Digital Commons Network^™

Guidelines For Sustainable Use Of Mobile Instant Messaging Apps In Higher Education: A South African Case Study, Bronwyn C. Swartz, Sweta Patnaik

Higher Learning Research Communications

Objective: The purpose of the study was to propose guidelines to facilitate the sustainable and successful use of mobile instant messaging apps for learning and teaching based on a review of the literature and perceptions of educators. Fraser’s model of redistribution, recognition, and representation served as the theoretical framework. This study provides a mechanism for the development of a socially just and inclusive online classroom environment.

Method: We conducted two focus groups (n = 4 and n = 3) in November 2021 at a university of technology in South Africa to explore the perceptions of educators on using mobile …

Hubungan Tingkat Berat Jenis Urin Dengan Keluhan Kesehatan Akibat Pajanan Panas Pada Pekerja Konstruksi Depo Lrt, Muhammad Syafiq Nafis, Doni Hikmat Hikmat Ramdhan

National Journal of Occupational Health and Safety

Background: Construction workers in Indonesia are among vulnerable workers of the negative impact of heat hazard from the work environment. Past research has found that more than 80% of construction workers experienced dehydration and 100% construction workers have experienced heat-related symptoms/illnesses. Objective: The purpose of this study is to analyze the correlation between dehydration (based on urine specific gravity) and heat-related symptoms/illnesses in depo Light-Rail Transit (LRT) construction workers. Methods: This study used a cross-sectional method from secondary data of work environment heat level measurement, workers’ questionnaire, and workers’ urine specific gravity in depo LRT construction 2021. Results : There …

Analisis Faktor Risiko Gangguan Otot Rangka Akibat Kerja Pada Pekerja Perkantoran Di Instansi X Tahun 2023, Alvina Winners Putri, Indri Hapsari Hapsari Susilowati

National Journal of Occupational Health and Safety

An uncomfortable posture when doing work for a long duration can cause work-related musculoskeletal disorders. The purpose of this study was to determine the risk factors associated with the occurrence of symptoms of work-related musculoskeletal disorders in office workers at Institution X in 2023. This study used a cross-sectional design and the occupational posture assessment Rapid Office Strain Assessment (ROSA) method then to assess complaints of musculoskeletal disorders as a whole subjectively using the NBM (Nordic Body Map). The results showed that the level of risk of complaints of musculoskeletal disorders due to work at the intermediate level requires further …

Analisis Sistem Proteksi Kebakaran Dan Keselamatan Kebakaran Di Stasiun Transit Manggarai Kereta Rel Listrik (Krl) Commuter Line Jabodetabek Tahun 2023, Naila Adinda Achmad, Hendra Hendra

National Journal of Occupational Health and Safety

Stasiun Manggarai is the most active station. In January 2023, Stasiun Manggarai has 150,000 transit users and 14,000 station users per day (Fransisca, 2023). This large number of users can certainly increase the density – and according to research – density can increase the existing potential hazards and risks, including fire hazards. Therefore, this research was conducted to find out the implementation of fire protection and fire safety system at Stasiun Transit Manggarai Kereta Rel Listrik (KRL) Commuter Line Jabodetabek using a descriptive observational method with comparative approach. The author compares the results of implementing fire protection and fire safety …

Analisis Hubungan Stres Kerja Dengan Kecelakaan Kerja Pada Pekerja Konstruksi Proyek Pembangunan Jalan Tol Yogyakarta – Bawen Paket 1 (Seksi 1) Tahun 2023, Shafira Agustina Rachmat, Doni Hikmat Hikmat Ramdhan

National Journal of Occupational Health and Safety

Construction workers are a job with high level of risk. There are many cases of construction workers experiencing stress due to their work, even until accident occurs. Factors that contribute to the occurrence of work stress include physical hazards and psychosocial factors, but it does not rule out the possibility of influence from individual characteristics. This study aims to analyze the correlation between occupational stress and workplace accidents in construction workers at Yogyakarta – Bawen Toll Road Construction Project Package 1 (Section 1) in 2023. This research is a quantitative study with a cross-sectional study design. The factors studied included …

