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Synthesis Of Yaku'amide A Analogues And Progress Toward Synthesis Of Virosine A, Alexander S. Ramos

Theses and Dissertations

The first project in this dissertation endeavors to outline the total synthesis of yaku'amide A and its analogs. Yaku'amide A is a natural product comprised of dehydroamino acids, including E-dehydro isoleucine, and unprecedented Z-dehydro isoleucine. These amino acids present a significant challenge to their synthesis owing to their unsymmetrical nature. To simplify the synthesis process, we synthesized analogs by substituting the E and Z dehydroamino acids with symmetrical subunits. This substitution facilitated the synthesis process and enabled us to obtain a similar three-dimensional structure to that of the natural product. Furthermore, biological testing of the simplified analogs revealed potency similar …

Myocardial Protection In High-Risk Cardiopulmonary Bypass Support, Subhasis Chatterjee, Marc R. Moon

Journal of Shock and Hemodynamics

The development of cardioplegia has facilitated complex cardiac surgery and allowed high-risk patients to safely tolerate life-saving procedures. By following the principles of electromechanical arrest, inducing hypothermia, and using adjunctive agents to help mitigate the effects of hypothermia and ischemia reperfusion injury, cardioplegia can be safely induced with various commercially available compositions, which can be delivered by several different surgical techniques. Although many studies have compared these methods, there is little consensus on whether any one method is superior to another. Just as a surgeon may need to modify technique according to individual patient factors, so too must a surgeon …

Oregon State Rank Assessment For Yellow Bumblebee (Bombus Fervidus), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Yellow bumblebee (Bombus fervidus) using NatureServe methodology, 2023.

Ultrafast Electronic Relaxation Pathways Of The Molecular Photoswitch Quadricyclane, Kurtis D. Borne, Joseph C. Cooper, Michael N. R. Ashfold, Julien Bachmann, Surjendu Bhattacharyya, Rebecca Boll5, Matteo Bonanomi, Michael Bosch, Carlo Callegari, Martin Centurion, Marcello Coreno, Basile F. E. Curchod, Miltcho B. Danailov, Alexander Demidovich, Michele Di Fraia, Benjamin Erk, Davide Faccialà, Raimund Feifel, Ruaridh J. G. Forbes, Christopher S. Hansen, David M. P. Holland, Rebecca A. Ingle, Roland Lindh, Lingyu Ma, Henry G. Mcghee, Sri Bhavya Muvva, Joao Pedro Figueira Nunes, Asami Odate, Shashank Pathak, Oksana Plekan, Kevin C. Prince, Primoz Rebernik, Arnaud Rouzée, Artem Rudenko, Alberto Simoncig, Richard J. Squibb, Anbu Selvam Venkatachalam, Caterina Vozzi, Peter M. Weber, Adam Kirrander, Daniel Rolles

Martin Centurion Publications

The light-induced ultrafast switching between molecular isomers norbornadiene and quadricyclane can reversibly store and release a substantial amount of chemical energy. Prior work observed signatures of ultrafast molecular dynamics in both isomers upon ultraviolet excitation but could not follow the electronic relaxation all the way back to the ground state experimentally. Here we study the electronic relaxation of quadricyclane after exciting in the ultraviolet (201 nanometres) using time-resolved gas-phase extreme ultraviolet photoelectron spectroscopy combined with non-adiabatic molecular dynamics simulations. We identify two competing pathways by which electronically excited quadricyclane molecules relax to the electronic ground state. The fast pathway (<100 femtoseconds) is distinguished by effective coupling to valence electronic states, while the slow pathway involves initial motions across Rydberg states and takes several hundred femtoseconds. Both pathways facilitate interconversion between the two isomers, albeit on different timescales, and we predict that the branching ratio of norbornadiene/ quadricyclane products immediately after returning to the electronic ground state is approximately 3:2.

