Digital Commons Network^™

December 15, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

[Excerpt From] Critical Conversations In Healthcare: Scripts & Techniques For Effective Interprofessional & Patient Communication (3rd Ed.), Cheri Clancy

Sigma Publications: Book Excerpts

This item record pertains to an excerpt from Critical Conversations in Healthcare, 3rd Edition, which is provided free of charge by the publisher.

About this book: Critical Conversations in Healthcare, Third Edition, provides scripts and scenarios to facilitate better, more effective communication in healthcare settings.

Protocol To Build A Drug-Testing Pipeline Using Large Populations Of Drosophila Melanogaster, Jay Deloriea, Cassandra Millet-Boureima, Chiara Gamberi

Biology

As a small animal that recapitulates many fundamental aspects of human disease, Drosophila lends itself to probing the biological activity of molecules and drug candidates. Here, we present a protocol to build a drug-testing pipeline in Drosophila. We describe steps for generating synchronous populations of Bicaudal C mutants by genetic crossing and wild-type fly culturing for controlled compound administration and exemplary phenotypic assays. For complete details on the use and execution of this protocol, please refer to Millet-Boureima et al.,¹ Millet-Boureima et al.,² and Gamberi et al.³

Optimal Control Of Ion Exchange Process For Chromate Removal And Protein A Chromatography For Antibody Extraction, Fadi Ghanem

Theses and Dissertations

Ion exchange resins are widely used in the extraction of hazardous chemicals as well as the recovery of precious molecules. Therefore, an early breakthrough from the resin system can lead to toxic compounds affecting the drinking water quality or inefficient use of costly resins. Hence, accurate modeling of the ion exchange process and control strategy can enable decisions that assist in avoiding leakage when facing fluctuations in the inlet contaminant concentrations. In this work, the ion exchange process is modeled via the method of moments where the system uncertainties are captured via stochastic modeling using Ito processes. The flow rate …

Diversity And Dissemination Of Viruses In Pathogenic Protozoa, Senne Heeren, Ilse Maes, Mandy Sanders, Lon-Fye Lye, Vanessa Adaui, Jorge Arevalo, Alejandro Llanos-Cuentas, Lineth Garcia, Philippe Lemey, Stephen M Beverley, James A Cotton, Jean-Claude Dujardin, Frederik Van Den Broeck

2020-Current year OA Pubs

Viruses are the most abundant biological entities on Earth and play a significant role in the evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of viruses has been linked to an increased risk of treatment failure and severe clinical outcome. Here, we studied the molecular epidemiology of the zoonotic disease cutaneous leishmaniasis in Peru and Bolivia through a joint evolutionary analysis of Leishmania braziliensis and their dsRNA Leishmania virus 1. We show that parasite populations circulate in tropical rainforests and are associated with single viral lineages that appear in low prevalence. In contrast, groups of hybrid parasites …

A Single C-Terminal Residue Controls Sars-Cov-2 Spike Trafficking And Incorporation Into Vlps, Debajit Dey, Enya Qing, Yanan He, Yihong Chen, Benjamin Jennings, Whitaker Cohn, Suruchi Singh, Lokesh Gakhar, Nicholas J Schnicker, Brian G Pierce, Julian P Whitelegge, Balraj Doray, John Orban, Tom Gallagher, S Saif Hasan

2020-Current year OA Pubs

The spike (S) protein of SARS-CoV-2 is delivered to the virion assembly site in the ER-Golgi Intermediate Compartment (ERGIC) from both the ER and cis-Golgi in infected cells. However, the relevance and modulatory mechanism of this bidirectional trafficking are unclear. Here, using structure-function analyses, we show that S incorporation into virus-like particles (VLP) and VLP fusogenicity are determined by coatomer-dependent S delivery from the cis-Golgi and restricted by S-coatomer dissociation. Although S mimicry of the host coatomer-binding dibasic motif ensures retrograde trafficking to the ERGIC, avoidance of the host-like C-terminal acidic residue is critical for S-coatomer dissociation and therefore incorporation …

Regular Ideals, Ideal Intersections, And Quotients, Jonathan H. Brown, Adam H. Fuller, David R. Pitts, Sarah A. Reznikoff

Department of Mathematics: Faculty Publications

Let B ⊆ A be an inclusion of C^∗ -algebras. We study the relationship between the regular ideals of B and regular ideals of A.We show that if B ⊆ A is a regular C^∗ -inclusion and there is a faithful invariant conditional expectation from A onto B, then there is an isomorphism between the lattice of regular ideals of A and invariant regular ideals of B. We study properties of inclusions preserved under quotients by regular ideals. This includes showing that if D ⊆ A is a Cartan inclusion and J is a regular ideal in A, …