Oncogenic Kras Drives Lipofibrogenesis To Promote Angiogenesis And Colon Cancer Progression, Wen-Hao Hsu, Kyle A Labella, Yiyun Lin, Ping Xu, Rumi Lee, Cheng-En Hsieh, Lei Yang, Ashley Zhou, Jonathan M Blecher, Chang-Jiun Wu, Kangyu Lin, Xiaoying Shang, Shan Jiang, Denise J Spring, Yan Xia, Peiwen Chen, John Paul Shen, Scott Kopetz, Ronald A Depinho

Faculty, Staff and Student Publications

Oncogenic KRAS (KRAS*) contributes to many cancer hallmarks. In colorectal cancer, KRAS* suppresses antitumor immunity to promote tumor invasion and metastasis. Here, we uncovered that KRAS* transforms the phenotype of carcinoma-associated fibroblasts (CAF) into lipid-laden CAFs, promoting angiogenesis and tumor progression. Mechanistically, KRAS* activates the transcription factor CP2 (TFCP2) that upregulates the expression of the proadipogenic factors BMP4 and WNT5B, triggering the transformation of CAFs into lipid-rich CAFs. These lipid-rich CAFs, in turn, produce VEGFA to spur angiogenesis. In KRAS*-driven colorectal cancer mouse models, genetic or pharmacologic neutralization of TFCP2 reduced lipid-rich CAFs, lessened tumor angiogenesis, and improved overall survival. …

Review Of "Is Social Justice Just?", Jonathan Lawler

The Christian Librarian

No abstract provided.

Formate Supplementation Enhances Antitumor Cd8+ T-Cell Fitness And Efficacy Of Pd-1 Blockade, Jared H Rowe, Ilaria Elia, Osmaan Shahid, Emily F Gaudiano, Natalia E Sifnugel, Sheila Johnson, Amy G Reynolds, Megan E Fung, Shakchhi Joshi, Martin W Lafleur, Joon Seok Park, Kristen E Pauken, Joshua D Rabinowitz, Gordon J Freeman, Marcia C Haigis, Arlene H Sharpe

Faculty, Staff and Student Publications

UNLABELLED: The tumor microenvironment (TME) restricts antitumor CD8+ T-cell function and immunotherapy responses. Cancer cells compromise the metabolic fitness of CD8+ T cells within the TME, but the mechanisms are largely unknown. Here we demonstrate that one-carbon (1C) metabolism is enhanced in T cells in an antigen-specific manner. Therapeutic supplementation of 1C metabolism using formate enhances CD8+ T-cell fitness and antitumor efficacy of PD-1 blockade in B16-OVA tumors. Formate supplementation drives transcriptional alterations in CD8+ T-cell metabolism and increases gene signatures for cellular proliferation and activation. Combined formate and anti-PD-1 therapy increases tumor-infiltrating CD8+ T cells, which are essential for …

Musculoskeletal Ultrasonography In Rheumatic Diseases, Erhan Çapkin

Turkish Journal of Medical Sciences

Ultrasonography is an imaging technique based on sound waves used for the evaluation of soft tissues. Sound waves have been used for a long time in nonmedical fields, including military defense systems, radar systems, and detection of icebergs. Technological advances resulted in new techniques becoming available for medical imaging, including ultrasonography, magnetic resonance imaging, and computed tomography. Nowadays, the use of imaging has become a gold standard protocol in the diagnosis of many diseases, and recently developed diagnosis and therapy options provide more efficient treatment of rheumatic diseases. Thus, it has become possible to prevent structural damage and disability in …

Protective Effects Of Swimming Exercises And Metformin On Cardiac And Aortic Damage Caused By A High-Fat Diet In Obese Rats With Type 2 Diabetes, By Regulating The Bcl2/Bax Signaling Pathway, Ebru Özüdoğru, Emrah Atay, Mehtap Savran, Hali̇l Aşci, Özlem Özmen, Şenay Topsakal