Ndls Communicator: Week Of 12.11.23, Notre Dame Law School

NDLS Communicator

The Latest News

• Derek Muller was interviewed and quoted in several news articles last week.
• Nicole Garnett was quoted in a Deseret News article, "Of church and state."
• Lawrence Solum of the Legal Theory Blog selected Stephanie Barclay's new article, "Replacing Smith," for the Download of the Week.
• Patrick Corrigan will be speaking on December 12 at the ACLE Seminar at the University of Amsterdam on "The Prisoner's Dilemma of Stockholders in Social Enterprises."
• Bruce Huber recently did an hour-long interview about climate change on the Good Faith podcast.
• Lisa Koop was one of the immigration lawyers interviewed in this …

Humankind – Bias In Our Head, Luying Li

Theses

"HumanKind" is a dynamic exploration at the intersection of visual communication design and societal awareness, seeking to unravel and mitigate the far-reaching impacts of bias. Through the fusion of "Human" and "Kind," the project embodies a dual narrative, emphasizing individual humanity and the diverse fabric of the human collective. The core inquiry revolves around encouraging individuals to recognize and challenge biases before decision-making, fostering unbiased choices. Historical narratives of racial conflicts serve as the foundation, propelling the project's mission to explore, challenge, and diminish biases entrenched in our collective consciousness. Going beyond traditional exhibitions, "HumanKind" evolves into a dynamic dialogue …

Cookool: A Futuristic Cooking Innovation, Guannan Ling

Theses

Cookool is a futuristic innovation project that utilizes real-time interactive design and technology to display cooking information seamlessly, aiming to create a cool, friendly, and relaxed cooking experience for everyone to try, learn, and fall in love with. In traditional kitchens, people often face various challenges such as choosing dishes and controlling temperatures. However, in the future, our kitchen will leverage AI technology to precisely recommend dishes based on personal preferences, utilize thermal detection to monitor utensil temperatures, and leverage hologram and AR technology to showcase recipes and cooking processes, making cooking simpler. Yet, technology alone cannot create an inclusive …

Bikram Singh V. Doris Hawkins

All Decisions

The tenant moved to dismiss a holdover proceeding brought by their landlord. The landlord had sought to evict her after accepting funds from the COVID-19 emergency rental assistance program (ERAP) and then terminating her tenancy. The tenant argued that the ERAP statute barred the landlord from terminating her tenancy within one year of accepting the funds. The court agreed with the tenant and dismissed the proceeding.Key Legal Points:Accepting ERAP funds prevents a landlord from terminating a tenancy for one year, even if the eviction proceeding is not filed until after the year is up.Landlords cannot evict tenants for non-payment of …

Engineering Exosomes To Specifically Target The Mitochondria Of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi

Michigan Tech Publications

Mitochondrial dysfunction is associated with various health conditions, including cardiovascular and neurodegenerative diseases. Mitochondrial-targeting therapy aims to restore or enhance mitochondrial function to treat or alleviate these conditions. Exosomes, small vesicles that cells secrete, containing a variety of biomolecules, are critical in cell-to-cell communication and have been studied as potential therapeutic agents. Exosome-based therapy has the potential to treat both cardiovascular and neurodegenerative diseases. Combining these two approaches involves using exosomes as carriers to transport mitochondrial-targeting agents to dysfunctional or damaged mitochondria within target cells. This article presents a new technique for engineering brain-derived exosomes that target mitochondria and has …

Roads To Removal Charts Path To Net-Zero Greenhouse Gas Economy, Robbin Ray

UNH Today Archive

No abstract provided.

Impact Of Irrigation On Vulnerability Of Winter Wheat Under Extreme Climate Change Scenario: A Case Study Of North China Plain, Yulian Gao, Lin Wang, Yaojie Yue

Department of Agricultural and Biological Systems Engineering: Faculty Publications

An inadequate understanding of the impacts of adaptation countermeasures tends to exaggerate the adverse e􀀀ects of climate change on agricultural systems. Motivated by proposing reasonable climate change adaptation countermeasures, the present study applied the EPIC model to quantify the impacts of climate change and irrigation changes with future socioeconomic development on agricultural production. Winter wheat yield losses using dynamic irrigation parameters in the North China Plain (NCP) from 2010 to 2099 under a scenario coupling climate change and future socioeconomic development (RCP8.5-SSP3), and those under an extreme climate change scenario (RCP8.5), were simulated. Results show that EPIC model demonstrates superior …