Synthetic Produced Water Treatment By Directional Solvent Extraction In A Semi-Continuous System, Pablo Vicaria

Masters Theses (Archived)

Directional Solvent Extraction (DSE) is a system used to remove salts from brine water, utilizing organic solvents such as Diisopropylamine (DIPA); it is a well-studied system where the results obtained are promising because the removal of salts can be greater than 94%. The high demand of pure water for the oil and gas industry increases each year as access to fresh water is becoming complex and expensive. It is necessary to develop new technologies with higher recovery rates and environmentally friendly waste disposal. With a proposed semi-continuous system, divided into four stages, an analysis on retention times (RT), and a …

Targeting Macrophytes: Increased Water Quality Through Optimized Vegetation Considerations For Constructed Wetlands, Austin Mcbrady

Masters Theses (Archived)

This study of constructed wetland design investigated relationships between macrophyte species selection and planting density for water quality improvement. A lab-scale wetland was compared against a pilot-scale wetland in San Antonio, Texas at Mitchell Lake to measure differences in effluent water quality improvement using three native macrophyte species. Using a novel, two-phase method, a targeting macrophyte was identified from among other species based on its marked capability for improving water quality factors, then was planted in varied majority densities to compare differences in treatment effectiveness. The results of this study showed that this complimentary approach to wetland design displayed significant …

Validity And Reliability Of The Persian Version Of The Suboptimal Health Status Questionnaire Among University Staff In Iran, Erfan Ayubi, Salman Khazaei, Shiva Borzouei, Ali R. Soltanian, Samereh Ghelichkhani, Fatemeh Karbin, Yuxiang Yan, Manshu Song, Cuihong Tian, Wei Zhang, Jing Sun, Wei Wang

Research outputs 2022 to 2026

Background: Suboptimal Health Status Questionnaire-25 (SHSQ-25) is an established tool for measuring a precision health state between health and illness. The present study aims to assess the validity and reliability of a Persian version of SHSQ-25 (P-SHSQ-25) in a university staff Iranian population. Methods: A sample of 316 academic and supporting staff (163 males, age range from 23 to 64 years old) from Hamadan University of Medical Sciences, Hamadan, Iran was recruited in this population-based cross-sectional study with a questionnaire validation from Apri1 to October 2022. Forward-backward translation method was performed for the SHSQ-25 translation from English to Persian. Internal …

Using A Three-Dimensional Theoretical Orientation Matching Model To Predict Therapeutic Outcomes, Daniel Rhodes

Electronic Theses and Dissertations

Matching helpers and clients in a therapeutic setting is inefficient and ineffective. So far, there are no significant and enduring variables that reliably match helpers and clients that lead to positive therapeutic outcomes. This study attempts to match helper and client using theoretical orientation. It uses a quantitative methodology to predict therapeutic outcomes given match quality in the therapeutic dyad. Participants were 30 dyadic pairs—consisting of one helper and one client—who had a pre-existing therapeutic relationship. Each was given an assessment tool, used to measure their theoretical orientation to psychotherapy. Results showed no statistically significant relationships between theoretical orientation match …

Negative Psychology Of Anti-Semitism: Fear Of The Uncategorizable, Benjamin Strosberg

Electronic Theses and Dissertations

Anti-Semitism is a pervasive global issue, particularly prominent in the United States. Studying and defining anti-Semitism prove remarkably challenging for scholars, leading to inadequate understanding and exclusion from contemporary academic discourse and social justice initiatives. In this dissertation, I made the case that anti-Semitism is hard to categorize, stemming, in part, from the difficulty in categorizing what it is to be Jewish, which seems to be multi-form (a figure of thought, a race, an ethnicity, a religion, a nation, none of the above). In thinking about the difficulty in categorization, I constellated various instances of anti-Jewish practices across historical epochs …

Understanding Unacceptable Graduation Outcomes For Historically Excluded Trio Student Support Services Students, Erica Willis

Electronic Theses and Dissertations

The primary purpose of this mixed-methods study is to define the problem and to understand the system that has been leading to unacceptably low graduation outcomes for historically excluded Trio Student Support Services (Trio SSS) students at Mid-Atlantic University (MAU), a pseudonym. To achieve the primary purpose extant documents and institutional data that can shed light on system processes and institutional conditions that perpetuate disparities in graduation outcomes, particularly for historically excluded racial groups that exist at the intersection of first-generation status and/or low socioeconomic status, will be analyzed. The secondary purpose of this study is to identify potential change …

A Demonstration Of Enactivist Personality Assessment Using The Five-Factor Model, Garri Hovhannisyan