Turkish Journal of Medical Sciences

Background/aim: Due to the increasing mortality and morbidity rates in diabetes mellitus (DM), which is one of the biggest health problems of our age, many treatment modalities are still being tried. The positive effects of metformin (MET) and physical exercise (EXE) on the pathophysiology of diabetes are well known. In this study, it was aimed to detail these positive effects of MET and EXE in combination on the basis of inflammation, apoptosis mechanisms, and endogen nesfatin-1 (NES-1) synthesis. Materials and methods: Twenty-seven type 2 DM (DM-2) male Wistar Albino rats were divided into 4 groups, as the high-fat diet (HFD), …

Expression Of Pfkfb Isoenzymes During In Vitro Differentiation Of Mouse Embryonic Stem Cells Into Insulin-Producing Cells, Sai̇me Güzel, Abdullah Yalçin, Yunus Gürpinar, Sabi̇re Güler

Turkish Journal of Medical Sciences

Background/aim: Type 1 diabetes mellitus (T1DM) is caused by the autoimmune-mediated destruction of insulin-producing cells (IPCs) and still has no effective cure. Better understanding of the molecular mechanisms involved in the differentiation of embryonic stem cells (ESCs) into IPCs may help us improve the therapeutic strategies for treating T1DM. 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatases (Pfkfb1-4) are key regulators of glucose metabolism. Although Pfkfb3 has been shown to be required for the growth of early differentiated mouse ESCs (mESCs), more studies are needed to further assess the roles of Pfkfb isoenzymes in embryonic development and differentiation, particularly into specific cell types. In this study, …

Csrp1 Expression Is Associated With A Mesenchymal, Stroma-Rich Tumor Profile And Poor Prognosis In Colon Cancer, Seçi̇l Demi̇rkol Canli

Turkish Journal of Medical Sciences

Background/aim: Cysteine and glycine-rich protein 1 (CSRP1) is involved in the cysteine-rich protein family and is a marker of smooth muscle lineages. In colon cancer, the expression of this gene is associated with poor prognosis. In this study, the aim was to reevaluate its prognostic relationship in independent cohorts and explore potential underlying biological processes that are linked to aggressive behavior in tumors with high CSRP1 expression, such as epithelial-to-mesenchymal transition (EMT), stromal fractions in the tumor microenvironment, and consensus molecular subtypes (CMSs). Materials and methods: RNA sequencing (RNAseq)-, microarray-, and single-cell RNAseq (scRNAseq)-based transcriptomic data were obtained from public …

Relationship Between Surgical Rhinoplasty And Demodex Infestation: A Case-Control Study, Abdullah Demi̇rbaş, Di̇lek Bayramgürler, Emrah Kağan Yaşar, Muhammed Adak, Can İlker Demi̇r

Turkish Journal of Medical Sciences

Background/aim: Human Demodex mites are parasites that live in the pilosebaceous unit and can cause demodicosis. While demodicosis may occur as a primary skin disease, it may also result from immunosuppression and topical or systemic immunosuppressive therapies. Surgical rhinoplasty is one of the most commonly performed cosmetic procedures, and it is the cause of a variety of cutaneous complications, particularly acne, as it affects the skin's adnexal structures. Thus, this study aimed to investigate whether the cutaneous changes in surgical rhinoplasty patients render them vulnerable to Demodex infestation. Materials and methods: Individuals who had undergone rhinoplasty (patients) and age- and …

Ss-D-Glucan Promotes Nf-Κb Activation And Ameliorates High-Let Carbon-Ion Irradiation-Induced Human Umbilical Vein Endothelial Cell Injury, Fang Liu, Yanting Wei, Zhuanzi Wang

