Digital Commons Network^™

Acidosis-Mediated Increase In Ifn-Γ-Induced Pd-L1 Expression On Cancer Cells As An Immune Escape Mechanism In Solid Tumors, Philipp Knopf, Dimitri Stowbur, Sabrina H L Hoffmann, Natalie Hermann, Andreas Maurer, Valentina Bucher, Marilena Poxleitner, Bredi Tako, Dominik Sonanini, Balaji Krishnamachary, Sanhita Sinharay, Birgit Fehrenbacher, Irene Gonzalez-Menendez, Felix Reckmann, David Bomze, Lukas Flatz, Daniela Kramer, Martin Schaller, Stephan Forchhammer, Zaver M Bhujwalla, Leticia Quintanilla-Martinez, Klaus Schulze-Osthoff, Mark D Pagel, Marieke F Fransen, Martin Röcken, André F Martins, Bernd J Pichler, Kamran Ghoreschi, Manfred Kneilling

Faculty, Staff and Student Publications

Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) of solid tumors. In the TME, programmed death-ligand 1 (PD-L1) expression on cancer cells is mainly regulated by Interferon-gamma (IFN-γ), which induces T cell exhaustion and enables tumor immune evasion. In this study, we demonstrate that acidosis, a common characteristic of solid tumors, significantly increases IFN-γ-induced PD-L1 expression on aggressive cancer cells, thus promoting immune escape. Using preclinical models, we found that acidosis enhances the genomic expression and phosphorylation of signal transducer and activator of transcription …

From House Party To World Dominance: Celebrating 50 Years Of Hip Hop: A Bibliography, Cassandra Chaney

Journal of Hip Hop Studies

In 2023, the culture celebrated the 50th birthday of Hip Hop. While there is an ongoing argument of when Hip Hop started, Hip Hop culture marked Clive “DJ Kool Herc” Campbell’s legendary 1973 party at 1520 Sedgwick Avenue in the Bronx, NY as the day to commemorate its humble beginnings. This work provides a bibliographical list of published articles, interviews, book reviews, forthcoming books, and live performances from various artists that made a major impact on Hip Hop. In particular, the bibliography highlights the mark that Hip Hop has made on fashion, the economy, language, and the unique contributions that …

Foreword, Courtney Terry

Journal of Hip Hop Studies

Foreword for volume 10 issue 1.

Beyond Whiteness: Revisiting Jews In Ethnic America, Jonathan Karp

The Jewish Role in American Life: An Annual Review

The concept of ethnicity, once in vogue, has largely gone out of fashion among twenty-first-century social scientists, now replaced by models of assimilation defined in terms of the construction of whiteness and white supremacy. Beyond Whiteness: Revisiting Jews in Ethnic America explores the benefits of reconfiguring the ethnic concept as a tool to analyze the experiences of twentieth-century American Jews—not only in relation to other “white” groups of European descent, but also African Americans and Asian Americans, among others. The essays presented here, ranging from comparative studies of Jews and Asians as “model minorities” to the examination of postethnic “Jews …

Jews And Urban Life, Leonard J. Greenspoon

Studies in Jewish Civilization

Jews and Urban Life recognizes that throughout their long history, Jews have often inhabited cities. The reality of this urban experience ranged from ghetto restrictions to robust participation in a range of civic and social activities. Essays in this collection present relevant examples from within the Jewish community itself, moving historically from the biblical period to the modern-day State of Israel. Taking a comparative approach while recognizing the particulars of individual instances, authors examine these phenomena from a wide variety of approaches, genres, and media. Interdisciplinary and accessibly written, the articles display a multitude of instances throughout history showing the …

Limiting Privilege: Upward Mobility Within Higher Education In Socialist Poland, Agata Zysiak

Central European Studies

State socialism tried to industrialize, urbanize, encourage the more frequent washing of hands, urge people to leave the church, emancipate women, and electrify cities—all within a single lifetime. Central to these initiatives was extending educational opportunities to the working class and creating a vision of an egalitarian socialist university that offered advancement for all. Limiting Privilege: Upward Mobility Within Higher Education in Socialist Poland traces the possibilities and limits of this goal by looking at a model socialist university established in 1945 in the working-class city of Łódź, Poland. Initially a flagship project of socialist modernization, the university tried to …