Learning From Women Veterans Who Navigate Invisible Injuries, Caregiving, And Reintegration Challenges, Nicholas A. Rattray, Diana Natividad, Katrina Spontak, Marina Kukla, Ai Nghia L. Do, Leah Danson, Richard M. Frankel, Gala True

School of Medicine Faculty Publications

Background: As women comprise a greater proportion of military service members, there is growing recognition of how their experiences in the early phase of military to civilian transitions have an important influence on their health and reintegration outcomes. Qualitative accounts of women veterans can inform programs that support transitioning service members. Objectives: We examined narratives of civilian reintegration among women veterans to understand their experiences of adjusting to community life while coping with mental health challenges. Methods/Participants: We interviewed 16 post-911 era women who were within 5 years of separating from military service and developed a case study based on …

Oregon State Ranking Assessment For Morrison Bumblebee (Bombus Morrisoni), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Morrison bumblebee (Bombus morrisoni) using NatureServe methodology, 2023.

Contextualizing Singlehood Among Young Adults: Exploring The Meanings And Perceived Reasons For Being Single, Jonathon J. Beckmeyer, Tyler B. Jamison

Faculty Publications

Objective: We explored how young adults discussed their experiences with singlehood and their reasons for being single.

Background: Despite singlehood being normative during young adulthood, less research has focused on the diversity of singlehood compared to that of romantic involvement.

Method: In Study 1, 35 young adults participated in in-depth qualitative interviews about their romantic histories. We explored singlehood meanings and reasons in the context of their relationship histories. In Study 2 we used data from 155 single young adults to explore the factor structure, internal reliability, and initial validity of the Reasons for Being Single (RBS) scale, which we …

State Of Utah, Plaintiff/Appellee, V. Thomas Jacob Walker, Defendant/Appellant : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

This is an appeal from the sentence, judgment and commitment from a bench trial filed the 7th day of April, 2023 in the Fifth Judicial District Court of Iron County, State of Utah, the Honorable Ann Marie McIff Allen presiding. The Appellant was sentenced to serve a suspended jail term, ordering that he pay a fine of TWO HUNDRED AND FIFTY THREE ($253) DOLLARS including the sur charge. He was placed on probation for EIGHTEEN (18) MONTHS, ordered to obey all laws; complete FIFTY (50) hours of community service along with additional terms. This included having no contact of any …

Relationship Between Patient Satisfaction And Hospital Financial Performance Among U.S. Acute Care For-Profit Hospitals, Dione Dillard

Walden Dissertations and Doctoral Studies

No abstract provided.

Intouch Week Of December 11, 2023, New York Medical College

InTouch

• Key Discovery Could Offer Hope in Fight Against Alzheimer's Disease
• James Williams’ Journey from the NFL to NYMC
• Student Housing Fitness Center Gets a Makeover
• BioInc@NYMC Welcomes Marubeni America Specialty Chemicals Unit as Newest Client
• D.P.T. Class of 2025 Present Community Service Projects
• Student Spotlight: Kathleen Harwood Lead Authors Publications in Sports Medicine

Local Approaches To Address Global Challenges: Educating Local Innovators For Positive Social Change, Martha Leticia Silva-Flores, Melisa Ladrón De Guevara

Journal of Management for Global Sustainability

Aligning global concerns with local challenges is essential for achieving long-term sustainability. This entails addressing local communities’ needs and issues to develop effective and sustainable solutions. This approach not only benefits communities but also has the potential to impact the environment and society positively. Local innovators play a fundamental role in promoting sustainable development by devising creative and sustainable solutions to problems affecting their communities. However, in the case of local entrepreneurs in the Guadalajara Metropolitan Area (GMA), their ventures often have a fleeting lifespan, limiting their impact on global challenges. This research study, therefore, focuses on empowering these local …

Teaching Engineering Design-Based Integrated Stem In Rural Contexts: Nurturing Future Designers, Jung Han, Euisuk Sung, Todd Kelley, John Geoffrey Knowles