Turkish Journal of Medical Sciences

Background/aim: Heavy-ion irradiation seriously perturbs cellular homeostasis and thus damages cells. Vascular endothelial cells (ECs) play an important role in the pathological process of radiation damage. Protecting ECs from heavy-ion radiation is of great significance in the radioprotection of normal tissues. In this study, the radioprotective effect of ß-D-glucan (BG) derived from Saccharomyces cerevisiae on human umbilical vein endothelial cell (EA.hy926) cytotoxicity produced by carbon-ion irradiation was examined and the probable mechanism was established. Materials and methods: EA.hy926 cells were divided into seven groups: a control group; 1, 2, or 4 Gy radiation; and 10 µg/mL BG pretreatment for 24 …

What Is The Impact Of Intraperitoneal Surfactant Administration Against Postoperative Intraabdominal Adhesion Formation? An Experimental Study, Şehmus Pala, Tuncay Kuloğlu, Remzi̇ Atilgan, Zehra Sema Özkan, Serhat Hançer

Turkish Journal of Medical Sciences

Background/Aim: Surfactant is a surface-active substance that, in addition to its detergent effect, also has effects that reduce inflammation and fibrosis. Because of these effects, it was aimed herein to investigate the effect of intraperitoneal surfactant application on preventing postoperative peritoneal adhesion formation in a uterine horn adhesion model. Materials and methods: Twenty-one Wistar albino rats were randomly divided into 3 groups (G1-G3), as follows: G1 (n = 7): control group. The abdomen was opened and then closed; G2 (n = 7): adhesion group. The abdomen was opened. Then, a 2-cm linear incision was made over the right uterine horn, …

Development Of A Gestational Diabetes Risk Assessment Scale: A Validity And Reliability Study, Selma Dağci, Besey Ören

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to develop a gestational diabetes risk assessment scale (GEDRISK). Materials and methods: This methodological study included 652 pregnant women who presented to six public health institutions in İstanbul between September 2021 and February 2022. Content validity was evaluated using the content validity index, while construct validity was assessed through exploratory and confirmatory factor analyses. Item discrimination was examined using Cronbach's alpha coefficients, Spearman-Brown and Guttman coefficients, item-total correlation tests, and 27% lower and upper quartile t tests. Reliability was determined through test-retest analysis methods. Results: The scale-level content validity index demonstrated strong coherence …

Paleoclimate Of The Peruvian Andean Highlands During The Late Holocene, Jarunetr Sae-Lim

Arts & Sciences Graduate Student Theses and Dissertations

The tropical and central Andean highlands (>4,000 m above sea level) supply critical freshwater resources to the Amazon Basin, supporting large communities in mountain regions and lowlands. Due to the scarcity of historical weather data spatially and temporally, it is challenging to quantify hydroclimate and environmental responses to anthropogenic climate change. Paleoclimate reconstruction and modeling can provide critical insights into key hydroclimate processes and how hydroclimate in this region has responded to climate change and variability through time. However, biomarker-based paleoclimate proxy reconstructions are still very rare in this region. This dissertation quantifies local-scale and regional-scale hydroclimate and environmental …

Prevalence Of Missed Opportunities For Immunization And Its Associated Factors Among Children Below Two Years Old Attending Primary Healthcare Centers In Baghdad/Al-Karkh, Baraka Safaa’ Mustafa, Jalil Ibrahim Saleh

Muthanna Medical Journal

Immunization is an effective means for preventing illness and reducing the burden of various infectious diseases. Incomplete or partial immunization poses a serious threat to the health of children in many developing countries, including Iraq. The objectives are to investigate the prevalence of missed opportunities for immunization (MOI) and its associated factors among children aged below two years old attending primary health care centers (PHCCs) in Baghdad/Al-Karkh. A cross-sectional study involving 500 children’s companions attending PHCCs in Baghdad/Al-Karkh from the 1st of September 2022 to the 1st of July 2023. The respondents were enrolled using a systematic random sample technique …

Radicalisation And Extremism On Social Media: What Steps Can Be Taken?, Emeka Williams Etumnu, Oluchi I. Williams-Etumnu

Library Philosophy and Practice (e-journal)