Electronic Theses and Dissertations

This dissertation seeks to extend the intellectual and existential horizon of the enactive approach by bringing forth an enactivist understanding of human cognitive life as it is lived from the perspective of personality traits. The theoretical task of this dissertation is to review existing evidence in support of the Enactivist Big-5 Theory (EB5T) of personality and its potential for bridging the phenomenological gap between minimal and human cognition. As a phenomenologically grounded theory of personality, EB5T conceptualizes individual differences not merely as differences in trait measures within a person but as differences in styles of how individuals bring forth, experience, …

Functional Cynicism, Michelle Fried

Electronic Theses and Dissertations

Trait cynicism, or “cynical hostility” as measured by the Minnesota Multiphasic Personality Inventory’s Cook-Medley Scale, is defined and studied as characteristics associated with psychopathology, interpersonal conflict, and negative health outcomes including heart disease and cognitive decline. Likewise, “organizational cynicism” is operationalized in industrial/organizational psychology for the purpose of describing and identifying an undesirable employee type in the workplace. This research proposes an alternative assessment. It reconnects cynicism with its roots in ancient philosophy by asking if cynical attitudes, despite their negative valence ascribed in the modern literature and conventional opinion, may serve a practical purpose. This study of Functional Cynicism …

Changing The Face Of Reading Instruction: Do Culturally Relevant Passages Increase The Effects Of The Repeated Reading Intervention For Middle School Black Girls With Reading Difficulties (Bgrds)?, Olajumoke Edith Oshokoya

Electronic Theses and Dissertations

Research has shown that fewer studies have focused on improving the reading abilities of middle school Black girls (Morris, 2007). As BGRDs progress through K – 12 grades, they increasingly rely on basic and advanced reading skills (i.e., oral reading fluency [ORF] and comprehension) to learn. Providing BGRDs with engaging reading passages that are relevant to their prior knowledge, background, interests, and experiences, is more likely to motivate them to read, and eventually improve their reading skills (Cartledge et al., 2015). While there is a growing body of literature focused on Black students’ experiences, currently no study has explored the …

Air-Jet Bioprinting Of Stem Cell-Encapsulated Alginate Micro-Droplets For Organoid Biomanufacturing, Mirabella B. Stump

Electronic Theses and Dissertations

Biomanufactured 3D-organoids show promise for modeling and treating various conditions, particularly insulin-dependent diabetes mellitus (type-1 diabetes). Pancreatic islet organoids serve as sustainable sources of insulin-producing β-cells, potentially restoring insulin regulation in patients and providing a long-term solution for diabetes. Hydrogel droplet printing is an emerging technique in regenerative medicine due to its advantageous tunability and biocompatibility; however, challenges of consistency, quality control, and scalability persist. To address these issues, we developed a novel air-jetting based droplet bioprinting system for the generation of monodispersed alginate micro-droplets. The objective of this project was to incorporate human induced pluripotent stem cells (hiPSCs) into …

Large - Scale Manufacturing Of Fluorescent Perfluorocarbon Nanoemulsions For Oxygen Delivery, Anneliese Troidle

Electronic Theses and Dissertations

Over 100,000 Americans are currently waiting for a life – saving organ transplant, yet 17 patients die daily waiting for a transplant they will never receive [1]. Preservation of organs is an area that has seen innovation throughout the years and can improve rates of transplantation, yet vascularized composite allotransplantation preservation has not followed suit [2]. Current standard of care is use of electrolyte solutions such as Histidine – Tryptophan – Ketoglutarate (HTK) or University of Wisconsin (UW) Solution, yet these perfusates lack an oxygen carrying component [3]. Hemoglobin – based oxygen carriers (HBOCs) …

The Contribution Of Principlism To Foster Ethical And Clinical Reciprocity In Resolving Healthcare Dilemmas, Dominic Glorioso

Electronic Theses and Dissertations

Principlism is an ethical method that uses an analytical framework based on a set of principles that can function as guidelines for healthcare professionals. The term was made

famous by the work of two bioethicists, Tom L. Beauchamp and James F. Childress. Their book, Principles of Biomedical Ethics and its multiple editions described a set of norms that are basic

for biomedical ethics. The first edition of their book was published in 1979, and the ninth edition in 2019. Its persistence and durability speak for themselves. In addition, their writings made

famous the four bioethical principles of respect for Autonomy, …

The Implications Of The Halogen Atom On The Physical Stability Of Amorphous Solid Dispersions, Mustafa Bookwala

