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Articles 6451 - 6480 of 163201
Full-Text Articles in Entire DC Network
Nitric Oxide Is Required For Lung Alveolarization Revealed By Deficiency Of Argininosuccinate Lyase, Zixue Jin, Ming-Ming Jiang, Brendan Lee
Nitric Oxide Is Required For Lung Alveolarization Revealed By Deficiency Of Argininosuccinate Lyase, Zixue Jin, Ming-Ming Jiang, Brendan Lee
Faculty, Staff and Students Publications
Inhaled nitric oxide (NO) therapy has been reported to improve lung growth in premature newborns. However, the underlying mechanisms by which NO regulates lung development remain largely unclear. NO is enzymatically produced by three isoforms of nitric oxide synthase (NOS) enzymes. NOS knockout mice are useful tools to investigate NO function in the lung. Each single NOS knockout mouse does not show obvious lung alveolar phenotype, likely due to compensatory mechanisms. While mice lacking all three NOS isoforms display impaired lung alveolarization, implicating NO plays a pivotal role in lung alveolarization. Argininosuccinate lyase (ASL) is the only mammalian enzyme capable …
Inclisiran: Where Are We On Safety, Efficacy, And Clinical Effectiveness Of Sirna Therapies For Prevention?, Christie M Ballantyne, Abdul Mannan Khan Minhas, Carl E Orringer
Inclisiran: Where Are We On Safety, Efficacy, And Clinical Effectiveness Of Sirna Therapies For Prevention?, Christie M Ballantyne, Abdul Mannan Khan Minhas, Carl E Orringer
Faculty, Staff and Students Publications
No abstract provided.
Mapping The Unseen: Harnessing Indigenous Knowledge Through Participatory Mapping To Address Displacement And Housing Challenges In Post Invasion Iraq, Sana Murrani
School of Art, Design and Architecture
Post-invasion Iraq has been grappling with high rates of internal displacement and severe housing shortages for the past 20years, largely fuelled by violence, genocide and political instability. The intricacy of these interrelated challenges necessitates contextually informed, innovative and participatory approaches to effect change. This paper proposes the use of participatory mapping as a creative tool to tap into the indigenous knowledge and wayfinding skills of Iraqis, fostering a deeper understanding of the lived realities that can contribute to the design of effective policies for managing displacement and housing issues. The rising trend of internal displacement and the subsequent housing shortages, …
Development And Validation Of A Multiplex Real-Time Pcr Assay For Detection And Quantification Of Streptococcus Pneumoniae In Pediatric Respiratory Samples, Molly Butler, Garrett Breazeale, Eric Mwangi, Elaine Dowell, Samuel R Dominguez, Linda Lamberth, Kristina G Hultén, Sarah A Jung
Development And Validation Of A Multiplex Real-Time Pcr Assay For Detection And Quantification Of Streptococcus Pneumoniae In Pediatric Respiratory Samples, Molly Butler, Garrett Breazeale, Eric Mwangi, Elaine Dowell, Samuel R Dominguez, Linda Lamberth, Kristina G Hultén, Sarah A Jung
Faculty, Staff and Students Publications
Streptococcus pneumoniae (Spn) is a bacterial pathogen that causes a range of disease manifestations in children, from acute otitis media to pneumonia, septicemia, and meningitis. Primary Spn laboratory diagnostic identification methods include culture, antigen testing, single-plex real-time PCR, and syndromic PCR panels. However, each method lacks sensitivity, specificity, and/or cost efficiency. We developed and validated a quantitative, multiplex PCR assay using three Spn genomic targets (lytA, piaB, and SP2020) for improved sensitivity and specificity to detect Spn in pleural fluid (PF), bronchoalveolar lavage (BAL), tracheal aspirate (TA), and upper respiratory (UR, research only) samples. Validation testing …
Single-Cell Atlas Of Healthy Human Blood Unveils Age-Related Loss Of Nkg2c+Gzmb−Cd8+ Memory T Cells And Accumulation Of Type 2 Memory T Cells, Marina Terekhova, Amanda Swain, Pavla Bohacova, Ekaterina Aladyeva, Laura Arthur, Anwesha Laha, Denis A Mogilenko, Samantha Burdess, Vladimir Sukhov, Denis Kleverov, Barbora Echalar, Petr Tsurinov, Roman Chernyatchik, Kamila Husarcikova, Maxim N Artyomov
Single-Cell Atlas Of Healthy Human Blood Unveils Age-Related Loss Of Nkg2c+Gzmb−Cd8+ Memory T Cells And Accumulation Of Type 2 Memory T Cells, Marina Terekhova, Amanda Swain, Pavla Bohacova, Ekaterina Aladyeva, Laura Arthur, Anwesha Laha, Denis A Mogilenko, Samantha Burdess, Vladimir Sukhov, Denis Kleverov, Barbora Echalar, Petr Tsurinov, Roman Chernyatchik, Kamila Husarcikova, Maxim N Artyomov
2020-Current year OA Pubs
