Digital Commons Network^™

On The Benefits Of The Tryptophan Metabolite 3-Hydroxyanthranilic Acid In Caenorhabditis Elegans And Mouse Aging., Hope Dang, Raul Castro-Portuguez, Luis Espejo, Grant Backer, Samuel Freitas, Erica Spence, Jeremy Meyers, Karissa Shuck, Emily A Gardea, Leah M Chang, Jonah Balsa, Niall Thorns, Caroline Corban, Teresa Liu, Shannon Bean, Susan Sheehan, Ron Korstanje, George L Sutphin

Faculty Research 2023

Tryptophan metabolism through the kynurenine pathway influences molecular processes critical to healthy aging including immune signaling, redox homeostasis, and energy production. Aberrant kynurenine metabolism occurs during normal aging and is implicated in many age-associated pathologies including chronic inflammation, atherosclerosis, neurodegeneration, and cancer. We and others previously identified three kynurenine pathway genes-tdo-2, kynu-1, and acsd-1-for which decreasing expression extends lifespan in invertebrates. Here we report that knockdown of haao-1, a fourth gene encoding the enzyme 3-hydroxyanthranilic acid (3HAA) dioxygenase (HAAO), extends lifespan by ~30% and delays age-associated health decline in Caenorhabditis elegans. Lifespan extension is mediated by increased physiological levels of …

Mapping Restricted Introgression Across The Genomes Of Admixed Indigenous African Cattle Breeds., Juliane Friedrich, Richard I Bailey, Andrea Talenti, Umer Chaudhry, Qasim Ali, Emmanuel F Obishakin, Chukwunonso Ezeasor, Jessica Powell, Olivier Hanotte, Abdulfatai Tijjani, Karen Marshall, James Prendergast, Pamela Wiener

Faculty Research 2023

BACKGROUND: The genomes of indigenous African cattle are composed of components with Middle Eastern (taurine) and South Asian (indicine) origins, providing a valuable model to study hybridization and to identify genetic barriers to gene flow. In this study, we analysed indigenous African cattle breeds as models of hybrid zones, considering taurine and indicine samples as ancestors. In a genomic cline analysis of whole-genome sequence data, we considered over 8 million variants from 144 animals, which allows for fine-mapping of potential genomic incompatibilities at high resolution across the genome.

RESULTS: We identified several thousand variants that had significantly steep clines ('SCV') …

Investing In The Future: A Holistic Examination Of Personal And Behavioral Influences On Cryptocurrency Investment, With A Focus On Social Influence And Crypto Expert Guidance, Zainab Safdar, Bushra F. Malik, Huma Ayub, Abida Ellahi

Accounting, Business Analytics, Economics, and Finance Department Faculty Articles

The research aimed to investigate the influence of personal and behavioral factors on cryptocurrency investment, with the introduction of social influence and crypto expert recommendations as moderators to augment the impact of these factors. Utilizing the snowball sampling technique, a survey was conducted with a sample of 349 cryptocurrency investors in Pakistan. The study employed Smart PLS 3.3M3 for moderated mediation analysis of the survey data. Results indicate that personal and behavioral factors significantly and positively impact cryptocurrency investment. Profit expectation serves as a positive mediator in the relationship between personal and behavioral factors and cryptocurrency investment. Additionally, social influence …

Effect Of Selective Memory And Use Of Triangulation To Critique Songwriting, Maxwell A. Ramsey

Recital Papers

The cowriting of three successful popular songs is reconstructed through blind interviews with each of the contributors. In addition to insights into the actual compositional aspects, the interview questions were designed to reveal what role music industry executives may have played in arranging, inspiring, or promoting the songs throughout their journey to find success. The process of triangulation was applied to the interview answers in accordance with previous successful qualitative research methods to uncover the decisions and techniques that proved pivotal in best serving the respective song idea. The ultimate success of the songs is examined through chart and sales …

Insight - Fall 2023, Dugoni School Of Dentistry

Insight

Welcome to the fall 2023 issue of Insight, a newsletter celebrating the accomplishments of our community of scholars. We aim to spotlight insights from people at the Dugoni School working in all areas of scholarship, including clinical or biomedical research, the scholarship of teaching and learning, improvement of the health care system, and professional partnerships that advance the field.