Unarguably, the social media has brought the world together in an online space and as a result of this, extremist groups utilise the social media to radicalise people especially the youths who are vulnerable and fancy their ideology towards their cause. The paper was underpinned on public sphere theory and the desk research method was employed in the course of the study. It was revealed that social media plays a tremendous role towards radicalisation and extremism. The need for digital literacy, where rules can be made to assist individuals of all ages in developing critical thinking skills and building resilience …

Evaluation Of Sestrin 2 And Tribbles Homolog 3 Levels In Obese And Nonobese Women With Polycystic Ovary Syndrome, Ayşegül Çatal, Evri̇m Ebru Kovalak

Turkish Journal of Medical Sciences

Background/aim: This study was designed to evaluate the relationship of two new biomarkers [tribbles homolog 3 (TRB3) and sestrin 2 levels], which were previously associated with obesity, with metabolic parameters in obese and nonobese women with polycystic ovary syndrome (PCOS). Materials and methods: This cross-sectional case control study was conducted between September 2017 and August 2019 in the gynecology department of a tertiary referral hospital. The values of the plasma sestrin 2, TRB3, insulin, fasting plasma glucose, lipid profile, and homeostasis model assessment of insulin resistance (HOMA-IR) were compared in 90 obese women with PCOS (BMI > 30), 90 women with …

Optimizing Sepsis Management Through Enhanced Protocol Compliance In The Emergency Department, Teela Sade Miller-Buford

Master's Projects and Capstones

Abstract

Problem: This quality improvement project aims to enhance early sepsis management and sepsis bundle compliance among Emergency Department nurses to reduce the risk of sepsis-related deaths and hospital length of stays.

Context: A group of students studying to become Clinical Nurse Leaders (CNLs) evaluated Hospital A's Emergency Department (a clinical microsystem) located in the greater Bay Area. This microsystem provides diverse emergency care for patients with various medical conditions and diagnoses. The CNL students concentrated on patients diagnosed with sepsis for their quality improvement project.

Interventions: Although time constraints prevented the implementation of interventions, the CNL students proposed recommendations …

Xtx101, A Tumor-Activated, Fc-Enhanced Anti-Ctla-4 Monoclonal Antibody, Demonstrates Tumor-Growth Inhibition And Tumor-Selective Pharmacodynamics In Mouse Models Of Cancer, Kurt A. Jenkins, Miso Park, Magali Pederzoli-Ribeil, Ugur Eskiocak, Parker Johnson, Wilson Guzman, Megan Mclaughlin, Deborah Moore-Lai, Caitlin O'Toole, Zhen Liu, Benjamin Nicholson, Veronica Flesch, Huawei Qiu, Tim Clackson, Ronan C. O'Hagan, Ulrich Rodeck, Margaret Karow, Jennifer O'Neil, John C. Williams

Department of Dermatology and Cutaneous Biology Faculty Papers

INTRODUCTION: The clinical benefit of the anti-CTLA-4 monoclonal antibody (mAb) ipilimumab has been well established but limited by immune-related adverse events, especially when ipilimumab is used in combination with anti-PD-(L)1 mAb therapy. To overcome these limitations, we have developed XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 mAb.

METHODS: XTX101 consists of an anti-human CTLA-4 mAb covalently linked to masking peptides that block the complementarity-determining regions, thereby minimizing the mAb binding to CTLA-4. The masking peptides are designed to be released by proteases that are typically dysregulated within the tumor microenvironment (TME), resulting in activation of XTX101 intratumorally. Mutations within the Fc region …

The Impact Of High Temperatures On Child Anthropometric Outcomes Worldwide, Natalia A. Cancino Garcia

Master's Theses

High temperatures caused by climate change significantly impact society, including child nutrition. Our research focuses on the impact of high temperatures on the anthropometric outcomes of children aged 1 to 5 in 54 countries worldwide. We analyze the historical climate and anthropometric data to evaluate the effect of high temperature on weight-for-age (WAZ) and weight-for-height (WHZ) in children. Results indicate that high temperatures negatively affect child nutrition, particularly in areas above 20°C, and children in rural areas are more vulnerable. The impact of monthly temperature on child anthropometric outcomes varies across countries, regions, and cultural practices. Economic status alone is …