Electronic Theses and Dissertations

Amorphous solid dispersions (ASD), although a promising formulation strategy for poorly water-soluble drugs, are susceptible to rapid, spontaneous recrystallization owing to their metastable nature. Non-covalent interactions (NCI) between the drug and polymer are known to help prevent ASD physical destabilization. Conventionally, hydrogen-bonding (H-bonding) is considered important for ASD formation and persistence. However, carbon-bound halogen atoms, which are frequently present on drug molecules and can form specific halogen-bonds (X-bond) with the polymer, remain relatively unexplored with respect to their ability to stabilize ASDs. It was, therefore, hypothesized that the presence of a peripheral Br on bromopropamide, and Cl on chlorpropamide will …

Development, Fabrication, And In Vitro Characterization Of Coconut Oil Lipidic Nanoparticles, Suneera Adlakha

Electronic Theses and Dissertations

Nano-delivery systems such as solid lipid nanoparticles (SLNs) are being actively explored. Drug encapsulation in SLNs helps in improving the drug’s bioavailability and can be used for targeted delivery. We hypothesize that the production of stable SLNs can be achieved using low melting point lipids such as coconut oil (CO). The safety of CO has been demonstrated, and its capacity to dissolve drug molecules has been established. Drug-free solid lipid nanoparticles (SLNs) were formulated through the utilization of sonication and magnetic stirring as production techniques. Different compositions and process variables that directly influence SLN manufacturing were evaluated with the target …

The Normative Requirement For Shared Decision Making (Sdm) In Healthcare Ethics, Margaret Nornor-Quadjie

Electronic Theses and Dissertations

Medicine and medical technology started to advance after World War II. During that period, the practice of medicine became technical. A lot began to happen in the biomedical world during the period after WWII that attracted comments, criticisms, and analyses from scholars. Perhaps, the 1947 Doctors’ Trial at the Nuremberg Tribunal and the Nuremberg Code may be said to be the defining moment for bioethics. These events eventually led to, in the United States, the passage of the National Research Act of 1974 that established the Institutional Review Board system and the National Commission for Protection of Human Subjects of …

Comparative Functional And Genomic Analysis Of Protein Targets Of Sexual Selection In Primates, Brianna Ports

Electronic Theses and Dissertations

Sexual selection is driven by the differential reproductive success of individuals, which is influenced by competition for mates and mate choice. In primates, this selective pressure has been attributed to the development of distinct anatomical, physiological, and behavioral characteristics. By employing comparative functional and genomic methodologies, this study aimed to assess the repercussions of primate sexual selection. To better understand the mechanisms driving sexually selected traits, an unbiased genome-wide analysis was used to associate rates of protein evolution with relative testes size and sexual size dimorphism. While previous research focused on the rapid evolution of male reproductive proteins in response …

Role Of The Anti-Viral Immune Response In Neural Cell Modulation And Neurological Sequelae Of Childhood Viral Infections, Yashika Kamte

Electronic Theses and Dissertations

Viral infections of the central nervous system (CNS) often result in neurological sequelae and are considered a risk factor for the development of neurological disease. Moreover, the outcomes of a viral infection are largely dependent on the age of the host, with younger hosts developing more profound neuropathology. Perhaps the developing brain coupled with an immature immune system contributes to worse outcomes in the very young. Children suffering from brain infections are more prone to develop enduring neurological impairments even after recovery from the infection. Although majority of the brain growth occurs in utero, neurodevelopment continues throughout the juvenile …

The Effect Of Culture And Society On Postpartum Depression: Impacts Observed In India And America, Roma Agarwal

The Crown: Syracuse Honors Research Journal

No abstract provided.

E Hui Me Ke Kaiāulu: To Connect With The Community, Heather Kayleen Bartlett

Dissertations and Theses

Urban planning literature contains a wealth of knowledge on community engagement as a crucial component of the planning process, yet there remains a notable gap in our understanding of best practices when it comes to sustaining community involvement for ongoing plan implementation. The County of Hawai'i, has charted a unique course through the establishment of Action Committees which serve as an intermediary to uplift grassroots implementation efforts while remaining closely entwined with County resources and processes. This interplay provides a unique case study that results in somewhat of an "identity crisis": Action Committees do not have the autonomy of external …

Staff Council Minutes, Georgia Southern University

Staff Council Meeting Minutes & Agendas

No abstract provided.

Staff Council Agenda, Georgia Southern University

Staff Council Meeting Minutes & Agendas

No abstract provided.

Diversity In Post-Brexit Britain: Looking At Its Current State And Future Trends, Camilla Witmer

The Crown: Syracuse Honors Research Journal

No abstract provided.

Framing Of Immigration: The Discussion Of Immigration And Its Influence On The American Identity, Nathan Torabi

The Crown: Syracuse Honors Research Journal

No abstract provided.