum half-lives for perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexane sulfonic acid (PFHxS) estimated at 3.4, 4.6, and 7.1 years, respectively. PFAS primarily accumulate in the liver, hypothesized due to their resemblance to fatty acids and their binding with liver fatty acid-binding proteins (LFABP), affecting lipid metabolism and leading to liver toxicity. Although extensive research has been performed on long-chain PFAS over the past decade, …

Strategies To Stress Less: A Meta-Analytic Review Of The Effects Of Mindfulness-Based Stress Reduction (Mbsr) On Self-Reported Stress, Gregory J. Champion

Open Access Dissertations

Introduction: Stress negatively impacts health, well-being, and productivity. Mindfulness-based stress reduction (MBSR) interventions are a promising strategy to reduce stress, but they are not covered by most health insurance policies in the United States (US). A recent Delphi process gathered feedback from key stakeholders, such as clinicians, MBSR instructors and students, policymakers, healthcare administrators, and health insurance company leaders. The results indicated synthesizing the existing evidence of the impact of MBSR interventions on stress was the 2nd highest priority out of 43 options evaluated. Past research has indicated MBSR interventions may be as effective as active controls at reducing …

Treading Carefully In The Deep Ocean: Insights Into The Effects Of Artificial Light And Sound From Robotic Platforms On Pelagic Animal Surveys Using Active Acoustics And Low-Light Imaging Techniques, Rendhy Moreno Sapiie

Open Access Dissertations

Science and technology are coupled disciplines. Breakthroughs in ocean science are often pertinent to the ability to observe physical, chemical, and biological processes at the right temporal and spatial scales, which typically involves the use of robots. Large, powerful, and extremely capable, the scientific work-class remotely operated vehicle (ROV) is the golden standard when observing fine temporal scale intricate processes in the full ocean stratum and has unraveled important discoveries in deep-sea biology and ecology. Sound, light, and hydrodynamic forces produced from these vehicles are sources of disturbances that may impact quantitative observations in the twilight zone, an environment absent …

Nanotube Spectral Fingerprinting And Machine Learning For Optimized Bioimaging/Sensing Applications, Aceer Nadeem

Open Access Dissertations

This thesis presents a multifaceted exploration of the optimization and application of single-walled carbon nanotubes (SWCNTs) in biomedical contexts, with a specific focus on enhancing their stability, functionality, and use as optical biosensors. The research spans several key areas, including the development of innovative techniques that couple machine learning with spectral fingerprinting for advanced diagnostics, the investigation of SWCNT chirality and its implications for cellular interactions, and the optimization of lyophilization processes to improve long-term stability and reproducibility.

The first section of the thesis delves into the fundamental properties of SWCNTs, emphasizing their unique electronic and optical characteristics. These properties, …

From Page To Stage: Enlightenment Common Sense & The Semiotics Of The Body, 1660–1820, Nilton X. Gomes

Open Access Dissertations

How did eighteenth-century audience members or novel readers come to see beyond the facades of literary characters and narrators? By looking into moments of bodily concealment in the eighteenth-century novel and theater, this dissertation examines how authors and playwrights in this period wrote with subtly and force to make the body as and in many instances more legible to their readers as the words on the page or the dialogues on the stage in attempts to suture the gap that lies between what a writer intends and what a reader grasps in a literary work. It also stresses the body’s …

The Distribution And Habitat Use Of Semi-Aquatic Mammals In A Changing New England Landscape, Josh Crockett

Open Access Dissertations

Semi-aquatic mammals (i.e., animals that depend on both terrestrial and aquatic environments for their daily needs) are an ecologically and economically important group, but they are often difficult to monitor because of their restricted habitat which makes them unlikely to appear in monitoring schemes designed for all mammals (e.g., camera trapping). Rhode Island is home to several semi-aquatic mammal species, including North American beavers (Castor canadensis), North American river otters (Lontra candensis), and muskrats (Ondatra zibethicus). Historically, these species were all exploited for their furs, which led to drastic declines in otter and (especially) …

Telechelic Polymers As High-Performance Rheological Modifiers In Biomimetic Polymer-Linked Emulsions, Daniel P. Keane

Open Access Dissertations

Due to the complexity of biological tissue and the numerous challenges associated with research into biological particle transport, it is of interest to scientists to develop a synthetic mimic that can replicate key attributes of multicellular tissue. The work presented in this dissertation details the design, characterization, and application of a synthetic material for use as a phantom material in research into biological particle transport. Furthermore, the designed materials introduce exciting polymer physics problems and present broad potential uses as rheological modifiers for colloidal systems and 3D printing inks. The polymer-linked emulsions which form the basis of this work are …

Infringement Episodes, Shani Shisha

Faculty Journal Articles and Book Chapters

For decades, copyright scholars have waged a spirited campaign against statutory damages. Our remedial system, critics say, is an incoherent mess. The core problem is that copyright holders can recover a separate award of statutory damages for every infringed work. As a result, damages can rapidly add up in any case involving multiple works. Because the number of statutory awards is tethered to the number of works, even trivial claims can lead to crippling damages. Commentators, policymakers, and judges have criticized this system as arbitrary and overbroad. And yet it endures. This Article argues that copyright’s per-work scheme has obscured, …