Women, Nationalism, And Social Networks In The Habsburg Monarchy, 1848–1918, Marta Verginella

Central European Studies

Women, Nationalism, and Social Networks in the Habsburg Monarchy, 1848–1918 focuses on the lives of women in Southeastern Europe during the nineteenth and twentieth centuries, exploring the intersection of gender and nationalism. By looking at a wide range of sources and employing rich historiography, this collection investigates the currents of women’s emancipatory efforts in a climate of conflicting assumptions relating to nationhood and nationalization. This book sheds light on a time when both women and nations were working to assert themselves, and how women promoted the national cause in an attempt to assume stronger roles in the public sphere. The …

Hinchas De Nueva York: Identidad Latina En El Negocio De La Mls, Francisco Uranga

Capstones

En América Latina, la política atraviesa el fútbol desde que la pelota rueda. Fue un ámbito de oposición y lucha en la última dictadura argentina, también durante las protestas de Chile en 2019 y de Perú en 2020. Son sólo ejemplos de una larga tradición. La MLS es una liga joven, con poca tradición, pero ya mostró que puede ser un territorio en disputa. Apetecible para la extrema derecha, aunque con poca recepción. Abierta a las ideas progresistas y antirracistas. Caldo de nuevas identidades latinas, porque empuja hacia la unidad de naciones divididas y a compartir culturas. Y porque la …

The Matriarchs Of Ecuavoley Femenino, Mariana Martinez

Capstones

At Cancha Chavelita (Chavelita Court) in the Bronx, New York, generations of Ecuadorean women have come together to play ecuavoley, a male-dominated sport from Ecuador. Ironically, the court however happens to also be one of the few run by a woman, Chavelita herself. As the women embrace the sport, they’ve become more than just teammates on the court. The capstone project also documents the history of ecuavoley femenino (female ecuavoley) in Ecuador with an in-depth podcast featuring Mercedes (Meche) Mena, a professional ecuavoley player. A third component of the project also explores the rise of ecuavoley femenino on the internet …

Road To Recovery For Craniotomy Patients, Louisa Ustrzynski

Doctor of Nursing Practice Projects

Complications from craniotomy surgery can range from 8-33%, leading to prolonged hospital stays, increased costs, increased risks for complications, and decreased satisfaction. An extensive literature was conducted highlighting Enhanced Recovery After Surgery (ERAS) protocol enhances patient outcomes by emphasizing education, early mobilization, pain management, and proper medication use before surgery. This quality improvement project focused on implementing preoperative and postoperative education in a tertiary hospital outpatient setting targeting adults undergoing craniotomy surgery. The process was implemented by a preoperative checklist and education materials to aid in educating patients on ERAS protocol to decrease the length of stay and increase patient …

Development And Initial Validation Of The Pain Progress Measure, Adnan N. Balisi

Philippine Journal of Physical Therapy

Introduction: Current numerical rating scales for pain mostly measure symptom intensity. There is a need to develop outcome measures reflecting the multifaceted nature of pain. The purpose of this study is to describe the development and validation of the Pain Progress Measure (PPM), which is an outcome measure intended to capture the holistic nature of pain.

Methods: The author developed 15 pain assessment items related to the biopsychosocial theory of pain. For content validity, 14 expert panelists were purposely selected to assess items as either essential, or useful but not essential, and not essential. The number of essential items …

A Retrospective Survey Of Joint Mobilization Utilization During Clinical Internship Of Silliman University Physical Therapy Alumni, Lily Ann Bautista, Regina Bautista, Andrei Altavas, Leanna Bautista

Philippine Journal of Physical Therapy

Introduction: Physical therapy interns of Silliman University reported limited exposure to the application of joint mobilization techniques during their clinical internship training program. The study aimed to determine whether joint mobilization is utilized in physical therapy internships, including the barriers and challenges affecting its use. The study described (1) the interns' self-reported knowledge and awareness of the benefits, principles, type, and indications of joint mobilization, (2) the use of joint mobilization with regards to practice settings and locations, (3) the interns' self-assessment of competency to perform joint mobilization techniques after graduation, and (4) the barriers to increased utilization during clinical …

Spoiling The Party? Heidegger’S Lectures On Trakl At Spa Bühlerhöhe, Tobias Keiling, Ian Alexander Moore

Philosophy Faculty Works

No abstract provided.