Barriers To Hiring And Retaining Educators In New Hampshire, Melissa N. Fazlic

M.S. in Leadership

The COVID-19 pandemic brought to light the teacher shortage; however, school districts across the country have faced shortages for many years. While the state of New Hampshire is not alone in the shortage of teachers, New Hampshire faces additional barriers when it comes to recruiting and retaining a diverse group of certified educators. This project explores barriers to hiring educators that include: the demand for teachers, the COVID-19 pandemic, teaching reciprocity challenges, budget constraints and low wages, and local competition. The methodology used includes a combination of research using online tools such as Google Scholar, the UNH virtual library, and …

E-Cigarette Use And Respiratory Symptoms In Adults: A Systematic Review And Meta-Analysis, Mohammed M. Alqahtani, Faraj K. Alenezi, Mohammed A. Almeshari, Abdullah M. Alanazi, Ziyad Ben Taleb, Mohammad E Ebrahimi Kalan, Mary P. Martinasek, Rheese J. Mcnab, Rachel Culbreth, Mansour Alotaibi, Hassan Alijohani, Lynda T. Goodfellow, Taha T. Ismaeil, Saleh S. Algarni, Tareq F. Alotaibi, Mobarek K. Alqahtani, Hamoud Al-Ajel, Khalid S. Alwadeai, Nafea S. Almutairi, Eric Ford

APC Fund

Introduction:
Electronic cigarette (e-cigarette) use is gaining popularity among adults. Monitoring e-cigarette-induced respiratory symptoms is crucial for both clinical and regulatory purposes. We systematically reviewed the current literature to understand the prevalence of respiratory symptoms among exclusive e-cigarette users, dual users, and former smokers.

Methods:
Databases searched included PubMed, CINAHL, Cochrane Library, Embase, and Scopus. We included all English-language, empirical quantitative articles that explored the prevalence of e-cigarette-related respiratory symptoms. Random-effects models were utilized in conducting the meta-analyses. The quality of identified studies was evaluated using the NIH Study Quality Assessment Tools. This study is registered with PROSPERO(#CRD42020165973).

Results:
The …

Salamander Modeling: Bridging The Gaps In Environmental Science Accessibility, Grace Leopold

Honors Program Theses and Projects

In the realm of science education, ensuring inclusivity and accessibility for all students, especially those with Individualized Education Programs (IEPs), is an imperative goal. IEPs are customized plans designed to support students with diverse learning needs, which can encompass a broad spectrum of disabilities and learning differences (Shaw, 2021). Providing learners with an IEP is an integral part of Special Education, however, there are a host of overarching challenges faced by students with IEPs in science education, especially in environmental science classes. In this thesis, the development and application of clay salamander models are evaluated for their potential to provide …

Clausewitzian Theory Of War In The Age Of Cognitive Warfare, Amber Brittain-Hale, Amber Brittain-Hale

Education Division Scholarship

We can reconceptualise warfare by contrasting Clausewitz with the modern practice of cognitive warfare, as evidenced by Ukraine’s defence methodologies. The strategic orchestration of ‘infopolitik’ and the sophisticated use of social media can shape narratives and public perception. This article revisits Clausewitz’s tenet of war as a political instrument and juxtaposes it with contemporary conflict’s multidimensional tactics. By scrutinising Ukraine’s digital and psychological warfare tactics, one may question the applicability of Clausewitz’s framework, seeking to understand if these novel dimensions of warfare compel a redefinition or an expansion of his thesis to navigate the complexities of contemporary geopolitical confrontations.