Ifn-𝜸 And Il-10 Immunosensor With Vertically Aligned Carbon Nanotube Interdigitated Electrodes Toward Pen-Side Cattle Paratuberculosis Monitoring, Shaowei Ding, Benjamin J. Brownlee, Kshama Parate, Cicero C. Pola, Bolin Chen, Jesse M. Hostetter, Douglas Jones, John Jackman, Brian D. Iverson, Jonathan C. Claussen

Faculty Publications

Highly sensitive vertically aligned carbon nanotube arrays (VANTAs) interdigitated electrode (IDE) arrays are developed for electrochemical biosensing of two cytokines (i.e., interleukin-10 (IL-10) and interferon-gamma (IFN-𝜸)) that are useful for early detection Johne’s disease (Bovine Paratuberculosis) in cattle. The high aspect ratio VANTA-IDEs (50–60 μm in height) are grown through a chemical vapor deposition process from an iron (Fe) catalyst that is lithographically patterned on a silicon wafer with equal finger width and inter-finger spacing of 25 μm. After functionalization with distinct antibodies the VANTA-IDEs are capable of selective detection of both IL-10 and IFN-𝜸 within an actual biological matrix …

Biophilic Design And Biophilic Cities: An Explainer, Kincaid Brown

Law Librarian Scholarship

The COVID-19 pandemic brought into focus that outdoor activities in natural settings have a positive impact on mental health, and individuals participating in outdoor activity report higher rates of emotional well-being than individuals who do not participate in such activity. Biophilic design is an architectural practice that aims to connect people to nature through design concepts with one of the benefits being psychological. Other benefits of biophilic design include improvements to environmental quality, physical health, support of animal species and habitats, and more resilient and energy-efficient cities.

The Neurochemistry Of Depression: The Good, The Bad And The Ugly, Kami Pearson, Kimberley Beier, Thornton Mardis, Bryan Munoz, Asma Zaidi

Faculty and Staff Publications

A large constellation of experimental evidence suggests that neuroinflammation is involved in the onset of depression and neurodegenerative disorders. Many studies have shown impairments in tryptophan metabolism, the major pathway for the synthesis of serotonin, the mood regulating neurotransmitter. This article reviews the various metabolites generated in the competing pathways of tryptophan metabolism including the kynurenine pathway. Increased synthesis of the neurotoxic compound quinolinic acid occurs at the expense of the synthesis of the neuroprotective metabolite kynurenic acid. This shift in equilibrium plays a critical role in the induction of oxidative stress, neuroinflammation, and neurotoxicity. Sufficient protein intake with adequate …

What Fischer V. United States Gets Wrong About Prosecutorial Discretion, Cindy J. Cho

Articles by Maurer Faculty

Conservative Supreme Court Justices have recently expressed heightened concerns about prosecutorial power in cases involving former President Donald Trump and the Capitol siege on January 6, 2021.  Making good on those worries, the conservative majority in Fischer v. United States, rested its decision in part on theoretical concerns about government overreach. The Department of Justice has pushed back on those concerns, but to this point, the debate has been mostly rhetorical and hypothetical.

This article attempts to fill that rhetorical void—and concretely answer the concerns animating Fischer—with evidence from actual cases.  A survey of ten January 6 cases …

Through Smoke And Mirrors: Excluding Malingering Expert Testimony Under The Daubert Standard, Chunlin Leonhard, Christoph Leonhard

Georgia Law Review

Because of science’s claim to objectivity, scientific testimony is persuasive and often outcome-determinative. Our adversarial system incentivizes litigants to proffer scientific evidence to support their positions. The task falls on trial judges as gatekeepers to distinguish valid scientific evidence from junk science. Drawing this line is difficult because scientific evidence covers a broad spectrum. The United States Supreme Court has set forth the standard of admissibility of scientific evidence in Daubert and its progeny (the Daubert Standard). Trial judges are supposed to admit scientific evidence only if reliable and relevant under the Daubert Standard. But three decades after Daubert, …

Exploring Long-Term Patterns: Black Bass Tournament Fishery And Population Trends In West Virginia's Navigable Rivers, Alex J. Benecke

Graduate Theses, Dissertations, and Problem Reports (ETD)

Black bass Micropterus spp. are popular sport fish in West Virginia’s navigable rivers. In recent years, anglers have expressed concerns about a potential decline in fishery quality. To investigate these claims, we evaluated whether fishery quality has declined compared to earlier periods and whether population trends correspond to angler catch rates. Specifically, we aimed to (1) examine changes in species catch over time and during key periods, such as tournament and spawning seasons; (2) describe the distribution of black bass species across pools and habitat types; and (3) assess the outcomes of previous stocking efforts. To address these objectives, we …