Publications and Research

There is a notable shift towards prioritizing the teaching of engineering design within K-12 education, coupled with a strong recommendation for engineering design-based integrated STEM education. This approach underscores the sharing of science and engineering practices as a means to facilitate the learning of various STEM disciplines. Nonetheless, the implementation of integrated STEM education in rural schools poses challenges due to constrained resources and a shortage of high-quality programs. To present a tangible instance of design-based integrated STEM education within a rural setting, this study presents a model lesson that showcases the integration of interdisciplinary problem-solving skills within a genuine …

The Advent Art Of Waiting, Noah Toly

University Faculty Publications and Creative Works

No abstract provided.

Establishing A Novel Lipid-Polyamine Metabolic Connection To Virus Replication, Yazmin Edith Cruz Pulido

Dissertations

Polyamines are small positively charged alkylamines found in all living cells. These ubiquitous molecules have been found to play a variety of roles ranging from stabilizing nucleic acids (DNA and RNA) to cellular proliferation. Studies have also identified roles for polyamines in viral packaging and viral enzyme function. However, the role of polyamines on cellular components and their effect on viral replication is less known. In our efforts to identify the lipid-polyamine metabolic connection to virus replication we utilized a human hepatocyte cell line in which polyamines were depleted via pharmacological or genetic approaches and studied the effects on lipid …

The Effect Of Reading Habits On Academic Success, Taylor Hicks

Masters Projects

The goal of most students is to achieve academic success. In order to be successful, students must form healthy reading habits because there is a positive correlation between academic success and reading habits. The more students read, the greater their chances of performing well academically. By participating in frequent reading, students will, not only perform well in school, they will also expand their vocabulary, improve their writing skills, and sharpen their critical thinking skills. We are in the midst of a literacy crisis, though. Students are choosing other avenues for entertainment instead of reading. This could potentially have detrimental consequences. …

An Analysis Of The Efficacy Of Disciplinary Methods, William Hewitt

Masters Projects

The practice of punitive discipline is the most common response to misbehavior in American school systems, despite having no evidence to support its continued use. However, there is research that demonstrates its active harm to students in multiple capacities. Punitive discipline has been found to only exacerbate students’ behavior issues, as well as negatively impact their academic performance. Additionally, research has pointed out that punitive discipline impacts students of minority demographics at a significantly higher rate than students belonging to majority demographics. More research in the way of alternative restorative policies, such as Positive Behavior Interventions and Supports (PBIS), is …

Metformin: A Potential Treatment For Acne, Hidradenitis Suppurativa And Rosacea, Minah Cho, Yu Ri Woo, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim

Faculty, Staff and Student Publications

Metformin is a widely used drug for treatment of diabetes mellitus, due to its safety and efficacy. In addition to its role as an antidiabetic drug, numerous beneficial effects of metformin have enabled its use in various diseases. Considering the anti-androgenic, anti-angiogenic, anti-fibrotic and antioxidant properties of metformin, it may have the potential to improve chronic inflammatory skin diseases. However, further evidence is needed to confirm the efficacy of metformin in dermatological conditions, This review focuses on exploring the therapeutic targets of metformin in acne vulgaris, hidradenitis suppurativa and rosacea, by studying their pathogeneses.

Review Of "Faith And Fake News: A Guide To Consuming Information Wisely", Katherine J. Graber

The Christian Librarian

No abstract provided.

Taxane-Based Chemotherapy Is Effective In Metastatic Appendiceal Adenocarcinoma, Julia Dansby, Aditya More, Mohammad Zeineddine, Abdelrahman Yousef, Alisha Bent, Farshid Dayyani, Robert Wolff, Michael Overman, John Paul Shen

Faculty, Staff and Student Publications

Appendiceal cancer is a rare, orphan disease with no therapies currently approved by the FDA for its treatment. Given the limited data regarding drug efficacy, these tumors have historically been treated with chemotherapy designed for colon cancer. However, an overwhelming body of molecular data has demonstrated that appendiceal adenocarcinoma is a distinct entity with key molecular differences from colon cancer, notably rare APC mutation. Recognizing that APC loss-of-function is thought to contribute to taxane resistance and that taxanes are effective in the treatment of other gastrointestinal tumors, including gastric, esophageal, and small bowel adenocarcinoma, we completed a single-center retrospective study …