Usa V. Marc Harris

2023 Decisions

USDC for the Eastern District of Pennsylvania

Jesus Munoz-Maceda V. Attorney General United States Of America

2023 Decisions

Agency

Usa V. Akeem Gumbs

2023 Decisions

USDC for the District Court of the Virgin Islands

Usa V. Edwin Torres

2023 Decisions

USDC for the District of New Jersey

Shelly Gross V. Peter Cairo

2023 Decisions

USDC for the Middle District of Pennsylvania

Usa V. Hakim Handy

2023 Decisions

USDC for the Middle District of Pennsylvania

George Willis Bailey Papers, 1937-2005, George Bailey

Center for Restoration Studies Archives, Manuscripts and Personal Papers Finding Aids

Finding aid for the George Willis Bailey Papers.

Minutes, Crummer Graduate School Faculty Meeting, Thursday, December 14, 2023, Crummer Graduate School Of Business Faculty

Crummer Graduate School of Business Minutes and Reports

No abstract provided.

Usa V. Marc Harris

2023 Decisions

USDC for the Eastern District of Pennsylvania

Finding Aid For George Willis Bailey Papers, 1937-2005, George Bailey

George Willis Bailey Papers

The finding aid for the George Willis Bailey Papers is attached to this record as a PDF file.

The Un-Final, Stefanie Kistler

Digital Edition

An independent student produced newspaper from the University of New Hampshire.

Mackie, Martin, And Inus In The Morning: Explaining Mackie’S Inus Conditions Through The Humor Of Demetri Martin, Steven Gimbel

Philosophy Faculty Publications

Distinguishing necessary and sufficient conditions can be challenging to undergraduate logic and critical thinking students. Explaining J. L. Mackie’s notion of INUS conditions—insufficient but necessary parts of unnecessary but sufficient conditions—is an even more difficult concept to understand. It is helpful to have memorable examples that not only clarify the concept, but make it easy to remember. Law student turned stand-up comedian Demetri Martin uses necessary, sufficient, and INUS conditions to construct absurdist jokes. These jokes provide effective tools for making Mackie’s notion understandable and memorable.

A Year Of Wins For Farmed Animals, Lewis Bollard

General – Farm Animal Issues

Although the European Union shelved its ambitious farmed animal welfare reforms, there were other “wins” for farmed animals in 2023. There were 130 new corporate pledges to eliminate cages for laying hens and the worst abuses of broiler chickens. So far, over 1,000 corporate pledges have been fully implemented, and 39% of American hens, 60% of European hens, and 80% of British hens are cage-free, up from 6%, 41%, and 48%, respectively, a decade ago. The US Supreme Court upheld California’s Proposition 12, which bans the sale of eggs, pork, and veal from caged animals and their offspring in California. …

The Minutes Of The Marshall University Staff Council Meeting, December 2023, Marshall University Staff Council

Staff Council Minutes

No abstract provided.

Grit And Heart, Eric F. Spina

President's Blog: From the Heart

“We had a motto of getting 1% better each day and playing with heart for each other,” reflected middle blocker Alayna (Laney) Yates after the Flyer volleyball team’s historic 32-3 season. “We were all in.”

This Business Professor Gave His Students An Object Lesson In Trusting Ai Over Human Judgment, Matt Windsor

Browse All News

No abstract provided.

Love It Or Hate It, Generative Ai Is Not Going Away, Matt Windsor

Browse All News

No abstract provided.

4 Chosen As Uab Vips For Fourth-Quarter 2023, Staff

Browse All News

No abstract provided.

Graduate School And Global Affairs: Newly Formed Unit Is Powered By Strategic Thinking And Bold Vision, Reporter Staff

Browse All News

No abstract provided.

2023 December 14 - Academic Council Agenda And Minutes, Academic Council, East Tennessee State University

Academic Council Agenda and Minutes

No abstract provided.

Gardner-Webb University Welcomes New Head Football Coach Cris Reisert, Office Of University Communications

Gardner-Webb NewsCenter Archive

Gardner-Webb University welcomed new Head Football Coach Cris Reisert on Thursday, Dec. 14. Students, student-athletes, faculty and sta! were joined by alumni, the community and media for the event held in the GW Football Center at Spangler Stadium.