Extensive, large-scale single-cell profiling of healthy human blood at different ages is one of the critical pending tasks required to establish a framework for the systematic understanding of human aging. Here, using single-cell RNA/T cell receptor (TCR)/BCR-seq with protein feature barcoding, we profiled 317 samples from 166 healthy individuals aged 25-85 years old. From this, we generated a dataset from ∼2 million cells that described 55 subpopulations of blood immune cells. Twelve subpopulations changed with age, including the accumulation of GZMK
Enhancing Learning Experiences In Pre-Clinical Restorative Dentistry: The Impact Of Virtual Reality Haptic Simulators, Alaa Daud, Manal Matoug-Elwerfelli, Hanin Daas, Daniel Zahra, Kamran Ali
Enhancing Learning Experiences In Pre-Clinical Restorative Dentistry: The Impact Of Virtual Reality Haptic Simulators, Alaa Daud, Manal Matoug-Elwerfelli, Hanin Daas, Daniel Zahra, Kamran Ali
Peninsula Dental School
Background: Utilization of Virtual Reality haptic simulation (VRHS) to aid in the training of various pre-clinical skills is of recent interest. The aim of this study was to evaluate the impact of VRHS in restorative dentistry on the learning experiences and perceptions of dental students. Methods: An interventional study design was utilized to recruit third year students. All participants provided informed consents and were randomly divided into two groups. Group 1: Initially performed a Class I cavity preparation with the VRHS, followed by the same exercise using the phantom head/ acrylic typodont teeth in a conventional simulation environment (CSE). Group …
Overall Survival Of Patients With Chl Who Progress After Autologous Stem Cell Transplant: Results In The Novel Agent Era, Sanjal H Desai, Brad Kahl, Raya Saba, Et Al.
Overall Survival Of Patients With Chl Who Progress After Autologous Stem Cell Transplant: Results In The Novel Agent Era, Sanjal H Desai, Brad Kahl, Raya Saba, Et Al.
2020-Current year OA Pubs
In the pre-novel agent era, the median postprogression overall survival (PPS) of patients with classic Hodgkin lymphoma (cHL) who progress after autologous stem cell transplant (ASCT) was 2 to 3 years. Recently, checkpoint inhibitors (CPI) and brentuximab vedotin (BV) have improved the depth and durability of response in this population. Here, we report the estimate of PPS in patients with relapsed cHL after ASCT in the era of CPI and BV. In this multicenter retrospective study of 15 participating institutions, adult patients with relapsed cHL after ASCT were included. Study objective was postprogression overall survival (PPS), defined as the time …
Human-Robot Interactions: Insights From Experimental And Evolutionary Social Sciences, Eric Schniter
Human-Robot Interactions: Insights From Experimental And Evolutionary Social Sciences, Eric Schniter
ESI Working Papers
"Experimental research in the realm of human-robot interactions has focused on the behavioral and psychological influences affecting human interaction and cooperation with robots. A robot is loosely defined as a device designed to perform agentic tasks autonomously or under remote control, often replicating or assisting human actions. Robots can vary widely in form, ranging from simple assembly line machines performing repetitive actions to advanced systems with no moving parts but with artificial intelligence (AI) capable of learning, problem-solving, communicating, and adapting to diverse environments and human interactions. Applications of experimental human-robot interaction research include the design, development, and implementation of …
New Age Insights: Filipino Millennials In Government, Mark Kevin C. Chua, Sherrie Ann C. Labid, Lovely Rose A. Bolante
New Age Insights: Filipino Millennials In Government, Mark Kevin C. Chua, Sherrie Ann C. Labid, Lovely Rose A. Bolante
Makara Human Behavior Studies in Asia
Millennials comprise a significant portion of the demography of the current Philippine workforce. Cognizant of the unique socio-cultural environment that shaped the Generation Y cohort, this descriptive phenomenological qualitative study aimed to explore millennial employees' work expectations and experiences within a government agency in the Philippines. Four themes emerged from the in-depth analysis of the five employees' interview responses: (1) job security and financial stability, (2) socio-emotional support, (3) fulfillment, and (4) professional development opportunities. The qualitative findings of this study emphasize the importance of supporting millennial employees' career growth and fostering a healthy work environment. It indicates that millennial …
A Patterned Human Primitive Heart Organoid Model Generated By Pluripotent Stem Cell Self-Organization, Brett Volmert, Chao Zhou, Et Al.