Hybrid Test-Smell Based Approach For Prediction Of Flaky Tests, Saurabh Bodke

Theses

Regression testing is an essential component in software development, aimed at verifying that recent code changes do not negatively impact existing functionalities. A prevalent challenge in this area is the occurrence of flaky tests, which exhibit inconsistent outcomes—passing or failing without any code alterations. Such tests erode the reliability of automated testing frameworks, leading to increased debugging efforts and diminished confidence in software stability. This research addresses the challenge of flaky tests by exploring machine learning and prediction models, specifically focusing on test smells and four principal root causes of flakiness: Async Wait, Concurrency, Test Order Dependency, and Resource Leak. …

Improving The Test Smell-Based Detection Of Flaky Tests, Shubham Kumar Karum

Theses

Regression testing, a critical process in software development, ensures that the recent code changes have not adversely affected existing functionality. A significant challenge in this domain is the existence of flaky tests—tests that inconsistently pass or fail without any changes to the code. These flaky tests undermine the reliability of automated testing and can lead to increased debugging and decreased confidence in software stability. To tackle the issue of flaky tests, there exists approaches that make use of machine learning and prediction models. However, approaches that rely on analyzing test case vocabulary typically face challenges like higher costs to run …

Enhancing Efficiency And Sustainability: Retrofitting Fluorescent Lights To Leds, Khalifa Alshaiba

Theses

This research work emphasizes the urgent need to implement energy-efficient lighting technologies, particularly the retrofit of fluorescent lights with LED alternatives, in order to reduce energy consumption and greenhouse gas emissions. In addition to that maintaining operational safety and sustainability, improving energy efficiency is essential in Dubai's industries, which are major consumers of electricity and economic drivers. The project's goal is to retrofit energy-efficient LED lighting into a well-known packaging company's current fluorescent lighting systems. In doing so, the project hopes to improve illumination quality and minimize maintenance needs while lowering energy consumption, operating expenses, and environmental impact. The goals …

Myopia Management Algorithm.: Annexe To The Article Titled Update And Guidance On Management Of Myopia. European Society Of Ophthalmology In Cooperation With International Myopia Institute, Beáta Tapasztó, Daniel Ian Flitcroft, Wagih A. Aclimandos, Jost B. Jonas, Jan Tjeerd H.N. De Faber, Zoltán Zsolt Nagy, Philippe G. Kestelyn, Ingrida Januleviciene, Andrzej Grzybowski, Christina Nicolaeva Vidinova, Jeremy A. Guggenheim, Jan Roelof Polling, James S. Wolffsohn, J. Willem L. Tideman, Peter M. Allen, Rigmor C. Baraas, Kathryn J. Saunders, Sara J. Mccullough, Lyle S. Gray, Siegfried Wahl, Irina Yurievna Smirnova, Marino Formenti, Hema Radhakrishnan, Serge Resnikoff, János Németh, Soe Myopia Consensus Group

Research Outputs: 2025-Present

Myopia is becoming increasingly common in young generations all over the world, and it is predicted to become the most common cause of blindness and visual impairment in later life in the near future. Because myopia can cause serious complications and vision loss, it is critical to create and prescribe effective myopia treatment solutions that can help prevent or delay the onset and progression of myopia. The scientific understanding of myopia's causes, genetic background, environmental conditions, and various management techniques, including therapies to prevent or postpone its development and slow its progression, is rapidly expanding. However, some significant information gaps …

Impact Of Methylene Blue On Enhancing The Hydrocarbon Potential Of Early Cambrian Khewra Sandstone Formation From The Potwar Basin, Pakistan, Muhammad Ali, Abdul M. Shar, Nurudeen Yekeen, Hussein Abid, Muhammad S. Kamal, Hussein Hoteit