An Empirical Study Of Machine Learning Techniques For Accurate Stock Price Forecasting, Daniel Paliulis, Hari Patchigolla

Honors Scholar Theses

This paper presents a comprehensive approach to predicting future stock prices of companies using machine learning and time series analysis. The research problem is centered around addressing the complexity and emotion-driven nature of stock investment decisions. To create an objective determinant in stock decisions, we propose a machine learning model utilizing time series data from major companies, including Amazon, Apple, Google, Nvidia, Meta, Tesla, Salesforce, Intel, and Microsoft. We explore the use of Long Short-Term Memory (LSTM) neural networks, to capture the temporal dynamics of stock prices. These models are designed to process sequential data, maintaining short term and long …

Assessing Leadership In Business: A Critical Investigation Of Mary Barra, Krisha Patel

Honors Scholar Theses

Understanding what makes a good leader is a topic of ongoing interest in the practice of business. Research to-date has distinguished between being a manager and being a leader and also has established a set of principles to consider in assessing leadership. In this thesis, I draw upon principles of leadership, including emotional intelligence; vision creation; inspiring others; leading in good and difficult times; fostering, developing, and recognizing others; and creating a winning culture to offer a critical assessment of Mary Barra as a leader within the business arena.

Investigating The Curricular Practices Of Social Innovation Master’S Programs In The United States, Ty M. Krueger

Masters Projects

The study of social innovation in higher education has increased as more schools add undergraduate and graduate programs on the broad topic. Discussion on what should be included as part of social innovation education has been occurring for decades, but there is little determination as to what could be considered as standards or even a baseline for curricular practices. This research aims to look at how current graduate programs for social innovation are defining the topic, what courses they include in their curriculum, what teaching methods are used in the delivery of these topics, and how the topics and teaching …

Spatial Subsetting Enables Integrative Modeling Of Oral Squamous Cell Carcinoma Multiplex Imaging Data, Jakob Einhaus, Dyani K. Gaudilliere, Julien Hedou, Dorien Feyaerts, Michael G. Ozawa, Masaki Sato, Edward A. Ganio, Amy S. Tsai, Ina A. Stelzer, Karl C. Bruckman, Jonas N. Amar, Maximilian Sabayev, Thomas A. Bonham, Joshua Gillard, Maïgane Diop, Amelie Cambriel, Zala N. Mihalic, Tulio Valdez, Stanley Y. Liu, Leticia Feirrera, David K. Lam, John B. Sunwoo

Pacific Faculty Work

Oral squamous cell carcinoma (OSCC), a prevalent and aggressive neoplasm, poses a significant challenge due to poor prognosis and limited prognostic biomarkers. Leveraging highly multiplexed imaging mass cytometry, we investigated the tumor immune microenvironment (TIME) in OSCC biopsies, characterizing immune cell distribution and signaling activity at the tumor-invasive front. Our spatial subsetting approach standardized cellular populations by tissue zone, improving feature reproducibility and revealing TIME patterns accompanying loss-of-differentiation. Employing a machine-learning pipeline combining reliable feature selection with multivariable modeling, we achieved accurate histological grade classification (AUC = 0.88). Three model features correlated with clinical outcomes in an independent cohort: granulocyte …

Engaging Older Immigrants To Learn English: Advocating For Late-In-Life Learning For Everyone, Susan Marie Filous

Master's Projects and Capstones

In the United States, late-in-life and aging-in-place immigrants require basic English language skills to support their ability to independently access economic, medical, housing, legal, and social services. Older immigrants typically rely on family members, potentiating the risks of neglect and dependency. There is an opportunity to expand their agency in society by increasing their English proficiency.

Foreign language geragogy supports differentiated educational strategies for older learners. There is no upper age limit on the ability to learn a new language, and there are new methods and practices to teach foreign languages to older students. It is insufficient to mainstream older …

Living Among Wildlife: Elevating Human-Wildlife Interactions And Coexistence, Bridget Rebecca Murphy

Graduate Student Portfolios, Professional Papers, and Capstone Projects

After a semester of learning, both in class and in nature, my writing honed in further on this human-nature divide. To me, I see humans as part of nature – as we are mammals, animals, part of the food chain, biological beings no higher than others on our planet. We have simply constructed this false narrative around us within our societies, minds and media that embeds this division between us and nature, between us and wildlife. Humans have been managing, stewarding, living off and within landscapes for thousands of years. As time and technology evolved, a lot of people began …