A Patterned Human Primitive Heart Organoid Model Generated By Pluripotent Stem Cell Self-Organization, Brett Volmert, Chao Zhou, Et Al.
2020-Current year OA Pubs
Pluripotent stem cell-derived organoids can recapitulate significant features of organ development in vitro. We hypothesized that creating human heart organoids by mimicking aspects of in utero gestation (e.g., addition of metabolic and hormonal factors) would lead to higher physiological and anatomical relevance. We find that heart organoids produced using this self-organization-driven developmental induction strategy are remarkably similar transcriptionally and morphologically to age-matched human embryonic hearts. We also show that they recapitulate several aspects of cardiac development, including large atrial and ventricular chambers, proepicardial organ formation, and retinoic acid-mediated anterior-posterior patterning, mimicking the developmental processes found in the post-heart tube stage …
A Multilevel Mhealth Intervention Boosts Adherence To Hydroxyurea In Individuals With Sickle Cell Disease, Jane S Hankins, Allison A King, Ana A Baumann, Lisa M Klesges, Et Al.
A Multilevel Mhealth Intervention Boosts Adherence To Hydroxyurea In Individuals With Sickle Cell Disease, Jane S Hankins, Allison A King, Ana A Baumann, Lisa M Klesges, Et Al.
2020-Current year OA Pubs
Hydroxyurea reduces sickle cell disease (SCD) complications, but medication adherence is low. We tested 2 mobile health (mHealth) interventions targeting determinants of low adherence among patients (InCharge Health) and low prescribing among providers (HU Toolbox) in a multi-center, non-randomized trial of individuals with SCD ages 15-45. We compared the percentage of days covered (PDC), labs, healthcare utilization, and self-reported pain over 24 weeks of intervention and 12 weeks post-study with a 24-week preintervention interval. We enrolled 293 patients (51% male; median age 27.5 years, 86.8% HbSS/HbSβ0-thalassemia). The mean change in PDC among 235 evaluable subjects increased (39.7% to 56.0%; P < 0.001) and sustained (39.7% to 51.4%, P < 0.001). Mean HbF increased (10.95% to 12.78%; P = 0.03). Self-reported pain frequency reduced (3.54 to 3.35 events/year; P = 0.041). InCharge Health was used ≥1 day by 199 of 235 participants (84.7% implementation; median usage: 17% study days; IQR: 4.8-45.8%). For individuals with ≥1 baseline admission for pain, admissions per 24 weeks declined from baseline through 24 weeks (1.97 to 1.48 events/patient, P = 0.0045) and weeks 25-36 (1.25 events/patient, P = 0.0015). PDC increased with app use (P < 0.001), with the greatest effect in those with private insurance (P = 0.0078), older subjects (P = 0.033), and those with lower pain interference (P = 0.0012). Of the 89 providers (49 hematologists, 36 advanced care providers, 4 unreported), only 11.2% used HU Toolbox ≥1/month on average. This use did not affect change in PDC. Tailoring mHealth solutions to address barriers to hydroxyurea adherence can potentially improve adherence and provide clinical benefits. A definitive randomized study is warranted. This trial was registered at www.clinicaltrials.gov as #NCT04080167.