Research outputs 2022 to 2026

Significant amounts of hydrocarbon resources are left behind after primary and secondary recovery processes, necessitating the application of enhanced oil recovery (EOR) techniques for improving the recovery of trapped oil from subsurface formations. In this respect, the wettability of the rock is crucial in assessing the recovery and sweep efficiency of trapped oil. The subsurface reservoirs are inherently contaminated with organic acids, which renders them hydrophobic. Recent research has revealed the significant impacts of nanofluids, surfactants, and methyl orange on altering the wettability of organic-acid-contaminated subsurface formations into the water-wet state. This suggests that the toxic dye methylene blue (MB), …

Circulating Senescent Myeloid Cells Infiltrate The Brain And Cause Neurodegeneration In Histiocytic Disorders, C Matthias Wilk, Flurin Cathomas, Orsolya Török, Jessica Le Berichel, Matthew D Park, Camille Bigenwald, George R Heaton, Pauline Hamon, Leanna Troncoso, Brooks P Scull, Diana Dangoor, Aymeric Silvin, Ryan Fleischmann, Meriem Belabed, Howard Lin, Elias Merad Taouli, Steffen Boettcher, Long Li, Antonio Aubry, Markus G Manz, Julia K Kofler, Zhenyu Yue, Sergio A Lira, Florent Ginhoux, John F Crary, Kenneth L Mcclain, Jennifer L Picarsic, Scott J Russo, Carl E Allen, Miriam Merad

Faculty, Staff and Students Publications

Neurodegenerative diseases (ND) are characterized by progressive loss of neuronal function. Mechanisms of ND pathogenesis are incompletely understood, hampering the development of effective therapies. Langerhans cell histiocytosis (LCH) is an inflammatory neoplastic disorder caused by hematopoietic progenitors expressing mitogen-activated protein kinase (MAPK)-activating mutations that differentiate into senescent myeloid cells that drive lesion formation. Some individuals with LCH subsequently develop progressive and incurable neurodegeneration (LCH-ND). Here, we showed that LCH-ND was caused by myeloid cells that were clonal with peripheral LCH cells. Circulating BRAFV600E

Apixaban For Prevention Of Thromboembolism In Pediatric Heart Disease, R Mark Payne, Kristin M Burns, Andrew C Glatz, Christoph Male, Andrea Donti, Leonardo R Brandão, Gunter Balling, Christina J Vanderpluym, Frances Bu'lock, Lazaros K Kochilas, Brigitte Stiller, James F Cnota, Otto Rahkonen, Asra Khan, Rachele Adorisio, Serban Stoica, Lindsay May, Jane C Burns, Jose Francisco K Saraiva, Kimberly E Mchugh, John S Kim, Agustin Rubio, Nadia G Chía-Vazquez, Marcie R Meador, Joshua L Dyme, Alison M Reedy, Toni Ajavon-Hartmann, Praneeth Jarugula, Lauren E Carlson-Taneja, Donna Mills, Olivia Wheaton, Paul Monagle

Faculty, Staff and Students Publications

Background: Children with heart disease frequently require anticoagulation for thromboprophylaxis. Current standard of care (SOC), vitamin K antagonists or low-molecular-weight heparin, has significant disadvantages.

Objectives: The authors sought to describe safety, pharmacokinetics (PK), pharmacodynamics, and efficacy of apixaban, an oral, direct factor Xa inhibitor, for prevention of thromboembolism in children with congenital or acquired heart disease.

Methods: Phase 2, open-label trial in children (ages, 28 days to < 18 years) with heart disease requiring thromboprophylaxis. Randomization 2:1 apixaban or SOC for 1 year with intention-to-treat analysis.

Primary endpoint: a composite of adjudicated major or clinically relevant nonmajor bleeding. Secondary endpoints: PK, pharmacodynamics, quality of life, and exploration of efficacy.

Results: From 2017 to 2021, 192 participants were randomized, 129 …