Monitoring Time Domain Characteristics Of Parkinson's Disease Using 3d Memristive Neuromorphic System, Md Abu Bakr Siddique, Yan Zhang, Hongyu An

Michigan Tech Publications

INTRODUCTION: Parkinson's disease (PD) is a neurodegenerative disorder affecting millions of patients. Closed-Loop Deep Brain Stimulation (CL-DBS) is a therapy that can alleviate the symptoms of PD. The CL-DBS system consists of an electrode sending electrical stimulation signals to a specific region of the brain and a battery-powered stimulator implanted in the chest. The electrical stimuli in CL-DBS systems need to be adjusted in real-time in accordance with the state of PD symptoms. Therefore, fast and precise monitoring of PD symptoms is a critical function for CL-DBS systems. However, the current CL-DBS techniques suffer from high computational demands for real-time …

Terahertz Permittivity Parameters Of Monoclinic Single Crystal Lutetium Oxyorthosilicate, Sean Knight, Steffen Richter, Alexis Papamichail, Megan Stokey, Rafał Korlacki, Vallery Stanishev, Philipp Kühne, Mathias Schubert, Vanya Darakchieva

Department of Electrical and Computer Engineering: Faculty Publications

The anisotropic permittivity parameters of monoclinic single crystal lutetium oxyorthosilicate, Lu₂SiO₅ (LSO), have been determined in the terahertz spectral range. Using terahertz generalized spectroscopic ellipsometry (THz-GSE), we obtained the THz permittivities along the a, b, and c^⋆ crystal directions, which correspond to the ε_a; ε_b, and ε_c? on-diagonal tensor elements. The associated off diagonal tensor element ε_ac? was also determined experimentally, which is required to describe LSO’s optical response in the monoclinic a–c crystallographic plane. From the four tensor elements obtained in the model fit, we calculate the …

Creativity Of Librarians As Determinant Of Job Performance In Some Selected Polytechnic Libraries In Delta State, Nigeria, Patrick Chukwuma Iheme Mr, Chika Chinonso Ejiakor Mrs, Peter O. Moneke, Oluchi Juliet Nwagu, Ufuoma Eruvwe Dr

Library Philosophy and Practice (e-journal)

The study investigated the creativity of librarians as determinant of job performance in some selected polytechnic libraries in Delta State. The study adopted a descriptive survey using questionnaire to collect data. The population of the study consists of 45 librarians. A total of 45 questionnaires were distributed only 33 were retrieved using descriptive statistics, the mean and percentage of the data were calculated. A mean score of 2.5 or above and a percentage score of 50% were taken into consideration. The study revealed five (5) creativity factors possess by librarians in some selected polytechnic libraries in Delta state as experience, …

The Effect Of Visual Arts On At-Risk Students, Nicole E. Seidler

Dissertations, Theses, and Projects

Creation through visual art is demonstrated by a variety of all ages. Visual art-based learning is known to build focus, reduce stress, provide a sense of accomplishment, and spark an increase in well-being. Many people have been known to benefit from the creation of art. With the COVID-19 pandemic back in 2020, educators across the country have noticed an increase of students who are considered at-risk. Many school districts have made it a priority to look at ways of improving these students’ behavior, participation, view on school, or overall well-being. This research study takes place at a rural Wisconsin high …

Introduction To Lgbtq+ Studies, Allison P. Brown, Deborah P. Amory

Milne Library

Introduction to LGBTQ+ Studies was a collaborative, multi-year open textbook project that engaged faculty authors, librarians, a university press, and OER professionals. The resulting textbook takes a cross-disciplinary approach to the study of LGBTQ+ issues that helps students grasp core concepts through a variety of different perspectives. The text offers accessible, academically sound information on a wide range of topics, including history, culture, and Queer Theory; an exploration of LGBTQ+ relationships, families, parenting, health, and education; and how to conduct research on LGBTQ+ topics. This case study will cover the project’s transformation through years of development, including engaging a large …

Enrichment-Planting With Pines Alters Fuel Amount And Structure In Endangered Araucaria Araucana Forests In Northwestern Patagonia, Argentina, Sofia Cingolani, Ignacio A. Mundo, Ivan Barbera, Andrés Holz, Thomas T. Veblen, Juan Paritsis