Kids For A Happy Marriage? A Preliminary Study On Marriage Satisfaction And Presence Or Absence Of Children Among Married Individuals In Indonesia, Alftisya Victory Hutabarat, Karel Karsten Himawan
Kids For A Happy Marriage? A Preliminary Study On Marriage Satisfaction And Presence Or Absence Of Children Among Married Individuals In Indonesia, Alftisya Victory Hutabarat, Karel Karsten Himawan
Makara Human Behavior Studies in Asia
Having children after marriage tends to be seen as a normative practice in Indonesia. As a result, individuals who do not have children could be at risk of experiencing a set of social stigmas. The study aims to explore whether having children is associated with one’s marital satisfaction. In particular, the present study aims to explore the differences in marital satisfaction among married individuals who have biological children, who are childfree (voluntarily childless), and who are childless (involuntarily childless). A cross-sectional survey was conducted to 210 married individuals (M age = 34.3; SD = 7.9). The result shows that …
Relationship Between Positive Body Image And Selective Visual Self-Presentation On Social Networking Sites: Moderating Role Of Gender, Asharf Sadat Ahadzadeh, Fon Sim Ong, Saeed Pahlevan Sharif
Relationship Between Positive Body Image And Selective Visual Self-Presentation On Social Networking Sites: Moderating Role Of Gender, Asharf Sadat Ahadzadeh, Fon Sim Ong, Saeed Pahlevan Sharif
Makara Human Behavior Studies in Asia
This study examines the association between positive body image and selective visual self-presentation behaviors on social networking sites, while also considering the moderating influence of gender. We conducted a cross-sectional survey involving 282 undergraduate students in Malaysia (Mage = 20.85, SD = 1.81). The results reveal a negative correlation between positive body image and behaviors such as posing in pictures and editing photos. However, no significant relationship was found between positive body image and photo selection. Gender differences were evident, with females exhibiting higher engagement in posing in pictures, editing, and photo selection compared to males. The findings also …
Index To Volumes 31 And 32, 2003-2004, Bird Observer
Index To Volumes 31 And 32, 2003-2004, Bird Observer
Bird Observer
No abstract provided.
Bird Sightings: July-August, 2004, R. H. Stymeist
At A Glance, Wayne R. Petersen
The Provenance Of Vagrants And Their Evaluation By Rarities Committees, Richard R. Veit
The Provenance Of Vagrants And Their Evaluation By Rarities Committees, Richard R. Veit
Bird Observer
No abstract provided.
Nagog Pond: Inland Gull And Waterfowl Haven, Mike Resch
Nagog Pond: Inland Gull And Waterfowl Haven, Mike Resch
Bird Observer
No abstract provided.
One Birder's Falcon, Matt Pelikan
What's Next After The Red-Footed Falcon? Predictions Of Future Vagrants In Massachusetts, Robert H. Stymeist, Jeremiah R. Trimble
What's Next After The Red-Footed Falcon? Predictions Of Future Vagrants In Massachusetts, Robert H. Stymeist, Jeremiah R. Trimble
Bird Observer
No abstract provided.
Red-Footed Falcon: How Did It Get Here?, Julian Hough
Red-Footed Falcon: How Did It Get Here?, Julian Hough
Bird Observer
No abstract provided.
Massachusetts Miracles: The Gull And The Falcon, Wayne R. Petersen, Paul J. Baicich
Massachusetts Miracles: The Gull And The Falcon, Wayne R. Petersen, Paul J. Baicich
Bird Observer
No abstract provided.
A Tale Of Discovery: The Americas' First Red-Footed Falcon, E. Vernon Laux
A Tale Of Discovery: The Americas' First Red-Footed Falcon, E. Vernon Laux
Bird Observer
No abstract provided.
Identification Of The Martha's Vineyard Red-Footed Falcon, David Allen Sibley
Identification Of The Martha's Vineyard Red-Footed Falcon, David Allen Sibley
Bird Observer
No abstract provided.
Hot Birds, Jeremiah Trimble, Joe Sutherland, Peter Alden, Phil Brown, Glen Tephe, Jonathan Klizas, Eddie Giles
Hot Birds, Jeremiah Trimble, Joe Sutherland, Peter Alden, Phil Brown, Glen Tephe, Jonathan Klizas, Eddie Giles
Bird Observer
No abstract provided.
Letter From The Editor, Carolyn Marsh
At A Glance, Wayne R. Petersen