Sustained Disease Control In Immune Checkpoint Blockade Responders With Microsatellite Instability-High Colorectal Cancer After Treatment Termination, Kristen Simmons, Jane V Thomas, Kaysia Ludford, Jason A Willis, Victoria S Higbie, Kanwal P S Raghav, Benny Johnson, Arvind Dasari, Bryan K Kee, Christine M Parseghian, Michael S Lee, Phat H Le, Maria P Morelli, John Paul Shen, Alisha Bent, Eduardo Vilar, Robert A Wolff, Scott Kopetz, Michael J Overman, Van Karlyle Morris

Faculty, Staff and Student Publications

Immune checkpoint inhibitors improve survival in patients with mismatch repair deficiency/microsatellite instability-high (MSI-H) colorectal cancer. The recurrence outcomes following discontinuation of immunotherapy after prolonged disease control have not been definitively reported in large series. Records from patients with advanced MSI-H colorectal cancer from The University of Texas - MD Anderson Cancer Center who received immunotherapy between 2014 and 2022 and stopped after prolonged clinical benefit were reviewed. Median progression-free and overall survival were estimated. Associations between the event of recurrence and coexisting mutations (KRAS/NRAS, BRAFV600E), metastatic organ involvement (lung, liver, lymph node, or peritoneum), metastatic timing (synchronous vs. metachronous), prior …

Spatiotemporal Genomic Profiling Of Intestinal Metaplasia Reveals Clonal Dynamics Of Gastric Cancer Progression, Kie Kyon Huang, Haoran Ma, Roxanne Hui Heng Chong, Tomoyuki Uchihara, Benedict Shi Xiang Lian, Feng Zhu, Taotao Sheng, Supriya Srivastava, Su Ting Tay, Raghav Sundar, Angie Lay Keng Tan, Xuewen Ong, Minghui Lee, Shamaine Wei Ting Ho, Tom Lesluyes, Hassan Ashktorab, Duane Smoot, Peter Van Loo, Joy Shijia Chua, Kalpana Ramnarayanan, Louis Ho Shing Lau, Takuji Gotoda, Hyun Soo Kim, Tiing Leong Ang, Christopher Khor, Jonathan Wei Jie Lee, Stephen Kin Kwok Tsao, Wei Lyn Yang, Ming Teh, Hyunsoo Chung, Jimmy Bok Yan So, Khay Guan Yeoh, Patrick Tan, Singapore Gastric Cancer Consortium

Faculty, Staff and Student Publications

Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 subjects from a prospective 10-year study, we identify 26 IM driver genes in diverse pathways including chromatin regulation (ARID1A) and intestinal homeostasis (SOX9). Single-cell and spatial profiles highlight changes in tissue ecology and IM lineage heterogeneity, including an intestinal stem-cell dominant cellular compartment linked to early malignancy. Expanded transcriptome profiling reveals expression-based molecular subtypes of IM associated with incomplete histology, antral/intestinal cell types, ARID1A mutations, inflammation, and microbial communities normally associated with the healthy …

Enlightenment Ideals And Belief In Progress In The Run-Up To The Industrial Revolution: A Textual Analysis, Ali Almelhem, Murat Iyigun, Austin Kennedy, Jared Rubin

ESI Working Papers

We trace the evolution of the language of science, religion, and political economy in the centuries leading to the British Industrial Revolution. Using textual analysis of 264,443 works printed in England between 1500 and 1900, we test whether British culture manifested a belief in progress associated with science and industry. Our analysis yields three main findings. First, there was a separation in the languages of science and religion beginning in the mid-18th century. Second, volumes using language at the nexus of science and political economy became more progress-oriented during the Enlightenment. Third, volumes using industrial language—especially those at the science-political …

Review Of "Another Gospel?: A Lifelong Christian Seeks Truth In Response To Progressive Christianity", Robert J. Oliverio

The Christian Librarian

No abstract provided.