Geography Faculty Publications and Presentations

The introduction of non-native tree species for large-scale afforestation may alter the fire regime of native ecosystems by modifying fuel proprieties. We quantified changes in fuel abundance and structure resulting from the establishment of commercial Pinus spp. plantations in Araucaria araucana ecosystems in northwestern Patagonia, Argentina. Specifically, we assessed the amount, distribution, and condition (live/dead) of surface and standing fine fuel in A. araucana stands with mature pine plantations (i.e. > 20 cm dbh) and in stands dominated only by A. araucana (control). Our study shows that both types of stands are prone to wildfires, but pine plantations have fuel characteristics …

Enhancing Wettability Prediction In The Presence Of Organics For Hydrogen Geo-Storage Through Data-Driven Machine Learning Modeling Of Rock/H2/Brine Systems, Zeeshan Tariq, Muhammad Ali, Nurudeen Yekeen, Auby Baban, Bicheng Yan, Shuyu Sun, Hussein Hoteit

Research outputs 2022 to 2026

The success of geological H2 storage relies significantly on rock–H2–brine interactions and wettability. Experimentally assessing the H2 wettability of storage/caprocks as a function of thermos-physical conditions is arduous because of high H2 reactivity and embrittlement damages. Data-driven machine learning (ML) modeling predictions of rock–H2–brine wettability are less strenuous and more precise. They can be conducted at geo-storage conditions that are impossible or hazardous to attain in the laboratory. Thus, ML models were utilized in this research to accurately model the wettability behavior of a ternary system consisting of H2, rock minerals (quartz and mica), and brine at different operating geological …

Crank Shaft Road Electromagnetic Road Energy Harvester For Smart City Applications, Niloufar Zabihi, Zewen Gu, Mohamed Saafi

School of Engineering, Computing and Mathematics

This paper addresses the issue of providing cheap and on-demand electricity to low-power devices and sensors of smart cities and infrastructures. A new design for an electromagnetic road energy harvester is proposed, and its performance is evaluated through numerical simulations and experiments. The new method can generate sufficient electricity to run the low-power facilities of the smart cities in real-time and provide enough power for further applications using energy storage devices. Unlike the current road energy harvesters, the new harvester has a compact design, negligible mismatch risk between the components, and is more compatible with high-speed roadways. It can be …

Gender Representation In Indian Television Advertisements From 2011 To 2020, Himika Akram

Electronic Theses & Dissertations

This thesis delves into the ways in which gender is portrayed in Indian television advertisements, with a focus on key areas such as male and female ratio as primary characters, in voiceovers, at home, outdoor, and workplace settings, and finally, in product categories. The thesis draws on a content analysis of 120 strategically selected Indian television advertisements from 120 brands from 2011 to 2020. Findings reveal that men were portrayed as the primary characters in 54.6% of these advertisements, and females were portrayed as the primary characters in 45.4% of advertisements. For voiceovers, the male ratio was 70.1%, and the …

Optimization Of Transition-Metal Inclusive Carbon Aerogels For Electrochemical Energy Applications, Allen Dalton Davis

Electronic Theses & Dissertations

The ever-growing need for energy alongside rising concerns for climate change demands the development of renewable energy technologies. Hydrogen fuel cells are a promising technology that can serve to either supplement energy generation or act as a lone power source. Yet for these devices to be truly green, the hydrogen that serves as fuel must be procured from a renewable resource. Electrolytic water splitting is a process that allows for the dissociation of water into H₂ and O₂. For this process to be practical, the electrolyzer needs to demonstrate high efficiency and stability, as well as a …

Habitat And Demography Of The Ozark Chinquapin (Castanea Ozarkensis) At Roaring River State Park In Barry County, Missouri, Danielle Evilsizor

Electronic Theses & Dissertations

The Ozark chinquapin, Castanea ozarkensis Ashe, is a chestnut tree with a range concentrated in the Interior Highlands of North America. Like other North American members of Castanea, it was reduced from an overstory tree to an understory shrub by the invasive chestnut blight fungus (Cryphonectria parasitica [Murrill] M.E. Barr) during the early 20^th century. However, relatively little is known about the habitat of this species or its health and reproductive capability post chestnut blight. Chapter one of this study analyzed the habitat of this species through a random forest species distribution model (SDM) to predict where …